id category name description provided_by synonym 0000233 0000589 0100001 comment consider created_by creation_date default_namespace deprecated has_alternative_id has_db_xref has_o_b_o_format_version has_o_b_o_namespace is_class_level is_metadata_tag knowledge_source license logical_interpretation object predicate relation shorthand subject type version GO:0009590 biolink:NamedThing detection of gravity The series of events in which a gravitational stimulus is received and converted into a molecular signal. got7fsn_ti perception of gravity biological_process owl:Class GO:0009582 biolink:NamedThing detection of abiotic stimulus The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of abiotic stimulus biological_process owl:Class GO:0048282 biolink:NamedThing determinate inflorescence morphogenesis The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can only produce a predetermined number of floral meristems. got7fsn_ti biological_process owl:Class GO:0048281 biolink:NamedThing inflorescence morphogenesis The process in which the anatomical structures of inflorescences are generated and organized. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers. got7fsn_ti biological_process owl:Class GO:0007319 biolink:NamedThing negative regulation of oskar mRNA translation Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein. got7fsn_ti down-regulation of oskar mRNA translation|downregulation of oskar mRNA translation|down regulation of oskar mRNA translation|inhibition of oskar mRNA translation biological_process owl:Class GO:0046011 biolink:NamedThing regulation of oskar mRNA translation Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex. got7fsn_ti biological_process owl:Class GO:0043909 biolink:NamedThing N-acetylcitrulline deacetylase activity Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate. got7fsn_ti acetylcitrulline deacetylase activity|N-acetyl-L-citrulline deacetylase activity RHEA:61092 molecular_function owl:Class GO:0016811 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. got7fsn_ti Reactome:R-HSA-9673054|Reactome:R-HSA-9673053|EC:3.5.1.- molecular_function owl:Class GO:0048523 biolink:NamedThing negative regulation of cellular process Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. got7fsn_ti inhibition of cellular process|down regulation of cellular process|negative regulation of cellular physiological process|down-regulation of cellular process|downregulation of cellular process GO:0051243 biological_process owl:Class GO:0050794 biolink:NamedThing regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. got7fsn_ti regulation of cellular physiological process GO:0051244 biological_process owl:Class GO:0018647 biolink:NamedThing phenanthrene 1,2-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide. got7fsn_ti UM-BBD_enzymeID:e0333|EC:1.14.13.- molecular_function owl:Class GO:0016709 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. got7fsn_ti oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen Reactome:R-HSA-2162187|Reactome:R-HSA-2162194|EC:1.14.13.- molecular_function owl:Class GO:0071241 biolink:NamedThing cellular response to inorganic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. got7fsn_ti mah 2009-12-03T02:35:49Z biological_process owl:Class GO:0010035 biolink:NamedThing response to inorganic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. got7fsn_ti biological_process owl:Class GO:0005723 biolink:NamedThing alpha-heterochromatin A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization. got7fsn_ti cellular_component owl:Class GO:0005721 biolink:NamedThing pericentric heterochromatin Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. got7fsn_ti nuclear cluster|centromeric heterochromatin|nuclear centric heterochromatin|nuclear pericentric heterochromatin|centric heterochromatin GO:0031618|GO:0002137 cellular_component owl:Class GO:0046527 biolink:NamedThing glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. got7fsn_ti molecular_function owl:Class GO:0016758 biolink:NamedThing hexosyltransferase activity Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring hexosyl groups EC:2.4.1.- molecular_function owl:Class GO:0019046 biolink:NamedThing release from viral latency The process by which a virus begins to replicate following a latency replication decision (switch). got7fsn_ti GO:0075717 biological_process owl:Class GO:0016032 biolink:NamedThing viral process A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. got7fsn_ti viral infection|virulence|virus process See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'. GO:0022415 Wikipedia:Viral_life_cycle biological_process owl:Class GO:0043545 biolink:NamedThing molybdopterin cofactor metabolic process The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. got7fsn_ti Moco metabolic process|Moco metabolism|molybdopterin cofactor metabolism biological_process owl:Class GO:0051189 biolink:NamedThing prosthetic group metabolic process The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. got7fsn_ti prosthetic group metabolism|coenzyme and prosthetic group metabolic process|coenzyme and prosthetic group metabolism biological_process owl:Class GO:0047187 biolink:NamedThing deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate. got7fsn_ti deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity|S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity|deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity|S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity EC:2.3.1.49|MetaCyc:2.3.1.49-RXN|RHEA:20393 molecular_function owl:Class GO:0140096 biolink:NamedThing catalytic activity, acting on a protein Catalytic activity that acts to modify a protein. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-14T10:32:59Z molecular_function owl:Class GO:0021915 biolink:NamedThing neural tube development The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. got7fsn_ti biological_process owl:Class GO:0032502 biolink:NamedThing developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. got7fsn_ti development|single-organism developmental process jl 2012-12-19T12:21:31Z GO:0044767 biological_process owl:Class GO:0031853 biolink:NamedThing nociceptin receptor binding Binding to a nociceptin receptor. got7fsn_ti nociceptin receptor ligand molecular_function owl:Class GO:0031628 biolink:NamedThing opioid receptor binding Binding to an opioid receptor. got7fsn_ti molecular_function owl:Class GO:0042550 biolink:NamedThing photosystem I stabilization The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. got7fsn_ti biological_process owl:Class GO:0042548 biolink:NamedThing regulation of photosynthesis, light reaction Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis. got7fsn_ti biological_process owl:Class GO:0072294 biolink:NamedThing specification of metanephric connecting tubule identity The process in which the connecting tubule of the metanephric nephron acquires its identity. got7fsn_ti mah 2010-04-09T04:00:31Z biological_process owl:Class GO:0072293 biolink:NamedThing specification of metanephric nephron tubule identity The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity. got7fsn_ti mah 2010-04-09T03:58:10Z biological_process owl:Class GO:0048511 biolink:NamedThing rhythmic process Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. got7fsn_ti rhythm biological_process owl:Class GO:0008150 biolink:NamedThing biological_process A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. got7fsn_ti physiological process|biological process|single organism process|single-organism process Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. jl 2012-09-19T15:05:24Z GO:0000004|GO:0044699|GO:0007582 Wikipedia:Biological_process biological_process owl:Class GO:0062203 biolink:NamedThing Viteagnusin D synthase activity Catalysis of the reaction: H2O + peregrinol diphosphate = diphosphate + viteagnusin D. got7fsn_ti dph 2020-01-02T18:25:47Z RHEA:62180 molecular_function owl:Class GO:0016838 biolink:NamedThing carbon-oxygen lyase activity, acting on phosphates Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. got7fsn_ti EC:4.2.3.- molecular_function owl:Class GO:0120152 biolink:NamedThing calcium-dependent outer dynein arm binding Binding to an outer dynein arm in the presence of calcium. got7fsn_ti krc 2018-04-27T16:33:39Z molecular_function owl:Class GO:0048306 biolink:NamedThing calcium-dependent protein binding Binding to a protein or protein complex in the presence of calcium. got7fsn_ti molecular_function owl:Class GO:0098039 biolink:NamedThing replicative transposition, DNA-mediated Process of transposition in which the existing element is replicated and one of the copies is excised and integrated at a new target site. Also referred to as copy-and-paste transposition. got7fsn_ti copy-and-paste transposition|transpositional DNA genome replication bm 2012-07-20T16:52:02Z biological_process owl:Class GO:0006313 biolink:NamedThing transposition, DNA-mediated Any process involved in a type of transpositional recombination which occurs via a DNA intermediate. got7fsn_ti Class II transposition|Tc1/mariner transposition|Tc3 transposition|P-element transposition|P-element excision|DNA transposition GO:0006317|GO:0006318 biological_process owl:Class GO:0048920 biolink:NamedThing posterior lateral line neuromast primordium migration The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop. got7fsn_ti PLL neuromast primordium migration biological_process owl:Class GO:0048883 biolink:NamedThing neuromast primordium migration The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop. got7fsn_ti lateral line primordium migration biological_process owl:Class GO:0034070 biolink:NamedThing aminoglycoside 1-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring. got7fsn_ti molecular_function owl:Class GO:0034069 biolink:NamedThing aminoglycoside N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside. got7fsn_ti kanamycin acetyltransferase activity molecular_function owl:Class GO:0061663 biolink:NamedThing NEDD8 ligase activity Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T13:57:00Z molecular_function owl:Class GO:0019788 biolink:NamedThing NEDD8 transferase activity Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. got7fsn_ti RUB1 conjugating enzyme activity|NEDD8 conjugating enzyme activity|Hub1 conjugating enzyme activity GO:0019945|GO:0042295|GO:0016976 Reactome:R-HSA-8956025|Reactome:R-HSA-8952618|Reactome:R-HSA-8951764|Reactome:R-HSA-8952638|Reactome:R-HSA-8951661|Reactome:R-HSA-8951648|Reactome:R-HSA-8952044 molecular_function owl:Class GO:0106054 biolink:NamedThing tRNA U34 thiol-transferase activity Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+. got7fsn_ti tRNA-specific 2-thiouridylase|tRNA U34 2-thiouridylase hjd 2017-09-05T19:10:12Z molecular_function owl:Class GO:0016783 biolink:NamedThing sulfurtransferase activity Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). got7fsn_ti sulphurtransferase activity|tRNA sulfurtransferase activity Reactome:R-HSA-6782264|EC:2.8.1.-|Reactome:R-HSA-1614618|Reactome:R-HSA-947538 molecular_function owl:Class GO:0021852 biolink:NamedThing pyramidal neuron migration to cerebral cortex The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex. got7fsn_ti projection neuron migration|pyramidal neuron migration https://github.com/geneontology/go-ontology/issues/21476 biological_process owl:Class GO:0001764 biolink:NamedThing neuron migration The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. got7fsn_ti neuron guidance|neuron chemotaxis|neuronal migration Wikipedia:Neuron_migration|Wikipedia:Neural_development#Neuron_migration biological_process owl:Class GO:0044651 biolink:NamedThing adhesion of symbiont to host epithelial cell The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly. got7fsn_ti jl 2012-07-12T12:47:09Z biological_process owl:Class GO:0044650 biolink:NamedThing adhesion of symbiont to host cell The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly. got7fsn_ti jl 2012-07-12T12:42:14Z biological_process owl:Class GO:0003026 biolink:NamedThing regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control. got7fsn_ti aortic arch baroreceptor control of systemic arterial blood pressure biological_process owl:Class GO:0001976 biolink:NamedThing nervous system process involved in regulation of systemic arterial blood pressure The regulation of blood pressure mediated by detection of stimuli and a neurological response. got7fsn_ti blood pressure regulation by neurological process|neurological process involved in regulation of systemic arterial blood pressure|neurological system process involved in regulation of systemic arterial blood pressure|fast control of arterial pressure biological_process owl:Class GO:0051504 biolink:NamedThing diterpene phytoalexin precursor biosynthetic process pathway A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins. got7fsn_ti diterpene phytoalexin precursor synthesis pathway|diterpene phytoalexin precursor formation pathway|diterpene phytoalexin precursor anabolism pathway MetaCyc:PWY-2981 biological_process owl:Class GO:0046246 biolink:NamedThing terpene biosynthetic process The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units. got7fsn_ti terpene biosynthesis|terpene synthesis|terpene formation|terpene anabolism biological_process owl:Class GO:0018748 biolink:NamedThing iprodione amidohydrolase activity Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate. got7fsn_ti UM-BBD_reactionID:r0706 molecular_function owl:Class GO:0098681 biolink:NamedThing synaptic ribbon A non-membrane bound, electron dense structure associated that extends perpendicular to the presynaptic membrane in ribbon synapses. The ribbon's surface is studded with small particles to which synaptic vesicles tether via fine filaments. The tethered vesicles function as a pool, several fold greater than the docked pool available for fast release, which supports sustained release of vesicles. Synaptic ribbons may be plate like or spherical. got7fsn_ti dos 2017-02-05T15:59:43Z cellular_component owl:Class GO:0043232 biolink:NamedThing intracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. got7fsn_ti intracellular non-membrane-enclosed organelle cellular_component owl:Class GO:0005585 biolink:NamedThing collagen type II trimer A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. got7fsn_ti Wikipedia:Collagen_type_II cellular_component owl:Class GO:0005583 biolink:NamedThing fibrillar collagen trimer Any triple helical collagen trimer that forms fibrils. got7fsn_ti cellular_component owl:Class GO:0150017 biolink:NamedThing basal proximal dendrite Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is the closest to the cell body of the neuron (the soma). got7fsn_ti bc 2017-12-21T12:17:00Z cellular_component owl:Class GO:0097441 biolink:NamedThing basal dendrite A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon. got7fsn_ti basilar dendrite pr 2012-12-06T13:46:28Z NIF_Subcellular:sao1079900774 cellular_component owl:Class GO:0010461 biolink:NamedThing light-activated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a light stimulus. got7fsn_ti molecular_function owl:Class GO:0005216 biolink:NamedThing ion channel activity Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). got7fsn_ti molecular_function owl:Class GO:0034319 biolink:NamedThing alcohol O-butanoyltransferase activity Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester. got7fsn_ti molecular_function owl:Class GO:0034318 biolink:NamedThing alcohol O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule. got7fsn_ti acyl-CoA:alcohol O-acyltransferase activity|acyl-CoA:ethanol O-acyltransferase|acyl-coenzymeA:alcohol O-acyltransferase activity|AEATase activity|alcohol acyltransferase activity|acyl-coenzymeA:ethanol O-acyltransferase activity molecular_function owl:Class GO:0007310 biolink:NamedThing oocyte dorsal/ventral axis specification The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte dorsal/ventral axis determination|oocyte dorsal-ventral axis specification|oocyte dorsoventral axis specification GO:0008072|GO:0048123 biological_process owl:Class GO:0007309 biolink:NamedThing oocyte axis specification The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte axis determination GO:0048111 biological_process owl:Class GO:0050267 biolink:NamedThing rubber cis-polyprenylcistransferase activity Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit. got7fsn_ti rubber transferase activity|rubber allyltransferase activity|poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity|cis-prenyl transferase activity|isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity|rubber polymerase activity|rubber prenyltransferase activity RHEA:18801|EC:2.5.1.20|MetaCyc:2.5.1.20-RXN molecular_function owl:Class GO:0002094 biolink:NamedThing polyprenyltransferase activity Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). got7fsn_ti molecular_function owl:Class GO:0035894 biolink:NamedThing positive regulation of platelet aggregation in other organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism. got7fsn_ti upregulation of platelet aggregation in other organism|up-regulation of platelet aggregation in other organism bf 2011-06-15T02:28:46Z biological_process owl:Class GO:0035892 biolink:NamedThing modulation of platelet aggregation in other organism Any process in which an organism modulates the frequency, rate or extent of platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. got7fsn_ti regulation of platelet aggregation in other organism|modulation by organism of platelet aggregation in other organism bf 2011-06-15T02:21:10Z biological_process owl:Class GO:0072010 biolink:NamedThing glomerular epithelium development The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. got7fsn_ti mah 2010-01-25T02:02:14Z biological_process owl:Class GO:0072073 biolink:NamedThing kidney epithelium development The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. got7fsn_ti mah 2010-01-25T04:37:42Z biological_process owl:Class GO:0051524 biolink:NamedThing cell growth mode switching, bipolar to monopolar The process in which a cell switches from bipolar cell growth to monopolar cell growth. got7fsn_ti biological_process owl:Class GO:0061162 biolink:NamedThing establishment of monopolar cell polarity The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. got7fsn_ti dph 2010-06-23T09:30:59Z biological_process owl:Class GO:0018627 biolink:NamedThing 2-aminobenzenesulfonate 2,3-dioxygenase activity Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol. got7fsn_ti 2-aminobenzenesulfonate dioxygenase activity|2-aminosulfobenzene 2,3-dioxygenase activity|2-aminobenzenesulphonate 2,3-dioxygenase activity|2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)|2-aminobenzenesulphonate dioxygenase activity GO:0018605 KEGG_REACTION:R05156|EC:1.14.12.14|MetaCyc:2ASDOSALCAL-RXN|UM-BBD_reactionID:r0218|RHEA:23468 molecular_function owl:Class GO:0016708 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor. got7fsn_ti oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor EC:1.14.12.- molecular_function owl:Class GO:0120101 biolink:NamedThing bacterial-type flagellum stator complex A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. got7fsn_ti bacterial-type flagellum torque generator complex|bacterial-type flagellum motor force generator complex krc 2017-10-03T16:06:16Z cellular_component owl:Class GO:0005887 biolink:NamedThing integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to plasma membrane cellular_component owl:Class GO:0019156 biolink:NamedThing isoamylase activity Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins. got7fsn_ti debranching enzyme activity|glycogen alpha-1,6-glucanohydrolase activity MetaCyc:RXN-12280|MetaCyc:3.2.1.68-RXN|EC:3.2.1.68|MetaCyc:RXN-14380 molecular_function owl:Class GO:0004553 biolink:NamedThing hydrolase activity, hydrolyzing O-glycosyl compounds Catalysis of the hydrolysis of any O-glycosyl bond. got7fsn_ti O-glucosyl hydrolase activity GO:0016800 Reactome:R-HSA-9661820|EC:3.2.1.-|Reactome:R-HSA-6786652|Reactome:R-HSA-5694563 molecular_function owl:Class GO:0110148 biolink:NamedThing biomineralization The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products. got7fsn_ti mineralization|biomineralisation|mineralisation|biomineral formation kmv 2019-06-10T17:55:28Z Wikipedia:Biomineralization biological_process owl:Class GO:0050386 biolink:NamedThing ureidosuccinase activity Catalysis of the reaction: N-carbamoyl-L-aspartate + H(2)O + 2 H(+) = L-aspartate + CO(2) + NH(4)(+). got7fsn_ti N-carbamoyl-L-aspartate amidohydrolase activity MetaCyc:UREIDOSUCCINASE-RXN|EC:3.5.1.7|KEGG_REACTION:R00484|RHEA:14365 molecular_function owl:Class GO:0018160 biolink:NamedThing peptidyl-pyrromethane cofactor linkage The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine. got7fsn_ti dipyrromethane cofactor binding|peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine GO:0033035|GO:0018354 RESID:AA0252 biological_process owl:Class GO:0018198 biolink:NamedThing peptidyl-cysteine modification The modification of peptidyl-cysteine. got7fsn_ti biological_process owl:Class GO:0090216 biolink:NamedThing positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity Any process that increases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. got7fsn_ti tb 2010-01-12T10:00:45Z biological_process owl:Class GO:0090218 biolink:NamedThing positive regulation of lipid kinase activity Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. got7fsn_ti tb 2010-01-12T10:18:30Z biological_process owl:Class GO:0048658 biolink:NamedThing anther wall tapetum development The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure. got7fsn_ti tapetum development|tapetal layer development biological_process owl:Class GO:0048856 biolink:NamedThing anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. got7fsn_ti development of an anatomical structure biological_process owl:Class GO:0042391 biolink:NamedThing regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti biological_process owl:Class GO:0065008 biolink:NamedThing regulation of biological quality Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. got7fsn_ti regulation of biological attribute|regulation of biological characteristic biological_process owl:Class GO:1990216 biolink:NamedThing positive regulation by symbiont of host transcription Any process in which an organism activates, maintains or increases the frequency, rate or extent of transcription in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-10T15:45:17Z biological_process owl:Class GO:0052026 biolink:NamedThing modulation by symbiont of host transcription Any process in which an organism modulates the frequency, rate or extent of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class GO:0022021 biolink:NamedThing caudal ganglionic eminence cell proliferation The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class GO:0022012 biolink:NamedThing subpallium cell proliferation in forebrain The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class GO:0021676 biolink:NamedThing rhombomere 8 structural organization The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti rhombomere 8 structural organisation biological_process owl:Class GO:0021595 biolink:NamedThing rhombomere structural organization The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. got7fsn_ti rhombomere structural organisation biological_process owl:Class GO:0042717 biolink:NamedThing plasma membrane-derived chromatophore membrane The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles. got7fsn_ti cellular_component owl:Class GO:0034357 biolink:NamedThing photosynthetic membrane A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place. got7fsn_ti cellular_component owl:Class GO:0036177 biolink:NamedThing filamentous growth of a population of unicellular organisms in response to pH The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti bf 2012-03-29T01:43:04Z biological_process owl:Class GO:0009268 biolink:NamedThing response to pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti biological_process owl:Class GO:0010623 biolink:NamedThing programmed cell death involved in cell development The activation of endogenous cellular processes that result in the death of a cell as part of its development. got7fsn_ti programmed cell death involved in development|developmental programmed cell death This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. biological_process owl:Class GO:0048869 biolink:NamedThing cellular developmental process A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. got7fsn_ti biological_process owl:Class GO:0110036 biolink:NamedThing C2 domain binding Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes. got7fsn_ti kmv 2017-07-20T20:45:56Z molecular_function owl:Class GO:0019904 biolink:NamedThing protein domain specific binding Binding to a specific domain of a protein. got7fsn_ti protein domain-specific binding molecular_function owl:Class GO:0047578 biolink:NamedThing 4-hydroxyglutamate transaminase activity Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate. got7fsn_ti 4-hydroxyglutamate aminotransferase activity|4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN|RHEA:10480|EC:2.6.1.23|Reactome:R-HSA-6784393 molecular_function owl:Class GO:0008483 biolink:NamedThing transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. got7fsn_ti aminotransferase activity Reactome:R-HSA-1237102|EC:2.6.1.- molecular_function owl:Class GO:0047906 biolink:NamedThing fucosterol-epoxide lyase activity Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol. got7fsn_ti (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity|(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming) KEGG_REACTION:R03723|EC:4.1.2.33|MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN|RHEA:10884 molecular_function owl:Class GO:0016832 biolink:NamedThing aldehyde-lyase activity Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. got7fsn_ti aldolase activity GO:0016228 EC:4.1.2.- molecular_function owl:Class GO:0036496 biolink:NamedThing regulation of translational initiation by eIF2 alpha dephosphorylation Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha. got7fsn_ti bf 2015-02-05T10:21:31Z biological_process owl:Class GO:0008152 biolink:NamedThing metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. got7fsn_ti metabolism|metabolic process resulting in cell growth|single-organism metabolic process|multicellular organism metabolic process|metabolism resulting in cell growth Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. jl 2012-10-17T15:46:40Z GO:0044236|GO:0044710 Wikipedia:Metabolism biological_process owl:Class GO:0019081 biolink:NamedThing viral translation A process by which viral mRNA is translated into viral protein, using the host cellular machinery. got7fsn_ti viral protein formation|viral protein synthesis|viral protein biosynthesis|viral protein anabolism|viral protein biosynthetic process biological_process owl:Class GO:0035041 biolink:NamedThing sperm chromatin decondensation Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus. got7fsn_ti biological_process owl:Class GO:0006325 biolink:NamedThing chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. got7fsn_ti chromatin organisation|chromatin modification|establishment or maintenance of chromatin architecture GO:0016568 biological_process owl:Class GO:0002299 biolink:NamedThing alpha-beta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti alpha-beta intraepithelial T-lymphocyte differentiation|alpha-beta intraepithelial T cell development|alpha-beta intraepithelial T-cell differentiation|alpha-beta intraepithelial T lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:0046632 biolink:NamedThing alpha-beta T cell differentiation The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. got7fsn_ti alpha-beta T-cell differentiation|alpha-beta T cell development|alpha-beta T lymphocyte differentiation|alpha-beta T-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:1900049 biolink:NamedThing regulation of histone exchange Any process that modulates the frequency, rate or extent of histone exchange. got7fsn_ti regulation of histone displacement|regulation of histone chaperone|regulation of histone replacement se 2012-01-19T10:59:02Z biological_process owl:Class GO:1902275 biolink:NamedThing regulation of chromatin organization Any process that modulates the frequency, rate or extent of chromatin organization. got7fsn_ti regulation of chromatin modification|regulation of establishment or maintenance of chromatin architecture|regulation of chromatin organisation bf 2013-07-01T13:21:52Z GO:1903308 biological_process owl:Class GO:0060087 biolink:NamedThing relaxation of vascular associated smooth muscle A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity. got7fsn_ti vascular smooth muscle relaxation|relaxation of vascular smooth muscle|positive regulation of relaxation of vascular smooth muscle|regulation of relaxation of vascular smooth muscle|negative regulation of relaxation of vascular smooth muscle GO:1905657|GO:1905658|GO:1905659 biological_process owl:Class GO:0044557 biolink:NamedThing relaxation of smooth muscle A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. got7fsn_ti smooth muscle relaxation jl 2012-04-05T02:42:28Z biological_process owl:Class GO:0043571 biolink:NamedThing maintenance of CRISPR repeat elements Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences. got7fsn_ti maintenance of clustered regularly interspaced short palindromic repeat elements|CRISPR element metabolic process|CRISPR element metabolism biological_process owl:Class GO:0043570 biolink:NamedThing maintenance of DNA repeat elements Any process involved in sustaining the fidelity and copy number of DNA repeat elements. got7fsn_ti biological_process owl:Class GO:0050985 biolink:NamedThing peptidyl-threonine sulfation The sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine. got7fsn_ti RESID:AA0362 biological_process owl:Class GO:0006477 biolink:NamedThing protein sulfation The addition of a sulfate group as an ester to a protein amino acid. got7fsn_ti protein amino acid sulfation|protein amino acid sulphation biological_process owl:Class GO:1900602 biolink:NamedThing endocrocin biosynthetic process The chemical reactions and pathways resulting in the formation of endocrocin. got7fsn_ti endocrocin biosynthesis|endocrocin formation|endocrocin synthesis|endocrocin anabolism di 2012-05-15T06:57:42Z biological_process owl:Class GO:0044550 biolink:NamedThing secondary metabolite biosynthetic process The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. got7fsn_ti secondary metabolite biosynthesis jl 2012-03-29T01:55:18Z biological_process owl:Class GO:0034857 biolink:NamedThing 2-(methylthio)benzothiazole monooxygenase activity Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole. got7fsn_ti UM-BBD_reactionID:r1287 molecular_function owl:Class GO:0016705 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. got7fsn_ti oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous EC:1.14.-.- molecular_function owl:Class GO:0070420 biolink:NamedThing Ku-DNA ligase complex A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria. got7fsn_ti cellular_component owl:Class GO:0070419 biolink:NamedThing nonhomologous end joining complex A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends. got7fsn_ti non-homologous end joining complex|NHEJ complex cellular_component owl:Class GO:0052805 biolink:NamedThing imidazole-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. got7fsn_ti imidazole catabolism|imidazole degradation|imidazole breakdown biological_process owl:Class GO:0044270 biolink:NamedThing cellular nitrogen compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. got7fsn_ti nitrogen compound catabolism|nitrogen compound breakdown|nitrogen compound degradation biological_process owl:Class GO:0031035 biolink:NamedThing myosin filament disassembly The disassembly of a filament composed of myosin molecules. got7fsn_ti myosin depolymerization biological_process owl:Class GO:0031033 biolink:NamedThing myosin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules. got7fsn_ti myosin polymerization or depolymerization|myosin filament assembly or disassembly|myosin filament organisation Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton. biological_process owl:Class GO:0011000 biolink:NamedThing replication fork arrest at mating type locus A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus. got7fsn_ti tb 2009-06-24T12:02:48Z biological_process owl:Class GO:0043111 biolink:NamedThing replication fork arrest Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected. got7fsn_ti replication fork stalling|negative regulation of DNA replication at replication fork barrier|replication fork blocking See also the biological process term 'site-specific replication termination ; GO:0071170' and its children. biological_process owl:Class GO:0019365 biolink:NamedThing pyridine nucleotide salvage Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis. got7fsn_ti pyridine nucleotide cycling biological_process owl:Class GO:0043173 biolink:NamedThing nucleotide salvage Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. got7fsn_ti Wikipedia:Nucleotide_salvage biological_process owl:Class GO:0099646 biolink:NamedThing neurotransmitter receptor transport, plasma membrane to endosome Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome. got7fsn_ti biological_process owl:Class GO:0048227 biolink:NamedThing plasma membrane to endosome transport Transport of a vesicle from the plasma membrane to the endosome. got7fsn_ti biological_process owl:Class GO:1990736 biolink:NamedThing regulation of vascular associated smooth muscle cell membrane depolarization Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell. got7fsn_ti regulation of vascular smooth muscle cell membrane depolarization sl 2015-04-29T22:33:19Z biological_process owl:Class GO:0051899 biolink:NamedThing membrane depolarization The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti biological_process owl:Class GO:0018452 biolink:NamedThing 5-exo-hydroxycamphor dehydrogenase activity Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane. got7fsn_ti RHEA:32879|EC:1.1.1.327|MetaCyc:R542-RXN|UM-BBD_reactionID:r0427 molecular_function owl:Class GO:0016616 biolink:NamedThing oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. got7fsn_ti glycolate reductase|NADH-dependent glyoxylate reductase|glyoxylic acid reductase Reactome:R-HSA-975629|EC:1.1.1.- molecular_function owl:Class GO:0009947 biolink:NamedThing centrolateral axis specification The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf. got7fsn_ti mediolateral axis specification|centrolateral axis determination biological_process owl:Class GO:0009798 biolink:NamedThing axis specification The establishment, maintenance and elaboration of a pattern along a line or around a point. got7fsn_ti axis determination biological_process owl:Class GO:0018555 biolink:NamedThing phenanthrene dioxygenase activity Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0455 molecular_function owl:Class GO:0016702 biolink:NamedThing oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. got7fsn_ti Reactome:R-HSA-5164399|Reactome:R-HSA-9018880|Reactome:R-HSA-9020274|Reactome:R-HSA-9026408|EC:1.13.11.-|Reactome:R-HSA-2161907|Reactome:R-HSA-2161775|Reactome:R-HSA-2161917|Reactome:R-HSA-9026918 molecular_function owl:Class GO:0005172 biolink:NamedThing vascular endothelial growth factor receptor binding Binding to a vascular endothelial growth factor receptor. got7fsn_ti VEGF receptor binding|vascular endothelial growth factor|vascular endothelial growth factor receptor ligand|VEGFR binding molecular_function owl:Class GO:0070851 biolink:NamedThing growth factor receptor binding Binding to a growth factor receptor. got7fsn_ti mah 2009-08-07T11:23:02Z molecular_function owl:Class GO:0140113 biolink:NamedThing extracellular microvesicle biogenesis The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding. got7fsn_ti extracellular microvesicle assembly https://github.com/geneontology/go-ontology/issues/14256 pg 2017-10-23T12:00:11Z biological_process owl:Class GO:0140112 biolink:NamedThing extracellular vesicle biogenesis The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. got7fsn_ti extracellular vesicle assembly https://github.com/geneontology/go-ontology/issues/14256 pg 2017-10-23T11:53:42Z biological_process owl:Class GO:0031250 biolink:NamedThing anaerobic ribonucleoside-triphosphate reductase complex An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit. got7fsn_ti cellular_component owl:Class GO:0032991 biolink:NamedThing protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. got7fsn_ti protein-protein complex|macromolecular complex|protein complex|protein containing complex|macromolecule complex A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. GO:0043234 cellular_component owl:Class GO:0046294 biolink:NamedThing formaldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. got7fsn_ti formaldehyde degradation|formaldehyde breakdown|methanal catabolic process|formaldehyde catabolism|methanal catabolism biological_process owl:Class GO:0044282 biolink:NamedThing small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. got7fsn_ti small molecule catabolism Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. jl 2010-01-26T12:06:10Z biological_process owl:Class GO:0071133 biolink:NamedThing alpha9-beta1 integrin-ADAM8 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8. got7fsn_ti ITGA9-ITGB1-ADAM8 complex mah 2009-11-13T02:28:49Z cellular_component owl:Class GO:0007636 biolink:NamedThing chemosensory jump behavior The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance. got7fsn_ti jump response to chemical stimulus|chemosensory jump behaviour biological_process owl:Class GO:0007635 biolink:NamedThing chemosensory behavior Behavior that is dependent upon the sensation of chemicals. got7fsn_ti chemosensory behaviour|behavioural response to chemical stimulus|behavioral response to chemical stimulus biological_process owl:Class GO:0060592 biolink:NamedThing mammary gland formation The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme. got7fsn_ti mammary line formation|mammary placode formation|mammary sprout formation|mammary bud formation dph 2009-05-13T08:47:52Z biological_process owl:Class GO:0035740 biolink:NamedThing CD8-positive, alpha-beta T cell proliferation The expansion of a CD8-positive, alpha-beta T cell population by cell division. got7fsn_ti bf 2011-03-17T02:13:54Z biological_process owl:Class GO:0036037 biolink:NamedThing CD8-positive, alpha-beta T cell activation The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti bf 2011-11-03T10:34:12Z biological_process owl:Class GO:0097674 biolink:NamedThing SCF-YLR352W ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is YLR352W in S. cerevisiae. got7fsn_ti pr 2014-10-06T10:30:54Z cellular_component owl:Class GO:0019005 biolink:NamedThing SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). got7fsn_ti CDL1 complex|cullin-RING ligase 1|SCF complex|CRL1 complex|SCF complex substrate recognition subunit|Cul1-RING ubiquitin ligase complex|Skp1/Cul1/F-box protein complex Wikipedia:SCF_complex cellular_component owl:Class GO:0030532 biolink:NamedThing small nuclear ribonucleoprotein complex A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs. got7fsn_ti small nuclear ribonucleoprotein|snRNP Wikipedia:SnRNP cellular_component owl:Class GO:0140513 biolink:NamedThing nuclear protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. got7fsn_ti nuclear complex pg 2020-09-09T05:12:38Z cellular_component owl:Class GO:0034039 biolink:NamedThing 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. got7fsn_ti 8-oxoG DNA N-glycosylase activity molecular_function owl:Class GO:0008534 biolink:NamedThing oxidized purine nucleobase lesion DNA N-glycosylase activity Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. got7fsn_ti DNA glycosylase/AP-lyase activity|DNA glycosylase/beta-lyase activity|oxidized purine base lesion DNA N-glycosylase activity|8-oxoguanine DNA glycosylase activity|2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity|formamidopyrimidine-DNA glycosylase activity|Fapy-DNA glycosylase activity|2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity|DNA-formamidopyrimidine glycosylase activity|purine-specific oxidized base lesion DNA N-glycosylase activity|bifunctional DNA glycosylase activity|Fpg protein|deoxyribonucleate glycosidase activity|DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing] Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. GO:0003907 Reactome:R-HSA-110244|MetaCyc:3.2.2.23-RXN|Reactome:R-HSA-110229|Reactome:R-HSA-110243|EC:3.2.2.23 molecular_function owl:Class GO:0044186 biolink:NamedThing host cell lipid droplet Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins. got7fsn_ti host cell lipid particle|host cell lipid adiposome|host cell lipid body jl 2009-10-15T03:05:06Z cellular_component owl:Class GO:0033655 biolink:NamedThing host cell cytoplasm part Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti cytoplasm component Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular_component owl:Class GO:0010723 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to iron Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus. got7fsn_ti biological_process owl:Class GO:0034395 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to iron Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus. got7fsn_ti regulation of specific transcription from RNA polymerase II promoter in response to iron biological_process owl:Class GO:0090532 biolink:NamedThing L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate. got7fsn_ti L-ascorbic acid biosynthesis via UDP-alpha-D-glucuronate This pathway occurs in most vertebrates, although not in guinea pigs and primates, including humans. tb 2013-02-06T15:31:01Z biological_process owl:Class GO:0019853 biolink:NamedThing L-ascorbic acid biosynthetic process The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. got7fsn_ti L-ascorbic acid formation|vitamin C biosynthesis|L-ascorbic acid anabolism|ascorbate biosynthesis|L-ascorbic acid biosynthesis|ascorbate biosynthetic process|vitamin C biosynthetic process|L-ascorbic acid synthesis MetaCyc:PWY-882 biological_process owl:Class GO:0009404 biolink:NamedThing toxin metabolic process The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. got7fsn_ti toxin metabolism biological_process owl:Class GO:0019748 biolink:NamedThing secondary metabolic process The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. got7fsn_ti secondary metabolite metabolic process|secondary metabolite metabolism|secondary metabolism Wikipedia:Secondary_metabolism biological_process owl:Class GO:0043891 biolink:NamedThing glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+. got7fsn_ti triosephosphate dehydrogenase (NAD(P))|glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)|triosephosphate dehydrogenase (NAD(P)+)|NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity|D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating) MetaCyc:GAPDHSYNEC-RXN|EC:1.2.1.59 molecular_function owl:Class GO:0016620 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti Reactome:R-HSA-1222583|EC:1.2.1.- molecular_function owl:Class GO:0045457 biolink:NamedThing ecdysteroid secretion The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. got7fsn_ti biological_process owl:Class GO:0035929 biolink:NamedThing steroid hormone secretion The regulated release of any steroid that acts as a hormone into the circulatory system. got7fsn_ti bf 2011-07-20T01:01:00Z biological_process owl:Class GO:0019151 biolink:NamedThing galactose 1-dehydrogenase activity Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+. got7fsn_ti beta-galactose dehydrogenase activity|D-galactose 1-dehydrogenase activity|NAD-dependent D-galactose dehydrogenase activity|D-galactose:NAD+ 1-oxidoreductase activity|D-galactose dehydrogenase activity RHEA:21296|MetaCyc:GALACTODEHYDROG-RXN|EC:1.1.1.48 molecular_function owl:Class GO:0033720 biolink:NamedThing (S)-mandelate dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor. got7fsn_ti MDH|(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity|L(+)-mandelate dehydrogenase activity MetaCyc:MANDELATE-DEHYDROGENASE-RXN|RHEA:15749|UM-BBD_reactionID:r1048|MetaCyc:MANDELATE-OXY-RXN|EC:1.1.99.31 molecular_function owl:Class GO:0016614 biolink:NamedThing oxidoreductase activity, acting on CH-OH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the CH-OH group of donors, other acceptors EC:1.1.-.-|Reactome:R-HSA-1500781 molecular_function owl:Class GO:0002182 biolink:NamedThing cytoplasmic translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm. got7fsn_ti hjd 2011-06-09T03:14:42Z biological_process owl:Class GO:0006414 biolink:NamedThing translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. got7fsn_ti translation elongation|protein synthesis elongation GO:0006442|GO:0006455 biological_process owl:Class GO:0150015 biolink:NamedThing apical proximal dendrite The dendrite of the dendritic tree, which emerges near the apical pole of a neuron, and which is the closest to the cell body of the neuron (the soma). got7fsn_ti bc 2017-12-21T12:09:26Z cellular_component owl:Class GO:1990635 biolink:NamedThing proximal dendrite The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma). got7fsn_ti sl 2015-02-10T22:57:16Z cellular_component owl:Class GO:0003904 biolink:NamedThing deoxyribodipyrimidine photo-lyase activity Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. got7fsn_ti CPD photolyase activity|phr A photolyase activity|deoxyribonucleic cyclobutane dipyrimidine photolyase activity|PhrB photolyase activity|deoxyribocyclobutadipyrimidine pyrimidine-lyase activity|PRE|photoreactivating enzyme activity|deoxyribonucleic photolyase activity|dipyrimidine photolyase (photosensitive)|photolyase activity|deoxyribodipyrimidine photolyase activity|DNA-photoreactivating enzyme|DNA cyclobutane dipyrimidine photolyase activity|deoxyribonucleate pyrimidine dimer lyase (photosensitive) MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN|RHEA:10672|EC:4.1.99.3 molecular_function owl:Class GO:0003913 biolink:NamedThing DNA photolyase activity Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. got7fsn_ti MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN molecular_function owl:Class GO:0046992 biolink:NamedThing oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y. got7fsn_ti oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors EC:1.21.-.- molecular_function owl:Class GO:0016491 biolink:NamedThing oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. got7fsn_ti oxidoreductase activity, acting on other substrates|redox activity Reactome:R-HSA-209960|Reactome:R-HSA-9024624|Reactome:R-HSA-8878581|Reactome:R-HSA-9027033|Reactome:R-HSA-3095889|Reactome:R-HSA-9020260|Reactome:R-HSA-9024630|Reactome:R-HSA-9020249|EC:1.-.-.-|Reactome:R-HSA-5662660|Reactome:R-HSA-8936442|Reactome:R-HSA-9026917|Reactome:R-HSA-209921|Reactome:R-HSA-1614362|Reactome:R-HSA-9693722|Reactome:R-HSA-390425|Reactome:R-HSA-9025007|Reactome:R-HSA-390438|Reactome:R-HSA-9026001 molecular_function owl:Class GO:0030169 biolink:NamedThing low-density lipoprotein particle binding Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. got7fsn_ti LDL binding molecular_function owl:Class GO:0071813 biolink:NamedThing lipoprotein particle binding Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. got7fsn_ti plasma lipoprotein particle binding|lipoprotein binding|plasma lipoprotein binding mah 2010-09-06T03:16:01Z molecular_function owl:Class GO:0071320 biolink:NamedThing cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. got7fsn_ti cellular response to cyclic AMP|cellular response to adenosine 3',5'-cyclophosphate|cellular response to 3',5' cAMP|cellular response to 3',5'-cAMP mah 2009-12-10T05:12:15Z biological_process owl:Class GO:0051591 biolink:NamedThing response to cAMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. got7fsn_ti response to 3',5' cAMP|response to adenosine 3',5'-cyclophosphate|response to cyclic AMP|response to 3',5'-cAMP biological_process owl:Class GO:0003233 biolink:NamedThing bulbus arteriosus morphogenesis The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber. got7fsn_ti dph 2009-10-13T11:07:30Z biological_process owl:Class GO:0003206 biolink:NamedThing cardiac chamber morphogenesis The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. got7fsn_ti heart chamber morphogenesis dph 2009-10-13T09:14:51Z biological_process owl:Class GO:0006314 biolink:NamedThing intron homing Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron. got7fsn_ti biological_process owl:Class GO:0006310 biolink:NamedThing DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. got7fsn_ti biological_process owl:Class GO:0071364 biolink:NamedThing cellular response to epidermal growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. got7fsn_ti cellular response to EGF stimulus mah 2009-12-11T03:05:34Z biological_process owl:Class GO:0070849 biolink:NamedThing response to epidermal growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. got7fsn_ti response to epidermal growth factor stimulus|response to EGF stimulus mah 2009-08-04T04:26:26Z biological_process owl:Class GO:0098579 biolink:NamedThing active sex chromosome A sex chromosome that has not been inactivated. got7fsn_ti cellular_component owl:Class GO:0000803 biolink:NamedThing sex chromosome A chromosome involved in sex determination. got7fsn_ti cellular_component owl:Class GO:0106283 biolink:NamedThing ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity Catalysis of the reaction: NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH. got7fsn_ti hjd 2020-07-29T17:52:44Z RHEA:42028 molecular_function owl:Class GO:0033764 biolink:NamedThing steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. got7fsn_ti molecular_function owl:Class GO:0097051 biolink:NamedThing establishment of protein localization to endoplasmic reticulum membrane The directed movement of a protein to a specific location in the endoplasmic reticulum membrane. got7fsn_ti establishment of protein localisation in endoplasmic reticulum membrane|establishment of protein localization in endoplasmic reticulum membrane pr 2011-05-04T05:55:26Z biological_process owl:Class GO:0090150 biolink:NamedThing establishment of protein localization to membrane The directed movement of a protein to a specific location in a membrane. got7fsn_ti establishment of protein localization in membrane|establishment of protein localisation in membrane tb 2009-12-08T03:18:51Z biological_process owl:Class GO:0008710 biolink:NamedThing 8-amino-7-oxononanoate synthase activity Catalysis of the reaction: L-alanine + H(+) + pimelyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA. got7fsn_ti 7-keto-8-aminopelargonic synthetase activity|7-keto-8-aminopelargonic acid synthetase activity|7-keto-8-amino-pelargonic acid synthetase activity|6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)|8-amino-7-ketopelargonate synthase activity|7-KAP synthetase activity|AONS activity|8-amino-7-oxopelargonate synthase activity KEGG_REACTION:R03210|RHEA:20712|MetaCyc:7KAPSYN-RXN|EC:2.3.1.47 molecular_function owl:Class GO:0016747 biolink:NamedThing acyltransferase activity, transferring groups other than amino-acyl groups Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring acyl groups other than amino-acyl groups|transferase activity, transferring groups other than amino-acyl groups https://github.com/geneontology/go-ontology/issues/20486 EC:2.3.1.- molecular_function owl:Class GO:0046838 biolink:NamedThing phosphorylated carbohydrate dephosphorylation The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it. got7fsn_ti biological_process owl:Class GO:0044262 biolink:NamedThing cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. got7fsn_ti cellular carbohydrate metabolism|main pathways of carbohydrate metabolic process|main pathways of carbohydrate metabolism GO:0006092 biological_process owl:Class GO:0031990 biolink:NamedThing mRNA export from nucleus in response to heat stress The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export. got7fsn_ti mRNA export from nucleus during heat stress|mRNA export from cell nucleus during heat stress biological_process owl:Class GO:0034605 biolink:NamedThing cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. got7fsn_ti cellular response to heat stress biological_process owl:Class GO:0060562 biolink:NamedThing epithelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. got7fsn_ti dph 2009-04-28T09:33:36Z biological_process owl:Class GO:0035239 biolink:NamedThing tube morphogenesis The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. got7fsn_ti biological_process owl:Class GO:0007072 biolink:NamedThing positive regulation of transcription involved in exit from mitosis Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. got7fsn_ti activation of transcription on exit from mitosis biological_process owl:Class GO:0022402 biolink:NamedThing cell cycle process The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. got7fsn_ti biological_process owl:Class GO:0075209 biolink:NamedThing induction by symbiont of host cAMP-mediated signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host cAMP-mediated signaling|positive regulation by symbiont of host cAMP-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075206". biological_process owl:Class GO:0075208 biolink:NamedThing modulation by symbiont of host cAMP-mediated signal transduction Any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host cAMP-mediated signaling Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont cAMP-mediated signal transduction ; GO:0075205". biological_process owl:Class GO:0102648 biolink:NamedThing D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate. got7fsn_ti MetaCyc:RXN-15790 molecular_function owl:Class GO:0016744 biolink:NamedThing transketolase or transaldolase activity Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring aldehyde or ketonic groups https://github.com/geneontology/go-ontology/issues/20486 GO:0016745 EC:2.2.1.- molecular_function owl:Class GO:0044630 biolink:NamedThing modulation of complement activation, lectin pathway in other organism A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism. got7fsn_ti regulation of complement activation, lectin pathway in other organism jl 2012-07-05T01:10:31Z biological_process owl:Class GO:0001868 biolink:NamedThing regulation of complement activation, lectin pathway Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation. got7fsn_ti regulation of complement cascade, lectin pathway biological_process owl:Class GO:0001626 biolink:NamedThing nociceptin receptor activity Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. got7fsn_ti OFQ receptor activity|nociceptin/orphanin-FQ receptor activity|orphanin-FQ receptor activity|ORPH receptor|X-opioid receptor activity molecular_function owl:Class GO:0004985 biolink:NamedThing G protein-coupled opioid receptor activity Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein. got7fsn_ti opioid receptor activity https://github.com/geneontology/go-ontology/issues/21110 molecular_function owl:Class GO:0030655 biolink:NamedThing beta-lactam antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. got7fsn_ti beta-lactam antibiotic catabolism|beta-lactam antibiotic degradation|beta-lactam antibiotic breakdown biological_process owl:Class GO:0072340 biolink:NamedThing cellular lactam catabolic process The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. got7fsn_ti cellular lactam breakdown|cellular lactam degradation|cellular lactam catabolism mah 2010-11-04T04:33:22Z biological_process owl:Class GO:0007269 biolink:NamedThing neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. got7fsn_ti neurotransmitter release|neurotransmitter secretory pathway A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. GO:0010554 biological_process owl:Class GO:0023061 biolink:NamedThing signal release The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. got7fsn_ti signal secretion 2010-02-16T09:30:50Z biological_process owl:Class GO:0046377 biolink:NamedThing colanic acid metabolic process The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues. got7fsn_ti colanic acid metabolism biological_process owl:Class GO:0044264 biolink:NamedThing cellular polysaccharide metabolic process The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. got7fsn_ti cellular glycan metabolic process|cellular glycan metabolism|cellular polysaccharide metabolism biological_process owl:Class GO:0007158 biolink:NamedThing neuron cell-cell adhesion The attachment of a neuron to another cell via adhesion molecules. got7fsn_ti neuron adhesion|neuronal cell adhesion biological_process owl:Class GO:0098609 biolink:NamedThing cell-cell adhesion The attachment of one cell to another cell via adhesion molecules. got7fsn_ti single organismal cell-cell adhesion dos 2014-04-16T13:40:03Z GO:0016337 biological_process owl:Class GO:0001894 biolink:NamedThing tissue homeostasis A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. got7fsn_ti tissue maintenance biological_process owl:Class GO:0060249 biolink:NamedThing anatomical structure homeostasis A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. got7fsn_ti anatomical structure maintenance biological_process owl:Class GO:0018220 biolink:NamedThing peptidyl-threonine palmitoylation The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine. got7fsn_ti peptidyl-threonine O-palmitoylation Palmitoylation of a non-terminal threonine residue always occurs on an oxygen (O) atom. RESID:AA0079 biological_process owl:Class GO:0018210 biolink:NamedThing peptidyl-threonine modification The modification of peptidyl-threonine. got7fsn_ti biological_process owl:Class GO:0098920 biolink:NamedThing retrograde trans-synaptic signaling by lipid Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. got7fsn_ti biological_process owl:Class GO:0099537 biolink:NamedThing trans-synaptic signaling Cell-cell signaling in either direction across the synaptic cleft. got7fsn_ti biological_process owl:Class GO:0021589 biolink:NamedThing cerebellum structural organization The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. got7fsn_ti cerebellum structural organisation biological_process owl:Class GO:0048532 biolink:NamedThing anatomical structure arrangement The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. got7fsn_ti structural organization|anatomical structure structural organization|anatomical structure organization|organization of an anatomical structure biological_process owl:Class GO:0097230 biolink:NamedThing cell motility in response to potassium ion Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus. got7fsn_ti potassium ion facilitation of cell motility|K+ facilitation of cell motility pr 2012-01-25T04:39:45Z biological_process owl:Class GO:0048870 biolink:NamedThing cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. got7fsn_ti movement of a cell|cell locomotion|cell movement biological_process owl:Class GO:0015195 biolink:NamedThing L-threonine transmembrane transporter activity Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid. got7fsn_ti threonine/serine:sodium symporter activity|L-threonine permease activity|L-threonine transporter activity GO:0015512 molecular_function owl:Class GO:0015175 biolink:NamedThing neutral amino acid transmembrane transporter activity Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. got7fsn_ti neutral amino acid transporter activity molecular_function owl:Class GO:0009041 biolink:NamedThing uridylate kinase activity Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. got7fsn_ti EC:2.7.4.22 molecular_function owl:Class GO:0016776 biolink:NamedThing phosphotransferase activity, phosphate group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). got7fsn_ti EC:2.7.4.- molecular_function owl:Class GO:0006869 biolink:NamedThing lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. got7fsn_ti biological_process owl:Class GO:0030724 biolink:NamedThing testicular fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome. got7fsn_ti testicular fusome organisation|testicular fusome organization and biogenesis biological_process owl:Class GO:0045478 biolink:NamedThing fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells. got7fsn_ti fusome organisation|fusome organization and biogenesis biological_process owl:Class GO:0032298 biolink:NamedThing positive regulation of DNA-dependent DNA replication initiation Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication. got7fsn_ti stimulation of DNA replication initiation|up-regulation of DNA replication initiation|negative regulation of DNA replication initiation|upregulation of DNA replication initiation|up regulation of DNA replication initiation|activation of DNA replication initiation biological_process owl:Class GO:0045740 biolink:NamedThing positive regulation of DNA replication Any process that activates or increases the frequency, rate or extent of DNA replication. got7fsn_ti stimulation of DNA replication|upregulation of DNA replication|up regulation of DNA replication|up-regulation of DNA replication|activation of DNA replication biological_process owl:Class GO:0099135 biolink:NamedThing chimeric colonial development Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype. got7fsn_ti biological_process owl:Class GO:0099120 biolink:NamedThing socially cooperative development The process whose specific outcome is the progression of a non-reproductive fruiting body over time, from its formation to the mature structure. A non-reproductive fruiting body is a colonial multicellular structure consisting of co-operating unicellular organisms, some of which are spores. An example of such a process is found in Dictyostelium discoideum and Myxococcus xanthus colonies. got7fsn_ti socially co-operative development|non-reproductive fruiting body development|colonial development https://github.com/geneontology/go-ontology/issues/20428 GO:0090702 biological_process owl:Class GO:0044277 biolink:NamedThing cell wall disassembly A process that results in the breakdown of the cell wall. got7fsn_ti cellular cell wall disassembly jl 2010-01-14T02:00:34Z GO:0060871 biological_process owl:Class GO:0071555 biolink:NamedThing cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. got7fsn_ti cellular cell wall organisation|cell wall organisation in other organism|cell wall organization at cellular level|cell wall organisation|cell wall organization and biogenesis|cellular cell wall organization|cell wall organization in other organism mah 2010-01-13T03:33:07Z GO:0044234|GO:0007047 biological_process owl:Class GO:0033880 biolink:NamedThing phenylacetyl-CoA hydrolase activity Catalysis of the reaction: H(2)O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate. got7fsn_ti phenylglyoxylyl-CoA hydrolase activity MetaCyc:3.1.2.25-RXN|RHEA:15337|EC:3.1.2.25|KEGG_REACTION:R07294 molecular_function owl:Class GO:0016289 biolink:NamedThing CoA hydrolase activity Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. got7fsn_ti Reactome:R-HSA-193385 molecular_function owl:Class GO:0006259 biolink:NamedThing DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. got7fsn_ti DNA metabolism|cellular DNA metabolism GO:0055132 biological_process owl:Class GO:0044260 biolink:NamedThing cellular macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. got7fsn_ti cellular macromolecule metabolism|cellular biopolymer metabolic process GO:0034960 biological_process owl:Class GO:0034210 biolink:NamedThing sterol deacetylation The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti biological_process owl:Class GO:0034208 biolink:NamedThing steroid deacetylation The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti biological_process owl:Class GO:0030866 biolink:NamedThing cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. got7fsn_ti cortical actin cytoskeleton stabilization|actin cortex stabilization|cortical resistance|cortical actin cytoskeleton organisation|cortical actin cytoskeleton organization and biogenesis GO:0033109 biological_process owl:Class GO:0030036 biolink:NamedThing actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. got7fsn_ti actin cytoskeleton organization and biogenesis|actin cytoskeleton organisation|actin modulating activity biological_process owl:Class GO:0036185 biolink:NamedThing 13-lipoxin reductase activity Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+. got7fsn_ti bf 2012-04-16T02:28:19Z Reactome:R-HSA-2161844 molecular_function owl:Class GO:0035597 biolink:NamedThing N6-isopentenyladenosine methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A). got7fsn_ti i6A methylthiotransferase activity bf 2010-11-12T01:26:58Z molecular_function owl:Class GO:0035596 biolink:NamedThing methylthiotransferase activity Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor. got7fsn_ti MTTase bf 2010-11-12T01:24:38Z molecular_function owl:Class GO:0042085 biolink:NamedThing 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate. got7fsn_ti molecular_function owl:Class GO:0008168 biolink:NamedThing methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule. got7fsn_ti methylase GO:0004480 Reactome:R-HSA-379387|Reactome:R-HSA-379464|Reactome:R-HSA-71286|EC:2.1.1.-|Reactome:R-HSA-6800149|Reactome:R-HSA-212269 molecular_function owl:Class GO:0032103 biolink:NamedThing positive regulation of response to external stimulus Any process that activates, maintains or increases the rate of a response to an external stimulus. got7fsn_ti stimulation of response to external stimulus|up regulation of response to external stimulus|activation of response to external stimulus|up-regulation of response to external stimulus|upregulation of response to external stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0032101 biolink:NamedThing regulation of response to external stimulus Any process that modulates the frequency, rate or extent of a response to an external stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0035127 biolink:NamedThing post-embryonic limb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. got7fsn_ti biological_process owl:Class GO:0035108 biolink:NamedThing limb morphogenesis The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping. got7fsn_ti limb bud morphogenesis biological_process owl:Class GO:0071175 biolink:NamedThing MAML2-RBP-Jkappa-ICN1 complex A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML2-RBP-Jkappa-Notch1 complex mah 2009-11-23T02:36:28Z cellular_component owl:Class GO:0006602 biolink:NamedThing creatinine catabolic process The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. got7fsn_ti creatinine degradation|creatinine catabolism|creatinine breakdown biological_process owl:Class GO:0009974 biolink:NamedThing zeinoxanthin epsilon hydroxylase activity Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene. got7fsn_ti MetaCyc:RXN-5962|RHEA:57352|EC:1.14.14.158 molecular_function owl:Class GO:0072374 biolink:NamedThing carotene epsilon hydroxylase activity Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene. got7fsn_ti mah 2010-11-19T03:57:55Z molecular_function owl:Class GO:0035526 biolink:NamedThing retrograde transport, plasma membrane to Golgi The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles. got7fsn_ti bf 2010-05-05T10:52:49Z biological_process owl:Class GO:0016192 biolink:NamedThing vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. got7fsn_ti vesicular transport|vesicle trafficking|vesicle transport|protein sorting along secretory pathway|nonselective vesicle transport GO:0006899 biological_process owl:Class GO:0106301 biolink:NamedThing arachidonic acid 5,6-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid. got7fsn_ti hjd 2020-08-28T19:08:45Z RHEA:49936 molecular_function owl:Class GO:0008392 biolink:NamedThing arachidonic acid epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. got7fsn_ti cytochrome P450 CYP2J5|cytochrome P450 CYP2J6 Reactome:R-HSA-211983 molecular_function owl:Class GO:0033371 biolink:NamedThing T cell secretory granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. got7fsn_ti T lymphocyte secretory granule organization|T-lymphocyte secretory granule maturation|T-lymphocyte secretory granule organization|T cell secretory granule organization and biogenesis|T cell secretory granule organisation|T-cell secretory granule organization biological_process owl:Class GO:0033363 biolink:NamedThing secretory granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. got7fsn_ti secretory granule organisation|secretory granule organization and biogenesis biological_process owl:Class GO:0030900 biolink:NamedThing forebrain development The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). got7fsn_ti prosencephalon development biological_process owl:Class GO:0055121 biolink:NamedThing response to high fluence blue light stimulus by blue high-fluence system Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2. got7fsn_ti response to high fluence blue light|response to high fluence blue light by bhf system biological_process owl:Class GO:0009637 biolink:NamedThing response to blue light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. got7fsn_ti response to blue light stimulus biological_process owl:Class GO:0045013 biolink:NamedThing carbon catabolite repression of transcription A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. got7fsn_ti negative regulation of transcription by carbon catabolites|carbon catabolite repression biological_process owl:Class GO:0045892 biolink:NamedThing negative regulation of transcription, DNA-templated Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. got7fsn_ti negative regulation of gene-specific transcription|downregulation of gene-specific transcription|negative regulation of cellular transcription, DNA-dependent|transcription repressor activity|inhibition of transcription, DNA-dependent|downregulation of transcription, DNA-dependent|down regulation of transcription, DNA-dependent|down-regulation of gene-specific transcription|inhibition of gene-specific transcription|down-regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|down regulation of gene-specific transcription GO:0016481|GO:0061021|GO:0032582 biological_process owl:Class GO:0035799 biolink:NamedThing ureter maturation A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. got7fsn_ti bf 2011-04-14T01:13:39Z biological_process owl:Class GO:0048799 biolink:NamedThing animal organ maturation A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. got7fsn_ti biological_process owl:Class GO:0048789 biolink:NamedThing cytoskeletal matrix organization at active zone The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane. got7fsn_ti cytoskeletal matrix organisation at active zone biological_process owl:Class GO:0030865 biolink:NamedThing cortical cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. got7fsn_ti cortical cytoskeleton organization and biogenesis|cortical cytoskeleton organisation biological_process owl:Class GO:0071668 biolink:NamedThing plant-type cell wall assembly The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall. got7fsn_ti plant cell wall assembly mah 2010-02-15T02:19:39Z biological_process owl:Class GO:0070726 biolink:NamedThing cell wall assembly The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells. got7fsn_ti mah 2009-06-16T03:58:20Z biological_process owl:Class GO:0085039 biolink:NamedThing hyphal membrane A host-derived membrane surrounding the symbiont hypha during infection. got7fsn_ti extra-invasive hyphal membrane https://github.com/geneontology/go-ontology/issues/19013 jl 2010-07-27T04:19:46Z cellular_component owl:Class GO:0033644 biolink:NamedThing host cell membrane Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti cellular_component owl:Class GO:0072154 biolink:NamedThing proximal convoluted tubule segment 1 cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney. got7fsn_ti S1 cell fate commitment mah 2010-02-24T02:18:19Z biological_process owl:Class GO:0045165 biolink:NamedThing cell fate commitment The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. got7fsn_ti Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. biological_process owl:Class GO:0051332 biolink:NamedThing meiotic S phase The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle. got7fsn_ti S phase of meiotic cell cycle|S-phase of meiotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class GO:0051320 biolink:NamedThing S phase The cell cycle phase, following G1, during which DNA synthesis takes place. got7fsn_ti S-phase Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:S_phase biological_process owl:Class GO:0036268 biolink:NamedThing swimming Self-propelled movement of an organism from one location to another through water, often by means of active fin movement. got7fsn_ti For behavioral aspects of swimming, consider instead annotating to 'swimming behavior ; GO:0036269'. bf 2012-07-04T10:12:24Z biological_process owl:Class GO:0040011 biolink:NamedThing locomotion Self-propelled movement of a cell or organism from one location to another. got7fsn_ti biological_process owl:Class GO:0090326 biolink:NamedThing positive regulation of locomotion involved in locomotory behavior Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. got7fsn_ti tb 2010-05-14T10:26:58Z biological_process owl:Class GO:0040017 biolink:NamedThing positive regulation of locomotion Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. got7fsn_ti activation of locomotion|up regulation of locomotion|up-regulation of locomotion|stimulation of locomotion|upregulation of locomotion biological_process owl:Class GO:0070054 biolink:NamedThing mRNA splicing, via endonucleolytic cleavage and ligation Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. got7fsn_ti cytosolic mRNA splicing Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. GO:0061012 biological_process owl:Class GO:0000394 biolink:NamedThing RNA splicing, via endonucleolytic cleavage and ligation Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. got7fsn_ti mRNA splicing Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. biological_process owl:Class GO:0015026 biolink:NamedThing coreceptor activity Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. got7fsn_ti coreceptor, soluble ligand activity|coreceptor, insoluble ligand activity GO:0015028|GO:0015027 molecular_function owl:Class GO:0038023 biolink:NamedThing signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. got7fsn_ti receptor activity|signalling receptor activity|receptor activity involved in signal transduction bf 2011-08-01T02:45:27Z GO:0019041|GO:0004872 molecular_function owl:Class GO:0042318 biolink:NamedThing penicillin biosynthetic process The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. got7fsn_ti penicillin formation|penicillin anabolism|penicillin biosynthesis|penicillin synthesis biological_process owl:Class GO:0044629 biolink:NamedThing negative regulation of complement activation, classical pathway in other organism Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism. got7fsn_ti jl 2012-07-05T01:03:25Z biological_process owl:Class GO:0045959 biolink:NamedThing negative regulation of complement activation, classical pathway Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway. got7fsn_ti inhibition of complement activation, classical pathway|negative regulation of complement cascade, classical pathway|downregulation of complement activation, classical pathway|down regulation of complement activation, classical pathway|down-regulation of complement activation, classical pathway biological_process owl:Class GO:0048933 biolink:NamedThing afferent axon development in posterior lateral line nerve The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve. got7fsn_ti biological_process owl:Class GO:0048893 biolink:NamedThing afferent axon development in lateral line nerve The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve. got7fsn_ti biological_process owl:Class GO:0004379 biolink:NamedThing glycylpeptide N-tetradecanoyltransferase activity Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. got7fsn_ti N-myristoyltransferase activity|protein N-myristoyltransferase activity|peptide N-tetradecanoyltransferase activity|myristoyl-CoA-protein N-myristoyltransferase activity|tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity|myristoylating enzymes|peptide N-myristoyltransferase activity|myristoyl-coenzyme A:protein N-myristoyl transferase activity GO:0019106 Reactome:R-HSA-184392|Reactome:R-HSA-2534087|MetaCyc:2.3.1.97-RXN|RHEA:15521|EC:2.3.1.97 molecular_function owl:Class GO:0016410 biolink:NamedThing N-acyltransferase activity Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. got7fsn_ti Reactome:R-HSA-177160 molecular_function owl:Class GO:0000920 biolink:NamedThing septum digestion after cytokinesis The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. got7fsn_ti mitotic cytokinetic cell separation|cell separation following cytokinesis|cytokinetic cell separation|daughter cell separation|cell separation after cytokinesis This term should not be used to describe the last step of cytokinesis in organisms without a cell wall, ie, the cell resealing of the plasma membrane via abscission. Consider annotating to 'GO:0061952 midbody abscission' to capture this process. GO:1902409|GO:2000695 biological_process owl:Class GO:0009987 biolink:NamedThing cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. got7fsn_ti cell growth and/or maintenance|single-organism cellular process|cellular physiological process|cell physiology jl 2012-12-11T16:56:55Z GO:0044763|GO:0050875|GO:0008151 biological_process owl:Class GO:0070004 biolink:NamedThing cysteine-type exopeptidase activity Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. got7fsn_ti molecular_function owl:Class GO:0008238 biolink:NamedThing exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. got7fsn_ti exoprotease activity molecular_function owl:Class GO:0071170 biolink:NamedThing site-specific DNA replication termination A DNA replication termination process that takes place at a specific termination site. got7fsn_ti See also the biological process term 'replication fork arrest ; GO:0043111' and its children. mah 2009-11-20T01:07:30Z biological_process owl:Class GO:0006274 biolink:NamedThing DNA replication termination The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. got7fsn_ti biological_process owl:Class GO:0034321 biolink:NamedThing alcohol O-octanoyltransferase activity Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester. got7fsn_ti molecular_function owl:Class GO:0016413 biolink:NamedThing O-acetyltransferase activity Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class GO:0051263 biolink:NamedThing microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain. got7fsn_ti microcin E492 synthesis by siderophore ester modification of peptidyl-serine|microcin E492 anabolism by siderophore ester modification of peptidyl-serine|microcin E492 formation by siderophore ester modification of peptidyl-serine RESID:AA0374 biological_process owl:Class GO:0018209 biolink:NamedThing peptidyl-serine modification The modification of peptidyl-serine. got7fsn_ti biological_process owl:Class GO:0047791 biolink:NamedThing cucurbitacin delta23-reductase activity Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+. got7fsn_ti cucurbitacin D23-reductase activity|NAD(P)H: cucurbitacin B delta23-oxidoreductase activity|23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity|cucurbitacin delta(23) reductase activity EC:1.3.1.5|MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN molecular_function owl:Class GO:0016628 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti Reactome:R-HSA-9661745|Reactome:R-HSA-4419979|EC:1.3.1.-|Reactome:R-HSA-9661726|Reactome:R-HSA-4755572 molecular_function owl:Class GO:0102616 biolink:NamedThing oryzalexin A synthase activity Catalysis of the reaction: oryzalexin D + NAD(P) <=> oryzalexin A + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-15464 molecular_function owl:Class GO:0021819 biolink:NamedThing layer formation in cerebral cortex The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. got7fsn_ti cerebral cortex lamination biological_process owl:Class GO:0048646 biolink:NamedThing anatomical structure formation involved in morphogenesis The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. got7fsn_ti formation of an anatomical structure involved in morphogenesis Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. biological_process owl:Class GO:0001306 biolink:NamedThing age-dependent response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism. got7fsn_ti biological_process owl:Class GO:0006979 biolink:NamedThing response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. got7fsn_ti biological_process owl:Class GO:0050261 biolink:NamedThing ribose isomerase activity Catalysis of the reaction: ribofuranose = D-ribulose. got7fsn_ti D-ribose isomerase activity|D-ribose ketol-isomerase activity|D-ribose aldose-ketose-isomerase activity MetaCyc:RIBOSE-ISOMERASE-RXN|KEGG_REACTION:R01081|RHEA:20796|EC:5.3.1.20 molecular_function owl:Class GO:0016861 biolink:NamedThing intramolecular oxidoreductase activity, interconverting aldoses and ketoses Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. got7fsn_ti intramolecular isomerase activity, interconverting aldoses and ketoses EC:5.3.1.- molecular_function owl:Class GO:1990756 biolink:NamedThing ubiquitin ligase-substrate adaptor activity The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins. got7fsn_ti protein binding, bridging involved in substrate recognition for ubiquitination|ubiquitin ligase substrate adaptor https://github.com/geneontology/go-ontology/issues/18655 vw 2015-06-01T08:35:16Z molecular_function owl:Class GO:0030674 biolink:NamedThing protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. got7fsn_ti protein binding, bridging|protein-protein adaptor https://github.com/geneontology/go-ontology/issues/19409|https://github.com/geneontology/go-ontology/issues/18655 molecular_function owl:Class GO:0004990 biolink:NamedThing oxytocin receptor activity Combining with oxytocin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class GO:0008528 biolink:NamedThing G protein-coupled peptide receptor activity Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti peptide receptor activity, G protein coupled|peptide receptor activity, G-protein coupled|G-protein coupled peptide receptor activity|G protein coupled peptide receptor activity molecular_function owl:Class GO:0140317 biolink:NamedThing export across cell outer membrane The directed movement of a substance across the outer membrane in cells with two membranes. got7fsn_ti pg 2019-04-01T08:12:23Z biological_process owl:Class GO:0055085 biolink:NamedThing transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti membrane transport|ATP hydrolysis coupled transmembrane transport Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. tb 2015-10-21T13:22:47Z GO:0090662 biological_process owl:Class GO:0072559 biolink:NamedThing NLRP3 inflammasome complex An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. got7fsn_ti NALP3 inflammasome complex mah 2011-01-27T12:04:30Z cellular_component owl:Class GO:0043761 biolink:NamedThing archaetidylserine synthase activity Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP. got7fsn_ti CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity|CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity EC:2.7.8.38 molecular_function owl:Class GO:0016780 biolink:NamedThing phosphotransferase activity, for other substituted phosphate groups Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). got7fsn_ti Reactome:R-HSA-162742|Reactome:R-HSA-163069|EC:2.7.8.- molecular_function owl:Class GO:0000783 biolink:NamedThing nuclear telomere cap complex A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. got7fsn_ti Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. cellular_component owl:Class GO:0000782 biolink:NamedThing telomere cap complex A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. got7fsn_ti Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. cellular_component owl:Class GO:0102657 biolink:NamedThing 1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.42|MetaCyc:RXN-1728 molecular_function owl:Class GO:0016717 biolink:NamedThing oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. got7fsn_ti EC:1.14.19.- molecular_function owl:Class GO:0048733 biolink:NamedThing sebaceous gland development The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class GO:0048732 biolink:NamedThing gland development The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. got7fsn_ti biological_process owl:Class GO:0035185 biolink:NamedThing preblastoderm mitotic cell cycle The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. got7fsn_ti biological_process owl:Class GO:0045448 biolink:NamedThing mitotic cell cycle, embryonic The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo. got7fsn_ti biological_process owl:Class GO:0103057 biolink:NamedThing gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate <=> H+ + gibberellin A20 + 2 carbon dioxide + succinate. got7fsn_ti MetaCyc:RXN1F-169 molecular_function owl:Class GO:0016706 biolink:NamedThing 2-oxoglutarate-dependent dioxygenase activity Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. got7fsn_ti 2-oxoglutarate dioxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0010302 Reactome:R-HSA-1234164|Reactome:R-HSA-6783455|EC:1.14.11.- molecular_function owl:Class GO:0036450 biolink:NamedThing polyuridylation-dependent decapping of nuclear-transcribed mRNA Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end. got7fsn_ti uridylation-dependent decapping of nuclear-transcribed mRNA bf 2013-11-04T11:37:28Z biological_process owl:Class GO:0031087 biolink:NamedThing deadenylation-independent decapping of nuclear-transcribed mRNA Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening. got7fsn_ti deadenylation-independent decapping of nuclear mRNA|deadenylylation-independent decapping biological_process owl:Class GO:0022406 biolink:NamedThing membrane docking The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. got7fsn_ti membrane docking biological_process owl:Class GO:0003332 biolink:NamedThing negative regulation of extracellular matrix constituent secretion Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. got7fsn_ti dph 2009-11-02T02:13:49Z biological_process owl:Class GO:1903054 biolink:NamedThing negative regulation of extracellular matrix organization Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. got7fsn_ti downregulation of extracellular matrix organisation|downregulation of extracellular matrix organization|down regulation of extracellular matrix organization|downregulation of extracellular matrix organization and biogenesis|down regulation of extracellular matrix organisation|down regulation of extracellular matrix organization and biogenesis|inhibition of extracellular matrix organization and biogenesis|inhibition of extracellular matrix organisation|negative regulation of extracellular matrix organization and biogenesis|negative regulation of extracellular matrix organisation|down-regulation of extracellular matrix organisation|down-regulation of extracellular matrix organization|inhibition of extracellular matrix organization|down-regulation of extracellular matrix organization and biogenesis rl 2014-05-23T17:15:47Z biological_process owl:Class GO:0015474 biolink:NamedThing autotransporter activity Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively. got7fsn_ti molecular_function owl:Class GO:0015288 biolink:NamedThing porin activity Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. got7fsn_ti porin|outer membrane exporter porin Wikipedia:Porin_(protein) molecular_function owl:Class GO:0018546 biolink:NamedThing nitrobenzene nitroreductase activity Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O. got7fsn_ti MetaCyc:RXN-8815|RHEA:52884|UM-BBD_enzymeID:e0245 molecular_function owl:Class GO:0016657 biolink:NamedThing oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group. got7fsn_ti oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor EC:1.6.6.- molecular_function owl:Class GO:0002301 biolink:NamedThing CD4-positive, alpha-beta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti CD4-positive, alpha-beta intraepithelial T-cell differentiation|CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation|CD4-positive, alpha-beta intraepithelial T cell development|CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:0044468 biolink:NamedThing envenomation resulting in modulation of blood coagulation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism. got7fsn_ti envenomation resulting in regulation of blood coagulation in other organism jl 2012-01-19T01:24:10Z biological_process owl:Class GO:0035738 biolink:NamedThing envenomation resulting in modulation of process in other organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism. got7fsn_ti envenomation resulting in modification of morphology or physiology of other organism https://github.com/geneontology/go-ontology/issues/18605 bf 2011-03-17T10:59:27Z biological_process owl:Class GO:0007019 biolink:NamedThing microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a microtubule. got7fsn_ti microtubule depolymerization during nuclear congression|microtubule catastrophe|microtubule shortening|microtubule disassembly biological_process owl:Class GO:0031109 biolink:NamedThing microtubule polymerization or depolymerization Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. got7fsn_ti biological_process owl:Class GO:0035615 biolink:NamedThing clathrin adaptor activity Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. got7fsn_ti clathrin-associated adaptor activity bf 2010-12-01T11:17:57Z molecular_function owl:Class GO:0140312 biolink:NamedThing cargo adaptor activity Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery. got7fsn_ti endocytic adaptor activity https://github.com/geneontology/go-ontology/issues/19454|https://github.com/geneontology/go-ontology/issues/17553 pg 2019-03-26T17:01:45Z GO:0098748 molecular_function owl:Class GO:0061049 biolink:NamedThing cell growth involved in cardiac muscle cell development The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. got7fsn_ti cardiomyocyte growth|heart muscle cell growth|cardiac muscle cell hypertrophy dph 2010-02-25T12:56:07Z biological_process owl:Class GO:0048588 biolink:NamedThing developmental cell growth The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. got7fsn_ti developmental growth of a unicellular organism biological_process owl:Class GO:0044174 biolink:NamedThing host cell endosome A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation. got7fsn_ti host endosome jl 2009-09-04T03:02:01Z cellular_component owl:Class GO:0033648 biolink:NamedThing host intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti host intracellular membrane-enclosed organelle cellular_component owl:Class GO:0060364 biolink:NamedThing frontal suture morphogenesis The process in which the frontal suture is generated and organized. got7fsn_ti interfrontal suture morphogenesis biological_process owl:Class GO:0060363 biolink:NamedThing cranial suture morphogenesis The process in which any suture between cranial bones is generated and organized. got7fsn_ti biological_process owl:Class GO:0052792 biolink:NamedThing endo-xylogalacturonan hydrolase activity Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position. got7fsn_ti endo-galacturonase activity ai 2011-10-05T03:57:30Z molecular_function owl:Class GO:0043426 biolink:NamedThing MRF binding Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. got7fsn_ti myogenin binding|Myf5 binding|MyoD binding|Mrf4 binding GO:0051577|GO:0051579|GO:0051576|GO:0051578 molecular_function owl:Class GO:0043425 biolink:NamedThing bHLH transcription factor binding Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. got7fsn_ti molecular_function owl:Class GO:0048160 biolink:NamedThing primary follicle stage The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large. got7fsn_ti mammalian oogenesis stage 3 biological_process owl:Class GO:0022605 biolink:NamedThing mammalian oogenesis stage A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell. got7fsn_ti mammalian oogenesis process biological_process owl:Class GO:0034746 biolink:NamedThing APC-IQGAP1-CLIP-170 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration. got7fsn_ti Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class GO:0050021 biolink:NamedThing L-arabinonolactonase activity Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+). got7fsn_ti L-arabinono-1,4-lactone lactonohydrolase activity EC:3.1.1.15|RHEA:16217|MetaCyc:L-ARABINONOLACTONASE-RXN|KEGG_REACTION:R02526 molecular_function owl:Class GO:0052689 biolink:NamedThing carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond. got7fsn_ti carboxylic acid esterase activity|vitamin A esterase|carboxyesterase activity|carboxylic esterase activity|carboxyl ester hydrolase activity|alpha-carboxylesterase activity|cocaine esterase activity|esterase B|procaine esterase activity|serine esterase activity|B-esterase activity|triacetin esterase|ali-esterase activity|carboxylate esterase activity|nonspecific carboxylesterase activity|carboxylesterase activity|carboxylic ester hydrolase activity|esterase A GO:0004759|GO:0004302|GO:0016789|GO:0004091 UM-BBD_reactionID:r1025|RHEA:21164|Reactome:R-HSA-5693691|EC:3.1.1.1|KEGG_REACTION:R00630|MetaCyc:CARBOXYLESTERASE-RXN|Reactome:R-HSA-9619024|Reactome:R-HSA-8937442 molecular_function owl:Class GO:0034640 biolink:NamedThing establishment of mitochondrion localization by microtubule attachment The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization. got7fsn_ti mitochondrial localization by microtubule attachment|establishment of mitochondrion localisation by microtubule attachment|mitochondrial migration by microtubule attachment|mitochondrion migration by microtubule attachment biological_process owl:Class GO:0034643 biolink:NamedThing establishment of mitochondrion localization, microtubule-mediated The directed movement of the mitochondrion to a specific location, by a process involving microtubules. got7fsn_ti establishment of mitochondrion localisation, microtubule-mediated|mitochondrial localization, microtubule-mediated|microtubule-mediated mitochondrion localization biological_process owl:Class GO:0002097 biolink:NamedThing tRNA wobble base modification The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified. got7fsn_ti biological_process owl:Class GO:0006400 biolink:NamedThing tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. got7fsn_ti tRNA editing The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. GO:0016549 biological_process owl:Class GO:0050461 biolink:NamedThing L-mimosine synthase activity Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate. got7fsn_ti O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)|O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity|3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity|O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity EC:2.5.1.52|KEGG_REACTION:R04091|RHEA:12693|MetaCyc:RXN-7461 molecular_function owl:Class GO:0016765 biolink:NamedThing transferase activity, transferring alkyl or aryl (other than methyl) groups Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring alkyl or aryl groups, other than methyl groups GO:0016766 Reactome:R-HSA-4755545|EC:2.5.1.-|Reactome:R-HSA-6782893|Reactome:R-HSA-4419978 molecular_function owl:Class GO:0000774 biolink:NamedThing adenyl-nucleotide exchange factor activity Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. got7fsn_ti Reactome:R-HSA-5252079 molecular_function owl:Class GO:0060590 biolink:NamedThing ATPase regulator activity Binds to and modulates the activity of an ATP hydrolysis activity. got7fsn_ti ATP hydrolysis regulator activity https://github.com/geneontology/go-ontology/issues/20955 dph 2009-05-08T02:49:24Z molecular_function owl:Class GO:0106166 biolink:NamedThing spindle pole body-nuclear membrane anchor activity The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body. got7fsn_ti spindle pole body nuclear membrane anchor activity|nuclear membrane-spindle pole body anchor activity https://github.com/geneontology/go-ontology/issues/20606|https://github.com/geneontology/go-ontology/issues/19119 hjd 2019-01-18T15:57:42Z molecular_function owl:Class GO:0140475 biolink:NamedThing spindle pole body anchor activity The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way. got7fsn_ti pg 2020-06-23T15:54:56Z molecular_function owl:Class GO:0061421 biolink:NamedThing positive regulation of transcription by oleic acid Any process involving oleic acid that activates or increases the rate of transcription. got7fsn_ti dph 2012-01-25T10:11:39Z biological_process owl:Class GO:0045991 biolink:NamedThing carbon catabolite activation of transcription A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. got7fsn_ti positive regulation of transcription by carbon catabolites biological_process owl:Class GO:0019250 biolink:NamedThing aerobic cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen. got7fsn_ti aerobic cobalamin formation|cobalamin biosynthesis, aerobic|vitamin B12 biosynthetic process, aerobic|aerobic cobalamin anabolism|aerobic cobalamin biosynthesis|cobalamin biosynthetic process, aerobic|vitamin B12 biosynthesis, aerobic|aerobic vitamin B12 biosynthetic process|aerobic vitamin B12 biosynthesis|aerobic cobalamin synthesis MetaCyc:P381-PWY biological_process owl:Class GO:0009236 biolink:NamedThing cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. got7fsn_ti vitamin B12 biosynthesis|cobalamin biosynthesis|vitamin B12 biosynthetic process|cobalamin formation|cobalamin anabolism|cobalamin synthesis biological_process owl:Class GO:0000159 biolink:NamedThing protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. got7fsn_ti PP2A-pi|protein phosphatase 2 complex|PP2a-protector|PP2A complex cellular_component owl:Class GO:0008287 biolink:NamedThing protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. got7fsn_ti cellular_component owl:Class GO:0102402 biolink:NamedThing 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose. got7fsn_ti MetaCyc:RXN-13694|EC:3.2.1.149 molecular_function owl:Class GO:0017151 biolink:NamedThing DEAD/H-box RNA helicase binding Binding to a DEAD/H-box RNA helicase. got7fsn_ti molecular_function owl:Class GO:0019899 biolink:NamedThing enzyme binding Binding to an enzyme, a protein with catalytic activity. got7fsn_ti molecular_function owl:Class GO:0052092 biolink:NamedThing positive regulation by symbiont of nutrient release from host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti stimulation by symbiont of nutrient release from host|activation by symbiont of nutrient release from host|promotion of nutrient release from host|up-regulation by symbiont of nutrient release from host|upregulation by symbiont of nutrient release from host|up regulation by symbiont of nutrient release from host biological_process owl:Class GO:0052520 biolink:NamedThing positive regulation by organism of nutrient release from other organism involved in symbiotic interaction Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti positive regulation by organism of nutrient release from other organism during symbiotic interaction|promotion of nutrient release from other organism|stimulation by organism of nutrient release from other organism during symbiotic interaction|activation by organism of nutrient release from other organism during symbiotic interaction|upregulation by organism of nutrient release from other organism during symbiotic interaction|up-regulation by organism of nutrient release from other organism during symbiotic interaction|up regulation by organism of nutrient release from other organism during symbiotic interaction biological_process owl:Class GO:0047257 biolink:NamedThing diglucosyl diacylglycerol synthase activity Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol. got7fsn_ti DGlcDAG synthase activity|monoglucosyl diacylglycerol (1->2) glucosyltransferase activity|MGlcDAG (1->2) glucosyltransferase activity|UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity|diglucosyl diacylglycerol (DGlcDAG) synthase activity MetaCyc:2.4.1.208-RXN|RHEA:19165|EC:2.4.1.208 molecular_function owl:Class GO:0008194 biolink:NamedThing UDP-glycosyltransferase activity Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. got7fsn_ti Reactome:R-HSA-162730 molecular_function owl:Class GO:0043259 biolink:NamedThing laminin-10 complex A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains. got7fsn_ti laminin-511 complex cellular_component owl:Class GO:0043256 biolink:NamedThing laminin complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes. got7fsn_ti cellular_component owl:Class GO:1990447 biolink:NamedThing U2 snRNP binding Binding to a U2 small nuclear ribonucleoprotein particle. got7fsn_ti mah 2014-08-06T09:33:38Z molecular_function owl:Class GO:0070990 biolink:NamedThing snRNP binding Binding to a small nuclear ribonucleoprotein particle. got7fsn_ti mah 2009-10-29T03:54:25Z molecular_function owl:Class GO:0002261 biolink:NamedThing mucosal lymphocyte homeostasis The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti biological_process owl:Class GO:0002260 biolink:NamedThing lymphocyte homeostasis The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti biological_process owl:Class GO:0022881 biolink:NamedThing protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti N-acetylgalactosamine PTS transporter activity molecular_function owl:Class GO:0008982 biolink:NamedThing protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti phosphotransferase, phosphohistidinoprotein-hexose activity|gene glC proteins|protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity|phosphotransfer-driven group translocator|gene bglC RNA formation factors|PTS permease activity|protein-Np-phosphohistidine-sugar phosphotransferase activity|protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity|PTS transporter|phosphoenolpyruvate-sugar phosphotransferase enzyme II|sucrose phosphotransferase system II|protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity|ribonucleic acid formation factor, gene glC|phosphoprotein factor-hexose phosophotransferase activity|group translocator activity|enzyme II of the phosphotransferase system|PEP-dependent phosphotransferase enzyme II|phosphohistidinoprotein-hexose phosphotransferase activity|protein-Npi-phosphohistidine-sugar phosphotransferase activity|phosphohistidinoprotein-hexose phosphoribosyltransferase activity|enzyme IIl4ac|PEP--sugar phosphotransferase enzyme II activity|protein, specific or class, gene bglC GO:0015455|GO:0015456 MetaCyc:2.7.1.69-RXN|EC:2.7.1.69 molecular_function owl:Class GO:1990147 biolink:NamedThing talin binding Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. got7fsn_ti hjd 2013-07-25T19:49:53Z molecular_function owl:Class GO:0008092 biolink:NamedThing cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). got7fsn_ti molecular_function owl:Class GO:0004517 biolink:NamedThing nitric-oxide synthase activity Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. got7fsn_ti endothelium-derived relaxing factor synthase activity|NO synthase activity|nitric oxide synthetase activity|nitric-oxide synthetase activity|NADPH-diaphorase activity|nitric oxide synthase activity|L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity|endothelium-derived relaxation factor-forming enzyme activity Reactome:R-HSA-418436|RHEA:19897|Reactome:R-HSA-202127|EC:1.14.13.39|MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN molecular_function owl:Class GO:0140060 biolink:NamedThing axon arborization The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches. got7fsn_ti pg 2017-07-12T15:17:22Z biological_process owl:Class GO:0007409 biolink:NamedThing axonogenesis De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. got7fsn_ti axon morphogenesis|neuron long process generation|axon growth Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon). GO:0007410 biological_process owl:Class GO:0061778 biolink:NamedThing intracellular chloride channel activity Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. got7fsn_ti dph 2016-08-02T09:37:15Z molecular_function owl:Class GO:0005254 biolink:NamedThing chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. got7fsn_ti Reactome:R-HSA-975340|Reactome:R-HSA-975449|Reactome:R-HSA-427570|Reactome:R-HSA-2744349 molecular_function owl:Class GO:0046917 biolink:NamedThing triphosphoribosyl-dephospho-CoA synthase activity Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. got7fsn_ti ATP:dephospho-CoA 5-triphosphoribosyl transferase activity|ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity|CitG activity|2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity EC:2.4.2.52|RHEA:15117|MetaCyc:2.7.8.25-RXN molecular_function owl:Class GO:0003222 biolink:NamedThing ventricular trabecula myocardium morphogenesis The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. got7fsn_ti trabecula carnea morphogenesis dph 2009-10-13T10:33:00Z biological_process owl:Class GO:0061384 biolink:NamedThing heart trabecula morphogenesis The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. got7fsn_ti dph 2010-12-02T08:54:20Z biological_process owl:Class GO:0010196 biolink:NamedThing nonphotochemical quenching The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage. got7fsn_ti biological_process owl:Class GO:1990066 biolink:NamedThing energy quenching The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted by nonphotochemical quenching or chlorophyll fluorescence. got7fsn_ti tb 2013-03-27T21:02:00Z biological_process owl:Class GO:0070669 biolink:NamedThing response to interleukin-2 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus. got7fsn_ti response to IL-2 mah 2009-05-29T09:59:43Z biological_process owl:Class GO:0034097 biolink:NamedThing response to cytokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. got7fsn_ti response to cytokine stimulus biological_process owl:Class GO:1990768 biolink:NamedThing gastric mucosal blood circulation The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. got7fsn_ti stomach mucosal blood circulation sl 2015-06-10T20:11:09Z biological_process owl:Class GO:0008015 biolink:NamedThing blood circulation The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. got7fsn_ti hemolymph circulation GO:0070261 biological_process owl:Class GO:0048584 biolink:NamedThing positive regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. got7fsn_ti activation of response to stimulus|stimulation of response to stimulus|up-regulation of response to stimulus|up regulation of response to stimulus|upregulation of response to stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0048583 biolink:NamedThing regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0006081 biolink:NamedThing cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. got7fsn_ti alkanal metabolic process|alkanal metabolism|aldehyde metabolism biological_process owl:Class GO:0050984 biolink:NamedThing peptidyl-serine sulfation The sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine. got7fsn_ti RESID:AA0361 biological_process owl:Class GO:0070857 biolink:NamedThing regulation of bile acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. got7fsn_ti regulation of bile acid synthesis|regulation of bile acid biosynthesis|regulation of bile acid anabolism|regulation of bile acid formation mah 2009-08-14T03:09:02Z biological_process owl:Class GO:0010565 biolink:NamedThing regulation of cellular ketone metabolic process Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. got7fsn_ti biological_process owl:Class GO:0072297 biolink:NamedThing specification of metanephric proximal tubule identity The process in which the proximal tubule of the metanephric nephron acquires its identity. got7fsn_ti mah 2010-04-09T04:08:20Z biological_process owl:Class GO:0031031 biolink:NamedThing positive regulation of septation initiation signaling Any process that activates or increases the frequency, rate or extent of septation initiation signaling. got7fsn_ti upregulation of septation initiation signaling|stimulation of septation initiation signaling|positive regulation of septation initiation signalling|positive regulation of septation initiation signaling cascade|up regulation of septation initiation signaling|up-regulation of septation initiation signaling|positive regulation of septation initiation network|activation of septation initiation signaling biological_process owl:Class GO:0010973 biolink:NamedThing positive regulation of division septum assembly Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. got7fsn_ti positive regulation of division septum formation|positive regulation of division septum formation involved in cell cycle cytokinesis|upregulation of mitotic division septum assembly tb 2009-06-01T10:27:15Z GO:1901912|GO:1902470 biological_process owl:Class GO:0070091 biolink:NamedThing glucagon secretion The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). got7fsn_ti biological_process owl:Class GO:0030072 biolink:NamedThing peptide hormone secretion The regulated release of a peptide hormone from a cell. got7fsn_ti biological_process owl:Class GO:0043721 biolink:NamedThing 4-hydroxybutanoyl-CoA dehydratase activity Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O. got7fsn_ti gamma-hydroxybutyryl-CoA dehydratase activity|4-hydroxybutanoyl-CoA hydro-lyase|4-hydroxybutyryl-CoA dehydratase activity|gamma-hydroxybutanoyl-CoA dehydratase activity RHEA:26530|KEGG_REACTION:R05337|MetaCyc:RXN-8890|EC:4.2.1.120 molecular_function owl:Class GO:0016836 biolink:NamedThing hydro-lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. got7fsn_ti Reactome:R-HSA-9014627|EC:4.2.1.- molecular_function owl:Class GO:0060894 biolink:NamedThing limb spinous cell fate specification The process in which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti dph 2009-08-13T01:46:23Z biological_process owl:Class GO:0009957 biolink:NamedThing epidermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti hypodermal cell fate specification GO:0043356 biological_process owl:Class GO:0090729 biolink:NamedThing toxin activity Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom. got7fsn_ti toxin receptor binding tb 2016-12-19T15:23:27Z GO:0050827 Wikipedia:Toxin molecular_function owl:Class GO:0003674 biolink:NamedThing molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. got7fsn_ti molecular function Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. GO:0005554 molecular_function owl:Class GO:0007089 biolink:NamedThing traversing start control point of mitotic cell cycle A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity. got7fsn_ti GO:0000081 biological_process owl:Class GO:1900087 biolink:NamedThing positive regulation of G1/S transition of mitotic cell cycle Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. got7fsn_ti activation of G1/S transition of mitotic cell cycle|up regulation of G1/S transition of mitotic cell cycle|up-regulation of G1/S transition of mitotic cell cycle|upregulation of G1/S transition of mitotic cell cycle rph 2012-02-08T12:24:39Z biological_process owl:Class GO:0035116 biolink:NamedThing embryonic hindlimb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. got7fsn_ti biological_process owl:Class GO:0030326 biolink:NamedThing embryonic limb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. got7fsn_ti biological_process owl:Class GO:0048462 biolink:NamedThing carpel formation The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti GO:0048431 biological_process owl:Class GO:0048449 biolink:NamedThing floral organ formation The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti GO:0048436 biological_process owl:Class GO:0003105 biolink:NamedThing negative regulation of glomerular filtration Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. got7fsn_ti biological_process owl:Class GO:0051241 biolink:NamedThing negative regulation of multicellular organismal process Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. got7fsn_ti down regulation of multicellular organismal process|down-regulation of multicellular organismal process|downregulation of multicellular organismal process|inhibition of multicellular organismal process biological_process owl:Class GO:0061760 biolink:NamedThing antifungal innate immune response An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. got7fsn_ti dph 2016-03-07T08:53:08Z biological_process owl:Class GO:0045087 biolink:NamedThing innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. got7fsn_ti nonspecific immune response|innate immunity GO:0002226 Wikipedia:Innate_immune_system biological_process owl:Class GO:0019815 biolink:NamedThing B cell receptor complex An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti B lymphocyte receptor complex|immunoglobulin complex, membrane bound|BCR complex|B-lymphocyte receptor complex|antibody|B-cell receptor complex|B cell receptor accessory molecule complex Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. GO:0042570 cellular_component owl:Class GO:0043235 biolink:NamedThing receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. got7fsn_ti cellular_component owl:Class GO:0004689 biolink:NamedThing phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. got7fsn_ti dephosphophosphorylase kinase activity|phosphorylase kinase (phosphorylating) activity|phosphorylase B kinase activity|phosphorylase kinase, intrinsic catalyst activity|glycogen phosphorylase kinase activity|PHK|STK17|ATP:phosphorylase-b phosphotransferase activity GO:0008606 Reactome:R-HSA-453337|Reactome:R-HSA-71541|Reactome:R-HSA-71588|MetaCyc:2.7.11.19-RXN|EC:2.7.11.19 molecular_function owl:Class GO:0004683 biolink:NamedThing calmodulin-dependent protein kinase activity Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. got7fsn_ti multifunctional calcium- and calmodulin-regulated protein kinase activity|calcium- and calmodulin-dependent protein kinase activity|caldesmon kinase (phosphorylating) activity|CaMKKbeta|calcium/calmodulin-dependent protein kinase type II activity|calmodulin regulated protein kinase activity|CaM kinase II activity|calcium/calmodulin-dependent protein kinase activity|calmodulin-dependent protein kinase I activity|CaMKI|ATP:caldesmon O-phosphotransferase activity|multifunctional calcium/calmodulin regulated protein kinase activity|STK20|Ca2+/calmodulin-dependent protein kinase activity|Ca2+/calmodulin-dependent protein kinase IV activity|CAM PKII|CaMKKalpha|CaM-regulated serine/threonine kinase activity|CaM kinase activity|Ca2+/calmodulin-dependent protein kinase kinase beta activity|Ca2+/calmodulin-dependent protein kinase kinase activity|Ca2+/calmodulin-dependent protein kinase 1 activity|CaMKIV|CaMKII|calmodulin-dependent kinase II activity|Ca2+/CaM-dependent kinase activity|Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity|microtubule-associated protein 2 kinase activity|Ca2+/calmodulin-dependent protein kinase II activity|ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity These reactions require the presence of calcium-bound calmodulin. GO:0004685|GO:0004688|GO:0004684 Reactome:R-HSA-9619355|Reactome:R-HSA-9617583|Reactome:R-HSA-9619478|Reactome:R-HSA-9618750|Reactome:R-HSA-111912|Reactome:R-HSA-9619783|Reactome:R-HSA-111915|Reactome:R-HSA-9619367|MetaCyc:2.7.11.17-RXN|Reactome:R-HSA-416320|EC:2.7.11.17|Reactome:R-HSA-442749|Reactome:R-HSA-9006992|Reactome:R-HSA-9619125 molecular_function owl:Class GO:0030050 biolink:NamedThing vesicle transport along actin filament Movement of a vesicle along an actin filament, mediated by motor proteins. got7fsn_ti biological_process owl:Class GO:0030048 biolink:NamedThing actin filament-based movement Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. got7fsn_ti biological_process owl:Class GO:0097506 biolink:NamedThing deaminated base DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated bases. got7fsn_ti DNA glycosylase activity acting on deaminated bases|deaminated base DNA glycosylase activity pr 2013-09-26T16:00:40Z molecular_function owl:Class GO:0019104 biolink:NamedThing DNA N-glycosylase activity Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. got7fsn_ti endonuclease VIII activity|DNA glycosylase activity GO:0008578 Reactome:R-HSA-9629149|Reactome:R-HSA-9636008|Reactome:R-HSA-110250|Reactome:R-HSA-110231|Reactome:R-HSA-5220959|Reactome:R-HSA-110234|Reactome:R-HSA-5649673|Reactome:R-HSA-110246|Reactome:R-HSA-9629497|Reactome:R-HSA-9635996|Reactome:R-HSA-110219|Reactome:R-HSA-110218|Reactome:R-HSA-110251|Reactome:R-HSA-9629483|Reactome:R-HSA-9629492|Reactome:R-HSA-110232|Reactome:R-HSA-5649664|Reactome:R-HSA-5649658|Reactome:R-HSA-5221061|Reactome:R-HSA-9629499|Reactome:R-HSA-9629470|Reactome:R-HSA-110248|Reactome:R-HSA-5649681|Reactome:R-HSA-9629216 molecular_function owl:Class GO:0061269 biolink:NamedThing mesonephric glomerular mesangial cell proliferation involved in mesonephros development The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population. got7fsn_ti dph 2010-08-30T03:20:57Z biological_process owl:Class GO:0061209 biolink:NamedThing cell proliferation involved in mesonephros development The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros. got7fsn_ti dph 2010-08-17T03:22:46Z biological_process owl:Class GO:0047798 biolink:NamedThing cyclomaltodextrinase activity Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin. got7fsn_ti cyclohexaglucanase activity|cyclodextrinase activity|cyclomaltodextrin dextrin-hydrolase (decyclizing)|cycloheptaglucanase activity MetaCyc:CYCLOMALTODEXTRINASE-RXN|RHEA:23980|EC:3.2.1.54 molecular_function owl:Class GO:0034358 biolink:NamedThing plasma lipoprotein particle A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph. got7fsn_ti cellular_component owl:Class GO:1990777 biolink:NamedThing lipoprotein particle A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph. got7fsn_ti pr 2015-06-18T08:42:53Z cellular_component owl:Class GO:1990416 biolink:NamedThing cellular response to brain-derived neurotrophic factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus. got7fsn_ti cellular response to BDNF stimulus sl 2014-07-11T17:55:59Z biological_process owl:Class GO:1990090 biolink:NamedThing cellular response to nerve growth factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. got7fsn_ti cellular response to NGF sl 2013-05-06T17:13:36Z biological_process owl:Class GO:0006346 biolink:NamedThing DNA methylation-dependent heterochromatin assembly Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. got7fsn_ti methylation-dependent heterochromatic silencing|methylation-dependent chromatin silencing https://github.com/geneontology/go-ontology/issues/22047 biological_process owl:Class GO:0031507 biolink:NamedThing heterochromatin assembly An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. got7fsn_ti establishment of heterochromatin architecture|chromatin-mediated silencing|establishment of heterochromatin architecture involved in chromatin silencing at pericentric region|establishment of chromatin silencing|establishment of heterochromatic silencing|heterochromatin formation|heterochromatin formation involved in chromatin silencing|chromatin silencing|TGS|heterochromatic silencing|heterochromatin assembly involved in chromatin silencing|heterochromatin assembly involved in chromatin silencing at pericentric region|transcriptional gene silencing|establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region|heterochromatin maintenance|heterochromatin formation involved in chromatin silencing at centromere outer repeat region|heterochromatin assembly involved in chromatin silencing at centromere outer repeat region|heterochromatin formation involved in chromatin silencing at pericentric region https://github.com/geneontology/go-ontology/issues/18954|https://github.com/geneontology/go-ontology/issues/22030|https://github.com/geneontology/go-ontology/issues/19112 GO:0006343|GO:1904497|GO:0016440|GO:0070869|GO:0006342 biological_process owl:Class GO:0046666 biolink:NamedThing retinal cell programmed cell death Programmed cell death that occurs in the developing retina. got7fsn_ti retina programmed cell death|retina cell programmed cell death|retinal programmed cell death|programmed cell death, retinal cells|programmed cell death, retina cells biological_process owl:Class GO:0098834 biolink:NamedThing presynaptic endocytic zone cytoplasmic component The cytoplasmic component of the presynaptic endocytic zone. got7fsn_ti cortex of presynaptic endocytic zone cellular_component owl:Class GO:0099738 biolink:NamedThing cell cortex region The complete extent of cell cortex that underlies some some region of the plasma membrane. got7fsn_ti perimembrane region cellular_component owl:Class GO:0102538 biolink:NamedThing UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-14767 molecular_function owl:Class GO:0016623 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen. got7fsn_ti EC:1.2.3.- molecular_function owl:Class GO:0016903 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors EC:1.2.-.- molecular_function owl:Class GO:0075512 biolink:NamedThing clathrin-dependent endocytosis of virus by host cell Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus. got7fsn_ti viral entry into host cell via clathrin-mediated endocytosis|viral entry into host cell via clathrin-mediated endocytosis followed by endosome lysis|viral penetration via clathrin-mediated endocytosis|clathrin-mediated endocytosis of virus by host cell jl 2011-07-27T02:08:54Z GO:0075516 VZ:957 biological_process owl:Class GO:0072583 biolink:NamedThing clathrin-dependent endocytosis An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. got7fsn_ti clathrin-mediated endocytosis|clathrin-dependent endocytosis|clathrin coated pit-dependent endocytosis|CME mah 2011-02-08T03:59:18Z biological_process owl:Class GO:0060455 biolink:NamedThing negative regulation of gastric acid secretion Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. got7fsn_ti biological_process owl:Class GO:0060453 biolink:NamedThing regulation of gastric acid secretion Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. got7fsn_ti biological_process owl:Class GO:0021592 biolink:NamedThing fourth ventricle development The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space. got7fsn_ti biological_process owl:Class GO:0044108 biolink:NamedThing cellular alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell. got7fsn_ti jl 2009-07-15T01:38:25Z biological_process owl:Class GO:0044249 biolink:NamedThing cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. got7fsn_ti cellular formation|cellular synthesis|cellular biosynthesis|cellular anabolism biological_process owl:Class GO:0048936 biolink:NamedThing peripheral nervous system neuron axonogenesis Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells. got7fsn_ti biological_process owl:Class GO:0042465 biolink:NamedThing kinesis The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus. got7fsn_ti Wikipedia:Kinesis biological_process owl:Class GO:0009605 biolink:NamedThing response to external stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. got7fsn_ti response to environmental stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0048639 biolink:NamedThing positive regulation of developmental growth Any process that activates, maintains or increases the rate of developmental growth. got7fsn_ti up-regulation of developmental growth|activation of developmental growth|upregulation of developmental growth|stimulation of developmental growth|up regulation of developmental growth biological_process owl:Class GO:0045927 biolink:NamedThing positive regulation of growth Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. got7fsn_ti stimulation of growth|upregulation of growth|up-regulation of growth|up regulation of growth|activation of growth biological_process owl:Class GO:0045210 biolink:NamedThing FasL biosynthetic process The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines. got7fsn_ti FASLG biosynthetic process|FasL formation|CD95L biosynthetic process|APT1LG1 biosynthetic process|CD178 biosynthetic process|FasL synthesis|fas ligand biosynthetic process|CD95L biosynthesis|FasL anabolism|Fas-L biosynthetic process|FasL biosynthesis biological_process owl:Class GO:0009101 biolink:NamedThing glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. got7fsn_ti glycoprotein biosynthesis|glycoprotein anabolism|glycoprotein synthesis|glycoprotein formation biological_process owl:Class GO:0014010 biolink:NamedThing Schwann cell proliferation The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. got7fsn_ti biological_process owl:Class GO:0014009 biolink:NamedThing glial cell proliferation The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. got7fsn_ti glia proliferation biological_process owl:Class GO:0050742 biolink:NamedThing protein-FMN linkage via S-(4a-FMN)-L-cysteine The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine. got7fsn_ti RESID:AA0351 biological_process owl:Class GO:0018309 biolink:NamedThing protein-FMN linkage The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN). got7fsn_ti biological_process owl:Class GO:0047224 biolink:NamedThing acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP. got7fsn_ti uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity|core 3-beta-GlcNAc-transferase activity|mucin core 3 beta3-GlcNAc-transferase activity|UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity|O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity|core 3beta-GlcNAc-transferase activity EC:2.4.1.147|RHEA:14252|MetaCyc:2.4.1.147-RXN molecular_function owl:Class GO:0008375 biolink:NamedThing acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. got7fsn_ti GlcNAc transferase activity Reactome:R-HSA-9694656|Reactome:R-HSA-9683648|Reactome:R-HSA-5694487|Reactome:R-HSA-8879117 molecular_function owl:Class GO:0061241 biolink:NamedThing mesonephric nephron epithelium development The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros. got7fsn_ti dph 2010-08-19T03:11:59Z biological_process owl:Class GO:0072009 biolink:NamedThing nephron epithelium development The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. got7fsn_ti mah 2010-01-25T02:01:39Z biological_process owl:Class GO:0047041 biolink:NamedThing (S)-carnitine 3-dehydrogenase activity Catalysis of the reaction: (S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH. got7fsn_ti (S)-carnitine:NAD+ oxidoreductase activity|D-carnitine dehydrogenase activity KEGG_REACTION:R01921|RHEA:11556|EC:1.1.1.254|MetaCyc:1.1.1.254-RXN molecular_function owl:Class GO:0035186 biolink:NamedThing syncytial blastoderm mitotic cell cycle Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively. got7fsn_ti biological_process owl:Class GO:0033301 biolink:NamedThing cell cycle comprising mitosis without cytokinesis A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N). got7fsn_ti Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers. biological_process owl:Class GO:0008380 biolink:NamedThing RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. got7fsn_ti pre-mRNA splicing factor activity GO:0006395 Wikipedia:RNA_splicing biological_process owl:Class GO:0006396 biolink:NamedThing RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. got7fsn_ti GO:0006394 Wikipedia:Post-transcriptional_modification biological_process owl:Class GO:0099018 biolink:NamedThing restriction-modification system evasion by virus Any process, either active or passive, by which a virus evades the DNA restriction modification system of its host. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction. got7fsn_ti VZ:3966 biological_process owl:Class GO:0019049 biolink:NamedThing mitigation of host defenses by virus A process by which a virus avoids or tolerates the effects of its host organism's defenses. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti evasion of host defenses by virus|viral host defence evasion|evasion or tolerance of host defenses by virus|viral host defense evasion biological_process owl:Class GO:0090492 biolink:NamedThing N,N-Dihydroxy-L-tryptophan decarboxylase activity Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O. got7fsn_ti tb 2012-10-16T16:32:30Z molecular_function owl:Class GO:0016831 biolink:NamedThing carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. got7fsn_ti decarboxylase activity EC:4.1.1.-|Reactome:R-HSA-6814165|Reactome:R-HSA-6787757|Reactome:R-HSA-71223 molecular_function owl:Class GO:0047437 biolink:NamedThing 4-oxalocrotonate decarboxylase activity Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate. got7fsn_ti 4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)|4-oxalocrotonate carboxy-lyase activity MetaCyc:4.1.1.77-RXN|UM-BBD_reactionID:r1435|RHEA:24260|EC:4.1.1.77 molecular_function owl:Class GO:0002696 biolink:NamedThing positive regulation of leukocyte activation Any process that activates or increases the frequency, rate, or extent of leukocyte activation. got7fsn_ti positive regulation of leucocyte activation|upregulation of leukocyte activation|stimulation of leukocyte activation|activation of leukocyte activation|up regulation of leukocyte activation|up-regulation of leukocyte activation|positive regulation of immune cell activation biological_process owl:Class GO:0050867 biolink:NamedThing positive regulation of cell activation Any process that activates or increases the frequency, rate or extent of activation. got7fsn_ti activation of cell activation|stimulation of cell activation|up regulation of cell activation|upregulation of cell activation|up-regulation of cell activation biological_process owl:Class GO:0021821 biolink:NamedThing negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. got7fsn_ti down regulation of cell-glial cell adhesion involved in cerebral cortex lamination|down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination|downregulation of cell-glial cell adhesion involved in cerebral cortex lamination|inhibition of cell-glial cell adhesion involved in cerebral cortex lamination biological_process owl:Class GO:0022408 biolink:NamedThing negative regulation of cell-cell adhesion Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. got7fsn_ti down-regulation of cell-cell adhesion|downregulation of cell-cell adhesion|down regulation of cell-cell adhesion|inhibition of cell-cell adhesion biological_process owl:Class GO:0022894 biolink:NamedThing Intermediate conductance calcium-activated potassium channel activity Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. got7fsn_ti IK KCa channels|IK calcium-activated potassium channel activity|intermdiate conductance KCa channels molecular_function owl:Class GO:0015269 biolink:NamedThing calcium-activated potassium channel activity Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. got7fsn_ti molecular_function owl:Class GO:0034524 biolink:NamedThing 2-hydroxyisophthalate decarboxylase activity Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2. got7fsn_ti UM-BBD_reactionID:r0776 molecular_function owl:Class GO:0007008 biolink:NamedThing outer mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane. got7fsn_ti outer mitochondrial membrane organisation|outer mitochondrial membrane organization and biogenesis See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. biological_process owl:Class GO:0007006 biolink:NamedThing mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. got7fsn_ti mitochondrial membrane organisation|mitochondrial membrane organization and biogenesis biological_process owl:Class GO:0044648 biolink:NamedThing histone H3-K4 dimethylation The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone. got7fsn_ti jl 2012-07-11T01:27:33Z biological_process owl:Class GO:0051568 biolink:NamedThing histone H3-K4 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. got7fsn_ti histone H3 K4 methylation|histone H3K4me|histone lysine H3 K4 methylation biological_process owl:Class GO:0035678 biolink:NamedThing neuromast hair cell morphogenesis The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. got7fsn_ti bf 2011-02-14T11:06:15Z biological_process owl:Class GO:0048667 biolink:NamedThing cell morphogenesis involved in neuron differentiation The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. got7fsn_ti neuron morphogenesis involved in differentiation biological_process owl:Class GO:0075113 biolink:NamedThing induction by symbiont of host transmembrane receptor-mediated signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host transmembrane receptor-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075082". biological_process owl:Class GO:0075110 biolink:NamedThing induction by symbiont of host receptor-mediated signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host receptor-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont receptor-mediated signal transduction ; GO:0075079". biological_process owl:Class GO:1900611 biolink:NamedThing F-9775A biosynthetic process The chemical reactions and pathways resulting in the formation of F-9775A. got7fsn_ti F-9775A anabolism|F-9775A synthesis|F-9775A biosynthesis|F-9775A formation di 2012-05-15T07:02:56Z biological_process owl:Class GO:0009719 biolink:NamedThing response to endogenous stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0050896 biolink:NamedThing response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. got7fsn_ti physiological response to stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0051869 biological_process owl:Class GO:0098505 biolink:NamedThing G-rich strand telomeric DNA binding Binding to G-rich, single-stranded, telomere-associated DNA. got7fsn_ti dos 2013-09-23T13:16:24Z molecular_function owl:Class GO:0043047 biolink:NamedThing single-stranded telomeric DNA binding Binding to single-stranded telomere-associated DNA. got7fsn_ti telomeric ssDNA binding molecular_function owl:Class GO:0035284 biolink:NamedThing brain segmentation Division of the brain into a series of semi-repetitive parts or segments. got7fsn_ti biological_process owl:Class GO:0035282 biolink:NamedThing segmentation The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. got7fsn_ti Wikipedia:Segmentation_(biology) biological_process owl:Class GO:0090647 biolink:NamedThing modulation of age-related behavioral decline Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory. got7fsn_ti tb 2015-06-15T12:45:44Z biological_process owl:Class GO:0002170 biolink:NamedThing high-affinity IgA receptor activity Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti high affinity IgA receptor activity hjd 2010-05-06T05:00:11Z molecular_function owl:Class GO:0019766 biolink:NamedThing IgA receptor activity Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class GO:0048040 biolink:NamedThing UDP-glucuronate decarboxylase activity Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose. got7fsn_ti UDPglucuronate decarboxylase activity|UDP-glucuronic acid decarboxylase activity|uridine-diphosphoglucuronate decarboxylase activity|UDP-D-glucuronate carboxy-lyase activity|UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming) KEGG_REACTION:R01384|MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN|RHEA:23916|EC:4.1.1.35 molecular_function owl:Class GO:0101030 biolink:NamedThing tRNA-guanine transglycosylation The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. got7fsn_ti biological_process owl:Class GO:0018631 biolink:NamedThing phenylacetate hydroxylase activity Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate. got7fsn_ti UM-BBD_reactionID:r0036|EC:1.14.13.- molecular_function owl:Class GO:0031269 biolink:NamedThing pseudopodium assembly The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane. got7fsn_ti pseudopodium formation|pseudopodium extension biological_process owl:Class GO:0031268 biolink:NamedThing pseudopodium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. got7fsn_ti pseudopodium organisation|pseudopodium organization and biogenesis biological_process owl:Class GO:0038033 biolink:NamedThing positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis. got7fsn_ti VEGF-mediated chemotactic endothelial cell migration|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway|positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway|VEGF-VEGFR-induced endothelial cell chemotaxis|vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis bf 2011-09-19T02:36:37Z biological_process owl:Class GO:0048010 biolink:NamedThing vascular endothelial growth factor receptor signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGF receptor signaling pathway|VEGFR signaling pathway|VEGF receptor signalling pathway In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'. biological_process owl:Class GO:0140405 biolink:NamedThing spindle pole body-led chromosome movement during mitotic interphase A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18373|https://github.com/geneontology/go-ontology/issues/19149 pg 2019-12-10T09:13:47Z biological_process owl:Class GO:0051303 biolink:NamedThing establishment of chromosome localization The directed movement of a chromosome to a specific location. got7fsn_ti chromosome positioning|establishment of chromosome localisation biological_process owl:Class GO:0102408 biolink:NamedThing sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate <=> coenzyme A + sn-2-C16:0-DCA-LPA. got7fsn_ti MetaCyc:RXN-13735 molecular_function owl:Class GO:0018838 biolink:NamedThing mandelate racemase activity Catalysis of the reaction: (S)-mandelate = (R)-mandelate. got7fsn_ti RHEA:13945|EC:5.1.2.2|MetaCyc:MANDELATE-RACEMASE-RXN|UM-BBD_reactionID:r0091 molecular_function owl:Class GO:0016856 biolink:NamedThing racemase and epimerase activity, acting on hydroxy acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule. got7fsn_ti EC:5.1.2.- molecular_function owl:Class GO:0018159 biolink:NamedThing peptidyl-methionine oxidation The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone. got7fsn_ti RESID:AA0251 biological_process owl:Class GO:0018206 biolink:NamedThing peptidyl-methionine modification The modification of peptidyl-methionine. got7fsn_ti biological_process owl:Class GO:0007287 biolink:NamedThing Nebenkern assembly Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern. got7fsn_ti Nebenkern formation|Nebenkern assembly See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'. biological_process owl:Class GO:0003006 biolink:NamedThing developmental process involved in reproduction A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. got7fsn_ti puberty|reproductive developmental process biological_process owl:Class GO:0034533 biolink:NamedThing 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate. got7fsn_ti UM-BBD_reactionID:r0764 molecular_function owl:Class GO:0016701 biolink:NamedThing oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. got7fsn_ti oxygenase|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous EC:1.13.-.- molecular_function owl:Class GO:0031173 biolink:NamedThing otolith mineralization completed early in development The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear. got7fsn_ti otoconia mineralization|otoconium mineralization biological_process owl:Class GO:0045299 biolink:NamedThing otolith mineralization The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear. got7fsn_ti biological_process owl:Class GO:0061362 biolink:NamedThing negative regulation of maintenance of bipolar cell polarity regulating cell shape Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape. got7fsn_ti dph 2010-10-13T09:03:42Z biological_process owl:Class GO:2000115 biolink:NamedThing regulation of maintenance of bipolar cell polarity regulating cell shape Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape. got7fsn_ti dph 2010-09-21T06:33:26Z biological_process owl:Class GO:0052891 biolink:NamedThing aliphatic (S)-hydroxynitrile lyase activity Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide. got7fsn_ti oxynitrilase activity|(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity|(S)-hydroxynitrile lyase activity|(S)-cyanohydrin producing hydroxynitrile lyase activity|(S)-oxynitrilase activity|(S)-selective hydroxynitrile lyase activity|hydroxynitrile lyase activity EC:4.1.2.47|MetaCyc:RXN-11731 molecular_function owl:Class GO:0032919 biolink:NamedThing spermine acetylation The modification of spermine by addition of acetyl groups. got7fsn_ti biological_process owl:Class GO:0032917 biolink:NamedThing polyamine acetylation The modification of polyamines by addition of acetyl groups. got7fsn_ti biological_process owl:Class GO:0070227 biolink:NamedThing lymphocyte apoptotic process Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. got7fsn_ti lymphocyte apoptosis Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). biological_process owl:Class GO:0071887 biolink:NamedThing leukocyte apoptotic process Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. got7fsn_ti leukocyte apoptosis Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). mah 2010-09-14T12:44:09Z biological_process owl:Class GO:0033455 biolink:NamedThing GCA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GCA codon. got7fsn_ti alanine tRNA Note that in the standard genetic code, GCA codes for alanine. molecular_function owl:Class GO:0030533 biolink:NamedThing triplet codon-amino acid adaptor activity The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis. got7fsn_ti tRNA|transfer RNA Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. molecular_function owl:Class GO:0050954 biolink:NamedThing sensory perception of mechanical stimulus The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti mechanosensory perception|perception of mechanical stimulus|chemi-mechanical coupling biological_process owl:Class GO:0007600 biolink:NamedThing sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti Wikipedia:Perception biological_process owl:Class GO:0001892 biolink:NamedThing embryonic placenta development The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. got7fsn_ti fetal placenta development biological_process owl:Class GO:0048568 biolink:NamedThing embryonic organ development Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti embryonic organogenesis biological_process owl:Class GO:0009639 biolink:NamedThing response to red or far red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti biological_process owl:Class GO:0009416 biolink:NamedThing response to light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. got7fsn_ti biological_process owl:Class GO:0018573 biolink:NamedThing 2-aminophenol 1,6-dioxygenase activity Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0305 molecular_function owl:Class GO:0018596 biolink:NamedThing dimethylsilanediol hydroxylase activity Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol. got7fsn_ti DMSD hydroxylase activity UM-BBD_reactionID:r0637 molecular_function owl:Class GO:0070467 biolink:NamedThing RC-1 DNA recombination complex A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA. got7fsn_ti RC-1 complex (recombination complex 1)|DNA recombination complex RC-1 cellular_component owl:Class GO:0048071 biolink:NamedThing sex-specific pigmentation Establishment of a pattern of pigment in one sex that is not observed in the other sex. got7fsn_ti biological_process owl:Class GO:0018477 biolink:NamedThing benzaldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+. got7fsn_ti benzaldehyde:NADP+ oxidoreductase|NADP-linked benzaldehyde dehydrogenase UM-BBD_enzymeID:e0079|MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN|EC:1.2.1.7|RHEA:21660 molecular_function owl:Class GO:0033721 biolink:NamedThing aldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+. got7fsn_ti aldehyde:NADP+ oxidoreductase activity|NADP-acetaldehyde dehydrogenase activity|NADP-dependent aldehyde dehydrogenase activity RHEA:11888|EC:1.2.1.4|MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN molecular_function owl:Class GO:0008481 biolink:NamedThing sphinganine kinase activity Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. got7fsn_ti sphingosine kinase (phosphorylating)|sphingosine kinase activity|ATP:sphinganine 1-phosphotransferase activity|dihydrosphingosine kinase activity|dihydrosphingosine kinase (phosphorylating) GO:0001728 MetaCyc:SPHINGANINE-KINASE-RXN|RHEA:15465|Reactome:R-HSA-428214|EC:2.7.1.91 molecular_function owl:Class GO:0001727 biolink:NamedThing lipid kinase activity Catalysis of the phosphorylation of a simple or complex lipid. got7fsn_ti molecular_function owl:Class GO:0019253 biolink:NamedThing reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. got7fsn_ti Calvin cycle|C3 photosynthesis See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. MetaCyc:CALVIN-PWY biological_process owl:Class GO:0019685 biolink:NamedThing photosynthesis, dark reaction A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions. got7fsn_ti biological_process owl:Class GO:0031603 biolink:NamedThing cytosolic proteasome core complex The core complex of a proteasome located in the cytosol of a cell. got7fsn_ti cellular_component owl:Class GO:0005839 biolink:NamedThing proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. got7fsn_ti 20S proteasome|20S core complex|macropain|PA28gamma-20S proteasome GO:0000503 cellular_component owl:Class GO:0052344 biolink:NamedThing positive regulation by symbiont of host phytoalexin production Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction|stimulation by symbiont of host phytoalexin production|upregulation by symbiont of host phytoalexin production|up-regulation by symbiont of host phytoalexin production|activation by symbiont of host phytoalexin production|up regulation by symbiont of host phytoalexin production GO:0052329 biological_process owl:Class GO:0052559 biolink:NamedThing induction by symbiont of host immune response Any process in which a symbiont activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti activation by symbiont of host immune response|upregulation by symbiont of host immune response|positive regulation by symbiont of host immune response|up-regulation by symbiont of host immune response|positive regulation by organism of immune response of other organism involved in symbiotic interaction|induction by organism of immune response of other organism involved in symbiotic interaction|up regulation by symbiont of host immune response|stimulation by symbiont of host immune response GO:0052556|GO:0052558|GO:0052555 biological_process owl:Class GO:0043870 biolink:NamedThing N-acetyl-gamma-aminoadipyl-phosphate reductase activity Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH. got7fsn_ti AGPR|ArgC|NAGSA dehydrogenase activity|LysY|N-acetyl-aminoadipate semialdehyde dehydrogenase activity|N-acetyl-alpha-glutamyl-phosphate reductase activity This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway. RHEA:41948|MetaCyc:RXN-5183 molecular_function owl:Class GO:0021832 biolink:NamedThing cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration. got7fsn_ti biological_process owl:Class GO:0098742 biolink:NamedThing cell-cell adhesion via plasma-membrane adhesion molecules The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. got7fsn_ti biological_process owl:Class GO:0036312 biolink:NamedThing phosphatidylinositol 3-kinase regulatory subunit binding Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. got7fsn_ti PI3K regulatory subunit binding|p85 binding bf 2012-08-16T10:58:45Z molecular_function owl:Class GO:0043548 biolink:NamedThing phosphatidylinositol 3-kinase binding Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. got7fsn_ti PI3K binding|phosphoinositide 3-kinase binding molecular_function owl:Class GO:0060085 biolink:NamedThing smooth muscle relaxation of the bladder outlet A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body. got7fsn_ti synaptic transmission involved in urination biological_process owl:Class GO:0061206 biolink:NamedThing mesonephros morphogenesis The process in which the anatomical structures of the mesonephros are generated and organized. got7fsn_ti Wolffian body morphogenesis dph 2010-08-17T03:11:10Z biological_process owl:Class GO:0060993 biolink:NamedThing kidney morphogenesis Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti dph 2010-01-19T08:16:55Z biological_process owl:Class GO:0030186 biolink:NamedThing melatonin metabolic process The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine). got7fsn_ti melatonin metabolism biological_process owl:Class GO:0042430 biolink:NamedThing indole-containing compound metabolic process The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. got7fsn_ti indole derivative metabolic process|indole derivative metabolism|indole and derivative metabolism|ketole metabolism|indole-containing compound metabolism|ketole metabolic process|indole and derivative metabolic process GO:0042434 biological_process owl:Class GO:0033428 biolink:NamedThing CAG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CAG codon. got7fsn_ti glutamine tRNA Note that in the standard genetic code, CAG codes for glutamine. molecular_function owl:Class GO:0044593 biolink:NamedThing iron-sulfur-molybdenum cofactor assembly The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase. got7fsn_ti iron molybdenum cofactor assembly|iron molybdenum cofactor biosynthesis|FeMoco biosynthetic process|iron molybdenum cofactor biosynthetic process|FeMoco assembly jl 2012-04-26T04:01:53Z biological_process owl:Class GO:0016226 biolink:NamedThing iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. got7fsn_ti iron-sulphur cluster assembly|iron-sulfur cluster biosynthesis biological_process owl:Class GO:0070254 biolink:NamedThing mucus secretion The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. got7fsn_ti mucus production biological_process owl:Class GO:0032941 biolink:NamedThing secretion by tissue The controlled release of a substance by a tissue. got7fsn_ti tissue secretion|expulsion of gland contents biological_process owl:Class GO:0098966 biolink:NamedThing perisynaptic extracellular matrix The portion of the extracellular matrix that lies within the perisynaptic space. got7fsn_ti extrasynaptic extracellular matrix|perisynaptic ECM cellular_component owl:Class GO:0062023 biolink:NamedThing collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. got7fsn_ti dph 2018-04-13T12:47:21Z cellular_component owl:Class GO:0016746 biolink:NamedThing acyltransferase activity Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring acyl groups|acyltransferase activity https://github.com/geneontology/go-ontology/issues/20486 GO:0008415 Reactome:R-HSA-193491|EC:2.3.-.-|Reactome:R-HSA-159431|Reactome:R-HSA-192312|Reactome:R-HSA-8858298|Reactome:R-HSA-6792572 molecular_function owl:Class GO:0018278 biolink:NamedThing N-terminal peptidyl-threonine deamination The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid. got7fsn_ti RESID:AA0129 biological_process owl:Class GO:0018058 biolink:NamedThing N-terminal protein amino acid deamination, from amino carbon The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol. got7fsn_ti RESID:AA0127|RESID:AA0129|RESID:AA0128 biological_process owl:Class GO:0099137 biolink:NamedThing altruistic, chimeric, non-reproductive fruiting body development Development of a chimeric, non-reproductive fruiting body in which cells of all genotypes have an equal chance of becoming a spore cell. got7fsn_ti fully co-operative, chimeric, non-reproductive fruiting body development biological_process owl:Class GO:0099136 biolink:NamedThing chimeric non-reproductive fruiting body development Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes. got7fsn_ti biological_process owl:Class GO:0071720 biolink:NamedThing sodium-independent prostaglandin transport The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti mah 2010-03-10T03:09:10Z biological_process owl:Class GO:0071718 biolink:NamedThing sodium-independent icosanoid transport The directed, sodium-independent, movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. got7fsn_ti sodium-independent eicosanoid transport mah 2010-03-10T03:05:13Z biological_process owl:Class GO:0071743 biolink:NamedThing IgE immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti IgE antibody Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class GO:0042571 biolink:NamedThing immunoglobulin complex, circulating An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. got7fsn_ti antibody Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Wikipedia:Antibody cellular_component owl:Class GO:0052922 biolink:NamedThing hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate. got7fsn_ti hexaprenyl pyrophosphate synthetase activity|hexaprenyl diphosphate synthase activity|(all-trans)-hexaprenyl-diphosphate synthase activity|(all-E) hexaprenyl diphosphate synthase activity KEGG_REACTION:R09246|MetaCyc:RXN-11485|RHEA:27555|EC:2.5.1.82 molecular_function owl:Class GO:0004659 biolink:NamedThing prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). got7fsn_ti MetaCyc:GPPSYN-RXN|Reactome:R-HSA-6806674 molecular_function owl:Class GO:1902549 biolink:NamedThing protein localization to Mei2 nuclear dot A process in which a protein is transported to, or maintained in, a location within a Mei2 nuclear dot. got7fsn_ti protein localisation to Mei2 nuclear dot|protein localization in Mei2 nuclear dot|protein localization to Mei2 dot|protein localisation in Mei2 nuclear dot mah 2013-12-04T16:17:06Z biological_process owl:Class GO:0034613 biolink:NamedThing cellular protein localization Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. got7fsn_ti cellular protein localisation|channel localizer activity GO:0016249 biological_process owl:Class GO:0008406 biolink:NamedThing gonad development The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. got7fsn_ti gonadogenesis biological_process owl:Class GO:0048608 biolink:NamedThing reproductive structure development The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. got7fsn_ti biological_process owl:Class GO:0004129 biolink:NamedThing cytochrome-c oxidase activity Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. got7fsn_ti ba3-type cytochrome c oxidase|cbb3-type cytochrome c oxidase|cytochrome aa3 activity|cytochrome c oxidase activity|Warburg's respiratory enzyme activity|complex IV (mitochondrial electron transport) activity|caa3-type cytochrome c oxidase|cytochrome oxidase activity|aa3-type cytochrome c oxidase|indophenolase|indophenol oxidase|cytochrome a3 activity https://github.com/geneontology/go-ontology/issues/21275|https://github.com/geneontology/go-ontology/issues/20924 The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. RHEA:11436|MetaCyc:CYTOCHROME-C-OXIDASE-RXN|Reactome:R-HSA-163214|EC:7.1.1.9 molecular_function owl:Class GO:0015453 biolink:NamedThing oxidoreduction-driven active transmembrane transporter activity Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. got7fsn_ti oxidoreduction-driven transporter TC:3.D molecular_function owl:Class GO:0017178 biolink:NamedThing diphthine-ammonia ligase activity Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate. got7fsn_ti diphthamide synthetase activity|diphthine:ammonia ligase (ADP-forming)|diphthamide synthase activity RHEA:19753|KEGG_REACTION:R03613|Reactome:R-HSA-5358475|EC:6.3.1.14|MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN molecular_function owl:Class GO:0016880 biolink:NamedThing acid-ammonia (or amide) ligase activity Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti amide synthase activity EC:6.3.1.- molecular_function owl:Class GO:1901362 biolink:NamedThing organic cyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic cyclic compound. got7fsn_ti organic cyclic compound anabolism|organic cyclic compound biosynthesis|organic cyclic compound formation|organic cyclic compound synthesis bf 2012-09-14T09:05:22Z biological_process owl:Class GO:1901576 biolink:NamedThing organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. got7fsn_ti organic molecular entity biosynthetic process|organic substance synthesis|organic substance biosynthesis|organic molecular entity biosynthesis|organic substance formation|organic molecular entity anabolism|organic molecular entity formation|organic molecular entity synthesis|organic substance anabolism pr 2012-11-05T11:04:40Z biological_process owl:Class GO:0090693 biolink:NamedThing plant organ senescence The process that occurs in a plant organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. got7fsn_ti tb 2016-08-24T10:50:29Z biological_process owl:Class GO:0007568 biolink:NamedThing aging A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). got7fsn_ti ageing GO:0016280 Wikipedia:Aging biological_process owl:Class GO:0061634 biolink:NamedThing alpha-D-xyloside xylohydrolase Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose. got7fsn_ti alpha-xylosidase dph 2014-07-28T08:12:39Z EC:3.2.1.177 molecular_function owl:Class GO:0003403 biolink:NamedThing optic vesicle formation The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. got7fsn_ti dph 2009-12-21T01:42:37Z biological_process owl:Class GO:0021508 biolink:NamedThing floor plate formation The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage. got7fsn_ti biological_process owl:Class GO:0033806 biolink:NamedThing fluorothreonine transaldolase activity Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine. got7fsn_ti fluoroacetaldehyde:L-threonine aldehydetransferase activity RHEA:11748|EC:2.2.1.8 molecular_function owl:Class GO:0051139 biolink:NamedThing metal ion:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). got7fsn_ti metal ion:hydrogen antiporter activity Reactome:R-HSA-435171 molecular_function owl:Class GO:0015299 biolink:NamedThing solute:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). got7fsn_ti solute:hydrogen antiporter activity|L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity Reactome:R-HSA-5625574|Reactome:R-HSA-434650|Reactome:R-HSA-597628 molecular_function owl:Class GO:0071907 biolink:NamedThing determination of digestive tract left/right asymmetry Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed. got7fsn_ti determination of gut left/right asymmetry|determination of left/right asymmetry of the digestive tract mah 2010-09-22T10:14:29Z biological_process owl:Class GO:0007368 biolink:NamedThing determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. got7fsn_ti determination of left/right asymmetry biological_process owl:Class GO:0072537 biolink:NamedThing fibroblast activation A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti mah 2011-01-14T04:35:08Z biological_process owl:Class GO:0001775 biolink:NamedThing cell activation A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti biological_process owl:Class GO:0061346 biolink:NamedThing planar cell polarity pathway involved in heart morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart. got7fsn_ti dph 2010-09-30T12:47:24Z biological_process owl:Class GO:0061341 biolink:NamedThing non-canonical Wnt signaling pathway involved in heart development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time. got7fsn_ti non-canonical Wnt receptor signaling pathway involved in heart development|non-canonical Wnt receptor signalling pathway involved in heart development|non-canonical Wnt-activated signaling pathway involved in heart development dph 2010-09-29T11:27:34Z biological_process owl:Class GO:0005170 biolink:NamedThing neurotrophin TRKC receptor binding Binding to a neurotrophin TRKC receptor. got7fsn_ti neurotrophin TRKC receptor ligand molecular_function owl:Class GO:0005167 biolink:NamedThing neurotrophin TRK receptor binding Binding to a neurotrophin TRK receptor. got7fsn_ti neurotrophin TRK receptor ligand molecular_function owl:Class GO:0102790 biolink:NamedThing cyanidin 5,3-O-glycosyltransferase activity Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP. got7fsn_ti MetaCyc:RXN-8006 molecular_function owl:Class GO:1903513 biolink:NamedThing endoplasmic reticulum to cytosol transport The directed movement of substances from endoplasmic reticulum to cytosol. got7fsn_ti ER to cytosol transport rl 2014-10-02T11:24:34Z biological_process owl:Class GO:0046907 biolink:NamedThing intracellular transport The directed movement of substances within a cell. got7fsn_ti single-organism intracellular transport|single organism intracellular transport jl 2013-12-18T14:04:50Z GO:1902582 biological_process owl:Class GO:0102990 biolink:NamedThing 5-n-alk(en)ylresorcinol O-methyltransferase activity Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:26325|MetaCyc:RXN-9619 molecular_function owl:Class GO:0035755 biolink:NamedThing cardiolipin hydrolase activity Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA). got7fsn_ti https://github.com/geneontology/go-ontology/issues/8492|https://github.com/geneontology/go-ontology/issues/21230 bf 2011-03-24T10:14:05Z Reactome:R-HSA-8954398 molecular_function owl:Class GO:0004620 biolink:NamedThing phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid. got7fsn_ti Reactome:R-HSA-6792445|EC:3.1.1.-|Reactome:R-HSA-6786650 molecular_function owl:Class GO:0036017 biolink:NamedThing response to erythropoietin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis. got7fsn_ti bf 2011-10-12T10:11:04Z biological_process owl:Class GO:0006620 biolink:NamedThing posttranslational protein targeting to endoplasmic reticulum membrane The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. got7fsn_ti posttranslational protein targeting to ER membrane|posttranslational endoplasmic reticulum membrane targeting|posttranslational endoplasmic reticulum protein-membrane targeting|SRP-independent endoplasmic reticulum protein-membrane targeting|posttranslational protein endoplasmic reticulum membrane targeting biological_process owl:Class GO:0045047 biolink:NamedThing protein targeting to ER The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. got7fsn_ti protein-endoplasmic reticulum targeting|protein-ER targeting|protein targeting to endoplasmic reticulum biological_process owl:Class GO:0035577 biolink:NamedThing azurophil granule membrane The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. got7fsn_ti primary granule membrane bf 2010-10-05T01:29:10Z cellular_component owl:Class GO:0030667 biolink:NamedThing secretory granule membrane The lipid bilayer surrounding a secretory granule. got7fsn_ti secretory vesicle membrane cellular_component owl:Class GO:0030956 biolink:NamedThing glutamyl-tRNA(Gln) amidotransferase complex A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms. got7fsn_ti AdT|GatFAB|GatCAB Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'. cellular_component owl:Class GO:0140535 biolink:NamedThing intracellular protein-containing complex A protein-containing complex located intracellularly. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19952 pg 2020-10-28T14:40:16Z cellular_component owl:Class GO:0030896 biolink:NamedThing checkpoint clamp complex Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. got7fsn_ti Rad9-Hus1-Rad1 (9-1-1) clamp complex|CCC Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p. cellular_component owl:Class GO:0046888 biolink:NamedThing negative regulation of hormone secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. got7fsn_ti inhibition of hormone secretion|down-regulation of hormone secretion|downregulation of hormone secretion|down regulation of hormone secretion biological_process owl:Class GO:0023057 biolink:NamedThing negative regulation of signaling Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. got7fsn_ti negative regulation of signaling process|negative regulation of signalling process 2010-02-16T09:30:50Z biological_process owl:Class GO:0075289 biolink:NamedThing aplanospore formation The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. got7fsn_ti biological_process owl:Class GO:0034300 biolink:NamedThing sporangiospore formation The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. got7fsn_ti biological_process owl:Class GO:0035545 biolink:NamedThing determination of left/right asymmetry in nervous system The establishment of the nervous system with respect to the left and right halves. got7fsn_ti bf 2010-05-11T01:53:33Z biological_process owl:Class GO:0070854 biolink:NamedThing myosin VI heavy chain binding Binding to a heavy chain of a myosin VI complex. got7fsn_ti mah 2009-08-13T01:44:05Z molecular_function owl:Class GO:0070853 biolink:NamedThing myosin VI binding Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. got7fsn_ti mah 2009-08-13T01:28:36Z molecular_function owl:Class GO:0016560 biolink:NamedThing protein import into peroxisome matrix, docking The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane. got7fsn_ti protein docking during protein import into peroxisome matrix|protein transport into peroxisome matrix, docking|protein docking during protein transport into peroxisome matrix|peroxisome matrix protein import, docking|peroxisome receptor docking|protein docking during peroxisome matrix protein import biological_process owl:Class GO:0008104 biolink:NamedThing protein localization Any process in which a protein is transported to, or maintained in, a specific location. got7fsn_ti asymmetric protein localisation|establishment and maintenance of asymmetric protein localization|protein localisation|asymmetric protein localization|establishment and maintenance of protein localization GO:0008105 biological_process owl:Class GO:0030125 biolink:NamedThing clathrin vesicle coat A clathrin coat found on a vesicle. got7fsn_ti cellular_component owl:Class GO:0030118 biolink:NamedThing clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. got7fsn_ti clathrin cage GO:0016190 Wikipedia:Clathrin|NIF_Subcellular:sao879919129 cellular_component owl:Class GO:0044845 biolink:NamedThing chain elongation of O-linked mannose residue Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules. got7fsn_ti Example annotations to this term include the S. cerevisiae alpha1,2-mannosyltransferases ScKre2p, ScKtr1p and ScKtr3pof the KTR family. jl 2014-05-08T15:56:39Z biological_process owl:Class GO:0035268 biolink:NamedThing protein mannosylation The addition of a mannose residue to a protein acceptor molecule. got7fsn_ti protein amino acid mannosylation biological_process owl:Class GO:0004632 biolink:NamedThing phosphopantothenate--cysteine ligase activity Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. got7fsn_ti (R)-4'-phosphopantothenate:L-cysteine ligase activity|phosphopantothenate-cysteine ligase activity|phosphopantothenoylcysteine synthetase activity Reactome:R-HSA-196753|RHEA:19397|EC:6.3.2.5|MetaCyc:P-PANTOCYSLIG-RXN molecular_function owl:Class GO:0016881 biolink:NamedThing acid-amino acid ligase activity Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti peptide synthase activity EC:6.3.2.- molecular_function owl:Class GO:0097143 biolink:NamedThing PUMA-BCL-xl complex A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:44:10Z cellular_component owl:Class GO:0097136 biolink:NamedThing Bcl-2 family protein complex A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. got7fsn_ti pr 2011-08-02T01:34:19Z cellular_component owl:Class GO:0033131 biolink:NamedThing regulation of glucokinase activity Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. got7fsn_ti glucokinase regulator biological_process owl:Class GO:0010906 biolink:NamedThing regulation of glucose metabolic process Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. got7fsn_ti regulation of glucose metabolism biological_process owl:Class GO:0047435 biolink:NamedThing 5-guanidino-2-oxopentanoate decarboxylase activity Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO(2). got7fsn_ti 2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)|2-oxo-5-guanidinopentanoate decarboxylase activity|alpha-ketoarginine decarboxylase activity|2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity|2-oxo-5-guanidinopentanoate carboxy-lyase activity MetaCyc:4.1.1.75-RXN|KEGG_REACTION:R03178|RHEA:11340|EC:4.1.1.75 molecular_function owl:Class GO:0018519 biolink:NamedThing cis-dihydroethylcatechol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH. got7fsn_ti cis-ethylbenzene glycol dehydrogenase activity|cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity MetaCyc:1.3.1.66-RXN|RHEA:18101|UM-BBD_reactionID:r0309|EC:1.3.1.66|KEGG_REACTION:R05313 molecular_function owl:Class GO:0097057 biolink:NamedThing TRAF2-GSTP1 complex A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses. got7fsn_ti pr 2011-05-26T10:35:45Z cellular_component owl:Class GO:0052905 biolink:NamedThing tRNA (guanine(9)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine. got7fsn_ti tRNA(m(1)G(9)/m(1)A(9))Mtase activity|tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity|tRNA m(1)G(9) Mtase activity|tRNA (guanine-N(1)-)-methyltransferase activity|tRNA m(1)G(9)-methyltransferase activity EC:2.1.1.221|RHEA:43156|MetaCyc:RXN-12459 molecular_function owl:Class GO:0009019 biolink:NamedThing tRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. got7fsn_ti transfer ribonucleate guanine 1-methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity|tRNA guanine 1-methyltransferase activity Reactome:R-HSA-6782859|Reactome:R-HSA-6786621|Reactome:R-HSA-6787591 molecular_function owl:Class GO:0071363 biolink:NamedThing cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. got7fsn_ti mah 2009-12-11T03:05:07Z biological_process owl:Class GO:0046467 biolink:NamedThing membrane lipid biosynthetic process The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. got7fsn_ti membrane lipid synthesis|membrane lipid biosynthesis|membrane lipid anabolism|membrane lipid formation biological_process owl:Class GO:0048800 biolink:NamedThing antennal morphogenesis The process in which the anatomical structures of the antenna are generated and organized. got7fsn_ti biological_process owl:Class GO:0001555 biolink:NamedThing oocyte growth The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. got7fsn_ti biological_process owl:Class GO:0051723 biolink:NamedThing protein methylesterase activity Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol. got7fsn_ti protein carboxylic ester hydrolase activity|protein methyl-esterase activity|protein carboxyl methylesterase activity|PME activity Reactome:R-HSA-5367022 molecular_function owl:Class GO:0072764 biolink:NamedThing cellular response to reversine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus. got7fsn_ti mah 2012-11-09T11:52:22Z biological_process owl:Class GO:0071415 biolink:NamedThing cellular response to purine-containing compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. got7fsn_ti cellular response to purine mah 2009-12-14T03:12:20Z biological_process owl:Class GO:0102510 biolink:NamedThing pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+. got7fsn_ti MetaCyc:RXN-14439|EC:2.4.1.299 molecular_function owl:Class GO:0072756 biolink:NamedThing cellular response to paraquat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus. got7fsn_ti mah 2012-11-07T12:08:59Z biological_process owl:Class GO:0071310 biolink:NamedThing cellular response to organic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. got7fsn_ti mah 2009-12-10T04:46:04Z biological_process owl:Class GO:0003886 biolink:NamedThing DNA (cytosine-5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. got7fsn_ti deoxyribonucleic acid (cytosine-5-)-methyltransferase activity|type II DNA methylase activity|DNA cytosine methylase activity|DNA cytosine C5 methylase activity|methylphosphotriester-DNA methyltransferase activity|cytosine DNA methylase activity|DNA-cytosine 5-methylase activity|deoxyribonucleic (cytosine-5-)-methyltransferase activity|deoxyribonucleic methylase activity|cytosine DNA methyltransferase activity|restriction-modification system activity|cytosine-specific DNA methyltransferase activity|site-specific DNA-methyltransferase (cytosine-specific) activity|modification methylase activity|DNA 5-cytosine methylase activity|DNA cytosine C(5) methylase activity|cytosine 5-methyltransferase activity|DNA-cytosine methyltransferase activity|S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). GO:0008326 EC:2.1.1.37|MetaCyc:2.1.1.73-RXN|RHEA:13681 molecular_function owl:Class GO:0009008 biolink:NamedThing DNA-methyltransferase activity Catalysis of the transfer of a methyl group to a DNA molecule. got7fsn_ti DNA transmethylase activity|deoxyribonucleate methyltransferase activity|deoxyribonucleic acid methylase activity|DNA methylase|Type II DNA methylase|deoxyribonucleate methylase activity|deoxyribonucleic acid methyltransferase activity|deoxyribonucleic acid modification methylase activity|DNA methyltransferase activity Reactome:R-HSA-5227490 molecular_function owl:Class GO:1902441 biolink:NamedThing protein localization to meiotic spindle pole body A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body. got7fsn_ti protein localisation in meiotic spindle pole body|protein localization in meiotic spindle pole body|protein localisation to meiotic spindle pole body|protein location to meiotic spindle pole body|establishment of protein localization to meiotic spindle pole body mah 2013-10-10T14:45:04Z GO:1990945|GO:1990954 biological_process owl:Class GO:0033408 biolink:NamedThing UCG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UCG codon. got7fsn_ti TCG codon-amino acid adaptor activity|serine tRNA Note that in the standard genetic code, TCG codes for serine. molecular_function owl:Class GO:0072105 biolink:NamedThing ureteric peristalsis A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder. got7fsn_ti mah 2010-02-10T03:07:54Z biological_process owl:Class GO:0030432 biolink:NamedThing peristalsis A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. got7fsn_ti Wikipedia:Peristalsis biological_process owl:Class GO:0030686 biolink:NamedThing 90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. got7fsn_ti cellular_component owl:Class GO:0030684 biolink:NamedThing preribosome Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. got7fsn_ti cellular_component owl:Class GO:0031726 biolink:NamedThing CCR1 chemokine receptor binding Binding to a CCR1 chemokine receptor. got7fsn_ti macrophage inflammatory protein-1 alpha receptor binding|CCR1 chemokine receptor ligand molecular_function owl:Class GO:0048020 biolink:NamedThing CCR chemokine receptor binding Binding to a CCR chemokine receptor. got7fsn_ti beta chemokine receptor ligand|CCR chemokine receptor ligand|beta chemokine receptor binding molecular_function owl:Class GO:0030870 biolink:NamedThing Mre11 complex Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. got7fsn_ti RAD50-MRE11-NBN complex|Rad50-Rad32-Nbs1 complex|MRN complex|Rad50 complex|RMX complex|MRX complex cellular_component owl:Class GO:0046957 biolink:NamedThing negative phototaxis The directed movement of a cell or organism away from a source of light. got7fsn_ti negative phototactic behavior|negative taxis in response to light|negative phototactic behaviour GO:0046955 biological_process owl:Class GO:0052129 biolink:NamedThing negative energy taxis The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. got7fsn_ti biological_process owl:Class GO:0033974 biolink:NamedThing nucleoside phosphoacylhydrolase activity Catalysis of the hydrolysis of mixed phospho-anhydride bonds. got7fsn_ti nucleoside-5'-phosphoacylate acylhydrolase activity EC:3.6.1.24|MetaCyc:3.6.1.24-RXN molecular_function owl:Class GO:0016818 biolink:NamedThing hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. got7fsn_ti EC:3.6.1.- molecular_function owl:Class GO:0033872 biolink:NamedThing [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. got7fsn_ti heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity|glucosaminyl 3-O-sulfotransferase 3a, 3b activity|3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity|3-OST-3|heparin-glucosamine 3-sulfotransferase 3 activity|glucosaminyl 3-O-sulfotransferase 3 activity|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity|isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B) MetaCyc:2.8.2.30-RXN|EC:2.8.2.30 molecular_function owl:Class GO:0034483 biolink:NamedThing heparan sulfate sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. got7fsn_ti molecular_function owl:Class GO:0035768 biolink:NamedThing endothelial cell chemotaxis to fibroblast growth factor The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF). got7fsn_ti bf 2011-03-31T04:32:17Z biological_process owl:Class GO:0035767 biolink:NamedThing endothelial cell chemotaxis The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti bf 2011-03-31T04:31:37Z biological_process owl:Class GO:0042037 biolink:NamedThing peptidyl-histidine methylation, to form pros-methylhistidine The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). got7fsn_ti peptidyl-histidine pros-methylation GO:0042260 RESID:AA0073 biological_process owl:Class GO:0018021 biolink:NamedThing peptidyl-histidine methylation The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). got7fsn_ti RESID:AA0073|RESID:AA0317 biological_process owl:Class GO:0043098 biolink:NamedThing purine deoxyribonucleoside salvage Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class GO:0046123 biolink:NamedThing purine deoxyribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). got7fsn_ti purine deoxyribonucleoside anabolism|purine deoxyribonucleoside formation|purine deoxyribonucleoside biosynthesis|purine deoxyribonucleoside synthesis biological_process owl:Class GO:0009649 biolink:NamedThing entrainment of circadian clock The synchronization of a circadian rhythm to environmental time cues such as light. got7fsn_ti regulation of circadian rhythm phase biological_process owl:Class GO:0018964 biolink:NamedThing propylene metabolic process The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals. got7fsn_ti propylene metabolism UM-BBD_pathwayID:pro biological_process owl:Class GO:0006805 biolink:NamedThing xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti drug metabolism|xenobiotic metabolism|drug metabolic process https://github.com/geneontology/go-ontology/issues/19460 GO:0017144 Wikipedia:Xenobiotic_metabolism|Wikipedia:Drug_metabolism biological_process owl:Class GO:0045462 biolink:NamedThing trichothecene 3-O-acetyltransferase activity Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis. got7fsn_ti molecular_function owl:Class GO:0040024 biolink:NamedThing dauer larval development The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. got7fsn_ti biological_process owl:Class GO:0002119 biolink:NamedThing nematode larval development The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. got7fsn_ti biological_process owl:Class GO:0008967 biolink:NamedThing phosphoglycolate phosphatase activity Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate. got7fsn_ti phosphoglycolate hydrolase activity|P-glycolate phosphatase activity|phosphoglycollate phosphatase activity|2-phosphoglycolate phosphohydrolase activity|2-phosphoglycolate phosphatase activity RHEA:14369|EC:3.1.3.18|KEGG_REACTION:R01334|MetaCyc:GPH-RXN molecular_function owl:Class GO:0016791 biolink:NamedThing phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. got7fsn_ti PNPPase activity|nitrophenyl phosphatase activity|para-nitrophenyl phosphatase activity|phosphatase|p-nitrophenylphosphate phosphohydrolase activity|phosphoric monoester hydrolase activity|4-nitrophenylphosphate phosphohydrolase activity|ecto-p-nitrophenyl phosphatase activity|NPPase activity|p-nitrophenylphosphatase activity|K-pNPPase activity|4-nitrophenylphosphatase activity GO:0003869|GO:0016302 Reactome:R-HSA-9636457|Reactome:R-HSA-4419986|MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN|EC:3.1.3.- molecular_function owl:Class GO:0031837 biolink:NamedThing substance K receptor binding Binding to a substance K receptor. got7fsn_ti substance K receptor ligand|neurokinin-A receptor binding molecular_function owl:Class GO:0031834 biolink:NamedThing neurokinin receptor binding Binding to a neurokinin receptor. got7fsn_ti neurokinin receptor ligand molecular_function owl:Class GO:0071047 biolink:NamedThing polyadenylation-dependent mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. got7fsn_ti poly(A)-dependent mRNA catabolic process https://github.com/geneontology/go-ontology/issues/20568 krc 2009-08-07T09:57:56Z biological_process owl:Class GO:0043633 biolink:NamedThing polyadenylation-dependent RNA catabolic process The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA. got7fsn_ti polyadenylation-dependent RNA catabolic process biological_process owl:Class GO:0009535 biolink:NamedThing chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. got7fsn_ti cellular_component owl:Class GO:0055035 biolink:NamedThing plastid thylakoid membrane The lipid bilayer membrane of any thylakoid within a plastid. got7fsn_ti cellular_component owl:Class GO:0008707 biolink:NamedThing 4-phytase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate. got7fsn_ti phytate 6-phosphatase activity|6-phytase activity|6-phytase (name based on 1L-numbering system and not 1D-numbering)|myo-inositol-hexakisphosphate 6-phosphohydrolase activity|phytase activity MetaCyc:6-PHYT-RXN|EC:3.1.3.26|RHEA:20960 molecular_function owl:Class GO:0004447 biolink:NamedThing iodide peroxidase activity Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O. got7fsn_ti thyroperoxidase activity|iodinase activity|TPO activity|thyroid peroxidase activity https://github.com/geneontology/go-ontology/issues/21027 MetaCyc:IODIDE-PEROXIDASE-RXN|EC:1.11.1.8 molecular_function owl:Class GO:0004601 biolink:NamedThing peroxidase activity Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. got7fsn_ti horseradish peroxidase (HRP)|peroxidase reaction|verdoperoxidase|protoheme peroxidase|MPO|secretory plant peroxidase activity|oxyperoxidase activity|heme peroxidase|guaiacol peroxidase|thiocyanate peroxidase|myeloperoxidase activity|lactoperoxidase activity|donor:hydrogen-peroxide oxidoreductase activity|pyrocatechol peroxidase|japanese radish peroxidase|scopoletin peroxidase|bacterial catalase-peroxidase activity|extensin peroxidase|eosinophil peroxidase activity GO:0016685|GO:0016686|GO:0016687|GO:0016693 Reactome:R-HSA-6789126|Reactome:R-HSA-209840|EC:1.11.1.-|Reactome:R-HSA-140359|Reactome:R-HSA-350901|Reactome:R-HSA-5631885|Reactome:R-HSA-2559639|Reactome:R-HSA-209925|KEGG_REACTION:R03532|Reactome:R-HSA-209973|Reactome:R-HSA-209815|Reactome:R-HSA-1222346|Reactome:R-HSA-3341296|Reactome:R-HSA-8933635|Reactome:R-HSA-6789031|MetaCyc:PEROXID-RXN|Reactome:R-HSA-8855490|Reactome:R-HSA-2309773 molecular_function owl:Class GO:0071464 biolink:NamedThing cellular response to hydrostatic pressure Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. got7fsn_ti cellular response to biomechanical stress|cellular response to static fluid pressure mah 2009-12-18T11:34:07Z biological_process owl:Class GO:0051599 biolink:NamedThing response to hydrostatic pressure Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. got7fsn_ti response to biomechanical stress|response to static fluid pressure biological_process owl:Class GO:0009036 biolink:NamedThing type II site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site. got7fsn_ti type II restriction enzyme activity EC:3.1.21.4|MetaCyc:3.1.21.4-RXN molecular_function owl:Class GO:0015666 biolink:NamedThing restriction endodeoxyribonuclease activity Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. got7fsn_ti restriction enzyme activity|restriction endonuclease activity molecular_function owl:Class GO:0097191 biolink:NamedThing extrinsic apoptotic signaling pathway A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. got7fsn_ti extrinsic apoptosis|extrinsic apoptotic pathway|extrinsic apoptotic signalling pathway|extrinsic apoptotic signaling pathway in presence of ligand|death receptor-mediated apoptosis Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer. pr 2011-11-23T09:34:28Z biological_process owl:Class GO:0007166 biolink:NamedThing cell surface receptor signaling pathway A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti cell surface receptor linked signaling pathway|cell surface receptor linked signalling pathway|cell surface receptor linked signal transduction biological_process owl:Class GO:0046619 biolink:NamedThing lens placode formation involved in camera-type eye formation Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles. got7fsn_ti optic placode formation involved in camera-style eye|optic placode formation in camera-type eye|optic placode formation involved in camera-type eye formation biological_process owl:Class GO:0001743 biolink:NamedThing lens placode formation The initial developmental process that will lead to the formation of an eye. got7fsn_ti optic placode formation biological_process owl:Class GO:0030520 biolink:NamedThing intracellular estrogen receptor signaling pathway Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). got7fsn_ti estrogen receptor signaling pathway|estrogen receptor signalling pathway biological_process owl:Class GO:0030518 biolink:NamedThing intracellular steroid hormone receptor signaling pathway A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands. got7fsn_ti steroid hormone receptor signalling pathway|steroid hormone receptor signaling pathway biological_process owl:Class GO:0031635 biolink:NamedThing adenylate cyclase-inhibiting opioid receptor signaling pathway The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). got7fsn_ti inhibition of adenylate cyclase activity by opioid receptor signalling pathway|opioid receptor, adenylate cyclase inhibiting pathway|inhibition of adenylate cyclase activity by opioid receptor signaling pathway biological_process owl:Class GO:0007193 biolink:NamedThing adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). got7fsn_ti G protein signaling, adenylyl cyclase inhibiting pathway|GPCR signaling pathway via inhibition of adenylate cyclase activity|G-protein signaling, adenylyl cyclase inhibiting pathway|G protein signalling, adenylate cyclase inhibiting pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|G-protein signalling, adenylate cyclase inhibiting pathway|G-protein signalling, adenylyl cyclase inhibiting pathway|G protein signaling, adenylate cyclase inhibiting pathway|adenylate cyclase-inhibiting GPCR signaling pathway|G-protein signaling, adenylate cyclase inhibiting pathway|G protein signalling, adenylyl cyclase inhibiting pathway This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition. biological_process owl:Class GO:0045476 biolink:NamedThing nurse cell apoptotic process Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process. got7fsn_ti apoptosis of nurse cells|nurse cell apoptosis|programmed cell death of nurse cells by apoptosis|invertebrate nurse cell apoptosis|nurse cell programmed cell death by apoptosis biological_process owl:Class GO:0006915 biolink:NamedThing apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. got7fsn_ti apoptosis activator activity|commitment to apoptosis|apoptotic program|cellular suicide|programmed cell death by apoptosis|cell suicide|caspase-dependent programmed cell death|apoptotic cell death|type I programmed cell death|apoptotic programmed cell death|signaling (initiator) caspase activity|apoptosis signaling|induction of apoptosis|apoptosis|activation of apoptosis|induction of apoptosis by p53 GO:0006917|GO:0008632 Wikipedia:Apoptosis biological_process owl:Class GO:0046753 biolink:NamedThing non-lytic viral release The exit of a viral particle from a cell that does not involve cell lysis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18852 biological_process owl:Class GO:0019076 biolink:NamedThing viral release from host cell The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane. got7fsn_ti viral shedding|viral exit|release of virus from host|virus exit from host cell|viral release VZ:1076 biological_process owl:Class GO:0018360 biolink:NamedThing protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine. got7fsn_ti protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine GO:0018384 RESID:AA0271 biological_process owl:Class GO:0046559 biolink:NamedThing alpha-glucuronidase activity Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate. got7fsn_ti alpha-glucosiduronase activity|alpha-D-glucosiduronate glucuronohydrolase activity RHEA:20005|EC:3.2.1.139|MetaCyc:3.2.1.139-RXN molecular_function owl:Class GO:0018116 biolink:NamedThing peptidyl-lysine adenylylation The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine. got7fsn_ti peptidyl-lysine adenylation RESID:AA0227 biological_process owl:Class GO:0018205 biolink:NamedThing peptidyl-lysine modification The modification of peptidyl-lysine. got7fsn_ti biological_process owl:Class GO:0035469 biolink:NamedThing determination of pancreatic left/right asymmetry Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism. got7fsn_ti bf 2010-04-22T10:47:15Z biological_process owl:Class GO:0106029 biolink:NamedThing tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. got7fsn_ti tRNA pseudouridine(32) synthase|tRNA pseudouridine(65) synthase|transfer ribonucleate pseudouridine synthetase activity|tRNA pseudouridine(13) synthase|tRNA-pseudouridine synthase activity|tRNA pseudouridine(31) synthase|tRNA pseudouridine(38-40) synthase|tRNA pseudouridylate synthase I activity|tRNA-pseudouridine synthase I activity|tRNA-uridine isomerase activity|tRNA pseudouridine(55) synthase|tRNA pseudouridine(38/39) synthase|tRNA-uridine uracilmutase activity|transfer RNA pseudouridine synthetase activity|Mitochondrial tRNA pseudouridine(27/28) synthase hjd 2017-06-26T17:37:30Z EC:5.4.99.42|EC:5.4.99.26|EC:5.4.99.44|RHEA:22376|MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN|EC:5.4.99.12|EC:5.4.99.45|EC:5.4.99.28|EC:5.4.99.27|EC:5.4.99.25 molecular_function owl:Class GO:0009982 biolink:NamedThing pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. got7fsn_ti Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. GO:0016439 Reactome:R-HSA-6782381|Reactome:R-HSA-6787566|Reactome:R-HSA-6790905|Reactome:R-HSA-8870289|Reactome:R-HSA-6786583 molecular_function owl:Class GO:0097374 biolink:NamedThing sensory neuron axon guidance The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses. got7fsn_ti pr 2012-10-01T10:16:22Z biological_process owl:Class GO:0007411 biolink:NamedThing axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. got7fsn_ti axon pathfinding|axon chemotaxis|axon growth cone guidance GO:0008040 Wikipedia:Axon_guidance biological_process owl:Class GO:0001120 biolink:NamedThing protein-DNA complex remodeling The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex. got7fsn_ti krc 2010-12-03T04:17:15Z biological_process owl:Class GO:0071824 biolink:NamedThing protein-DNA complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. got7fsn_ti DNA-protein complex subunit organization|protein-DNA complex subunit organisation mah 2010-09-08T10:03:26Z biological_process owl:Class GO:0018558 biolink:NamedThing 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0049 molecular_function owl:Class GO:0098648 biolink:NamedThing collagen anchoring fibril A specialised collagen fibril that functions as an anchor, binding to other collagen structures. got7fsn_ti cellular_component owl:Class GO:0098644 biolink:NamedThing complex of collagen trimers A complex of collagen trimers such as a fibril or collagen network. got7fsn_ti Supramolecular collagen assembly|Supramolecular aggregate of collagen cellular_component owl:Class GO:0106097 biolink:NamedThing cellular response to ceramide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus. got7fsn_ti hjd 2018-02-12T19:52:55Z biological_process owl:Class GO:0071396 biolink:NamedThing cellular response to lipid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. got7fsn_ti mah 2009-12-11T04:37:10Z biological_process owl:Class GO:0003983 biolink:NamedThing UTP:glucose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. got7fsn_ti uridine diphosphate-D-glucose pyrophosphorylase activity|UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity|uridine diphosphoglucose pyrophosphorylase activity|UDP glucose pyrophosphorylase activity|uridine-diphosphate glucose pyrophosphorylase activity|UDPG pyrophosphorylase activity|UTP-glucose-1-phosphate uridylyltransferase activity|UDPG phosphorylase activity|glucose-1-phosphate uridylyltransferase activity|UDP-glucose diphosphorylase activity|UDP-glucose pyrophosphorylase activity|uridine 5'-diphosphoglucose pyrophosphorylase activity EC:2.7.7.9|Reactome:R-HSA-70286|RHEA:19889|KEGG_REACTION:R00289|MetaCyc:GLUC1PURIDYLTRANS-RXN molecular_function owl:Class GO:0051748 biolink:NamedThing UTP-monosaccharide-1-phosphate uridylyltransferase activity Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide. got7fsn_ti UDP-monosaccharide diphosphorylase activity|USP|PsUSP|UDP-sugar pyrophosphorylase activity|UDP-monosaccharide pyrophosphorylase activity MetaCyc:2.7.7.64-RXN|EC:2.7.7.64|RHEA:13205 molecular_function owl:Class GO:0009496 biolink:NamedThing plastoquinol--plastocyanin reductase activity Catalysis of the reaction: 2 H(+)[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H(+)[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane. got7fsn_ti cytochrome b6f|plastoquinol-plastocyanin reductase activity|cytochrome b6f complex activity|plastoquinol:oxidized-plastocyanin oxidoreductase activity|plastoquinol/plastocyanin oxidoreductase activity EC:7.1.1.6|KEGG_REACTION:R03817|MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN|RHEA:22148 molecular_function owl:Class GO:0032195 biolink:NamedThing post-lysosomal vacuole A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis. got7fsn_ti post-lysosome cellular_component owl:Class GO:0030139 biolink:NamedThing endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. got7fsn_ti endocytotic vesicle|endocytotic transport vesicle NIF_Subcellular:sao1362520468 cellular_component owl:Class GO:0008762 biolink:NamedThing UDP-N-acetylmuramate dehydrogenase activity Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. got7fsn_ti uridine diphosphoacetylpyruvoylglucosamine reductase activity|uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity|UDP-N-acetylenolpyruvoylglucosamine reductase activity|MurB reductase|UDP-GlcNAc-enoylpyruvate reductase activity|UDP-N-acetylmuramate:NADP+ oxidoreductase activity|UDP-N-acetylglucosamine-enoylpyruvate reductase activity|uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN|RHEA:12248|EC:1.3.1.98 molecular_function owl:Class GO:0090253 biolink:NamedThing convergent extension involved in imaginal disc-derived wing morphogenesis The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis. got7fsn_ti tb 2010-01-22T11:40:46Z biological_process owl:Class GO:0009886 biolink:NamedThing post-embryonic animal morphogenesis The process, occurring after animal embryonic development, by which anatomical structures are generated and organized. got7fsn_ti post-embryonic morphogenesis of an anatomical structure biological_process owl:Class GO:0046774 biolink:NamedThing suppression by virus of host intracellular interferon activity Any viral process that results in the inhibition of interferon activity within the host cell. got7fsn_ti suppression by virus of intracellular interferon activity in host|negative regulation by virus of intracellular interferon activity biological_process owl:Class GO:0030683 biolink:NamedThing mitigation of host immune response by virus A process by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti suppression of host extracellular antiviral response by virus|negative regulation by virus of intracellular antiviral response|negative regulation by virus of extracellular antiviral response|evasion by virus of host immune response|evasion or tolerance by virus of host immune response|suppression by virus of host extracellular antiviral response|negative regulation of host intracellular antiviral response by virus|viral inhibition of intracellular antiviral response|mitigation by virus of host immune response|suppression by virus of host intracellular antiviral response|suppression by virus of host immune response|suppression of host intracellular antiviral response by virus|negative regulation of host extracellular antiviral response by virus|inhibition of extracellular antiviral response GO:0019052|GO:0019053 biological_process owl:Class GO:0044514 biolink:NamedThing envenomation resulting in positive regulation of G protein-coupled receptor activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G protein-coupled receptor activity in of the bitten organism. got7fsn_ti envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism jl 2012-02-26T11:06:15Z biological_process owl:Class GO:0044513 biolink:NamedThing envenomation resulting in modulation of G protein-coupled receptor activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G protein-coupled receptor activity in of the bitten organism. got7fsn_ti envenomation resulting in modulation of G-protein coupled receptor activity in other organism jl 2012-02-26T11:02:17Z biological_process owl:Class GO:0032879 biolink:NamedThing regulation of localization Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. got7fsn_ti regulation of localisation biological_process owl:Class GO:0050789 biolink:NamedThing regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. got7fsn_ti regulation of physiological process GO:0050791 biological_process owl:Class GO:0046525 biolink:NamedThing xylosylprotein 4-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein. got7fsn_ti UDP-D-galactose:xylose galactosyltransferase activity|UDP-D-galactose:D-xylose galactosyltransferase activity|UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity|uridine diphosphogalactose-xylose galactosyltransferase activity|UDP-galactose:xylose galactosyltransferase activity|galactosyltransferase I activity|UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity EC:2.4.1.133|RHEA:15297|MetaCyc:2.4.1.133-RXN|Reactome:R-HSA-1889981|Reactome:R-HSA-3560804 molecular_function owl:Class GO:0035250 biolink:NamedThing UDP-galactosyltransferase activity Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. got7fsn_ti molecular_function owl:Class GO:0140404 biolink:NamedThing effector-mediated modulation of host innate immune response by symbiont A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti effector-triggered modulation of host immune response by symbiont|effector triggered modulation of host immune response by symbiont|effector-dependent modulation of host immune response by symbiont|effector mediated modulation of host immune response by symbiont|effector-mediated modulation of host immunity pg 2019-12-05T11:38:44Z biological_process owl:Class GO:0140415 biolink:NamedThing effector-mediated modulation of host defenses by symbiont A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti pg 2020-01-20T16:46:41Z biological_process owl:Class GO:0120095 biolink:NamedThing vacuole-isolation membrane contact site An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome. got7fsn_ti vacuole-phagophore contact site|vacuole-IM contact site|VICS krc 2017-09-18T20:01:35Z cellular_component owl:Class GO:0044232 biolink:NamedThing organelle membrane contact site A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. got7fsn_ti MCS|inter-organelle junction|interorganelle junction https://github.com/geneontology/go-ontology/issues/18994 jl 2010-01-07T03:44:20Z cellular_component owl:Class GO:0016576 biolink:NamedThing histone dephosphorylation The modification of histones by removal of phosphate groups. got7fsn_ti biological_process owl:Class GO:0016570 biolink:NamedThing histone modification The covalent alteration of one or more amino acid residues within a histone protein. got7fsn_ti Wikipedia:Histone#Histone_modifications_in_chromatin_regulation biological_process owl:Class GO:0034783 biolink:NamedThing pivalate-CoA ligase activity Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP. got7fsn_ti UM-BBD_reactionID:r1032 molecular_function owl:Class GO:0016878 biolink:NamedThing acid-thiol ligase activity Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti EC:6.2.1.- molecular_function owl:Class GO:0046585 biolink:NamedThing enniatin biosynthetic process The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores. got7fsn_ti enniatin biosynthesis|enniatin anabolism|enniatin synthesis|enniatin formation biological_process owl:Class GO:0017000 biolink:NamedThing antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. got7fsn_ti antibiotic synthesis|antibiotic formation|antibiotic biosynthesis|antibiotic anabolism biological_process owl:Class GO:0042985 biolink:NamedThing negative regulation of amyloid precursor protein biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. got7fsn_ti inhibition of amyloid precursor protein biosynthetic process|down regulation of amyloid precursor protein biosynthetic process|negative regulation of amyloid precursor protein biosynthesis|downregulation of amyloid precursor protein biosynthetic process|negative regulation of amyloid precursor protein synthesis|down-regulation of amyloid precursor protein biosynthetic process|negative regulation of amyloid precursor protein formation|negative regulation of APP biosynthetic process|negative regulation of amyloid precursor protein anabolism|negative regulation of APP biosynthesis biological_process owl:Class GO:0010561 biolink:NamedThing negative regulation of glycoprotein biosynthetic process Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. got7fsn_ti biological_process owl:Class GO:0048640 biolink:NamedThing negative regulation of developmental growth Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. got7fsn_ti down-regulation of developmental growth|inhibition of developmental growth|downregulation of developmental growth|down regulation of developmental growth biological_process owl:Class GO:0048638 biolink:NamedThing regulation of developmental growth Any process that modulates the frequency, rate or extent of developmental growth. got7fsn_ti biological_process owl:Class GO:0051952 biolink:NamedThing regulation of amine transport Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class GO:0051049 biolink:NamedThing regulation of transport Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class GO:0042066 biolink:NamedThing perineurial glial growth Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons. got7fsn_ti biological_process owl:Class GO:0042065 biolink:NamedThing glial cell growth Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. got7fsn_ti biological_process owl:Class GO:0035608 biolink:NamedThing protein deglutamylation The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation. got7fsn_ti protein amino acid deglutamylation bf 2010-11-18T01:04:38Z biological_process owl:Class GO:0018200 biolink:NamedThing peptidyl-glutamic acid modification The modification of peptidyl-glutamic acid. got7fsn_ti biological_process owl:Class GO:0042549 biolink:NamedThing photosystem II stabilization The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. got7fsn_ti biological_process owl:Class GO:0061485 biolink:NamedThing memory T cell proliferation The expansion of a memory T cell population by cell division. got7fsn_ti dph 2012-12-04T09:52:54Z biological_process owl:Class GO:0042098 biolink:NamedThing T cell proliferation The expansion of a T cell population by cell division. Follows T cell activation. got7fsn_ti T-lymphocyte proliferation|T-cell proliferation|T lymphocyte proliferation GO:0042111 biological_process owl:Class GO:0002305 biolink:NamedThing CD8-positive, gamma-delta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti CD8-positive, gamma-delta intraepithelial T-cell differentiation|CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation|CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation|CD8-positive, gamma-delta intraepithelial T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:0002304 biolink:NamedThing gamma-delta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti gamma-delta intraepithelial T lymphocyte differentiation|gamma-delta intraepithelial T-cell differentiation|gamma-delta intraepithelial T-lymphocyte differentiation|gamma-delta intraepithelial T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:0016063 biolink:NamedThing rhodopsin biosynthetic process The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. got7fsn_ti rhodopsin formation|rhodopsin biosynthesis|rhodopsin anabolism|rhodopsin synthesis biological_process owl:Class GO:0006726 biolink:NamedThing eye pigment biosynthetic process The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. got7fsn_ti eye pigment anabolism|eye pigment synthesis|eye pigment formation|eye pigment biosynthesis biological_process owl:Class GO:0016860 biolink:NamedThing intramolecular oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. got7fsn_ti intramolecular oxidoreductase activity, other intramolecular oxidoreductases|intramolecular isomerase activity EC:5.3.-.-|Reactome:R-HSA-109998 molecular_function owl:Class GO:0060096 biolink:NamedThing serotonin secretion, neurotransmission The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter. got7fsn_ti serotonin release, neurotransmission biological_process owl:Class GO:0001820 biolink:NamedThing serotonin secretion The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. got7fsn_ti 5-HT secretion|serotonin release|5-hydroxytryptamine secretion biological_process owl:Class GO:1990775 biolink:NamedThing endothelin production The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. got7fsn_ti EDN2 production|endothelin secretion|endothelin-3 production|EDN1 production|endothelin-2 production|EDN3 production|endothelin-1 secretion sl 2015-06-15T23:13:18Z biological_process owl:Class GO:0001816 biolink:NamedThing cytokine production The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti cytokine secretion|cytokine biosynthetic process|cytokine metabolic process|interleukin production|interferon production|interleukin secretion|interferon secretion https://github.com/geneontology/go-ontology/issues/19116 Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. GO:0042032|GO:0042107|GO:0042089|GO:0050663 biological_process owl:Class GO:0009225 biolink:NamedThing nucleotide-sugar metabolic process The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. got7fsn_ti nucleotide-sugar metabolism https://github.com/geneontology/go-ontology/issues/14587 biological_process owl:Class GO:0055086 biolink:NamedThing nucleobase-containing small molecule metabolic process The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. got7fsn_ti nucleobase, nucleoside and nucleotide metabolic process|nucleobase, nucleoside and nucleotide metabolism biological_process owl:Class GO:0018165 biolink:NamedThing peptidyl-tyrosine uridylylation The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase. got7fsn_ti RESID:AA0256 biological_process owl:Class GO:0018212 biolink:NamedThing peptidyl-tyrosine modification The modification of peptidyl-tyrosine. got7fsn_ti biological_process owl:Class GO:2000147 biolink:NamedThing positive regulation of cell motility Any process that activates or increases the frequency, rate or extent of cell motility. got7fsn_ti positive regulation of movement of a cell|positive regulation of cell movement|positive regulation of cell locomotion mah 2010-10-01T09:41:30Z biological_process owl:Class GO:2000145 biolink:NamedThing regulation of cell motility Any process that modulates the frequency, rate or extent of cell motility. got7fsn_ti regulation of cell locomotion|regulation of cell movement|regulation of movement of a cell mah 2010-10-01T09:41:21Z biological_process owl:Class GO:0002164 biolink:NamedThing larval development The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. got7fsn_ti biological_process owl:Class GO:0009791 biolink:NamedThing post-embryonic development The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. got7fsn_ti biological_process owl:Class GO:0140103 biolink:NamedThing catalytic activity, acting on a glycoprotein Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-15T19:27:54Z molecular_function owl:Class GO:0007458 biolink:NamedThing progression of morphogenetic furrow involved in compound eye morphogenesis The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc. got7fsn_ti progression of morphogenetic furrow during compound eye morphogenesis biological_process owl:Class GO:0009967 biolink:NamedThing positive regulation of signal transduction Any process that activates or increases the frequency, rate or extent of signal transduction. got7fsn_ti upregulation of signal transduction|up regulation of signal transduction|stimulation of signal transduction|activation of signal transduction|positive regulation of signaling pathway|up-regulation of signal transduction|positive regulation of signalling pathway GO:0035468 biological_process owl:Class GO:0022008 biolink:NamedThing neurogenesis Generation of cells within the nervous system. got7fsn_ti nervous system cell generation|neural cell differentiation Wikipedia:Neurogenesis biological_process owl:Class GO:0030154 biolink:NamedThing cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. got7fsn_ti Wikipedia:Cellular_differentiation biological_process owl:Class GO:0060447 biolink:NamedThing bud outgrowth involved in lung branching The process in which a region of the lung epithelium initiates an outgrowth. got7fsn_ti bud formation involved in lung branching biological_process owl:Class GO:0060602 biolink:NamedThing branch elongation of an epithelium The growth process in which a branch increases in length from its base to its tip. got7fsn_ti dph 2009-05-14T02:45:44Z biological_process owl:Class GO:0033692 biolink:NamedThing cellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell. got7fsn_ti cellular glycan biosynthesis|cellular polysaccharide biosynthesis|cellular polysaccharide anabolism|cellular glycan biosynthetic process|cellular polysaccharide synthesis|cellular polysaccharide formation biological_process owl:Class GO:0034637 biolink:NamedThing cellular carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. got7fsn_ti biological_process owl:Class GO:0035878 biolink:NamedThing nail development The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it. got7fsn_ti bf 2011-05-31T02:30:34Z biological_process owl:Class GO:0034597 biolink:NamedThing phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. got7fsn_ti 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity|inositol polyphosphate 4-phosphatase type II activity|phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity MetaCyc:3.1.3.66-RXN|Reactome:R-HSA-6810410|EC:3.1.3.66 molecular_function owl:Class GO:0034596 biolink:NamedThing phosphatidylinositol phosphate 4-phosphatase activity Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. got7fsn_ti PtdIns4P-phosphatase activity|phosphoinositide 4-phosphatase activity|inositol 4-phosphatase|PI(4)P-phosphatase activity|PI4P-phosphatase activity Reactome:R-HSA-1676133|Reactome:R-HSA-8849969|Reactome:R-HSA-1676124|Reactome:R-HSA-1675988 molecular_function owl:Class GO:0038131 biolink:NamedThing neuregulin receptor activity Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti NRG2 receptor activity|NRG1 receptor activity|NRG receptor activity Consider also annotating to 'ERBB3 signaling pathway ; GO:0038129' and/or 'ERBB4 signaling pathway ; GO:0038130'. bf 2012-03-30T10:47:11Z molecular_function owl:Class GO:0004888 biolink:NamedThing transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. got7fsn_ti transmembrane signalling receptor activity|transmembrane receptor activity This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. GO:0004926|GO:0099600 Reactome:R-HSA-193672 molecular_function owl:Class GO:0051061 biolink:NamedThing ADP reductase activity Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin. got7fsn_ti ADP reduction MetaCyc:ADPREDUCT-RXN|RHEA:28034 molecular_function owl:Class GO:0004748 biolink:NamedThing ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. got7fsn_ti 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity|2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity When thioredoxin is substituted for glutaredoxin in the reaction, annotate instead to 'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor ; GO:0036175'. GO:0016961|GO:0016960|GO:0016959 RHEA:23252|MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN|EC:1.17.4.1|Reactome:R-HSA-111804|Reactome:R-HSA-111751 molecular_function owl:Class GO:0098833 biolink:NamedThing presynaptic endocytic zone A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity. got7fsn_ti May be identical to periactive zone? cellular_component owl:Class GO:0110165 biolink:NamedThing cellular anatomical entity A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. got7fsn_ti kmv 2019-08-12T18:01:37Z cellular_component owl:Class GO:0034754 biolink:NamedThing cellular hormone metabolic process The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. got7fsn_ti biological_process owl:Class GO:0042445 biolink:NamedThing hormone metabolic process The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. got7fsn_ti hormone metabolism biological_process owl:Class GO:0070977 biolink:NamedThing bone maturation A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. got7fsn_ti mah 2009-10-05T04:35:31Z biological_process owl:Class GO:0071695 biolink:NamedThing anatomical structure maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. got7fsn_ti mah 2010-03-02T11:43:38Z biological_process owl:Class GO:2001151 biolink:NamedThing regulation of renal water transport Any process that modulates the frequency, rate or extent of renal water transport. got7fsn_ti yaf 2011-10-24T11:37:51Z biological_process owl:Class GO:0071470 biolink:NamedThing cellular response to osmotic stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. got7fsn_ti cellular osmotic stress response|cellular osmotic response mah 2009-12-18T11:45:33Z biological_process owl:Class GO:0062197 biolink:NamedThing cellular response to chemical stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress. got7fsn_ti dph 2019-12-10T14:42:03Z biological_process owl:Class GO:0044790 biolink:NamedThing negative regulation by host of viral release from host cell A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells. got7fsn_ti jl 2013-06-06T10:51:27Z biological_process owl:Class GO:0044793 biolink:NamedThing negative regulation by host of viral process A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected. got7fsn_ti jl 2013-06-06T11:16:00Z biological_process owl:Class GO:0046005 biolink:NamedThing positive regulation of circadian sleep/wake cycle, REM sleep Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep. got7fsn_ti stimulation of circadian sleep/wake cycle, REM sleep|activation of circadian sleep/wake cycle, REM sleep|upregulation of circadian sleep/wake cycle, REM sleep|up regulation of circadian sleep/wake cycle, REM sleep|positive regulation of REM sleep|up-regulation of circadian sleep/wake cycle, REM sleep biological_process owl:Class GO:0045938 biolink:NamedThing positive regulation of circadian sleep/wake cycle, sleep Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. got7fsn_ti up-regulation of circadian sleep/wake cycle, sleep|stimulation of circadian sleep/wake cycle, sleep|upregulation of circadian sleep/wake cycle, sleep|positive regulation of sleep|up regulation of circadian sleep/wake cycle, sleep|activation of circadian sleep/wake cycle, sleep biological_process owl:Class GO:0061103 biolink:NamedThing carotid body glomus cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia. got7fsn_ti dph 2010-04-28T10:59:24Z biological_process owl:Class GO:0061101 biolink:NamedThing neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. got7fsn_ti dph 2010-04-28T09:42:20Z biological_process owl:Class GO:0062036 biolink:NamedThing sensory perception of hot stimulus The series of events required for an organism to receive a hot temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. got7fsn_ti dph 2018-04-30T13:50:47Z biological_process owl:Class GO:0050955 biolink:NamedThing thermoception The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature). got7fsn_ti thermoreception Wikipedia:Thermoception biological_process owl:Class GO:0043273 biolink:NamedThing CTPase activity Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction. got7fsn_ti cytidine triphosphatase activity|CTPase activity, coupled|single-stranded DNA-dependent CTPase activity https://github.com/geneontology/go-ontology/issues/19078 dph 2015-11-11T13:05:32Z GO:0061747|GO:0061748 molecular_function owl:Class GO:0017111 biolink:NamedThing nucleoside-triphosphatase activity Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. got7fsn_ti nucleoside triphosphatase activity|nucleoside triphosphate phosphohydrolase activity|nucleoside 5-triphosphatase activity|nucleoside-5-triphosphate phosphohydrolase activity|unspecific diphosphate phosphohydrolase activity|NTPase activity|nucleoside triphosphate hydrolase activity|apyrase activity RHEA:23680|Reactome:R-HSA-8851089|Reactome:R-HSA-8850846|MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN|Reactome:R-HSA-8851110|Reactome:R-HSA-8851494|Reactome:R-HSA-8851538|Reactome:R-HSA-8851234 molecular_function owl:Class GO:0023021 biolink:NamedThing termination of signal transduction The signaling process in which signal transduction is brought to an end rather than being reversibly modulated. got7fsn_ti Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn. 2010-02-16T09:30:50Z biological_process owl:Class GO:0009968 biolink:NamedThing negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. got7fsn_ti inhibition of signal transduction|down regulation of signal transduction|negative regulation of signalling pathway|down-regulation of signal transduction|negative regulation of signaling pathway|downregulation of signal transduction GO:0035467 biological_process owl:Class GO:0102310 biolink:NamedThing dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) <=> dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-12940 molecular_function owl:Class GO:0016726 biolink:NamedThing oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. got7fsn_ti EC:1.17.1.- molecular_function owl:Class GO:0010646 biolink:NamedThing regulation of cell communication Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti biological_process owl:Class GO:0003430 biolink:NamedThing growth plate cartilage chondrocyte growth The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another. got7fsn_ti growth plate cartilage chondrocyte hypertrophy dph 2009-12-22T12:29:19Z biological_process owl:Class GO:0060560 biolink:NamedThing developmental growth involved in morphogenesis The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. got7fsn_ti differential growth dph 2009-04-28T08:42:53Z biological_process owl:Class GO:0051051 biolink:NamedThing negative regulation of transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti down-regulation of transport|down regulation of transport|inhibition of transport|downregulation of transport biological_process owl:Class GO:0000714 biolink:NamedThing meiotic strand displacement The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis. got7fsn_ti meiotic displacement loop processing|meiotic D-loop processing|meiotic D-loop dissociation|meiotic displacement loop dissociation biological_process owl:Class GO:0000732 biolink:NamedThing strand displacement The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. got7fsn_ti displacement loop dissociation|D-loop processing|displacement loop processing|D-loop dissociation biological_process owl:Class GO:0039520 biolink:NamedThing induction by virus of host autophagy Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host. got7fsn_ti positive regulation by virus of host autophagy|activation of host autophagy by virus bf 2011-06-22T04:24:47Z VZ:846 biological_process owl:Class GO:0039519 biolink:NamedThing modulation by virus of host autophagy Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host. got7fsn_ti regulation by virus of host autophagy bf 2011-06-22T04:19:19Z biological_process owl:Class GO:0002472 biolink:NamedThing macrophage antigen processing and presentation The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti biological_process owl:Class GO:0019882 biolink:NamedThing antigen processing and presentation The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti antigen presentation|antigen processing GO:0030333 Wikipedia:Antigen_presentation biological_process owl:Class GO:0010326 biolink:NamedThing methionine-oxo-acid transaminase activity Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid. got7fsn_ti MetaCyc:RXN-2201 molecular_function owl:Class GO:0046540 biolink:NamedThing U4/U6 x U5 tri-snRNP complex A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. got7fsn_ti U4/U6.U5 snRNP complex cellular_component owl:Class GO:0097526 biolink:NamedThing spliceosomal tri-snRNP complex A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP. got7fsn_ti pr 2013-10-18T15:58:47Z cellular_component owl:Class GO:0016256 biolink:NamedThing N-glycan processing to lysosome The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome. got7fsn_ti biological_process owl:Class GO:0006491 biolink:NamedThing N-glycan processing The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. got7fsn_ti N-linked glycoprotein maturation|glycoprotein trimming involved in glycoprotein maturation GO:0006492 biological_process owl:Class GO:0005937 biolink:NamedThing mating projection The projection formed by unicellular fungi in response to mating pheromone. got7fsn_ti conjugation tube|shmoo cellular_component owl:Class GO:0120025 biolink:NamedThing plasma membrane bounded cell projection A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. got7fsn_ti https://github.com/geneontology/go-ontology/issues/13193 krc 2017-03-21T17:26:07Z cellular_component owl:Class GO:0102599 biolink:NamedThing cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-beta-amyrin + H2O + NAD(P). got7fsn_ti MetaCyc:RXN-15383 molecular_function owl:Class GO:0035136 biolink:NamedThing forelimb morphogenesis The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. got7fsn_ti arm morphogenesis GO:0035140 biological_process owl:Class GO:0047238 biolink:NamedThing glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. got7fsn_ti UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyltransferase II activity|glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity|chondroitin synthase activity|UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Reactome:R-HSA-1971482|Reactome:R-HSA-9632033|Reactome:R-HSA-1971487|EC:2.4.1.175|Reactome:R-HSA-3595176|MetaCyc:2.4.1.175-RXN molecular_function owl:Class GO:0008376 biolink:NamedThing acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. got7fsn_ti GalNAc transferase activity Reactome:R-HSA-8931648|Reactome:R-HSA-8855954|Reactome:R-HSA-9605700 molecular_function owl:Class GO:0016615 biolink:NamedThing malate dehydrogenase activity Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. got7fsn_ti molecular_function owl:Class GO:0033539 biolink:NamedThing fatty acid beta-oxidation using acyl-CoA dehydrogenase A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti MetaCyc:FAO-PWY biological_process owl:Class GO:0006635 biolink:NamedThing fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti biological_process owl:Class GO:0033925 biolink:NamedThing mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. got7fsn_ti mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity|endo-beta-N-acetylglucosaminidase D activity|endo-beta-N-acetylglucosaminidase H activity|glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity|endo-beta-N-acetylglucosaminidase L activity|endo-N-acetyl-beta-glucosaminidase activity|endo-beta-N-acetylglucosaminidase activity|endo-N-acetyl-beta-D-glucosaminidase activity|mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity|endoglycosidase H activity|glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity|N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity|endo-beta-N-acetylglucosaminidase F activity|endoglycosidase S activity|endo-beta-(1->4)-N-acetylglucosaminidase activity|di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity|endo-beta-acetylglucosaminidase activity EC:3.2.1.96|MetaCyc:3.2.1.96-RXN|Reactome:R-HSA-8853379 molecular_function owl:Class GO:0010837 biolink:NamedThing regulation of keratinocyte proliferation Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class GO:0050678 biolink:NamedThing regulation of epithelial cell proliferation Any process that modulates the frequency, rate or extent of epithelial cell proliferation. got7fsn_ti biological_process owl:Class GO:0070056 biolink:NamedThing prospore membrane leading edge The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization. got7fsn_ti forespore membrane leading edge cellular_component owl:Class GO:0016020 biolink:NamedThing membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. got7fsn_ti region of membrane|whole membrane|membrane region 2014-03-06T11:37:54Z GO:0098589|GO:0098805 Wikipedia:Biological_membrane cellular_component owl:Class GO:0090697 biolink:NamedThing post-embryonic plant organ morphogenesis Morphogenesis, during the post-embryonic phase, of a plant tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti tb 2016-08-25T17:04:35Z biological_process owl:Class GO:0090698 biolink:NamedThing post-embryonic plant morphogenesis The process, occurring after plant embryonic development, by which anatomical structures are generated and organized. got7fsn_ti tb 2016-08-25T17:08:33Z biological_process owl:Class GO:0061826 biolink:NamedThing podosome ring The ring structure surrounding the podosome core, containing proteins such as vinculin and talin. got7fsn_ti dph 2017-01-14T14:44:53Z cellular_component owl:Class GO:0051449 biolink:NamedThing thyrotropin-releasing hormone binding Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system. got7fsn_ti thyrotropin releasing hormone binding molecular_function owl:Class GO:0017046 biolink:NamedThing peptide hormone binding Binding to a peptide with hormonal activity in animals. got7fsn_ti polypeptide hormone binding molecular_function owl:Class GO:0015347 biolink:NamedThing sodium-independent organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. got7fsn_ti Reactome:R-HSA-879594|Reactome:R-HSA-9661723|Reactome:R-HSA-9661397|Reactome:R-HSA-879562|Reactome:R-HSA-9661446|Reactome:R-HSA-561059|Reactome:R-HSA-879584|Reactome:R-HSA-9661799 molecular_function owl:Class GO:0008514 biolink:NamedThing organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. got7fsn_ti Reactome:R-HSA-2142859 molecular_function owl:Class GO:1900053 biolink:NamedThing negative regulation of retinoic acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process. got7fsn_ti downregulation of retinoic acid anabolic process|inhibition of retinoic acid biosynthetic process|down regulation of retinoic acid biosynthetic process|down-regulation of retinoic acid biosynthetic process|negative regulation of retinoic acid anabolic process|downregulation of retinoic acid biosynthetic process|down regulation of retinoic acid anabolic process|down-regulation of retinoic acid anabolic process|inhibition of retinoic acid anabolic process yaf 2012-01-20T09:55:49Z biological_process owl:Class GO:0046137 biolink:NamedThing negative regulation of vitamin metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. got7fsn_ti inhibition of vitamin metabolic process|down-regulation of vitamin metabolic process|down regulation of vitamin metabolic process|negative regulation of vitamin metabolism|downregulation of vitamin metabolic process biological_process owl:Class GO:0103071 biolink:NamedThing 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity Catalysis of the reaction: a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA <=> formyl-CoA + a 2-methyl branched 2,3,4-saturated fatty aldehyde. got7fsn_ti MetaCyc:RXN66-471 molecular_function owl:Class GO:0016830 biolink:NamedThing carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. got7fsn_ti other carbon-carbon lyase activity Reactome:R-HSA-389611|EC:4.1.-.- molecular_function owl:Class GO:0008649 biolink:NamedThing rRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. got7fsn_ti molecular_function owl:Class GO:0008173 biolink:NamedThing RNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. got7fsn_ti Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). Reactome:R-HSA-191784 molecular_function owl:Class GO:0008738 biolink:NamedThing L-fuculose-phosphate aldolase activity Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate. got7fsn_ti L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)|fuculose aldolase activity|L-fuculose 1-phosphate aldolase activity|L-fuculose-1-phosphate lactaldehyde-lyase activity MetaCyc:FUCPALDOL-RXN|RHEA:12933|EC:4.1.2.17|KEGG_REACTION:R02262 molecular_function owl:Class GO:0070976 biolink:NamedThing TIR domain binding Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. got7fsn_ti Toll-Interleukin receptor domain binding mah 2009-10-02T01:17:29Z molecular_function owl:Class GO:0047685 biolink:NamedThing amine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate. got7fsn_ti arylamine sulfotransferase activity|3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity|amine N-sulfotransferase activity|amine sulphotransferase activity EC:2.8.2.3|MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN|RHEA:24136 molecular_function owl:Class GO:0008146 biolink:NamedThing sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. got7fsn_ti sulphotransferase activity Reactome:R-HSA-2022061|EC:2.8.2.-|Reactome:R-HSA-176588|Reactome:R-HSA-176669|Reactome:R-HSA-176604 molecular_function owl:Class GO:0016213 biolink:NamedThing linoleoyl-CoA desaturase activity Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O. got7fsn_ti fatty acid delta6-desaturase activity|linoleoyl CoA desaturase activity|delta6-desaturase activity|linoleate desaturase activity|linoleic desaturase activity|long-chain fatty acid delta(6)-desaturase activity|fatty acid delta(6)-desaturase activity|delta(6)-fatty acyl-CoA desaturase activity|delta6-acyl CoA desaturase activity|delta6-fatty acyl-CoA desaturase activity|long-chain fatty acid delta6-desaturase activity|linoleoyl-coenzyme A desaturase activity|delta(6)-desaturase activity|linoleic acid desaturase activity|delta(6)-acyl CoA desaturase activity|fatty acid 6-desaturase activity Note that this function was formerly EC:1.14.99.25. Reactome:R-HSA-2046084|EC:1.14.19.3|Reactome:R-HSA-2046096|MetaCyc:1.14.19.3-RXN|RHEA:22196|Reactome:R-HSA-2046097|Reactome:R-HSA-2046099 molecular_function owl:Class GO:0016215 biolink:NamedThing acyl-CoA desaturase activity Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O. got7fsn_ti CoA desaturase activity https://github.com/geneontology/go-ontology/issues/21108 molecular_function owl:Class GO:0021680 biolink:NamedThing cerebellar Purkinje cell layer development The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. got7fsn_ti biological_process owl:Class GO:0009355 biolink:NamedThing DNA polymerase V complex A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis. got7fsn_ti cellular_component owl:Class GO:0042575 biolink:NamedThing DNA polymerase complex A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. got7fsn_ti cellular_component owl:Class GO:0031381 biolink:NamedThing viral RNA-directed RNA polymerase complex A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus. got7fsn_ti cellular_component owl:Class GO:0031379 biolink:NamedThing RNA-directed RNA polymerase complex A protein complex that possesses RNA-directed RNA polymerase activity. got7fsn_ti cellular_component owl:Class GO:0001634 biolink:NamedThing pituitary adenylate cyclase-activating polypeptide receptor activity A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide. got7fsn_ti pituitary adenylate cyclase-activating polypeptide receptor activity|pituitary adenylate cyclase activating polypeptide receptor|pituitary adenylate cyclase activating protein receptor activity|PACAP receptor|pituitary adenylate cyclase-activating peptide receptor activity|pituitary adenylyl cyclase activating protein receptor activity GO:0016522 molecular_function owl:Class GO:0004930 biolink:NamedThing G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti SREB receptor|G protein linked receptor activity|G-protein coupled receptor activity|orphan GPCR activity|G-protein linked receptor activity|RDC1 receptor activity|orphan G-protein coupled receptor activity|super conserved receptor expressed in brain receptor activity|Mas proto-oncogene receptor activity|Epstein-Barr Virus-induced receptor activity|ligand-dependent GPCR activity|G protein coupled receptor activity|EBV-induced receptor|GPCR activity|G-protein coupled receptor activity, unknown ligand|orphan G protein coupled receptor activity|receptor activity, G-protein coupled GO:0001625|GO:0001623|GO:0016526|GO:0001624|GO:0001622 Wikipedia:GPCR|Reactome:R-HSA-167408|Reactome:R-HSA-114558|Reactome:R-HSA-114552 molecular_function owl:Class GO:0042297 biolink:NamedThing vocal learning A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others. got7fsn_ti Examples include language learning by human infants and song learning in zebra finches. Wikipedia:Vocal_learning biological_process owl:Class GO:0031223 biolink:NamedThing auditory behavior The behavior of an organism in response to a sound. got7fsn_ti behavioural response to sound|behavioral response to sound|auditory behaviour biological_process owl:Class GO:0044741 biolink:NamedThing envenomation resulting in negative regulation of sensory perception of pain in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism. got7fsn_ti envenomation resulting in inhibition of sensory perception of pain in other organism jl 2012-11-07T14:02:14Z biological_process owl:Class GO:0044742 biolink:NamedThing envenomation resulting in modulation of sensory perception of pain in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism. got7fsn_ti envenomation resulting in regulation of sensory perception of pain in other organism jl 2012-11-07T14:26:38Z biological_process owl:Class GO:0090225 biolink:NamedThing regulation of spindle density Any process that modulates the number of microtubules in a given region of the spindle. got7fsn_ti tb 2010-01-13T11:24:53Z biological_process owl:Class GO:0090224 biolink:NamedThing regulation of spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. got7fsn_ti regulation of spindle organisation tb 2010-01-13T11:04:53Z biological_process owl:Class GO:0003419 biolink:NamedThing growth plate cartilage chondrocyte proliferation The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. got7fsn_ti dph 2009-12-22T09:02:51Z biological_process owl:Class GO:0008283 biolink:NamedThing cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. got7fsn_ti cell proliferation This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. biological_process owl:Class GO:0030445 biolink:NamedThing yeast-form cell wall The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form. got7fsn_ti See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'. cellular_component owl:Class GO:0009277 biolink:NamedThing fungal-type cell wall A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure. got7fsn_ti chitin-containing cell wall|beta-glucan-containing cell wall|chitin- and beta-glucan-containing cell wall cellular_component owl:Class GO:0051500 biolink:NamedThing D-tyrosyl-tRNA(Tyr) deacylase activity Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA. got7fsn_ti molecular_function owl:Class GO:0051499 biolink:NamedThing D-aminoacyl-tRNA deacylase activity Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA. got7fsn_ti EC:3.1.1.96|MetaCyc:RXN-15041|RHEA:13953 molecular_function owl:Class GO:0033592 biolink:NamedThing RNA strand annealing activity An activity that facilitates the formation of a complementary double-stranded RNA molecule. got7fsn_ti https://github.com/geneontology/go-ontology/issues/2161 molecular_function owl:Class GO:0003727 biolink:NamedThing single-stranded RNA binding Binding to single-stranded RNA. got7fsn_ti ssRNA binding GO:0003728 molecular_function owl:Class GO:0097668 biolink:NamedThing SCF-Saf1/Pof9 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe). got7fsn_ti pr 2014-10-06T10:28:30Z cellular_component owl:Class GO:0048136 biolink:NamedThing male germ-line cyst formation Formation of a group of interconnected cells derived from a single male gonial founder cell. got7fsn_ti male germline cyst formation biological_process owl:Class GO:0048134 biolink:NamedThing germ-line cyst formation Formation of a group of interconnected cells derived from a single gonial founder cell. got7fsn_ti germline cyst formation biological_process owl:Class GO:0015233 biolink:NamedThing pantothenate transmembrane transporter activity Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. got7fsn_ti vitamin B5 transmembrane transporter activity|pantothenate transporter activity molecular_function owl:Class GO:0090482 biolink:NamedThing vitamin transmembrane transporter activity Enables the transfer of a vitamin from one side of a membrane to the other. got7fsn_ti vitamin or cofactor transporter activity|vitamin transporter activity tb 2012-10-02T16:50:50Z GO:0051183 molecular_function owl:Class GO:0004342 biolink:NamedThing glucosamine-6-phosphate deaminase activity Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+). got7fsn_ti phosphoglucosaminisomerase activity|glucosaminephosphate isomerase|glucosamine-6-phosphate isomerase activity|phosphoglucosamine isomerase activity|aminodeoxyglucosephosphate isomerase activity|GlcN6P deaminase activity|2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)|glucosamine phosphate deaminase activity Note that this function was formerly EC:5.3.1.10. Reactome:R-HSA-6799604|MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN|RHEA:12172|EC:3.5.99.6|KEGG_REACTION:R00765 molecular_function owl:Class GO:0019239 biolink:NamedThing deaminase activity Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R). got7fsn_ti Reactome:R-HSA-9014641 molecular_function owl:Class GO:0043629 biolink:NamedThing ncRNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation. got7fsn_ti non-coding RNA polyadenylation biological_process owl:Class GO:0043631 biolink:NamedThing RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. got7fsn_ti biological_process owl:Class GO:0001974 biolink:NamedThing blood vessel remodeling The reorganization or renovation of existing blood vessels. got7fsn_ti biological_process owl:Class GO:0048771 biolink:NamedThing tissue remodeling The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. got7fsn_ti biological_process owl:Class GO:0008883 biolink:NamedThing glutamyl-tRNA reductase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH. got7fsn_ti L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming) EC:1.2.1.70|KEGG_REACTION:R04109|RHEA:12344|MetaCyc:GLUTRNAREDUCT-RXN molecular_function owl:Class GO:0140101 biolink:NamedThing catalytic activity, acting on a tRNA Catalytic activity that acts to modify a tRNA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-15T18:41:41Z molecular_function owl:Class GO:1902491 biolink:NamedThing negative regulation of sperm capacitation Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation. got7fsn_ti down regulation of sperm activation|negative regulation of sperm activation|downregulation of sperm capacitation|down-regulation of sperm capacitation|down regulation of sperm capacitation|inhibition of sperm activation|down-regulation of sperm activation|inhibition of sperm capacitation|downregulation of sperm activation hjd 2013-11-12T21:17:12Z biological_process owl:Class GO:1990530 biolink:NamedThing Cdc50p-Drs2p complex A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome. got7fsn_ti rb 2014-11-06T01:29:31Z cellular_component owl:Class GO:1990531 biolink:NamedThing phospholipid-translocating ATPase complex A protein complex that functions as a phospholipid-translocating P-Type ATPase. got7fsn_ti CRF1-DNF3 complex|phospholipid flippase complex|CDC50-DRS2 complex|DNF3-CRF1 complex|APLT complex|DRS2-CDC50 complex|Dnf1-Lem3 complex|aminophospholipid translocase complex|Dnf2-Lem3 complex|Lem3-Dnf1 complex|P4-ATPase complex|Lem3p-Dnf1p complex rb 2014-11-06T22:33:25Z cellular_component owl:Class GO:0047287 biolink:NamedThing lactosylceramide alpha-2,6-N-sialyltransferase activity Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP. got7fsn_ti CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity|CMP-sialic acid:lactosylceramide sialyltransferase activity|cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase|CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity|CMP-acetylneuraminate-lactosylceramide-sialyltransferase EC:2.4.99.11|MetaCyc:2.4.99.11-RXN|RHEA:21552 molecular_function owl:Class GO:0008373 biolink:NamedThing sialyltransferase activity Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. got7fsn_ti Reactome:R-HSA-9697018|Reactome:R-HSA-981814|Reactome:R-HSA-9683769|Reactome:R-HSA-9694718 molecular_function owl:Class GO:0061526 biolink:NamedThing acetylcholine secretion The regulated release of acetylcholine by a cell. got7fsn_ti dph 2013-06-21T15:40:39Z biological_process owl:Class GO:0003219 biolink:NamedThing cardiac right ventricle formation The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. got7fsn_ti dph 2009-10-13T09:55:38Z biological_process owl:Class GO:0003211 biolink:NamedThing cardiac ventricle formation The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. got7fsn_ti dph 2009-10-13T09:46:27Z biological_process owl:Class GO:0036343 biolink:NamedThing psychomotor behavior The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument. got7fsn_ti bf 2012-09-11T14:32:06Z biological_process owl:Class GO:0061744 biolink:NamedThing motor behavior The specific neuromuscular movement of a single organism in response to external or internal stimuli. got7fsn_ti dph 2015-11-09T12:43:11Z biological_process owl:Class GO:0050345 biolink:NamedThing trans-epoxysuccinate hydrolase activity Catalysis of the reaction: trans-2,3-epoxysuccinate + H(2)O = (2R,3S)-tartrate. got7fsn_ti tartrate epoxydase activity|trans-2,3-epoxysuccinate hydrolase activity|trans-epoxysuccinate hydratase activity RHEA:20740|EC:3.3.2.4|KEGG_REACTION:R02547|MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN molecular_function owl:Class GO:0016803 biolink:NamedThing ether hydrolase activity Catalysis of the hydrolysis of an ether bond, -O-. got7fsn_ti Reactome:R-HSA-8874435|EC:3.3.2.- molecular_function owl:Class GO:0046726 biolink:NamedThing positive regulation by virus of viral protein levels in host cell Any process where the infecting virus increases the levels of viral proteins in a cell. got7fsn_ti activation of viral protein levels in host cell|up regulation of viral protein levels in host cell|upregulation of viral protein levels in host cell|up-regulation of viral protein levels in host cell|positive regulation of viral protein levels|stimulation of viral protein levels in host cell biological_process owl:Class GO:0046719 biolink:NamedThing regulation by virus of viral protein levels in host cell Any virus-mediated process that modulates the levels of viral proteins in a cell. got7fsn_ti regulation of viral protein levels biological_process owl:Class GO:0008119 biolink:NamedThing thiopurine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. got7fsn_ti thiopurine methyltransferase activity|mercaptopurine methyltransferase activity|TPMT|6-thiopurine transmethylase activity|S-adenosyl-L-methionine:thiopurine S-methyltransferase activity Reactome:R-HSA-5603379|MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN|Reactome:R-HSA-158609|EC:2.1.1.67 molecular_function owl:Class GO:0008172 biolink:NamedThing S-methyltransferase activity Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. got7fsn_ti Reactome:R-HSA-209821|EC:2.1.1.- molecular_function owl:Class GO:0001548 biolink:NamedThing follicular fluid formation in ovarian follicle antrum The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis. got7fsn_ti ovarian follicle antrum/follicular fluid biosynthesis|ovarian follicle antrum/follicular fluid formation biological_process owl:Class GO:0022602 biolink:NamedThing ovulation cycle process A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. got7fsn_ti estrous cycle process|menstrual cycle process biological_process owl:Class GO:0008587 biolink:NamedThing imaginal disc-derived wing margin morphogenesis The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade. got7fsn_ti wing margin morphogenesis See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'. biological_process owl:Class GO:0046309 biolink:NamedThing 1,3-dichloro-2-propanol biosynthetic process The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. got7fsn_ti 1,3-dichloro-2-propanol biosynthesis|1,3-dichloro-2-propanol synthesis|1,3-dichloro-2-propanol anabolism|1,3-dichloro-2-propanol formation biological_process owl:Class GO:0033268 biolink:NamedThing node of Ranvier An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. got7fsn_ti node of Ranvier axon NIF_Subcellular:birnlex_1152_2|Wikipedia:Nodes_of_Ranvier cellular_component owl:Class GO:0010218 biolink:NamedThing response to far red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti response to far red light stimulus biological_process owl:Class GO:0030879 biolink:NamedThing mammary gland development The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. got7fsn_ti mammogenesis biological_process owl:Class GO:0031352 biolink:NamedThing intrinsic component of plastid inner membrane The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to plastid inner membrane cellular_component owl:Class GO:0031350 biolink:NamedThing intrinsic component of plastid membrane The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to plastid membrane cellular_component owl:Class GO:0035124 biolink:NamedThing embryonic caudal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion. got7fsn_ti biological_process owl:Class GO:0035143 biolink:NamedThing caudal fin morphogenesis The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion. got7fsn_ti biological_process owl:Class GO:0102978 biolink:NamedThing furaneol oxidoreductase activity Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP <=> 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+. got7fsn_ti EC:1.3.1.105|RHEA:39111|MetaCyc:RXN-9563 molecular_function owl:Class GO:0075510 biolink:NamedThing macropinocytosis involved in viral entry into host cell Any macropinocytosis that is involved in the uptake of a virus into a host cell. got7fsn_ti viral entry into host cell via macropinocytosis jl 2011-07-27T11:24:59Z VZ:800 biological_process owl:Class GO:0075509 biolink:NamedThing endocytosis involved in viral entry into host cell Any endocytosis that is involved in the uptake of a virus into a host cell. got7fsn_ti virus endocytosis by host|viral penetration via endocytosis followed by endosome disruption|viral entry into host cell via endocytosis jl 2011-07-27T11:06:34Z VZ:977 biological_process owl:Class GO:0050904 biolink:NamedThing diapedesis The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. got7fsn_ti Note that the term diapedesis, although sometimes used as a direct synonym for cellular extravasation, is used here for the specific final step of the process, in concordance with recent reviews of the topic. biological_process owl:Class GO:0050900 biolink:NamedThing leukocyte migration The movement of a leukocyte within or between different tissues and organs of the body. got7fsn_ti immune cell trafficking|leucocyte migration|leukocyte trafficking|leucocyte trafficking|immune cell migration biological_process owl:Class GO:0034983 biolink:NamedThing peptidyl-lysine deacetylation The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. got7fsn_ti protein lysine acetylation biological_process owl:Class GO:0034689 biolink:NamedThing integrin alphaX-beta2 complex An integrin complex that comprises one alphaX subunit and one beta2 subunit. got7fsn_ti alphaX-beta2 integrin complex|Itgax-Itgb2 complex cellular_component owl:Class GO:0008305 biolink:NamedThing integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. got7fsn_ti laminin receptor protein cellular_component owl:Class GO:0090174 biolink:NamedThing organelle membrane fusion The joining of two lipid bilayers to form a single organelle membrane. got7fsn_ti tb 2009-12-11T11:44:58Z biological_process owl:Class GO:0048284 biolink:NamedThing organelle fusion The creation of a single organelle from two or more organelles. got7fsn_ti biological_process owl:Class GO:0022608 biolink:NamedThing multicellular organism adhesion The attachment of a multicellular organism to a substrate or other organism. got7fsn_ti biological_process owl:Class GO:0032501 biolink:NamedThing multicellular organismal process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. got7fsn_ti single-multicellular organism process|organismal physiological process jl 2012-09-19T16:07:47Z GO:0050874|GO:0044707 biological_process owl:Class GO:0044392 biolink:NamedThing peptidyl-lysine malonylation The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine. got7fsn_ti lysine malonylation bf 2011-12-12T09:31:42Z RESID:AA0568 biological_process owl:Class GO:0044394 biolink:NamedThing protein malonylation The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group. got7fsn_ti bf 2011-12-12T09:26:37Z biological_process owl:Class GO:0102060 biolink:NamedThing endo-alpha-bergamotene synthase activity Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (-)-endo-alpha-bergamotene + diphosphoric acid. got7fsn_ti endo-alpha-bergamontene synthase activity RHEA:30471|MetaCyc:RXN-10482|EC:4.2.3.54 molecular_function owl:Class GO:0008033 biolink:NamedThing tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. got7fsn_ti tRNA maturation biological_process owl:Class GO:0006399 biolink:NamedThing tRNA metabolic process The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. got7fsn_ti tRNA metabolism biological_process owl:Class GO:0046810 biolink:NamedThing host cell extracellular matrix binding Binding to the extracellular matrix of a host cell. got7fsn_ti molecular_function owl:Class GO:0050840 biolink:NamedThing extracellular matrix binding Binding to a component of the extracellular matrix. got7fsn_ti adhesive extracellular matrix constituent|extracellular matrix constituent binding molecular_function owl:Class GO:0003953 biolink:NamedThing NAD+ nucleosidase activity Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. got7fsn_ti NAD nucleosidase activity Reactome:R-HSA-8938076|Reactome:R-HSA-8870346|RHEA:16301 molecular_function owl:Class GO:0016799 biolink:NamedThing hydrolase activity, hydrolyzing N-glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond. got7fsn_ti EC:3.2.2.- molecular_function owl:Class GO:0042015 biolink:NamedThing interleukin-20 binding Binding to interleukin-20. got7fsn_ti IL-20 binding molecular_function owl:Class GO:0019955 biolink:NamedThing cytokine binding Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. got7fsn_ti interleukin binding|IL binding GO:0019965 molecular_function owl:Class GO:0005594 biolink:NamedThing collagen type IX trimer A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils. got7fsn_ti cellular_component owl:Class GO:0005593 biolink:NamedThing FACIT collagen trimer A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences. got7fsn_ti The acronym FACIT stands for fibril-associated collagen with interrupted triple helix. Wikipedia:FACIT_collagen cellular_component owl:Class GO:0046786 biolink:NamedThing viral replication complex formation and maintenance The process of organizing and assembling viral replication proteins in preparation for viral replication. got7fsn_ti biological_process owl:Class GO:0097400 biolink:NamedThing interleukin-17-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-17 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-17-mediated signalling pathway|IL-17-mediated signalling pathway|IL-17-mediated signaling pathway pr 2012-10-23T13:30:03Z biological_process owl:Class GO:0019221 biolink:NamedThing cytokine-mediated signaling pathway A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti cytokine mediated signalling pathway|cytokine and chemokine mediated signaling pathway biological_process owl:Class GO:0043291 biolink:NamedThing RAVE complex A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme. got7fsn_ti regulator of the (H+)-ATPase of the vacuolar and endosomal membranes cellular_component owl:Class GO:0061263 biolink:NamedThing mesonephric glomerular mesangial cell development The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure. got7fsn_ti dph 2010-08-30T02:52:55Z biological_process owl:Class GO:0072144 biolink:NamedThing glomerular mesangial cell development The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure. got7fsn_ti mah 2010-02-24T01:53:13Z biological_process owl:Class GO:0071788 biolink:NamedThing endoplasmic reticulum tubular network maintenance The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section. got7fsn_ti ER tubular network maintenance mah 2010-09-01T01:55:06Z biological_process owl:Class GO:0043954 biolink:NamedThing cellular component maintenance The organization process that preserves a cellular component in a stable functional or structural state. got7fsn_ti cellular component maintenance at cellular level GO:0071956 biological_process owl:Class GO:0018733 biolink:NamedThing 3,4-dihydrocoumarin hydrolase activity Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate. got7fsn_ti UM-BBD_reactionID:r0419|EC:3.1.1.35 molecular_function owl:Class GO:0043027 biolink:NamedThing cysteine-type endopeptidase inhibitor activity involved in apoptotic process Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. got7fsn_ti caspase inhibitor activity molecular_function owl:Class GO:0043028 biolink:NamedThing cysteine-type endopeptidase regulator activity involved in apoptotic process Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. got7fsn_ti caspase regulator activity molecular_function owl:Class GO:0050708 biolink:NamedThing regulation of protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. got7fsn_ti biological_process owl:Class GO:0051223 biolink:NamedThing regulation of protein transport Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class GO:0050778 biolink:NamedThing positive regulation of immune response Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. got7fsn_ti upregulation of immune response|stimulation of immune response|up-regulation of immune response|up regulation of immune response biological_process owl:Class GO:0050776 biolink:NamedThing regulation of immune response Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. got7fsn_ti biological_process owl:Class GO:0034667 biolink:NamedThing integrin alpha3-beta1 complex An integrin complex that comprises one alpha3 subunit and one beta1 subunit. got7fsn_ti VLA-3 complex|alpha3-beta1 integrin complex|ITGA3-ITGB1 complex cellular_component owl:Class GO:0007602 biolink:NamedThing phototransduction The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. got7fsn_ti phototrophin mediated phototransduction|opsin|phototransduction, visible light, light adaptation Wikipedia:Visual_phototransduction biological_process owl:Class GO:0007165 biolink:NamedThing signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. got7fsn_ti signal transduction by cis-phosphorylation|signalling pathway|signalling cascade|signal transduction by protein phosphorylation|signaling cascade|signal transduction by trans-phosphorylation|signal transduction by conformational transition|signaling pathway Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. GO:0023015|GO:0023045|GO:0023014|GO:0023033|GO:0023016 Wikipedia:Signal_transduction biological_process owl:Class GO:0061709 biolink:NamedThing reticulophagy The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. got7fsn_ti autophagy of the endoplasmic reticulum|endoplasmic reticulum degradation|ER-phagy|ER degradation|autophagy of the ER|endoplasmic reticulum autophagy|ER autophagy dph 2015-06-18T15:15:48Z GO:1990766 biological_process owl:Class GO:1903008 biolink:NamedThing organelle disassembly The disaggregation of an organelle into its constituent components. got7fsn_ti organelle degradation jl 2014-05-13T12:36:03Z biological_process owl:Class GO:0032985 biolink:NamedThing protein-carbohydrate complex disassembly The disaggregation of a protein-carbohydrate complex into its constituent components. got7fsn_ti biological_process owl:Class GO:0071823 biolink:NamedThing protein-carbohydrate complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex. got7fsn_ti protein-carbohydrate complex subunit organisation mah 2010-09-08T10:03:03Z biological_process owl:Class GO:0043326 biolink:NamedThing chemotaxis to folate The directed movement of a motile cell or organism in response to the presence of folate. got7fsn_ti biological_process owl:Class GO:0006935 biolink:NamedThing chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti taxis in response to chemical stimulus Wikipedia:Chemotaxis biological_process owl:Class GO:0000269 biolink:NamedThing toxin export channel activity Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. got7fsn_ti molecular_function owl:Class GO:0075239 biolink:NamedThing zoospore formation The process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. got7fsn_ti biological_process owl:Class GO:0033012 biolink:NamedThing porosome A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles. got7fsn_ti Wikipedia:Porosome cellular_component owl:Class GO:0008986 biolink:NamedThing pyruvate, water dikinase activity Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate. got7fsn_ti phosphopyruvate synthetase activity|pyruvate-water dikinase (phosphorylating)|pyruvate,water dikinase activity|water pyruvate dikinase activity|ATP:pyruvate, water phosphotransferase activity|phoephoenolpyruvate synthetase activity|PEP synthase activity|phosphoenolpyruvic synthase activity|phosphoenolpyruvate synthase activity|PEP synthetase activity MetaCyc:PEPSYNTH-RXN|RHEA:11364|EC:2.7.9.2|KEGG_REACTION:R00199 molecular_function owl:Class GO:0016301 biolink:NamedThing kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. got7fsn_ti phosphokinase activity Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. Reactome:R-HSA-6788855|Reactome:R-HSA-6788867 molecular_function owl:Class GO:0003875 biolink:NamedThing ADP-ribosylarginine hydrolase activity Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose. got7fsn_ti ADPribosylarginine hydrolase activity|ADP-ribose-L-arginine cleaving enzyme activity|ADP-ribose-L-arginine cleavage enzyme activity|protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity|nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity|omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity|protein ADP-ribosylarginine hydrolase activity|N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity RHEA:20784|EC:3.2.2.19|MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN molecular_function owl:Class GO:0061756 biolink:NamedThing leukocyte adhesion to vascular endothelial cell The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. got7fsn_ti dph 2016-02-29T16:42:11Z biological_process owl:Class GO:0007159 biolink:NamedThing leukocyte cell-cell adhesion The attachment of a leukocyte to another cell via adhesion molecules. got7fsn_ti leukocyte cell adhesion|leukocyte adhesion biological_process owl:Class GO:0004877 biolink:NamedThing complement component C3b receptor activity Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class GO:0004875 biolink:NamedThing complement receptor activity Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti anaphylatoxin receptor activity Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. GO:0004942 molecular_function owl:Class GO:0048006 biolink:NamedThing antigen processing and presentation, endogenous lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. got7fsn_ti antigen presentation, endogenous lipid antigen|endogenous lipid antigen processing and presentation via MHC class Ib biological_process owl:Class GO:0048003 biolink:NamedThing antigen processing and presentation of lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. got7fsn_ti lipid antigen processing and presentation via MHC class Ib|antigen presentation, lipid antigen biological_process owl:Class GO:0048614 biolink:NamedThing post-embryonic ectodermal digestive tract morphogenesis The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. got7fsn_ti post-embryonic ectodermal gut morphogenesis biological_process owl:Class GO:0045496 biolink:NamedThing male analia development The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class GO:0007487 biolink:NamedThing analia development The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster. got7fsn_ti biological_process owl:Class GO:0043114 biolink:NamedThing regulation of vascular permeability Any process that modulates the extent to which blood vessels can be pervaded by fluid. got7fsn_ti biological_process owl:Class GO:0003018 biolink:NamedThing vascular process in circulatory system A circulatory process that occurs at the level of the vasculature. got7fsn_ti vasculature process biological_process owl:Class GO:0070978 biolink:NamedThing voltage-gated calcium channel complex assembly Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex. got7fsn_ti mah 2009-10-06T04:51:13Z biological_process owl:Class GO:0034622 biolink:NamedThing cellular protein-containing complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. got7fsn_ti cellular macromolecule complex assembly|cellular protein complex assembly GO:0043623 biological_process owl:Class GO:0034558 biolink:NamedThing technetium (VII) reductase activity Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-. got7fsn_ti UM-BBD_reactionID:r0859 molecular_function owl:Class GO:0016695 biolink:NamedThing oxidoreductase activity, acting on hydrogen as donor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor. got7fsn_ti oxidoreductase activity, acting on hydrogen as donor, other acceptors EC:1.12.-.- molecular_function owl:Class GO:0051844 biolink:NamedThing translocation of peptides or proteins into symbiont The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti transport of peptides or proteins into symbiont biological_process owl:Class GO:0051862 biolink:NamedThing translocation of molecules into symbiont The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti transport of molecules into symbiont biological_process owl:Class GO:0099004 biolink:NamedThing calmodulin dependent kinase signaling pathway Any signal transduction pathway involving calmodulin dependent kinase activity. got7fsn_ti CAMK signaling pathway biological_process owl:Class GO:0102817 biolink:NamedThing caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA <=> gentiodelphin + coenzyme A. got7fsn_ti MetaCyc:RXN-8235 molecular_function owl:Class GO:0051747 biolink:NamedThing cytosine C-5 DNA demethylase activity Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA. got7fsn_ti DNA methyltransferase activity acting on cytosine C-5|DNA demethylase activity|hydrolytic DNA demethylase activity molecular_function owl:Class GO:0140097 biolink:NamedThing catalytic activity, acting on DNA Catalytic activity that acts to modify DNA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-14T12:03:51Z molecular_function owl:Class GO:0009589 biolink:NamedThing detection of UV The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. got7fsn_ti perception of UV|detection of ultraviolet light stimulus|detection of ultraviolet radiation stimulus|detection of UV radiation stimulus|detection of UV light stimulus biological_process owl:Class GO:0009411 biolink:NamedThing response to UV Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. got7fsn_ti response to ultraviolet light stimulus|response to UV radiation stimulus|response to ultraviolet radiation stimulus|response to UV light stimulus biological_process owl:Class GO:1990385 biolink:NamedThing meiotic spindle midzone The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap. got7fsn_ti kmv 2014-05-29T20:52:44Z cellular_component owl:Class GO:0051233 biolink:NamedThing spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap. got7fsn_ti spindle equator|central spindle cellular_component owl:Class GO:0061627 biolink:NamedThing S-methylmethionine-homocysteine S-methyltransferase activity Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+. got7fsn_ti homocysteine transmethylase activity|methylmethionine:homocysteine methyltransferase activity|S-methylmethionine homocysteine transmethylase activity|homocysteine methyltransferase activity dph 2014-05-14T14:32:02Z Reactome:R-HSA-5696838|RHEA:26337 molecular_function owl:Class GO:0031463 biolink:NamedThing Cul3-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. got7fsn_ti CDL3 complex|BCR3 complex|cullin-RING ligase 3|BC3B complex|CRL3 complex|SCF3 complex cellular_component owl:Class GO:0031461 biolink:NamedThing cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. got7fsn_ti CRL complex|cullin complex|cullin-RING ligase cellular_component owl:Class GO:0072376 biolink:NamedThing protein activation cascade A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events. got7fsn_ti protein activitory cascade|protein activation pathway mah 2010-11-22T02:54:18Z biological_process owl:Class GO:0019538 biolink:NamedThing protein metabolic process The chemical reactions and pathways involving a protein. Includes protein modification. got7fsn_ti protein metabolic process and modification|protein metabolism|protein metabolism and modification|multicellular organismal protein metabolic process GO:0006411|GO:0044268 Wikipedia:Protein_metabolism biological_process owl:Class GO:0075137 biolink:NamedThing response to host redox environment Any process that results in a change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response of symbiont to host redox environment Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class GO:0075136 biolink:NamedThing response to host Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response of symbiont to host Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class GO:0102040 biolink:NamedThing fumarate reductase (menaquinone) Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone. got7fsn_ti EC:1.3.5.4|MetaCyc:R601-RXN|RHEA:27834 molecular_function owl:Class GO:0016635 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound. got7fsn_ti EC:1.3.5.- molecular_function owl:Class GO:0080041 biolink:NamedThing ADP-ribose pyrophosphohydrolase activity Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate. got7fsn_ti molecular_function owl:Class GO:0019144 biolink:NamedThing ADP-sugar diphosphatase activity Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate. got7fsn_ti ADP-sugar pyrophosphatase activity|ADP-sugar sugarphosphohydrolase activity|nucleoside diphosphate-sugar hydrolase activity|adenosine diphosphosugar pyrophosphatase activity|ADPsugar pyrophosphatase activity EC:3.6.1.21|MetaCyc:ADPSUGPPHOSPHAT-RXN molecular_function owl:Class GO:1990334 biolink:NamedThing Bfa1-Bub2 complex A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation. got7fsn_ti bhm 2014-03-17T14:34:21Z cellular_component owl:Class GO:1902773 biolink:NamedThing GTPase activator complex A protein complex which is capable of GTPase activator activity. got7fsn_ti An example of this is BFA1 in Saccharomyces cerevisiae (P47113) in PMID:16449187 (inferred from direct assay). bhm 2014-03-17T14:26:08Z cellular_component owl:Class GO:0035233 biolink:NamedThing germ cell repulsion The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue. got7fsn_ti biological_process owl:Class GO:0060326 biolink:NamedThing cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti biological_process owl:Class GO:0007588 biolink:NamedThing excretion The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. got7fsn_ti Wikipedia:Excretion biological_process owl:Class GO:0003008 biolink:NamedThing system process A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. got7fsn_ti organ system process biological_process owl:Class GO:0004465 biolink:NamedThing lipoprotein lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. got7fsn_ti postheparin esterase activity|clearing factor lipase activity|postheparin lipase activity|lipemia-clearing factor|diacylglycerol lipase activity|diglyceride lipase activity|triacylglycero-protein acylhydrolase activity|diacylglycerol hydrolase activity EC:3.1.1.34|Reactome:R-HSA-174757|Reactome:R-HSA-8979996|Reactome:R-HSA-1482811|Reactome:R-HSA-6789310|Reactome:R-HSA-2395768|MetaCyc:LIPOPROTEIN-LIPASE-RXN|Reactome:R-HSA-8980228 molecular_function owl:Class GO:0004806 biolink:NamedThing triglyceride lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. got7fsn_ti triglyceridase activity|glycerol ester hydrolase activity|amano B|triacylglycerol ester hydrolase activity|tween-hydrolyzing esterase activity|tweenesterase activity|amno N-AP|triacylglycerol acylhydrolase activity|tweenase activity|salt-resistant post-heparin lipase|triolein hydrolase activity|triglyceride hydrolase activity|hepatic monoacylglycerol acyltransferase|amano P|triacylglycerol lipase activity|amano CE|meito MY 30|GA 56|butyrinase activity|GEH|takedo 1969-4-9|tributyrinase activity|amano AP|meito sangyo OF lipase|capalase L|glycerol-ester hydrolase activity|amano CES|tributyrin esterase activity|tributyrase activity|liver lipase|TAG activity|post-heparin plasma protamine-resistant lipase|steapsin|tween hydrolase activity|PPL|lipazin|hepatic lipase|cacordase activity|triacetinase activity|heparin releasable hepatic lipase Reactome:R-HSA-8848339|Reactome:R-HSA-1482777|Reactome:R-HSA-8848338|Reactome:R-HSA-163551|RHEA:12044|EC:3.1.1.3|MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN|Reactome:R-HSA-5694109 molecular_function owl:Class GO:0060086 biolink:NamedThing circadian temperature homeostasis Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours. got7fsn_ti circadian thermoregulation|circadian regulation of body temperature biological_process owl:Class GO:0001659 biolink:NamedThing temperature homeostasis A homeostatic process in which an organism modulates its internal body temperature. got7fsn_ti thermoregulation Wikipedia:Thermoregulation biological_process owl:Class GO:0120230 biolink:NamedThing recombinase activator activity Binds to and increases the activity of a recombinase. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19631|https://github.com/geneontology/go-ontology/issues/19555 krc 2020-06-18T15:54:26Z molecular_function owl:Class GO:0008047 biolink:NamedThing enzyme activator activity Binds to and increases the activity of an enzyme. got7fsn_ti metalloenzyme activator activity This term should only be used in cases when the regulator directly interacts with the enzyme. GO:0010577 molecular_function owl:Class GO:0021856 biolink:NamedThing hypothalamic tangential migration using cell-axon interactions The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons. got7fsn_ti biological_process owl:Class GO:0021855 biolink:NamedThing hypothalamus cell migration The directed movement of a cell into the hypothalamus region of the forebrain. got7fsn_ti biological_process owl:Class GO:0010850 biolink:NamedThing regulation of blood pressure by chemoreceptor signaling pathway A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. got7fsn_ti regulation of blood pressure by chemoreceptor signalling pathway biological_process owl:Class GO:0008217 biolink:NamedThing regulation of blood pressure Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. got7fsn_ti control of blood pressure|blood pressure regulation|blood pressure homeostasis Wikipedia:Blood_pressure#Regulation biological_process owl:Class GO:0031322 biolink:NamedThing ascospore-type prospore-specific spindle pole body remodeling A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP). got7fsn_ti forespore specific spindle pole body remodeling|ascospore-type prospore-specific spindle pole body remodelling|prospore-specific spindle pole body remodeling|forespore-specific spindle pole body remodeling|sporulation-specific spindle pole body remodeling|ascospore-type prospore-specific spindle pole body modification biological_process owl:Class GO:0106358 biolink:NamedThing glycerol-1-phosphate dehydrogenase [NADP+] activity Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH. got7fsn_ti hjd 2021-02-02T06:08:14Z RHEA:21416 molecular_function owl:Class GO:0050492 biolink:NamedThing glycerol-1-phosphate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate. got7fsn_ti sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity EC:1.1.1.261|MetaCyc:1.1.1.261-RXN molecular_function owl:Class GO:0033825 biolink:NamedThing oligosaccharide 4-alpha-D-glucosyltransferase activity Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides. got7fsn_ti amylase III activity|1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity|1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity EC:2.4.1.161|MetaCyc:2.4.1.161-RXN molecular_function owl:Class GO:0046664 biolink:NamedThing dorsal closure, amnioserosa morphology change The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo. got7fsn_ti biological_process owl:Class GO:0048729 biolink:NamedThing tissue morphogenesis The process in which the anatomical structures of a tissue are generated and organized. got7fsn_ti biological_process owl:Class GO:1903431 biolink:NamedThing positive regulation of cell maturation Any process that activates or increases the frequency, rate or extent of cell maturation. got7fsn_ti up regulation of functional differentiation|positive regulation of functional differentiation|upregulation of functional differentiation|upregulation of cell maturation|activation of functional differentiation|activation of cell maturation|up-regulation of cell maturation|up regulation of cell maturation|up-regulation of functional differentiation jl 2014-09-15T13:31:41Z biological_process owl:Class GO:0010720 biolink:NamedThing positive regulation of cell development Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti biological_process owl:Class GO:1990484 biolink:NamedThing aerobic lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen. got7fsn_ti aerobic lactic acid catabolic process tt 2014-09-20T05:42:51Z biological_process owl:Class GO:1903457 biolink:NamedThing lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate. got7fsn_ti lactate catabolism|lactate degradation|lactate breakdown pr 2014-09-23T08:41:03Z biological_process owl:Class GO:0044562 biolink:NamedThing envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism. got7fsn_ti jl 2012-04-05T04:01:49Z biological_process owl:Class GO:0044559 biolink:NamedThing envenomation resulting in modulation of voltage-gated potassium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism. got7fsn_ti jl 2012-04-05T03:35:20Z biological_process owl:Class GO:0009720 biolink:NamedThing detection of hormone stimulus The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of hormone stimulus biological_process owl:Class GO:0009725 biolink:NamedThing response to hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. got7fsn_ti response to hormone stimulus|growth regulator biological_process owl:Class GO:0070529 biolink:NamedThing L-tryptophan aminotransferase activity Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid. got7fsn_ti molecular_function owl:Class GO:0051015 biolink:NamedThing actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. got7fsn_ti F-actin binding|actin cross-linking activity molecular_function owl:Class GO:0003779 biolink:NamedThing actin binding Binding to monomeric or multimeric forms of actin, including actin filaments. got7fsn_ti membrane associated actin binding molecular_function owl:Class GO:0042795 biolink:NamedThing snRNA transcription by RNA polymerase II The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter. got7fsn_ti snRNA transcription from RNA polymerase II promoter|snRNA transcription from Pol II promoter https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class GO:0006366 biolink:NamedThing transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). got7fsn_ti specific transcription from RNA polymerase II promoter|transcription from Pol II promoter|transcription from RNA polymerase II promoter|gene-specific transcription from RNA polymerase II promoter|general transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity https://github.com/geneontology/go-ontology/issues/14854 GO:0032568|GO:0032569 biological_process owl:Class GO:0050878 biolink:NamedThing regulation of body fluid levels Any process that modulates the levels of body fluids. got7fsn_ti biological_process owl:Class GO:0001791 biolink:NamedThing IgM binding Binding to an immunoglobulin of the IgM isotype. got7fsn_ti molecular_function owl:Class GO:0019865 biolink:NamedThing immunoglobulin binding Binding to an immunoglobulin. got7fsn_ti molecular_function owl:Class GO:0075526 biolink:NamedThing cap snatching A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs. got7fsn_ti cap snatching involved in viral mRNA transcription jl 2011-08-04T01:19:00Z VZ:839 biological_process owl:Class GO:0075221 biolink:NamedThing negative regulation of zoospore encystment on host Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class GO:0075219 biolink:NamedThing modulation of zoospore encystment on host Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class GO:0016416 biolink:NamedThing O-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule. got7fsn_ti Reactome:R-HSA-2466710|Reactome:R-HSA-2453855|Reactome:R-HSA-2404137 molecular_function owl:Class GO:0008374 biolink:NamedThing O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. got7fsn_ti Reactome:R-HSA-1482867|Reactome:R-HSA-1482850|Reactome:R-HSA-5483229|Reactome:R-HSA-1482781|Reactome:R-HSA-1482775|Reactome:R-HSA-162683|Reactome:R-HSA-422017|Reactome:R-HSA-5358343|Reactome:R-HSA-3238694|Reactome:R-HSA-422104|Reactome:R-HSA-1482861 molecular_function owl:Class GO:0140084 biolink:NamedThing sexual macrocyst formation The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum. got7fsn_ti macrocyst formation|sexual fusion pg 2017-08-14T20:11:03Z biological_process owl:Class GO:0019953 biolink:NamedThing sexual reproduction A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. got7fsn_ti Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. Wikipedia:Sexual_reproduction biological_process owl:Class GO:0021890 biolink:NamedThing olfactory bulb interneuron fate commitment The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb. got7fsn_ti biological_process owl:Class GO:0048663 biolink:NamedThing neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. got7fsn_ti neuronal lineage restriction|neuron lineage restriction GO:0042055 biological_process owl:Class GO:0005622 biolink:NamedThing intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. got7fsn_ti intracellular|internal to cell|nucleocytoplasm|protoplasm|protoplast https://github.com/geneontology/go-ontology/issues/17776 Wikipedia:Intracellular cellular_component owl:Class GO:0003262 biolink:NamedThing endocardial progenitor cell migration to the midline involved in heart field formation The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart. got7fsn_ti dph 2009-10-15T02:00:41Z biological_process owl:Class GO:0060975 biolink:NamedThing cardioblast migration to the midline involved in heart field formation The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti cardioblast midline convergence|cardiac progenitor cell midline migration dph 2009-10-06T10:59:36Z biological_process owl:Class GO:0010316 biolink:NamedThing pyrophosphate-dependent phosphofructokinase complex Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate. got7fsn_ti PFK complex cellular_component owl:Class GO:0061660 biolink:NamedThing Atg12 ligase activity Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S --> X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T13:50:42Z molecular_function owl:Class GO:0061659 biolink:NamedThing ubiquitin-like protein ligase activity Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3|small conjugating protein ligase activity dph 2014-11-06T13:46:23Z molecular_function owl:Class GO:0106370 biolink:NamedThing protein-L-histidine N-pros-methyltransferase activity Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine. got7fsn_ti hjd 2021-03-22T15:13:06Z RHEA:67076 molecular_function owl:Class GO:0008757 biolink:NamedThing S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. got7fsn_ti SAM-dependent methyltransferase activity|S-adenosyl methionine-dependent methyltransferase activity molecular_function owl:Class GO:0071356 biolink:NamedThing cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. got7fsn_ti cellular response to TNF mah 2009-12-11T02:51:37Z biological_process owl:Class GO:0034612 biolink:NamedThing response to tumor necrosis factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. got7fsn_ti response to TNF biological_process owl:Class GO:0043488 biolink:NamedThing regulation of mRNA stability Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. got7fsn_ti biological_process owl:Class GO:0043487 biolink:NamedThing regulation of RNA stability Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. got7fsn_ti biological_process owl:Class GO:0048343 biolink:NamedThing paraxial mesodermal cell fate commitment The process in which a cell becomes committed to become a paraxial mesoderm cell. got7fsn_ti biological_process owl:Class GO:0001710 biolink:NamedThing mesodermal cell fate commitment The cell differentiation process that results in commitment of a cell to become part of the mesoderm. got7fsn_ti mesoderm cell fate commitment biological_process owl:Class GO:0120174 biolink:NamedThing stress-induced homeostatically regulated protein degradation pathway A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway. got7fsn_ti SHRED pathway Note, although the SHRED pathway may contain some components in common with ER-associated protein degradation (ERAD) pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10 do not appear to be involved, and as such these pathways are currently considered to be distinct. ERAD pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M) and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by subsequent substrate ubiquitination and proteosome-mediated degradation. In contrast the SHRED pathway, although inducible by stress, targets diverse ER membrane and cytosolic proteins as well as numerous other native proteins in the absence of stress. In the SHRED pathway an Nma111p serine protease-mediated cleavage results in the generation of a Roq1p fragment that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. SHRED is also considered to be distinct from the endoplasmic reticulum unfolded protein response (GO:0030968), a process by which ER stress activates the ER membrane protein Ire1p, resulting in splicing of the HAC1 mRNA, followed by Hac1p-mediated up-regulation of UPR genes. Induction of SHRED does not require IRE1 or HAC1, and as such is currently considered to be distinct. krc 2018-06-07T16:16:43Z biological_process owl:Class GO:0033554 biolink:NamedThing cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0005252 biolink:NamedThing open rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration. got7fsn_ti molecular_function owl:Class GO:0005249 biolink:NamedThing voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-sensitive potassium channel|voltage-dependent potassium channel activity|voltage gated potassium channel activity|voltage-gated potassium ion channel activity Reactome:R-HSA-1296127 molecular_function owl:Class GO:0051877 biolink:NamedThing pigment granule aggregation in cell center The directed movement of dispersed pigment granules towards the center of the cell. got7fsn_ti biological_process owl:Class GO:0051905 biolink:NamedThing establishment of pigment granule localization The directed movement of a pigment granule to a specific location. got7fsn_ti establishment of pigment granule localisation biological_process owl:Class GO:0102275 biolink:NamedThing cysteine-S-conjugate N-malonyl transferase activity Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate <=> coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate. got7fsn_ti MetaCyc:RXN-12534 molecular_function owl:Class GO:0003401 biolink:NamedThing axis elongation The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. got7fsn_ti elongation of an axis dph 2009-12-21T01:12:15Z biological_process owl:Class GO:0047485 biolink:NamedThing protein N-terminus binding Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. got7fsn_ti amino-terminus binding|NH2-terminus binding|N-terminal binding|NH2-terminal binding|N-terminal end binding|amino-terminal binding molecular_function owl:Class GO:0005515 biolink:NamedThing protein binding Binding to a protein. got7fsn_ti protein amino acid binding|glycoprotein binding GO:0045308|GO:0001948 molecular_function owl:Class GO:0140582 biolink:NamedThing adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway A series of molecular signals initiated by cAMP binding to its receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. got7fsn_ti extracellular cAMP signaling pathway https://github.com/geneontology/go-ontology/issues/20487 pg 2021-01-18T19:30:30Z biological_process owl:Class GO:0007189 biolink:NamedThing adenylate cyclase-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). got7fsn_ti positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|positive regulation of adenylate cyclase activity by G-protein signalling pathway|G-protein signalling, adenylate cyclase activating pathway|G-protein signaling, adenylate cyclase activating pathway|G protein signalling, adenylate cyclase activating pathway|G protein signaling, adenylate cyclase activating pathway|GPCR signaling pathway via activation of adenylate cyclase|G-protein signaling, adenylyl cyclase activating pathway|G protein signalling, adenylyl cyclase activating pathway|G protein signaling, adenylyl cyclase activating pathway|activation of adenylate cyclase activity by G-protein signaling pathway|GPCR signaling pathway via activation of adenylate cyclase activity|adenylate cyclase-activating GPCR signaling pathway|activation of adenylate cyclase activity involved in G-protein signaling|positive regulation of adenylate cyclase activity by G-protein signaling pathway|G-protein signalling, adenylyl cyclase activating pathway This term can be used to annotate ligands, receptors and G-proteins that lead to activation of adenylate cyclase activity within a signaling pathway. GO:0010579|GO:0010580 biological_process owl:Class GO:0071595 biolink:NamedThing Nem1-Spo7 phosphatase complex A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p. got7fsn_ti mah 2010-01-29T02:17:29Z cellular_component owl:Class GO:0033802 biolink:NamedThing isoliquiritigenin 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity|chalcone OMT|CHMT KEGG_REACTION:R07242|RHEA:21608|MetaCyc:RXN-3501|EC:2.1.1.154 molecular_function owl:Class GO:0061201 biolink:NamedThing clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen The volume enclosed by the membrane of the clathrin-sculpted gamma-aminobutyric acid transport vesicle. got7fsn_ti clathrin sculpted gamma-aminobutyric acid transport vesicle lumen|clathrin sculpted GABA transport vesicle lumen dph 2010-07-29T10:45:05Z cellular_component owl:Class GO:0060205 biolink:NamedThing cytoplasmic vesicle lumen The volume enclosed by a cytoplasmic vesicle. got7fsn_ti cytoplasmic membrane-enclosed vesicle lumen|cytoplasmic membrane-bounded vesicle lumen cellular_component owl:Class GO:0048256 biolink:NamedThing flap endonuclease activity Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. got7fsn_ti molecular_function owl:Class GO:0004520 biolink:NamedThing endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. got7fsn_ti endonuclease G activity|DNA nicking activity Reactome:R-HSA-5690988|Reactome:R-HSA-6782224|Reactome:R-HSA-5693608|Reactome:R-HSA-5687464|Reactome:R-HSA-110359|Reactome:R-HSA-5686657|Reactome:R-HSA-6782204|Reactome:R-HSA-5693584|Reactome:R-HSA-5686440|Reactome:R-HSA-9023941 molecular_function owl:Class GO:0031261 biolink:NamedThing DNA replication preinitiation complex A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. got7fsn_ti pre-IC cellular_component owl:Class GO:0032993 biolink:NamedThing protein-DNA complex A macromolecular complex containing both protein and DNA molecules. got7fsn_ti DNA-protein complex Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. cellular_component owl:Class GO:0044736 biolink:NamedThing acid-sensing ion channel activity Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex. got7fsn_ti ASIC activity jl 2012-11-06T16:36:37Z Reactome:R-HSA-2671885|Wikipedia:Acid-sensing_ion_channel molecular_function owl:Class GO:0015280 biolink:NamedThing ligand-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti ASIC activity|epithelial sodium channel|amiloride-sensitive sodium channel activity|acid-sensing ion channel activity Reactome:R-HSA-2672334 molecular_function owl:Class GO:0003423 biolink:NamedThing growth plate cartilage chondrocyte division The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate. got7fsn_ti dph 2009-12-22T09:55:51Z biological_process owl:Class GO:0051301 biolink:NamedThing cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. got7fsn_ti Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. Wikipedia:Cell_division biological_process owl:Class GO:0042073 biolink:NamedThing intraciliary transport The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. got7fsn_ti intraflagellar transport involved in cilium organization|IFT|intraflagellar transport involved in microtubule-based flagellum organisation|intraflagellar transport Note that we deem cilium and microtubule-based flagellum to be equivalent. GO:0035734 Wikipedia:Intraflagellar_transport biological_process owl:Class GO:0010970 biolink:NamedThing transport along microtubule The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. got7fsn_ti movement along microtubule|establishment of localization by movement along microtubule|microtubule-based transport tb 2009-05-27T10:56:08Z biological_process owl:Class GO:0061388 biolink:NamedThing regulation of rate of cell growth Any process that modulates the rate of cell growth. got7fsn_ti dph 2011-07-14T10:18:06Z biological_process owl:Class GO:0001558 biolink:NamedThing regulation of cell growth Any process that modulates the frequency, rate, extent or direction of cell growth. got7fsn_ti biological_process owl:Class GO:0072663 biolink:NamedThing establishment of protein localization to peroxisome The directed movement of a protein to a specific location in a peroxisome. got7fsn_ti establishment of protein localisation to peroxisome mah 2011-02-14T02:50:36Z biological_process owl:Class GO:0072594 biolink:NamedThing establishment of protein localization to organelle The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. got7fsn_ti establishment of protein localisation to organelle mah 2011-02-14T01:56:51Z biological_process owl:Class GO:0031578 biolink:NamedThing mitotic spindle orientation checkpoint signaling A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected. got7fsn_ti SPOC|signal transduction involved in mitotic cell cycle spindle orientation checkpoint|SOC|mitotic cell cycle spindle orientation checkpoint|spindle position checkpoint|mitotic spindle orientation checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072483 biological_process owl:Class GO:0001100 biolink:NamedThing negative regulation of exit from mitosis Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). got7fsn_ti downregulation of exit from mitosis|down regulation of exit from mitosis|inhibition of exit from mitosis|down-regulation of exit from mitosis biological_process owl:Class GO:0106335 biolink:NamedThing tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity Catalysis of the reaction: carboxymethyluridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine. got7fsn_ti hjd 2020-10-27T21:34:30Z RHEA:43208|EC:2.1.1.229 molecular_function owl:Class GO:0060718 biolink:NamedThing chorionic trophoblast cell differentiation The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer. got7fsn_ti dph 2009-06-11T02:48:27Z biological_process owl:Class GO:0030381 biolink:NamedThing chorion-containing eggshell pattern formation The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects. got7fsn_ti biological_process owl:Class GO:0034752 biolink:NamedThing cytosolic aryl hydrocarbon receptor complex An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP. got7fsn_ti cytosolic AhR complex|cytosolic AHRC|9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex cellular_component owl:Class GO:0034751 biolink:NamedThing aryl hydrocarbon receptor complex A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR. got7fsn_ti AhR complex|AHRC cellular_component owl:Class GO:0005024 biolink:NamedThing transforming growth factor beta-activated receptor activity Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. got7fsn_ti TGFbeta-activated receptor activity|TGF-beta receptor activity|transforming growth factor beta receptor activity|TGFbeta receptor activity|TGFbetaR Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand TGFbeta. For binding to other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class GO:0004675 biolink:NamedThing transmembrane receptor protein serine/threonine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. got7fsn_ti receptor protein serine/threonine kinase activity|receptor serine/threonine protein kinase activity EC:2.7.11.30|Reactome:R-HSA-198732|Reactome:R-HSA-170868|Reactome:R-HSA-201476|MetaCyc:2.7.11.30-RXN|RHEA:18673 molecular_function owl:Class GO:0047563 biolink:NamedThing 3-hydroxybenzoate 2-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O(2) = 2,3-dihydroxybenzoate + A + H(2)O. got7fsn_ti 3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)|3-hydroxybenzoate 2-hydroxylase activity|3-HBA-2-hydroxylase activity KEGG_REACTION:R01508|RHEA:14193|MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN|EC:1.14.99.23 molecular_function owl:Class GO:0031051 biolink:NamedThing scnRNA processing Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome. got7fsn_ti scnRNA production biological_process owl:Class GO:0031050 biolink:NamedThing dsRNA processing Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. got7fsn_ti dsRNA fragmentation|double-stranded RNA fragmentation biological_process owl:Class GO:0019133 biolink:NamedThing choline monooxygenase activity Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O. got7fsn_ti choline,reduced-ferredoxin:oxygen oxidoreductase activity RHEA:17769|EC:1.14.15.7|MetaCyc:RXN1F-357 molecular_function owl:Class GO:0016713 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. got7fsn_ti oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen EC:1.14.15.- molecular_function owl:Class GO:0031776 biolink:NamedThing melanin-concentrating hormone receptor binding Binding to a melanin-concentrating hormone receptor. got7fsn_ti melanin-concentrating hormone receptor ligand molecular_function owl:Class GO:0071855 biolink:NamedThing neuropeptide receptor binding Binding to a neuropeptide receptor. got7fsn_ti mah 2010-09-10T03:21:43Z molecular_function owl:Class GO:0002774 biolink:NamedThing Fc receptor mediated inhibitory signaling pathway A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. got7fsn_ti Fc-receptor mediated inhibitory signaling pathway|Fc receptor mediated inhibitory signalling pathway biological_process owl:Class GO:0002767 biolink:NamedThing immune response-inhibiting cell surface receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response. got7fsn_ti immune response-inhibiting cell surface receptor signalling pathway biological_process owl:Class GO:0032797 biolink:NamedThing SMN complex A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. got7fsn_ti survival motor neuron complex|SMN core complex Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'. cellular_component owl:Class GO:0120114 biolink:NamedThing Sm-like protein family complex A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles. got7fsn_ti krc 2017-11-06T18:46:43Z cellular_component owl:Class GO:0046960 biolink:NamedThing sensitization An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched. got7fsn_ti Wikipedia:Sensitization biological_process owl:Class GO:0046958 biolink:NamedThing nonassociative learning A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment. got7fsn_ti unconditional response biological_process owl:Class GO:0140511 biolink:NamedThing mitotic nuclear bridge stalk Either of the regions of a mitotic nuclear bridge proximal to the main portion of each daughter nucleus. The nuclear envelope in the stalk regions is depleted of nuclear pore complexes. got7fsn_ti pg 2020-09-07T10:06:23Z cellular_component owl:Class GO:0016667 biolink:NamedThing oxidoreductase activity, acting on a sulfur group of donors Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on sulfur group of donors, other acceptors|oxidoreductase activity, acting on sulphur group of donors EC:1.8.-.-|Reactome:R-HSA-2213240 molecular_function owl:Class GO:0097531 biolink:NamedThing mast cell migration The movement of a mast cell within or between different tissues and organs of the body. got7fsn_ti pr 2013-11-11T14:01:41Z biological_process owl:Class GO:0097529 biolink:NamedThing myeloid leukocyte migration The movement of a myeloid leukocyte within or between different tissues and organs of the body. got7fsn_ti pr 2013-11-11T13:59:43Z biological_process owl:Class GO:0047623 biolink:NamedThing adenosine-phosphate deaminase activity Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP. got7fsn_ti adenosine-phosphate aminohydrolase activity|adenine nucleotide deaminase activity|adenosine (phosphate) deaminase activity Consider instead annotating to one of the more specific terms: AMP deaminase activity ; GO:0003876, ADP deaminase activity ; GO:0047629, or ATP deaminase activity ; GO:0047692. MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN|EC:3.5.4.17 molecular_function owl:Class GO:0016814 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. got7fsn_ti EC:3.5.4.- molecular_function owl:Class GO:0047827 biolink:NamedThing D-lysopine dehydrogenase activity Catalysis of the reaction: D-lysopine + H(2)O + NADP(+) = L-lysine + H(+) + NADPH + pyruvate. got7fsn_ti 2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|lysopine dehydrogenase activity|D(+)-lysopine dehydrogenase activity|D-lysopine synthase activity RHEA:17625|EC:1.5.1.16|KEGG_REACTION:R00452|MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN molecular_function owl:Class GO:0016646 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti EC:1.5.1.- molecular_function owl:Class GO:0002144 biolink:NamedThing cytosolic tRNA wobble base thiouridylase complex A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets. got7fsn_ti tRNA thiouridylase|Cut1-Cut2 complex hjd 2009-05-08T02:32:55Z cellular_component owl:Class GO:0030217 biolink:NamedThing T cell differentiation The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. got7fsn_ti T cell development|T lymphocyte differentiation|T-lymphocyte differentiation|T-cell differentiation Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. GO:0042112|GO:0046652 biological_process owl:Class GO:0042110 biolink:NamedThing T cell activation The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti T-cell activation|T-lymphocyte activation|T lymphocyte activation biological_process owl:Class GO:0072119 biolink:NamedThing head kidney structural organization The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. got7fsn_ti head kidney structural organisation mah 2010-02-22T11:22:12Z biological_process owl:Class GO:0072118 biolink:NamedThing pronephros structural organization The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. got7fsn_ti pronephric kidney structural organization|pronephros structural organisation mah 2010-02-22T11:21:38Z biological_process owl:Class GO:0045701 biolink:NamedThing negative regulation of spermatid nuclear differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation. got7fsn_ti inhibition of spermatid nuclear differentiation|down-regulation of spermatid nuclear differentiation|down regulation of spermatid nuclear differentiation|downregulation of spermatid nuclear differentiation biological_process owl:Class GO:0045596 biolink:NamedThing negative regulation of cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. got7fsn_ti down regulation of cell differentiation|downregulation of cell differentiation|down-regulation of cell differentiation|inhibition of cell differentiation biological_process owl:Class GO:0002209 biolink:NamedThing behavioral defense response A behavioral response seeking to protect an organism from an a perceived external threat to that organism. got7fsn_ti behavioural defense response biological_process owl:Class GO:0006952 biolink:NamedThing defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. got7fsn_ti defense/immunity protein activity|defence response|antimicrobial peptide activity|physiological defense response GO:0002217|GO:0042829 biological_process owl:Class GO:0022013 biolink:NamedThing pallium cell proliferation in forebrain The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population. got7fsn_ti biological_process owl:Class GO:0021846 biolink:NamedThing cell proliferation in forebrain The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. got7fsn_ti biological_process owl:Class GO:0018292 biolink:NamedThing molybdenum incorporation via L-cysteinyl molybdopterin The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin. got7fsn_ti RESID:AA0142 biological_process owl:Class GO:0018315 biolink:NamedThing molybdenum incorporation into molybdenum-molybdopterin complex The incorporation of molybdenum into a molybdenum-molybdopterin complex. got7fsn_ti molybdenum incorporation into metallo-pterin complex GO:0042041 biological_process owl:Class GO:0004750 biolink:NamedThing ribulose-phosphate 3-epimerase activity Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. got7fsn_ti erythrose-4-phosphate isomerase activity|ribulose 5-phosphate 3-epimerase activity|pentose-5-phosphate 3-epimerase activity|D-ribulose-5-P 3-epimerase activity|D-xylulose-5-phosphate 3-epimerase activity|xylulose phosphate 3-epimerase activity|D-ribulose-5-phosphate epimerase activity|erythrose-4-phosphate epimerase activity|phosphoketopentose 3-epimerase activity|D-ribulose phosphate-3-epimerase activity|D-ribulose 5-phosphate epimerase activity|phosphoketopentose epimerase activity|D-ribulose-5-phosphate 3-epimerase activity|phosphoribulose epimerase activity Reactome:R-HSA-71303|Reactome:R-HSA-199803|KEGG_REACTION:R01529|RHEA:13677|MetaCyc:RIBULP3EPIM-RXN|EC:5.1.3.1 molecular_function owl:Class GO:0016857 biolink:NamedThing racemase and epimerase activity, acting on carbohydrates and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. got7fsn_ti Reactome:R-HSA-6787677|EC:5.1.3.- molecular_function owl:Class GO:0015024 biolink:NamedThing glucuronate-2-sulfatase activity Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. got7fsn_ti glucurono-2-sulfatase activity|polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity|glucuronate-2-sulphatase activity|chondro-2-sulfatase activity MetaCyc:3.1.6.18-RXN|EC:3.1.6.18 molecular_function owl:Class GO:0008484 biolink:NamedThing sulfuric ester hydrolase activity Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. got7fsn_ti sulfatase activity|sulphuric ester hydrolase activity MetaCyc:ARYLSULFAT-RXN|EC:3.1.6.- molecular_function owl:Class GO:0042447 biolink:NamedThing hormone catabolic process The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. got7fsn_ti hormone breakdown|hormone catabolism|hormone degradation biological_process owl:Class GO:0034115 biolink:NamedThing negative regulation of heterotypic cell-cell adhesion Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion. got7fsn_ti biological_process owl:Class GO:0070587 biolink:NamedThing regulation of cell-cell adhesion involved in gastrulation Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation. got7fsn_ti mah 2009-04-24T02:51:07Z biological_process owl:Class GO:0047995 biolink:NamedThing hydroxyphenylpyruvate reductase activity Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH. got7fsn_ti HPRP|4-hydroxyphenyllactate:NAD+ oxidoreductase activity EC:1.1.1.237|RHEA:10780|MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN molecular_function owl:Class GO:0044649 biolink:NamedThing envenomation resulting in cytolysis in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with cytolysis in the bitten organism. got7fsn_ti jl 2012-07-11T02:13:38Z biological_process owl:Class GO:0047676 biolink:NamedThing arachidonate-CoA ligase activity Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). got7fsn_ti arachidonate:CoA ligase (AMP-forming)|arachidonoyl-CoA synthetase activity RHEA:19713|MetaCyc:ARACHIDONATE--COA-LIGASE-RXN|KEGG_REACTION:R01598|EC:6.2.1.15 molecular_function owl:Class GO:0016405 biolink:NamedThing CoA-ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. got7fsn_ti Reactome:R-HSA-177157|Reactome:R-HSA-159443|Reactome:R-HSA-6798345|Reactome:R-HSA-159567 molecular_function owl:Class GO:0075313 biolink:NamedThing basidium development The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi. got7fsn_ti Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked. biological_process owl:Class GO:0075259 biolink:NamedThing spore-bearing structure development The process whose specific outcome is the progression of a spore-bearing structure over time, from its formation to the mature structure. A spore-bearing structure is an anatomical structure that produces new spores. got7fsn_ti sporangium development|sporophore development|fruiting structure development|spore-bearing organ development biological_process owl:Class GO:0005146 biolink:NamedThing leukemia inhibitory factor receptor binding Binding to an leukemia inhibitory factor receptor. got7fsn_ti leukemia inhibitory factor|leukemia inhibitory factor receptor ligand molecular_function owl:Class GO:0005126 biolink:NamedThing cytokine receptor binding Binding to a cytokine receptor. got7fsn_ti hematopoietin/interferon-class (D200-domain) cytokine receptor binding|hematopoietin/interferon-class (D200-domain) cytokine receptor ligand molecular_function owl:Class GO:0036313 biolink:NamedThing phosphatidylinositol 3-kinase catalytic subunit binding Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. got7fsn_ti p110 binding|PI3K catalytic subunit binding bf 2012-08-16T10:58:45Z molecular_function owl:Class GO:0009757 biolink:NamedThing hexose mediated signaling A series of molecular signals mediated by the detection of hexose. got7fsn_ti hexose mediated signalling biological_process owl:Class GO:0010182 biolink:NamedThing sugar mediated signaling pathway The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes. got7fsn_ti sugar mediated signalling biological_process owl:Class GO:0018069 biolink:NamedThing peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase. got7fsn_ti RESID:AA0149 biological_process owl:Class GO:0018149 biolink:NamedThing peptide cross-linking The formation of a covalent cross-link between or within protein chains. got7fsn_ti biological_process owl:Class GO:0048653 biolink:NamedThing anther development The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class GO:0034214 biolink:NamedThing protein hexamerization The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits. got7fsn_ti protein hexamer biosynthesis|protein hexamer assembly|protein hexamer biosynthetic process|protein hexamer formation biological_process owl:Class GO:0051259 biolink:NamedThing protein complex oligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. got7fsn_ti protein oligomer biosynthesis|protein multimerization|protein oligomer formation|protein oligomer biosynthetic process|protein oligomer assembly|protein oligomerization bf 2011-04-05T09:57:49Z GO:0035786 biological_process owl:Class GO:0051220 biolink:NamedThing cytoplasmic sequestering of protein The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. got7fsn_ti storage of protein in cytoplasm|maintenance of protein location in cytoplasm|cytoplasmic storage of protein|retention of protein in cytoplasm|sequestration of protein in cytoplasm|cytoplasmic retention of protein|cytoplasmic sequestration of protein|sequestering of protein in cytoplasm biological_process owl:Class GO:0045185 biolink:NamedThing maintenance of protein location Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away. got7fsn_ti protein retention|protein sequestering|maintenance of protein localization|active protein retrieval biological_process owl:Class GO:0102553 biolink:NamedThing lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein) Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. got7fsn_ti EC:2.8.1.8|MetaCyc:RXN-14957 molecular_function owl:Class GO:0031323 biolink:NamedThing regulation of cellular metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. got7fsn_ti regulation of cellular metabolism biological_process owl:Class GO:0009570 biolink:NamedThing chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. got7fsn_ti cellular_component owl:Class GO:0009532 biolink:NamedThing plastid stroma The proteinaceous ground substance of plastids. got7fsn_ti cellular_component owl:Class GO:0061291 biolink:NamedThing canonical Wnt signaling pathway involved in ureteric bud branching The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. got7fsn_ti canonical Wnt receptor signalling pathway involved in ureteric bud branching|canonical Wnt receptor signaling pathway involved in ureteric bud branching dph 2010-09-03T12:15:19Z biological_process owl:Class GO:0061290 biolink:NamedThing canonical Wnt signaling pathway involved in metanephric kidney development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. got7fsn_ti canonical Wnt receptor signaling pathway involved in metanephric kidney development|canonical Wnt-activated signaling pathway involved in metanephric kidney development|canonical Wnt receptor signalling pathway involved in metanephric kidney development dph 2010-09-03T12:06:10Z biological_process owl:Class GO:0033874 biolink:NamedThing scymnol sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H(+). got7fsn_ti RHEA:15477|EC:2.8.2.32|KEGG_REACTION:R07798|MetaCyc:2.8.2.32-RXN molecular_function owl:Class GO:0019105 biolink:NamedThing N-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class GO:0042311 biolink:NamedThing vasodilation An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. got7fsn_ti positive regulation of blood vessel size|vasodilatation https://github.com/geneontology/go-ontology/issues/12253 GO:0045909 Wikipedia:Vasodilation biological_process owl:Class GO:0097746 biolink:NamedThing blood vessel diameter maintenance Any process that modulates the diameter of blood vessels. got7fsn_ti regulation of vasodilation|blood vessel diameter homeostasis|regulation of blood vessel diameter|regulation of vasodilatation|regulation of blood vessel size https://github.com/geneontology/go-ontology/issues/12253 pr 2016-11-24T15:45:05Z GO:0042312|GO:0050880 biological_process owl:Class GO:0008106 biolink:NamedThing alcohol dehydrogenase (NADP+) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. got7fsn_ti NADP-aldehyde reductase activity|alcohol:NADP dehydrogenase activity|aldehyde reductase (NADPH) activity|aldehyde reductase (NADPH2) activity MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN|RHEA:15937|EC:1.1.1.2 molecular_function owl:Class GO:0004033 biolink:NamedThing aldo-keto reductase (NADP) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. got7fsn_ti aldo-keto reductase activity|aldo-keto reductase (NADP+) activity|NADPH-dependent aldo-keto reductase activity|alcohol dehydrogenase (NADP+) activity Reactome:R-HSA-193800|Reactome:R-HSA-5692232|Reactome:R-HSA-193821|Reactome:R-HSA-9027598|Reactome:R-HSA-9027531|Reactome:R-HSA-5423637|Reactome:R-HSA-192067|Reactome:R-HSA-9027600|Reactome:R-HSA-193746|Reactome:R-HSA-192033|Reactome:R-HSA-193781|Reactome:R-HSA-192160|Reactome:R-HSA-193758|Reactome:R-HSA-2855252|Reactome:R-HSA-192036|Reactome:R-HSA-193755|Reactome:R-HSA-193824|Reactome:R-HSA-193841|Reactome:R-HSA-198845|Reactome:R-HSA-9027562 molecular_function owl:Class GO:0038196 biolink:NamedThing type III interferon signaling pathway A series of molecular signals initiated by the binding of a type III interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far. got7fsn_ti interferon lambda signaling pathway|type III interferon-activated signaling pathway bf 2013-11-27T14:25:49Z biological_process owl:Class GO:0048513 biolink:NamedThing animal organ development Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti development of an organ|organogenesis Wikipedia:Organogenesis biological_process owl:Class GO:0097493 biolink:NamedThing structural molecule activity conferring elasticity The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling. got7fsn_ti pr 2013-07-26T09:47:26Z molecular_function owl:Class GO:0005198 biolink:NamedThing structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. got7fsn_ti molecular_function owl:Class GO:0000804 biolink:NamedThing W chromosome The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females. got7fsn_ti Wikipedia:ZW_sex-determination_system cellular_component owl:Class GO:0070456 biolink:NamedThing galactose-1-phosphate phosphatase activity Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate. got7fsn_ti molecular_function owl:Class GO:0050308 biolink:NamedThing sugar-phosphatase activity Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. got7fsn_ti sugar-phosphate phosphohydrolase activity|sugar-phosphate phosphatase activity MetaCyc:SUGAR-PHOSPHATASE-RXN|KEGG_REACTION:R00804|EC:3.1.3.23 molecular_function owl:Class GO:0071559 biolink:NamedThing response to transforming growth factor beta Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. got7fsn_ti response to TGF-beta stimulus|response to TGFbeta stimulus|response to transforming growth factor beta stimulus mah 2010-01-20T11:49:59Z biological_process owl:Class GO:0005684 biolink:NamedThing U2-type spliceosomal complex Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. got7fsn_ti GT-AG spliceosome|major spliceosomal complex|major (U2-type) spliceosomal complex A U2-type complex refers to any of the snRNP-based complexes that form during splicing that uses U2 (as opposed to U12). There are complexes that form during U2-splicing that don't necessarily contain the U2 snRNP. cellular_component owl:Class GO:0005681 biolink:NamedThing spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. got7fsn_ti spliceosome complex|spliceosome Wikipedia:Spliceosome cellular_component owl:Class GO:0002128 biolink:NamedThing tRNA nucleoside ribose methylation The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position. got7fsn_ti biological_process owl:Class GO:0030488 biolink:NamedThing tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. got7fsn_ti biological_process owl:Class GO:0004508 biolink:NamedThing steroid 17-alpha-monooxygenase activity Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. got7fsn_ti steroid 17alpha-hydroxylase activity|cytochrome P450 CYP17|steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)|steroid 17-alpha-hydroxylase activity|steroid 17alpha-monooxygenase activity|17alpha-hydroxylase-C17,20 lyase activity|steroid 17-alpha-hydroxylase/17,20 lyase activity|cytochrome p450 XVIIA1 activity|cytochrome P45017alpha|steroid 17-alpha-hydroxylase-C17-20 lyase activity|steroid 17alphahydroxylase/17,20 lyase activity|cytochrome P-450 (P-45017alpha,lyase) Reactome:R-HSA-193072|Reactome:R-HSA-193099|MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN|Reactome:R-HSA-9035954|Reactome:R-HSA-5601843|Reactome:R-HSA-193070|Reactome:R-HSA-193068|EC:1.14.14.19|Reactome:R-HSA-9035956 molecular_function owl:Class GO:0008395 biolink:NamedThing steroid hydroxylase activity Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. got7fsn_ti cytochrome P450 CYP2G1|olfactory-specific steroid hydroxylase activity GO:0008394 Reactome:R-HSA-193060|Reactome:R-HSA-6785245|Reactome:R-HSA-193497|Reactome:R-HSA-193965|Reactome:R-HSA-193713|Reactome:R-HSA-193460|Reactome:R-HSA-5602170|Reactome:R-HSA-193393|Reactome:R-HSA-5601849|Reactome:R-HSA-192042|Reactome:R-HSA-193737|Reactome:R-HSA-6785244|Reactome:R-HSA-192123|Reactome:R-HSA-193780|Reactome:R-HSA-192054|Reactome:R-HSA-193995|RHEA:43836|Reactome:R-HSA-193787|Reactome:R-HSA-191999|Reactome:R-HSA-9035960|Reactome:R-HSA-193143|Reactome:R-HSA-193719|Reactome:R-HSA-193792|Reactome:R-HSA-191983 molecular_function owl:Class GO:0097632 biolink:NamedThing extrinsic component of phagophore assembly site membrane The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to phagophore assembly site membrane|extrinsic component of pre-autophagosomal structure membrane|phagophore assembly site peripheral membrane cellular_component owl:Class GO:0031312 biolink:NamedThing extrinsic component of organelle membrane The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to organelle membrane cellular_component owl:Class GO:0006955 biolink:NamedThing immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. got7fsn_ti biological_process owl:Class GO:0050961 biolink:NamedThing detection of temperature stimulus involved in sensory perception The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. got7fsn_ti sensory detection of temperature stimulus|sensory perception, sensory transduction of heat stimulus|sensory perception, sensory detection of thermal stimulus|sensory perception, sensory transduction of temperature stimulus|sensory transduction of temperature stimulus|sensory detection of heat stimulus during sensory perception|sensory perception, sensory detection of heat stimulus|sensory transduction of thermal stimulus during sensory perception|sensory detection of thermal stimulus during sensory perception|sensory transduction of temperature stimulus during sensory perception|sensory transduction of heat stimulus during sensory perception|sensory detection of temperature stimulus during sensory perception|sensory perception, sensory detection of temperature stimulus|sensory perception, sensory transduction of thermal stimulus biological_process owl:Class GO:0050906 biolink:NamedThing detection of stimulus involved in sensory perception The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. got7fsn_ti sensory perception, sensory transduction of stimulus|sensory detection of stimulus|sensory perception, stimulus detection|sensory transduction Wikipedia:Transduction_(physiology) biological_process owl:Class GO:0061223 biolink:NamedThing mesonephric mesenchymal cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state. got7fsn_ti dph 2010-08-19T01:21:48Z biological_process owl:Class GO:0061208 biolink:NamedThing cell differentiation involved in mesonephros development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state. got7fsn_ti dph 2010-08-17T03:21:23Z biological_process owl:Class GO:0061198 biolink:NamedThing fungiform papilla formation The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue. got7fsn_ti dph 2010-07-27T12:29:03Z biological_process owl:Class GO:0048871 biolink:NamedThing multicellular organismal homeostasis Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. got7fsn_ti biological_process owl:Class GO:0042592 biolink:NamedThing homeostatic process Any biological process involved in the maintenance of an internal steady state. got7fsn_ti homeostasis|regulation of homeostatic process|positive regulation of homeostatic process|negative regulation of homeostatic process|inhibition of homeostatic process|activation of homeostatic process GO:0032846|GO:0032844|GO:0032845 biological_process owl:Class GO:0010366 biolink:NamedThing negative regulation of ethylene biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process. got7fsn_ti biological_process owl:Class GO:0031336 biolink:NamedThing negative regulation of sulfur amino acid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. got7fsn_ti down-regulation of sulfur amino acid metabolic process|downregulation of sulfur amino acid metabolic process|negative regulation of sulfur amino acid metabolism|down regulation of sulfur amino acid metabolic process|inhibition of sulfur amino acid metabolic process biological_process owl:Class GO:0017042 biolink:NamedThing glycosylceramidase activity Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. got7fsn_ti phloretin-glucosidase activity|lactase-phlorizin hydrolase|cerebrosidase activity|phlorizin hydrolase activity|glycosyl-N-acylsphingosine glycohydrolase activity|phloridzin glucosidase activity|phloridzin beta-glucosidase activity|glycosyl ceramide glycosylhydrolase activity EC:3.2.1.62|MetaCyc:GLYCOSYLCERAMIDASE-RXN molecular_function owl:Class GO:0060454 biolink:NamedThing positive regulation of gastric acid secretion Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. got7fsn_ti biological_process owl:Class GO:0061355 biolink:NamedThing Wnt protein secretion The controlled release of a Wnt protein from a cell. got7fsn_ti dph 2010-10-08T01:07:48Z biological_process owl:Class GO:0009306 biolink:NamedThing protein secretion The controlled release of proteins from a cell. got7fsn_ti protein secretion resulting in cell fate commitment|glycoprotein secretion|protein secretion during cell fate commitment GO:0045731|GO:0045166 biological_process owl:Class GO:1990185 biolink:NamedThing regulation of lymphatic vascular permeability Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid. got7fsn_ti sl 2013-09-11T15:36:22Z biological_process owl:Class GO:2000874 biolink:NamedThing regulation of glyoxylate cycle Any process that modulates the frequency, rate or extent of glyoxylate cycle. got7fsn_ti regulation of glyoxylate bypass bf 2011-07-27T01:27:10Z biological_process owl:Class GO:0050519 biolink:NamedThing holo-citrate lyase synthase activity Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase. got7fsn_ti CitX|2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity|2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity|2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity|holo-ACP synthase activity RHEA:16333|MetaCyc:2.7.7.61-RXN|EC:2.7.7.61 molecular_function owl:Class GO:0016779 biolink:NamedThing nucleotidyltransferase activity Catalysis of the transfer of a nucleotidyl group to a reactant. got7fsn_ti Reactome:R-HSA-6782434|EC:2.7.7.- molecular_function owl:Class GO:1990883 biolink:NamedThing rRNA cytidine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA. got7fsn_ti al 2015-10-28T13:27:35Z molecular_function owl:Class GO:0008080 biolink:NamedThing N-acetyltransferase activity Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. got7fsn_ti Reactome:R-HSA-2473152|Reactome:R-HSA-9636560|Reactome:R-HSA-6790987|Reactome:R-HSA-2468039 molecular_function owl:Class GO:0009896 biolink:NamedThing positive regulation of catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. got7fsn_ti positive regulation of breakdown|activation of catabolic process|stimulation of catabolic process|up regulation of catabolic process|positive regulation of catabolism|up-regulation of catabolic process|positive regulation of degradation|upregulation of catabolic process biological_process owl:Class GO:0009893 biolink:NamedThing positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. got7fsn_ti up-regulation of organismal metabolic process|positive regulation of multicellular organismal metabolic process|positive regulation of organismal metabolism|activation of metabolic process|stimulation of organismal metabolic process|upregulation of metabolic process|positive regulation of metabolism|up-regulation of metabolic process|up regulation of metabolic process|stimulation of metabolic process GO:0044253 biological_process owl:Class GO:0030982 biolink:NamedThing adventurous gliding motility A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime. got7fsn_ti adventurous gliding movement biological_process owl:Class GO:0071976 biolink:NamedThing cell gliding Cell motility that results in the smooth movement of a cell along a solid surface. got7fsn_ti cell gliding motility mah 2010-10-21T02:33:24Z biological_process owl:Class GO:0052869 biolink:NamedThing arachidonic acid omega-hydroxylase activity Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid. got7fsn_ti arachidonic acid hydroxylase activity|arachidonic acid:oxygen 1-oxidoreductase activity ai 2012-01-30T03:05:27Z KEGG_REACTION:R07041|EC:1.14.15.3 molecular_function owl:Class GO:0002046 biolink:NamedThing opsin binding Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception. got7fsn_ti metarhodopsin binding GO:0016030 molecular_function owl:Class GO:0019139 biolink:NamedThing cytokinin dehydrogenase activity Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. got7fsn_ti N6-dimethylallyladenine:acceptor oxidoreductase activity|6-N-dimethylallyladenine:acceptor oxidoreductase activity|cytokinin oxidase activity|N6-dimethylallyladenine:(acceptor) oxidoreductase activity GO:0046420 EC:1.5.99.12|RHEA:13625|MetaCyc:PWY-2841|MetaCyc:1.5.99.12-RXN molecular_function owl:Class GO:0016645 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the CH-NH group of donors, other acceptors EC:1.5.-.- molecular_function owl:Class GO:0052076 biolink:NamedThing induction by symbiont of host ethylene-mediated defense response Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti up-regulation by symbiont of host ethylene-mediated defense response|positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction|stimulation by symbiont of host ethylene-mediated defense response|positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction|up regulation by symbiont of host ethylene-mediated defense response|positive regulation by symbiont of host ethylene-mediated defense response|activation by symbiont of host ethylene-mediated defense response|upregulation by symbiont of host ethylene-mediated defense response|positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway GO:0052269|GO:0052274|GO:0052071 biological_process owl:Class GO:0052028 biolink:NamedThing induction by symbiont of host signal transduction pathway Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti stimulation by symbiont of host signal transduction pathway|up regulation by symbiont of host signal transduction pathway|upregulation by symbiont of host signal transduction pathway|up-regulation by symbiont of host signal transduction pathway|activation by symbiont of host signal transduction pathway|positive regulation of signal transduction in other organism|positive regulation by organism of signal transduction in other organism involved in symbiotic interaction|positive regulation by symbiont of host signal transduction pathway GO:0052526|GO:0044502 biological_process owl:Class GO:0102941 biolink:NamedThing 3,5-dihydroxyanisole O-methyltransferase activity Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-9021 molecular_function owl:Class GO:0047043 biolink:NamedThing 3-alpha-hydroxycholanate dehydrogenase activity Catalysis of the reaction: lithocholate + NAD(+) = 3-oxo-5beta-cholanate + H(+) + NADH. got7fsn_ti alpha-hydroxy-cholanate dehydrogenase activity|3alpha-hydroxycholanate dehydrogenase activity|3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity MetaCyc:1.1.1.52-RXN|KEGG_REACTION:R04139|EC:1.1.1.52|RHEA:19585 molecular_function owl:Class GO:0021506 biolink:NamedThing anterior neuropore closure The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete. got7fsn_ti biological_process owl:Class GO:0016331 biolink:NamedThing morphogenesis of embryonic epithelium The process in which the anatomical structures of embryonic epithelia are generated and organized. got7fsn_ti biological_process owl:Class GO:0016926 biolink:NamedThing protein desumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. got7fsn_ti protein desumolation|desumoylation GO:0016928 biological_process owl:Class GO:0070646 biolink:NamedThing protein modification by small protein removal A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. got7fsn_ti mah 2009-05-11T01:58:15Z biological_process owl:Class GO:0036220 biolink:NamedThing ITP diphosphatase activity Catalysis of the reaction: ITP + H2O = IMP + diphosphate. got7fsn_ti inosine-5'-triphosphate pyrophosphohydrolase activity bf 2012-05-08T01:47:59Z KEGG_REACTION:R00720|Reactome:R-HSA-2509827|RHEA:29399|MetaCyc:RXN0-6382 molecular_function owl:Class GO:0047429 biolink:NamedThing nucleoside-triphosphate diphosphatase activity Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. got7fsn_ti nucleoside-triphosphate pyrophosphatase activity|nucleoside-triphosphate diphosphohydrolase activity EC:3.6.1.9|MetaCyc:3.6.1.19-RXN molecular_function owl:Class GO:0032176 biolink:NamedThing split septin rings A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well. got7fsn_ti cellular_component owl:Class GO:0032156 biolink:NamedThing septin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes. got7fsn_ti cellular_component owl:Class GO:0060777 biolink:NamedThing compound leaf morphogenesis The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development. got7fsn_ti dph 2009-07-25T07:12:30Z biological_process owl:Class GO:0009965 biolink:NamedThing leaf morphogenesis The process in which the anatomical structures of the leaf are generated and organized. got7fsn_ti biological_process owl:Class GO:0009231 biolink:NamedThing riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). got7fsn_ti vitamin G biosynthetic process|riboflavin formation|vitamin B2 biosynthesis|vitamin B2 biosynthetic process|riboflavin biosynthesis|riboflavin anabolism|vitamin G biosynthesis|riboflavin synthesis MetaCyc:RIBOSYN2-PWY|Wikipedia:Riboflavin biological_process owl:Class GO:0042364 biolink:NamedThing water-soluble vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water. got7fsn_ti water-soluble vitamin biosynthesis|water-soluble vitamin synthesis|water-soluble vitamin anabolism|water-soluble vitamin formation biological_process owl:Class GO:1990452 biolink:NamedThing Parkin-FBXW7-Cul1 ubiquitin ligase complex A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein. got7fsn_ti Parkin-HSel-10-Cullin-1 complex|PRKN-FBXW7-Cul1 complex|Parkin/Cul1/F-box protein complex|Parkin-FBXW7-Cul1 protein complex|Park2-FBXW7-Cul1 complex bf 2014-08-07T14:25:49Z cellular_component owl:Class GO:0000151 biolink:NamedThing ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. got7fsn_ti cellular_component owl:Class GO:0018397 biolink:NamedThing peptidyl-phenylalanine bromination to L-2'-bromophenylalanine The bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine. got7fsn_ti RESID:AA0174 biological_process owl:Class GO:0018075 biolink:NamedThing peptidyl-phenylalanine bromination The bromination of phenylalanine. got7fsn_ti RESID:AA0175|RESID:AA0174|RESID:AA0176 biological_process owl:Class GO:0003013 biolink:NamedThing circulatory system process A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. got7fsn_ti Wikipedia:Circulatory_system biological_process owl:Class GO:0007128 biolink:NamedThing meiotic prophase I The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class GO:0051324 biolink:NamedThing prophase The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Prophase biological_process owl:Class GO:0021527 biolink:NamedThing spinal cord association neuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti spinal cord dorsal interneuron differentiation biological_process owl:Class GO:0021515 biolink:NamedThing cell differentiation in spinal cord The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class GO:0120119 biolink:NamedThing flagellum attachment zone A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species. got7fsn_ti FAZ Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. krc 2017-12-11T22:46:43Z cellular_component owl:Class GO:0070161 biolink:NamedThing anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. got7fsn_ti anchoring cell junction cellular_component owl:Class GO:0000708 biolink:NamedThing meiotic strand invasion The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis. got7fsn_ti meiotic displacement loop formation|meiotic displacement loop biosynthesis|meiotic D-loop biosynthesis|meiotic D-loop formation biological_process owl:Class GO:0042148 biolink:NamedThing strand invasion The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. got7fsn_ti D-loop formation|displacement loop biosynthesis|Rad51-mediated strand invasion|D-loop biosynthesis|displacement loop formation biological_process owl:Class GO:0016598 biolink:NamedThing protein arginylation The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway. got7fsn_ti protein amino acid arginylation GO:0019130 biological_process owl:Class GO:0006464 biolink:NamedThing cellular protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). got7fsn_ti protein tagging activity|process resulting in protein modification|protein modification process biological_process owl:Class GO:0031571 biolink:NamedThing mitotic G1 DNA damage checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint. got7fsn_ti intracellular signal transduction pathway involved in G1 DNA damage checkpoint|intracellular signaling chain involved in G1/S DNA damage checkpoint|intracellular signal transduction involved in G1 DNA damage checkpoint|intracellular signaling pathway involved in G1 DNA damage checkpoint|signal transmission via intracellular cascade involved in G1 DNA damage checkpoint|intracellular signal transduction involved in G1/S DNA damage checkpoint|intracellular signaling pathway involved in G1/S DNA damage checkpoint|G1/S DNA damage checkpoint|intracellular signaling cascade involved in G1 DNA damage checkpoint|intracellular signaling chain involved in G1 DNA damage checkpoint|G1 DNA damage checkpoint|signal transduction via intracellular signaling cascade involved in G1/S DNA damage checkpoint|signal transduction involved in mitotic G1 DNA damage checkpoint|mitotic cell cycle G1/S transition DNA damage checkpoint|signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint|intracellular signal transduction pathway involved in G1/S DNA damage checkpoint|mitotic G1 DNA damage checkpoint|signal transduction via intracellular signaling cascade involved in G1 DNA damage checkpoint|intracellular signaling cascade involved in G1/S DNA damage checkpoint GO:0044783|GO:0072431|GO:1902400 biological_process owl:Class GO:0044819 biolink:NamedThing mitotic G1/S transition checkpoint signaling A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle. got7fsn_ti mitotic G1/S transition checkpoint https://github.com/geneontology/go-ontology/issues/20935 jl 2013-11-19T14:31:14Z biological_process owl:Class GO:0048518 biolink:NamedThing positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. got7fsn_ti activation of biological process|upregulation of biological process|positive regulation of physiological process|up regulation of biological process|up-regulation of biological process|stimulation of biological process GO:0043119 biological_process owl:Class GO:0005852 biolink:NamedThing eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. got7fsn_ti eIF-3|eIF3 cellular_component owl:Class GO:0018188 biolink:NamedThing peptidyl-proline di-hydroxylation The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline. got7fsn_ti RESID:AA0282 biological_process owl:Class GO:0019511 biolink:NamedThing peptidyl-proline hydroxylation The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. got7fsn_ti GO:0006472 biological_process owl:Class GO:0005385 biolink:NamedThing zinc ion transmembrane transporter activity Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. got7fsn_ti cobalt, zinc uptake permease activity|zinc, cadmium uptake permease activity|zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity|zinc, iron permease activity Reactome:R-HSA-442422|Reactome:R-HSA-437136|Reactome:R-HSA-437084|Reactome:R-HSA-435375|RHEA:29351|Reactome:R-HSA-442345|Reactome:R-HSA-435366|Reactome:R-HSA-437139|Reactome:R-HSA-442405|Reactome:R-HSA-437085|Reactome:R-HSA-442393|Reactome:R-HSA-437129|Reactome:R-HSA-442387|Reactome:R-HSA-5654125|Reactome:R-HSA-442317 molecular_function owl:Class GO:0022890 biolink:NamedThing inorganic cation transmembrane transporter activity Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. got7fsn_ti monovalent inorganic cation transmembrane transporter activity|trivalent inorganic cation transmembrane transporter activity|di-, tri-valent inorganic cation transmembrane transporter activity|divalent inorganic cation transmembrane transporter activity GO:0015082|GO:0015077|GO:0072509|GO:0072510 molecular_function owl:Class GO:0003046 biolink:NamedThing regulation of systemic arterial blood pressure by stress relaxation The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs. got7fsn_ti blood pressure regulation by stress relaxation biological_process owl:Class GO:0003085 biolink:NamedThing negative regulation of systemic arterial blood pressure The process that reduces the force with which blood travels through the systemic arterial circulatory system. got7fsn_ti biological_process owl:Class GO:0002468 biolink:NamedThing dendritic cell antigen processing and presentation The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti biological_process owl:Class GO:0044080 biolink:NamedThing modulation by symbiont of host cGMP-mediated signal transduction Any process in which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response. got7fsn_ti modulation by symbiont of host cGMP-mediated signaling|regulation by symbiont of host cGMP-mediated signal transduction|modulation of host cGMP-mediated signal transduction by symbiont|modulation by symbiont of host cGMP-mediated signalling|modulation by symbiont of host cGMP-mediated signal transduction pathway biological_process owl:Class GO:0010752 biolink:NamedThing regulation of cGMP-mediated signaling Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response. got7fsn_ti regulation of cGMP-mediated signalling biological_process owl:Class GO:0045605 biolink:NamedThing negative regulation of epidermal cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. got7fsn_ti down-regulation of epidermal cell differentiation|inhibition of epidermal cell differentiation|downregulation of epidermal cell differentiation|negative regulation of hypodermal cell differentiation|down regulation of epidermal cell differentiation biological_process owl:Class GO:0045683 biolink:NamedThing negative regulation of epidermis development Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. got7fsn_ti down regulation of epidermis development|negative regulation of epidermal development|negative regulation of hypodermis development|downregulation of epidermis development|down-regulation of epidermis development|inhibition of epidermis development biological_process owl:Class GO:0043330 biolink:NamedThing response to exogenous dsRNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. got7fsn_ti response to viral dsRNA|response to exogenous double-stranded RNA Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'. biological_process owl:Class GO:0043331 biolink:NamedThing response to dsRNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. got7fsn_ti response to double-stranded RNA biological_process owl:Class GO:0048446 biolink:NamedThing petal morphogenesis The process in which the anatomical structures of the petal are generated and organized. got7fsn_ti GO:0048418 biological_process owl:Class GO:0048444 biolink:NamedThing floral organ morphogenesis The process in which the anatomical structures of the floral organ are generated and organized. got7fsn_ti GO:0048434 biological_process owl:Class GO:0061648 biolink:NamedThing tooth replacement The process whose specific outcome is the replacement of an existing tooth with another tooth. got7fsn_ti dph 2014-10-02T15:26:53Z biological_process owl:Class GO:0042476 biolink:NamedThing odontogenesis The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. got7fsn_ti tooth development|odontogeny|tooth morphogenesis|odontogenesis of calcareous or chitinous tooth|odontosis GO:0042477 Wikipedia:Odontogenesis biological_process owl:Class GO:0043480 biolink:NamedThing pigment accumulation in tissues The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus. got7fsn_ti organismal pigment accumulation biological_process owl:Class GO:0052170 biolink:NamedThing suppression by symbiont of host innate immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation of host innate immune response|negative regulation by symbiont of host innate immunity|down regulation by symbiont of host innate immunity|inhibition by symbiont of host innate immunity|negative regulation by symbiont of host innate immune response|downregulation by symbiont of host innate immunity|down-regulation by symbiont of host innate immunity|negative regulation of innate immune response in other organism GO:0052309 biological_process owl:Class GO:0052562 biolink:NamedThing suppression by symbiont of host immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti down-regulation by symbiont of host immune response|inhibition by symbiont of host immune response|negative regulation by symbiont of host immune response|negative regulation by organism of immune response of other organism involved in symbiotic interaction|downregulation by symbiont of host immune response|down regulation by symbiont of host immune response GO:0052561 biological_process owl:Class GO:0036375 biolink:NamedThing Kibra-Ex-Mer complex An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2. got7fsn_ti Kbr, Ex and Mer complex|KEM complex bf 2013-05-07T10:05:15Z cellular_component owl:Class GO:0070357 biolink:NamedThing alphav-beta3 integrin-CD47 complex A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP). got7fsn_ti ITGB3-ITGAV-CD47 complex cellular_component owl:Class GO:1990065 biolink:NamedThing Dxr protein complex A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). got7fsn_ti 1-deoxy-D-xylulose 5-phosphate reductoisomerase complex bhm 2013-03-27T16:58:54Z cellular_component owl:Class GO:0036028 biolink:NamedThing protein C inhibitor-thrombin complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin. got7fsn_ti serpin A5-thrombin complex|plasma serine protease inhibitor-thrombin complex|PCI-thrombin complex|protein C inhibitor-coagulation factor II complex|protein C inhibitor-F2 complex|SERPINA5-thrombin complex bf 2011-10-19T01:40:18Z cellular_component owl:Class GO:0097180 biolink:NamedThing serine protease inhibitor complex A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity. got7fsn_ti serine-type endopeptidase inhibitor complex|serpin complex pr 2011-10-16T08:55:17Z cellular_component owl:Class GO:0036025 biolink:NamedThing protein C inhibitor-TMPRSS11E complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E. got7fsn_ti PCI-TMPRSS11E complex|SERPINA5-TMPRSS11E complex|plasma serine protease inhibitor-TMPRSS11E complex|serpin A5-TMPRSS11E complex|protein C inhibitor-transmembrane protease serine 11E complex bf 2011-10-19T01:29:08Z cellular_component owl:Class GO:0002205 biolink:NamedThing somatic hypermutation of immunoglobulin genes involved in immune response Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response. got7fsn_ti somatic hypermutation of immunoglobulin genes during immune response|somatic hypermutation of antibody genes during immune response biological_process owl:Class GO:0016446 biolink:NamedThing somatic hypermutation of immunoglobulin genes Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. got7fsn_ti somatic hypermutation of antibody genes biological_process owl:Class GO:0030649 biolink:NamedThing aminoglycoside antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. got7fsn_ti aminoglycoside antibiotic degradation|aminoglycoside antibiotic breakdown|aminoglycoside antibiotic catabolism biological_process owl:Class GO:0017001 biolink:NamedThing antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. got7fsn_ti antibiotic catabolism|antibiotic degradation|antibiotic breakdown biological_process owl:Class GO:0035132 biolink:NamedThing post-embryonic medial fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. got7fsn_ti post-embryonic unpaired fin morphogenesis biological_process owl:Class GO:0035120 biolink:NamedThing post-embryonic appendage morphogenesis The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. got7fsn_ti biological_process owl:Class GO:0035622 biolink:NamedThing intrahepatic bile duct development The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). got7fsn_ti IHBD development|intrahepatic biliary duct development bf 2010-12-08T04:10:50Z biological_process owl:Class GO:0061827 biolink:NamedThing sperm head The part of the late spermatid or spermatozoon that contains the nucleus and acrosome. got7fsn_ti dph 2017-01-15T10:39:00Z cellular_component owl:Class GO:0098518 biolink:NamedThing polynucleotide phosphatase activity Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate. got7fsn_ti dos 2013-09-26T11:02:35Z molecular_function owl:Class GO:0010374 biolink:NamedThing stomatal complex development The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells. got7fsn_ti biological_process owl:Class GO:0032200 biolink:NamedThing telomere organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. got7fsn_ti organization of chromosome, telomeric region|telomere organization and biogenesis|telomere organisation|chromosome organization, telomeric biological_process owl:Class GO:0051276 biolink:NamedThing chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. got7fsn_ti maintenance of genome integrity|chromosome organization and biogenesis|nuclear genome maintenance|chromosome organisation GO:0051277|GO:0007001 biological_process owl:Class GO:0033103 biolink:NamedThing protein secretion by the type VI secretion system The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence. got7fsn_ti protein secretion by the T6SS|type VI protein secretion system|protein secretion by the type VI protein secretion system Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'. biological_process owl:Class GO:0047961 biolink:NamedThing glycine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. got7fsn_ti acyl-CoA:glycine N-acyltransferase activity|glycine acyltransferase activity|glycine-N-acylase activity MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN|RHEA:19869|EC:2.3.1.13|Reactome:R-HSA-2534040 molecular_function owl:Class GO:0030175 biolink:NamedThing filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. got7fsn_ti A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473. GO:0030028 NIF_Subcellular:sao1046371754|Wikipedia:Filopodia cellular_component owl:Class GO:0098858 biolink:NamedThing actin-based cell projection A cell projection supported by an assembly of actin filaments, and which lacks microtubules. got7fsn_ti cellular_component owl:Class GO:0032341 biolink:NamedThing aldosterone metabolic process The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. got7fsn_ti aldosterone metabolism biological_process owl:Class GO:0008207 biolink:NamedThing C21-steroid hormone metabolic process The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. got7fsn_ti C21-steroid hormone metabolism biological_process owl:Class GO:0035993 biolink:NamedThing deltoid tuberosity development The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase. got7fsn_ti bf 2011-08-30T01:46:53Z biological_process owl:Class GO:0018725 biolink:NamedThing trans-3,4-dihydrodiolphenanthrene sulfotransferase activity Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate. got7fsn_ti trans-3,4-dihydrodiolphenanthrene sulphotransferase activity UM-BBD_reactionID:r0558 molecular_function owl:Class GO:0071261 biolink:NamedThing Ssh1 translocon complex A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences. got7fsn_ti Ssh1p-Sss1p-Sbh2p complex mah 2009-12-08T02:22:55Z cellular_component owl:Class GO:0071256 biolink:NamedThing translocon complex A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins. got7fsn_ti Sec complex-associated translocon complex mah 2009-12-08T02:08:03Z GO:0031206 cellular_component owl:Class GO:0040019 biolink:NamedThing positive regulation of embryonic development Any process that activates or increases the frequency, rate or extent of embryonic development. got7fsn_ti up-regulation of embryonic development|stimulation of embryonic development|upregulation of embryonic development|up regulation of embryonic development|activation of embryonic development biological_process owl:Class GO:0051094 biolink:NamedThing positive regulation of developmental process Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). got7fsn_ti activation of developmental process|stimulation of developmental process|up-regulation of developmental process|upregulation of developmental process|up regulation of developmental process biological_process owl:Class GO:0048098 biolink:NamedThing antennal joint development The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments. got7fsn_ti biological_process owl:Class GO:0042128 biolink:NamedThing nitrate assimilation The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances. got7fsn_ti assimilatory nitrate reduction MetaCyc:PWY-381 biological_process owl:Class GO:0071941 biolink:NamedThing nitrogen cycle metabolic process A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. got7fsn_ti mah 2010-09-30T05:21:03Z Wikipedia:Nitrogen_cycle biological_process owl:Class GO:0050639 biolink:NamedThing 10-hydroxytaxane O-acetyltransferase activity Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C. got7fsn_ti acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity|acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity|acetyl-CoA:taxan-10beta-ol O-acetyltransferase EC:2.3.1.163|MetaCyc:2.3.1.163-RXN|RHEA:18837|KEGG_REACTION:R07252 molecular_function owl:Class GO:1902105 biolink:NamedThing regulation of leukocyte differentiation Any process that modulates the frequency, rate or extent of leukocyte differentiation. got7fsn_ti regulation of immune cell differentiation|regulation of leucocyte differentiation pr 2013-05-02T17:32:42Z biological_process owl:Class GO:0045595 biolink:NamedThing regulation of cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. got7fsn_ti biological_process owl:Class GO:0004956 biolink:NamedThing prostaglandin D receptor activity Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity. got7fsn_ti PGD receptor activity|PGD(2) receptor activity molecular_function owl:Class GO:0004955 biolink:NamedThing prostaglandin receptor activity Combining with a prostaglandin (PG) to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class GO:0016217 biolink:NamedThing N-ethylammeline chlorohydrolase activity Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+. got7fsn_ti MetaCyc:R465-RXN molecular_function owl:Class GO:0019120 biolink:NamedThing hydrolase activity, acting on acid halide bonds, in C-halide compounds Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage. got7fsn_ti Reactome:R-HSA-9011595|EC:3.8.1.- molecular_function owl:Class GO:0070065 biolink:NamedThing cellubrevin-VAMP4-syntaxin-16 complex A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof). got7fsn_ti Vamp3-Vamp4-Stx16 complex|SNARE complex (Vamp3, Vamp4, Stx16) cellular_component owl:Class GO:0031201 biolink:NamedThing SNARE complex A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. got7fsn_ti cellular_component owl:Class GO:0090565 biolink:NamedThing protein-phosphocysteine-mannitol phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti tb 2014-04-08T15:03:08Z molecular_function owl:Class GO:0090563 biolink:NamedThing protein-phosphocysteine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti tb 2014-04-08T14:58:00Z molecular_function owl:Class GO:0099610 biolink:NamedThing action potential initiation The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate. got7fsn_ti action potential firing|action potential triggering biological_process owl:Class GO:0001508 biolink:NamedThing action potential A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. got7fsn_ti Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. biological_process owl:Class GO:0030629 biolink:NamedThing U6 snRNA 3'-end binding Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end. got7fsn_ti U6 snRNA 3' end binding Note that this term may be useful for annotating small nuclear RNAs (snRNAs). molecular_function owl:Class GO:0017070 biolink:NamedThing U6 snRNA binding Binding to a U6 small nuclear RNA (U6 snRNA). got7fsn_ti molecular_function owl:Class GO:1990428 biolink:NamedThing miRNA transport The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. got7fsn_ti microRNA transport jl 2014-07-29T14:03:46Z biological_process owl:Class GO:0050658 biolink:NamedThing RNA transport The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class GO:0051468 biolink:NamedThing detection of glucocorticoid hormone stimulus The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. got7fsn_ti biological_process owl:Class GO:0051384 biolink:NamedThing response to glucocorticoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. got7fsn_ti response to glucocorticoid stimulus biological_process owl:Class GO:0099015 biolink:NamedThing degradation of host chromosome by virus The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis. got7fsn_ti VZ:3947 biological_process owl:Class GO:0039637 biolink:NamedThing catabolism by virus of host DNA The breakdown of host DNA, deoxyribonucleic acid, by a virus. got7fsn_ti bf 2012-08-10T15:59:22Z biological_process owl:Class GO:0061681 biolink:NamedThing Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate. got7fsn_ti dph 2015-01-22T08:55:22Z MetaCyc:ENTNER-DOUDOROFF-PWY-III biological_process owl:Class GO:0061679 biolink:NamedThing Entner-Doudoroff pathway through gluconate The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate. got7fsn_ti gluconate pathway dph 2015-01-16T15:41:22Z biological_process owl:Class GO:0044525 biolink:NamedThing peptidyl-cystine sulfhydration The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide. got7fsn_ti jl 2012-03-15T09:44:07Z biological_process owl:Class GO:0044524 biolink:NamedThing protein sulfhydration The modification of a protein amino acid by the addition of sulfur. got7fsn_ti jl 2012-03-15T09:39:33Z biological_process owl:Class GO:0086073 biolink:NamedThing bundle of His cell-Purkinje myocyte adhesion involved in cell communication The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate. got7fsn_ti dph 2011-11-22T10:00:30Z biological_process owl:Class GO:0034113 biolink:NamedThing heterotypic cell-cell adhesion The attachment of a cell to a cell of a different type via adhesion molecules. got7fsn_ti Note that this term is not synonymous with 'heterophilic cell adhesion ; GO:0007157'; the process may occur by homophilic or heterophilic mechanisms. biological_process owl:Class GO:0007339 biolink:NamedThing binding of sperm to zona pellucida The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. got7fsn_ti ZPG binding biological_process owl:Class GO:0035036 biolink:NamedThing sperm-egg recognition The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. got7fsn_ti biological_process owl:Class GO:1903042 biolink:NamedThing negative regulation of chondrocyte hypertrophy Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy. got7fsn_ti down regulation of chondrocyte hypertrophy|inhibition of chondrocyte hypertrophy|down-regulation of chondrocyte hypertrophy|downregulation of chondrocyte hypertrophy mr 2014-05-20T21:23:19Z biological_process owl:Class GO:0042861 biolink:NamedThing achromobactin biosynthetic process The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore. got7fsn_ti achromobactin anabolism|achromobactin formation|achromobactin synthesis|achromobactin biosynthesis GO:0031182|GO:0031181 biological_process owl:Class GO:0019290 biolink:NamedThing siderophore biosynthetic process The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. got7fsn_ti siderophore biosynthetic process, peptide formation|siderophore biosynthesis|siderochrome biosynthetic process|siderophore anabolism|siderophore formation|siderochrome biosynthesis|siderophore synthesis|siderophore biosynthetic process, peptide modification GO:0031180|GO:0031178 biological_process owl:Class GO:0032076 biolink:NamedThing negative regulation of deoxyribonuclease activity Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. got7fsn_ti downregulation of deoxyribonuclease activity|deoxyribonuclease inhibitor|down regulation of deoxyribonuclease activity|inhibition of deoxyribonuclease activity|DNase inhibitor|down-regulation of deoxyribonuclease activity biological_process owl:Class GO:0051053 biolink:NamedThing negative regulation of DNA metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. got7fsn_ti inhibition of DNA metabolic process|down-regulation of DNA metabolic process|negative regulation of DNA metabolism|down regulation of DNA metabolic process|downregulation of DNA metabolic process biological_process owl:Class GO:0102144 biolink:NamedThing carboxyspermidine dehydrogenase II activity Catalysis of the reaction: carboxyspermidine + H2O + NADP <=> L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+. got7fsn_ti MetaCyc:RXN-11566|RHEA:34111 molecular_function owl:Class GO:0044839 biolink:NamedThing cell cycle G2/M phase transition The cell cycle process by which a cell in G2 phase commits to M phase. got7fsn_ti jl 2014-03-05T14:56:45Z biological_process owl:Class GO:0044770 biolink:NamedThing cell cycle phase transition The cell cycle process by which a cell commits to entering the next cell cycle phase. got7fsn_ti cell cycle transition jl 2013-02-28T12:54:59Z biological_process owl:Class GO:0050845 biolink:NamedThing teichuronic acid biosynthetic process The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria. got7fsn_ti teichuronic acid anabolism|teichuronic acid biosynthesis|teichuronic acid formation|teichuronic acid synthesis biological_process owl:Class GO:0016053 biolink:NamedThing organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. got7fsn_ti organic acid biosynthesis|organic acid formation|organic acid synthesis|organic acid anabolism biological_process owl:Class GO:0002240 biolink:NamedThing response to molecule of oomycetes origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin. got7fsn_ti response to oomycetes associated molecule biological_process owl:Class GO:0010033 biolink:NamedThing response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. got7fsn_ti process resulting in tolerance to organic substance GO:1990367 biological_process owl:Class GO:0016775 biolink:NamedThing phosphotransferase activity, nitrogenous group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). got7fsn_ti EC:2.7.3.- molecular_function owl:Class GO:0016772 biolink:NamedThing transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). got7fsn_ti Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. EC:2.7.-.- molecular_function owl:Class GO:0033142 biolink:NamedThing progesterone receptor binding Binding to a progesterone receptor. got7fsn_ti molecular_function owl:Class GO:0016922 biolink:NamedThing nuclear receptor binding Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. got7fsn_ti steroid hormone receptor binding|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|ligand-dependent nuclear receptor interactor activity GO:0035257|GO:0035258 molecular_function owl:Class GO:0120223 biolink:NamedThing larynx morphogenesis The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration. got7fsn_ti laryngeal morphogenesis krc 2020-02-22T01:42:04Z biological_process owl:Class GO:0009887 biolink:NamedThing animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti histogenesis and organogenesis biological_process owl:Class GO:0036284 biolink:NamedThing tubulobulbar complex Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes. got7fsn_ti TBC bf 2012-07-16T10:26:35Z cellular_component owl:Class GO:0032541 biolink:NamedThing cortical endoplasmic reticulum A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. got7fsn_ti ER-PM peripheral junction|peripheral ER|peripheral endoplasmic reticulum|cortical ER The dynamic nature of the cortical ER and the movements it undergoes (branching and ring closure) has been shown in both yeast and mammalian cells, so appears highly conserved. (PMID:10931860) cellular_component owl:Class GO:0071782 biolink:NamedThing endoplasmic reticulum tubular network A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. got7fsn_ti ER tubular network mah 2010-09-01T01:32:55Z cellular_component owl:Class GO:0036018 biolink:NamedThing cellular response to erythropoietin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. got7fsn_ti bf 2011-10-12T10:12:18Z biological_process owl:Class GO:0071345 biolink:NamedThing cellular response to cytokine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. got7fsn_ti mah 2009-12-11T02:41:12Z biological_process owl:Class GO:0060172 biolink:NamedThing astral microtubule depolymerization The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. got7fsn_ti biological_process owl:Class GO:0001982 biolink:NamedThing baroreceptor response to decreased systemic arterial blood pressure The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels. got7fsn_ti biological_process owl:Class GO:0003084 biolink:NamedThing positive regulation of systemic arterial blood pressure The process that increases the force with which blood travels through the systemic arterial circulatory system. got7fsn_ti biological_process owl:Class GO:0071603 biolink:NamedThing endothelial cell-cell adhesion The attachment of an endothelial cell to another endothelial cell via adhesion molecules. got7fsn_ti mah 2010-02-04T05:21:30Z biological_process owl:Class GO:0090136 biolink:NamedThing epithelial cell-cell adhesion The attachment of an epithelial cell to another epithelial cell via adhesion molecules. got7fsn_ti tb 2009-12-08T01:56:53Z biological_process owl:Class GO:0007523 biolink:NamedThing larval visceral muscle development The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class GO:0007522 biolink:NamedThing visceral muscle development The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class GO:0071755 biolink:NamedThing IgM B cell receptor complex An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti surface IgM|membrane-bound IgM Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class GO:0071753 biolink:NamedThing IgM immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class GO:0008170 biolink:NamedThing N-methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. got7fsn_ti EC:2.1.1.- molecular_function owl:Class GO:0099558 biolink:NamedThing maintenance of synapse structure A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. got7fsn_ti synaptic maintenance biological_process owl:Class GO:0050808 biolink:NamedThing synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). got7fsn_ti synapse organisation|synapse development|synapse organization and biogenesis|synapse morphogenesis biological_process owl:Class GO:0051363 biolink:NamedThing peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan. got7fsn_ti Note that this modification may be unique to the species Finegoldia (Peptostreptococcus) magnus. RESID:AA0383 biological_process owl:Class GO:0018194 biolink:NamedThing peptidyl-alanine modification The modification of peptidyl-alanine. got7fsn_ti biological_process owl:Class GO:0035649 biolink:NamedThing Nrd1 complex A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p. got7fsn_ti bf 2011-01-25T10:23:25Z cellular_component owl:Class GO:0047878 biolink:NamedThing erythritol kinase activity Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H(+). got7fsn_ti ATP:erythritol 4-phosphotransferase activity|erythritol kinase (phosphorylating) MetaCyc:ERYTHRITOL-KINASE-RXN|EC:2.7.1.27|KEGG_REACTION:R02430|RHEA:20708 molecular_function owl:Class GO:0010244 biolink:NamedThing response to low fluence blue light stimulus by blue low-fluence system Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes. got7fsn_ti response to low fluence blue light|response to low fluence blue light by blf system biological_process owl:Class GO:0021637 biolink:NamedThing trigeminal nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. got7fsn_ti CN V structural organization|trigeminal nerve structural organisation biological_process owl:Class GO:0021604 biolink:NamedThing cranial nerve structural organization The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. got7fsn_ti cranial nerve structural organisation biological_process owl:Class GO:0035851 biolink:NamedThing Krueppel-associated box domain binding Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors. got7fsn_ti KRAB domain binding|Krueppel-associated box binding bf 2011-05-11T11:41:16Z molecular_function owl:Class GO:0055013 biolink:NamedThing cardiac muscle cell development The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. got7fsn_ti cardiomyocyte cell development|heart muscle cell development|heart muscle fiber development|cardiac muscle fiber development|cardiac muscle fibre development GO:0048739 biological_process owl:Class GO:0055006 biolink:NamedThing cardiac cell development The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. got7fsn_ti heart cell development|cardiocyte development biological_process owl:Class GO:0090598 biolink:NamedThing male anatomical structure morphogenesis The processes by which anatomical structures that are only present in the male organism are generated and organized. got7fsn_ti tb 2014-08-22T13:29:45Z biological_process owl:Class GO:0009653 biolink:NamedThing anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. got7fsn_ti anatomical structure organization|morphogenesis|embryogenesis and morphogenesis Wikipedia:Morphogenesis biological_process owl:Class GO:0072558 biolink:NamedThing NLRP1 inflammasome complex An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential. got7fsn_ti NALP1 inflammasome complex mah 2011-01-27T12:03:50Z cellular_component owl:Class GO:0036460 biolink:NamedThing cellular response to cell envelope stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope. got7fsn_ti envelope stress response bf 2014-01-08T15:15:50Z biological_process owl:Class GO:0009528 biolink:NamedThing plastid inner membrane The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma. got7fsn_ti cellular_component owl:Class GO:0042170 biolink:NamedThing plastid membrane Either of the lipid bilayers that surround a plastid and form the plastid envelope. got7fsn_ti cellular_component owl:Class GO:0048257 biolink:NamedThing 3'-flap endonuclease activity Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis. got7fsn_ti 3' flap endonuclease activity molecular_function owl:Class GO:0098735 biolink:NamedThing positive regulation of the force of heart contraction Any process that increases the force of heart muscle contraction. got7fsn_ti biological_process owl:Class GO:0002026 biolink:NamedThing regulation of the force of heart contraction Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. got7fsn_ti heart inotropy|cardiac inotropy biological_process owl:Class GO:0006315 biolink:NamedThing homing of group II introns Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure. got7fsn_ti biological_process owl:Class GO:0018666 biolink:NamedThing 2,4-dichlorophenol 6-monooxygenase activity Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O. got7fsn_ti 2,4-dichlorophenol hydroxylase activity|2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)|2,4-dichlorophenol monooxygenase activity EC:1.14.13.20|MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN|RHEA:20920|UM-BBD_enzymeID:e0152 molecular_function owl:Class GO:0098736 biolink:NamedThing negative regulation of the force of heart contraction Any process that decreases the force of heart muscle contraction. got7fsn_ti biological_process owl:Class GO:0075130 biolink:NamedThing modulation by symbiont of host protein kinase-mediated signal transduction Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075099". biological_process owl:Class GO:0052027 biolink:NamedThing modulation by symbiont of host signal transduction pathway Any process in which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host signal transduction|modulation of host signal transduction by symbiont|modulation of signal transduction in other organism involved in symbiotic interaction|regulation by symbiont of host signal transduction pathway GO:0052250 biological_process owl:Class GO:0046565 biolink:NamedThing 3-dehydroshikimate dehydratase activity Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. got7fsn_ti EC:4.2.1.118|MetaCyc:DHSHIKIMATE-DEHYDRO-RXN|RHEA:24848 molecular_function owl:Class GO:0062095 biolink:NamedThing endoplasmic reticulum-peroxisome tethering The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other. got7fsn_ti dph 2018-11-21T13:28:50Z biological_process owl:Class GO:0060151 biolink:NamedThing peroxisome localization Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. got7fsn_ti peroxisome localisation biological_process owl:Class GO:0009083 biolink:NamedThing branched-chain amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. got7fsn_ti branched chain family amino acid degradation|branched chain family amino acid breakdown|branched chain family amino acid catabolic process|branched chain family amino acid catabolism biological_process owl:Class GO:0009063 biolink:NamedThing cellular amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. got7fsn_ti cellular amino acid breakdown|amino acid catabolic process|cellular amino acid degradation|cellular amino acid catabolism biological_process owl:Class GO:0005703 biolink:NamedThing polytene chromosome puff A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription. got7fsn_ti cellular_component owl:Class GO:0098687 biolink:NamedThing chromosomal region Any subdivision of a chromosome along its length. got7fsn_ti chromosome region Chromosomal regions include parts that are not part of the chromatin. Examples include the kinetochore. cellular_component owl:Class GO:0034317 biolink:NamedThing nicotinic acid riboside kinase activity Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide. got7fsn_ti MetaCyc:RXN-8443 molecular_function owl:Class GO:0019206 biolink:NamedThing nucleoside kinase activity Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. got7fsn_ti Reactome:R-HSA-109903|Reactome:R-HSA-73598|Reactome:R-HSA-110137|Reactome:R-HSA-109671|Reactome:R-HSA-73632|Reactome:R-HSA-74207|Reactome:R-HSA-73599|Reactome:R-HSA-109759|Reactome:R-HSA-110138 molecular_function owl:Class GO:0043050 biolink:NamedThing pharyngeal pumping The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes. got7fsn_ti pumping behavior biological_process owl:Class GO:0042755 biolink:NamedThing eating behavior The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. got7fsn_ti eating behaviour biological_process owl:Class GO:0050240 biolink:NamedThing pyrogallol 1,2-oxygenase activity Catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+). got7fsn_ti pyrogallol 1,2-dioxygenase activity|1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing) MetaCyc:PYROGALLOL-12-OXYGENASE-RXN|KEGG_REACTION:R03246|RHEA:19673|EC:1.13.11.35 molecular_function owl:Class GO:0047212 biolink:NamedThing 2-coumarate O-beta-glucosyltransferase activity Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H(+) + UDP. got7fsn_ti UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity|UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity|UDPG:o-coumaric acid O-glucosyltransferase activity|uridine diphosphoglucose-o-coumarate glucosyltransferase activity MetaCyc:2.4.1.114-RXN|KEGG_REACTION:R03710|EC:2.4.1.114|RHEA:10236 molecular_function owl:Class GO:0035251 biolink:NamedThing UDP-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. got7fsn_ti Reactome:R-HSA-1912353|MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN molecular_function owl:Class GO:0035747 biolink:NamedThing natural killer cell chemotaxis The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti bf 2011-03-17T02:40:10Z biological_process owl:Class GO:0048247 biolink:NamedThing lymphocyte chemotaxis The directed movement of a lymphocyte in response to an external stimulus. got7fsn_ti biological_process owl:Class GO:0061860 biolink:NamedThing DNA clamp unloader activity Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis. got7fsn_ti dph 2017-04-03T11:49:46Z molecular_function owl:Class GO:0008094 biolink:NamedThing ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. got7fsn_ti ATPase, acting on DNA|ATPase activity, acting on DNA|DNA-dependent adenosinetriphosphatase activity|adenosinetriphosphatase (DNA-dependent)|DNA dependent ATPase activity|DNA-dependent ATPase activity https://github.com/geneontology/go-ontology/issues/20876|https://github.com/geneontology/go-ontology/issues/21612|https://github.com/geneontology/go-ontology/issues/21775 GO:0004011 molecular_function owl:Class GO:0018682 biolink:NamedThing atrazine N-dealkylase activity Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O. got7fsn_ti atrazine monooxygenase activity MetaCyc:R461-RXN|UM-BBD_reactionID:r0127|EC:1.14.15.- molecular_function owl:Class GO:0140313 biolink:NamedThing molecular sequestering activity The selective interaction of a protein with a specific molecule to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell. got7fsn_ti pg 2019-03-28T10:00:25Z molecular_function owl:Class GO:0097068 biolink:NamedThing response to thyroxine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. got7fsn_ti response to thyroxine stimulus|response to T4 stimulus|response to T4 pr 2011-06-14T05:05:07Z biological_process owl:Class GO:0097066 biolink:NamedThing response to thyroid hormone A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. got7fsn_ti response to thyroid hormone stimulus pr 2011-06-14T05:01:18Z biological_process owl:Class GO:0021895 biolink:NamedThing cerebral cortex neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. got7fsn_ti biological_process owl:Class GO:0021953 biolink:NamedThing central nervous system neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. got7fsn_ti biological_process owl:Class GO:0003241 biolink:NamedThing growth involved in heart morphogenesis Developmental growth that contributes to the shaping of the heart. got7fsn_ti dph 2009-10-13T11:28:46Z biological_process owl:Class GO:0016402 biolink:NamedThing pristanoyl-CoA oxidase activity Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide. got7fsn_ti RHEA:40459|Reactome:R-HSA-389889|Reactome:R-HSA-389891 molecular_function owl:Class GO:0003997 biolink:NamedThing acyl-CoA oxidase activity Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. got7fsn_ti fatty acyl-CoA oxidase activity|acyl-CoA:oxygen 2-oxidoreductase activity|fatty acyl-coenzyme A oxidase activity|acyl coenzyme A oxidase activity RHEA:38959|EC:1.3.3.6|Reactome:R-HSA-193369|Reactome:R-HSA-390256|Reactome:R-HSA-2066787|Reactome:R-HSA-192335|MetaCyc:ACYL-COA-OXIDASE-RXN molecular_function owl:Class GO:0050988 biolink:NamedThing N-terminal peptidyl-methionine carboxylation The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine. got7fsn_ti RESID:AA0363 biological_process owl:Class GO:0050989 biolink:NamedThing N-terminal protein amino acid carboxylation The carboxylation of the N-terminal amino acid of proteins. got7fsn_ti biological_process owl:Class GO:0051403 biolink:NamedThing stress-activated MAPK cascade A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. got7fsn_ti MAPK14 cascade|MAPK12 cascade|stress-activated MAPKKK signalling pathway|p38 MAPK signaling|stress-activated MAPK signaling pathway|p38 cascade|p38 MAPK signalling|MAPK11 cascade|stress-activated MAPK signalling pathway|MAPK13 cascade|stress-activated MAPKKK signaling pathway|SAPK cascade|stress-activated MAPKKK cascade biological_process owl:Class GO:0031098 biolink:NamedThing stress-activated protein kinase signaling cascade A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. got7fsn_ti JNK signalling pathway|stress-activated protein kinase signaling pathway|stress-activated protein kinase signalling pathway|JNK signaling pathway|SAPK signalling pathway|SAPK signaling pathway biological_process owl:Class GO:0038086 biolink:NamedThing VEGF-activated platelet-derived growth factor receptor signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGF-activated platelet-derived growth factor receptor signalling pathway|vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway|VEGF-activated PDGFR signalling pathway|VEGF/PDGFR signaling pathway|VEGF-A/PDGFR signaling bf 2012-02-01T03:05:43Z biological_process owl:Class GO:0048008 biolink:NamedThing platelet-derived growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. got7fsn_ti PDGFR signaling pathway|PDGF receptor signalling pathway|PDGF receptor signaling pathway biological_process owl:Class GO:0097226 biolink:NamedThing sperm mitochondrial sheath The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. got7fsn_ti pr 2012-01-25T01:25:08Z cellular_component owl:Class GO:0060735 biolink:NamedThing regulation of eIF2 alpha phosphorylation by dsRNA Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA. got7fsn_ti regulation of eIF2 alpha phosphorylation by double-stranded RNA|regulation of eIF2 alpha phosphorylation by PKR dph 2009-06-12T02:27:14Z biological_process owl:Class GO:0001932 biolink:NamedThing regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. got7fsn_ti regulation of protein amino acid phosphorylation biological_process owl:Class GO:0050079 biolink:NamedThing acetylenecarboxylate hydratase activity, producing 3-oxopropanoate Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O. got7fsn_ti 3-oxopropanoate hydro-lyase activity|acetylmonocarboxylic acid hydrase activity|acetylenecarboxylate hydratase activity|acetylenemonocarboxylate hydrase activity|acetylenemonocarboxylate hydratase activity|malonate-semialdehyde dehydratase activity|acetylenecarboxylate hydratase activity, producing malonate-semialdehyde|alkynoate hydratase activity|3-oxopropanoate hydro-lyase (propynoate-forming) Note that this function was formerly EC:4.2.1.71. GO:0047607 EC:4.2.1.27|MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN|RHEA:17957 molecular_function owl:Class GO:0021601 biolink:NamedThing abducens nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. got7fsn_ti CN VI maturation biological_process owl:Class GO:0021605 biolink:NamedThing cranial nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. got7fsn_ti biological_process owl:Class GO:0072683 biolink:NamedThing T cell extravasation The migration of a T cell from the blood vessels into the surrounding tissue. got7fsn_ti T lymphocyte extravasation|T-lymphocyte extravasation|T-cell extravasation mah 2011-02-22T04:05:45Z biological_process owl:Class GO:0045123 biolink:NamedThing cellular extravasation The migration of a leukocyte from the blood vessels into the surrounding tissue. got7fsn_ti immune cell cellular extravasation|leucocyte cellular extravasation|transendothelial leukocyte migration|leukocyte cellular extravasation Wikipedia:Leukocyte_extravasation biological_process owl:Class GO:0021700 biolink:NamedThing developmental maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. got7fsn_ti biological_process owl:Class GO:0048932 biolink:NamedThing myelination of posterior lateral line nerve axons The formation of compact myelin sheaths around the axons of the posterior lateral line nerve. got7fsn_ti biological_process owl:Class GO:0048897 biolink:NamedThing myelination of lateral line nerve axons The formation of compact myelin sheaths around the axons of a lateral line nerve. got7fsn_ti biological_process owl:Class GO:0061202 biolink:NamedThing clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle. got7fsn_ti clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted GABA transport vesicle membrane dph 2010-07-29T10:54:33Z cellular_component owl:Class GO:0030665 biolink:NamedThing clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle. got7fsn_ti clathrin coated vesicle membrane cellular_component owl:Class GO:0009718 biolink:NamedThing anthocyanin-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. got7fsn_ti anthocyanin biosynthesis|anthocyanin biosynthetic process|anthocyanin synthesis|anthocyanin anabolism|anthocyanin formation biological_process owl:Class GO:0046148 biolink:NamedThing pigment biosynthetic process The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. got7fsn_ti pigment synthesis|pigment formation|pigment biosynthesis|pigment anabolism biological_process owl:Class GO:0007295 biolink:NamedThing growth of a germarium-derived egg chamber Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster. got7fsn_ti egg chamber growth biological_process owl:Class GO:0048589 biolink:NamedThing developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. got7fsn_ti biological_process owl:Class GO:0072205 biolink:NamedThing metanephric collecting duct development The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder. got7fsn_ti mah 2010-03-18T11:15:37Z biological_process owl:Class GO:0072044 biolink:NamedThing collecting duct development The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. got7fsn_ti mah 2010-01-25T03:18:06Z biological_process owl:Class GO:0001700 biolink:NamedThing embryonic development via the syncytial blastoderm The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class GO:0009792 biolink:NamedThing embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. got7fsn_ti embryogenesis biological_process owl:Class GO:0009267 biolink:NamedThing cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. got7fsn_ti biological_process owl:Class GO:0042594 biolink:NamedThing response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. got7fsn_ti biological_process owl:Class GO:0014745 biolink:NamedThing negative regulation of muscle adaptation Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. got7fsn_ti negative regulation of muscle plasticity biological_process owl:Class GO:0048585 biolink:NamedThing negative regulation of response to stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. got7fsn_ti down-regulation of response to stimulus|inhibition of response to stimulus|downregulation of response to stimulus|down regulation of response to stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0047363 biolink:NamedThing triglucosylalkylacylglycerol sulfotransferase activity Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate. got7fsn_ti triglucosylalkylacylglycerol sulphotransferase activity|3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity|triglucosylmonoalkylmonoacyl sulfotransferase activity RHEA:13273|EC:2.8.2.19|MetaCyc:2.8.2.19-RXN molecular_function owl:Class GO:0042771 biolink:NamedThing intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. got7fsn_ti DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis biological_process owl:Class GO:0072332 biolink:NamedThing intrinsic apoptotic signaling pathway by p53 class mediator A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. got7fsn_ti intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|signal transduction by p53 class mediator resulting in induction of apoptosis mah 2010-11-03T01:47:56Z biological_process owl:Class GO:0140338 biolink:NamedThing sphingomyelin transfer activity Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. got7fsn_ti sphingosine transmembrane transporter activity|sphingomyelin carrier activity pg 2019-05-16T11:31:58Z GO:0010175 molecular_function owl:Class GO:0120013 biolink:NamedThing lipid transfer activity Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids. got7fsn_ti lipid carrier activity|intermembrane lipid transfer activity https://github.com/geneontology/go-ontology/issues/12329|https://github.com/geneontology/go-ontology/issues/17648 krc 2017-03-17T03:17:29Z molecular_function owl:Class GO:0004134 biolink:NamedThing 4-alpha-glucanotransferase activity Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. got7fsn_ti D-enzyme activity|amylomaltase activity|oligo-1,4-1,4-glucantransferase activity|debranching enzyme maltodextrin glycosyltransferase activity|1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity|dextrin glycosyltransferase activity|disproportionating enzyme activity|dextrin transglycosylase activity Reactome:R-HSA-71552|MetaCyc:RXN-1828|MetaCyc:RXN-9023|EC:2.4.1.25|MetaCyc:AMYLOMALT-RXN molecular_function owl:Class GO:0004133 biolink:NamedThing glycogen debranching enzyme activity Catalysis of the cleavage of branch points in branched glycogen polymers. got7fsn_ti molecular_function owl:Class GO:0047747 biolink:NamedThing cholate-CoA ligase activity Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. got7fsn_ti choloyl coenzyme A synthetase activity|cholate thiokinase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity|cholic thiokinase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity|BAL activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity|trihydroxycoprostanoyl-CoA synthetase activity|bile acid CoA ligase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity|cholyl-CoA synthetase activity|cholate:CoA ligase (AMP-forming)|cholic acid:CoA ligase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity|bile acid coenzyme A ligase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)|choloyl-CoA synthetase activity|THCA-CoA ligase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity GO:0047477 EC:6.2.1.7|MetaCyc:CHOLATE--COA-LIGASE-RXN molecular_function owl:Class GO:0060134 biolink:NamedThing prepulse inhibition The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. got7fsn_ti pre-pulse inhibition|PPI Wikipedia:Prepulse_inhibition biological_process owl:Class GO:0032102 biolink:NamedThing negative regulation of response to external stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. got7fsn_ti inhibition of response to external stimulus|downregulation of response to external stimulus|down-regulation of response to external stimulus|down regulation of response to external stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0043354 biolink:NamedThing enucleate erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus. got7fsn_ti enucleate RBC maturation|enucleate red blood cell maturation biological_process owl:Class GO:0043249 biolink:NamedThing erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. got7fsn_ti red blood cell maturation|RBC maturation biological_process owl:Class GO:0050320 biolink:NamedThing tartrate epimerase activity Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate. got7fsn_ti tartaric racemase activity KEGG_REACTION:R02546|EC:5.1.2.5|MetaCyc:TARTRATE-EPIMERASE-RXN|RHEA:22212 molecular_function owl:Class GO:0106267 biolink:NamedThing 3,5 dichloro-THPH synthase activity Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O. got7fsn_ti hjd 2020-06-02T18:16:23Z RHEA:64360 molecular_function owl:Class GO:0016712 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. got7fsn_ti flavoprotein-linked monooxygenase activity|cytochrome p450 activity|microsomal P-450|microsomal p450 activity|substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)|xenobiotic monooxygenase activity|unspecific monooxygenase activity|flavoprotein monooxygenase activity|microsomal monooxygenase activity|cytochrome P450 CYP19|aryl hydrocarbon hydroxylase activity|aryl-4-monooxygenase activity GO:0008402|GO:0050381 Reactome:R-HSA-211966|UM-BBD_enzymeID:e0551|EC:1.14.14.- molecular_function owl:Class GO:0000331 biolink:NamedThing contractile vacuole A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. One of its functions is osmoregulatory. got7fsn_ti central bladder|central vacuole Wikipedia:Contractile_vacuole cellular_component owl:Class GO:0005773 biolink:NamedThing vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. got7fsn_ti vacuolar carboxypeptidase Y Wikipedia:Vacuole cellular_component owl:Class GO:0070444 biolink:NamedThing oligodendrocyte progenitor proliferation The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system. got7fsn_ti oligodendrocyte precursor proliferation biological_process owl:Class GO:0061351 biolink:NamedThing neural precursor cell proliferation The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. got7fsn_ti dph 2010-10-01T11:06:04Z biological_process owl:Class GO:0042296 biolink:NamedThing ISG15 transferase activity Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. got7fsn_ti ISG15 conjugating enzyme activity Reactome:R-HSA-5653754 molecular_function owl:Class GO:0019787 biolink:NamedThing ubiquitin-like protein transferase activity Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. got7fsn_ti small conjugating protein transferase activity|E3|small conjugating protein ligase activity|small protein conjugating enzyme activity|ubiquitin-like-protein ligase activity|ubiquitin-like conjugating enzyme activity|E2 GO:0008639|GO:0008640 Reactome:R-HSA-5678490|Reactome:R-HSA-688137 molecular_function owl:Class GO:0030282 biolink:NamedThing bone mineralization The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. got7fsn_ti bone calcification biological_process owl:Class GO:0031214 biolink:NamedThing biomineral tissue development Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. got7fsn_ti Wikipedia:Biomineralization biological_process owl:Class GO:0034387 biolink:NamedThing 4-aminobutyrate:pyruvate transaminase activity Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine. got7fsn_ti gamma-aminobutyric acid pyruvate transaminase activity MetaCyc:RXN-6902|RHEA:32263|EC:2.6.1.96 molecular_function owl:Class GO:0003867 biolink:NamedThing 4-aminobutyrate transaminase activity Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. got7fsn_ti beta-alanine aminotransferase|gamma-aminobutyric transaminase activity|aminobutyrate transaminase activity|GABA aminotransferase activity|GABA transferase activity|gamma-aminobutyric acid aminotransferase activity|glutamate-succinic semialdehyde transaminase activity|aminobutyrate aminotransferase activity|gamma-amino-N-butyrate transaminase activity|4-aminobutyrate aminotransferase activity|4-aminobutanoate transaminase activity|gamma-aminobutyrate transaminase activity|4-aminobutyric acid aminotransferase activity|gamma-aminobutyrate aminotransaminase activity|gamma-aminobutyric acid transaminase activity|GABA transaminase activity RHEA:23352|Reactome:R-HSA-916855|MetaCyc:GABATRANSAM-RXN molecular_function owl:Class GO:0042165 biolink:NamedThing neurotransmitter binding Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. got7fsn_ti molecular_function owl:Class GO:0005488 biolink:NamedThing binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. got7fsn_ti ligand Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. Wikipedia:Binding_(molecular) molecular_function owl:Class GO:0050083 biolink:NamedThing malyl-CoA lyase activity Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate. got7fsn_ti (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)|malyl-coenzyme A lyase activity|(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity MetaCyc:MALYL-COA-LYASE-RXN|EC:4.1.3.24|RHEA:16629 molecular_function owl:Class GO:0016833 biolink:NamedThing oxo-acid-lyase activity Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. got7fsn_ti oxo-acid lyase activity|oxoacid lyase activity EC:4.1.3.- molecular_function owl:Class GO:0050290 biolink:NamedThing sphingomyelin phosphodiesterase D activity Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+). got7fsn_ti sphingomyelinase D|sphingomyelin ceramide-phosphohydrolase activity MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN|EC:3.1.4.41|RHEA:20984|KEGG_REACTION:R02542 molecular_function owl:Class GO:0008081 biolink:NamedThing phosphoric diester hydrolase activity Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. got7fsn_ti phosphodiesterase GO:0004434|GO:0016792 EC:3.1.4.-|Reactome:R-HSA-5693578 molecular_function owl:Class GO:0002450 biolink:NamedThing B cell antigen processing and presentation The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti B-cell antigen processing and presentation|B lymphocyte antigen processing and presentation|B-lymphocyte antigen processing and presentation biological_process owl:Class GO:1902761 biolink:NamedThing positive regulation of chondrocyte development Any process that activates or increases the frequency, rate or extent of chondrocyte development. got7fsn_ti upregulation of chondrocyte development|up regulation of chondrocyte development|up-regulation of chondrocyte development|activation of chondrocyte development mr 2014-03-07T17:45:55Z biological_process owl:Class GO:0061181 biolink:NamedThing regulation of chondrocyte development Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. got7fsn_ti dph 2010-07-14T08:28:52Z biological_process owl:Class GO:0010476 biolink:NamedThing gibberellin mediated signaling pathway The series of molecular signals generated as a consequence of gibberellin stimulus. got7fsn_ti gibberellin-mediated signalling biological_process owl:Class GO:0009755 biolink:NamedThing hormone-mediated signaling pathway A series of molecular signals mediated by the detection of a hormone. got7fsn_ti hormone mediated signalling biological_process owl:Class GO:0010098 biolink:NamedThing suspensor development The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm. got7fsn_ti biological_process owl:Class GO:0047837 biolink:NamedThing D-xylose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH. got7fsn_ti D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|D-xylose:NADP+ 1-oxidoreductase activity|D-xylose:NADP+ oxidoreductase activity|D-xylose-NADP dehydrogenase activity MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN|RHEA:22000|EC:1.1.1.179|KEGG_REACTION:R01430 molecular_function owl:Class GO:0102931 biolink:NamedThing (Z,E)-alpha- farnesene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8931 molecular_function owl:Class GO:0014902 biolink:NamedThing myotube differentiation The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. got7fsn_ti biological_process owl:Class GO:0051146 biolink:NamedThing striated muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. got7fsn_ti voluntary muscle cell differentiation biological_process owl:Class GO:0000702 biolink:NamedThing oxidized base lesion DNA N-glycosylase activity Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. got7fsn_ti molecular_function owl:Class GO:0052880 biolink:NamedThing oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein. got7fsn_ti EC:1.10.9.- molecular_function owl:Class GO:0016679 biolink:NamedThing oxidoreductase activity, acting on diphenols and related substances as donors Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors EC:1.10.-.- molecular_function owl:Class GO:1990692 biolink:NamedThing trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. got7fsn_ti trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane bhm 2015-03-12T09:54:02Z biological_process owl:Class GO:0048210 biolink:NamedThing Golgi vesicle fusion to target membrane The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane. got7fsn_ti dictyosome vesicle fusion to target membrane|Golgi-derived vesicle fusion to target membrane biological_process owl:Class GO:0015638 biolink:NamedThing microcin transmembrane transporter activity Enables the transfer of a microcin from one side of a membrane to the other. got7fsn_ti microcin uptake permease activity molecular_function owl:Class GO:0042910 biolink:NamedThing xenobiotic transmembrane transporter activity Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti multidrug, alkane resistant pump activity|multidrug efflux pump activity|drug transmembrane transporter activity|drug transporter activity|multidrug transporter activity|xenobiotic transporter activity https://github.com/geneontology/go-ontology/issues/19460 GO:0015559|GO:0015564|GO:0090484|GO:0015238|GO:0015239 molecular_function owl:Class GO:0016641 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. got7fsn_ti EC:1.4.3.- molecular_function owl:Class GO:0016638 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors EC:1.4.-.- molecular_function owl:Class GO:0016054 biolink:NamedThing organic acid catabolic process The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. got7fsn_ti organic acid degradation|organic acid catabolism|organic acid breakdown biological_process owl:Class GO:0006082 biolink:NamedThing organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. got7fsn_ti organic acid metabolism biological_process owl:Class GO:0070043 biolink:NamedThing rRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine. got7fsn_ti Reactome:R-HSA-6790982 molecular_function owl:Class GO:1990834 biolink:NamedThing response to odorant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell. got7fsn_ti sl 2015-08-21T18:51:52Z biological_process owl:Class GO:0042221 biolink:NamedThing response to chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. got7fsn_ti response to chemical stimulus|response to chemical substance Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0005145 biolink:NamedThing interleukin-14 receptor binding Binding to an interleukin-14 receptor. got7fsn_ti IL-14|interleukin-14 receptor ligand molecular_function owl:Class GO:0021521 biolink:NamedThing ventral spinal cord interneuron specification The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. got7fsn_ti biological_process owl:Class GO:0048665 biolink:NamedThing neuron fate specification The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class GO:0030588 biolink:NamedThing pseudocleavage Partial constriction of the cytoplasm of a cell to form a furrow that resembles a cleavage furrow but does not complete cytokinesis. got7fsn_ti biological_process owl:Class GO:0038060 biolink:NamedThing nitric oxide-cGMP-mediated signaling pathway Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP. got7fsn_ti canonical nitric oxide signaling|NO-cGMP signaling pathway|classical nitric oxide signaling|nitric oxide-cGMP-mediated signalling pathway bf 2012-01-10T05:32:39Z biological_process owl:Class GO:0007263 biolink:NamedThing nitric oxide mediated signal transduction Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. got7fsn_ti nitric oxide-mediated signal transduction|NO-mediated signal transduction|nitric oxide signaling|NO mediated signal transduction biological_process owl:Class GO:0050594 biolink:NamedThing tabersonine 16-hydroxylase activity Catalysis of the reaction: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+). got7fsn_ti tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating) MetaCyc:1.14.13.73-RXN|EC:1.14.14.103|KEGG_REACTION:R05855|RHEA:14133 molecular_function owl:Class GO:0009418 biolink:NamedThing pilus shaft The long, slender, mid section of a pilus. got7fsn_ti fimbrial shaft cellular_component owl:Class GO:0021623 biolink:NamedThing oculomotor nerve formation The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. got7fsn_ti CN III biosynthesis|CN III formation biological_process owl:Class GO:0021603 biolink:NamedThing cranial nerve formation The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. got7fsn_ti biological_process owl:Class GO:0003209 biolink:NamedThing cardiac atrium morphogenesis The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. got7fsn_ti dph 2009-10-13T09:39:44Z biological_process owl:Class GO:1990117 biolink:NamedThing B cell receptor apoptotic signaling pathway An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell. got7fsn_ti B cell receptor extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway via BCR|extrinsic apoptotic signaling pathway via B cell antigen receptor pr 2013-06-06T15:15:17Z biological_process owl:Class GO:0035771 biolink:NamedThing interleukin-4-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-4-mediated signalling pathway|IL-4-mediated signaling pathway bf 2011-04-01T10:56:46Z biological_process owl:Class GO:0044809 biolink:NamedThing chemokine (C-C motif) ligand 17 production The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CCL17 production|thymus and activation regulated chemokine production|TARC production jl 2013-09-11T12:21:31Z biological_process owl:Class GO:0032602 biolink:NamedThing chemokine production The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. got7fsn_ti chemokine synthesis|chemokine biosynthetic process|chemokine secretion|chemokine anabolism|chemokine formation|chemokine biosynthesis|chemokine metabolic process 2009-12-18T11:26:20Z GO:0090195|GO:0042033|GO:0050755 biological_process owl:Class GO:0036501 biolink:NamedThing UFD1-NPL4 complex A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p. got7fsn_ti Npl4p-Ufd1p complex|Ufd1/Npl4 complex|UFD1L-NPLOC4 complex|Ufd1-Npl4 cofactor complex|Ufd1-Npl4 binary complex bf 2015-05-14T10:59:43Z cellular_component owl:Class GO:0071417 biolink:NamedThing cellular response to organonitrogen compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. got7fsn_ti cellular response to organic nitrogen mah 2009-12-14T04:07:27Z biological_process owl:Class GO:0071495 biolink:NamedThing cellular response to endogenous stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. mah 2009-12-18T02:25:40Z biological_process owl:Class GO:0106017 biolink:NamedThing phosphatidylinositol-3,4-bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. got7fsn_ti hjd 2017-05-10T14:08:06Z molecular_function owl:Class GO:0034593 biolink:NamedThing phosphatidylinositol bisphosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate. got7fsn_ti triphosphoinositide phosphomonoesterase activity|diphosphoinositide phosphatase activity|phosphatidylinositol-bisphosphatase activity|triphosphoinositide phosphatase activity|phosphatidyl-inositol-bisphosphate phosphatase activity molecular_function owl:Class GO:0046889 biolink:NamedThing positive regulation of lipid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. got7fsn_ti up regulation of lipid biosynthetic process|positive regulation of lipogenesis|stimulation of lipid biosynthetic process|activation of lipid biosynthetic process|positive regulation of lipid synthesis|up-regulation of lipid biosynthetic process|positive regulation of lipid formation|positive regulation of lipid biosynthesis|upregulation of lipid biosynthetic process|positive regulation of lipid anabolism biological_process owl:Class GO:0046890 biolink:NamedThing regulation of lipid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. got7fsn_ti regulation of lipid formation|regulation of lipogenesis|regulation of lipid biosynthesis|regulation of lipid synthesis|regulation of lipid anabolism biological_process owl:Class GO:0031434 biolink:NamedThing mitogen-activated protein kinase kinase binding Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase. got7fsn_ti MAPKK binding molecular_function owl:Class GO:0019901 biolink:NamedThing protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. got7fsn_ti molecular_function owl:Class GO:0022852 biolink:NamedThing glycine-gated chloride ion channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts. got7fsn_ti molecular_function owl:Class GO:0022824 biolink:NamedThing transmitter-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. got7fsn_ti ionotropic neurotransmitter receptor activity molecular_function owl:Class GO:0010445 biolink:NamedThing nuclear dicing body A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes. got7fsn_ti D body cellular_component owl:Class GO:0016604 biolink:NamedThing nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. got7fsn_ti NIF_Subcellular:sao505137457 cellular_component owl:Class GO:0034554 biolink:NamedThing 3,3',5-tribromobisphenol A reductive dehalogenase activity Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr. got7fsn_ti UM-BBD_reactionID:r0842|EC:1.97.1.- molecular_function owl:Class GO:1990864 biolink:NamedThing response to growth hormone-releasing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins. got7fsn_ti response to sermorelin|response to somatoliberin|response to somatorelin|response to GHRF|response to GRF|response to somatocrinin|response to growth hormone-releasing factor sl 2015-09-25T14:45:31Z biological_process owl:Class GO:0009163 biolink:NamedThing nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). got7fsn_ti nucleoside formation|nucleoside synthesis|nucleoside biosynthesis|nucleoside anabolism biological_process owl:Class GO:0034404 biolink:NamedThing nucleobase-containing small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. got7fsn_ti nucleobase, nucleoside and nucleotide formation|nucleobase, nucleoside and nucleotide biosynthesis|nucleobase, nucleoside and nucleotide anabolism|nucleobase, nucleoside and nucleotide synthesis biological_process owl:Class GO:0097435 biolink:NamedThing supramolecular fiber organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. got7fsn_ti fibril organization|extracellular fibril organization|fibril organisation|extracellular fibril organization and biogenesis|extracellular fibril organisation pr 2012-11-27T15:46:25Z GO:0043206 biological_process owl:Class GO:0016043 biolink:NamedThing cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. got7fsn_ti cellular component organization at cellular level|cellular component organisation in other organism|cell organization and biogenesis|cellular component organisation at cellular level|cellular component organization in other organism|cell organisation GO:0044235|GO:0071842 biological_process owl:Class GO:0061521 biolink:NamedThing hepatic stellate cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell. got7fsn_ti dph 2013-04-18T13:36:08Z biological_process owl:Class GO:0018218 biolink:NamedThing peptidyl-cysteine phosphorylation The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine. got7fsn_ti RESID:AA0034 biological_process owl:Class GO:1990315 biolink:NamedThing Mcs4 RR-MAPKKK complex A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress. got7fsn_ti In S. pombe it consists of Mpr1, Tdh1, Mcs4, Win1, Wis4 and Wis1. al 2014-03-14T09:59:45Z cellular_component owl:Class GO:0099589 biolink:NamedThing serotonin receptor activity Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. got7fsn_ti molecular_function owl:Class GO:0050740 biolink:NamedThing protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine. got7fsn_ti RESID:AA0349 biological_process owl:Class GO:0060407 biolink:NamedThing negative regulation of penile erection Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. got7fsn_ti biological_process owl:Class GO:0015049 biolink:NamedThing methane monooxygenase activity Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O. got7fsn_ti methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)|methane hydroxylase activity UM-BBD_enzymeID:e0007|KEGG_REACTION:R01143|MetaCyc:METHANE-MONOOXYGENASE-RXN|EC:1.14.13.25|KEGG_REACTION:R01142 molecular_function owl:Class GO:0009727 biolink:NamedThing detection of ethylene stimulus The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of ethene stimulus|perception of ethylene stimulus|detection of ethene stimulus biological_process owl:Class GO:0009723 biolink:NamedThing response to ethylene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. got7fsn_ti response to ethylene stimulus|response to ethene stimulus biological_process owl:Class GO:0036176 biolink:NamedThing response to neutral pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti bf 2012-03-29T01:38:00Z biological_process owl:Class GO:0046780 biolink:NamedThing suppression by virus of host mRNA splicing Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production. got7fsn_ti suppression by virus of host splicing factor activity|viral inhibition of host mRNA splicing|negative regulation by virus of host mRNA splicing|viral dispersion of host splicing factors GO:0046781 biological_process owl:Class GO:0033119 biolink:NamedThing negative regulation of RNA splicing Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. got7fsn_ti biological_process owl:Class GO:0097478 biolink:NamedThing leaflet of membrane bilayer Any of the two layers of lipid molecules that constitute a membrane. got7fsn_ti membrane leaflet pr 2013-05-07T14:24:37Z cellular_component owl:Class GO:0061303 biolink:NamedThing cornea development in camera-type eye The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. got7fsn_ti dph 2010-09-14T02:09:08Z biological_process owl:Class GO:0061150 biolink:NamedThing renal system segmentation The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis. got7fsn_ti urinary tract segmentation dph 2010-06-02T09:23:01Z biological_process owl:Class GO:0080173 biolink:NamedThing male-female gamete recognition during double fertilization forming a zygote and endosperm The initial contact step made between the male gamete and the female gamete during double fertilization forming a zygote and endosperm. An example can be found in Arabidopsis thaliana. got7fsn_ti gamete recognition|male-female gamete recognition dhl 2011-04-26T04:58:58Z biological_process owl:Class GO:0009988 biolink:NamedThing cell-cell recognition Cell recognition between cells. May involve the formation of specialized cell junctions. got7fsn_ti biological_process owl:Class GO:0043849 biolink:NamedThing Ras palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins. got7fsn_ti Ras protein acyltransferase activity|DHHC cysteine-rich domain-containing protein ERF2|palmitoyltransferase ERF2|ERF2 molecular_function owl:Class GO:0019706 biolink:NamedThing protein-cysteine S-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]. got7fsn_ti protein-cysteine S-palmitoleyltransferase activity EC:2.3.1.225|RHEA:36683|Reactome:R-HSA-9647982|Reactome:R-HSA-5682084|Reactome:R-HSA-9021072 molecular_function owl:Class GO:0018096 biolink:NamedThing peptide cross-linking via S-(2-aminovinyl)-D-cysteine The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine. got7fsn_ti RESID:AA0204 biological_process owl:Class GO:0045196 biolink:NamedThing establishment or maintenance of neuroblast polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. got7fsn_ti establishment and/or maintenance of neuroblast cell polarity GO:0043342|GO:0043339 biological_process owl:Class GO:0007163 biolink:NamedThing establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. got7fsn_ti cell polarity|establishment and/or maintenance of cell polarity|establishment and/or maintenance of cell polarization GO:0030467|GO:0030012 biological_process owl:Class GO:0035907 biolink:NamedThing dorsal aorta development The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. got7fsn_ti bf 2011-06-24T11:07:01Z biological_process owl:Class GO:0035904 biolink:NamedThing aorta development The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. got7fsn_ti bf 2011-06-24T11:00:07Z biological_process owl:Class GO:0003858 biolink:NamedThing 3-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH. got7fsn_ti D-beta-hydroxybutyrate dehydrogenase activity MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN|EC:1.1.1.30|KEGG_REACTION:R01361|Reactome:R-HSA-73920|Reactome:R-HSA-73912|Reactome:R-HSA-5696457|RHEA:20521 molecular_function owl:Class GO:0051337 biolink:NamedThing amitosis Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation. got7fsn_ti Remak nuclear division|direct nuclear division biological_process owl:Class GO:0000280 biolink:NamedThing nuclear division The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. got7fsn_ti karyokinesis biological_process owl:Class GO:0007377 biolink:NamedThing germ-band extension Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further. got7fsn_ti biological_process owl:Class GO:0048598 biolink:NamedThing embryonic morphogenesis The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. got7fsn_ti embryonic anatomical structure morphogenesis GO:0048828 biological_process owl:Class GO:2000195 biolink:NamedThing negative regulation of female gonad development Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. got7fsn_ti negative regulation of ovary development|negative regulation of ovarian development yaf 2010-10-19T10:45:38Z biological_process owl:Class GO:0051093 biolink:NamedThing negative regulation of developmental process Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). got7fsn_ti downregulation of developmental process|inhibition of developmental process|down regulation of developmental process|down-regulation of developmental process biological_process owl:Class GO:0060472 biolink:NamedThing positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol. got7fsn_ti positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration biological_process owl:Class GO:0045956 biolink:NamedThing positive regulation of calcium ion-dependent exocytosis Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. got7fsn_ti up regulation of calcium ion-dependent exocytosis|activation of calcium ion-dependent exocytosis|up-regulation of calcium ion-dependent exocytosis|upregulation of calcium ion-dependent exocytosis|stimulation of calcium ion-dependent exocytosis biological_process owl:Class GO:0031803 biolink:NamedThing type 6 metabotropic glutamate receptor binding Binding to a type 6 metabotropic glutamate receptor. got7fsn_ti type 6 metabotropic glutamate receptor ligand molecular_function owl:Class GO:0035256 biolink:NamedThing G protein-coupled glutamate receptor binding Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor). got7fsn_ti metabotropic glutamate receptor binding|G-protein coupled glutamate receptor binding molecular_function owl:Class GO:0102063 biolink:NamedThing beta-curcumene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (-)-beta-curcumene. got7fsn_ti MetaCyc:RXN-10598 molecular_function owl:Class GO:0003417 biolink:NamedThing growth plate cartilage development The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. got7fsn_ti dph 2009-12-22T08:57:42Z biological_process owl:Class GO:0060351 biolink:NamedThing cartilage development involved in endochondral bone morphogenesis The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. got7fsn_ti biological_process owl:Class GO:0035888 biolink:NamedThing isoguanine deaminase activity Catalysis of the reaction: isoguanine + H2O = xanthine + NH3. got7fsn_ti 2-oxoadenine deaminase activity|2-hydroxyadenine deaminase activity bf 2011-06-14T02:15:53Z molecular_function owl:Class GO:1901991 biolink:NamedThing negative regulation of mitotic cell cycle phase transition Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition. got7fsn_ti downregulation of mitotic cell cycle phase transition|inhibition of mitotic cell cycle phase transition|down regulation of mitotic cell cycle phase transition|down-regulation of mitotic cell cycle phase transition jl 2013-03-19T16:14:46Z biological_process owl:Class GO:0098622 biolink:NamedThing selenodiglutathione-disulfide reductase activity Catalysis of the reaction: H+ + selenodiglutathione + NADPH => gluthathioselenol + glutathione + NADP+. got7fsn_ti RHEA:34927|Reactome:R-HSA-2408542 molecular_function owl:Class GO:0015036 biolink:NamedThing disulfide oxidoreductase activity Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. got7fsn_ti disulphide oxidoreductase activity Reactome:R-HSA-1222417|Reactome:R-HSA-1222644|Reactome:R-HSA-264997|Reactome:R-HSA-1222690|Reactome:R-HSA-1222655 molecular_function owl:Class GO:0071278 biolink:NamedThing cellular response to cesium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus. got7fsn_ti cellular response to cesium mah 2009-12-10T03:55:44Z biological_process owl:Class GO:0010164 biolink:NamedThing response to cesium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus. got7fsn_ti response to cesium biological_process owl:Class GO:0014001 biolink:NamedThing sclerenchyma cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable. got7fsn_ti biological_process owl:Class GO:0052104 biolink:NamedThing induction by symbiont of host systemic acquired resistance Any process in which a symbiont activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti activation by organism of SAR in host|induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction|activation by organism of systemic acquired resistance in host|up regulation by symbiont of systemic acquired resistance in host|positive regulation by symbiont of systemic acquired resistance in host|upregulation by symbiont of systemic acquired resistance in host|positive regulation by symbiont of host systemic acquired resistance|induction by symbiont of systemic acquired resistance in host|stimulation by symbiont of systemic acquired resistance in host|up-regulation by symbiont of systemic acquired resistance in host|positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction|induction by organism of SAR in host GO:0052535|GO:0052537|GO:0052289 biological_process owl:Class GO:0052160 biolink:NamedThing modulation by symbiont of host systemic acquired resistance Any process in which a symbiont modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction|modulation by symbiont of systemic acquired resistance in host GO:0052299 biological_process owl:Class GO:0019799 biolink:NamedThing tubulin N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine. got7fsn_ti acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity|alpha-tubulin acetyltransferase activity|alpha-tubulin N-acetyltransferase activity|alpha-tubulin acetylase activity|acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity|TAT activity|tubulin acetyltransferase activity|acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN|RHEA:15277|EC:2.3.1.108 molecular_function owl:Class GO:0061733 biolink:NamedThing peptide-lysine-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide. got7fsn_ti dph 2015-09-10T10:22:19Z Reactome:R-HSA-9620515|Reactome:R-HSA-9617758|Reactome:R-HSA-9626945|Reactome:R-HSA-8951966|Reactome:R-HSA-6811508 molecular_function owl:Class GO:0070078 biolink:NamedThing histone H3-R2 demethylation The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone. got7fsn_ti biological_process owl:Class GO:0070077 biolink:NamedThing histone arginine demethylation The modification of a histone by the removal of a methyl group from an arginine residue. got7fsn_ti biological_process owl:Class GO:0045184 biolink:NamedThing establishment of protein localization The directed movement of a protein to a specific location. got7fsn_ti establishment of protein localisation|protein recruitment|protein positioning biological_process owl:Class GO:0051234 biolink:NamedThing establishment of localization Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. got7fsn_ti establishment of localisation biological_process owl:Class GO:0022871 biolink:NamedThing protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti sorbose PTS transporter activity https://github.com/geneontology/go-ontology/issues/17289 EC:2.7.1.206|RHEA:49296 molecular_function owl:Class GO:0019194 biolink:NamedThing sorbose transmembrane transporter activity Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. got7fsn_ti sorbose porter activity GO:0019193 molecular_function owl:Class GO:0071357 biolink:NamedThing cellular response to type I interferon Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. got7fsn_ti cellular response to type I IFN mah 2009-12-11T02:51:47Z biological_process owl:Class GO:0034340 biolink:NamedThing response to type I interferon Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. got7fsn_ti response to type I IFN biological_process owl:Class GO:0102169 biolink:NamedThing pyocyanin hydroxylase activity Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ <=> pyocyanin + NAD + carbon dioxide + H2O. got7fsn_ti MetaCyc:RXN-11898|RHEA:48976 molecular_function owl:Class GO:0052249 biolink:NamedThing modulation of RNA levels in other organism involved in symbiotic interaction The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modulation of RNA levels in other organism during symbiotic interaction biological_process owl:Class GO:0051817 biolink:NamedThing modulation of process of other organism involved in symbiotic interaction The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti regulation of physiology of other organism during symbiotic interaction|regulation of morphology of other organism during symbiotic interaction|modification of morphology or physiology of other organism involved in symbiotic interaction|regulation of physiological process in other organism during symbiotic interaction|modulation of morphology or physiology of other organism during symbiotic interaction|regulation of morphology or physiology of other organism during symbiotic interaction|modification of morphology or physiology of other organism during symbiotic interaction|modulation of biological process of other organism involved in symbiotic interaction https://github.com/geneontology/go-ontology/issues/18605 biological_process owl:Class GO:0051660 biolink:NamedThing establishment of centrosome localization The directed movement of the centrosome to a specific location. got7fsn_ti establishment of centrosome localisation|centrosome positioning biological_process owl:Class GO:0051649 biolink:NamedThing establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. got7fsn_ti establishment of intracellular localization|positioning within cell|establishment of localization within cell|establishment of localisation in cell|establishment of cellular localization biological_process owl:Class GO:0033763 biolink:NamedThing proline 3-hydroxylase activity Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2. got7fsn_ti P-3-H|L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity RHEA:20265|EC:1.14.11.28|MetaCyc:1.14.11.28-RXN molecular_function owl:Class GO:0018650 biolink:NamedThing styrene monooxygenase activity Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide. got7fsn_ti UM-BBD_reactionID:r0225|EC:1.14.13.- molecular_function owl:Class GO:0005360 biolink:NamedThing insulin-responsive glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. got7fsn_ti insulin-responsive hydrogen:glucose transporter activity|transepithelial hydrogen/glucose transporter activity|insulin-responsive hydrogen:glucose symporter activity molecular_function owl:Class GO:0005356 biolink:NamedThing glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. got7fsn_ti hydrogen:glucose transporter activity|transepithelial hydrogen:glucose symporter activity|transepithelial hydrogen:glucose transporter activity|hydrogen:glucose symporter activity|transepithelial hydrogen/glucose transporter activity GO:0005361 molecular_function owl:Class GO:0021564 biolink:NamedThing vagus nerve development The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. got7fsn_ti cranial nerve X development|cranial nerve 10 development|CN X development biological_process owl:Class GO:0021545 biolink:NamedThing cranial nerve development The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. got7fsn_ti biological_process owl:Class GO:1990571 biolink:NamedThing meiotic centromere clustering The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I. got7fsn_ti centromere clustering during meiosis|homologous chromosome movement towards spindle pole in meiosis I prometaphase mah 2014-12-02T11:25:37Z biological_process owl:Class GO:0016344 biolink:NamedThing meiotic chromosome movement towards spindle pole The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis. got7fsn_ti chromosome movement towards spindle pole during meiosis|meiotic chromosome movement|chromosome migration to spindle pole during meiosis|meiotic chromosome movement to spindle pole biological_process owl:Class GO:2000945 biolink:NamedThing regulation of amylopectin catabolic process Any process that modulates the frequency, rate or extent of amylopectin catabolic process. got7fsn_ti regulation of Amylopectin catabolism tt 2011-08-01T02:15:22Z biological_process owl:Class GO:0031329 biolink:NamedThing regulation of cellular catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. got7fsn_ti regulation of cellular degradation|regulation of cellular catabolism|regulation of cellular breakdown biological_process owl:Class GO:0007157 biolink:NamedThing heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. got7fsn_ti agglutination biological_process owl:Class GO:0051994 biolink:NamedThing P-methyltransferase activity Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule. got7fsn_ti ai 2010-07-16T04:39:34Z EC:2.1.1.- molecular_function owl:Class GO:0030289 biolink:NamedThing protein phosphatase 4 complex A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits. got7fsn_ti cellular_component owl:Class GO:0007527 biolink:NamedThing adult somatic muscle development The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class GO:0007525 biolink:NamedThing somatic muscle development The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle. got7fsn_ti biological_process owl:Class GO:0030410 biolink:NamedThing nicotianamine synthase activity Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine. got7fsn_ti S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity EC:2.5.1.43|KEGG_REACTION:R00075|MetaCyc:2.5.1.43-RXN|RHEA:16481 molecular_function owl:Class GO:0047220 biolink:NamedThing galactosylxylosylprotein 3-beta-galactosyltransferase activity Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP. got7fsn_ti galactosyltransferase II activity|uridine diphosphogalactose-galactosylxylose galactosyltransferase activity|UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity|UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity RHEA:11780|Reactome:R-HSA-1889978|MetaCyc:2.4.1.134-RXN|Reactome:R-HSA-4420365|EC:2.4.1.134 molecular_function owl:Class GO:0043844 biolink:NamedThing ADP-specific phosphofructokinase activity Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate. got7fsn_ti ADP:D-fructose-6-phosphate 1-phosphotransferase activity|ADP-dependent phosphofructokinase activity|ADP-6-phosphofructokinase activity|ADP-Pfk activity EC:2.7.1.146|RHEA:20105 molecular_function owl:Class GO:0016773 biolink:NamedThing phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). got7fsn_ti Reactome:R-HSA-2161193|EC:2.7.1.- molecular_function owl:Class GO:0102447 biolink:NamedThing rhamnetin 3'-O-methyltransferase activity Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-13933 molecular_function owl:Class GO:0070941 biolink:NamedThing eisosome assembly The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane. got7fsn_ti mah 2009-09-30T02:49:30Z biological_process owl:Class GO:0022607 biolink:NamedThing cellular component assembly The aggregation, arrangement and bonding together of a cellular component. got7fsn_ti cellular component assembly at cellular level|cell structure assembly GO:0071844 biological_process owl:Class GO:0002477 biolink:NamedThing antigen processing and presentation of exogenous peptide antigen via MHC class Ib The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. got7fsn_ti exogenous peptide antigen processing and presentation via MHC class Ib biological_process owl:Class GO:0002478 biolink:NamedThing antigen processing and presentation of exogenous peptide antigen The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. got7fsn_ti exogenous peptide antigen processing and presentation biological_process owl:Class GO:0016925 biolink:NamedThing protein sumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. got7fsn_ti Smt3-protein conjugation|small ubiquitin-related protein 1 conjugation|protein sumolation|SUMO-protein conjugation|sumoylation|Smt3p-protein conjugation GO:0016927|GO:0006485|GO:0019951|GO:0019947 Wikipedia:SUMO_protein biological_process owl:Class GO:0032446 biolink:NamedThing protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. got7fsn_ti biological_process owl:Class GO:0061541 biolink:NamedThing rhabdomere morphogenesis The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments. got7fsn_ti dph 2013-06-24T07:59:25Z biological_process owl:Class GO:0048812 biolink:NamedThing neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. got7fsn_ti neurite formation|neurite morphogenesis|neurite growth|neurite biosynthesis biological_process owl:Class GO:0044753 biolink:NamedThing amphisome Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes. got7fsn_ti jl 2012-11-27T15:35:25Z cellular_component owl:Class GO:0005776 biolink:NamedThing autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. got7fsn_ti initial autophagic vacuole|autophagic vacuole NIF_Subcellular:sao8663416959 cellular_component owl:Class GO:0042404 biolink:NamedThing thyroid hormone catabolic process The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. got7fsn_ti thyroid hormone breakdown|thyroid hormone catabolism|thyroid hormone degradation biological_process owl:Class GO:0042219 biolink:NamedThing cellular modified amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. got7fsn_ti cellular amino acid derivative catabolism|cellular modified amino acid breakdown|cellular amino acid derivative degradation|cellular modified amino acid catabolism|cellular modified amino acid degradation|modified amino acid catabolic process|cellular amino acid derivative catabolic process|amino acid derivative catabolic process|modified amino acid catabolism|cellular amino acid derivative breakdown biological_process owl:Class GO:0060920 biolink:NamedThing cardiac pacemaker cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. got7fsn_ti pacemaker cell differentiation dph 2009-09-29T11:01:31Z biological_process owl:Class GO:0055007 biolink:NamedThing cardiac muscle cell differentiation The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. got7fsn_ti cardiomyocyte differentiation|heart muscle cell differentiation biological_process owl:Class GO:0009626 biolink:NamedThing plant-type hypersensitive response The rapid, localized death of plant cells in response to invasion by a pathogen. got7fsn_ti plant hypersensitive response|HR-PCD|HR Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. biological_process owl:Class GO:0052848 biolink:NamedThing inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+. got7fsn_ti ai 2011-12-05T11:02:23Z MetaCyc:RXN-10976 molecular_function owl:Class GO:0052841 biolink:NamedThing inositol bisdiphosphate tetrakisphosphate diphosphatase activity Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate. got7fsn_ti ai 2011-11-29T04:14:22Z Reactome:R-HSA-1855165|Reactome:R-HSA-2023973 molecular_function owl:Class GO:0038137 biolink:NamedThing ERBB4-EGFR signaling pathway A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti HER1-HER4 signaling pathway|ERBB1-ERBB4 signaling pathway|ERBB4-EGFR signalling pathway bf 2012-03-30T11:30:30Z biological_process owl:Class GO:0007173 biolink:NamedThing epidermal growth factor receptor signaling pathway A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti ERBB1 signaling pathway|EGF receptor signalling pathway|EGF receptor signaling pathway|EGFR signaling pathway|receptor tyrosine-protein kinase erbB-1 signaling pathway|epidermal growth factor receptor signalling pathway biological_process owl:Class GO:0090032 biolink:NamedThing negative regulation of steroid hormone biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. got7fsn_ti tb 2009-08-03T10:41:35Z biological_process owl:Class GO:0032353 biolink:NamedThing negative regulation of hormone biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. got7fsn_ti down regulation of hormone biosynthetic process|downregulation of hormone biosynthetic process|inhibition of hormone biosynthetic process|down-regulation of hormone biosynthetic process biological_process owl:Class GO:0102879 biolink:NamedThing (+)-thujopsene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-thujopsene + diphosphoric acid. got7fsn_ti RHEA:30375|EC:4.2.3.79|MetaCyc:RXN-8418 molecular_function owl:Class GO:0060436 biolink:NamedThing bronchiole morphogenesis The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. got7fsn_ti biological_process owl:Class GO:0033749 biolink:NamedThing histone H3-methyl-arginine-3 demethylase activity Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone demethylase activity (H4-R3 specific)|histone H3R3me demethylase activity https://github.com/geneontology/go-ontology/issues/21089 molecular_function owl:Class GO:0032452 biolink:NamedThing histone demethylase activity Catalysis of the removal of a methyl group from a histone. got7fsn_ti Reactome:R-HSA-5661116|Reactome:R-HSA-5661114|Reactome:R-HSA-5661125|Reactome:R-HSA-5625797|Reactome:R-HSA-5661120|Reactome:R-HSA-5661115|Reactome:R-HSA-4722133|Reactome:R-HSA-3214912|Reactome:R-HSA-5661121|Reactome:R-HSA-5661124|Reactome:R-HSA-5661122|Reactome:R-HSA-4724279|Reactome:R-HSA-4754187|Reactome:R-HSA-4754181|Reactome:R-HSA-5625848|Reactome:R-HSA-4724284|Reactome:R-HSA-5625870|Reactome:R-HSA-5423117|Reactome:R-HSA-5661123|Reactome:R-HSA-4754176 molecular_function owl:Class GO:0023059 biolink:NamedThing positive adaptation of signaling pathway The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. got7fsn_ti positive adaptation of signalling pathway 2010-02-16T09:30:50Z biological_process owl:Class GO:0075039 biolink:NamedThing establishment of turgor in appressorium The process in which hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti generation of turgor in appressorium|formation of turgor in appressorium|establishment of turgor in symbiont appressorium on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class GO:0044111 biolink:NamedThing formation of structure involved in a symbiotic process The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction. got7fsn_ti development of symbiont during interaction with host|development involved in symbiotic interaction|development during symbiotic interaction|development on or near surface of other organism during symbiotic interaction|development of symbiont involved in interaction with host|development on or near surface of other organism involved in symbiotic interaction https://github.com/geneontology/go-ontology/issues/20305 jl 2009-07-30T02:26:46Z GO:0044152|GO:0044115 biological_process owl:Class GO:0045776 biolink:NamedThing negative regulation of blood pressure Any process in which the force of blood traveling through the circulatory system is decreased. got7fsn_ti down regulation of blood pressure|downregulation of blood pressure|inhibition of blood pressure|down-regulation of blood pressure biological_process owl:Class GO:0047800 biolink:NamedThing cysteamine dioxygenase activity Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine. got7fsn_ti cysteamine oxygenase activity|persulfurase activity|cysteamine:oxygen oxidoreductase activity|2-aminoethanethiol:oxygen oxidoreductase activity EC:1.13.11.19|RHEA:14409|Reactome:R-HSA-6814153|MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN|KEGG_REACTION:R02467 molecular_function owl:Class GO:0016461 biolink:NamedThing unconventional myosin complex A portmanteau term for myosins other than myosin II. got7fsn_ti non-muscle myosin Note that this term is retained because it is widely used by biologists. GO:0005860 cellular_component owl:Class GO:0016459 biolink:NamedThing myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. got7fsn_ti cellular_component owl:Class GO:0036265 biolink:NamedThing RNA (guanine-N7)-methylation The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule. got7fsn_ti bf 2012-06-25T10:28:25Z biological_process owl:Class GO:0001510 biolink:NamedThing RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. got7fsn_ti biological_process owl:Class GO:0070001 biolink:NamedThing aspartic-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. got7fsn_ti molecular_function owl:Class GO:0008233 biolink:NamedThing peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. got7fsn_ti protease activity|peptidase activity, acting on L-amino acid peptides|peptidase activity, acting on D-amino acid peptides|proteinase activity|peptide hydrolase activity|hydrolase, acting on peptide bonds GO:0070010|GO:0070011 Reactome:R-HSA-5685902|EC:3.4.-.-|Reactome:R-HSA-5655483|Reactome:R-HSA-376149|Reactome:R-HSA-3065959|Reactome:R-HSA-3139027|Reactome:R-HSA-205112|Reactome:R-HSA-3065958|Reactome:R-HSA-6803060|Reactome:R-HSA-3000243|Reactome:R-HSA-4167501|Reactome:R-HSA-5693319|Reactome:R-HSA-448678|Reactome:R-HSA-5684864 molecular_function owl:Class GO:0016059 biolink:NamedThing deactivation of rhodopsin mediated signaling The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon). got7fsn_ti rod response recovery|deactivation of rhodopsin mediated signalling biological_process owl:Class GO:0022400 biolink:NamedThing regulation of rhodopsin mediated signaling pathway Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. got7fsn_ti regulation of rhodopsin mediated signalling biological_process owl:Class GO:0018554 biolink:NamedThing 1,2-dihydroxynaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached. got7fsn_ti UM-BBD_enzymeID:e0255|RHEA:27310|EC:1.13.11.56 molecular_function owl:Class GO:0060805 biolink:NamedThing negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast. got7fsn_ti dph 2009-08-06T01:58:25Z biological_process owl:Class GO:0060806 biolink:NamedThing negative regulation of cell differentiation involved in embryonic placenta development Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state. got7fsn_ti dph 2009-08-06T02:02:18Z biological_process owl:Class GO:0003916 biolink:NamedThing DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. got7fsn_ti GO:0009387 EC:5.6.2.- molecular_function owl:Class GO:0047123 biolink:NamedThing quinoline-4-carboxylate 2-oxidoreductase activity Catalysis of the reaction: A + H(2)O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2). got7fsn_ti quinoline-4-carboxylic acid 2-oxidoreductase activity|quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating) KEGG_REACTION:R05183|RHEA:14949|EC:1.3.99.19|MetaCyc:1.3.99.19-RXN molecular_function owl:Class GO:0016627 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the CH-CH group of donors, other acceptors EC:1.3.-.-|Reactome:R-HSA-2995334|Reactome:R-HSA-9661710 molecular_function owl:Class GO:0003859 biolink:NamedThing 3-hydroxybutyryl-CoA dehydratase activity Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O. got7fsn_ti enoyl coenzyme A hydrase (D)|crotonase activity|D-3-hydroxybutyryl-CoA dehydratase activity|(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity|(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)|D-3-hydroxybutyryl coenzyme A dehydratase activity RHEA:17849|KEGG_REACTION:R03027|MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN|EC:4.2.1.55 molecular_function owl:Class GO:0018106 biolink:NamedThing peptidyl-histidine phosphorylation The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). got7fsn_ti RESID:AA0036|RESID:AA0035 biological_process owl:Class GO:0018202 biolink:NamedThing peptidyl-histidine modification The modification of peptidyl-histidine. got7fsn_ti biological_process owl:Class GO:0005610 biolink:NamedThing laminin-5 complex A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains. got7fsn_ti laminin-3A32 complex|laminin-332 complex|laminin-5A complex cellular_component owl:Class GO:0023024 biolink:NamedThing MHC class I protein complex binding Binding to a class I major histocompatibility complex. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class GO:0023023 biolink:NamedThing MHC protein complex binding Binding to a major histocompatibility complex. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class GO:0055115 biolink:NamedThing entry into diapause The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. got7fsn_ti Wikipedia:Diapause biological_process owl:Class GO:0008966 biolink:NamedThing phosphoglucosamine mutase activity Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. got7fsn_ti D-glucosamine 1,6-phosphomutase activity|alpha-D-glucosamine 1,6-phosphomutase activity MetaCyc:5.4.2.10-RXN|RHEA:23424|EC:5.4.2.10|KEGG_REACTION:R02060 molecular_function owl:Class GO:0016868 biolink:NamedThing intramolecular transferase activity, phosphotransferases Catalysis of the transfer of a phosphate group from one position to another within a single molecule. got7fsn_ti phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers|phosphomutase activity GO:0016777 EC:5.4.2.- molecular_function owl:Class GO:0102626 biolink:NamedThing parthenolide synthase activity Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> parthenolide + NADP(3-) + H2O. got7fsn_ti MetaCyc:RXN-15531 molecular_function owl:Class GO:0010101 biolink:NamedThing post-embryonic root morphogenesis The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed. got7fsn_ti biological_process owl:Class GO:0045766 biolink:NamedThing positive regulation of angiogenesis Any process that activates or increases angiogenesis. got7fsn_ti up-regulation of angiogenesis|activation of angiogenesis|stimulation of angiogenesis|up regulation of angiogenesis|upregulation of angiogenesis biological_process owl:Class GO:1904018 biolink:NamedThing positive regulation of vasculature development Any process that activates or increases the frequency, rate or extent of vasculature development. got7fsn_ti up regulation of vasculature development|positive regulation of vascular system development|up-regulation of vascular system development|upregulation of vascular system development|up regulation of vascular system development|upregulation of vasculature development|activation of vascular system development|activation of vasculature development|up-regulation of vasculature development sl 2015-03-06T22:17:04Z biological_process owl:Class GO:0039688 biolink:NamedThing viral double stranded DNA replication via reverse transcription A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. got7fsn_ti RNA-dependent viral DNA replication|dsDNA replication via RNA intermediate|viral RNA-dependent DNA replication bf 2013-10-17T15:00:08Z VZ:1938 biological_process owl:Class GO:0039693 biolink:NamedThing viral DNA genome replication The replication of a viral DNA genome. got7fsn_ti DNA-dependent viral DNA replication|viral DNA-dependent DNA replication|viral DNA replication bf 2013-10-23T15:22:31Z GO:0039681 biological_process owl:Class GO:0009900 biolink:NamedThing dehiscence The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it. got7fsn_ti Wikipedia:Dehiscence_(botany) biological_process owl:Class GO:0022414 biolink:NamedThing reproductive process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. got7fsn_ti single organism reproductive process jl 2012-09-19T15:56:06Z GO:0044702 biological_process owl:Class GO:0036503 biolink:NamedThing ERAD pathway The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. got7fsn_ti ER-associated degradation pathway|endoplasmic reticulum-associated protein degradation pathway|protein degradation by ERAD|endoplasmic reticulum-associated degradation ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct. bf 2015-05-14T11:43:06Z biological_process owl:Class GO:0042812 biolink:NamedThing pheromone catabolic process The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. got7fsn_ti pheromone breakdown|pheromone degradation|pheromone catabolism GO:0007327|GO:0046614 biological_process owl:Class GO:0042810 biolink:NamedThing pheromone metabolic process The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. got7fsn_ti pheromone metabolism biological_process owl:Class GO:0072497 biolink:NamedThing mesenchymal stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti mah 2010-12-15T12:59:30Z biological_process owl:Class GO:0048863 biolink:NamedThing stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. got7fsn_ti Wikipedia:Stem_cell_differentiation biological_process owl:Class GO:0140658 biolink:NamedThing ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. got7fsn_ti nucleosome-dependent ATPase activity|ATP hydrolysis-dependent chromatin remodeler activity|nucleosome-activated ATPase activity|ATPase-dependent chromatin remodeler activity https://github.com/geneontology/go-ontology/issues/21786|https://github.com/geneontology/go-ontology/issues/6075|https://github.com/geneontology/go-ontology/issues/21609 pg 2021-06-15T13:57:18Z GO:0070615 molecular_function owl:Class GO:0002426 biolink:NamedThing immunoglobulin production in mucosal tissue The synthesis and release of immunoglobulin in the mucosal tissue. got7fsn_ti antibody production in mucosal tissue Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class GO:0002381 biolink:NamedThing immunoglobulin production involved in immunoglobulin-mediated immune response The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti immunoglobulin production during immune response|immunoglobulin production involved in immune response|immunoglobulin biosynthetic process involved in immune response|immunoglobulin production involved in immunoglobulin mediated immune response|antibody secretion during immune response|immunoglobulin secretion involved in immune response|antibody production during immune response Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0002380|GO:0002379 biological_process owl:Class GO:0047455 biolink:NamedThing 16-alpha-hydroxyprogesterone dehydratase activity Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone. got7fsn_ti 16-alpha-dehydroxylase activity|16alpha-dehydroxylase activity|16-alpha-hydroxyprogesterone dehydroxylase activity|16alpha-hydroxyprogesterone dehydratase activity|16alpha-hydroxyprogesterone dehydroxylase activity|hydroxyprogesterone dehydroxylase activity|16alpha-hydroxyprogesterone hydro-lyase activity|16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)|16-dehydroprogesterone hydratase activity GO:0047523 RHEA:12584|EC:4.2.1.98|MetaCyc:4.2.1.98-RXN molecular_function owl:Class GO:0034414 biolink:NamedThing tRNA 3'-trailer cleavage, endonucleolytic Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. got7fsn_ti tRNA 3'-end cleavage, endonucleolytic|endonucleolytic tRNA 3'-end cleavage|endonucleolytic tRNA 3'-trailer cleavage biological_process owl:Class GO:0042779 biolink:NamedThing tRNA 3'-trailer cleavage Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. got7fsn_ti removal of tRNA 3'-trailer sequence|tRNA 3'-end cleavage biological_process owl:Class GO:0008745 biolink:NamedThing N-acetylmuramoyl-L-alanine amidase activity Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. got7fsn_ti acetylmuramoyl-alanine amidase activity|N-acylmuramyl-L-alanine amidase activity|N-acetylmuramylalanine amidase activity|N-acetylmuramoyl-L-alanine amidase type II|N-acetylmuramic acid L-alanine amidase activity|acetylmuramyl-alanine amidase activity|acetylmuramyl-L-alanine amidase activity|N-acetylmuramyl-L-alanine amidase activity|N-acetylmuramoyl-L-alanine amidase type I EC:3.5.1.28|MetaCyc:3.5.1.28-RXN|Reactome:R-HSA-6799977 molecular_function owl:Class GO:0018629 biolink:NamedThing 2-hydroxyquinoline 5,6-dioxygenase activity Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+. got7fsn_ti 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity|quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)|quinolin-2(1H)-one 5,6-dioxygenase activity|quinolin-2-ol 5,6-dioxygenase activity MetaCyc:1.14.12.16-RXN|UM-BBD_reactionID:r0052|EC:1.14.12.16|RHEA:10976 molecular_function owl:Class GO:0051048 biolink:NamedThing negative regulation of secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. got7fsn_ti down-regulation of secretion|down regulation of secretion|downregulation of secretion|inhibition of secretion biological_process owl:Class GO:0150053 biolink:NamedThing cerebellar climbing fiber to Purkinje cell synapse A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata. got7fsn_ti cerebellar climbing fibre to Purkinje cell synapse bc 2018-05-09T09:57:20Z cellular_component owl:Class GO:0098985 biolink:NamedThing asymmetric, glutamatergic, excitatory synapse A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials. got7fsn_ti cellular_component owl:Class GO:0008126 biolink:NamedThing acetylesterase activity Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. got7fsn_ti chloroesterase|acetic-ester acetylhydrolase activity|acetic ester hydrolase activity|p-nitrophenyl acetate esterase|C-esterase (in animal tissues)|citrus acetylesterase RHEA:12957|UM-BBD_reactionID:r0170|MetaCyc:ACETYLESTERASE-RXN|EC:3.1.1.6 molecular_function owl:Class GO:0034338 biolink:NamedThing short-chain carboxylesterase activity Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. got7fsn_ti monobutyrase activity|butyrate esterase activity|propionyl esterase activity|short-chain esterase activity|methylbutyrase activity|methylbutyrate esterase activity|butyryl esterase activity molecular_function owl:Class GO:0009238 biolink:NamedThing enterobactin metabolic process The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. got7fsn_ti enterochelin metabolic process|enterobactin metabolism|enterochelin metabolism biological_process owl:Class GO:0009237 biolink:NamedThing siderophore metabolic process The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. got7fsn_ti siderochrome metabolic process|siderophore metabolism|siderochrome metabolism biological_process owl:Class GO:0035087 biolink:NamedThing siRNA loading onto RISC involved in RNA interference The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference. got7fsn_ti RNA interference, siRNA loading onto RISC biological_process owl:Class GO:0070922 biolink:NamedThing small RNA loading onto RISC The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA. got7fsn_ti RISC assembly|gene silencing by RNA, small RNA loading onto RISC mah 2009-09-11T03:57:38Z biological_process owl:Class GO:0070919 biolink:NamedThing production of siRNA involved in gene silencing by small RNA Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of gene silencing by small RNA. got7fsn_ti production of siRNA involved in chromatin silencing by small RNA|chromatin silencing by small RNA, production of siRNA|chromatin silencing by small RNA, production of guide RNAs|production of guide RNAs involved in chromatin silencing by small RNA https://github.com/geneontology/go-ontology/issues/22058 mah 2009-09-11T03:39:18Z biological_process owl:Class GO:0070918 biolink:NamedThing production of small RNA involved in gene silencing by RNA The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. got7fsn_ti gene silencing by RNA, production of small RNA|gene silencing by RNA, production of guide RNA mah 2009-09-11T03:32:19Z biological_process owl:Class GO:0009340 biolink:NamedThing DNA topoisomerase IV complex A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA. got7fsn_ti cellular_component owl:Class GO:0009330 biolink:NamedThing DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity. got7fsn_ti cellular_component owl:Class GO:0072002 biolink:NamedThing Malpighian tubule development The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut. got7fsn_ti mah 2010-01-25T10:54:30Z biological_process owl:Class GO:0002143 biolink:NamedThing tRNA wobble position uridine thiolation The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. got7fsn_ti tRNA wobble uridine thiolation|wobble position s2U biosynthesis In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA. hjd 2009-05-06T05:05:40Z biological_process owl:Class GO:0002098 biolink:NamedThing tRNA wobble uridine modification The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified. got7fsn_ti biological_process owl:Class GO:0034745 biolink:NamedThing APC-IQGAP1-Rac1 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. got7fsn_ti Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class GO:0005892 biolink:NamedThing acetylcholine-gated channel complex A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. got7fsn_ti nicotinic acetylcholine-gated receptor-channel complex|nicotinic acetylcholine receptor cellular_component owl:Class GO:0034702 biolink:NamedThing ion channel complex A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. got7fsn_ti cellular_component owl:Class GO:1902492 biolink:NamedThing positive regulation of sperm capacitation Any process that activates or increases the frequency, rate or extent of sperm capacitation. got7fsn_ti positive regulation of sperm activation|upregulation of sperm capacitation|up-regulation of sperm activation|up regulation of sperm activation|activation of sperm capacitation|upregulation of sperm activation|activation of sperm activation|up regulation of sperm capacitation|up-regulation of sperm capacitation hjd 2013-11-12T21:17:21Z biological_process owl:Class GO:1902490 biolink:NamedThing regulation of sperm capacitation Any process that modulates the frequency, rate or extent of sperm capacitation. got7fsn_ti regulation of sperm activation hjd 2013-11-12T21:17:03Z biological_process owl:Class GO:0002191 biolink:NamedThing cap-dependent translational initiation The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation. got7fsn_ti hjd 2011-08-11T02:20:24Z biological_process owl:Class GO:0002183 biolink:NamedThing cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. got7fsn_ti hjd 2011-06-09T03:15:48Z biological_process owl:Class GO:0021787 biolink:NamedThing chemorepulsion of branchiomotor neuron axon in neural tube The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti negative chemotaxis of branchiomotor neuron axon in neural tube biological_process owl:Class GO:0021786 biolink:NamedThing branchiomotor neuron axon guidance in neural tube The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti biological_process owl:Class GO:0003330 biolink:NamedThing regulation of extracellular matrix constituent secretion Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. got7fsn_ti dph 2009-11-02T02:07:40Z biological_process owl:Class GO:1903530 biolink:NamedThing regulation of secretion by cell Any process that modulates the frequency, rate or extent of secretion by cell. got7fsn_ti regulation of cellular secretion pm 2014-10-08T13:24:59Z biological_process owl:Class GO:0048019 biolink:NamedThing receptor antagonist activity The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. got7fsn_ti receptor ligand activity molecular_function owl:Class GO:0030547 biolink:NamedThing signaling receptor inhibitor activity Binds to and modulates the activity of a signaling receptor. got7fsn_ti receptor inhibitor activity molecular_function owl:Class GO:0003828 biolink:NamedThing alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. got7fsn_ti ganglioside GD3 synthetase sialyltransferase activity|CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity|ganglioside GD3 synthase activity|CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity|alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity|GD3 synthase activity|CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity|alpha-2,8-sialyltransferase activity|SAT-2|cytidine monophosphoacetylneuraminate-ganglioside GM3 Reactome:R-HSA-1022133|Reactome:R-HSA-4084978|Reactome:R-HSA-422454|RHEA:19313|EC:2.4.99.8|MetaCyc:2.4.99.8-RXN molecular_function owl:Class GO:0004962 biolink:NamedThing endothelin receptor activity Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti endothelin-A receptor activity|endothelin-B receptor activity GO:0001599|GO:0001600 molecular_function owl:Class GO:0001139 biolink:NamedThing RNA polymerase II complex recruiting activity Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. got7fsn_ti core RNA polymerase II recruiting transcription factor activity|transcription factor activity, core RNA polymerase II recruiting krc 2011-01-20T05:55:01Z molecular_function owl:Class GO:0000993 biolink:NamedThing RNA polymerase II complex binding Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. got7fsn_ti RNAP II core binding|RNA polymerase II core binding krc 2010-08-11T03:57:27Z molecular_function owl:Class GO:0018421 biolink:NamedThing UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein. got7fsn_ti molecular_function owl:Class GO:0004933 biolink:NamedThing mating-type a-factor pheromone receptor activity Combining with the mating-type a-factor pheromone to initiate a change in cell activity. got7fsn_ti class D G-protein coupled receptor activity|class D GPCR activity|class D G-protein-coupled receptor activity|class D G protein coupled receptor activity molecular_function owl:Class GO:0004932 biolink:NamedThing mating-type factor pheromone receptor activity Combining with a mating-type factor pheromone to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class GO:0031152 biolink:NamedThing aggregation involved in sorocarp development The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. got7fsn_ti aggregate development involved in sorocarp development|aggregation during fruiting body development biological_process owl:Class GO:0051703 biolink:NamedThing biological process involved in intraspecies interaction between organisms Any process in which an organism has an effect on an organism of the same species. got7fsn_ti intraspecies interaction between organisms|intraspecies interaction with other organisms https://github.com/geneontology/go-ontology/issues/20191 biological_process owl:Class GO:0140035 biolink:NamedThing ubiquitination-like modification-dependent protein binding Binding to a protein upon modification by a ubiquitin-like protein of the target protein. got7fsn_ti This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. pg 2017-05-18T06:11:27Z molecular_function owl:Class GO:0140030 biolink:NamedThing modification-dependent protein binding Binding to a protein upon post-translation modification of the target protein. got7fsn_ti modified protein binding This term should only be used when the binding is shown to require a post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. pg 2017-05-17T11:50:41Z molecular_function owl:Class GO:0110092 biolink:NamedThing nucleus leading edge The area of a motile nucleus closest to the direction of movement. got7fsn_ti horsetail nucleus leading edge kmv 2018-02-14T22:39:58Z cellular_component owl:Class GO:2000848 biolink:NamedThing positive regulation of corticosteroid hormone secretion Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion. got7fsn_ti positive regulation of corticosteroid secretion bf 2011-07-26T08:43:45Z biological_process owl:Class GO:2000833 biolink:NamedThing positive regulation of steroid hormone secretion Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. got7fsn_ti bf 2011-07-26T08:38:51Z biological_process owl:Class GO:1990630 biolink:NamedThing IRE1-RACK1-PP2A complex A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A. got7fsn_ti ERN1-RACK1-PP2A complex|IRE1alpha-RACK1-PP2A complex bf 2015-02-05T15:37:58Z cellular_component owl:Class GO:0001776 biolink:NamedThing leukocyte homeostasis The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti immune cell homeostasis|leucocyte homeostasis Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. biological_process owl:Class GO:0048872 biolink:NamedThing homeostasis of number of cells Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. got7fsn_ti homeostasis of cell number|cell population homeostasis biological_process owl:Class GO:0048463 biolink:NamedThing carpel structural organization The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti carpel structural organisation GO:0048432 biological_process owl:Class GO:0048450 biolink:NamedThing floral organ structural organization The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti floral organ structural organisation GO:0048435 biological_process owl:Class GO:0060817 biolink:NamedThing inactivation of paternal X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex. got7fsn_ti dph 2009-08-11T10:50:20Z biological_process owl:Class GO:0009048 biolink:NamedThing dosage compensation by inactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex. got7fsn_ti X chromosome inactivation|chromosome inactivation|Barr body formation Wikipedia:X-inactivation biological_process owl:Class GO:0001193 biolink:NamedThing maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter. got7fsn_ti maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter krc 2011-09-02T02:31:00Z biological_process owl:Class GO:0001192 biolink:NamedThing maintenance of transcriptional fidelity during DNA-templated transcription elongation Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template. got7fsn_ti maintenance of transcriptional fidelity during DNA-dependent transcription elongation krc 2011-09-02T02:25:30Z biological_process owl:Class GO:0102196 biolink:NamedThing cortisol dehydrogenase activity Catalysis of the reaction: cortisol + NADP <=> cortisone + NADPH + H+. got7fsn_ti MetaCyc:RXN-12085 molecular_function owl:Class GO:0000931 biolink:NamedThing gamma-tubulin large complex A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe. got7fsn_ti gamma-tubulin large complex, equatorial microtubule organizing centre|gamma-tubulin ring complex, centrosomal|gamma-tubulin large complex, eMTOC|gamma-tubulin large complex, equatorial microtubule organizing center|gamma-tubulin ring complex|gamma-tubulin large complex, centrosomal|gamma-tubulin large complex, spindle pole body|gamma-tubulin large complex, mitotic spindle pole body|gamma-tubulin large complex, interphase microtubule organizing center|gamma-tubulin large complex, interphase microtubule organizing centre|gamma-tubulin large complex, iMTOC https://github.com/geneontology/go-ontology/issues/20967 GO:0000929|GO:0055031|GO:0000925|GO:0000926|GO:0055032|GO:0055033|GO:0000924|GO:0061494|GO:0008274 cellular_component owl:Class GO:0000930 biolink:NamedThing gamma-tubulin complex A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. got7fsn_ti cellular_component owl:Class GO:0007509 biolink:NamedThing mesoderm migration involved in gastrulation The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism. got7fsn_ti biological_process owl:Class GO:0090130 biolink:NamedThing tissue migration The process in which the population of cells that make up a tissue undergo directed movement. got7fsn_ti tb 2009-12-07T03:13:55Z biological_process owl:Class GO:0050141 biolink:NamedThing nitroethane oxidase activity Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2. got7fsn_ti nitroethane reductase activity|nitroethane:oxygen oxidoreductase activity EC:1.7.3.1|MetaCyc:NITROETHANE-OXIDASE-RXN molecular_function owl:Class GO:0052664 biolink:NamedThing nitroalkane oxidase activity Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2. got7fsn_ti nitroalkane:oxygen oxidoreductase activity|nitroalkane reductase activity|NAO activity 2010-10-11T10:50:59Z EC:1.7.3.1|MetaCyc:RXN-11045|KEGG_REACTION:R00799 molecular_function owl:Class GO:0014805 biolink:NamedThing smooth muscle adaptation Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. got7fsn_ti smooth muscle plasticity biological_process owl:Class GO:0043500 biolink:NamedThing muscle adaptation A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. got7fsn_ti muscle plasticity biological_process owl:Class GO:0032601 biolink:NamedThing connective tissue growth factor production The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Hcs24 production|Fisp12 production|CCN2 production|IGFBP8 production|hypertrophic chondrocyte-specific gene product 24 production|CTGF production biological_process owl:Class GO:0018865 biolink:NamedThing acrylonitrile metabolic process The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers. got7fsn_ti acrylonitrile metabolism UM-BBD_pathwayID:acr biological_process owl:Class GO:0034641 biolink:NamedThing cellular nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. got7fsn_ti cellular nitrogen compound metabolism biological_process owl:Class GO:0003405 biolink:NamedThing optic vesicle elongation The developmental growth that results in the lengthening of the optic vesicle in the posterior direction. got7fsn_ti dph 2009-12-21T01:59:50Z biological_process owl:Class GO:1900615 biolink:NamedThing emericellamide A metabolic process The chemical reactions and pathways involving emericellamide A. got7fsn_ti emericellamide A metabolism di 2012-05-15T07:59:59Z biological_process owl:Class GO:0036236 biolink:NamedThing acyl glucuronidation The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside). got7fsn_ti bf 2012-05-18T04:26:25Z biological_process owl:Class GO:0052695 biolink:NamedThing cellular glucuronidation The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. got7fsn_ti cellular glucuronide biosynthetic process|cellular glucuronide biosynthesis|cellular glucuronoside biosynthesis|cellular glucuronoside biosynthetic process 2011-07-27T05:28:18Z biological_process owl:Class GO:0004331 biolink:NamedThing fructose-2,6-bisphosphate 2-phosphatase activity Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. got7fsn_ti D-fructose-2,6-bisphosphate 2-phosphohydrolase activity|fructose-2,6-bisphosphatase activity|beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity GO:0004330 Reactome:R-HSA-70262|RHEA:17289|MetaCyc:3.1.3.46-RXN|Reactome:R-HSA-5628905|EC:3.1.3.46 molecular_function owl:Class GO:0034364 biolink:NamedThing high-density lipoprotein particle A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. got7fsn_ti HDL particle|HDL2|HDL complex|HDL3|high-density lipoprotein class complex cellular_component owl:Class GO:0070184 biolink:NamedThing mitochondrial tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class GO:0070127 biolink:NamedThing tRNA aminoacylation for mitochondrial protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion. got7fsn_ti biological_process owl:Class GO:0061696 biolink:NamedThing pituitary gonadotropin complex A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function. got7fsn_ti dph 2015-05-06T13:11:18Z cellular_component owl:Class GO:0099106 biolink:NamedThing ion channel regulator activity Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. got7fsn_ti molecular_function owl:Class GO:0090504 biolink:NamedThing epiboly The expansion of one cell sheet over other cells or yolk. got7fsn_ti tb 2012-10-22T12:29:52Z biological_process owl:Class GO:0002011 biolink:NamedThing morphogenesis of an epithelial sheet The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. got7fsn_ti biological_process owl:Class GO:0044345 biolink:NamedThing stromal-epithelial cell signaling involved in prostate gland development The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development. got7fsn_ti stromal-epithelial cell signalling involved in prostate gland development jl 2010-08-25T02:06:34Z biological_process owl:Class GO:0007267 biolink:NamedThing cell-cell signaling Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. got7fsn_ti cell-cell signalling biological_process owl:Class GO:0061655 biolink:NamedThing Pup conjugating enzyme activity Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y -> Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2 dph 2014-11-06T13:30:46Z molecular_function owl:Class GO:0072496 biolink:NamedThing Pup transferase activity Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y --> Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages. got7fsn_ti Pup conjugating enzyme activity mah 2010-12-15T11:58:13Z molecular_function owl:Class GO:0090278 biolink:NamedThing negative regulation of peptide hormone secretion Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. got7fsn_ti tb 2010-02-05T02:56:39Z biological_process owl:Class GO:0052312 biolink:NamedThing modulation of transcription in other organism involved in symbiotic interaction Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modulation of transcription in other organism during symbiotic interaction biological_process owl:Class GO:0090462 biolink:NamedThing ornithine homeostasis Any process involved in the maintenance of an internal steady state of ornithine within an organism or cell. got7fsn_ti tb 2012-09-24T14:22:02Z biological_process owl:Class GO:0080144 biolink:NamedThing amino acid homeostasis Any process involved in the maintenance of an internal steady state of amino acid within an organism or cell. got7fsn_ti dhl 2010-01-27T04:47:27Z biological_process owl:Class GO:0018296 biolink:NamedThing protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine. got7fsn_ti RESID:AA0145 biological_process owl:Class GO:0018293 biolink:NamedThing protein-FAD linkage The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD). got7fsn_ti biological_process owl:Class GO:0102979 biolink:NamedThing homofuraneol oxidoreductase activity Catalysis of the reaction: homofuraneol + NADP <=> (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+. got7fsn_ti RHEA:53944|MetaCyc:RXN-9564 molecular_function owl:Class GO:0140226 biolink:NamedThing RNA topoisomerase activity Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA. got7fsn_ti pg 2018-05-29T11:06:37Z molecular_function owl:Class GO:0016853 biolink:NamedThing isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. got7fsn_ti other isomerase activity Reactome:R-HSA-6787623|EC:5.-.-.- molecular_function owl:Class GO:0030540 biolink:NamedThing female genitalia development The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. got7fsn_ti female genital development biological_process owl:Class GO:0048806 biolink:NamedThing genitalia development The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. got7fsn_ti genital development biological_process owl:Class GO:0007497 biolink:NamedThing posterior midgut development The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class GO:0021984 biolink:NamedThing adenohypophysis development The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. got7fsn_ti anterior pituitary development|adenophysis development|anterior pituitary gland development biological_process owl:Class GO:0046856 biolink:NamedThing phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol. got7fsn_ti phosphatidylinositol phosphate dephosphorylation|PtdInsP catabolism|PtdInsP dephosphorylation|PIP catabolism|phosphoinositide dephosphorylation|phosphatidylinositol phosphate catabolic process GO:0046840 biological_process owl:Class GO:0046839 biolink:NamedThing phospholipid dephosphorylation The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. got7fsn_ti biological_process owl:Class GO:0038083 biolink:NamedThing peptidyl-tyrosine autophosphorylation The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. got7fsn_ti receptor tyrosine kinase autophosphorylation|RTK autophosphorylation|tyrosine autophosphorylation bf 2012-02-01T02:14:18Z biological_process owl:Class GO:0046777 biolink:NamedThing protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). got7fsn_ti protein amino acid autophosphorylation Wikipedia:Autophosphorylation biological_process owl:Class GO:0001587 biolink:NamedThing Gq/11-coupled serotonin receptor activity Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. got7fsn_ti serotonin receptor activity, coupled via Gq/11|5-HT2 receptor activity molecular_function owl:Class GO:0004993 biolink:NamedThing G protein-coupled serotonin receptor activity Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. got7fsn_ti G protein coupled serotonin receptor activity|5-HT receptor|G-protein coupled serotonin receptor activity|5-hydroxytryptamine receptor https://github.com/geneontology/go-ontology/issues/12942 GO:0001585|GO:0016609 Wikipedia:5-HT_receptor molecular_function owl:Class GO:0048649 biolink:NamedThing caste determination, influence by genetic factors The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. got7fsn_ti biological_process owl:Class GO:0048652 biolink:NamedThing polyphenic determination, influence by genetic factors The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues. got7fsn_ti biological_process owl:Class GO:0031783 biolink:NamedThing type 5 melanocortin receptor binding Binding to a type 5 melanocortin receptor. got7fsn_ti type 5 melanocortin receptor ligand molecular_function owl:Class GO:0031779 biolink:NamedThing melanocortin receptor binding Binding to a melanocortin receptor. got7fsn_ti melanocortin receptor ligand molecular_function owl:Class GO:0051213 biolink:NamedThing dioxygenase activity Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. got7fsn_ti Reactome:R-HSA-112121|Reactome:R-HSA-112125|Reactome:R-HSA-112124|Reactome:R-HSA-112120 molecular_function owl:Class GO:0047407 biolink:NamedThing ADP-ribosyl-[dinitrogen reductase] hydrolase activity Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]. got7fsn_ti ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity|ADP-ribosyl glycohydrolase activity|azoferredoxin-activating enzymes|ADP-ribosyl-dinitrogen reductase hydrolase activity|dinitrogenase reductase activating glycohydrolase activity|azoferredoxin glycosidase activity|dinitrogenase reductase-activating glycohydrolase activity MetaCyc:3.2.2.24-RXN|EC:3.2.2.24|RHEA:14493 molecular_function owl:Class GO:0021964 biolink:NamedThing rubrospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord. got7fsn_ti biological_process owl:Class GO:0021952 biolink:NamedThing central nervous system projection neuron axonogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. got7fsn_ti central nervous system axon tract development biological_process owl:Class GO:0019165 biolink:NamedThing thiamine kinase activity Catalysis of the reaction: ATP + thiamine = ADP + 2 H(+) + thiamine phosphate. got7fsn_ti ATP:thiamine phosphotransferase activity|thiamin phosphokinase activity|thiamin kinase (phosphorylating)|ATP:thiamin phosphotransferase activity|thiamin kinase activity RHEA:12012|KEGG_REACTION:R02134|EC:2.7.1.89|MetaCyc:THIKIN-RXN molecular_function owl:Class GO:1904318 biolink:NamedThing regulation of smooth muscle contraction involved in micturition Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition. got7fsn_ti regulation of smooth muscle contraction involved in urination|regulation of urinary bladder smooth muscle contraction involved in micturition sl 2015-06-10T18:46:11Z biological_process owl:Class GO:0044062 biolink:NamedThing regulation of excretion Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. got7fsn_ti biological_process owl:Class GO:0046155 biolink:NamedThing rhodopsin catabolic process The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. got7fsn_ti rhodopsin catabolism|rhodopsin degradation|rhodopsin breakdown biological_process owl:Class GO:0046154 biolink:NamedThing rhodopsin metabolic process The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. got7fsn_ti rhodopsin metabolism biological_process owl:Class GO:0102247 biolink:NamedThing malonyl-malonyl acyl carrier protein-condensing enzyme activity Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] <=> 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-12361 molecular_function owl:Class GO:0003376 biolink:NamedThing sphingosine-1-phosphate receptor signaling pathway A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti S1P signaling pathway|sphingolipid signaling pathway|S1P receptor signaling pathway|sphingolipid signalling pathway|S1P-activated GPCR signaling pathway|S1P-stimulated signal transduction pathway|S1P-activated G-protein coupled receptor signaling pathway https://github.com/geneontology/go-ontology/issues/15822 dph 2009-12-09T06:30:12Z GO:0001789 biological_process owl:Class GO:0007186 biolink:NamedThing G protein-coupled receptor signaling pathway A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane. got7fsn_ti GPCR signalling pathway|dimeric G-protein coupled receptor signalling pathway|G-protein-coupled receptor protein signalling pathway|G-protein coupled receptor signalling pathway|G-protein coupled receptor protein signal transduction|G protein coupled receptor protein signaling pathway|G-protein coupled receptor signaling pathway via GPCR dimer|GPCR signaling pathway|G protein coupled receptor protein signalling pathway|G-protein coupled receptor protein signaling pathway|dimeric G-protein coupled receptor signaling pathway GO:0038042 biological_process owl:Class GO:0070705 biolink:NamedThing RNA nucleotide insertion The modification of an RNA molecule by insertion of one or more nucleotides. got7fsn_ti mah 2009-06-08T04:48:35Z biological_process owl:Class GO:0009451 biolink:NamedThing RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. got7fsn_ti RNA editing The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. GO:0016547 Wikipedia:RNA_editing biological_process owl:Class GO:0001698 biolink:NamedThing gastrin-induced gastric acid secretion The regulated release of gastric acid induced by the interaction of gastrin with its receptor. got7fsn_ti biological_process owl:Class GO:0001696 biolink:NamedThing gastric acid secretion The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. got7fsn_ti hydrochloric acid secretion biological_process owl:Class GO:0042749 biolink:NamedThing regulation of circadian sleep/wake cycle Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. got7fsn_ti biological_process owl:Class GO:0050795 biolink:NamedThing regulation of behavior Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. got7fsn_ti regulation of behaviour biological_process owl:Class GO:0071013 biolink:NamedThing catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. got7fsn_ti mammalian spliceosomal complex C1|yeast spliceosomal complex A2-2|mammalian spliceosomal complex C mah 2009-07-30T12:00:35Z cellular_component owl:Class GO:0004459 biolink:NamedThing L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. got7fsn_ti L-lactic acid dehydrogenase activity|L-lactic dehydrogenase activity Reactome:R-HSA-71849|Reactome:R-HSA-70510|EC:1.1.1.27|RHEA:23444|MetaCyc:L-LACTATE-DEHYDROGENASE-RXN|Reactome:R-HSA-6807826 molecular_function owl:Class GO:0040040 biolink:NamedThing thermosensory behavior Behavior that is dependent upon the sensation of temperature. got7fsn_ti behavioral response to temperature stimulus|behavioural response to temperature stimulus|thermosensory behaviour biological_process owl:Class GO:0009266 biolink:NamedThing response to temperature stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. got7fsn_ti response to thermal stimulus biological_process owl:Class GO:0106139 biolink:NamedThing symbiont cell surface The cell surface of a secondary, endosymbiont organism with which the first organism is interacting. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti endosymbiont cell surface hjd 2018-08-15T18:56:57Z cellular_component owl:Class GO:0044217 biolink:NamedThing other organism part Any constituent part of a secondary organism with which the first organism is interacting. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. jl 2009-11-12T01:18:21Z cellular_component owl:Class GO:0018298 biolink:NamedThing protein-chromophore linkage The covalent or noncovalent attachment of a chromophore to a protein. got7fsn_ti biological_process owl:Class GO:0090585 biolink:NamedThing protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class GO:0016971 biolink:NamedThing flavin-linked sulfhydryl oxidase activity Catalysis of the formation of disulfide bridges in proteins using FAD as the electron acceptor. got7fsn_ti molecular_function owl:Class GO:0016972 biolink:NamedThing thiol oxidase activity Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O2. got7fsn_ti sulfhydryl oxidase activity|thiol:oxygen oxidoreductase activity RHEA:17357|MetaCyc:THIOL-OXIDASE-RXN|UM-BBD_reactionID:r1293|EC:1.8.3.2 molecular_function owl:Class GO:0052889 biolink:NamedThing 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene The series of reactions in which 9,9'-di-cis-zeta-carotene is desaturated to 7,9,9'-tri-cis-neurosporene, and then 7,9,7',9'-tetra-cis-lycopene. The overall reaction for this process is: 9,9'-di-cis-zeta-carotene + 2 quinone = 2 quinol + 7,9,7',9'-tetra-cis-lycopene. got7fsn_ti 9,9'-di-cis-zeta-carotene catabolism to 7,9,7',9'-tetra-cis-lycopene|7,9,7',9'-tetra-cis-lycopene biosynthesis from 9,9'-di-cis-zeta-carotene MetaCyc:RXN-12242|KEGG_REACTION:R07511 biological_process owl:Class GO:0016119 biolink:NamedThing carotene metabolic process The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids. got7fsn_ti carotene metabolism biological_process owl:Class GO:0031637 biolink:NamedThing regulation of neuronal synaptic plasticity in response to neurotrophin The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. got7fsn_ti neurotrophin-induced neuronal synaptic plasticity biological_process owl:Class GO:0048168 biolink:NamedThing regulation of neuronal synaptic plasticity A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. got7fsn_ti Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class GO:0050603 biolink:NamedThing thiophene-2-carbonyl-CoA monooxygenase activity Catalysis of the reaction: AH(2) + O(2) + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(2)O + H(+). got7fsn_ti thiophene-2-carboxyl-CoA dehydrogenase activity|thiophene-2-carboxyl-CoA monooxygenase activity|thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity|thiophene-2-carboxyl-CoA hydroxylase activity RHEA:18929|MetaCyc:1.14.99.35-RXN|UM-BBD_reactionID:r1235|EC:1.14.99.35|KEGG_REACTION:R05742 molecular_function owl:Class GO:0052801 biolink:NamedThing bicyclic nitroimidazole metabolic process The chemical reactions and pathways involving bicyclic nitroimidazoles, imidazole derivatives with two rings and a nitro group attached to one ring. got7fsn_ti bicyclic nitroimidazole metabolism biological_process owl:Class GO:0052802 biolink:NamedThing nitroimidazole metabolic process The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring. got7fsn_ti nitroimidazole metabolism biological_process owl:Class GO:0097192 biolink:NamedThing extrinsic apoptotic signaling pathway in absence of ligand A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. got7fsn_ti extrinsic apoptosis in absence of ligand|dependence receptor signaling pathway|extrinsic apoptotic signalling pathway in absence of ligand For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154). pr 2011-11-23T09:37:09Z biological_process owl:Class GO:0039580 biolink:NamedThing suppression by virus of host PKR signaling Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response. got7fsn_ti suppression by virus of host EIF2AK2 activity|suppression by virus of host PKR activity https://github.com/geneontology/go-ontology/issues/21971 bf biological_process owl:Class GO:0019057 biolink:NamedThing modulation by virus of host translation Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA. got7fsn_ti viral host shutoff protein|host cell shutoff|regulation of host mRNA translation by virus|modulation of host translation by virus|regulation of host translation by virus|viral perturbation of host cell mRNA translation|regulation of translation in host by virus|host cell protein synthesis shutoff|modification by virus of host cell mRNA translation biological_process owl:Class GO:0045841 biolink:NamedThing negative regulation of mitotic metaphase/anaphase transition Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. got7fsn_ti inhibition of mitotic metaphase/anaphase transition|downregulation of mitotic metaphase/anaphase transition|down-regulation of mitotic metaphase/anaphase transition|down regulation of mitotic metaphase/anaphase transition biological_process owl:Class GO:0045839 biolink:NamedThing negative regulation of mitotic nuclear division Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. got7fsn_ti inhibition of mitosis|negative regulation of mitosis|down regulation of mitosis|down-regulation of mitosis|downregulation of mitosis biological_process owl:Class GO:0035011 biolink:NamedThing melanotic encapsulation of foreign target Formation of a multilayered, melanized sheath of cells around a foreign invader. got7fsn_ti biological_process owl:Class GO:0035010 biolink:NamedThing encapsulation of foreign target Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization. got7fsn_ti biological_process owl:Class GO:0061324 biolink:NamedThing canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells. got7fsn_ti canonical Wnt receptor signalling pathway involved in positive regulation of cardiac outflow tract cell proliferation|canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation|canonical Wnt-activated signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation dph 2010-09-28T09:19:37Z biological_process owl:Class GO:0061316 biolink:NamedThing canonical Wnt signaling pathway involved in heart development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. got7fsn_ti canonical Wnt receptor signaling pathway involved in heart development|canonical Wnt receptor signalling pathway involved in heart development|canonical Wnt-activated signaling pathway involved in heart development dph 2010-09-24T09:25:03Z biological_process owl:Class GO:0052131 biolink:NamedThing positive aerotaxis The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen. got7fsn_ti biological_process owl:Class GO:0009454 biolink:NamedThing aerotaxis The directed movement of a motile cell or organism in response to environmental oxygen. got7fsn_ti taxis in response to atmospheric oxygen biological_process owl:Class GO:0048307 biolink:NamedThing ferredoxin-nitrite reductase activity Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+. got7fsn_ti ammonia:ferredoxin oxidoreductase activity MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN|EC:1.7.7.1|RHEA:18041 molecular_function owl:Class GO:0098809 biolink:NamedThing nitrite reductase activity Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor. got7fsn_ti molecular_function owl:Class GO:0002694 biolink:NamedThing regulation of leukocyte activation Any process that modulates the frequency, rate, or extent of leukocyte activation. got7fsn_ti regulation of leucocyte activation|regulation of immune cell activation biological_process owl:Class GO:0035184 biolink:NamedThing histone threonine kinase activity Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. got7fsn_ti histone-threonine kinase activity molecular_function owl:Class GO:0035173 biolink:NamedThing histone kinase activity Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. got7fsn_ti molecular_function owl:Class GO:0120242 biolink:NamedThing 2-iminobutanoate deaminase activity Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+). got7fsn_ti 2-iminobutanoate/2-iminopropanoate deaminase https://github.com/geneontology/go-ontology/issues/19832 krc 2020-07-29T18:07:00Z KEGG_REACTION:R11098|MetaCyc:RXN-15123|RHEA:39975 molecular_function owl:Class GO:0120241 biolink:NamedThing 2-iminobutanoate/2-iminopropanoate deaminase Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17. got7fsn_ti imine intermediate deaminase activity|2-iminopropanoate deaminase|2-iminobutanoate deaminase|enamine/imine deaminase https://github.com/geneontology/go-ontology/issues/19832 This enzyme, which has been found in all species and tissues examined, catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates (from EC:3.5.99.10). krc 2020-07-29T17:28:19Z EC:3.5.99.10 molecular_function owl:Class GO:0016159 biolink:NamedThing muconolactone delta-isomerase activity Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate. got7fsn_ti muconolactone isomerase activity|5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity|muconolactone D-isomerase activity RHEA:12348|MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN|EC:5.3.3.4 molecular_function owl:Class GO:0016863 biolink:NamedThing intramolecular oxidoreductase activity, transposing C=C bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. got7fsn_ti intramolecular isomerase activity, transposing C=C bonds EC:5.3.3.- molecular_function owl:Class GO:0017024 biolink:NamedThing myosin I binding Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments. got7fsn_ti molecular_function owl:Class GO:0017022 biolink:NamedThing myosin binding Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. got7fsn_ti myosin phosphatase myosin binding molecular_function owl:Class GO:0047200 biolink:NamedThing tetrahydrodipicolinate N-acetyltransferase activity Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H(2)O = L-2-acetamido-6-oxopimelate + CoA. got7fsn_ti tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity|acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity|tetrahydrodipicolinate acetylase activity|acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity|acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity RHEA:13085|MetaCyc:2.3.1.89-RXN|KEGG_REACTION:R04364|EC:2.3.1.89 molecular_function owl:Class GO:0031509 biolink:NamedThing subtelomeric heterochromatin assembly The assembly of chromatin into heterochromatin at the subtelomeric region, resulting in a chromatin conformation refractory to transcription. got7fsn_ti Telomere Position Effect|telomeric heterochromatin assembly|chromatin silencing at subtelomere|heterochromatic silencing at subtelomere|regulation of chromatin silencing at telomere|establishment of chromatin silencing at telomere|telomere chromatin silencing|telomeric heterochromatin formation|chromatin silencing at telomere|telomeric silencing|subtelomere chromatin silencing|subtelomeric silencing|regulation of subtelomeric heterochromatin assembly|heterochromatic silencing at telomere https://github.com/geneontology/go-ontology/issues/22027|https://github.com/geneontology/go-ontology/issues/19308|https://github.com/geneontology/go-ontology/issues/19188 GO:0099114|GO:0006348|GO:0035390 biological_process owl:Class GO:0042653 biolink:NamedThing mitochondrial respiratory chain complex I, membrane segment The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. got7fsn_ti NADH-Q oxidoreductase complex, membrane segment cellular_component owl:Class GO:0098798 biolink:NamedThing mitochondrial protein-containing complex A protein complex that is part of a mitochondrion. got7fsn_ti mitochondrial protein complex Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular_component owl:Class GO:0050385 biolink:NamedThing ureidoglycolate lyase activity Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea. got7fsn_ti ureidoglycolate hydrolase activity|ureidoglycolatase activity|(S)-ureidoglycolate urea-lyase activity|(S)-ureidoglycolate urea-lyase (glyoxylate-forming)|ureidoglycolase activity Take care to annotate to the reaction, not simply by enzyme name. Note that the name "ureidoglycolate hydrolase" (listed as a synonym here) has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19 ; GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3 ; GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. MetaCyc:UREIDOGLYCOLATE-LYASE-RXN|KEGG_REACTION:R00776|EC:4.3.2.3|RHEA:11304 molecular_function owl:Class GO:0016842 biolink:NamedThing amidine-lyase activity Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. got7fsn_ti EC:4.3.2.- molecular_function owl:Class GO:0009690 biolink:NamedThing cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. got7fsn_ti cytokinin metabolism biological_process owl:Class GO:0006725 biolink:NamedThing cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. got7fsn_ti aromatic compound metabolism|aromatic hydrocarbon metabolic process|aromatic hydrocarbon metabolism biological_process owl:Class GO:0080082 biolink:NamedThing esculin beta-glucosidase activity Catalysis of the hydrolysis of glucosidic link in esculin. got7fsn_ti dhl 2009-04-14T04:09:42Z molecular_function owl:Class GO:0008422 biolink:NamedThing beta-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. got7fsn_ti primeverosidase activity|arbutinase activity|salicilinase activity|gentobiase activity|elaterase activity|beta-glucoside glucohydrolase activity|limarase activity|gentiobiase activity|aryl-beta-glucosidase activity|beta-D-glucosidase activity|cytokine beta-glucosidase activity|beta-D-glucoside glucohydrolase activity|emulsin|beta-1,6-glucosidase activity|cellobiase activity|amygdalase activity|amygdalinase|p-nitrophenyl beta-glucosidase activity GO:0016983 MetaCyc:3.2.1.21-RXN|EC:3.2.1.21 molecular_function owl:Class GO:0004527 biolink:NamedThing exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. got7fsn_ti exonuclease IX activity GO:0008857 molecular_function owl:Class GO:0004518 biolink:NamedThing nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids. got7fsn_ti Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. molecular_function owl:Class GO:0018553 biolink:NamedThing 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate. got7fsn_ti UM-BBD_enzymeID:e0309 molecular_function owl:Class GO:0071454 biolink:NamedThing cellular response to anoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. got7fsn_ti cellular response to anoxic stress|cellular response to anaerobic conditions Note that this term should not be confused with 'cellular response to hypoxia ; GO:0071456'. mah 2009-12-16T04:44:20Z biological_process owl:Class GO:0080114 biolink:NamedThing positive regulation of glycine hydroxymethyltransferase activity Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. got7fsn_ti dhl 2009-04-27T03:27:15Z biological_process owl:Class GO:0006895 biolink:NamedThing Golgi to endosome transport The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. got7fsn_ti TGN to endosome transport|Golgi to endosome vesicle-mediated transport|trans-Golgi to endosome transport GO:0048218 biological_process owl:Class GO:0009604 biolink:NamedThing detection of symbiotic bacterium The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal. got7fsn_ti perception of symbiotic bacteria|detection of symbiotic bacteria|perception of symbiotic bacterium biological_process owl:Class GO:0009602 biolink:NamedThing detection of symbiont The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti perception of symbiont|recognition of symbiont https://github.com/geneontology/go-ontology/issues/17977 GO:0051855 biological_process owl:Class GO:0061626 biolink:NamedThing pharyngeal arch artery morphogenesis The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. got7fsn_ti aortic arch artery morphogenesis dph 2014-05-09T15:34:06Z biological_process owl:Class GO:0048844 biolink:NamedThing artery morphogenesis The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. got7fsn_ti arteriogenesis|arterial morphogenesis biological_process owl:Class GO:0018756 biolink:NamedThing ammeline aminohydrolase activity Catalysis of the reaction: ammeline + H2O = ammelide + NH3. got7fsn_ti MetaCyc:RXN-8016|RHEA:26201 molecular_function owl:Class GO:0016813 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. got7fsn_ti EC:3.5.3.- molecular_function owl:Class GO:0035224 biolink:NamedThing genital disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium). got7fsn_ti biological_process owl:Class GO:0007448 biolink:NamedThing anterior/posterior pattern specification, imaginal disc The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form. got7fsn_ti biological_process owl:Class GO:0047103 biolink:NamedThing 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate. got7fsn_ti 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity|3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity|THAL-NAD oxidoreductase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity|cholestanetriol-26-al 26-dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity|trihydroxydeoxycoprostanal dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity MetaCyc:1.2.1.40-RXN|RHEA:24584 molecular_function owl:Class GO:0002167 biolink:NamedThing VRK3/VHR/ERK complex A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway. got7fsn_ti hjd 2010-03-04T01:15:05Z cellular_component owl:Class GO:0021626 biolink:NamedThing central nervous system maturation A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. got7fsn_ti biological_process owl:Class GO:0060830 biolink:NamedThing ciliary receptor clustering involved in smoothened signaling pathway Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway. got7fsn_ti ciliary receptor clustering involved in hedgehog signaling pathway|ciliary receptor clustering involved in smoothened signalling pathway|ciliary receptor clustering involved in hh signaling pathway dph 2009-08-11T02:06:33Z biological_process owl:Class GO:0043113 biolink:NamedThing receptor clustering The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. got7fsn_ti biological_process owl:Class GO:0005581 biolink:NamedThing collagen trimer A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. got7fsn_ti Wikipedia:Collagen cellular_component owl:Class GO:0002702 biolink:NamedThing positive regulation of production of molecular mediator of immune response Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. got7fsn_ti upregulation of production of molecular mediator of immune response|up regulation of production of molecular mediator of immune response|stimulation of production of molecular mediator of immune response|up-regulation of production of molecular mediator of immune response|activation of production of molecular mediator of immune response biological_process owl:Class GO:0002700 biolink:NamedThing regulation of production of molecular mediator of immune response Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. got7fsn_ti biological_process owl:Class GO:0060242 biolink:NamedThing contact inhibition The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation. got7fsn_ti detection of cell density by contact stimulus involved in contact inhibition|detection of cell density by contact stimulus GO:0060248|GO:0060246 Wikipedia:Contact_inhibition biological_process owl:Class GO:0060245 biolink:NamedThing detection of cell density The series of events in which information about the density of cells in a population is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class GO:0046940 biolink:NamedThing nucleoside monophosphate phosphorylation The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside. got7fsn_ti biological_process owl:Class GO:0009123 biolink:NamedThing nucleoside monophosphate metabolic process The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. got7fsn_ti nucleoside monophosphate metabolism biological_process owl:Class GO:0000411 biolink:NamedThing positive regulation of transcription by galactose Any process involving galactose that activates or increases the rate of transcription. got7fsn_ti up regulation of transcription by galactose|stimulation of transcription by galactose|activation of transcription by galactose|up-regulation of transcription by galactose|upregulation of transcription by galactose biological_process owl:Class GO:0010327 biolink:NamedThing acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate. got7fsn_ti hexenol acetyltransferase molecular_function owl:Class GO:0005550 biolink:NamedThing pheromone binding Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. got7fsn_ti molecular_function owl:Class GO:0005549 biolink:NamedThing odorant binding Binding to an odorant, any substance capable of stimulating the sense of smell. got7fsn_ti molecular_function owl:Class GO:0009455 biolink:NamedThing redox taxis The directed movement of a motile cell or organism in response to redox potential. got7fsn_ti redoxtaxis|taxis in response to redox potential|taxis in response to redox stimulus biological_process owl:Class GO:0051775 biolink:NamedThing response to redox state Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. got7fsn_ti redox signal response GO:0006980 biological_process owl:Class GO:0044176 biolink:NamedThing host cell filopodium Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. got7fsn_ti host filopodium jl 2009-09-04T03:06:59Z cellular_component owl:Class GO:0044157 biolink:NamedThing host cell projection A prolongation or process extending from a host cell, e.g. a flagellum or axon. got7fsn_ti jl 2009-08-11T04:07:24Z cellular_component owl:Class GO:0016714 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. got7fsn_ti EC:1.14.16.- molecular_function owl:Class GO:0034996 biolink:NamedThing RasGAP-Fyn-Lyn-Yes complex A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation. got7fsn_ti p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class GO:0039503 biolink:NamedThing suppression by virus of host innate immune response Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense. got7fsn_ti negative regulation by virus of host innate immune response|inhibition of host innate immune response by virus|negative regulation by virus of host innate immunity|suppression by virus of host innate immunity bf 2011-05-11T04:31:17Z biological_process owl:Class GO:0102050 biolink:NamedThing indole-3-acetyl-tyrosine synthetase activity Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) <=> H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10432 molecular_function owl:Class GO:0016879 biolink:NamedThing ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti other carbon-nitrogen ligase activity EC:6.3.-.- molecular_function owl:Class GO:0050029 biolink:NamedThing L-lysine oxidase activity Catalysis of the reaction: L-lysine + H(2)O + O(2) = 6-amino-2-oxohexanoate + H(2)O(2) + NH(4)(+). got7fsn_ti L-lysyl-alpha-oxidase activity|L-lysine:oxygen 2-oxidoreductase (deaminating)|L-lysine alpha-oxidase activity EC:1.4.3.14|MetaCyc:PWY-5311|KEGG_REACTION:R00447|MetaCyc:L-LYSINE-OXIDASE-RXN|RHEA:14437 molecular_function owl:Class GO:0001716 biolink:NamedThing L-amino-acid oxidase activity Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. got7fsn_ti L-amino-acid:oxygen oxidoreductase (deaminating)|ophio-amino-acid oxidase activity RHEA:13781|MetaCyc:L-AMINO-ACID-OXIDASE-RXN|Reactome:R-HSA-2160492|EC:1.4.3.2 molecular_function owl:Class GO:0047860 biolink:NamedThing diiodophenylpyruvate reductase activity Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH. got7fsn_ti 3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity|KAR|aromatic alpha-keto acid|2-oxo acid reductase activity KEGG_REACTION:R03431|RHEA:20293|MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN|EC:1.1.1.96 molecular_function owl:Class GO:0061154 biolink:NamedThing endothelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. got7fsn_ti dph 2010-06-15T09:05:00Z biological_process owl:Class GO:0003159 biolink:NamedThing morphogenesis of an endothelium The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. got7fsn_ti dph 2009-10-01T01:34:06Z biological_process owl:Class GO:0044855 biolink:NamedThing plasma membrane raft distribution The process that establishes the spatial arrangement of membrane rafts within a plasma membrane. got7fsn_ti jl 2014-07-23T16:00:41Z biological_process owl:Class GO:0044856 biolink:NamedThing plasma membrane raft localization Any process in which plasma membrane rafts are transported to, or maintained in, a specific location. got7fsn_ti jl 2014-07-23T16:12:22Z biological_process owl:Class GO:0034376 biolink:NamedThing conversion of discoidal high-density lipoprotein particle to spherical high-density lipoprotein particle The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle. got7fsn_ti discoidal high-density lipoprotein remodeling|discoidal HDL remodeling|conversion of discoidal HDL to spherical HDL biological_process owl:Class GO:0034375 biolink:NamedThing high-density lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. got7fsn_ti HDL remodeling biological_process owl:Class GO:0010842 biolink:NamedThing retina layer formation The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. got7fsn_ti retinal layer formation|retinal lamination biological_process owl:Class GO:0052795 biolink:NamedThing exo-alpha-(2->6)-sialidase activity Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates. got7fsn_ti exo-alpha-2,6-sialidase activity|exo-alpha-(2,6)-sialidase activity EC:3.2.1.18 molecular_function owl:Class GO:0004308 biolink:NamedThing exo-alpha-sialidase activity Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. got7fsn_ti alpha-neuraminidase activity|acetylneuraminyl hydrolase activity|acetylneuraminidase activity|N-acylneuraminate glycohydrolase activity|neuraminidase activity|sialidase activity Reactome:R-HSA-4085029|Reactome:R-HSA-1605724|Reactome:R-HSA-4084994|Reactome:R-HSA-168870|EC:3.2.1.18|Reactome:R-HSA-4341669|Reactome:R-HSA-1605768|Reactome:R-HSA-1605723|Reactome:R-HSA-9638120|MetaCyc:3.2.1.18-RXN|Reactome:R-HSA-4084999 molecular_function owl:Class GO:1990665 biolink:NamedThing AnxA2-p11 complex A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10). got7fsn_ti (p11)2.(AnxA2)2 complex|AnxA2.p11 complex|AnxA2:S100A10 heterotetramer|Annexin A2 tetramer|Annexin A2-p11 complex|(A2.p11)2 complex bf 2015-03-02T10:07:42Z cellular_component owl:Class GO:0009972 biolink:NamedThing cytidine deamination The removal of amino group in the presence of water. got7fsn_ti biological_process owl:Class GO:0006216 biolink:NamedThing cytidine catabolic process The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside. got7fsn_ti cytidine degradation|cytidine catabolism|cytidine breakdown biological_process owl:Class GO:0045055 biolink:NamedThing regulated exocytosis A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. got7fsn_ti regulated secretory pathway biological_process owl:Class GO:0006887 biolink:NamedThing exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. got7fsn_ti nonselective vesicle exocytosis|vesicle exocytosis GO:0016194|GO:0016195 Wikipedia:Exocytosis biological_process owl:Class GO:0051507 biolink:NamedThing beta-sitosterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol. got7fsn_ti RHEA:61832|MetaCyc:RXN-12128 molecular_function owl:Class GO:0016906 biolink:NamedThing sterol 3-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol. got7fsn_ti sterol:UDPG glucosyltransferase activity|sterol 3beta-glucosyltransferase activity|UDPG:sterol glucosyltransferase activity|sterol-beta-D-glucosyltransferase activity|UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity|UDP-glucose:sterol glucosyltransferase activity|UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity|UDP-glucose-sterol beta-glucosyltransferase activity|UDPG-SGTase activity|sterol glucosyltransferase activity|uridine diphosphoglucose-poriferasterol glucosyltransferase activity|UDP-glucose-sterol glucosyltransferase activity|uridine diphosphoglucose-sterol glucosyltransferase activity EC:2.4.1.173|MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN|RHEA:22724 molecular_function owl:Class GO:0000971 biolink:NamedThing tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans. got7fsn_ti krc 2009-04-28T10:36:17Z biological_process owl:Class GO:0000968 biolink:NamedThing tRNA exon ligation An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed. got7fsn_ti krc 2009-04-28T10:22:40Z biological_process owl:Class GO:0097580 biolink:NamedThing intracellular sequestering of copper ion The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system. got7fsn_ti intracellular retention of copper ion|intracellular storage of copper ion|intracellular copper ion sequestering|intracellular copper ion storage|intracellular sequestration of copper ion|intracellular copper ion retention|intracellular copper ion sequestration pr 2014-02-28T11:21:39Z biological_process owl:Class GO:0051651 biolink:NamedThing maintenance of location in cell Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. got7fsn_ti retention within cell|sequestering within cell|cellular retention|storage within cell|cellular storage|intracellular retention|maintenance of intracellular localization|maintenance of localization in cell|maintenance of localization within cell|cellular sequestering|intracellular sequestering|maintenance of cellular localization|intracellular storage biological_process owl:Class GO:0046878 biolink:NamedThing positive regulation of saliva secretion Any process that activates or increases the frequency, rate or extent of the regulated release of saliva. got7fsn_ti up-regulation of saliva secretion|activation of saliva secretion|stimulation of saliva secretion|up regulation of saliva secretion|upregulation of saliva secretion biological_process owl:Class GO:0060456 biolink:NamedThing positive regulation of digestive system process Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. got7fsn_ti biological_process owl:Class GO:0016295 biolink:NamedThing myristoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate. got7fsn_ti myristoyl-ACP hydrolase activity|tetradecanoyl-ACP hydrolase activity|myristoyl-[acyl-carrier protein] hydrolase activity|tetradecanoyl-[acyl-carrier-protein] hydrolase activity RHEA:30123|EC:3.1.2.14|MetaCyc:RXN-10727|KEGG_REACTION:R08159 molecular_function owl:Class GO:0016297 biolink:NamedThing acyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid. got7fsn_ti acyl-ACP-hydrolase activity|acyl-acyl carrier protein hydrolase activity|acyl-ACP thioesterase activity|acyl-[acyl-carrier protein] hydrolase activity|acyl-ACP hydrolase activity|acyl-acyl-carrier-protein hydrolase activity|S-acyl fatty acid synthase thioesterase activity GO:0010281 Reactome:R-HSA-5655955|EC:3.1.2.14|RHEA:30131|MetaCyc:RXN-7902 molecular_function owl:Class GO:0090194 biolink:NamedThing negative regulation of glomerulus development Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. got7fsn_ti tb 2009-12-18T11:17:13Z biological_process owl:Class GO:0090185 biolink:NamedThing negative regulation of kidney development Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti negative regulation of nephrogenesis tb 2009-12-18T10:58:45Z biological_process owl:Class GO:0016275 biolink:NamedThing [cytochrome c]-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine. got7fsn_ti cytochrome c-arginine N-methyltransferase activity|S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea|S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea RHEA:21872|EC:2.1.1.124|MetaCyc:2.1.1.124-RXN molecular_function owl:Class GO:0016274 biolink:NamedThing protein-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. got7fsn_ti PRMT activity Reactome:R-HSA-5229203|Reactome:R-HSA-5205798|Reactome:R-HSA-8879123|Reactome:R-HSA-191790|Reactome:R-HSA-5205820|Reactome:R-HSA-5205824|Reactome:R-HSA-5205822|Reactome:R-HSA-5229010|Reactome:R-HSA-5218952|Reactome:R-HSA-8934735|Reactome:R-HSA-5661126|Reactome:R-HSA-5205867 molecular_function owl:Class GO:1990711 biolink:NamedThing beta-catenin-ICAT complex Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex. got7fsn_ti Beta-catenin-ICAT complex|CTNNB1-CTNNBIP1 complex An example of this is Catenin beta-1 in human (UniProt symbol P35222) in PMID:12408824 (inferred from physical interaction). bhm 2015-03-25T21:08:11Z cellular_component owl:Class GO:0090571 biolink:NamedThing RNA polymerase II transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter. got7fsn_ti tb 2014-05-09T13:26:16Z cellular_component owl:Class GO:0070275 biolink:NamedThing aerobic ammonia oxidation to nitrite via pyruvic oxime The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite. got7fsn_ti MetaCyc:PWY-2242 biological_process owl:Class GO:0019329 biolink:NamedThing ammonia oxidation The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons. got7fsn_ti biological_process owl:Class GO:1990751 biolink:NamedThing Schwann cell chemotaxis The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti sl 2015-05-21T19:19:09Z biological_process owl:Class GO:0036135 biolink:NamedThing Schwann cell migration The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function. got7fsn_ti bf 2012-03-06T10:44:39Z biological_process owl:Class GO:0033043 biolink:NamedThing regulation of organelle organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. got7fsn_ti regulation of organelle organisation|regulation of organelle organization and biogenesis biological_process owl:Class GO:0051128 biolink:NamedThing regulation of cellular component organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. got7fsn_ti regulation of cellular component organisation|regulation of cell organization|regulation of cellular component organization and biogenesis|regulation of cell organisation biological_process owl:Class GO:0031128 biolink:NamedThing developmental induction A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). got7fsn_ti biological_process owl:Class GO:0042925 biolink:NamedThing benzoate transmembrane transporter activity Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other. got7fsn_ti benzoate transporter activity RHEA:32811 molecular_function owl:Class GO:0052877 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor. got7fsn_ti EC:1.4.9.- molecular_function owl:Class GO:0060508 biolink:NamedThing lung basal cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell. got7fsn_ti pulmonary basal cell differentiation biological_process owl:Class GO:0060479 biolink:NamedThing lung cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti pulmonary cell differentiation biological_process owl:Class GO:0003949 biolink:NamedThing 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. got7fsn_ti 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity|N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity|N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity|1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity|phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity|phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity EC:5.3.1.16|RHEA:15469|KEGG_REACTION:R04640|MetaCyc:PRIBFAICARPISOM-RXN molecular_function owl:Class GO:0033473 biolink:NamedThing indoleacetic acid conjugate metabolic process The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule. got7fsn_ti IAA conjugate metabolic process|indole acetic acid conjugate metabolic process|indole acetic acid conjugate metabolism|indoleacetic acid conjugate metabolism biological_process owl:Class GO:0009683 biolink:NamedThing indoleacetic acid metabolic process The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants. got7fsn_ti indole acetic acid metabolism|IAA metabolic process|indoleacetic acid metabolism|indole acetic acid metabolic process biological_process owl:Class GO:0071736 biolink:NamedThing IgG immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti IgG2a antibody|IgG2b antibody|IgG4 antibody|IgG3 antibody|IgG2 antibody|IgG antibody|IgG1 antibody|IgG2c antibody Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. mah 2010-03-24T01:44:53Z cellular_component owl:Class GO:0006336 biolink:NamedThing DNA replication-independent nucleosome assembly The formation of nucleosomes outside the context of DNA replication. got7fsn_ti transcription-coupled nucleosome assembly biological_process owl:Class GO:0034724 biolink:NamedThing DNA replication-independent nucleosome organization The formation or destruction of chromatin structures, occurring outside the context of DNA replication. got7fsn_ti DNA replication-independent nucleosome organisation biological_process owl:Class GO:0009039 biolink:NamedThing urease activity Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. got7fsn_ti urea amidohydrolase activity MetaCyc:UREASE-RXN|UM-BBD_reactionID:r0120|RHEA:20557|EC:3.5.1.5 molecular_function owl:Class GO:0010214 biolink:NamedThing seed coat development The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class GO:0034645 biolink:NamedThing cellular macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. got7fsn_ti cellular macromolecule biosynthesis|cellular macromolecule formation|cellular macromolecule anabolism|cellular biopolymer biosynthetic process|cellular macromolecule synthesis GO:0034961 biological_process owl:Class GO:0009059 biolink:NamedThing macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biopolymer biosynthetic process|macromolecule biosynthesis|macromolecule synthesis|macromolecule anabolism|macromolecule formation GO:0043284 biological_process owl:Class GO:0008719 biolink:NamedThing dihydroneopterin triphosphate 2'-epimerase activity Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate. got7fsn_ti D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity EC:5.1.99.7|MetaCyc:H2NTPEPIM-RXN|RHEA:28346 molecular_function owl:Class GO:0090724 biolink:NamedThing central region of growth cone The center of the migrating motile tip of a growing nerve cell axon or dendrite. got7fsn_ti tb 2016-11-18T12:44:25Z cellular_component owl:Class GO:0103078 biolink:NamedThing quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP. got7fsn_ti RHEA:61184|MetaCyc:RXNQT-4162 molecular_function owl:Class GO:0000412 biolink:NamedThing histone peptidyl-prolyl isomerization The modification of a histone by cis-trans isomerization of a proline residue. got7fsn_ti histone proline isomerization biological_process owl:Class GO:0034359 biolink:NamedThing mature chylomicron A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph. got7fsn_ti cellular_component owl:Class GO:0042627 biolink:NamedThing chylomicron A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. got7fsn_ti Wikipedia:Chylomicron cellular_component owl:Class GO:0031805 biolink:NamedThing type 8 metabotropic glutamate receptor binding Binding to a type 8 metabotropic glutamate receptor. got7fsn_ti type 8 metabotropic glutamate receptor ligand molecular_function owl:Class GO:0047717 biolink:NamedThing imidazoleacetate 4-monooxygenase activity Catalysis of the reaction: H(+) + imidazol-4-ylacetate + NADH + O(2) = 5-hydroxyimidazole-4-acetate + H(2)O + NAD(+). got7fsn_ti 4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)|imidazoleacetic hydroxylase activity|imidazoleacetic monooxygenase activity|imidazoleacetate hydroxylase activity KEGG_REACTION:R04066|RHEA:19425|MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN|EC:1.14.13.5 molecular_function owl:Class GO:0052833 biolink:NamedThing inositol monophosphate 4-phosphatase activity Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate. got7fsn_ti inositol-1(or 4)-monophosphatase activity|myo-inositol-1(or 4)-monophosphatase activity|myo-inositol-1(or 4)-phosphate phosphohydrolase activity ai 2011-11-29T11:02:15Z RHEA:30735|Reactome:R-HSA-1855211|MetaCyc:RXN-10952|EC:3.1.3.25 molecular_function owl:Class GO:0052834 biolink:NamedThing inositol monophosphate phosphatase activity Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate. got7fsn_ti inositol-phosphate phosphatase activity|myo-inositol-phosphatase activity|inositol phosphatase activity|inositol-1(or 4)-monophosphatase activity|myo-inositol phosphatase activity|L-myo-inositol-phosphate phosphatase activity|myo-inositol-phosphate phosphohydrolase activity|myo-inositol monophosphatase activity|myo-inositol-1(or 4)-phosphate phosphohydrolase activity ai 2011-11-29T11:15:58Z EC:3.1.3.25|RHEA:24056|MetaCyc:RXN-10949 molecular_function owl:Class GO:0035372 biolink:NamedThing protein localization to microtubule A process in which a protein is transported to, or maintained at, a microtubule. got7fsn_ti protein localisation to microtubule bf 2010-03-11T11:00:56Z biological_process owl:Class GO:0072698 biolink:NamedThing protein localization to microtubule cytoskeleton A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. got7fsn_ti protein localisation to microtubule cytoskeleton mah 2012-04-11T01:19:35Z biological_process owl:Class GO:0021853 biolink:NamedThing cerebral cortex GABAergic interneuron migration The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. got7fsn_ti biological_process owl:Class GO:0021830 biolink:NamedThing interneuron migration from the subpallium to the cortex The directed movement of interneurons from the subpallium to the cortex during forebrain development. got7fsn_ti biological_process owl:Class GO:0014023 biolink:NamedThing neural rod formation The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. got7fsn_ti biological_process owl:Class GO:0097665 biolink:NamedThing SCF-Mdm30 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Mdm30 in S. cerevisiae. got7fsn_ti pr 2014-10-06T10:27:30Z cellular_component owl:Class GO:1901511 biolink:NamedThing (-)-microperfuranone catabolic process The chemical reactions and pathways resulting in the breakdown of (-)-microperfuranone. got7fsn_ti (-)-microperfuranone catabolism|(-)-microperfuranone degradation|(-)-microperfuranone breakdown di 2012-10-18T06:54:14Z biological_process owl:Class GO:1901502 biolink:NamedThing ether catabolic process The chemical reactions and pathways resulting in the breakdown of ether. got7fsn_ti ether breakdown|ether degradation|ether catabolism pr 2012-10-17T09:42:43Z biological_process owl:Class GO:0035477 biolink:NamedThing regulation of angioblast cell migration involved in selective angioblast sprouting Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting. got7fsn_ti bf 2010-04-23T10:08:28Z biological_process owl:Class GO:1901342 biolink:NamedThing regulation of vasculature development Any process that modulates the frequency, rate or extent of vasculature development. got7fsn_ti regulation of vascular system development bf 2012-09-06T09:16:15Z biological_process owl:Class GO:0018039 biolink:NamedThing C-terminal peptidyl-glutamine amidation The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0086 biological_process owl:Class GO:0018199 biolink:NamedThing peptidyl-glutamine modification The modification of peptidyl-glutamine. got7fsn_ti biological_process owl:Class GO:0050362 biolink:NamedThing L-tryptophan:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate. got7fsn_ti tryptophan aminotransferase activity|L-tryptophan transaminase activity|tryptophan transaminase activity|hydroxytryptophan aminotransferase activity|L-phenylalanine-2-oxoglutarate aminotransferase activity|L-tryptophan aminotransferase activity|5-hydroxytryptophan-ketoglutaric transaminase activity MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN|RHEA:14093|EC:2.6.1.27 molecular_function owl:Class GO:0120136 biolink:NamedThing dUMP kinase activity Catalysis of the reaction: ATP + dUMP = ADP + dUDP. got7fsn_ti dUMP-kinase activity|ATP:dUMP phosphotransferase activity|deoxyuridine monophosphate kinase activity krc 2018-03-21T21:16:06Z RHEA:30655 molecular_function owl:Class GO:0018655 biolink:NamedThing 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA. got7fsn_ti UM-BBD_reactionID:r0430|EC:1.14.13.- molecular_function owl:Class GO:0004771 biolink:NamedThing sterol esterase activity Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. got7fsn_ti acylcholesterol lipase activity|cholesteryl ester hydrolase activity|cholesterol esterase activity|cholesterol ester synthase activity|cholesterase activity|cholesterol ester hydrolase activity|cholesteryl esterase activity|triterpenol esterase activity|sterol ester hydrolase activity|steryl-ester acylhydrolase activity|cholesteryl ester synthase activity EC:3.1.1.13|RHEA:10100|Reactome:R-HSA-6813720|Reactome:R-HSA-8865667|Reactome:R-HSA-192417|MetaCyc:STEROL-ESTERASE-RXN molecular_function owl:Class GO:0007280 biolink:NamedThing pole cell migration The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form. got7fsn_ti See also the Cell Ontology term 'pole cell ; CL:0000301'. biological_process owl:Class GO:0008354 biolink:NamedThing germ cell migration The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. got7fsn_ti primordial germ cell migration|germ-cell migration biological_process owl:Class GO:0031316 biolink:NamedThing extrinsic component of nuclear outer membrane The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to nuclear outer membrane cellular_component owl:Class GO:0048709 biolink:NamedThing oligodendrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. got7fsn_ti biological_process owl:Class GO:0010001 biolink:NamedThing glial cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. got7fsn_ti neuroglia differentiation|glia cell differentiation GO:0043360|GO:0007404 biological_process owl:Class GO:0071185 biolink:NamedThing protocadherin-alpha-v4-protocadherin-gamma-a3 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti Pcdhga1-Pcdhga3 complex mah 2009-11-23T04:16:47Z cellular_component owl:Class GO:0071183 biolink:NamedThing protocadherin-alpha-protocadherin-gamma complex A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti mah 2009-11-23T04:10:30Z cellular_component owl:Class GO:0004609 biolink:NamedThing phosphatidylserine decarboxylase activity Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine. got7fsn_ti PS decarboxylase activity|phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)|phosphatidyl-L-serine carboxy-lyase activity Reactome:R-HSA-1483212|RHEA:20828|EC:4.1.1.65|KEGG_REACTION:R02055|MetaCyc:PHOSPHASERDECARB-RXN molecular_function owl:Class GO:0120120 biolink:NamedThing bilobe structure A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone). got7fsn_ti kinetoplastid flagellar hook complex Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. krc 2017-12-11T23:47:20Z cellular_component owl:Class GO:0120197 biolink:NamedThing mucociliary clearance The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways. got7fsn_ti MCT|MCC|mucociliary transport krc 2019-04-26T16:16:50Z biological_process owl:Class GO:0003351 biolink:NamedThing epithelial cilium movement involved in extracellular fluid movement The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid. got7fsn_ti cilium movement involved in fluid flow|epithelial cilium beating dph 2009-12-03T10:08:25Z biological_process owl:Class GO:0042390 biolink:NamedThing gibberellic acid mediated signaling pathway, G-alpha-independent A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors. got7fsn_ti gibberellic acid mediated signalling, G-alpha-independent biological_process owl:Class GO:0009740 biolink:NamedThing gibberellic acid mediated signaling pathway A series of molecular signals mediated by the detection of gibberellic acid. got7fsn_ti GA-signaling|gibberellic acid signaling|gibberellic acid mediated signalling biological_process owl:Class GO:0048717 biolink:NamedThing anterior cibarial plate morphogenesis The process in which the anatomical structures of the anterior cibarial plate are generated and organized. got7fsn_ti biological_process owl:Class GO:1990403 biolink:NamedThing embryonic brain development The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure. got7fsn_ti sl 2014-06-23T20:57:13Z biological_process owl:Class GO:0018204 biolink:NamedThing peptidyl-leucine modification The modification of peptidyl-leucine. got7fsn_ti biological_process owl:Class GO:0018193 biolink:NamedThing peptidyl-amino acid modification The alteration of an amino acid residue in a peptide. got7fsn_ti biological_process owl:Class GO:0046355 biolink:NamedThing mannan catabolic process The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. got7fsn_ti mannan degradation|mannan catabolism|mannan breakdown biological_process owl:Class GO:0044247 biolink:NamedThing cellular polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells. got7fsn_ti cellular polysaccharide degradation|cellular polysaccharide catabolism|cellular polysaccharide breakdown biological_process owl:Class GO:0052334 biolink:NamedThing modification by organism of cytoskeleton of other organism involved in symbiotic interaction The process in which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modification by organism of cytoskeleton of other organism during symbiotic interaction biological_process owl:Class GO:0052188 biolink:NamedThing modification of cellular component in other organism involved in symbiotic interaction The process in which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modification of cellular component in other organism during symbiotic interaction biological_process owl:Class GO:0035933 biolink:NamedThing glucocorticoid secretion The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood. got7fsn_ti bf 2011-07-20T01:08:37Z biological_process owl:Class GO:0035930 biolink:NamedThing corticosteroid hormone secretion The regulated release of any corticosteroid hormone into the circulatory system. got7fsn_ti corticosteroid secretion bf 2011-07-20T01:03:22Z biological_process owl:Class GO:0072261 biolink:NamedThing metanephric extraglomerular mesangial cell proliferation involved in metanephros development The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. got7fsn_ti metanephric lacis cell proliferation|metanephric Goormaghtigh proliferation mah 2010-03-30T02:14:17Z biological_process owl:Class GO:0072122 biolink:NamedThing extraglomerular mesangial cell proliferation The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. got7fsn_ti Goormaghtigh proliferation|lacis cell proliferation mah 2010-02-22T01:42:23Z biological_process owl:Class GO:0016445 biolink:NamedThing somatic diversification of immunoglobulins The somatic process that results in the generation of sequence diversity of immunoglobulins. got7fsn_ti somatic diversification of antibodies biological_process owl:Class GO:0002200 biolink:NamedThing somatic diversification of immune receptors The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. got7fsn_ti Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. biological_process owl:Class GO:0033758 biolink:NamedThing clavaminate synthase activity Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O. got7fsn_ti clavaminate synthase 2 activity|clavaminic acid synthase activity|deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity RHEA:20021|EC:1.14.11.21|MetaCyc:1.14.11.21-RXN molecular_function owl:Class GO:0061055 biolink:NamedThing myotome development The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. got7fsn_ti dph 2010-03-02T12:11:01Z biological_process owl:Class GO:1901343 biolink:NamedThing negative regulation of vasculature development Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. got7fsn_ti inhibition of vasculature development|down regulation of vasculature development|downregulation of vasculature development|inhibition of vascular system development|downregulation of vascular system development|down regulation of vascular system development|down-regulation of vascular system development|down-regulation of vasculature development|negative regulation of vascular system development bf 2012-09-06T09:17:24Z biological_process owl:Class GO:0000238 biolink:NamedThing zygotene The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Meiosis#Zygotene|Wikipedia:Zygotene biological_process owl:Class GO:0098764 biolink:NamedThing meiosis I cell cycle phase A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class GO:0050633 biolink:NamedThing acetyl-CoA C-myristoyltransferase activity Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA. got7fsn_ti myristoyl-CoA C-acetyltransferase activity|3-oxopalmitoyl-CoA hydrolase activity|3-oxopalmitoyl-CoA-CoA acetyltransferase activity|myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity MetaCyc:2.3.1.155-RXN|RHEA:18161|EC:2.3.1.155 molecular_function owl:Class GO:0016408 biolink:NamedThing C-acyltransferase activity Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class GO:0031522 biolink:NamedThing cell envelope Sec protein transport complex A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC. got7fsn_ti Sec translocation complex|Sec complex|Sec secretion complex|plasma membrane Sec complex Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'. cellular_component owl:Class GO:0030258 biolink:NamedThing lipid modification The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. got7fsn_ti biological_process owl:Class GO:0006506 biolink:NamedThing GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. got7fsn_ti glycosylphosphatidylinositol biosynthetic process|GPI anchor biosynthesis|GPI anchor formation|glycosylphosphatidylinositol biosynthesis|GPI anchor anabolism|GPI/GSI anchor biosynthesis|GPI/GSI anchor biosynthetic process|GPI anchor synthesis GO:0015998 biological_process owl:Class GO:0006497 biolink:NamedThing protein lipidation The covalent attachment of lipid groups to an amino acid in a protein. got7fsn_ti protein amino acid lipidation|lipid:protein modification For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children. GO:0042050 RESID:AA0104|RESID:AA0159|RESID:AA0078|RESID:AA0162|RESID:AA0080|RESID:AA0106|RESID:AA0158|RESID:AA0060|RESID:AA0079|RESID:AA0307|RESID:AA0077|RESID:AA0309|RESID:AA0102|RESID:AA0308|RESID:AA0059|RESID:AA0163|RESID:AA0160|RESID:AA0161|RESID:AA0103|RESID:AA0107|RESID:AA0316|RESID:AA0166|RESID:AA0290|RESID:AA0223 biological_process owl:Class GO:0003425 biolink:NamedThing establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate. got7fsn_ti dph 2009-12-22T10:36:36Z biological_process owl:Class GO:0090176 biolink:NamedThing microtubule cytoskeleton organization involved in establishment of planar polarity A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity. got7fsn_ti microtubule cytoskeleton organisation involved in establishment of planar polarity tb 2009-12-14T10:34:25Z biological_process owl:Class GO:0047649 biolink:NamedThing alkylglycerol kinase activity Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H(+). got7fsn_ti 1-alkylglycerol kinase (phosphorylating)|alkylglycerol phosphotransferase activity|ATP:1-alkyl-sn-glycerol phosphotransferase activity|ATP-alkylglycerol phosphotransferase activity|ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity MetaCyc:ALKYLGLYCEROL-KINASE-RXN|EC:2.7.1.93|KEGG_REACTION:R04126|RHEA:16937 molecular_function owl:Class GO:0050578 biolink:NamedThing (R)-2-hydroxyacid dehydrogenase activity Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+. got7fsn_ti L-sulfolactate dehydrogenase activity|(R)-sulfolactate:NAD(P)(+) oxidoreductase activity|(R)-sulfolactate:NAD(P)+ oxidoreductase activity|(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity RHEA:35735|MetaCyc:1.1.1.272-RXN|EC:1.1.1.272 molecular_function owl:Class GO:0000746 biolink:NamedThing conjugation The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms. got7fsn_ti Wikipedia:Conjugation biological_process owl:Class GO:0044764 biolink:NamedThing multi-organism cellular process Any process that is carried out at the cellular level which involves another organism of the same or different species. got7fsn_ti jl 2012-12-11T17:00:50Z biological_process owl:Class GO:0097345 biolink:NamedThing mitochondrial outer membrane permeabilization The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway. got7fsn_ti mitochondrial outer membrane permeabilization during apoptotic cell death|mitochondrion outer membrane permeabilization|MOMP|mitochondrial outer membrane permeabilization BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively). pr 2012-06-19T04:06:54Z biological_process owl:Class GO:1902110 biolink:NamedThing positive regulation of mitochondrial membrane permeability involved in apoptotic process Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process. got7fsn_ti positive regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity|positive regulation of transport across mitochondrial membrane involved in type I programmed cell death|mitochondrial membrane permeability transition involved in type I programmed cell death|positive regulation of mitochondrial membrane permeability involved in apoptotic cell death|positive regulation of transport across mitochondrial membrane involved in apoptotic cell death|mitochondrial permeability transition involved in apoptotic cell death|mitochondrial permeability transition involved in apoptosis|mitochondrial membrane permeabilization involved in apoptotic programmed cell death|mitochondrial membrane permeability transition involved in apoptotic process|mitochondrial membrane permeabilization involved in signaling (initiator) caspase activity|mitochondrial permeability transition involved in apoptotic programmed cell death|mitochondrial membrane permeabilization involved in apoptotic process|positive regulation of mitochondrial membrane permeability involved in apoptotic program|positive regulation of transport across mitochondrial membrane involved in apoptotic program|positive regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis|mitochondrial permeability transition involved in signaling (initiator) caspase activity|mitochondrial membrane permeability transition involved in signaling (initiator) caspase activity|mitochondrial membrane permeability transition involved in apoptotic cell death|mitochondrial membrane permeabilization involved in programmed cell death by apoptosis|positive regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death|positive regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis|mitochondrial permeability transition involved in type I programmed cell death|positive regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity|mitochondrial membrane permeability transition involved in apoptosis|mitochondrial membrane permeability transition involved in programmed cell death by apoptosis|positive regulation of transport across mitochondrial membrane involved in apoptosis|positive regulation of mitochondrial membrane permeability involved in apoptosis|mitochondrial permeability transition involved in apoptotic program|positive regulation of transport across mitochondrial membrane involved in apoptotic process|mitochondrial membrane permeabilization involved in type I programmed cell death|mitochondrial permeability transition involved in programmed cell death by apoptosis|mitochondrial membrane permeabilization involved in apoptotic program|mitochondrial membrane permeability transition involved in apoptotic program|mitochondrial membrane permeabilization involved in apoptosis|positive regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death|positive regulation of mitochondrial membrane permeability involved in type I programmed cell death|mitochondrial permeability transition involved in apoptotic process|mitochondrial membrane permeabilization involved in apoptotic cell death|mitochondrial membrane permeability transition involved in apoptotic programmed cell death Individual components of the mitochondrial permeability transition pore complex, such as the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D), are involved in this process. pr 2013-05-03T12:13:56Z biological_process owl:Class GO:0033277 biolink:NamedThing abortive mitotic cell cycle A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy. got7fsn_ti abortive mitosis Note that this term should be used only for abortive mitotic events that occur normally, e.g. during megakaryocyte differentiation; it should not be used for incomplete mitosis resulting from mutation or other abnormal occurrences. Note that this term should not be confused with 'endomitotic cell cycle ; GO:0007113', which describes a process in which no mitotic spindle forms. biological_process owl:Class GO:0000278 biolink:NamedThing mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. got7fsn_ti mitosis Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. GO:0007067 Wikipedia:Mitosis biological_process owl:Class GO:0000721 biolink:NamedThing (R,R)-butanediol dehydrogenase activity Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+). got7fsn_ti 2,3-butanediol dehydrogenase activity|1-amino-2-propanol dehydrogenase activity|butyleneglycol dehydrogenase activity|1-amino-2-propanol oxidoreductase activity|D-1-amino-2-propanol:NAD(2) oxidoreductase activity|(R)-diacetyl reductase activity|D-aminopropanol dehydrogenase activity|D-butanediol dehydrogenase activity|D-(-)-butanediol dehydrogenase activity|aminopropanol oxidoreductase activity|butylene glycol dehydrogenase activity|D-1-amino-2-propanol dehydrogenase activity|diacetyl (acetoin) reductase activity|(R)-2,3-butanediol dehydrogenase activity MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN|EC:1.1.1.4|RHEA:24340 molecular_function owl:Class GO:0047175 biolink:NamedThing galactosylacylglycerol O-acyltransferase activity Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]. got7fsn_ti acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity|acyl-ACP:lyso-MGDG acyltransferase activity|acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity RHEA:17057|MetaCyc:2.3.1.141-RXN|EC:2.3.1.141 molecular_function owl:Class GO:0036481 biolink:NamedThing intrinsic apoptotic signaling pathway in response to hydrogen peroxide A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2). got7fsn_ti hydrogen peroxide-induced apoptosis|H2O2-induced intrinsic apoptotic signaling pathway|hydrogen peroxide-induced intrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway in response to H2O2 bf 2014-08-14T13:19:21Z biological_process owl:Class GO:0008631 biolink:NamedThing intrinsic apoptotic signaling pathway in response to oxidative stress A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. got7fsn_ti oxidative stress-induced intrinsic apoptotic signaling pathway|induction of apoptosis by oxidative stress biological_process owl:Class GO:0009510 biolink:NamedThing plasmodesmatal desmotubule A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell. got7fsn_ti desmotubule central rod GO:0009572 cellular_component owl:Class GO:0034969 biolink:NamedThing histone arginine methylation The modification of a histone by addition of a methyl group to an arginine residue. got7fsn_ti biological_process owl:Class GO:0016571 biolink:NamedThing histone methylation The modification of histones by addition of methyl groups. got7fsn_ti Wikipedia:Histone_methylation biological_process owl:Class GO:0140536 biolink:NamedThing nuclear receptor corepressor activity A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. got7fsn_ti nuclear corepressor activity https://github.com/geneontology/go-ontology/issues/20262|https://github.com/geneontology/go-ontology/issues/20464 For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. pg 2020-11-03T13:02:08Z molecular_function owl:Class GO:0003714 biolink:NamedThing transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. got7fsn_ti RNA polymerase II transcription corepressor activity|transcription corepressor activity|RNA polymerase II transcription co-repressor activity|transcription co-repressor activity https://github.com/geneontology/go-ontology/issues/20464|https://github.com/geneontology/go-ontology/issues/15665|https://github.com/geneontology/go-ontology/issues/15998 For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. krc 2010-11-24T03:14:44Z GO:0001106 molecular_function owl:Class GO:0050402 biolink:NamedThing xylono-1,4-lactonase activity Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate. got7fsn_ti xylonolactonase activity|xylono-g-lactonase activity|D-xylono-1,4-lactone lactonohydrolase activity RHEA:18341|EC:3.1.1.68|MetaCyc:XYLONO-14-LACTONASE-RXN molecular_function owl:Class GO:0060919 biolink:NamedThing auxin influx The process involved in the transport of auxin into the cell. got7fsn_ti dph 2009-09-28T02:49:18Z biological_process owl:Class GO:0060918 biolink:NamedThing auxin transport The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti dph 2009-09-28T02:44:54Z biological_process owl:Class GO:0021905 biolink:NamedThing forebrain-midbrain boundary formation The process whose specific outcome is the creation of the forebrain-midbrain boundary. got7fsn_ti biological_process owl:Class GO:0009308 biolink:NamedThing amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. got7fsn_ti amine metabolism biological_process owl:Class GO:0010411 biolink:NamedThing xyloglucan metabolic process The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants. got7fsn_ti xyloglucan metabolism biological_process owl:Class GO:0006073 biolink:NamedThing cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell. got7fsn_ti cellular glucan metabolism biological_process owl:Class GO:0052720 biolink:NamedThing class II DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. got7fsn_ti class II DNA-(apurinic or apyrimidinic site) lyase activity https://github.com/geneontology/go-ontology/issues/13409 Class II AP endonuclease is a nuclease, but not Class I, III and IV. pg 2017-07-24T11:46:03Z GO:0140079 molecular_function owl:Class GO:0003906 biolink:NamedThing DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). got7fsn_ti apyrimidinic deoxyendoribonuclease activity|abasic deoxyendoribonuclease activity|deoxyribonuclease (apurinic or apyrimidinic) activity|AP deoxyendoribonuclease activity|UV endonuclease|apurinic deoxyendoribonuclease activity|apurinic/apyrimidinic endodeoxyribonuclease activity|endonuclease VIII activity Reactome:R-HSA-5649725|Reactome:R-HSA-5649711|Reactome:R-HSA-110375 molecular_function owl:Class GO:0005587 biolink:NamedThing collagen type IV trimer A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. got7fsn_ti Wikipedia:Collagen_type_IV cellular_component owl:Class GO:0098642 biolink:NamedThing network-forming collagen trimer A collagen trimer that forms networks. got7fsn_ti cellular_component owl:Class GO:0070381 biolink:NamedThing endosome to plasma membrane transport vesicle A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis. got7fsn_ti endosome to plasma membrane constitutive secretory pathway transport vesicle|endosome-plasma membrane transport vesicle cellular_component owl:Class GO:0070382 biolink:NamedThing exocytic vesicle A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. got7fsn_ti exocytic constitutive secretory pathway transport vesicle|exocytotic vesicle cellular_component owl:Class GO:0003217 biolink:NamedThing cardiac right atrium formation The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. got7fsn_ti dph 2009-10-13T09:53:12Z biological_process owl:Class GO:0003210 biolink:NamedThing cardiac atrium formation The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. got7fsn_ti dph 2009-10-13T09:44:25Z biological_process owl:Class GO:0080086 biolink:NamedThing stamen filament development The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen. got7fsn_ti filament development dhl 2009-04-22T03:12:03Z biological_process owl:Class GO:0042543 biolink:NamedThing protein N-linked glycosylation via arginine The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine. got7fsn_ti protein amino acid N-linked glycosylation via arginine RESID:AA0327 biological_process owl:Class GO:0018195 biolink:NamedThing peptidyl-arginine modification The modification of peptidyl-arginine. got7fsn_ti biological_process owl:Class GO:1990424 biolink:NamedThing protein arginine kinase activity Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate. got7fsn_ti This reaction occurs in bacterial species e.g. Bacillus subtilis. jl 2014-07-23T13:35:56Z molecular_function owl:Class GO:0004672 biolink:NamedThing protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. got7fsn_ti protamine kinase activity Note that triphosphate is used as a phosphate donor by at least one kinase. GO:0050222 MetaCyc:PROTEIN-KINASE-RXN|Reactome:R-HSA-937034|Reactome:R-HSA-9604606|Reactome:R-HSA-9673284|Reactome:R-HSA-156832|Reactome:R-HSA-975139 molecular_function owl:Class GO:0070427 biolink:NamedThing nucleotide-binding oligomerization domain containing 1 signaling pathway Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 1 (NOD1). got7fsn_ti nucleotide-binding oligomerization domain containing 1 signalling pathway|NOD1 signaling pathway biological_process owl:Class GO:0070423 biolink:NamedThing nucleotide-binding oligomerization domain containing signaling pathway Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein. got7fsn_ti NOD signaling pathway|nucleotide-binding oligomerization domain containing signalling pathway biological_process owl:Class GO:0003022 biolink:NamedThing detection of pH by chemoreceptor signaling The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors. got7fsn_ti detection of pH by chemoreceptor signalling biological_process owl:Class GO:0003030 biolink:NamedThing detection of hydrogen ion The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class GO:1990431 biolink:NamedThing priRNA 3'-end processing The process of forming the mature 3' end of a priRNA molecule. got7fsn_ti primal small RNA 3'-end processing|priRNA 3' end processing jl 2014-07-29T15:34:19Z biological_process owl:Class GO:0043628 biolink:NamedThing ncRNA 3'-end processing Any process involved in forming the mature 3' end of a non-coding RNA molecule. got7fsn_ti ncRNA 3' end processing biological_process owl:Class GO:0016580 biolink:NamedThing Sin3 complex A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. got7fsn_ti cellular_component owl:Class GO:0070822 biolink:NamedThing Sin3-type complex Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. got7fsn_ti mah 2009-07-20T04:32:33Z cellular_component owl:Class GO:0046455 biolink:NamedThing organosilicon catabolic process The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon. got7fsn_ti organosilicon catabolism|organosilicon degradation|organosilicone catabolic process|organosilicone catabolism|organosilicon breakdown biological_process owl:Class GO:0042178 biolink:NamedThing xenobiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti exogenous drug catabolic process|drug catabolic process|exogenous drug catabolism|exogenous drug breakdown|drug degradation|drug catabolism|xenobiotic degradation|drug breakdown|exogenous drug degradation|xenobiotic breakdown|xenobiotic catabolism https://github.com/geneontology/go-ontology/issues/19460 GO:0042737|GO:0042738 biological_process owl:Class GO:0035082 biolink:NamedThing axoneme assembly The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. got7fsn_ti ciliary axoneme assembly|flagellar axoneme assembly|cilium axoneme assembly|axoneme biogenesis|cilium axoneme biogenesis|flagellum axoneme assembly Note that cilia and eukaryotic flagella are deemed to be equivalent. GO:0035083|GO:0035084 biological_process owl:Class GO:0001578 biolink:NamedThing microtubule bundle formation A process that results in a parallel arrangement of microtubules. got7fsn_ti microtubule bundling biological_process owl:Class GO:0043209 biolink:NamedThing myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. got7fsn_ti astrocyte sheath|Schwann cell myelin sheath|oligodendrocyte myelin sheath NIF_Subcellular:sao593830697|FMA:62983|Wikipedia:Myelin cellular_component owl:Class GO:0043367 biolink:NamedThing CD4-positive, alpha-beta T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. got7fsn_ti CD4-positive, alpha-beta T-cell differentiation|CD4-positive, alpha-beta T lymphocyte differentiation|CD4-positive, alpha beta T cell development|CD4-positive, alpha-beta T-lymphocyte differentiation|CD4-positive, alpha beta T cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:0035710 biolink:NamedThing CD4-positive, alpha-beta T cell activation The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti bf 2011-03-02T03:04:11Z biological_process owl:Class GO:0051881 biolink:NamedThing regulation of mitochondrial membrane potential Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti biological_process owl:Class GO:0008024 biolink:NamedThing cyclin/CDK positive transcription elongation factor complex A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. got7fsn_ti positive transcription elongation factor complex b See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. cellular_component owl:Class GO:0032806 biolink:NamedThing carboxy-terminal domain protein kinase complex A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. got7fsn_ti CTDK complex cellular_component owl:Class GO:0047349 biolink:NamedThing D-ribitol-5-phosphate cytidylyltransferase activity Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate. got7fsn_ti CTP:D-ribitol-5-phosphate cytidylyltransferase activity|ribitol 5-phosphate cytidylyltransferase activity|cytidine diphosphoribitol pyrophosphorylase activity|CDP-ribitol diphosphorylase activity|CDP ribitol pyrophosphorylase activity|CDP-ribitol pyrophosphorylase activity|cytidine diphosphate ribitol pyrophosphorylase activity KEGG_REACTION:R02921|EC:2.7.7.40|RHEA:12456|MetaCyc:2.7.7.40-RXN molecular_function owl:Class GO:0070567 biolink:NamedThing cytidylyltransferase activity Catalysis of the transfer of a cytidylyl group to an acceptor. got7fsn_ti mah 2009-04-15T11:05:22Z molecular_function owl:Class GO:0072038 biolink:NamedThing mesenchymal stem cell maintenance involved in nephron morphogenesis The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti mah 2010-01-25T03:08:05Z biological_process owl:Class GO:0035019 biolink:NamedThing somatic stem cell population maintenance Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. got7fsn_ti biological_process owl:Class GO:0061771 biolink:NamedThing response to caloric restriction A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake. got7fsn_ti dph 2016-07-09T09:40:32Z biological_process owl:Class GO:0006950 biolink:NamedThing response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti response to biotic stress|response to abiotic stress Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0008544 biolink:NamedThing epidermis development The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. got7fsn_ti hypodermis development biological_process owl:Class GO:0009888 biolink:NamedThing tissue development The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. got7fsn_ti histogenesis|histogenesis and organogenesis Wikipedia:Histogenesis biological_process owl:Class GO:0036409 biolink:NamedThing histone H3-K14 acetyltransferase complex A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3. got7fsn_ti histone acetyltransferase complex (H3-K14 specific)|histone H3 Lys 14 (H3K14) acetyltransferase complex|H3-K14 histone acetyltransferase complex|histone H3K14 acetyltransferase complex bf 2013-08-21T10:06:34Z cellular_component owl:Class GO:0070775 biolink:NamedThing H3 histone acetyltransferase complex A multisubunit complex that catalyzes the acetylation of histone H3. got7fsn_ti H3 HAT complex mah 2009-07-02T11:56:48Z cellular_component owl:Class GO:0015013 biolink:NamedThing heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan. got7fsn_ti heparan sulfate proteoglycan synthesis, linkage to polypeptide|heparin proteoglycan biosynthetic process, linkage to polypeptide|heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide|heparan sulfate proteoglycan formation, linkage to polypeptide|heparan sulfate proteoglycan anabolism, linkage to polypeptide|heparan sulphate proteoglycan biosynthesis, linkage to polypeptide biological_process owl:Class GO:0018242 biolink:NamedThing protein O-linked glycosylation via serine The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine. got7fsn_ti protein amino acid O-linked glycosylation via serine RESID:AA0154 biological_process owl:Class GO:0035568 biolink:NamedThing N-terminal peptidyl-proline methylation The methylation of the N-terminal proline of proteins. got7fsn_ti bf 2010-08-06T01:52:43Z RESID:AA0419 biological_process owl:Class GO:0006480 biolink:NamedThing N-terminal protein amino acid methylation The methylation of the N-terminal amino acid of a protein. got7fsn_ti biological_process owl:Class GO:0071914 biolink:NamedThing prominosome An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known. got7fsn_ti prominin-containing extracellular membrane vesicle mah 2010-09-24T09:24:36Z cellular_component owl:Class GO:1903561 biolink:NamedThing extracellular vesicle Any vesicle that is part of the extracellular region. got7fsn_ti microparticle jl 2014-10-22T14:26:11Z cellular_component owl:Class GO:0099000 biolink:NamedThing viral genome ejection through host cell envelope, contractile tail mechanism Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope. got7fsn_ti viral contractile tail ejection system VZ:3950 biological_process owl:Class GO:0039678 biolink:NamedThing viral genome ejection through host cell envelope Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm. got7fsn_ti viral genome injection through bacterial membranes|phage genome ejection When a pore-forming protein is involved, see also 'pore-mediated entry of viral genome into host cell ; GO:0044694'. bf 2013-09-26T11:56:48Z biological_process owl:Class GO:0004991 biolink:NamedThing parathyroid hormone receptor activity Combining with parathyroid hormone to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class GO:0043494 biolink:NamedThing CLRC complex An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi. got7fsn_ti Rik1-E3 ubiquitin ligase complex|Clr4-Rik1-Cul4 complex|CLRC ubiquitin ligase complex|Rik1 E3 ubiquitin ligase complex cellular_component owl:Class GO:0031465 biolink:NamedThing Cul4B-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits. got7fsn_ti cullin-RING ligase 4B cellular_component owl:Class GO:0015667 biolink:NamedThing site-specific DNA-methyltransferase (cytosine-N4-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine. got7fsn_ti m4C-forming MTase activity|N(4)-cytosine-specific DNA methylase activity|N4-cytosine-specific DNA methylase activity|restriction-modification system activity|modification methylase activity|S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity|S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity|DNA[cytosine-N4]methyltransferase activity RHEA:16857|MetaCyc:2.1.1.113-RXN|EC:2.1.1.113 molecular_function owl:Class GO:1990440 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. got7fsn_ti ER stress-induced upregulation of transcription|up-regulation of transcription induced by ER stress|activation of transcription from RNA polymerase II promoter in response to ER stress|up-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|upregulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|upregulation of Pol II transcription induced by ER stress|stimulation of transcription from RNA polymerase II promoter in response to ER stress bf 2014-07-31T12:56:54Z biological_process owl:Class GO:0036003 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to stress Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti bf 2011-09-19T03:00:18Z biological_process owl:Class GO:1902106 biolink:NamedThing negative regulation of leukocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. got7fsn_ti down regulation of leukocyte differentiation|down-regulation of leukocyte differentiation|negative regulation of immune cell differentiation|inhibition of leucocyte differentiation|down regulation of immune cell differentiation|down-regulation of leucocyte differentiation|negative regulation of leucocyte differentiation|down regulation of leucocyte differentiation|downregulation of leukocyte differentiation|inhibition of leukocyte differentiation|downregulation of immune cell differentiation|inhibition of immune cell differentiation|down-regulation of immune cell differentiation|downregulation of leucocyte differentiation pr 2013-05-02T17:32:47Z biological_process owl:Class GO:0102925 biolink:NamedThing solanine UDP-galactose galactosyltransferase activity Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP. got7fsn_ti MetaCyc:RXN-8875 molecular_function owl:Class GO:0005277 biolink:NamedThing acetylcholine transmembrane transporter activity Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. got7fsn_ti Reactome:R-HSA-264615 molecular_function owl:Class GO:0005326 biolink:NamedThing neurotransmitter transmembrane transporter activity Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. got7fsn_ti neurotransmitter transmembrane transporter activity|neurotransmitter transporter activity Reactome:R-HSA-374919|Reactome:R-HSA-374896 molecular_function owl:Class GO:0010498 biolink:NamedThing proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. got7fsn_ti proteasome-mediated protein catabolic process|proteasome-mediated protein catabolism biological_process owl:Class GO:0051603 biolink:NamedThing proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. got7fsn_ti peptidolysis involved in cellular protein catabolism|peptidolysis during cellular protein catabolic process|proteolysis during cellular protein catabolism|peptidolysis during cellular protein catabolism|proteolysis during cellular protein catabolic process|peptidolysis involved in cellular protein catabolic process biological_process owl:Class GO:0043100 biolink:NamedThing pyrimidine nucleobase salvage Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis. got7fsn_ti pyrimidine base salvage biological_process owl:Class GO:0008655 biolink:NamedThing pyrimidine-containing compound salvage Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. got7fsn_ti pyrimidine salvage biological_process owl:Class GO:0047533 biolink:NamedThing 2,5-dioxovalerate dehydrogenase (NADP+) activity Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+. got7fsn_ti 2-oxoglutarate semialdehyde dehydrogenase activity|alpha-ketoglutaric semialdehyde dehydrogenase activity|2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity EC:1.2.1.26|MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN|RHEA:11296 molecular_function owl:Class GO:0046176 biolink:NamedThing aldonic acid catabolic process The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. got7fsn_ti aldonic acid breakdown|aldonic acid catabolism|aldonic acid degradation biological_process owl:Class GO:0044275 biolink:NamedThing cellular carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. got7fsn_ti cellular carbohydrate degradation|cellular carbohydrate breakdown|cellular carbohydrate catabolism biological_process owl:Class GO:0047750 biolink:NamedThing cholestenol delta-isomerase activity Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. got7fsn_ti cholestenol D-isomerase activity|delta7-cholestenol delta7-delta8-isomerase activity RHEA:15281|EC:5.3.3.5|MetaCyc:RXN66-25 molecular_function owl:Class GO:0061274 biolink:NamedThing mesonephric distal tubule development The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule. got7fsn_ti dph 2010-09-02T12:16:25Z biological_process owl:Class GO:0072017 biolink:NamedThing distal tubule development The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. got7fsn_ti mah 2010-01-25T02:34:19Z biological_process owl:Class GO:0005901 biolink:NamedThing caveola A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. got7fsn_ti caveolae|caveolar membrane GO:0016599 Wikipedia:Caveolae cellular_component owl:Class GO:0045121 biolink:NamedThing membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. got7fsn_ti GEM domain|glycolipid-enriched membrane domain|lipid raft Wikipedia:Lipid_raft cellular_component owl:Class GO:0043622 biolink:NamedThing cortical microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell. got7fsn_ti cortical microtubule organization and biogenesis|cortical microtubule cytoskeleton organization|cortical microtubule organisation biological_process owl:Class GO:0072678 biolink:NamedThing T cell migration The movement of a T cell within or between different tissues and organs of the body. got7fsn_ti T-cell migration|T lymphocyte migration|T-lymphocyte migration mah 2011-02-22T03:40:40Z biological_process owl:Class GO:0097201 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter in response to stress Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti pr 2011-12-14T09:16:22Z biological_process owl:Class GO:0043618 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to stress Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti biological_process owl:Class GO:0061433 biolink:NamedThing cellular response to caloric restriction Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake. got7fsn_ti dph 2012-02-09T09:03:15Z biological_process owl:Class GO:0061195 biolink:NamedThing taste bud formation The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors. got7fsn_ti dph 2010-07-27T12:22:26Z biological_process owl:Class GO:0160004 biolink:NamedThing poly-ADP-D-ribose modification-dependent protein binding Binding to a protein upon poly-ADP-ribosylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require a poly-ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. rl 2021-07-12T23:36:00Z molecular_function owl:Class GO:0160002 biolink:NamedThing ADP-D-ribose modification-dependent protein binding Binding to a protein upon ADP-ribosylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require a ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. rl 2021-07-12T23:31:53Z molecular_function owl:Class GO:0008332 biolink:NamedThing low voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. got7fsn_ti low voltage-dependent calcium channel activity|T-type calcium channel|low voltage gated calcium channel activity molecular_function owl:Class GO:0005245 biolink:NamedThing voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti dihydropyridine-sensitive calcium channel activity|voltage gated calcium channel activity|depolarization-activated calcium channel|voltage-gated calcium ion channel activity|depolarization-activated voltage-gated calcium channel activity|depolarization-activated voltage-gated calcium channel|voltage-dependent calcium channel activity|voltage-sensitive calcium channel|depolarization-activated voltage gated calcium channel activity GO:0010173|GO:0015270 Reactome:R-HSA-5577213|Reactome:R-HSA-265645|Reactome:R-HSA-9701055|Reactome:R-HSA-9701141 molecular_function owl:Class GO:0000285 biolink:NamedThing 1-phosphatidylinositol-3-phosphate 5-kinase activity Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). got7fsn_ti ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity|phosphatidylinositol-3-phosphate 5-kinase activity|phosphatidylinositol 3-phosphate 5-kinase activity|type III PIP kinase activity Reactome:R-HSA-1676134|Reactome:R-HSA-1676168|MetaCyc:2.7.1.150-RXN|Reactome:R-HSA-1675921|KEGG_REACTION:R05802|Reactome:R-HSA-1675910|RHEA:13609|EC:2.7.1.150 molecular_function owl:Class GO:0016307 biolink:NamedThing phosphatidylinositol phosphate kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. got7fsn_ti phosphatidylinositol monophosphate kinase activity molecular_function owl:Class GO:0008269 biolink:NamedThing JAK pathway signal transduction adaptor activity The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way. got7fsn_ti molecular_function owl:Class GO:0035591 biolink:NamedThing signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. got7fsn_ti signaling scaffold activity|signalling adaptor activity https://github.com/geneontology/go-ontology/issues/19050 A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins (PMID:19104498). bf 2010-11-05T11:22:01Z molecular_function owl:Class GO:0061359 biolink:NamedThing regulation of Wnt signaling pathway by Wnt protein secretion Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell. got7fsn_ti regulation of Wnt receptor signalling pathway by Wnt protein secretion|regulation of Wnt receptor signaling pathway by Wnt protein secretion|regulation of Wnt-activated signaling pathway by Wnt protein secretion dph 2010-10-08T01:18:02Z biological_process owl:Class GO:0030111 biolink:NamedThing regulation of Wnt signaling pathway Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. got7fsn_ti regulation of frizzled signalling pathway|regulation of Wnt-activated signaling pathway|regulation of Wnt receptor signaling pathway|regulation of frizzled signaling pathway|regulation of Wnt receptor signalling pathway GO:0008590 biological_process owl:Class GO:1990464 biolink:NamedThing D-2-hydroxyacid dehydrogenase (quinone) activity Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol. got7fsn_ti D-lactate dehydrogenase activity|(R)-2-hydroxy acid dehydrogenase activity|(R)-2-hydroxyacid:quinone oxidoreductase activity|D-lactate:quinone oxidoreductase activity|(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity|D-lactate dehydrogenase (quinone) activity (R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors. pr 2014-08-22T10:13:42Z molecular_function owl:Class GO:0016901 biolink:NamedThing oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. got7fsn_ti EC:1.1.5.- molecular_function owl:Class GO:0008938 biolink:NamedThing nicotinate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine. got7fsn_ti furanocoumarin 8-O-methyltransferase activity|S-adenosyl-L-methionine:nicotinate N-methyltransferase activity EC:2.1.1.7|MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN|RHEA:20241|KEGG_REACTION:R01721 molecular_function owl:Class GO:0070499 biolink:NamedThing exosporium assembly A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore. got7fsn_ti exosporium formation biological_process owl:Class GO:0045229 biolink:NamedThing external encapsulating structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. got7fsn_ti external encapsulating structure organisation|external encapsulating structure organization and biogenesis biological_process owl:Class GO:0033438 biolink:NamedThing ACC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an ACC codon. got7fsn_ti threonine tRNA Note that in the standard genetic code, ACC codes for threonine. molecular_function owl:Class GO:0030142 biolink:NamedThing COPI-coated Golgi to ER transport vesicle A vesicle that mediates transport from the Golgi to the endoplasmic reticulum. got7fsn_ti Golgi to endoplasmic reticulum transport vesicle|Golgi-ER transport vesicle|Golgi-endoplasmic reticulum transport vesicle|Golgi to ER constitutive secretory pathway transport vesicle|retrograde transport vesicle cellular_component owl:Class GO:0030137 biolink:NamedThing COPI-coated vesicle A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. got7fsn_ti coatomer cellular_component owl:Class GO:0015935 biolink:NamedThing small ribosomal subunit The smaller of the two subunits of a ribosome. got7fsn_ti ribosomal small subunit cellular_component owl:Class GO:0044391 biolink:NamedThing ribosomal subunit Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. got7fsn_ti jl 2011-12-15T04:47:59Z cellular_component owl:Class GO:0071152 biolink:NamedThing G-protein alpha(q)-synembrin complex A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein. got7fsn_ti Ric-8A G(q) alpha subunit complex mah 2009-11-16T04:48:05Z cellular_component owl:Class GO:0008737 biolink:NamedThing L-fuculokinase activity Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+). got7fsn_ti L-fuculokinase (phosphorylating)|ATP:L-fuculose 1-phosphotransferase activity|L-fuculose kinase activity MetaCyc:FUCULOKIN-RXN|KEGG_REACTION:R03241|EC:2.7.1.51|RHEA:12376 molecular_function owl:Class GO:0019200 biolink:NamedThing carbohydrate kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. got7fsn_ti Reactome:R-HSA-8931653 molecular_function owl:Class GO:0044533 biolink:NamedThing positive regulation of apoptotic process in other organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism. got7fsn_ti jl 2012-03-21T11:25:24Z biological_process owl:Class GO:0044532 biolink:NamedThing modulation of apoptotic process in other organism A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism. got7fsn_ti regulation of apoptotic process in other organism jl 2012-03-21T11:17:18Z biological_process owl:Class GO:0043829 biolink:NamedThing tRNA-specific adenosine-37 deaminase activity Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule. got7fsn_ti TAD1|tRNA-specific adenosine deaminase 1|tRNA(Ala)-A37 deaminase activity molecular_function owl:Class GO:0008251 biolink:NamedThing tRNA-specific adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule. got7fsn_ti tRNA-adenosine deaminase activity Reactome:R-HSA-6782336|Reactome:R-HSA-6782311 molecular_function owl:Class GO:0040025 biolink:NamedThing vulval development The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. got7fsn_ti biological_process owl:Class GO:0048569 biolink:NamedThing post-embryonic animal organ development Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti post-embryonic animal organogenesis biological_process owl:Class GO:0003041 biolink:NamedThing excitation of vasomotor center by carotid body chemoreceptor signaling The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure. got7fsn_ti excitation of vasomotor center by carotid body chemoreceptor signalling biological_process owl:Class GO:0002008 biolink:NamedThing excitation of vasomotor center by chemoreceptor signaling The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure. got7fsn_ti excitation of vasomotor center by chemoreceptor signalling biological_process owl:Class GO:0005185 biolink:NamedThing neurohypophyseal hormone activity The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin. got7fsn_ti neurohypophysial hormone activity molecular_function owl:Class GO:0005184 biolink:NamedThing neuropeptide hormone activity The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. got7fsn_ti neurohormone Wikipedia:Neurohormone molecular_function owl:Class GO:0072681 biolink:NamedThing fibronectin-dependent thymocyte migration The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix. got7fsn_ti fibronectin-dependent immature T cell migration|fibronectin-dependent immature T-lymphocyte migration|fibronectin-dependent immature T lymphocyte migration|fibronectin-dependent immature T-cell migration|fibronectin-dependent thymic lymphocyte migration mah 2011-02-22T03:53:06Z biological_process owl:Class GO:0072680 biolink:NamedThing extracellular matrix-dependent thymocyte migration The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on extracellular matrix components including fibronectin, collagen and laminin. got7fsn_ti extracellular matrix-dependent thymic lymphocyte migration|extracellular matrix-dependent immature T-cell migration|extracellular matrix-dependent immature T-lymphocyte migration|extracellular matrix-dependent immature T lymphocyte migration|extracellular matrix-dependent immature T cell migration mah 2011-02-22T03:49:57Z biological_process owl:Class GO:0047312 biolink:NamedThing L-phenylalanine:pyruvate aminotransferase activity Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine. got7fsn_ti phenylalanine(histidine):pyruvate aminotransferase activity|L-phenylalanine:pyruvate transaminase activity|phenylalanine (histidine) aminotransferase activity|histidine aminotransferase activity|L-phenylalanine(L-histidine):pyruvate aminotransferase activity|phenylalanine(histidine) transaminase activity|L-histidine:pyruvate aminotransferase activity|phenylalanine(histidine) aminotransferase activity|histidine:pyruvate aminotransferase activity Reactome:R-HSA-893593|RHEA:13053|KEGG_REACTION:R00692|EC:2.6.1.58|MetaCyc:2.6.1.58-RXN molecular_function owl:Class GO:0070546 biolink:NamedThing L-phenylalanine aminotransferase activity Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid. got7fsn_ti molecular_function owl:Class GO:0051882 biolink:NamedThing mitochondrial depolarization The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level. got7fsn_ti mitochondrion depolarization|mitochondria depolarization|mitochondrial membrane depolarization|mitochondrial depolarisation biological_process owl:Class GO:2000384 biolink:NamedThing negative regulation of ectoderm development Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. got7fsn_ti vk 2011-02-15T03:17:27Z biological_process owl:Class GO:0030741 biolink:NamedThing inositol 1-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+). got7fsn_ti myo-inositol 3-O-methyltransferase activity|inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)|S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity|inositol D-1-methyltransferase activity|S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity|inositol 3-O-methyltransferase activity|S-adenosylmethionine:myo-inositol 3-methyltransferase activity MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN|RHEA:17565|KEGG_REACTION:R01188|EC:2.1.1.40 molecular_function owl:Class GO:0045901 biolink:NamedThing positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. got7fsn_ti up-regulation of translational elongation|activation of translational elongation|up regulation of translational elongation|stimulation of translational elongation|upregulation of translational elongation biological_process owl:Class GO:0045727 biolink:NamedThing positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. got7fsn_ti positive regulation of protein biosynthesis|positive regulation of protein anabolism|positive regulation of protein formation|positive regulation of protein synthesis|activation of protein biosynthetic process|positive regulation of protein biosynthetic process|upregulation of protein biosynthetic process|up-regulation of protein biosynthetic process|up regulation of protein biosynthetic process|stimulation of protein biosynthetic process GO:0045946 biological_process owl:Class GO:0044407 biolink:NamedThing single-species biofilm formation in or on host organism A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class GO:0044010 biolink:NamedThing single-species biofilm formation A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. got7fsn_ti bfp-dependent aggregation|auto-aggregation|tfp-dependent aggregation|type IV pili-dependent aggregation|bundle-forming pili-dependent aggregation|bundle-forming fimbriae-dependent aggregation https://github.com/geneontology/go-ontology/issues/18814 GO:0052000 biological_process owl:Class GO:0085014 biolink:NamedThing dormancy entry of symbiont in host Entry into a dormant state of the symbiont within the host organism. got7fsn_ti jl 2010-05-19T02:33:26Z biological_process owl:Class GO:0022611 biolink:NamedThing dormancy process A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated. got7fsn_ti multicellular organism dormancy process|spore dormancy process In plants and animals, dormancy may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. In plants, dormancy may involve the formation of dormant buds, and may be preceded by the senescence of plant parts such as leaves in woody plants or most of the shoot system in herbaceous perennials. The exit from dormancy in vascular plants is marked by resumed growth of buds and/or growth of vascular cambium. biological_process owl:Class GO:0002274 biolink:NamedThing myeloid leukocyte activation A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti myeloid leucocyte activation biological_process owl:Class GO:0045321 biolink:NamedThing leukocyte activation A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. got7fsn_ti leucocyte activation|immune cell activation Wikipedia:Immunologic_activation biological_process owl:Class GO:0060044 biolink:NamedThing negative regulation of cardiac muscle cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. got7fsn_ti negative regulation of heart muscle cell proliferation biological_process owl:Class GO:0097533 biolink:NamedThing cellular stress response to acid chemical Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. got7fsn_ti cellular response to acid stress|cellular stress response to acid pr 2013-11-12T13:07:12Z biological_process owl:Class GO:0097532 biolink:NamedThing stress response to acid chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. got7fsn_ti response to acid stress|stress response to acid pr 2013-11-12T13:04:15Z biological_process owl:Class GO:0034599 biolink:NamedThing cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. got7fsn_ti adaptive response to oxidative stress biological_process owl:Class GO:0004758 biolink:NamedThing serine C-palmitoyltransferase activity Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA. got7fsn_ti 3-oxosphinganine synthetase activity|SPT|serine palmitoyltransferase|acyl-CoA:serine C-2 acyltransferase decarboxylating|palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity KEGG_REACTION:R01281|EC:2.3.1.50|Reactome:R-HSA-428127|RHEA:14761|MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN molecular_function owl:Class GO:0016454 biolink:NamedThing C-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class GO:0035244 biolink:NamedThing peptidyl-arginine C-methyltransferase activity Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. got7fsn_ti molecular_function owl:Class GO:0008276 biolink:NamedThing protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein. got7fsn_ti Reactome:R-HSA-9632182 molecular_function owl:Class GO:0102620 biolink:NamedThing 3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O. got7fsn_ti MetaCyc:RXN-15495 molecular_function owl:Class GO:0102867 biolink:NamedThing molybdenum cofactor sulfurtransferase activity Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O. got7fsn_ti MetaCyc:RXN-8351|RHEA:42636|EC:2.8.1.9 molecular_function owl:Class GO:0046692 biolink:NamedThing sperm competition Any process that contributes to the success of sperm fertilization in multiply-mated females. got7fsn_ti Wikipedia:Sperm_competition biological_process owl:Class GO:0048609 biolink:NamedThing multicellular organismal reproductive process The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. got7fsn_ti reproductive process in a multicellular organism|organismal reproductive process biological_process owl:Class GO:0120077 biolink:NamedThing angiogenic sprout fusion The connection of an angiogenic sprout to another vessel or sprout during the formation of vascular networks by sprouting angiogenesis. got7fsn_ti blood vessel anastomosis|angiogenic sprout fusion https://github.com/geneontology/go-ontology/issues/13690 krc 2017-06-27T21:16:55Z biological_process owl:Class GO:0051650 biolink:NamedThing establishment of vesicle localization The directed movement of a vesicle to a specific location. got7fsn_ti establishment of vesicle localisation biological_process owl:Class GO:1990167 biolink:NamedThing protein K27-linked deubiquitination A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein. got7fsn_ti sp 2013-08-14T11:15:24Z biological_process owl:Class GO:0016579 biolink:NamedThing protein deubiquitination The removal of one or more ubiquitin groups from a protein. got7fsn_ti deubiquitination|protein deubiquitylation|protein deubiquitinylation GO:0006514 biological_process owl:Class GO:1990960 biolink:NamedThing basophil homeostasis The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti basophilic leucocyte homeostasis sl 2016-06-06T22:38:22Z biological_process owl:Class GO:0002262 biolink:NamedThing myeloid cell homeostasis The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti biological_process owl:Class GO:0006614 biolink:NamedThing SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. got7fsn_ti ER translocation|SRP-dependent cotranslational protein-membrane targeting|SRP-dependent cotranslational membrane targeting biological_process owl:Class GO:0046352 biolink:NamedThing disaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units. got7fsn_ti disaccharide breakdown|disaccharide catabolism|disaccharide degradation biological_process owl:Class GO:0015454 biolink:NamedThing light-driven active transmembrane transporter activity Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. got7fsn_ti light-driven pumps|Light absorption-driven transporters TC:3.E molecular_function owl:Class GO:0015399 biolink:NamedThing primary active transmembrane transporter activity Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources. got7fsn_ti primary active transporter TC:3 molecular_function owl:Class GO:0032421 biolink:NamedThing stereocilium bundle A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. got7fsn_ti stereocilia bundle cellular_component owl:Class GO:0098862 biolink:NamedThing cluster of actin-based cell projections A cell part consisting of multiple, closely packed actin-based cell projections. got7fsn_ti cellular_component owl:Class GO:0090545 biolink:NamedThing CHD-type complex A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. got7fsn_ti tb 2013-02-15T12:11:57Z cellular_component owl:Class GO:0070603 biolink:NamedThing SWI/SNF superfamily-type complex A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. got7fsn_ti SWI-SNF-type complex|SWI-SNF global transcription activator complex|BAF-type complex|SWI/SNF-type complex|SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex mah 2009-04-29T12:55:46Z GO:0090544 cellular_component owl:Class GO:0019517 biolink:NamedThing L-threonine catabolic process to D-lactate The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate. got7fsn_ti L-threonine breakdown to D-lactate|L-threonine catabolic process to methylglyoxal|L-threonine degradation to D-lactate|L-threonine catabolic process to pyruvate|L-threonine catabolic process to (R)-lactate|L-threonine catabolism to D-lactate|threonine catabolic process to D-lactate MetaCyc:THRDLCTCAT-PWY biological_process owl:Class GO:0006567 biolink:NamedThing threonine catabolic process The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. got7fsn_ti threonine catabolism|threonine degradation|threonine breakdown MetaCyc:THREOCAT-PWY|UM-BBD_pathwayID:met biological_process owl:Class GO:0046994 biolink:NamedThing oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound. got7fsn_ti EC:1.12.5.- molecular_function owl:Class GO:0050313 biolink:NamedThing sulfur dioxygenase activity Catalysis of the reaction: sulfur + O2 + H2O = sulfite. got7fsn_ti sulphur dioxygenase activity|sulfur:oxygen oxidoreductase activity|S-sulfanylglutathione:oxygen oxidoreductase activity|sulfur oxygenase activity RHEA:12981|Reactome:R-HSA-1614605|MetaCyc:FESGSHTHIO-RXN|EC:1.13.11.18 molecular_function owl:Class GO:0043529 biolink:NamedThing GET complex An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20244 cellular_component owl:Class GO:0102509 biolink:NamedThing cyanidin 3,5-diglucoside glucosidase activity Catalysis of the reaction: cyanin betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose. got7fsn_ti MetaCyc:RXN-14436 molecular_function owl:Class GO:0006949 biolink:NamedThing syncytium formation The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. got7fsn_ti biological_process owl:Class GO:0018133 biolink:NamedThing peptide cross-linking via L-cysteine oxazolinecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue. got7fsn_ti RESID:AA0239 biological_process owl:Class GO:0018157 biolink:NamedThing peptide cross-linking via an oxazole or thiazole The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti peptide heterocycle biosynthesis|peptide heterocycle synthesis|peptide heterocycle biosynthetic process|peptide heterocycle formation biological_process owl:Class GO:0009562 biolink:NamedThing embryo sac nuclear migration The directed movement of an embryo sac nucleus to the pole or center of the cell. got7fsn_ti female gametophyte nucleus migration|megagametophyte nucleus migration|embryo sac nucleus migration|megagametophyte nuclear migration|female gametophyte nuclear migration biological_process owl:Class GO:0007097 biolink:NamedThing nuclear migration The directed movement of the nucleus to a specific location within a cell. got7fsn_ti establishment of localization of nucleus|establishment of nucleus localization|nuclear positioning|establishment of cell nucleus localization|positioning of nucleus|establishment of nucleus localisation|establishment of position of nucleus|nuclear movement|nucleus positioning|nucleus migration GO:0040023 biological_process owl:Class GO:0052035 biolink:NamedThing positive regulation by symbiont of host inflammatory response Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti stimulation by symbiont of host inflammatory response|up regulation by symbiont of host inflammatory response|up-regulation by symbiont of host inflammatory response|positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction|upregulation by symbiont of host inflammatory response|activation by symbiont of host inflammatory response GO:0052259 biological_process owl:Class GO:0052032 biolink:NamedThing modulation by symbiont of host inflammatory response Any process in which a symbiont modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of inflammatory response of other organism involved in symbiotic interaction GO:0052256 biological_process owl:Class GO:0070021 biolink:NamedThing transforming growth factor beta ligand-receptor complex A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand. got7fsn_ti TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex|TGFbeta2 ligand-receptor complex|TGFb ligand-receptor complex|TGF-beta ligand-receptor complex|TGFbeta1-beta2 ligand-receptor complex|TGF-beta1-type II receptor-type I receptor complex|TGFbeta ligand-receptor complex|TGF-beta1-beta2 ligand-receptor complex|TGFbeta1 ligand-receptor complex|transforming growth factor beta1-type II receptor-type I receptor complex|TGF-beta2 ligand-receptor complex|TGF-beta 1:type II receptor:type I receptor complex|TGF-beta1 ligand-receptor complex cellular_component owl:Class GO:0044271 biolink:NamedThing cellular nitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. got7fsn_ti nitrogen compound biosynthesis|nitrogen compound synthesis|nitrogen compound anabolism|nitrogen compound formation biological_process owl:Class GO:0034528 biolink:NamedThing 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate. got7fsn_ti UM-BBD_reactionID:r0791|EC:5.3.99.- molecular_function owl:Class GO:0008925 biolink:NamedThing maltose O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose. got7fsn_ti acetyl-CoA:maltose O-acetyltransferase activity|maltose transacetylase activity EC:2.3.1.79|RHEA:10456|MetaCyc:MALTACETYLTRAN-RXN molecular_function owl:Class GO:0004314 biolink:NamedThing [acyl-carrier-protein] S-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. got7fsn_ti malonyl-CoA:ACP transacylase activity|acyl-carrier-protein S-malonyltransferase activity|malonyl-CoA-acyl carrier protein transacylase activity|MCAT activity|malonyl transacylase activity|[acyl-carrier protein] S-malonyltransferase activity|malonyl transferase activity|malonyl-CoA:acyl carrier protein transacylase activity|FabD|acyl carrier proteinmalonyltransferase activity|malonyl-CoA:AcpM transacylase activity|malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity|malonyl coenzyme A-acyl carrier protein transacylase activity|MAT|acyl carrier protein malonyltransferase activity|ACP S-malonyltransferase activity MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN|Reactome:R-HSA-8933547|EC:2.3.1.39 molecular_function owl:Class GO:0004312 biolink:NamedThing fatty acid synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. got7fsn_ti acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)|fatty-acid synthase activity RHEA:14993|EC:2.3.1.85|MetaCyc:FATTY-ACID-SYNTHASE-RXN|Reactome:R-HSA-75872 molecular_function owl:Class GO:0050055 biolink:NamedThing limonin-D-ring-lactonase activity Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate. got7fsn_ti limonin lactone hydrolase activity|limonin-D-ring-lactone hydrolase activity|limonoate-D-ring-lactone lactonohydrolase activity MetaCyc:LIMONIN-D-RING-LACTONASE-RXN|EC:3.1.1.36|RHEA:10896 molecular_function owl:Class GO:0052083 biolink:NamedThing suppression by symbiont of host cell-mediated immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti downregulation by symbiont of host cell-mediated immune response|down regulation by symbiont of host cell-mediated immune response|negative regulation by organism of host cell-based immune response|negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction|inhibition by symbiont of host cell-mediated immune response|down-regulation by symbiont of host cell-mediated immune response GO:0052278 biological_process owl:Class GO:0030259 biolink:NamedThing lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. got7fsn_ti biological_process owl:Class GO:0043839 biolink:NamedThing lipid A phosphate methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A. got7fsn_ti lipid A 1-phosphomethyltransferase activity|lipid A phosphomethyltransferase activity|LmtA|lipid A methyltransferase molecular_function owl:Class GO:0140383 biolink:NamedThing 4-hydroxytryptamine kinase activity Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+). got7fsn_ti pg 2019-11-20T10:30:05Z RHEA:55564|EC:2.7.1.222 molecular_function owl:Class GO:0018594 biolink:NamedThing tert-butanol 2-monooxygenase activity Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol. got7fsn_ti tert-butyl alcohol 2-monooxygenase activity molecular_function owl:Class GO:0016671 biolink:NamedThing oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. got7fsn_ti oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor EC:1.8.4.- molecular_function owl:Class GO:0031409 biolink:NamedThing pigment binding Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin. got7fsn_ti molecular_function owl:Class GO:0030447 biolink:NamedThing filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. got7fsn_ti biological_process owl:Class GO:0035853 biolink:NamedThing chromosome passenger complex localization to spindle midzone A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. got7fsn_ti chromosome passenger complex localisation to spindle midzone|chromosomal passenger complex localization to spindle midzone|CPC complex localization to spindle midzone|chromosome passenger complex localization to spindle equator|chromosome passenger complex localization to central spindle|CPC localization to spindle midzone bf 2011-05-13T01:19:51Z biological_process owl:Class GO:0034629 biolink:NamedThing cellular protein-containing complex localization A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell. got7fsn_ti cellular protein complex localisation|establishment and maintenance of cellular protein complex localization|cellular protein complex localization biological_process owl:Class GO:0047211 biolink:NamedThing alpha-1,4-glucan-protein synthase (ADP-forming) activity Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP. got7fsn_ti ADPglucose:protein glucosyltransferase activity|ADP-glucose:protein 4-alpha-D-glucosyltransferase activity|adenosine diphosphoglucose-protein glucosyltransferase activity|1,4alpha-glucan-protein synthase (ADP-forming) activity|ADPglucose:protein 4-alpha-D-glucosyltransferase activity MetaCyc:2.4.1.113-RXN|EC:2.4.1.113 molecular_function owl:Class GO:0060136 biolink:NamedThing embryonic process involved in female pregnancy A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. got7fsn_ti biological_process owl:Class GO:0102482 biolink:NamedThing 5-deoxy-D-glucuronate isomerase activity Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate. got7fsn_ti EC:5.3.1.30|RHEA:25840|MetaCyc:RXN-14150 molecular_function owl:Class GO:0051446 biolink:NamedThing positive regulation of meiotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. got7fsn_ti upregulation of progression through meiotic cell cycle|positive regulation of meiotic cell cycle progression|up regulation of progression through meiotic cell cycle|stimulation of progression through meiotic cell cycle|up-regulation of progression through meiotic cell cycle|positive regulation of progression through meiotic cell cycle|activation of progression through meiotic cell cycle biological_process owl:Class GO:0051445 biolink:NamedThing regulation of meiotic cell cycle Any process that modulates the rate or extent of progression through the meiotic cell cycle. got7fsn_ti modulation of meiotic cell cycle progression|regulation of progression through meiotic cell cycle|meiotic cell cycle modulation|meiotic cell cycle regulator|meiotic cell cycle regulation|regulation of meiotic cell cycle progression biological_process owl:Class GO:0051328 biolink:NamedThing meiotic interphase The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA. got7fsn_ti interphase of meiotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class GO:0051325 biolink:NamedThing interphase The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs. got7fsn_ti karyostasis|resting phase Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Interphase biological_process owl:Class GO:0006022 biolink:NamedThing aminoglycan metabolic process The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. got7fsn_ti aminoglycan metabolism biological_process owl:Class GO:0043170 biolink:NamedThing macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti multicellular organismal macromolecule metabolic process|macromolecule metabolism|biopolymer metabolic process|organismal macromolecule metabolism GO:0043283|GO:0044259 biological_process owl:Class GO:0090384 biolink:NamedThing phagosome-lysosome docking The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere. got7fsn_ti lysosome recruitment to phagosome tb 2010-10-27T10:24:28Z biological_process owl:Class GO:0048278 biolink:NamedThing vesicle docking The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. got7fsn_ti vesicle to membrane docking biological_process owl:Class GO:0001983 biolink:NamedThing baroreceptor response to increased systemic arterial blood pressure The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels. got7fsn_ti biological_process owl:Class GO:0001978 biolink:NamedThing regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control. got7fsn_ti baroreceptor feedback control of blood pressure|baroreceptor pressure buffer system|carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure biological_process owl:Class GO:0031017 biolink:NamedThing exocrine pancreas development The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. got7fsn_ti biological_process owl:Class GO:0042263 biolink:NamedThing neuropeptide F receptor activity Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa. got7fsn_ti NPF receptor activity Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related. molecular_function owl:Class GO:0008188 biolink:NamedThing neuropeptide receptor activity Combining with a neuropeptide to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class GO:0102654 biolink:NamedThing 1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-1725|RHEA:46764|EC:1.14.19.43 molecular_function owl:Class GO:0033914 biolink:NamedThing xylan 1,3-beta-xylosidase activity Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans. got7fsn_ti 1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity|1,3-beta-D-xylan xylohydrolase activity|exo-1,3-beta-xylosidase activity|beta-1,3'-xylanase activity|exo-beta-1,3'-xylanase activity MetaCyc:3.2.1.72-RXN|EC:3.2.1.72 molecular_function owl:Class GO:0097599 biolink:NamedThing xylanase activity Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues. got7fsn_ti xylosidase activity pr 2014-05-06T13:46:48Z molecular_function owl:Class GO:0102362 biolink:NamedThing esculetin 3-O-glucosyltransferase activity Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 3-O-beta-D-glucosyl-esculetin + UDP + H+. got7fsn_ti MetaCyc:RXN-13472 molecular_function owl:Class GO:0021970 biolink:NamedThing corticospinal neuron axon guidance through the basilar pons The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues. got7fsn_ti corticospinal neuron axon pathfinding through the basilar pons biological_process owl:Class GO:0001863 biolink:NamedThing collectin receptor activity Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). molecular_function owl:Class GO:0001847 biolink:NamedThing opsonin receptor activity Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class GO:0046739 biolink:NamedThing transport of virus in multicellular host The transport of a virus between cells in a multicellular organism. The cells can be adjacent or spatially separated (e.g. in different tissues or organs). got7fsn_ti spread of virus in multicellular host|spread of virus within multicellular host|viral spread within multicellular host biological_process owl:Class GO:0044000 biolink:NamedThing movement in host The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti movement of symbiont within host|movement of symbiont in host|symbiont movement in host|symbiont movement within host|movement within host biological_process owl:Class GO:0072014 biolink:NamedThing proximal tubule development The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology. got7fsn_ti mah 2010-01-25T02:33:46Z biological_process owl:Class GO:0072080 biolink:NamedThing nephron tubule development The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. got7fsn_ti mah 2010-02-01T02:32:12Z biological_process owl:Class SO:0000673 biolink:NamedThing got7fsn_ti owl:Class CHEBI:33697 biolink:NamedThing got7fsn_ti owl:Class GO:0075119 biolink:NamedThing induction by symbiont of host G protein-coupled receptor signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit|positive regulation by symbiont of host G-protein coupled receptor protein signal transduction|positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit|positive regulation by symbiont of host G protein-coupled receptor signal transduction|positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by symbiont of host G protein-coupled receptor signal transduction ; GO:0075088". GO:0075128|GO:0075125|GO:0075122 biological_process owl:Class GO:0021716 biolink:NamedThing inferior olivary nucleus structural organization The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. got7fsn_ti inferior olivary nucleus structural organisation|inferior olive structural organization biological_process owl:Class GO:0000707 biolink:NamedThing meiotic DNA recombinase assembly During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA. got7fsn_ti biological_process owl:Class GO:0061982 biolink:NamedThing meiosis I cell cycle process A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs. got7fsn_ti first meiotic cell division dph 2018-02-14T22:27:20Z biological_process owl:Class GO:0042043 biolink:NamedThing neurexin family protein binding Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. got7fsn_ti neuroligin GO:0019963 molecular_function owl:Class GO:0005102 biolink:NamedThing signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. got7fsn_ti receptor binding|receptor ligand|receptor-associated protein activity Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. Wikipedia:Ligand_(biochemistry) molecular_function owl:Class GO:0103081 biolink:NamedThing methylthiopropylmalate dehydrogenase activity Catalysis of the reaction: 3-(3'-methylthio)propylmalate <=> H+ + 2-oxo-6-methylthiohexanoate + carbon dioxide. got7fsn_ti MetaCyc:RXNQT-4165 molecular_function owl:Class GO:0045296 biolink:NamedThing cadherin binding Binding to cadherin, a type I membrane protein involved in cell adhesion. got7fsn_ti molecular_function owl:Class GO:0050839 biolink:NamedThing cell adhesion molecule binding Binding to a cell adhesion molecule. got7fsn_ti adhesive extracellular matrix constituent|cell adhesion molecule activity|cell adhesion receptor activity|CAM binding molecular_function owl:Class GO:0048878 biolink:NamedThing chemical homeostasis Any biological process involved in the maintenance of an internal steady state of a chemical. got7fsn_ti biological_process owl:Class GO:0018366 biolink:NamedThing chiral amino acid racemization The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid. got7fsn_ti biological_process owl:Class GO:0006520 biolink:NamedThing cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. got7fsn_ti cellular amino acid metabolism|amino acid and derivative metabolism|cellular amino acid and derivative metabolic process|amino acid metabolic process GO:0006519 biological_process owl:Class GO:0036441 biolink:NamedThing 2-dehydropantolactone reductase activity Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. got7fsn_ti bf 2013-09-30T16:26:27Z RHEA:18981|KEGG_REACTION:R03155 molecular_function owl:Class GO:0019664 biolink:NamedThing mixed acid fermentation The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP. got7fsn_ti glucose catabolic process to mixed acids|glucose fermentation to mixed acids Wikipedia:Mixed_acid_fermentation biological_process owl:Class GO:0019660 biolink:NamedThing glycolytic fermentation Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. got7fsn_ti MetaCyc:Pyruvate-Degredation biological_process owl:Class GO:0140502 biolink:NamedThing effector-mediated suppression of host salicylic acid-mediated innate immune signalling A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signalling. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19848 pg 2020-08-11T06:16:36Z biological_process owl:Class GO:0071546 biolink:NamedThing pi-body A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes. got7fsn_ti intermitochondrial cement mah 2010-01-12T05:44:12Z cellular_component owl:Class GO:0043186 biolink:NamedThing P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. got7fsn_ti germline granule|nuage|polar granule GO:0018994 cellular_component owl:Class GO:0005009 biolink:NamedThing insulin-activated receptor activity Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti insulin receptor activity Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand insulin. For receptors that bind other extracellular ligands, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class GO:0004714 biolink:NamedThing transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. got7fsn_ti receptor protein tyrosine kinase activity|receptor protein-tyrosine kinase activity Reactome:R-HSA-8987096|Reactome:R-HSA-8950423|Reactome:R-HSA-8986985|Reactome:R-HSA-8987070|EC:2.7.10.1|Reactome:R-HSA-8987042|Reactome:R-HSA-8950340|Reactome:R-HSA-8983300|Reactome:R-HSA-8987084|Reactome:R-HSA-8987012|Reactome:R-HSA-8950757|Reactome:R-HSA-8983309|Reactome:R-HSA-8950591|Reactome:R-HSA-8987040|Reactome:R-HSA-74742|Reactome:R-HSA-169905|Reactome:R-HSA-8983424|Reactome:R-HSA-8853792|Reactome:R-HSA-8987150|Reactome:R-HSA-8986995|Reactome:R-HSA-8987255|Reactome:R-HSA-8982163|Reactome:R-HSA-8950364|Reactome:R-HSA-8950537|Reactome:R-HSA-74715|Reactome:R-HSA-8987202|Reactome:R-HSA-74711|Reactome:R-HSA-8986994|Reactome:R-HSA-8983371|Reactome:R-HSA-167019|Reactome:R-HSA-8950405|Reactome:R-HSA-8987179|Reactome:R-HSA-8987141|Reactome:R-HSA-177933|Reactome:R-HSA-8987129|Reactome:R-HSA-198295|Reactome:R-HSA-8852552|Reactome:R-HSA-8950354|Reactome:R-HSA-8950269|Reactome:R-HSA-167683|Reactome:R-HSA-6784324|Reactome:R-HSA-166544|Reactome:R-HSA-8950485|Reactome:R-HSA-8950453|MetaCyc:2.7.10.1-RXN molecular_function owl:Class GO:0038170 biolink:NamedThing somatostatin signaling pathway The series of molecular signals generated as a consequence of the peptide somatostatin (SST) binding to a somatostatin receptor (SSTR). The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti somatostatin signalling pathway|SRIF signaling pathway|somatostatin-mediated signaling pathway|somatostatin-activated somatostatin receptor signaling pathway|SST signaling pathway|somatotrophin release inhibiting factor signaling pathway bf 2012-06-12T10:33:21Z biological_process owl:Class GO:0098593 biolink:NamedThing goblet cell theca A cup shaped specialization of the cytoskeleton that forms a thin layer located just below the apical mass of mature mucin secretory granules in the cytoplasm of goblet cells of the intestinal epithelium. It consists of an orderly network of intermediate filaments and microtubules. Microtubules are arranged vertically, like barrel staves, along the inner aspect of the theta. Intermediate filaments form two networks: an inner, basketlike network and an outer series of circumferential bundles resembling the hoops of a barrel. got7fsn_ti dos 2014-03-11T14:52:33Z cellular_component owl:Class GO:0060036 biolink:NamedThing notochord cell vacuolation The assembly and arrangement of a vacuole within a cell of the notochord. got7fsn_ti biological_process owl:Class GO:0007033 biolink:NamedThing vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. got7fsn_ti vacuole biogenesis|vacuole organization and biogenesis|vacuole organisation|vacuolar assembly GO:0044086 biological_process owl:Class GO:0000460 biolink:NamedThing maturation of 5.8S rRNA Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. got7fsn_ti biological_process owl:Class GO:0006364 biolink:NamedThing rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. got7fsn_ti 35S primary transcript processing GO:0006365 biological_process owl:Class GO:0097329 biolink:NamedThing response to antimetabolite Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. got7fsn_ti pr 2012-06-12T10:52:01Z biological_process owl:Class GO:0034552 biolink:NamedThing respiratory chain complex II assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. got7fsn_ti biological_process owl:Class GO:0002421 biolink:NamedThing B cell antigen processing and presentation following pinocytosis B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis. got7fsn_ti B-cell antigen processing and presentation following pinocytosis|B-lymphocyte antigen processing and presentation following pinocytosis|B lymphocyte antigen processing and presentation following pinocytosis biological_process owl:Class GO:0035855 biolink:NamedThing megakaryocyte development The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. got7fsn_ti megakaryocyte cell development bf 2011-05-13T01:28:06Z biological_process owl:Class GO:0061515 biolink:NamedThing myeloid cell development The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. got7fsn_ti dph 2013-04-18T13:03:16Z biological_process owl:Class GO:0051778 biolink:NamedThing ent-7-alpha-hydroxykaurenoate oxidase activity Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). got7fsn_ti Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. MetaCyc:RXN1F-160|RHEA:22904 molecular_function owl:Class GO:0030144 biolink:NamedThing alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors. got7fsn_ti UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity|alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyltransferase V activity|UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity|GnTV activity|alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity|alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity EC:2.4.1.155|MetaCyc:2.4.1.155-RXN|Reactome:R-HSA-975916|Reactome:R-HSA-9696980|RHEA:16921 molecular_function owl:Class GO:0060955 biolink:NamedThing neural crest-derived cardiac glial cell fate commitment The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells. got7fsn_ti dph 2009-09-29T03:15:04Z biological_process owl:Class GO:0060953 biolink:NamedThing cardiac glial cell fate commitment The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells. got7fsn_ti dph 2009-09-29T03:11:23Z biological_process owl:Class GO:0019487 biolink:NamedThing anaerobic acetylene catabolic process The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen. got7fsn_ti anaerobic acetylene catabolism|anaerobic acetylene degradation|anaerobic ethyne catabolic process|anaerobic ethyne catabolism|anaerobic acetylene breakdown MetaCyc:P161-PWY biological_process owl:Class GO:0043454 biolink:NamedThing alkyne catabolic process The chemical reactions and pathways resulting in the breakdown of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2. got7fsn_ti alkyne breakdown|alkyne catabolism|alkyne degradation biological_process owl:Class GO:0060535 biolink:NamedThing trachea cartilage morphogenesis The process in which the anatomical structures of cartilage in the trachea are generated and organized. got7fsn_ti dph 2009-04-10T09:07:48Z biological_process owl:Class GO:0060536 biolink:NamedThing cartilage morphogenesis The process in which the anatomical structures of cartilage are generated and organized. got7fsn_ti dph 2009-04-10T09:13:27Z biological_process owl:Class GO:0071197 biolink:NamedThing Kv4.2-Kv4.3 channel complex A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3. got7fsn_ti mah 2009-11-23T05:00:33Z CORUM:609 cellular_component owl:Class GO:0008076 biolink:NamedThing voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. got7fsn_ti voltage-sensitive potassium channel complex|voltage gated potassium channel complex|voltage-dependent potassium channel complex NIF_Subcellular:sao371494298 cellular_component owl:Class GO:0010557 biolink:NamedThing positive regulation of macromolecule biosynthetic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biological_process owl:Class GO:0010556 biolink:NamedThing regulation of macromolecule biosynthetic process Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biological_process owl:Class GO:0062141 biolink:NamedThing nuclear exosome targeting complex A protein-containing complex that functions with the RNA exosome and contributes to the degradation of abberant transcripts. got7fsn_ti NEXT complex dph 2019-08-29T14:46:59Z cellular_component owl:Class GO:0097641 biolink:NamedThing alpha-ketoglutarate-dependent xanthine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate. got7fsn_ti alpha-ketoglutarate- and Fe(II)-dependent xanthine hydroxylase activity|alpha-ketoglutarate- and Fe(II)-dependent xanthine dioxygenase activity|2-oxoglutarate-dependent xanthine dioxygenase activity pr 2014-09-03T14:55:42Z RHEA:43120 molecular_function owl:Class GO:0006513 biolink:NamedThing protein monoubiquitination Addition of a single ubiquitin group to a protein. got7fsn_ti protein monoubiquitylation|protein monoubiquitinylation biological_process owl:Class GO:0016567 biolink:NamedThing protein ubiquitination The process in which one or more ubiquitin groups are added to a protein. got7fsn_ti protein ubiquitinylation|protein ubiquitylation biological_process owl:Class GO:0106310 biolink:NamedThing protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20114 Note that this term is to annotate proteins the specifically phosphorylate a serine residue on a protein. An example is human PIKFYVE (UniProt:Q9Y2I7). For dual specificity protein kinases, use 'protein serine/threonine kinase activity' ; GO:0004712. hjd 2020-09-22T20:01:17Z RHEA:17989 molecular_function owl:Class GO:0034772 biolink:NamedThing histone H4-K20 dimethylation The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone. got7fsn_ti histone lysine H4 K20 dimethylation|histone H4 K20 dimethylation biological_process owl:Class GO:0018027 biolink:NamedThing peptidyl-lysine dimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. got7fsn_ti RESID:AA0075 biological_process owl:Class GO:0070415 biolink:NamedThing trehalose metabolism in response to cold stress The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. got7fsn_ti trehalose metabolic process involved in response to cold stress biological_process owl:Class GO:0070413 biolink:NamedThing trehalose metabolism in response to stress The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress. got7fsn_ti trehalose metabolic process involved in response to stress biological_process owl:Class GO:0036094 biolink:NamedThing small molecule binding Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule. got7fsn_ti Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. bf 2012-01-17T04:20:34Z molecular_function owl:Class GO:0034656 biolink:NamedThing nucleobase-containing small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. got7fsn_ti nucleobase, nucleoside and nucleotide catabolism|nucleobase, nucleoside and nucleotide degradation|nucleobase, nucleoside and nucleotide breakdown biological_process owl:Class GO:0102521 biolink:NamedThing tRNA-4-demethylwyosine synthase activity Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe. got7fsn_ti EC:4.1.3.44|MetaCyc:RXN-14516|RHEA:36347 molecular_function owl:Class GO:0002346 biolink:NamedThing B cell positive selection Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor. got7fsn_ti B lymphocyte positive selection|B-lymphocyte positive selection|B-cell positive selection biological_process owl:Class GO:0002339 biolink:NamedThing B cell selection The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival. got7fsn_ti B-cell selection|B lymphocyte selection|B-lymphocyte selection biological_process owl:Class GO:0035220 biolink:NamedThing wing disc development Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura. got7fsn_ti biological_process owl:Class GO:0007444 biolink:NamedThing imaginal disc development The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.). got7fsn_ti biological_process owl:Class GO:0047495 biolink:NamedThing membrane-oligosaccharide glycerophosphotransferase activity Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another. got7fsn_ti periplasmic phosphoglycerotransferase activity|membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity|phosphoglycerol cyclase activity MetaCyc:2.7.8.21-RXN|EC:2.7.8.21 molecular_function owl:Class GO:0016035 biolink:NamedThing zeta DNA polymerase complex A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer. got7fsn_ti cellular_component owl:Class GO:0046912 biolink:NamedThing acyltransferase, acyl groups converted into alkyl on transfer Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. got7fsn_ti transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer https://github.com/geneontology/go-ontology/issues/20486 EC:2.3.3.- molecular_function owl:Class GO:0000266 biolink:NamedThing mitochondrial fission The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. got7fsn_ti mitochondrial proliferation|mitochondrial division biological_process owl:Class GO:0007005 biolink:NamedThing mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. got7fsn_ti mitochondrion organization and biogenesis|mitochondria organization|mitochondrion organisation biological_process owl:Class GO:0006874 biolink:NamedThing cellular calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. got7fsn_ti regulation of calcium ion concentration biological_process owl:Class GO:0006875 biolink:NamedThing cellular metal ion homeostasis Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell. got7fsn_ti cellular heavy metal ion homeostasis biological_process owl:Class GO:0016125 biolink:NamedThing sterol metabolic process The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. got7fsn_ti sterol metabolism biological_process owl:Class GO:0043726 biolink:NamedThing 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate. got7fsn_ti pyrimidine phosphatase activity GO:0019173 MetaCyc:RIBOPHOSPHAT-RXN|RHEA:25197 molecular_function owl:Class GO:0006036 biolink:NamedThing cuticle chitin catabolic process The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. got7fsn_ti cuticle chitin breakdown|cuticle chitin catabolism|cuticle chitin degradation biological_process owl:Class GO:0006032 biolink:NamedThing chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. got7fsn_ti beta-1,4-linked N-acetylglucosamine catabolic process|chitin breakdown|chitin degradation|chitin catabolism|beta-1,4-linked N-acetylglucosamine catabolism biological_process owl:Class GO:0045204 biolink:NamedThing MAPK export from nucleus The directed movement of a MAP kinase from the nucleus to the cytoplasm. got7fsn_ti MAPK-nucleus export|MAPK export out of nucleus|MAPK export from cell nucleus|MAPK transport from nucleus to cytoplasm|cytoplasmic translocation of mitogen-activated protein kinase|cytoplasmic translocation of MAP kinase biological_process owl:Class GO:0006611 biolink:NamedThing protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm. got7fsn_ti protein export out of nucleus|protein transport from nucleus to cytoplasm|protein export from cell nucleus|protein-nucleus export|copper-induced protein export from nucleus GO:0097349 biological_process owl:Class GO:0050959 biolink:NamedThing echolocation Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning. got7fsn_ti perception of environment using reflected sound waves|biological sonar Wikipedia:Echolocation biological_process owl:Class GO:0050877 biolink:NamedThing nervous system process A organ system process carried out by any of the organs or tissues of neurological system. got7fsn_ti neurophysiological process|pan-neural process|neurological system process https://github.com/geneontology/go-ontology/issues/13824 biological_process owl:Class GO:1904058 biolink:NamedThing positive regulation of sensory perception of pain Any process that activates or increases the frequency, rate or extent of sensory perception of pain. got7fsn_ti upregulation of sensory perception of pain|positive regulation of perception of physiological pain|activation of nociception|activation of sensory perception of pain|up-regulation of perception of physiological pain|up-regulation of sensory perception of pain|up regulation of sensory perception of pain|up regulation of nociception|upregulation of perception of physiological pain|positive regulation of nociception|upregulation of nociception|up regulation of perception of physiological pain|activation of perception of physiological pain|up-regulation of nociception sl 2015-03-18T20:34:03Z biological_process owl:Class GO:0051930 biolink:NamedThing regulation of sensory perception of pain Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. got7fsn_ti biological_process owl:Class GO:0036509 biolink:NamedThing trimming of terminal mannose on B branch The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. got7fsn_ti conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2|conversion of M9 to M8B|glycoprotein mannose trimming on B branch Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. bf 2015-06-11T14:02:44Z KEGG_REACTION:R06722 biological_process owl:Class GO:1904380 biolink:NamedThing endoplasmic reticulum mannose trimming Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC). got7fsn_ti protein alpha-1,2-demannosylation in ER|protein alpha-1,2-demannosylation in endoplasmic reticulum|glycoprotein mannose trimming in endoplasmic reticulum quality control compartment|protein alpha-1,2-demannosylation in endoplasmic reticulum quality control compartment|ER protein alpha-1,2-demannosylation|protein alpha-1,2-demannosylation in ER-derived quality control compartment|glycoprotein mannose trimming in ERQC|protein alpha-1,2-demannosylation in ER quality control compartment|glycoprotein mannose trimming in ER-derived quality control compartment|ER mannose trimming|glycoprotein mannose trimming in ER quality control compartment|protein alpha-1,2-demannosylation in ERQC bf 2015-06-23T09:35:41Z biological_process owl:Class GO:1900046 biolink:NamedThing regulation of hemostasis Any process that modulates the frequency, rate or extent of hemostasis. got7fsn_ti jl 2012-01-19T03:23:38Z biological_process owl:Class GO:0002519 biolink:NamedThing natural killer cell tolerance induction Tolerance induction of natural killer cells. got7fsn_ti NK cell tolerance induction biological_process owl:Class GO:0002507 biolink:NamedThing tolerance induction A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. got7fsn_ti biological_process owl:Class GO:0072417 biolink:NamedThing response to spindle checkpoint signaling A process that occurs in response to signals generated as a result of spindle checkpoint signaling. got7fsn_ti response to signal involved in spindle checkpoint|spindle checkpoint effector process mah 2010-12-08T03:56:04Z biological_process owl:Class GO:0072396 biolink:NamedThing response to cell cycle checkpoint signaling A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling. got7fsn_ti response to signal involved in G1/S transition checkpoint|response to G2/M transition checkpoint signaling|cell cycle checkpoint effector process|G2/M transition checkpoint effector process|response to signal involved in cell cycle checkpoint|response to G1/S transition checkpoint signaling|G1/S transition checkpoint effector process|response to signal involved in G2/M transition checkpoint mah 2010-12-08T03:05:46Z GO:0072405|GO:0072408 biological_process owl:Class GO:0005451 biolink:NamedThing monovalent cation:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). got7fsn_ti monovalent cation:hydrogen antiporter activity Reactome:R-HSA-2889070 molecular_function owl:Class GO:0005141 biolink:NamedThing interleukin-10 receptor binding Binding to an interleukin-10 receptor. got7fsn_ti interleukin-10 receptor ligand|IL-10 molecular_function owl:Class GO:0019982 biolink:NamedThing interleukin-7 binding Binding to interleukin-7. got7fsn_ti IL-7 binding molecular_function owl:Class GO:0090493 biolink:NamedThing catecholamine uptake The directed movement of catecholamine into a cell. got7fsn_ti tb 2012-10-17T11:06:17Z biological_process owl:Class GO:0051937 biolink:NamedThing catecholamine transport The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. got7fsn_ti biological_process owl:Class GO:0071227 biolink:NamedThing cellular response to molecule of oomycetes origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin. got7fsn_ti cellular response to oomycetes associated molecule mah 2009-12-03T01:55:09Z biological_process owl:Class GO:1990200 biolink:NamedThing SsuD-SsuE complex A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation. got7fsn_ti two-component alkanesulfonate monooxygenase system bhm 2013-10-03T12:59:26Z cellular_component owl:Class GO:0039684 biolink:NamedThing rolling circle single-stranded viral DNA replication A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome. got7fsn_ti ssDNA rolling circle replication bf 2013-10-17T14:15:48Z VZ:1941 biological_process owl:Class GO:0039682 biolink:NamedThing rolling circle viral DNA replication A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA. got7fsn_ti bf 2013-10-17T14:13:51Z biological_process owl:Class GO:0008682 biolink:NamedThing 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone. got7fsn_ti demethoxyubiquinone monooxygenase|demethoxy-ubiquinone hydroxylase RHEA:50908|EC:1.14.99.60|MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN molecular_function owl:Class GO:0004497 biolink:NamedThing monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. got7fsn_ti hydroxylase activity Reactome:R-HSA-211910|Reactome:R-HSA-211962|Reactome:R-HSA-5662692|Reactome:R-HSA-6786239|Reactome:R-HSA-76456|Reactome:R-HSA-76354|Reactome:R-HSA-2161814|Reactome:R-HSA-211988|Reactome:R-HSA-213175|Reactome:R-HSA-9018874|Reactome:R-HSA-9027042|Reactome:R-HSA-143468|Reactome:R-HSA-215526|Reactome:R-HSA-156526|Reactome:R-HSA-76373|Reactome:R-HSA-211959|Reactome:R-HSA-76426|Reactome:R-HSA-5423678|Reactome:R-HSA-211948|Reactome:R-HSA-5423672|Reactome:R-HSA-211924|Reactome:R-HSA-2161795|Reactome:R-HSA-5605147|Reactome:R-HSA-217258|Reactome:R-HSA-9037761|Reactome:R-HSA-2161899|Reactome:R-HSA-9027321|Reactome:R-HSA-5662662|Reactome:R-HSA-76386|Reactome:R-HSA-76466|Reactome:R-HSA-76416|Reactome:R-HSA-212004|Reactome:R-HSA-211960|Reactome:R-HSA-2161940|Reactome:R-HSA-211919|Reactome:R-HSA-5423664|Reactome:R-HSA-76472|Reactome:R-HSA-76475|Reactome:R-HSA-76434|Reactome:R-HSA-211968|Reactome:R-HSA-212005|Reactome:R-HSA-211991|Reactome:R-HSA-5602272|Reactome:R-HSA-2162191|Reactome:R-HSA-211882|Reactome:R-HSA-9027043|Reactome:R-HSA-211951|Reactome:R-HSA-76397|Reactome:R-HSA-5423647|Reactome:R-HSA-9027044|Reactome:R-HSA-9027302|Reactome:R-HSA-5602242|Reactome:R-HSA-5602295|Reactome:R-HSA-211904|Reactome:R-HSA-2161890|Reactome:R-HSA-5663050|Reactome:R-HSA-8865107|Reactome:R-HSA-211929 molecular_function owl:Class GO:0031205 biolink:NamedThing endoplasmic reticulum Sec complex An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex. got7fsn_ti cellular_component owl:Class GO:0031946 biolink:NamedThing regulation of glucocorticoid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. got7fsn_ti biological_process owl:Class GO:0090030 biolink:NamedThing regulation of steroid hormone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. got7fsn_ti tb 2009-08-03T10:38:27Z biological_process owl:Class GO:0045821 biolink:NamedThing positive regulation of glycolytic process Any process that activates or increases the frequency, rate or extent of glycolysis. got7fsn_ti upregulation of glycolysis|stimulation of glycolysis|activation of glycolysis|up-regulation of glycolysis|up regulation of glycolysis biological_process owl:Class GO:0031331 biolink:NamedThing positive regulation of cellular catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. got7fsn_ti stimulation of cellular catabolic process|up-regulation of cellular catabolic process|positive regulation of cellular degradation|positive regulation of cellular breakdown|activation of cellular catabolic process|upregulation of cellular catabolic process|up regulation of cellular catabolic process|positive regulation of cellular catabolism biological_process owl:Class GO:0003976 biolink:NamedThing UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. got7fsn_ti UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity|N-acetylglucosaminylphosphotransferase activity|lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity|UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity|N-acetylglucosaminyl phosphotransferase activity|UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity|UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity|UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity MetaCyc:2.7.8.17-RXN|EC:2.7.8.17|RHEA:13581 molecular_function owl:Class GO:0032302 biolink:NamedThing MutSbeta complex A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. got7fsn_ti MMR complex|MSH2/MSH3 complex cellular_component owl:Class GO:0031157 biolink:NamedThing regulation of aggregate size involved in sorocarp development Any process that modulates the size of the aggregate formed during sorocarp formation. got7fsn_ti regulation of aggregation during fruiting body formation|regulation of aggregation during fruiting body biosynthesis biological_process owl:Class GO:0047025 biolink:NamedThing 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]. got7fsn_ti 3-oxoacyl-acyl-carrier-protein reductase (NADH)|3-oxoacyl-ACP reductase (NADH) activity|3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity|3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity|(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity EC:1.1.1.212|MetaCyc:1.1.1.212-RXN|RHEA:19913 molecular_function owl:Class GO:0090060 biolink:NamedThing regulation of metaxylem development Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed. got7fsn_ti tb 2009-08-11T03:14:54Z biological_process owl:Class GO:2000026 biolink:NamedThing regulation of multicellular organismal development Any process that modulates the frequency, rate or extent of multicellular organismal development. got7fsn_ti tb 2010-08-05T11:25:59Z biological_process owl:Class GO:0052103 biolink:NamedThing induction by symbiont of host induced systemic resistance Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti induction by organism of induced systemic resistance in other organism involved in symbiotic interaction|induction by symbiont of induced systemic resistance in host|up-regulation by symbiont of induced systemic resistance in host|positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction|up regulation by symbiont of induced systemic resistance in host|positive regulation by symbiont of host induced systemic resistance|activation by symbiont of induced systemic resistance in host|upregulation by symbiont of induced systemic resistance in host|stimulation by symbiont of induced systemic resistance in host|positive regulation by symbiont of induced systemic resistance in host|activation by organism of ISR in host|activation by organism of induced systemic resistance in host|induction by organism of ISR in host GO:0052532|GO:0052533|GO:0052288 biological_process owl:Class GO:0052159 biolink:NamedThing modulation by symbiont of host induced systemic resistance Any process in which a symbiont modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of induced systemic resistance in host|modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction GO:0052298 biological_process owl:Class GO:0001571 biolink:NamedThing non-tyrosine kinase fibroblast growth factor receptor activity Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity. got7fsn_ti non-tyrosine kinase FGF receptor activity|non-tyrosine kinase FGFR activity molecular_function owl:Class GO:1904362 biolink:NamedThing regulation of calcitonin secretion Any process that modulates the frequency, rate or extent of calcitonin secretion. got7fsn_ti sl 2015-06-15T17:54:52Z biological_process owl:Class GO:0090276 biolink:NamedThing regulation of peptide hormone secretion Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. got7fsn_ti tb 2010-02-05T02:56:39Z biological_process owl:Class GO:0044403 biolink:NamedThing biological process involved in symbiotic interaction A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts. got7fsn_ti commensalism|symbiotic interaction between organisms|parasitism|symbiotic interaction|symbiosis|symbiotic interaction between species|symbiotic interaction between host and organism|host-pathogen interaction|symbiotic process|symbiosis, encompassing mutualism through parasitism https://github.com/geneontology/go-ontology/issues/14807|https://github.com/geneontology/go-ontology/issues/20191 GO:0072519|GO:0085031|GO:0043298|GO:0044404 biological_process owl:Class GO:0044419 biolink:NamedThing biological process involved in interspecies interaction between organisms Any process evolved to enable an interaction with an organism of a different species. got7fsn_ti interspecies interaction|interaction with another species|interspecies interaction between organisms|interspecies interaction with other organisms https://github.com/geneontology/go-ontology/issues/20191 biological_process owl:Class GO:0045049 biolink:NamedThing protein insertion into ER membrane by N-terminal cleaved signal sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER. got7fsn_ti protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence|N-terminal cleaved signal sequence mediated protein insertion into ER membrane|protein insertion into ER membrane, N-terminal cleaved signal sequence mediated|protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence|protein-ER insertion by N-terminal cleaved signal sequence biological_process owl:Class GO:0045048 biolink:NamedThing protein insertion into ER membrane The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. got7fsn_ti positioning of protein in ER membrane|integral ER membrane protein localization|integral ER membrane protein positioning|protein insertion into endoplasmic reticulum membrane|localization of protein in ER membrane|protein-ER insertion|protein-endoplasmic reticulum insertion biological_process owl:Class GO:0034918 biolink:NamedThing 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0930 molecular_function owl:Class GO:0097341 biolink:NamedThing zymogen inhibition Any process that prevents the proteolytic processing of an inactive enzyme to an active form. got7fsn_ti prevention of zymogen activation pr 2012-06-18T11:25:45Z biological_process owl:Class GO:0010955 biolink:NamedThing negative regulation of protein processing Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. got7fsn_ti negative regulation of protein maturation by peptide bond cleavage tb 2009-04-27T12:10:19Z biological_process owl:Class GO:0045105 biolink:NamedThing intermediate filament polymerization or depolymerization Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament. got7fsn_ti biological_process owl:Class GO:0043933 biolink:NamedThing protein-containing complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. got7fsn_ti protein complex subunit organization|macromolecular complex organization|cellular macromolecular complex subunit organisation|macromolecular complex subunit organisation|protein complex subunit organisation|cellular macromolecular complex organization|cellular macromolecular complex subunit organization|macromolecular complex subunit organization mah 2010-09-08T10:01:42Z GO:0034600|GO:0071822|GO:0034621 biological_process owl:Class GO:0071747 biolink:NamedThing IgA B cell receptor complex An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti membrane-bound IgA1|surface IgA1|surface IgA|membrane-bound IgA2|membrane-bound IgA|surface IgA2 Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class GO:0071745 biolink:NamedThing IgA immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti IgA1 antibody|IgA2 antibody Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class GO:0048790 biolink:NamedThing maintenance of presynaptic active zone structure A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters. got7fsn_ti maintenance of pre-synaptic active zone structure biological_process owl:Class GO:1990709 biolink:NamedThing presynaptic active zone organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone. got7fsn_ti presynaptic active zone organisation pr 2015-03-20T10:16:24Z biological_process owl:Class GO:0097100 biolink:NamedThing supercoiled DNA binding Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. got7fsn_ti pr 2011-07-12T03:28:57Z molecular_function owl:Class GO:0003690 biolink:NamedThing double-stranded DNA binding Binding to double-stranded DNA. got7fsn_ti dsDNA binding molecular_function owl:Class GO:0008174 biolink:NamedThing mRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. got7fsn_ti molecular_function owl:Class GO:0018132 biolink:NamedThing peptide cross-linking via L-cysteine oxazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti RESID:AA0238 biological_process owl:Class GO:0010796 biolink:NamedThing regulation of multivesicular body size Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles. got7fsn_ti biological_process owl:Class GO:0051036 biolink: