id category name description provided_by synonym 0000233 0000589 0100001 close_match comment consider created_by creation_date default_namespace deprecated has_alternative_id has_o_b_o_format_version has_o_b_o_namespace is_class_level is_metadata_tag knowledge_source license logical_interpretation object predicate relation shorthand subject type version GO:2000071 biolink:NamedThing regulation of defense response by callose deposition Any process that modulates the frequency, rate or extent of defense response by callose deposition. tmpzr1t_l9r_go_relaxed.owl regulation of callose localization during defense response|regulation of callose deposition during defense response tb 2010-08-23T11:34:01Z biological_process owl:Class GO:0065007 biolink:NamedThing biological regulation Any process that modulates a measurable attribute of any biological process, quality or function. tmpzr1t_l9r_go_relaxed.owl regulation biological_process owl:Class GO:0070665 biolink:NamedThing positive regulation of leukocyte proliferation Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. tmpzr1t_l9r_go_relaxed.owl activation of leukocyte proliferation|upregulation of leukocyte proliferation|stimulation of leukocyte proliferation|up-regulation of leukocyte proliferation|up regulation of leukocyte proliferation mah 2009-05-28T05:36:46Z biological_process owl:Class GO:0070663 biolink:NamedThing regulation of leukocyte proliferation Any process that modulates the frequency, rate or extent of leukocyte proliferation. tmpzr1t_l9r_go_relaxed.owl mah 2009-05-28T05:30:39Z biological_process owl:Class GO:0015537 biolink:NamedThing xanthosine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in). tmpzr1t_l9r_go_relaxed.owl xanthosine:hydrogen ion symporter activity|xanthosine permease activity molecular_function owl:Class GO:0015506 biolink:NamedThing nucleoside:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in). tmpzr1t_l9r_go_relaxed.owl nucleoside:hydrogen symporter activity|nucleoside:hydrogen ion symporter activity|nucleoside permease activity GO:0015536 molecular_function owl:Class GO:0031585 biolink:NamedThing regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. tmpzr1t_l9r_go_relaxed.owl regulation of inositol-1,4,5-triphosphate receptor activity|regulation of IP3 receptor activity biological_process owl:Class GO:2001257 biolink:NamedThing regulation of cation channel activity Any process that modulates the frequency, rate or extent of cation channel activity. tmpzr1t_l9r_go_relaxed.owl regulation of cation diffusion facilitator activity|regulation of nonselective cation channel activity vk 2011-12-07T07:14:43Z biological_process owl:Class GO:0034443 biolink:NamedThing negative regulation of lipoprotein oxidation Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation. tmpzr1t_l9r_go_relaxed.owl inhibition of lipoprotein oxidation biological_process owl:Class GO:0050748 biolink:NamedThing negative regulation of lipoprotein metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. tmpzr1t_l9r_go_relaxed.owl down regulation of lipoprotein metabolic process|inhibition of lipoprotein metabolic process|down-regulation of lipoprotein metabolic process|negative regulation of lipoprotein metabolism|downregulation of lipoprotein metabolic process biological_process owl:Class GO:0043395 biolink:NamedThing heparan sulfate proteoglycan binding Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. tmpzr1t_l9r_go_relaxed.owl heparin proteoglycan binding molecular_function owl:Class GO:1901681 biolink:NamedThing sulfur compound binding Binding to a sulfur compound. tmpzr1t_l9r_go_relaxed.owl sulfur molecular entity binding pr 2012-11-26T20:45:23Z molecular_function owl:Class GO:0007523 biolink:NamedThing larval visceral muscle development The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0048569 biolink:NamedThing post-embryonic animal organ development Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. tmpzr1t_l9r_go_relaxed.owl post-embryonic animal organogenesis biological_process owl:Class GO:0033021 biolink:NamedThing cyclopentanol biosynthetic process The chemical reactions and pathways resulting in the formation of cyclopentanol. tmpzr1t_l9r_go_relaxed.owl cyclopentanol synthesis|cyclopentanol biosynthesis|cyclopentanol anabolism|cyclopentanol formation biological_process owl:Class GO:0046165 biolink:NamedThing alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. tmpzr1t_l9r_go_relaxed.owl alcohol formation|alcohol synthesis|alcohol anabolism|alcohol biosynthesis biological_process owl:Class GO:0061291 biolink:NamedThing canonical Wnt signaling pathway involved in ureteric bud branching The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. tmpzr1t_l9r_go_relaxed.owl canonical Wnt receptor signalling pathway involved in ureteric bud branching|canonical Wnt receptor signaling pathway involved in ureteric bud branching dph 2010-09-03T12:15:19Z biological_process owl:Class GO:0060070 biolink:NamedThing canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. tmpzr1t_l9r_go_relaxed.owl canonical Wnt receptor signaling pathway|canonical Wnt-activated signaling pathway|Wnt receptor signaling pathway through beta-catenin|Wnt receptor signalling pathway through beta-catenin|Wnt receptor signaling pathway via beta-catenin|frizzled-1 receptor signaling pathway biological_process owl:Class GO:1904525 biolink:NamedThing positive regulation of DNA amplification Any process that activates or increases the frequency, rate or extent of DNA amplification. tmpzr1t_l9r_go_relaxed.owl activation of DNA amplification|up regulation of DNA amplification|upregulation of DNA amplification|up-regulation of DNA amplification mcc 2015-07-29T16:24:25Z biological_process owl:Class GO:1904523 biolink:NamedThing regulation of DNA amplification Any process that modulates the frequency, rate or extent of DNA amplification. tmpzr1t_l9r_go_relaxed.owl mcc 2015-07-29T16:24:13Z biological_process owl:Class GO:0033122 biolink:NamedThing negative regulation of purine nucleotide catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides. tmpzr1t_l9r_go_relaxed.owl negative regulation of purine nucleotide catabolism|negative regulation of purine nucleotide degradation|negative regulation of purine nucleotide breakdown biological_process owl:Class GO:0030812 biolink:NamedThing negative regulation of nucleotide catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. tmpzr1t_l9r_go_relaxed.owl negative regulation of nucleotide catabolism|negative regulation of nucleotide degradation|down-regulation of nucleotide catabolic process|down regulation of nucleotide catabolic process|inhibition of nucleotide catabolic process|downregulation of nucleotide catabolic process|negative regulation of nucleotide breakdown biological_process owl:Class GO:0010147 biolink:NamedThing fructan catabolic process The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues. tmpzr1t_l9r_go_relaxed.owl levan catabolic process|fructan catabolism|levan catabolism|fructan breakdown|fructan degradation MetaCyc:PWY-862 biological_process owl:Class GO:0010145 biolink:NamedThing fructan metabolic process The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues. tmpzr1t_l9r_go_relaxed.owl fructan metabolism|levan metabolic process biological_process owl:Class GO:0010922 biolink:NamedThing positive regulation of phosphatase activity Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0035306 biolink:NamedThing positive regulation of dephosphorylation Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. tmpzr1t_l9r_go_relaxed.owl stimulation of dephosphorylation|up regulation of dephosphorylation|upregulation of dephosphorylation|activation of dephosphorylation|up-regulation of dephosphorylation biological_process owl:Class GO:0016055 biolink:NamedThing Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. tmpzr1t_l9r_go_relaxed.owl Wingless signaling pathway|Wg signalling pathway|Wnt-activated signaling pathway|frizzled signaling pathway|Wnt receptor signaling pathway|Wnt receptor signalling pathway|frizzled signalling pathway|Wg signaling pathway|Wingless signalling pathway GO:0007222 biological_process owl:Class GO:1905114 biolink:NamedThing cell surface receptor signaling pathway involved in cell-cell signaling Any cell surface receptor signaling pathway that is involved in cell-cell signaling. tmpzr1t_l9r_go_relaxed.owl cell surface receptor linked signaling pathway involved in cell-cell signalling|cell surface receptor linked signaling pathway involved in cell-cell signaling|cell surface receptor signaling pathway involved in cell-cell signalling|cell surface receptor linked signalling pathway involved in cell-cell signalling|cell surface receptor linked signalling pathway involved in cell-cell signaling|cell surface receptor linked signal transduction involved in cell-cell signalling|cell surface receptor linked signal transduction involved in cell-cell signaling dos 2016-04-06T16:59:57Z biological_process owl:Class GO:0014058 biolink:NamedThing negative regulation of acetylcholine secretion, neurotransmission Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine. tmpzr1t_l9r_go_relaxed.owl inhibition of acetylcholine secretion|down regulation of acetylcholine secretion|down-regulation of acetylcholine secretion|downregulation of acetylcholine secretion biological_process owl:Class GO:0043271 biolink:NamedThing negative regulation of ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl downregulation of ion transport|down regulation of ion transport|inhibition of ion transport|down-regulation of ion transport biological_process owl:Class GO:1900602 biolink:NamedThing endocrocin biosynthetic process The chemical reactions and pathways resulting in the formation of endocrocin. tmpzr1t_l9r_go_relaxed.owl endocrocin formation|endocrocin anabolism|endocrocin biosynthesis|endocrocin synthesis di 2012-05-15T06:57:42Z biological_process owl:Class GO:1900600 biolink:NamedThing endocrocin metabolic process The chemical reactions and pathways involving endocrocin. tmpzr1t_l9r_go_relaxed.owl endocrocin metabolism di 2012-05-15T06:57:14Z biological_process owl:Class GO:0070292 biolink:NamedThing N-acylphosphatidylethanolamine metabolic process The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group. tmpzr1t_l9r_go_relaxed.owl N-acylphosphatidylethanolamine metabolism|NAPE metabolism|NAPE metabolic process biological_process owl:Class GO:1901564 biolink:NamedThing organonitrogen compound metabolic process The chemical reactions and pathways involving organonitrogen compound. tmpzr1t_l9r_go_relaxed.owl organonitrogen compound metabolism pr 2012-11-04T15:17:52Z biological_process owl:Class GO:1990661 biolink:NamedThing S100A8 complex A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4). tmpzr1t_l9r_go_relaxed.owl S100A8 homodimer An example of this is S100A8 in human (UniProt symbol P27005) in PMID:25417112 (inferred from direct assay). bhm 2015-02-25T15:33:32Z cellular_component owl:Class GO:0032991 biolink:NamedThing protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. tmpzr1t_l9r_go_relaxed.owl protein containing complex|macromolecule complex|protein complex|macromolecular complex|protein-protein complex A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. GO:0043234 cellular_component owl:Class GO:0019543 biolink:NamedThing propionate catabolic process The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid. tmpzr1t_l9r_go_relaxed.owl propionate degradation|propionate breakdown|propionate catabolism biological_process owl:Class GO:0019541 biolink:NamedThing propionate metabolic process The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants. tmpzr1t_l9r_go_relaxed.owl propanoate metabolic process|propionate metabolism|propanoate metabolism biological_process owl:Class GO:0051007 biolink:NamedThing squalene-hopene cyclase activity Catalysis of the reaction: squalene = hop-22(29)-ene. tmpzr1t_l9r_go_relaxed.owl squalene mutase (cyclizing)|squalene:hopene cyclase activity MetaCyc:5.4.99.17-RXN|RHEA:17637|EC:5.4.99.17 molecular_function owl:Class GO:0034072 biolink:NamedThing squalene cyclase activity Catalysis of the reaction: squalene = triterpene. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0051129 biolink:NamedThing negative regulation of cellular component organization Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. tmpzr1t_l9r_go_relaxed.owl inhibition of cell organization|negative regulation of cellular component organization and biogenesis|downregulation of cell organization|down regulation of cell organization|down-regulation of cell organization|negative regulation of cell organisation biological_process owl:Class GO:0051479 biolink:NamedThing mannosylglycerate biosynthetic process The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms. tmpzr1t_l9r_go_relaxed.owl mannosylglycerate synthesis|mannosylglycerate biosynthesis|mannosylglycerate formation|mannosylglycerate anabolism biological_process owl:Class GO:0016138 biolink:NamedThing glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. tmpzr1t_l9r_go_relaxed.owl O-glycoside anabolism|O-glycoside synthesis|glycoside anabolism|glycoside formation|O-glycoside formation|glycoside biosynthesis|O-glycoside biosynthesis|glycoside synthesis|O-glycoside biosynthetic process GO:0016141 biological_process owl:Class GO:0052783 biolink:NamedThing reuteran metabolic process The chemical reactions and pathways involving reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages. tmpzr1t_l9r_go_relaxed.owl ai 2011-10-04T09:16:35Z biological_process owl:Class GO:0030978 biolink:NamedThing alpha-glucan metabolic process The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds. tmpzr1t_l9r_go_relaxed.owl alpha-glucan metabolism biological_process owl:Class GO:0035038 biolink:NamedThing female pronucleus assembly Assembly of the haploid nucleus of the unfertilized egg. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0070925 biolink:NamedThing organelle assembly The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. tmpzr1t_l9r_go_relaxed.owl mah 2009-09-15T03:00:51Z biological_process owl:Class GO:0018705 biolink:NamedThing 1,2-dichloroethene reductive dehalogenase activity Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride. tmpzr1t_l9r_go_relaxed.owl 1,2-dichloroethylene reductive dehalogenase activity UM-BBD_enzymeID:e0272 molecular_function owl:Class GO:0016491 biolink:NamedThing oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. tmpzr1t_l9r_go_relaxed.owl oxidoreductase activity, acting on other substrates|redox activity Reactome:R-HSA-9026917|Reactome:R-HSA-8878581|Reactome:R-HSA-9024624|Reactome:R-HSA-9026001|Reactome:R-HSA-209921|Reactome:R-HSA-8936442|Reactome:R-HSA-1614362|Reactome:R-HSA-9027033|Reactome:R-HSA-9693722|Reactome:R-HSA-5662660|Reactome:R-HSA-9025007|EC:1.-.-.-|Reactome:R-HSA-390425|Reactome:R-HSA-3095889|Reactome:R-HSA-9024630|Reactome:R-HSA-209960|Reactome:R-HSA-9020249|Reactome:R-HSA-390438|Reactome:R-HSA-9020260 molecular_function owl:Class GO:0002175 biolink:NamedThing protein localization to paranode region of axon A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon. tmpzr1t_l9r_go_relaxed.owl protein localisation to paranode region of axon hjd 2010-11-15T10:28:20Z biological_process owl:Class GO:0034613 biolink:NamedThing cellular protein localization Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. tmpzr1t_l9r_go_relaxed.owl channel localizer activity|cellular protein localisation GO:0016249 biological_process owl:Class GO:0000107 biolink:NamedThing imidazoleglycerol-phosphate synthase activity Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+). tmpzr1t_l9r_go_relaxed.owl imidazole-glycerol-phosphate synthase activity|glutamine amidotransferase:cyclase activity|imidazole glycerol phosphate synthase activity|imidazoleglycerol phosphate synthase activity RHEA:24793|MetaCyc:GLUTAMIDOTRANS-RXN molecular_function owl:Class GO:0016763 biolink:NamedThing pentosyltransferase activity Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). tmpzr1t_l9r_go_relaxed.owl transferase activity, transferring pentosyl groups https://github.com/geneontology/go-ontology/issues/20486 EC:2.4.2.-|Reactome:R-HSA-112266|Reactome:R-HSA-112265 molecular_function owl:Class GO:0097666 biolink:NamedThing SCF-Met30/Pof1 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe). tmpzr1t_l9r_go_relaxed.owl pr 2014-10-06T10:27:49Z cellular_component owl:Class GO:0019005 biolink:NamedThing SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). tmpzr1t_l9r_go_relaxed.owl SCF complex substrate recognition subunit|Skp1/Cul1/F-box protein complex|SCF complex|CRL1 complex|CDL1 complex|Cul1-RING ubiquitin ligase complex|cullin-RING ligase 1 Wikipedia:SCF_complex cellular_component owl:Class GO:2001037 biolink:NamedThing positive regulation of tongue muscle cell differentiation Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation. tmpzr1t_l9r_go_relaxed.owl yaf 2011-08-24T11:10:22Z biological_process owl:Class GO:0046330 biolink:NamedThing positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. tmpzr1t_l9r_go_relaxed.owl stimulation of JNK cascade|upregulation of JNK cascade|up regulation of JNK cascade|activation of JNK cascade|up-regulation of JNK cascade biological_process owl:Class GO:0072235 biolink:NamedThing metanephric distal tubule development The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule. tmpzr1t_l9r_go_relaxed.owl mah 2010-03-18T03:45:37Z biological_process owl:Class GO:0072234 biolink:NamedThing metanephric nephron tubule development The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros. tmpzr1t_l9r_go_relaxed.owl mah 2010-03-18T03:41:23Z biological_process owl:Class GO:0097673 biolink:NamedThing SCF-Ucc1 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae. tmpzr1t_l9r_go_relaxed.owl SCF-YLR224W ubiquitin ligase complex pr 2014-10-06T10:30:31Z cellular_component owl:Class GO:1903242 biolink:NamedThing regulation of cardiac muscle hypertrophy in response to stress Any process that modulates the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. tmpzr1t_l9r_go_relaxed.owl rl 2014-08-01T16:31:36Z biological_process owl:Class GO:0010611 biolink:NamedThing regulation of cardiac muscle hypertrophy Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0140407 biolink:NamedThing L-alanine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out). tmpzr1t_l9r_go_relaxed.owl pg 2019-12-11T14:17:48Z molecular_function owl:Class GO:0015180 biolink:NamedThing L-alanine transmembrane transporter activity Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. tmpzr1t_l9r_go_relaxed.owl L-alanine transporter activity molecular_function owl:Class GO:1902634 biolink:NamedThing 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. tmpzr1t_l9r_go_relaxed.owl 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name. di 2014-01-18T00:34:36Z biological_process owl:Class GO:0031161 biolink:NamedThing phosphatidylinositol catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. tmpzr1t_l9r_go_relaxed.owl PtdIns catabolic process|phosphatidylinositol breakdown|PtdIns catabolism|phosphatidylinositol degradation|phosphatidylinositol catabolism biological_process owl:Class GO:0002452 biolink:NamedThing B cell receptor editing The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor. tmpzr1t_l9r_go_relaxed.owl B-lymphocyte receptor editing|B lymphocyte receptor editing|B-cell receptor editing biological_process owl:Class GO:0016447 biolink:NamedThing somatic recombination of immunoglobulin gene segments The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. tmpzr1t_l9r_go_relaxed.owl somatic recombination of antibody gene segments biological_process owl:Class GO:0106003 biolink:NamedThing amyloid-beta complex Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease. tmpzr1t_l9r_go_relaxed.owl amyloid-beta protein 40/42 complex|amyloid-beta protein 42 complex|beta-amyloid complex|heterodimer of amyloid beta protein|amyloid beta trimer|ADDL complex|betaA complex|heterotrimer of amyloid beta protein|amyloid beta heterodimer|amyloid-beta protein 40 complex|amyloid beta heterooligomer|homodimer of amyloid beta protein|amyloid beta oligomer|beta amyloid complex|amyloid beta heterotrimer|amyloid beta dimer|Abeta-derived diffusible ligand complex|amyloid beta homooligomer|homotrimer of amyloid beta protein|Abeta complex|amyloid beta homotrimer|heterooligomer of amyloid beta protein|amyloid beta homodimer|homooligomer of amyloid beta protein|amyloid beta complex An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay). hjd 2017-03-15T19:19:29Z cellular_component owl:Class GO:0140057 biolink:NamedThing vacuole-mitochondria membrane tethering The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. tmpzr1t_l9r_go_relaxed.owl pg 2017-06-27T10:31:12Z biological_process owl:Class GO:0140056 biolink:NamedThing organelle localization by membrane tethering The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. tmpzr1t_l9r_go_relaxed.owl pg 2017-06-27T09:58:51Z biological_process owl:Class GO:1904051 biolink:NamedThing regulation of protein targeting to vacuole involved in autophagy Any process that modulates the frequency, rate or extent of protein targeting to vacuole involved in autophagy. tmpzr1t_l9r_go_relaxed.owl An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype). pad 2015-03-17T13:54:16Z biological_process owl:Class GO:0051998 biolink:NamedThing protein carboxyl O-methyltransferase activity Catalysis of the transfer of a methyl group to a carboxyl group on a protein. tmpzr1t_l9r_go_relaxed.owl protein carboxyl methyltransferase activity ai 2010-07-20T09:23:00Z molecular_function owl:Class GO:0008276 biolink:NamedThing protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-9632182 molecular_function owl:Class GO:0005916 biolink:NamedThing fascia adherens A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Fascia_adherens cellular_component owl:Class GO:0005911 biolink:NamedThing cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. tmpzr1t_l9r_go_relaxed.owl cell-cell contact region|cell-cell contact zone|intercellular junction https://github.com/geneontology/go-ontology/issues/22122 NIF_Subcellular:sao1922892319 cellular_component owl:Class GO:0102249 biolink:NamedThing phosphatidylcholine:diacylglycerol cholinephosphotransferase activity Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-12386 molecular_function owl:Class GO:0016780 biolink:NamedThing phosphotransferase activity, for other substituted phosphate groups Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-163069|Reactome:R-HSA-162742|EC:2.7.8.- molecular_function owl:Class GO:1900590 biolink:NamedThing violaceol I biosynthetic process The chemical reactions and pathways resulting in the formation of violaceol I. tmpzr1t_l9r_go_relaxed.owl violaceol I anabolism|violaceol I formation|violaceol I biosynthesis|violaceol I synthesis di 2012-05-15T06:51:16Z biological_process owl:Class GO:1901503 biolink:NamedThing ether biosynthetic process The chemical reactions and pathways resulting in the formation of ether. tmpzr1t_l9r_go_relaxed.owl ether synthesis|ether formation|ether biosynthesis|ether anabolism pr 2012-10-17T09:42:47Z biological_process owl:Class GO:0006684 biolink:NamedThing sphingomyelin metabolic process The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. tmpzr1t_l9r_go_relaxed.owl sphingomyelin metabolism biological_process owl:Class GO:0006665 biolink:NamedThing sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). tmpzr1t_l9r_go_relaxed.owl sphingolipid metabolism biological_process owl:Class GO:0006414 biolink:NamedThing translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. tmpzr1t_l9r_go_relaxed.owl translation elongation|protein synthesis elongation GO:0006442|GO:0006455 biological_process owl:Class GO:0034645 biolink:NamedThing cellular macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl cellular macromolecule biosynthesis|cellular biopolymer biosynthetic process|cellular macromolecule formation|cellular macromolecule synthesis|cellular macromolecule anabolism GO:0034961 biological_process owl:Class GO:0006208 biolink:NamedThing pyrimidine nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. tmpzr1t_l9r_go_relaxed.owl pyrimidine base catabolism|pyrimidine base breakdown|pyrimidine base degradation|pyrimidine base catabolic process biological_process owl:Class GO:0006206 biolink:NamedThing pyrimidine nucleobase metabolic process The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. tmpzr1t_l9r_go_relaxed.owl pyrimidine metabolic process|pyrimidine base metabolism|pyrimidine base metabolic process|pyrimidine metabolism biological_process owl:Class GO:1902081 biolink:NamedThing negative regulation of calcium ion import into sarcoplasmic reticulum Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. tmpzr1t_l9r_go_relaxed.owl inhibition of calcium ion import into sarcoplasmic reticulum|downregulation of calcium ion import into sarcoplasmic reticulum|down-regulation of calcium ion import into sarcoplasmic reticulum|down regulation of calcium ion import into sarcoplasmic reticulum rl 2013-04-24T16:07:59Z biological_process owl:Class GO:0090281 biolink:NamedThing negative regulation of calcium ion import Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. tmpzr1t_l9r_go_relaxed.owl negative regulation of transmembrane calcium influx tb 2010-02-08T05:11:20Z biological_process owl:Class GO:1900551 biolink:NamedThing N',N'',N'''-triacetylfusarinine C biosynthetic process The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C. tmpzr1t_l9r_go_relaxed.owl N',N'',N'''-triacetylfusarinine C synthesis|N',N'',N'''-triacetylfusarinine C formation|N',N'',N'''-triacetylfusarinine C biosynthesis|N',N'',N'''-triacetylfusarinine C anabolism di 2012-05-15T01:00:58Z biological_process owl:Class GO:1901566 biolink:NamedThing organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organonitrogen compound. tmpzr1t_l9r_go_relaxed.owl organonitrogen compound anabolism|organonitrogen compound formation|organonitrogen compound biosynthesis|organonitrogen compound synthesis pr 2012-11-04T15:18:00Z biological_process owl:Class GO:0032076 biolink:NamedThing negative regulation of deoxyribonuclease activity Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. tmpzr1t_l9r_go_relaxed.owl inhibition of deoxyribonuclease activity|down regulation of deoxyribonuclease activity|deoxyribonuclease inhibitor|down-regulation of deoxyribonuclease activity|downregulation of deoxyribonuclease activity|DNase inhibitor biological_process owl:Class GO:0032070 biolink:NamedThing regulation of deoxyribonuclease activity Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. tmpzr1t_l9r_go_relaxed.owl deoxyribonuclease regulator|DNase regulator biological_process owl:Class GO:0001964 biolink:NamedThing startle response An action or movement due to the application of a sudden unexpected stimulus. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Startle_reaction biological_process owl:Class GO:0009605 biolink:NamedThing response to external stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. tmpzr1t_l9r_go_relaxed.owl response to environmental stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0046611 biolink:NamedThing lysosomal proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen. tmpzr1t_l9r_go_relaxed.owl lysosomal membrane hydrogen-transporting ATPase|lysosomal hydrogen-translocating V-type ATPase complex cellular_component owl:Class GO:0016471 biolink:NamedThing vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. tmpzr1t_l9r_go_relaxed.owl vacuolar hydrogen-translocating V-type ATPase complex See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'. cellular_component owl:Class GO:1901672 biolink:NamedThing positive regulation of systemic acquired resistance Any process that activates or increases the frequency, rate or extent of systemic acquired resistance. tmpzr1t_l9r_go_relaxed.owl activation of systemic acquired resistance|upregulation of systemic acquired resistance|positive regulation of salicylic acid-dependent systemic resistance|upregulation of salicylic acid-dependent systemic resistance|up regulation of systemic acquired resistance|up-regulation of salicylic acid-dependent systemic resistance|up-regulation of systemic acquired resistance|up regulation of salicylic acid-dependent systemic resistance|activation of salicylic acid-dependent systemic resistance tb 2012-11-21T22:03:58Z biological_process owl:Class GO:0032103 biolink:NamedThing positive regulation of response to external stimulus Any process that activates, maintains or increases the rate of a response to an external stimulus. tmpzr1t_l9r_go_relaxed.owl up regulation of response to external stimulus|activation of response to external stimulus|up-regulation of response to external stimulus|stimulation of response to external stimulus|upregulation of response to external stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0060981 biolink:NamedThing cell migration involved in coronary angiogenesis The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. tmpzr1t_l9r_go_relaxed.owl dph 2009-10-06T02:49:12Z biological_process owl:Class GO:0060973 biolink:NamedThing cell migration involved in heart development The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. tmpzr1t_l9r_go_relaxed.owl dph 2009-10-06T10:53:49Z biological_process owl:Class GO:0071359 biolink:NamedThing cellular response to dsRNA Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to double-stranded RNA mah 2009-12-11T03:00:32Z biological_process owl:Class GO:0071407 biolink:NamedThing cellular response to organic cyclic compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to organic cyclic substance mah 2009-12-14T02:55:58Z biological_process owl:Class GO:0008523 biolink:NamedThing sodium-dependent multivitamin transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-199219|Reactome:R-HSA-429581|Reactome:R-HSA-199206 molecular_function owl:Class GO:0090482 biolink:NamedThing vitamin transmembrane transporter activity Enables the transfer of a vitamin from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl vitamin transporter activity|vitamin or cofactor transporter activity tb 2012-10-02T16:50:50Z GO:0051183 molecular_function owl:Class GO:0030758 biolink:NamedThing 3,7-dimethylquercitin 4'-O-methyltransferase activity Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+). tmpzr1t_l9r_go_relaxed.owl S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity|S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity|3,7-dimethylquercetin 4'-O-methyltransferase activity|flavonol 4'-methyltransferase activity|flavonol 4'-O-methyltransferase activity|4'-OMT activity RHEA:21832|KEGG_REACTION:R03456|MetaCyc:2.1.1.83-RXN|EC:2.1.1.83 molecular_function owl:Class GO:0008757 biolink:NamedThing S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. tmpzr1t_l9r_go_relaxed.owl S-adenosyl methionine-dependent methyltransferase activity|SAM-dependent methyltransferase activity molecular_function owl:Class GO:0098005 biolink:NamedThing viral head-tail joining Process by which virus heads and tails are attached to each other. tmpzr1t_l9r_go_relaxed.owl virus head-tail joining|phage head tail joining bm 2012-07-18T16:11:59Z biological_process owl:Class GO:0016032 biolink:NamedThing viral process A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. tmpzr1t_l9r_go_relaxed.owl virus process|virulence|viral infection Wikipedia:Viral_life_cycle See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'. GO:0022415 biological_process owl:Class GO:0008103 biolink:NamedThing oocyte microtubule cytoskeleton polarization Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster. tmpzr1t_l9r_go_relaxed.owl GO:0048129 biological_process owl:Class GO:0007017 biolink:NamedThing microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0031692 biolink:NamedThing alpha-1B adrenergic receptor binding Binding to an alpha-1B adrenergic receptor. tmpzr1t_l9r_go_relaxed.owl alpha-1B adrenergic receptor ligand molecular_function owl:Class GO:0031690 biolink:NamedThing adrenergic receptor binding Binding to an adrenergic receptor. tmpzr1t_l9r_go_relaxed.owl adrenergic receptor ligand molecular_function owl:Class GO:0033343 biolink:NamedThing positive regulation of collagen binding Any process that activates or increases the frequency, rate or extent of collagen binding. tmpzr1t_l9r_go_relaxed.owl up-regulation of collagen binding|activation of collagen binding|upregulation of collagen binding|stimulation of collagen binding|up regulation of collagen binding biological_process owl:Class GO:0033341 biolink:NamedThing regulation of collagen binding Any process that modulates the frequency, rate or extent of collagen binding. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1900815 biolink:NamedThing monodictyphenone biosynthetic process The chemical reactions and pathways resulting in the formation of monodictyphenone. tmpzr1t_l9r_go_relaxed.owl monodictyphenone synthesis|monodictyphenone formation|monodictyphenone anabolism|monodictyphenone biosynthesis di 2012-06-04T10:11:35Z biological_process owl:Class GO:0016053 biolink:NamedThing organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. tmpzr1t_l9r_go_relaxed.owl organic acid synthesis|organic acid biosynthesis|organic acid anabolism|organic acid formation biological_process owl:Class GO:1901173 biolink:NamedThing phytoene catabolic process The chemical reactions and pathways resulting in the breakdown of phytoene. tmpzr1t_l9r_go_relaxed.owl phytoene catabolism|phytoene breakdown|phytoene degradation yaf 2012-07-19T09:48:07Z biological_process owl:Class GO:1901172 biolink:NamedThing phytoene metabolic process The chemical reactions and pathways involving phytoene. tmpzr1t_l9r_go_relaxed.owl phytoene metabolism yaf 2012-07-19T09:47:46Z biological_process owl:Class GO:2000863 biolink:NamedThing positive regulation of estrogen secretion Any process that activates or increases the frequency, rate or extent of estrogen secretion. tmpzr1t_l9r_go_relaxed.owl positive regulation of oestrogen secretion bf 2011-07-26T08:48:31Z biological_process owl:Class GO:2000861 biolink:NamedThing regulation of estrogen secretion Any process that modulates the frequency, rate or extent of estrogen secretion. tmpzr1t_l9r_go_relaxed.owl regulation of oestrogen secretion bf 2011-07-26T08:48:24Z biological_process owl:Class GO:0045115 biolink:NamedThing regulation of beta 2 integrin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. tmpzr1t_l9r_go_relaxed.owl regulation of beta 2 integrin synthesis|regulation of beta 2 integrin anabolism|regulation of beta 2 integrin biosynthesis|regulation of beta 2 integrin formation biological_process owl:Class GO:0008187 biolink:NamedThing poly-pyrimidine tract binding Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0003727 biolink:NamedThing single-stranded RNA binding Binding to single-stranded RNA. tmpzr1t_l9r_go_relaxed.owl ssRNA binding GO:0003728 molecular_function owl:Class GO:0030656 biolink:NamedThing regulation of vitamin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. tmpzr1t_l9r_go_relaxed.owl regulation of vitamin metabolism biological_process owl:Class GO:0061708 biolink:NamedThing tRNA-5-taurinomethyluridine 2-sulfurtransferase Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+. tmpzr1t_l9r_go_relaxed.owl RHEA:47040|Reactome:R-HSA-6787447|MetaCyc:RXN-16821 dph 2015-06-16T09:02:23Z molecular_function owl:Class GO:0016783 biolink:NamedThing sulfurtransferase activity Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). tmpzr1t_l9r_go_relaxed.owl tRNA sulfurtransferase activity|sulphurtransferase activity Reactome:R-HSA-6782264|EC:2.8.1.-|Reactome:R-HSA-947538|Reactome:R-HSA-1614618 molecular_function owl:Class GO:1900149 biolink:NamedThing positive regulation of Schwann cell migration Any process that activates or increases the frequency, rate or extent of Schwann cell migration. tmpzr1t_l9r_go_relaxed.owl upregulation of Schwann cell migration|up-regulation of Schwann cell migration|activation of Schwann cell migration|up regulation of Schwann cell migration bf 2012-03-06T04:14:58Z biological_process owl:Class GO:1900147 biolink:NamedThing regulation of Schwann cell migration Any process that modulates the frequency, rate or extent of Schwann cell migration. tmpzr1t_l9r_go_relaxed.owl bf 2012-03-06T04:14:50Z biological_process owl:Class GO:1904881 biolink:NamedThing cellular response to hydrogen sulfide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to sulfane|cellular response to dihydridosulfur sl 2016-01-04T23:56:35Z biological_process owl:Class GO:0070887 biolink:NamedThing cellular response to chemical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. tmpzr1t_l9r_go_relaxed.owl Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. mah 2009-08-27T04:41:45Z biological_process owl:Class GO:2000850 biolink:NamedThing negative regulation of glucocorticoid secretion Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion. tmpzr1t_l9r_go_relaxed.owl bf 2011-07-26T08:44:48Z biological_process owl:Class GO:1900553 biolink:NamedThing asperfuranone catabolic process The chemical reactions and pathways resulting in the breakdown of asperfuranone. tmpzr1t_l9r_go_relaxed.owl asperfuranone degradation|asperfuranone breakdown|asperfuranone catabolism di 2012-05-15T01:31:35Z biological_process owl:Class GO:1901361 biolink:NamedThing organic cyclic compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. tmpzr1t_l9r_go_relaxed.owl organic cyclic compound breakdown|organic cyclic compound catabolism|organic cyclic compound degradation bf 2012-09-14T09:05:04Z biological_process owl:Class GO:0014733 biolink:NamedThing regulation of skeletal muscle adaptation Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. tmpzr1t_l9r_go_relaxed.owl regulation of skeletal muscle plasticity biological_process owl:Class GO:0072184 biolink:NamedThing renal vesicle progenitor cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing. tmpzr1t_l9r_go_relaxed.owl mah 2010-02-26T02:52:54Z biological_process owl:Class GO:0061005 biolink:NamedThing cell differentiation involved in kidney development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. tmpzr1t_l9r_go_relaxed.owl dph 2010-01-21T09:13:55Z biological_process owl:Class GO:1905086 biolink:NamedThing negative regulation of bioluminescence Any process that stops, prevents or reduces the frequency, rate or extent of bioluminescence. tmpzr1t_l9r_go_relaxed.owl down regulation of bioluminescence|down-regulation of bioluminescence|downregulation of bioluminescence|inhibition of bioluminescence rph 2016-03-29T07:51:17Z biological_process owl:Class GO:0031324 biolink:NamedThing negative regulation of cellular metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. tmpzr1t_l9r_go_relaxed.owl down regulation of cellular metabolic process|down-regulation of cellular metabolic process|downregulation of cellular metabolic process|inhibition of cellular metabolic process|negative regulation of cellular metabolism biological_process owl:Class GO:0018212 biolink:NamedThing peptidyl-tyrosine modification The modification of peptidyl-tyrosine. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0018193 biolink:NamedThing peptidyl-amino acid modification The alteration of an amino acid residue in a peptide. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0055019 biolink:NamedThing negative regulation of cardiac muscle fiber development Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. tmpzr1t_l9r_go_relaxed.owl inhibition of cardiac muscle fiber development|negative regulation of heart muscle fiber development|negative regulation of cardiac muscle fibre development|downregulation of cardiac muscle fiber development|down-regulation of cardiac muscle fiber development|down regulation of cardiac muscle fiber development biological_process owl:Class GO:0055018 biolink:NamedThing regulation of cardiac muscle fiber development Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. tmpzr1t_l9r_go_relaxed.owl regulation of heart muscle fiber development|regulation of cardiac muscle fibre development biological_process owl:Class GO:0000978 biolink:NamedThing RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. tmpzr1t_l9r_go_relaxed.owl RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II promoter proximal region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to cis-regulatory sequences. In bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is usually a synonym for "enhancer". krc 2010-08-10T02:17:19Z GO:0000980 molecular_function owl:Class GO:0000987 biolink:NamedThing cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter. tmpzr1t_l9r_go_relaxed.owl bacterial-type RNA polymerase enhancer sequence-specific DNA binding|proximal promoter sequence-specific DNA binding|bacterial-type proximal promoter sequence-specific DNA binding|eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding|core promoter proximal region DNA binding|bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding|cis-regulatory region binding|promoter proximal region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|bacterial-type cis-regulatory region sequence-specific DNA binding|enhancer sequence-specific DNA binding|bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding|enhancer binding bf 2010-02-26T10:17:00Z GO:0001150|GO:0000986|GO:0001158|GO:0001159|GO:0035326 molecular_function owl:Class GO:1905698 biolink:NamedThing positive regulation of polysome binding Any process that activates or increases the frequency, rate or extent of polysome binding. tmpzr1t_l9r_go_relaxed.owl activation of polyribosome binding|up-regulation of polyribosome binding|up regulation of polysome binding|up-regulation of polysome binding|upregulation of polyribosome binding|positive regulation of polyribosome binding|activation of polysome binding|upregulation of polysome binding|up regulation of polyribosome binding bc 2016-11-14T23:26:37Z biological_process owl:Class GO:1905696 biolink:NamedThing regulation of polysome binding Any process that modulates the frequency, rate or extent of polysome binding. tmpzr1t_l9r_go_relaxed.owl regulation of polyribosome binding bc 2016-11-14T23:26:22Z biological_process owl:Class GO:1990611 biolink:NamedThing regulation of cytoplasmic translational initiation in response to stress Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). tmpzr1t_l9r_go_relaxed.owl vw 2015-01-20T13:04:14Z biological_process owl:Class GO:1990497 biolink:NamedThing regulation of cytoplasmic translation in response to stress Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). tmpzr1t_l9r_go_relaxed.owl vw 2014-09-26T11:11:29Z biological_process owl:Class GO:0003251 biolink:NamedThing positive regulation of cell proliferation involved in heart valve morphogenesis Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve. tmpzr1t_l9r_go_relaxed.owl dph 2009-10-13T02:07:20Z biological_process owl:Class GO:1904869 biolink:NamedThing regulation of protein localization to Cajal body Any process that modulates the frequency, rate or extent of protein localization to Cajal body. tmpzr1t_l9r_go_relaxed.owl regulation of protein localisation to Cajal body|regulation of protein localisation in Cajal body|regulation of protein localization in Cajal body nc 2015-12-18T11:17:31Z biological_process owl:Class GO:1900180 biolink:NamedThing regulation of protein localization to nucleus Any process that modulates the frequency, rate or extent of protein localization to nucleus. tmpzr1t_l9r_go_relaxed.owl regulation of protein localization in cell nucleus|regulation of protein localization in nucleus|regulation of protein localisation to nucleus bf 2012-03-12T01:23:44Z biological_process owl:Class GO:0047100 biolink:NamedThing glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate. tmpzr1t_l9r_go_relaxed.owl NADP-dependent glyceraldehyde phosphate dehydrogenase activity|triosephosphate dehydrogenase (NADP+) activity|triosephosphate dehydrogenase (NADP(+)) activity|glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)|triosephosphate dehydrogenase (NADP)|NADP-triose phosphate dehydrogenase activity|dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)|D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)|NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity EC:1.2.1.13|RHEA:10296|MetaCyc:1.2.1.13-RXN molecular_function owl:Class GO:0043891 biolink:NamedThing glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+. tmpzr1t_l9r_go_relaxed.owl glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)|NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity|triosephosphate dehydrogenase (NAD(P))|D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)|triosephosphate dehydrogenase (NAD(P)+) MetaCyc:GAPDHSYNEC-RXN|EC:1.2.1.59 molecular_function owl:Class GO:0072227 biolink:NamedThing metanephric macula densa development The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus. tmpzr1t_l9r_go_relaxed.owl mah 2010-03-18T03:37:26Z biological_process owl:Class GO:0072024 biolink:NamedThing macula densa development The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus. tmpzr1t_l9r_go_relaxed.owl mah 2010-01-25T02:40:15Z biological_process owl:Class GO:0060757 biolink:NamedThing adult foraging behavior Behavior by which an adult locates food. tmpzr1t_l9r_go_relaxed.owl dph 2009-06-22T02:50:56Z biological_process owl:Class GO:0060756 biolink:NamedThing foraging behavior Behavior by which an organism locates food. tmpzr1t_l9r_go_relaxed.owl dph 2009-06-22T02:46:25Z biological_process owl:Class GO:0106397 biolink:NamedThing positive regulation of R7 cell fate commitment Any process that activates or increases the frequency, rate or extent of R7 cell fate commitment. tmpzr1t_l9r_go_relaxed.owl hjd 2021-10-08T19:14:40Z biological_process owl:Class GO:0010455 biolink:NamedThing positive regulation of cell fate commitment Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0033244 biolink:NamedThing regulation of penicillin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. tmpzr1t_l9r_go_relaxed.owl regulation of penicillin metabolism biological_process owl:Class GO:0034248 biolink:NamedThing regulation of cellular amide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. tmpzr1t_l9r_go_relaxed.owl regulation of amide metabolism biological_process owl:Class GO:0043480 biolink:NamedThing pigment accumulation in tissues The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus. tmpzr1t_l9r_go_relaxed.owl organismal pigment accumulation biological_process owl:Class GO:0032501 biolink:NamedThing multicellular organismal process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. tmpzr1t_l9r_go_relaxed.owl single-multicellular organism process|organismal physiological process jl 2012-09-19T16:07:47Z GO:0050874|GO:0044707 biological_process owl:Class GO:0031969 biolink:NamedThing chloroplast membrane Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Chloroplast_membrane cellular_component owl:Class GO:0042170 biolink:NamedThing plastid membrane Either of the lipid bilayers that surround a plastid and form the plastid envelope. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0051321 biolink:NamedThing meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. tmpzr1t_l9r_go_relaxed.owl meiosis Wikipedia:Meiosis Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. GO:0007126 biological_process owl:Class GO:0022414 biolink:NamedThing reproductive process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. tmpzr1t_l9r_go_relaxed.owl single organism reproductive process jl 2012-09-19T15:56:06Z GO:0044702 biological_process owl:Class GO:0021552 biolink:NamedThing midbrain-hindbrain boundary structural organization The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. tmpzr1t_l9r_go_relaxed.owl midbrain-hindbrain boundary structural organisation|isthmus structural organization|MHB structural organization biological_process owl:Class GO:0048532 biolink:NamedThing anatomical structure arrangement The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. tmpzr1t_l9r_go_relaxed.owl organization of an anatomical structure|structural organization|anatomical structure organization|anatomical structure structural organization biological_process owl:Class GO:1903343 biolink:NamedThing positive regulation of meiotic DNA double-strand break formation Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation. tmpzr1t_l9r_go_relaxed.owl activation of meiotic DNA double-strand break formation|upregulation of meiotic DNA double-strand break formation|up regulation of meiotic DNA double-strand break formation|up-regulation of meiotic DNA double-strand break formation mcc 2014-08-18T21:32:11Z biological_process owl:Class GO:0045935 biolink:NamedThing positive regulation of nucleobase-containing compound metabolic process Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. tmpzr1t_l9r_go_relaxed.owl positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism|upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process biological_process owl:Class GO:2001102 biolink:NamedThing hexasaccharide transport The directed movement of a hexasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl jl 2011-09-21T02:20:31Z biological_process owl:Class GO:0015772 biolink:NamedThing oligosaccharide transport The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0061669 biolink:NamedThing spontaneous neurotransmitter secretion Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential. tmpzr1t_l9r_go_relaxed.owl stimulus-independent neurotransmitter secretion dph 2014-11-17T07:52:35Z biological_process owl:Class GO:0007269 biolink:NamedThing neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. tmpzr1t_l9r_go_relaxed.owl neurotransmitter release|neurotransmitter secretory pathway A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. GO:0010554 biological_process owl:Class GO:2000335 biolink:NamedThing regulation of endothelial microparticle formation Any process that modulates the frequency, rate or extent of endothelial microparticle formation. tmpzr1t_l9r_go_relaxed.owl regulation of endothelial microparticle generation|regulation of endothelial microparticle release mah 2011-01-31T11:20:26Z biological_process owl:Class GO:0071616 biolink:NamedThing acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. tmpzr1t_l9r_go_relaxed.owl acyl-CoA synthesis|acyl-CoA biosynthesis|acyl-CoA formation|acyl-CoA anabolism mah 2010-02-08T04:43:31Z biological_process owl:Class GO:0006637 biolink:NamedThing acyl-CoA metabolic process The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. tmpzr1t_l9r_go_relaxed.owl acyl-CoA metabolism biological_process owl:Class GO:0055044 biolink:NamedThing symplast The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Symplast cellular_component owl:Class GO:0110165 biolink:NamedThing cellular anatomical entity A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. tmpzr1t_l9r_go_relaxed.owl kmv 2019-08-12T18:01:37Z cellular_component owl:Class GO:0033497 biolink:NamedThing sinapate biosynthetic process The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate. tmpzr1t_l9r_go_relaxed.owl sinapate biosynthesis|sinapate formation|sinapate synthesis|sinapate anabolism MetaCyc:PWY-5168 biological_process owl:Class GO:0072330 biolink:NamedThing monocarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. tmpzr1t_l9r_go_relaxed.owl monocarboxylic acid synthesis|monocarboxylic acid biosynthesis|monocarboxylic acid formation|monocarboxylic acid anabolism mah 2010-11-02T04:51:32Z biological_process owl:Class GO:0030955 biolink:NamedThing potassium ion binding Binding to a potassium ion (K+). tmpzr1t_l9r_go_relaxed.owl K ion binding molecular_function owl:Class GO:0031420 biolink:NamedThing alkali metal ion binding Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0045723 biolink:NamedThing positive regulation of fatty acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. tmpzr1t_l9r_go_relaxed.owl positive regulation of fatty acid biosynthesis|activation of fatty acid biosynthetic process|up regulation of fatty acid biosynthetic process|positive regulation of fatty acid formation|up-regulation of fatty acid biosynthetic process|positive regulation of fatty acid synthesis|upregulation of fatty acid biosynthetic process|positive regulation of fatty acid anabolism|stimulation of fatty acid biosynthetic process biological_process owl:Class GO:0045923 biolink:NamedThing positive regulation of fatty acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. tmpzr1t_l9r_go_relaxed.owl positive regulation of fatty acid metabolism|activation of fatty acid metabolic process|upregulation of fatty acid metabolic process|up regulation of fatty acid metabolic process|up-regulation of fatty acid metabolic process|stimulation of fatty acid metabolic process biological_process owl:Class GO:0045949 biolink:NamedThing positive regulation of phosphorus utilization Any process that activates or increases the frequency, rate or extent of phosphorus utilization. tmpzr1t_l9r_go_relaxed.owl up-regulation of phosphorus utilization|up regulation of phosphorus utilization|stimulation of phosphorus utilization|upregulation of phosphorus utilization|activation of phosphorus utilization biological_process owl:Class GO:0002223 biolink:NamedThing stimulatory C-type lectin receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation. tmpzr1t_l9r_go_relaxed.owl stimulatory C-type lectin receptor signalling pathway|stimulatory Ly49 family receptor signaling pathway biological_process owl:Class GO:0002220 biolink:NamedThing innate immune response activating cell surface receptor signaling pathway Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor. tmpzr1t_l9r_go_relaxed.owl innate immune response activating cell surface receptor signalling pathway|activation of innate immune response by cell surface receptor signaling pathway biological_process owl:Class GO:1900270 biolink:NamedThing positive regulation of reverse transcription Any process that activates or increases the frequency, rate or extent of reverse transcription. tmpzr1t_l9r_go_relaxed.owl activation of reverse transcription|upregulation of reverse transcription|up-regulation of reverse transcription|up regulation of reverse transcription tb 2012-04-03T11:13:43Z biological_process owl:Class GO:1900268 biolink:NamedThing regulation of reverse transcription Any process that modulates the frequency, rate or extent of reverse transcription. tmpzr1t_l9r_go_relaxed.owl tb 2012-04-03T11:13:26Z biological_process owl:Class GO:1901300 biolink:NamedThing positive regulation of hydrogen peroxide-mediated programmed cell death Any process that activates or increases the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death. tmpzr1t_l9r_go_relaxed.owl activation of hydrogen peroxide-mediated programmed cell death|upregulation of hydrogen peroxide-mediated programmed cell death|up regulation of hydrogen peroxide-mediated programmed cell death|up-regulation of hydrogen peroxide-mediated programmed cell death vk 2012-08-21T09:45:29Z biological_process owl:Class GO:0043068 biolink:NamedThing positive regulation of programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. tmpzr1t_l9r_go_relaxed.owl activation of programmed cell death|stimulation of programmed cell death|upregulation of programmed cell death|up-regulation of programmed cell death|up regulation of programmed cell death|positive regulation of non-apoptotic programmed cell death GO:0043071 biological_process owl:Class GO:0009505 biolink:NamedThing plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. tmpzr1t_l9r_go_relaxed.owl cellulose and pectin-containing cell wall|plant cell wall cellular_component owl:Class GO:0005618 biolink:NamedThing cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/21669 Wikipedia:Cell_wall Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995). cellular_component owl:Class GO:0009710 biolink:NamedThing tropane alkaloid biosynthetic process The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system. tmpzr1t_l9r_go_relaxed.owl tropane alkaloid anabolism|tropane alkaloid biosynthesis|tropane alkaloid synthesis|tropane alkaloid formation biological_process owl:Class GO:1901362 biolink:NamedThing organic cyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic cyclic compound. tmpzr1t_l9r_go_relaxed.owl organic cyclic compound biosynthesis|organic cyclic compound formation|organic cyclic compound anabolism|organic cyclic compound synthesis bf 2012-09-14T09:05:22Z biological_process owl:Class GO:0045836 biolink:NamedThing positive regulation of meiotic nuclear division Any process that activates or increases the frequency, rate or extent of meiosis. tmpzr1t_l9r_go_relaxed.owl up-regulation of meiosis|stimulation of meiosis|activation of meiosis|upregulation of meiosis|positive regulation of meiosis|up regulation of meiosis biological_process owl:Class GO:0051446 biolink:NamedThing positive regulation of meiotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. tmpzr1t_l9r_go_relaxed.owl upregulation of progression through meiotic cell cycle|stimulation of progression through meiotic cell cycle|positive regulation of progression through meiotic cell cycle|positive regulation of meiotic cell cycle progression|activation of progression through meiotic cell cycle|up regulation of progression through meiotic cell cycle|up-regulation of progression through meiotic cell cycle biological_process owl:Class GO:0060668 biolink:NamedThing regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland. tmpzr1t_l9r_go_relaxed.owl regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalling dph 2009-06-01T09:47:56Z biological_process owl:Class GO:0060693 biolink:NamedThing regulation of branching involved in salivary gland morphogenesis Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium. tmpzr1t_l9r_go_relaxed.owl dph 2009-06-08T01:14:44Z biological_process owl:Class GO:0019460 biolink:NamedThing glutamine catabolic process to fumarate The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate. tmpzr1t_l9r_go_relaxed.owl glutamine breakdown to fumarate|glutamine degradation to fumarate|glutamate catabolic process to fumarate biological_process owl:Class GO:0006543 biolink:NamedThing glutamine catabolic process The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid. tmpzr1t_l9r_go_relaxed.owl glutamine catabolism|glutamine breakdown|glutamine degradation biological_process owl:Class GO:0062091 biolink:NamedThing Ycf2/FtsHi complex A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma. tmpzr1t_l9r_go_relaxed.owl TIC complex associated chloroplast protein import motor dph 2018-11-08T20:06:11Z cellular_component owl:Class GO:1904949 biolink:NamedThing ATPase complex A protein complex which is capable of ATPase activity. tmpzr1t_l9r_go_relaxed.owl VPS4 complex An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay). bhm 2016-02-04T22:13:32Z cellular_component owl:Class GO:0007131 biolink:NamedThing reciprocal meiotic recombination The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. tmpzr1t_l9r_go_relaxed.owl gene conversion with reciprocal crossover|female meiotic recombination GO:0007145|GO:0000021 biological_process owl:Class GO:0140527 biolink:NamedThing reciprocal homologous recombination A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/18777 pg 2020-09-29T15:08:11Z biological_process owl:Class GO:0019510 biolink:NamedThing S-adenosylhomocysteine catabolic process The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine. tmpzr1t_l9r_go_relaxed.owl S-adenosylhomocysteine breakdown|S-adenosylhomocysteine catabolism|S-adenosylhomocysteine degradation MetaCyc:ADENOSYLHOMOCYSCAT-PWY biological_process owl:Class GO:0042219 biolink:NamedThing cellular modified amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. tmpzr1t_l9r_go_relaxed.owl cellular modified amino acid degradation|cellular modified amino acid catabolism|cellular amino acid derivative degradation|amino acid derivative catabolic process|cellular amino acid derivative breakdown|cellular amino acid derivative catabolic process|modified amino acid catabolism|modified amino acid catabolic process|cellular amino acid derivative catabolism|cellular modified amino acid breakdown biological_process owl:Class GO:0110045 biolink:NamedThing negative regulation of cell cycle switching, mitotic to meiotic cell cycle Any process that stops, prevents, or reduces the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division. tmpzr1t_l9r_go_relaxed.owl kmv 2017-08-08T21:33:28Z biological_process owl:Class GO:0110044 biolink:NamedThing regulation of cell cycle switching, mitotic to meiotic cell cycle Any process that modulates the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division. tmpzr1t_l9r_go_relaxed.owl sexual differentiation https://github.com/geneontology/go-ontology/issues/20926 kmv 2017-08-08T21:24:45Z biological_process owl:Class GO:0120022 biolink:NamedThing glucagon family peptide binding Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP). tmpzr1t_l9r_go_relaxed.owl glucagon-like peptide binding|glucagon binding https://github.com/geneontology/go-ontology/issues/13143|https://github.com/geneontology/go-ontology/issues/21327 krc 2017-03-17T14:46:29Z GO:0120024 molecular_function owl:Class GO:0017046 biolink:NamedThing peptide hormone binding Binding to a peptide with hormonal activity in animals. tmpzr1t_l9r_go_relaxed.owl polypeptide hormone binding molecular_function owl:Class GO:0090153 biolink:NamedThing regulation of sphingolipid biosynthetic process Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). tmpzr1t_l9r_go_relaxed.owl tb 2009-12-08T03:25:49Z biological_process owl:Class GO:0051171 biolink:NamedThing regulation of nitrogen compound metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. tmpzr1t_l9r_go_relaxed.owl regulation of nitrogen metabolic process|regulation of nitrogen metabolism biological_process owl:Class GO:0019912 biolink:NamedThing cyclin-dependent protein kinase activating kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK). tmpzr1t_l9r_go_relaxed.owl cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity|cdk-activating kinase activity|CAK GO:0019913 molecular_function owl:Class GO:0030295 biolink:NamedThing protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:1905465 biolink:NamedThing regulation of G-quadruplex DNA unwinding Any process that modulates the frequency, rate or extent of G-quadruplex DNA unwinding. tmpzr1t_l9r_go_relaxed.owl ans 2016-09-19T12:15:45Z biological_process owl:Class GO:0120261 biolink:NamedThing regulation of heterochromatin organization Any process that modulates the frequency, rate, extent or location of heterochromatin organization. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/20020 krc 2020-09-29T20:00:04Z biological_process owl:Class GO:1902275 biolink:NamedThing regulation of chromatin organization Any process that modulates the frequency, rate or extent of chromatin organization. tmpzr1t_l9r_go_relaxed.owl regulation of chromatin modification|regulation of chromatin organisation|regulation of establishment or maintenance of chromatin architecture bf 2013-07-01T13:21:52Z GO:1903308 biological_process owl:Class GO:0000939 biolink:NamedThing inner kinetochore The region of a kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome. tmpzr1t_l9r_go_relaxed.owl condensed nuclear chromosome inner kinetochore|inner kinetochore of condensed chromosome|inner kinetochore of condensed nuclear chromosome|condensed chromosome inner kinetochore|inner centromere core complex|inner kinetochore plate https://github.com/geneontology/go-ontology/issues/21126 GO:0000941 cellular_component owl:Class GO:0002763 biolink:NamedThing positive regulation of myeloid leukocyte differentiation Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. tmpzr1t_l9r_go_relaxed.owl upregulation of myeloid leukocyte differentiation|up regulation of myeloid leukocyte differentiation|up-regulation of myeloid leukocyte differentiation|activation of myeloid leukocyte differentiation|stimulation of myeloid leukocyte differentiation biological_process owl:Class GO:0045639 biolink:NamedThing positive regulation of myeloid cell differentiation Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. tmpzr1t_l9r_go_relaxed.owl up regulation of myeloid cell differentiation|upregulation of myeloid cell differentiation|stimulation of myeloid cell differentiation|up-regulation of myeloid cell differentiation|activation of myeloid cell differentiation biological_process owl:Class GO:0002431 biolink:NamedThing Fc receptor mediated stimulatory signaling pathway A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. tmpzr1t_l9r_go_relaxed.owl Fc receptor mediated stimulatory signalling pathway|Fc-receptor mediated stimulatory signaling pathway biological_process owl:Class GO:0002429 biolink:NamedThing immune response-activating cell surface receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response. tmpzr1t_l9r_go_relaxed.owl activation of immune response by cell surface receptor signaling pathway|immune response-activating cell surface receptor signalling pathway biological_process owl:Class GO:0052802 biolink:NamedThing nitroimidazole metabolic process The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring. tmpzr1t_l9r_go_relaxed.owl nitroimidazole metabolism biological_process owl:Class GO:0052803 biolink:NamedThing imidazole-containing compound metabolic process The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. tmpzr1t_l9r_go_relaxed.owl imidazole metabolism biological_process owl:Class GO:0043388 biolink:NamedThing positive regulation of DNA binding Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). tmpzr1t_l9r_go_relaxed.owl stimulation of DNA binding|upregulation of DNA binding|up regulation of DNA binding|up-regulation of DNA binding|activation of DNA binding biological_process owl:Class GO:0051101 biolink:NamedThing regulation of DNA binding Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1901886 biolink:NamedThing 2-hydroxybenzoyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of 2-hydroxybenzoyl-CoA. tmpzr1t_l9r_go_relaxed.owl 2-hydroxybenzoyl-CoA catabolism|2-hydroxybenzoyl-CoA degradation|2-hydroxybenzoyl-CoA breakdown ms 2013-02-06T14:06:08Z biological_process owl:Class GO:0019336 biolink:NamedThing phenol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. tmpzr1t_l9r_go_relaxed.owl phenol-containing compound breakdown|phenol-containing compound catabolism|phenol-containing compound degradation MetaCyc:PHENOLDEG-PWY biological_process owl:Class GO:0019498 biolink:NamedThing n-octane oxidation The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA. tmpzr1t_l9r_go_relaxed.owl MetaCyc:P221-PWY biological_process owl:Class GO:0018939 biolink:NamedThing n-octane metabolic process The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System. tmpzr1t_l9r_go_relaxed.owl n-octane metabolism UM-BBD_pathwayID:oct biological_process owl:Class GO:1902461 biolink:NamedThing negative regulation of mesenchymal stem cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell proliferation. tmpzr1t_l9r_go_relaxed.owl downregulation of mesenchymal stem cell proliferation|down regulation of mesenchymal stem cell proliferation|down regulation of MSC proliferation|negative regulation of MSC proliferation|inhibition of mesenchymal stem cell proliferation|downregulation of MSC proliferation|down-regulation of mesenchymal stem cell proliferation|down-regulation of MSC proliferation|inhibition of MSC proliferation pm 2013-10-22T10:01:08Z biological_process owl:Class GO:2000987 biolink:NamedThing positive regulation of behavioral fear response Any process that activates or increases the frequency, rate or extent of behavioral fear response. tmpzr1t_l9r_go_relaxed.owl positive regulation of behavioural fear response yaf 2011-08-08T09:16:39Z biological_process owl:Class GO:1901349 biolink:NamedThing glucosinolate transport The directed movement of a glucosinolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl tb 2012-09-07T22:44:34Z biological_process owl:Class GO:0072348 biolink:NamedThing sulfur compound transport The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl sulfur-containing compound transport mah 2010-11-11T11:43:56Z biological_process owl:Class GO:1900784 biolink:NamedThing fumiquinazoline F biosynthetic process The chemical reactions and pathways resulting in the formation of fumiquinazoline F. tmpzr1t_l9r_go_relaxed.owl fumiquinazoline F anabolism|fumiquinazoline F formation|fumiquinazoline F synthesis|fumiquinazoline F biosynthesis di 2012-06-04T09:31:34Z biological_process owl:Class GO:0042435 biolink:NamedThing indole-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. tmpzr1t_l9r_go_relaxed.owl indole derivative biosynthetic process|indole-containing compound synthesis|indole-containing compound biosynthesis|indole-containing compound anabolism|indole derivative biosynthesis|indole-containing compound formation biological_process owl:Class GO:0046859 biolink:NamedThing hydrogenosomal membrane The lipid bilayer surrounding a hydrogenosome. tmpzr1t_l9r_go_relaxed.owl hydrogenosome membrane cellular_component owl:Class GO:0098588 biolink:NamedThing bounding membrane of organelle The lipid bilayer that forms the outer-most layer of an organelle. tmpzr1t_l9r_go_relaxed.owl Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. dos 2014-02-26T13:41:31Z cellular_component owl:Class GO:0048575 biolink:NamedThing short-day photoperiodism, flowering A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length. tmpzr1t_l9r_go_relaxed.owl short-day photoperiodic control of flowering time|short-day photoperiodic control of flowering|response to long-night, flowering|short-day photoperiodic control of inflorescence development|long-night photoperiodism, flowering|response to short-day, flowering biological_process owl:Class GO:0048573 biolink:NamedThing photoperiodism, flowering A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species. tmpzr1t_l9r_go_relaxed.owl photoperiodic control of flowering time|response to night length, flowering|photoperiodic control of inflorescence development|response to photoperiod, flowering|response to day length, flowering biological_process owl:Class GO:1902697 biolink:NamedThing valine catabolic process to isobutanol The chemical reactions and pathways resulting in the breakdown of valine to isobutanol. tmpzr1t_l9r_go_relaxed.owl valine catabolism to isobutanol|valine degradation to isobutanol|valine breakdown to isobutanol tb 2014-02-19T18:28:19Z GO:1990292 biological_process owl:Class GO:0006574 biolink:NamedThing valine catabolic process The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid. tmpzr1t_l9r_go_relaxed.owl valine breakdown|valine catabolism|valine degradation MetaCyc:VALDEG-PWY biological_process owl:Class GO:1901465 biolink:NamedThing positive regulation of tetrapyrrole biosynthetic process Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process. tmpzr1t_l9r_go_relaxed.owl up regulation of tetrapyrrole formation|positive regulation of tetrapyrrole formation|positive regulation of tetrapyrrole anabolism|up regulation of tetrapyrrole biosynthetic process|up-regulation of tetrapyrrole biosynthesis|up-regulation of tetrapyrrole formation|upregulation of tetrapyrrole biosynthetic process|positive regulation of tetrapyrrole synthesis|up regulation of tetrapyrrole synthesis|activation of tetrapyrrole biosynthetic process|up-regulation of tetrapyrrole synthesis|up regulation of tetrapyrrole biosynthesis|upregulation of tetrapyrrole formation|upregulation of tetrapyrrole biosynthesis|up-regulation of tetrapyrrole biosynthetic process|positive regulation of tetrapyrrole biosynthesis|activation of tetrapyrrole biosynthesis|up-regulation of tetrapyrrole anabolism|activation of tetrapyrrole synthesis|upregulation of tetrapyrrole synthesis|activation of tetrapyrrole formation|activation of tetrapyrrole anabolism|up regulation of tetrapyrrole anabolism|upregulation of tetrapyrrole anabolism tt 2012-10-02T14:35:43Z biological_process owl:Class GO:0031328 biolink:NamedThing positive regulation of cellular biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl positive regulation of cellular biosynthesis|upregulation of cellular biosynthetic process|positive regulation of cellular anabolism|up-regulation of cellular biosynthetic process|activation of cellular biosynthetic process|up regulation of cellular biosynthetic process|positive regulation of cellular synthesis|stimulation of cellular biosynthetic process|positive regulation of cellular formation biological_process owl:Class GO:0008614 biolink:NamedThing pyridoxine metabolic process The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. tmpzr1t_l9r_go_relaxed.owl pyridoxine metabolism GO:0006773 biological_process owl:Class GO:1901615 biolink:NamedThing organic hydroxy compound metabolic process The chemical reactions and pathways involving organic hydroxy compound. tmpzr1t_l9r_go_relaxed.owl organic hydroxy compound metabolism pr 2012-11-13T12:54:27Z biological_process owl:Class GO:0060280 biolink:NamedThing negative regulation of ovulation Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0043915 biolink:NamedThing L-seryl-tRNA(Sec) kinase activity Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec). tmpzr1t_l9r_go_relaxed.owl O-phosphoseryl-tRNA(Sec) kinase activity MetaCyc:RXN-10038|EC:2.7.1.164|RHEA:25037 molecular_function owl:Class GO:0140101 biolink:NamedThing catalytic activity, acting on a tRNA Catalytic activity that acts to modify a tRNA. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-15T18:41:41Z molecular_function owl:Class GO:0036138 biolink:NamedThing peptidyl-histidine hydroxylation The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine. tmpzr1t_l9r_go_relaxed.owl bf 2012-03-07T09:25:25Z biological_process owl:Class GO:0018202 biolink:NamedThing peptidyl-histidine modification The modification of peptidyl-histidine. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0060760 biolink:NamedThing positive regulation of response to cytokine stimulus Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. tmpzr1t_l9r_go_relaxed.owl dph 2009-06-22T02:58:04Z biological_process owl:Class GO:0048584 biolink:NamedThing positive regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. tmpzr1t_l9r_go_relaxed.owl up regulation of response to stimulus|activation of response to stimulus|stimulation of response to stimulus|up-regulation of response to stimulus|upregulation of response to stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0044630 biolink:NamedThing modulation of complement activation, lectin pathway in other organism A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism. tmpzr1t_l9r_go_relaxed.owl regulation of complement activation, lectin pathway in other organism jl 2012-07-05T01:10:31Z biological_process owl:Class GO:0044645 biolink:NamedThing modulation of complement activation in other organism A process that modulates the frequency, rate or extent of complement activation in a different organism. tmpzr1t_l9r_go_relaxed.owl regulation of complement activation in other organism jl 2012-07-11T12:37:50Z biological_process owl:Class GO:1900229 biolink:NamedThing negative regulation of single-species biofilm formation in or on host organism Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism. tmpzr1t_l9r_go_relaxed.owl down regulation of single-species biofilm formation in or on host organism|downregulation of single-species biofilm formation in or on host organism|down-regulation of single-species biofilm formation in or on host organism|inhibition of single-species biofilm formation in or on host organism di 2012-03-23T04:37:05Z biological_process owl:Class GO:1900228 biolink:NamedThing regulation of single-species biofilm formation in or on host organism Any process that modulates the frequency, rate or extent of single-species biofilm formation in or on host organism. tmpzr1t_l9r_go_relaxed.owl di 2012-03-23T04:36:54Z biological_process owl:Class GO:0032301 biolink:NamedThing MutSalpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6. tmpzr1t_l9r_go_relaxed.owl MSH2/MSH6 complex|MMR complex cellular_component owl:Class GO:0140513 biolink:NamedThing nuclear protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. tmpzr1t_l9r_go_relaxed.owl nuclear complex pg 2020-09-09T05:12:38Z cellular_component owl:Class GO:1903779 biolink:NamedThing regulation of cardiac conduction Any process that modulates the frequency, rate or extent of cardiac conduction. tmpzr1t_l9r_go_relaxed.owl rph 2015-01-07T13:20:11Z biological_process owl:Class GO:1900968 biolink:NamedThing regulation of sarcinapterin metabolic process Any process that modulates the frequency, rate or extent of sarcinapterin metabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of sarcinapterin metabolism tt 2012-06-14T03:58:11Z biological_process owl:Class GO:0062012 biolink:NamedThing regulation of small molecule metabolic process Any process that modulates the rate, frequency or extent of a small molecule metabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of small molecule metabolism dph 2018-03-19T14:11:54Z biological_process owl:Class GO:1902636 biolink:NamedThing kinociliary basal body A ciliary basal body that is part of a kinocilium. tmpzr1t_l9r_go_relaxed.owl cilial basal body of kinocilium|kinocilium ciliary basal body|ciliary basal body of kinocilium|microtubule basal body of kinocilium|cilium basal body of kinocilium|kinocilium basal body|kinocilial basal body pr 2014-01-20T13:48:45Z cellular_component owl:Class GO:0036064 biolink:NamedThing ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. tmpzr1t_l9r_go_relaxed.owl cilium basal body|basal body|cilial basal body|microtubule basal body|kinetosome NIF_Subcellular:sao11978067 In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. bf 2011-12-15T10:40:20Z GO:0005932 cellular_component owl:Class GO:0033326 biolink:NamedThing cerebrospinal fluid secretion The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces. tmpzr1t_l9r_go_relaxed.owl CSF secretion biological_process owl:Class GO:0007589 biolink:NamedThing body fluid secretion The controlled release of a fluid by a cell or tissue in an animal. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0018720 biolink:NamedThing phenol kinase activity Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate. tmpzr1t_l9r_go_relaxed.owl MetaCyc:PHENOLPHOS-RXN|UM-BBD_reactionID:r0155 molecular_function owl:Class GO:0016773 biolink:NamedThing phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). tmpzr1t_l9r_go_relaxed.owl EC:2.7.1.-|Reactome:R-HSA-2161193 molecular_function owl:Class GO:0046907 biolink:NamedThing intracellular transport The directed movement of substances within a cell. tmpzr1t_l9r_go_relaxed.owl single organism intracellular transport|single-organism intracellular transport jl 2013-12-18T14:04:50Z GO:1902582 biological_process owl:Class GO:0051649 biolink:NamedThing establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. tmpzr1t_l9r_go_relaxed.owl establishment of cellular localization|positioning within cell|establishment of intracellular localization|establishment of localisation in cell|establishment of localization within cell biological_process owl:Class GO:0000491 biolink:NamedThing small nucleolar ribonucleoprotein complex assembly The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex. tmpzr1t_l9r_go_relaxed.owl snoRNP assembly biological_process owl:Class GO:0022618 biolink:NamedThing ribonucleoprotein complex assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. tmpzr1t_l9r_go_relaxed.owl RNA-protein complex assembly|RNP complex assembly|protein-RNA complex assembly biological_process owl:Class GO:1900884 biolink:NamedThing regulation of tridecane biosynthetic process Any process that modulates the frequency, rate or extent of tridecane biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of tridecane synthesis|regulation of tridecane anabolism|regulation of tridecane biosynthesis|regulation of tridecane formation tt 2012-06-13T03:00:31Z biological_process owl:Class GO:1900893 biolink:NamedThing regulation of tridecane metabolic process Any process that modulates the frequency, rate or extent of tridecane metabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of tridecane metabolism tt 2012-06-13T03:14:40Z biological_process owl:Class GO:1901314 biolink:NamedThing regulation of histone H2A K63-linked ubiquitination Any process that modulates the frequency, rate or extent of histone H2A K63-linked ubiquitination. tmpzr1t_l9r_go_relaxed.owl tb 2012-08-22T20:29:04Z biological_process owl:Class GO:1904481 biolink:NamedThing response to tetrahydrofolate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus. tmpzr1t_l9r_go_relaxed.owl hal 2015-07-14T14:49:17Z biological_process owl:Class GO:1901700 biolink:NamedThing response to oxygen-containing compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. tmpzr1t_l9r_go_relaxed.owl response to oxygen molecular entity pr 2012-12-13T15:11:37Z biological_process owl:Class GO:1905751 biolink:NamedThing positive regulation of endosome to plasma membrane protein transport Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport. tmpzr1t_l9r_go_relaxed.owl up-regulation of endosome to plasma membrane protein transport|upregulation of endosome to plasma membrane protein transport|up regulation of endosome to plasma membrane protein transport|activation of endosome to plasma membrane protein transport pga 2016-12-09T13:46:30Z biological_process owl:Class GO:1905012 biolink:NamedThing regulation of 'de novo' NAD biosynthetic process from tryptophan Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan. tmpzr1t_l9r_go_relaxed.owl regulation of de novo NAD biosynthetic process from tryptophan bf 2016-03-03T10:00:50Z biological_process owl:Class GO:0016649 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound. tmpzr1t_l9r_go_relaxed.owl EC:1.5.5.- molecular_function owl:Class GO:0016645 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. tmpzr1t_l9r_go_relaxed.owl oxidoreductase activity, acting on the CH-NH group of donors, other acceptors EC:1.5.-.- molecular_function owl:Class GO:0072090 biolink:NamedThing mesenchymal stem cell proliferation involved in nephron morphogenesis The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron. tmpzr1t_l9r_go_relaxed.owl mah 2010-02-08T02:05:54Z biological_process owl:Class GO:0097168 biolink:NamedThing mesenchymal stem cell proliferation The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. tmpzr1t_l9r_go_relaxed.owl MSC proliferation pr 2011-09-29T04:44:48Z biological_process owl:Class GO:0033771 biolink:NamedThing licodione synthase activity Catalysis of the reaction: H(+) + liquiritigenin + NADPH + O(2) = H(2)O + licodione + NADP(+). tmpzr1t_l9r_go_relaxed.owl (2S)-flavanone 2-hydroxylase activity|liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity KEGG_REACTION:R07198|MetaCyc:1.14.13.87-RXN|RHEA:15697|EC:1.14.14.140 molecular_function owl:Class GO:0016709 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. tmpzr1t_l9r_go_relaxed.owl oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen Reactome:R-HSA-2162187|Reactome:R-HSA-2162194|EC:1.14.13.- molecular_function owl:Class GO:0080190 biolink:NamedThing lateral growth Growth of a plant axis (shoot axis or root) that originates from a lateral meristem. tmpzr1t_l9r_go_relaxed.owl Includes thickening of plant axes (PO:0025004) due to the activity of a cambium (PO:0005597), known as secondary growth and found in most gymnosperms and dicotyledons, a primary thickening meristem (PO:0005039) as found in many monocotyledons, some ferns and some cycads, or secondary thickening meristem, (PO:0025414) as found in some monocotyledons. dhl 2012-12-06T15:42:28Z biological_process owl:Class GO:0040007 biolink:NamedThing growth The increase in size or mass of an entire organism, a part of an organism or a cell. tmpzr1t_l9r_go_relaxed.owl non-developmental growth|growth pattern See also the biological process term 'cell growth ; GO:0016049'. GO:0048590 biological_process owl:Class GO:2000678 biolink:NamedThing negative regulation of transcription regulatory region DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding. tmpzr1t_l9r_go_relaxed.owl yaf 2011-05-09T03:28:14Z biological_process owl:Class GO:0043392 biolink:NamedThing negative regulation of DNA binding Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). tmpzr1t_l9r_go_relaxed.owl down-regulation of DNA binding|inhibition of DNA binding|down regulation of DNA binding|downregulation of DNA binding biological_process owl:Class GO:0002830 biolink:NamedThing positive regulation of type 2 immune response Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. tmpzr1t_l9r_go_relaxed.owl activation of type 2 immune response|positive regulation of Th2 immune response|up regulation of type 2 immune response|stimulation of type 2 immune response|up-regulation of type 2 immune response|upregulation of type 2 immune response|positive regulation of T-helper 2 type immune response biological_process owl:Class GO:0002828 biolink:NamedThing regulation of type 2 immune response Any process that modulates the frequency, rate, or extent of a type 2 immune response. tmpzr1t_l9r_go_relaxed.owl regulation of Th2 immune response|regulation of T-helper 2 type immune response biological_process owl:Class GO:0017096 biolink:NamedThing acetylserotonin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine. tmpzr1t_l9r_go_relaxed.owl S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity|N-acetylserotonin O-methyltransferase activity|acetylserotonin methyltransferase activity|hydroxyindole O-methyltransferase activity|hydroxyindole methyltransferase activity EC:2.1.1.4|MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN|RHEA:15573 GO:0017097 molecular_function owl:Class GO:0060053 biolink:NamedThing neurofilament cytoskeleton Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0045111 biolink:NamedThing intermediate filament cytoskeleton Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0045621 biolink:NamedThing positive regulation of lymphocyte differentiation Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. tmpzr1t_l9r_go_relaxed.owl up regulation of lymphocyte differentiation|up-regulation of lymphocyte differentiation|upregulation of lymphocyte differentiation|positive regulation of lymphocyte development|stimulation of lymphocyte differentiation|activation of lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:0045619 biolink:NamedThing regulation of lymphocyte differentiation Any process that modulates the frequency, rate or extent of lymphocyte differentiation. tmpzr1t_l9r_go_relaxed.owl regulation of lymphocyte development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:1905412 biolink:NamedThing negative regulation of mitotic cohesin loading Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin loading. tmpzr1t_l9r_go_relaxed.owl vw 2016-08-27T15:24:35Z biological_process owl:Class GO:0090519 biolink:NamedThing anoxia protection Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia. tmpzr1t_l9r_go_relaxed.owl tb 2012-12-21T15:37:37Z biological_process owl:Class GO:0034059 biolink:NamedThing response to anoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. tmpzr1t_l9r_go_relaxed.owl response to anoxic stress Note that this term should not be confused with 'response to hypoxia ; GO:0001666'. biological_process owl:Class GO:0048766 biolink:NamedThing root hair initiation The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0000904 biolink:NamedThing cell morphogenesis involved in differentiation The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0031438 biolink:NamedThing negative regulation of mRNA cleavage Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage. tmpzr1t_l9r_go_relaxed.owl downregulation of mRNA cleavage|down-regulation of mRNA cleavage|down regulation of mRNA cleavage|inhibition of mRNA cleavage biological_process owl:Class GO:0010243 biolink:NamedThing response to organonitrogen compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. tmpzr1t_l9r_go_relaxed.owl response to organic nitrogen biological_process owl:Class GO:0010033 biolink:NamedThing response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. tmpzr1t_l9r_go_relaxed.owl process resulting in tolerance to organic substance GO:1990367 biological_process owl:Class GO:0030211 biolink:NamedThing heparin catabolic process The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. tmpzr1t_l9r_go_relaxed.owl heparan sulfate catabolic process|heparin breakdown|heparin catabolism|heparin degradation biological_process owl:Class GO:0030202 biolink:NamedThing heparin metabolic process The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. tmpzr1t_l9r_go_relaxed.owl heparin metabolism|heparan sulfate metabolic process biological_process owl:Class GO:1903687 biolink:NamedThing negative regulation of border follicle cell migration Any process that stops, prevents or reduces the frequency, rate or extent of border follicle cell migration. tmpzr1t_l9r_go_relaxed.owl inhibition of border follicle cell migration als 2014-12-01T13:41:05Z biological_process owl:Class GO:0034040 biolink:NamedThing ATPase-coupled lipid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out). tmpzr1t_l9r_go_relaxed.owl ATP-dependent lipid transmembrane transporter activity|lipid-transporting ATPase activity molecular_function owl:Class GO:0042626 biolink:NamedThing ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. tmpzr1t_l9r_go_relaxed.owl P-P-bond-hydrolysis-driven transmembrane transporter activity|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|ATP-coupled transmembrane transporter activity|ATP-dependent transmembrane transporter activity|ATPase activity, coupled to transmembrane movement of substances|P-P-bond-hydrolysis-driven transporter|ATPase activity, coupled to movement of substances https://github.com/geneontology/go-ontology/issues/19965|https://github.com/geneontology/go-ontology/issues/17373|https://github.com/geneontology/go-ontology/issues/14642 Reactome:R-HSA-2161538|Reactome:R-HSA-1467457|Reactome:R-HSA-9033505|Reactome:R-HSA-9033499|Reactome:R-HSA-2161506 GO:0043492|GO:0016820|GO:0015405 molecular_function owl:Class GO:0032377 biolink:NamedThing regulation of intracellular lipid transport Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0032368 biolink:NamedThing regulation of lipid transport Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0045856 biolink:NamedThing positive regulation of pole plasm oskar mRNA localization Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. tmpzr1t_l9r_go_relaxed.owl activation of pole plasm oskar mRNA localization|positive regulation of pole plasm oskar mRNA localisation|positive regulation of oocyte pole plasm oskar mRNA localization|upregulation of pole plasm oskar mRNA localization|stimulation of pole plasm oskar mRNA localization|up regulation of pole plasm oskar mRNA localization|up-regulation of pole plasm oskar mRNA localization biological_process owl:Class GO:1905695 biolink:NamedThing positive regulation of phosphatidic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of phosphatidic acid biosynthetic process. tmpzr1t_l9r_go_relaxed.owl up regulation of phosphatidic acid anabolism|up-regulation of phosphatidic acid synthesis|upregulation of phosphatidic acid formation|activation of phosphatidic acid formation|activation of phosphatidic acid anabolism|upregulation of phosphatidic acid synthesis|up regulation of phosphatidic acid biosynthetic process|up regulation of phosphatidic acid formation|up-regulation of phosphatidic acid formation|activation of phosphatidic acid biosynthesis|up-regulation of phosphatidic acid biosynthesis|up-regulation of phosphatidic acid biosynthetic process|activation of phosphatidic acid synthesis|up regulation of phosphatidic acid synthesis|activation of phosphatidic acid biosynthetic process|upregulation of phosphatidic acid biosynthetic process|up regulation of phosphatidic acid biosynthesis|positive regulation of phosphatidic acid formation|upregulation of phosphatidic acid anabolism|up-regulation of phosphatidic acid anabolism|positive regulation of phosphatidic acid synthesis|positive regulation of phosphatidic acid anabolism|positive regulation of phosphatidic acid biosynthesis|upregulation of phosphatidic acid biosynthesis bc 2016-11-14T14:48:24Z biological_process owl:Class GO:0071073 biolink:NamedThing positive regulation of phospholipid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. tmpzr1t_l9r_go_relaxed.owl positive regulation of phospholipid biosynthesis|up regulation of phospholipid biosynthetic process|positive regulation of phospholipid anabolism|stimulation of phospholipid biosynthetic process|upregulation of phospholipid biosynthetic process|activation of phospholipid biosynthetic process|positive regulation of phospholipid synthesis|positive regulation of phospholipid formation|up-regulation of phospholipid biosynthetic process mah 2009-11-04T03:18:51Z biological_process owl:Class GO:0062156 biolink:NamedThing mitochondrial ATP-gated potassium channel activity Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane. tmpzr1t_l9r_go_relaxed.owl mitoK-ATP activity|mitochondrial potassium channel activity dph 2019-09-20T16:07:07Z molecular_function owl:Class GO:0099094 biolink:NamedThing ligand-gated cation channel activity Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0035500 biolink:NamedThing MH2 domain binding Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. tmpzr1t_l9r_go_relaxed.owl MAD homology 2 domain binding bf 2010-04-29T03:14:32Z molecular_function owl:Class GO:0019904 biolink:NamedThing protein domain specific binding Binding to a specific domain of a protein. tmpzr1t_l9r_go_relaxed.owl protein domain-specific binding molecular_function owl:Class GO:0032981 biolink:NamedThing mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. tmpzr1t_l9r_go_relaxed.owl mitochondrial NADH dehydrogenase complex (ubiquinone) assembly|mitochondrial complex I assembly biological_process owl:Class GO:0033108 biolink:NamedThing mitochondrial respiratory chain complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0009059 biolink:NamedThing macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. tmpzr1t_l9r_go_relaxed.owl macromolecule anabolism|macromolecule formation|macromolecule biosynthesis|macromolecule synthesis|biopolymer biosynthetic process GO:0043284 biological_process owl:Class GO:0043170 biolink:NamedThing macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. tmpzr1t_l9r_go_relaxed.owl multicellular organismal macromolecule metabolic process|organismal macromolecule metabolism|macromolecule metabolism|biopolymer metabolic process GO:0043283|GO:0044259 biological_process owl:Class GO:0004658 biolink:NamedThing propionyl-CoA carboxylase activity Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. tmpzr1t_l9r_go_relaxed.owl PCCase activity|propionyl coenzyme A carboxylase activity|propanoyl-CoA:carbon-dioxide ligase (ADP-forming) EC:6.4.1.3|MetaCyc:PROPIONYL-COA-CARBOXY-RXN|Reactome:R-HSA-71031|RHEA:23720 molecular_function owl:Class GO:0016421 biolink:NamedThing CoA carboxylase activity Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:2000281 biolink:NamedThing regulation of histone H3-T3 phosphorylation Any process that modulates the frequency, rate or extent of histone H3-T3 phosphorylation. tmpzr1t_l9r_go_relaxed.owl vw 2010-12-10T11:48:31Z biological_process owl:Class GO:1903702 biolink:NamedThing esophagus development The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. tmpzr1t_l9r_go_relaxed.owl esophageal development|oesophagus development|gullet development cls 2014-12-03T14:41:30Z biological_process owl:Class GO:0048513 biolink:NamedThing animal organ development Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. tmpzr1t_l9r_go_relaxed.owl organogenesis|development of an organ Wikipedia:Organogenesis biological_process owl:Class GO:2000700 biolink:NamedThing positive regulation of cardiac muscle cell myoblast differentiation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. tmpzr1t_l9r_go_relaxed.owl positive regulation of cardiac myoblast differentiation|positive regulation of myocardial precursor cell differentiation yaf 2011-05-25T09:08:09Z biological_process owl:Class GO:0045663 biolink:NamedThing positive regulation of myoblast differentiation Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. tmpzr1t_l9r_go_relaxed.owl upregulation of myoblast differentiation|activation of myoblast differentiation|stimulation of myoblast differentiation|up regulation of myoblast differentiation|up-regulation of myoblast differentiation biological_process owl:Class GO:0006967 biolink:NamedThing positive regulation of antifungal peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis. tmpzr1t_l9r_go_relaxed.owl antifungal peptide induction|activation of antifungal peptide biosynthetic process|up-regulation of antifungal peptide biosynthetic process|antifungal polypeptide induction|upregulation of antifungal peptide biosynthetic process|stimulation of antifungal peptide biosynthetic process|up regulation of antifungal peptide biosynthetic process biological_process owl:Class GO:0002807 biolink:NamedThing positive regulation of antimicrobial peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis. tmpzr1t_l9r_go_relaxed.owl up-regulation of antimicrobial peptide biosynthetic process|stimulation of antimicrobial peptide biosynthetic process|upregulation of antimicrobial peptide biosynthetic process|activation of antimicrobial peptide biosynthetic process|up regulation of antimicrobial peptide biosynthetic process biological_process owl:Class GO:0000749 biolink:NamedThing response to pheromone triggering conjugation with cellular fusion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae. tmpzr1t_l9r_go_relaxed.owl response to pheromone during conjugation with cellular fusion GO:0030434|GO:0007328 biological_process owl:Class GO:0019236 biolink:NamedThing response to pheromone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. tmpzr1t_l9r_go_relaxed.owl pheromone response biological_process owl:Class GO:0017148 biolink:NamedThing negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. tmpzr1t_l9r_go_relaxed.owl negative regulation of protein synthesis|negative regulation of protein biosynthetic process|down regulation of protein biosynthetic process|negative regulation of protein anabolism|inhibition of protein biosynthetic process|protein biosynthetic process inhibitor activity|downregulation of protein biosynthetic process|negative regulation of protein formation|down-regulation of protein biosynthetic process|protein biosynthesis inhibitor activity|negative regulation of protein biosynthesis GO:0016478 biological_process owl:Class GO:0006417 biolink:NamedThing regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. tmpzr1t_l9r_go_relaxed.owl regulation of protein anabolism|regulation of protein biosynthesis|regulation of protein synthesis|regulation of protein formation GO:0006445 biological_process owl:Class GO:0051009 biolink:NamedThing O-acetylhomoserine sulfhydrylase activity Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate. tmpzr1t_l9r_go_relaxed.owl RHEA:27822|MetaCyc:ACETYLHOMOSER-CYS-RXN molecular_function owl:Class GO:0016835 biolink:NamedThing carbon-oxygen lyase activity Catalysis of the breakage of a carbon-oxygen bond. tmpzr1t_l9r_go_relaxed.owl other carbon-oxygen lyase activity EC:4.2.-.- molecular_function owl:Class GO:1990354 biolink:NamedThing activated SUMO-E1 ligase complex A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins. tmpzr1t_l9r_go_relaxed.owl SUMO-SAE1/2 complex An example of this is SAE1 in human (UniProt symbol Q9UBE0) in PMID:15660128 (inferred from direct assay). bhm 2014-03-31T13:22:45Z cellular_component owl:Class GO:0106068 biolink:NamedThing SUMO ligase complex A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex. tmpzr1t_l9r_go_relaxed.owl SUMO-protein ligase complex|Sumoylation complex|SUMO transferase complex hjd 2017-11-22T18:46:00Z cellular_component owl:Class GO:0015179 biolink:NamedThing L-amino acid transmembrane transporter activity Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. tmpzr1t_l9r_go_relaxed.owl L-amino acid transporter activity Reactome:R-HSA-212614 molecular_function owl:Class GO:0015171 biolink:NamedThing amino acid transmembrane transporter activity Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. tmpzr1t_l9r_go_relaxed.owl general amino acid permease activity|amino acid/choline transmembrane transporter activity|amino acid transporter activity|amino acid permease activity|hydroxy/aromatic amino acid permease activity Reactome:R-HSA-379415|Reactome:R-HSA-351963|Reactome:R-HSA-352379|Reactome:R-HSA-352103|Reactome:R-HSA-5660694|Reactome:R-HSA-375776|Reactome:R-HSA-352347|Reactome:R-HSA-352136|Reactome:R-HSA-352119|Reactome:R-HSA-352371|Reactome:R-HSA-5653850|Reactome:R-HSA-5660890|Reactome:R-HSA-352158|Reactome:R-HSA-375487|Reactome:R-HSA-376200|Reactome:R-HSA-352108|Reactome:R-HSA-352174|Reactome:R-HSA-888592|Reactome:R-HSA-352385|Reactome:R-HSA-352107|Reactome:R-HSA-352059|Reactome:R-HSA-5655702|Reactome:R-HSA-375417|Reactome:R-HSA-5660910|Reactome:R-HSA-5659674|Reactome:R-HSA-210439|Reactome:R-HSA-352364|Reactome:R-HSA-212642|Reactome:R-HSA-352354|Reactome:R-HSA-379432|Reactome:R-HSA-375768|Reactome:R-HSA-375770|Reactome:R-HSA-375473|Reactome:R-HSA-8952726|Reactome:R-HSA-379426|Reactome:R-HSA-5659755|Reactome:R-HSA-375405|Reactome:R-HSA-352029|Reactome:R-HSA-351987|Reactome:R-HSA-352191|Reactome:R-HSA-352052|Reactome:R-HSA-5659734|Reactome:R-HSA-375790|Reactome:R-HSA-352232|Reactome:R-HSA-352182|Reactome:R-HSA-378513 GO:0015359 molecular_function owl:Class GO:0052587 biolink:NamedThing diacetyl reductase ((R)-acetoin forming) activity Catalysis of the reaction: (R)-acetoin + NAD(+) = diacetyl + H(+) + NADH. tmpzr1t_l9r_go_relaxed.owl (R)-acetoin dehydrogenase activity MetaCyc:RXN-11036|KEGG_REACTION:R02855|EC:1.1.1.303|RHEA:22900 molecular_function owl:Class GO:0019152 biolink:NamedThing acetoin dehydrogenase activity Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. tmpzr1t_l9r_go_relaxed.owl diacetyl reductase activity EC:1.1.1.304|MetaCyc:ACETOINDEHYDROG-RXN|EC:1.1.1.303|KEGG_REACTION:R02343 molecular_function owl:Class GO:1902939 biolink:NamedThing negative regulation of intracellular calcium activated chloride channel activity Any process that stops, prevents or reduces the frequency, rate or extent of intracellular calcium activated chloride channel activity. tmpzr1t_l9r_go_relaxed.owl down regulation of intracellular calcium activated chloride channel activity|inhibition of intracellular calcium activated chloride channel activity|down-regulation of intracellular calcium activated chloride channel activity|downregulation of intracellular calcium activated chloride channel activity als 2014-04-28T08:49:14Z biological_process owl:Class GO:0008046 biolink:NamedThing axon guidance receptor activity Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. tmpzr1t_l9r_go_relaxed.owl receptor activity involved in axon guidance molecular_function owl:Class GO:0004888 biolink:NamedThing transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. tmpzr1t_l9r_go_relaxed.owl transmembrane signalling receptor activity|transmembrane receptor activity Reactome:R-HSA-193672 This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. GO:0004926|GO:0099600 molecular_function owl:Class GO:0002205 biolink:NamedThing somatic hypermutation of immunoglobulin genes involved in immune response Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response. tmpzr1t_l9r_go_relaxed.owl somatic hypermutation of antibody genes during immune response|somatic hypermutation of immunoglobulin genes during immune response biological_process owl:Class GO:0002208 biolink:NamedThing somatic diversification of immunoglobulins involved in immune response The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. tmpzr1t_l9r_go_relaxed.owl somatic diversification of immunoglobulins during immune response|somatic diversification of antibodies during immune response biological_process owl:Class GO:0003368 biolink:NamedThing cell-matrix adhesion involved in mesendodermal cell migration The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell. tmpzr1t_l9r_go_relaxed.owl dph 2009-12-08T05:26:12Z biological_process owl:Class GO:0007160 biolink:NamedThing cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0030263 biolink:NamedThing apoptotic chromosome condensation The compaction of chromatin during apoptosis. tmpzr1t_l9r_go_relaxed.owl pyknosis Wikipedia:Pyknosis biological_process owl:Class GO:0030261 biolink:NamedThing chromosome condensation The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. tmpzr1t_l9r_go_relaxed.owl eukaryotic chromosome condensation|DNA condensation|nuclear chromosome condensation GO:0000068 biological_process owl:Class GO:0042996 biolink:NamedThing regulation of Golgi to plasma membrane protein transport Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1903076 biolink:NamedThing regulation of protein localization to plasma membrane Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. tmpzr1t_l9r_go_relaxed.owl regulation of establishment of protein localization to plasma membrane|regulation of protein targeting to plasma membrane|regulation of establishment of protein localization in plasma membrane|regulation of establishment of protein localisation in plasma membrane|regulation of protein-plasma membrane targeting|regulation of protein localization in plasma membrane|regulation of protein localisation in plasma membrane tb 2009-07-10T10:32:44Z GO:1905963|GO:0090003 biological_process owl:Class GO:0060556 biolink:NamedThing regulation of vitamin D biosynthetic process Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). tmpzr1t_l9r_go_relaxed.owl dph 2009-04-13T02:42:15Z biological_process owl:Class GO:0031326 biolink:NamedThing regulation of cellular biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl regulation of cellular biosynthesis|regulation of cellular synthesis|regulation of cellular formation|regulation of cellular anabolism biological_process owl:Class GO:1904318 biolink:NamedThing regulation of smooth muscle contraction involved in micturition Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition. tmpzr1t_l9r_go_relaxed.owl regulation of urinary bladder smooth muscle contraction involved in micturition|regulation of smooth muscle contraction involved in urination sl 2015-06-10T18:46:11Z biological_process owl:Class GO:0006940 biolink:NamedThing regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0018034 biolink:NamedThing C-terminal peptidyl-alanine amidation The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein. tmpzr1t_l9r_go_relaxed.owl RESID:AA0081 biological_process owl:Class GO:0018194 biolink:NamedThing peptidyl-alanine modification The modification of peptidyl-alanine. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0021829 biolink:NamedThing oligodendrocyte cell migration from the subpallium to the cortex The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0022030 biolink:NamedThing telencephalon glial cell migration The orderly movement of glial cells through the telencephalon. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0036203 biolink:NamedThing taxoid 14-beta-hydroxylase activity Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O. tmpzr1t_l9r_go_relaxed.owl KEGG_REACTION:R09867|RHEA:31971|EC:1.14.13.146 bf 2012-04-20T02:40:54Z molecular_function owl:Class GO:0032059 biolink:NamedThing bleb A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. tmpzr1t_l9r_go_relaxed.owl plasma membrane bleb Wikipedia:Bleb_(cell_biology) cellular_component owl:Class GO:0120025 biolink:NamedThing plasma membrane bounded cell projection A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/13193 krc 2017-03-21T17:26:07Z cellular_component owl:Class GO:0018247 biolink:NamedThing protein-phosphoribosyl dephospho-coenzyme A linkage The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position. tmpzr1t_l9r_go_relaxed.owl RESID:AA0167 biological_process owl:Class GO:0018246 biolink:NamedThing protein-coenzyme A linkage The formation of a linkage between a protein amino acid and coenzyme A. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0031896 biolink:NamedThing V2 vasopressin receptor binding Binding to a V2 vasopressin receptor. tmpzr1t_l9r_go_relaxed.owl V2 vasopressin receptor ligand molecular_function owl:Class GO:0031893 biolink:NamedThing vasopressin receptor binding Binding to a vasopressin receptor. tmpzr1t_l9r_go_relaxed.owl vasopressin receptor ligand molecular_function owl:Class GO:1900918 biolink:NamedThing negative regulation of octadecene metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of octadecene metabolic process. tmpzr1t_l9r_go_relaxed.owl negative regulation of octadecene metabolism|downregulation of octadecene metabolism|down regulation of octadecene metabolism|down-regulation of octadecene metabolism|inhibition of octadecene metabolic process|down regulation of octadecene metabolic process|downregulation of octadecene metabolic process|inhibition of octadecene metabolism|down-regulation of octadecene metabolic process tt 2012-06-13T04:26:34Z biological_process owl:Class GO:1990826 biolink:NamedThing nucleoplasmic periphery of the nuclear pore complex Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex. tmpzr1t_l9r_go_relaxed.owl associated with the nuclear pore https://github.com/geneontology/go-ontology/issues/21774 sl 2015-08-19T18:26:26Z cellular_component owl:Class GO:0045290 biolink:NamedThing D-arabinose 1-dehydrogenase [NAD(P)+] activity Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+. tmpzr1t_l9r_go_relaxed.owl D-arabinose:NAD(P)+ 1-oxidoreductase activity EC:1.1.1.117|MetaCyc:1.1.1.117-RXN molecular_function owl:Class GO:0016616 biolink:NamedThing oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. tmpzr1t_l9r_go_relaxed.owl NADH-dependent glyoxylate reductase|glycolate reductase|glyoxylic acid reductase EC:1.1.1.-|Reactome:R-HSA-975629 molecular_function owl:Class GO:0019271 biolink:NamedThing aerobactin transport The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0072337 biolink:NamedThing modified amino acid transport The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl amino acid derivative transport mah 2010-11-04T12:18:23Z biological_process owl:Class GO:0061359 biolink:NamedThing regulation of Wnt signaling pathway by Wnt protein secretion Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell. tmpzr1t_l9r_go_relaxed.owl regulation of Wnt-activated signaling pathway by Wnt protein secretion|regulation of Wnt receptor signalling pathway by Wnt protein secretion|regulation of Wnt receptor signaling pathway by Wnt protein secretion dph 2010-10-08T01:18:02Z biological_process owl:Class GO:0061355 biolink:NamedThing Wnt protein secretion The controlled release of a Wnt protein from a cell. tmpzr1t_l9r_go_relaxed.owl dph 2010-10-08T01:07:48Z biological_process owl:Class GO:0002855 biolink:NamedThing regulation of natural killer cell mediated immune response to tumor cell Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0002715 biolink:NamedThing regulation of natural killer cell mediated immunity Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. tmpzr1t_l9r_go_relaxed.owl regulation of NK cell mediated immunity|regulation of natural killer cell activity GO:0045845 biological_process owl:Class GO:0008878 biolink:NamedThing glucose-1-phosphate adenylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate. tmpzr1t_l9r_go_relaxed.owl ADP-glucose pyrophosphorylase activity|glucose 1-phosphate adenylyltransferase activity|ADP-glucose synthetase activity|ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity|ADGase activity|ATP:alpha-glucose-1-phosphate adenylyl transferase activity|adenosine diphosphoglucose pyrophosphorylase activity|adenosine diphosphate glucose pyrophosphorylase activity|ADP-glucose diphosphorylase activity|ADP-glucose synthase activity|ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity|ADP glucose pyrophosphorylase activity|ADPG pyrophosphorylase activity EC:2.7.7.27|RHEA:12120|MetaCyc:GLUC1PADENYLTRANS-RXN|KEGG_REACTION:R00948 molecular_function owl:Class GO:0070566 biolink:NamedThing adenylyltransferase activity Catalysis of the transfer of an adenylyl group to an acceptor. tmpzr1t_l9r_go_relaxed.owl mah 2009-04-15T11:04:22Z molecular_function owl:Class GO:0006760 biolink:NamedThing folic acid-containing compound metabolic process The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. tmpzr1t_l9r_go_relaxed.owl folate and derivative metabolic process|vitamin M and derivative metabolic process|vitamin B9 and derivative metabolism|vitamin M and derivative metabolism|folic acid-containing compound metabolism|folate and derivative metabolism|folic acid and derivative metabolism|folic acid and derivative metabolic process|vitamin B9 and derivative metabolic process|folate-containing compound metabolic process|folate-containing compound metabolism biological_process owl:Class GO:0042558 biolink:NamedThing pteridine-containing compound metabolic process The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. tmpzr1t_l9r_go_relaxed.owl pterin metabolic process|pteridine-containing compound metabolism|pteridine and derivative metabolism|pteridine and derivative metabolic process|pterin metabolism GO:0019721 biological_process owl:Class GO:0061299 biolink:NamedThing retina vasculature morphogenesis in camera-type eye The process in which the vasculature of the retina is generated and organized. tmpzr1t_l9r_go_relaxed.owl retinal vasculature morphogenesis dph 2010-09-06T03:28:25Z biological_process owl:Class GO:0009653 biolink:NamedThing anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. tmpzr1t_l9r_go_relaxed.owl embryogenesis and morphogenesis|anatomical structure organization|morphogenesis Wikipedia:Morphogenesis biological_process owl:Class GO:2001171 biolink:NamedThing positive regulation of ATP biosynthetic process Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process. tmpzr1t_l9r_go_relaxed.owl positive regulation of ATP formation|positive regulation of ATP synthesis|positive regulation of ATP biosynthesis|positive regulation of ATP regeneration|positive regulation of ATP anabolism kmv 2011-10-26T03:18:26Z biological_process owl:Class GO:0072594 biolink:NamedThing establishment of protein localization to organelle The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. tmpzr1t_l9r_go_relaxed.owl establishment of protein localisation to organelle mah 2011-02-14T01:56:51Z biological_process owl:Class GO:0045184 biolink:NamedThing establishment of protein localization The directed movement of a protein to a specific location. tmpzr1t_l9r_go_relaxed.owl protein positioning|establishment of protein localisation|protein recruitment biological_process owl:Class GO:0120233 biolink:NamedThing prenyl-FMNH2 binding Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1. tmpzr1t_l9r_go_relaxed.owl prenylated FMNH2 binding https://github.com/geneontology/go-ontology/issues/19244 krc 2020-06-30T19:32:01Z molecular_function owl:Class GO:0043168 biolink:NamedThing anion binding Binding to an anion, a charged atom or group of atoms with a net negative charge. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0090338 biolink:NamedThing positive regulation of formin-nucleated actin cable assembly Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. tmpzr1t_l9r_go_relaxed.owl tb 2010-06-01T03:26:31Z biological_process owl:Class GO:0032233 biolink:NamedThing positive regulation of actin filament bundle assembly Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. tmpzr1t_l9r_go_relaxed.owl upregulation of actin filament bundle formation|activation of actin filament bundle formation|stimulation of actin filament bundle formation|up regulation of actin filament bundle formation|up-regulation of actin filament bundle formation biological_process owl:Class GO:0006554 biolink:NamedThing lysine catabolic process The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. tmpzr1t_l9r_go_relaxed.owl lysine degradation|lysine breakdown|lysine catabolism biological_process owl:Class GO:0009063 biolink:NamedThing cellular amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. tmpzr1t_l9r_go_relaxed.owl cellular amino acid breakdown|cellular amino acid catabolism|cellular amino acid degradation|amino acid catabolic process biological_process owl:Class GO:0070478 biolink:NamedThing nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. tmpzr1t_l9r_go_relaxed.owl 3'-5' nonsense-mediated decay|3'-5' nonsense-mediated mRNA decay|nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay|3'-5' NMD|nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay biological_process owl:Class GO:0034427 biolink:NamedThing nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. tmpzr1t_l9r_go_relaxed.owl 3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process biological_process owl:Class GO:0014059 biolink:NamedThing regulation of dopamine secretion Any process that modulates the frequency, rate or extent of the regulated release of dopamine. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0043269 biolink:NamedThing regulation of ion transport Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0097635 biolink:NamedThing extrinsic component of autophagosome membrane The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. tmpzr1t_l9r_go_relaxed.owl extrinsic component of autophagic vacuole membrane|extrinsic to autophagic vacuole membrane|autophagic vacuole peripheral membrane cellular_component owl:Class GO:0019898 biolink:NamedThing extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. tmpzr1t_l9r_go_relaxed.owl extrinsic to membrane|peripheral membrane protein Wikipedia:Peripheral_membrane_protein Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions. GO:0030396 cellular_component owl:Class GO:1904240 biolink:NamedThing negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly. tmpzr1t_l9r_go_relaxed.owl down regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|down-regulation of p97-Ufd1-Npl4 complex assembly|inhibition of p97-Ufd1-Npl4 complex assembly|down-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|negative regulation of p97-Ufd1-Npl4 complex formation|down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|down regulation of p97-Ufd1-Npl4 complex formation|negative regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|downregulation of VCP-NPL4-UFD1 AAA ATPase complex formation|downregulation of p97-Ufd1-Npl4 complex assembly|downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|downregulation of p97-Ufd1-Npl4 complex formation|inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|negative regulation of p97-Ufd1-Npl4 complex assembly|down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|downregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly|down regulation of p97-Ufd1-Npl4 complex assembly|down-regulation of p97-Ufd1-Npl4 complex formation|inhibition of VCP-NPL4-UFD1 AAA ATPase complex assembly|down regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly|inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|inhibition of p97-Ufd1-Npl4 complex formation|down-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly|inhibition of VCP-NPL4-UFD1 AAA ATPase complex formation bf 2015-05-18T09:50:27Z biological_process owl:Class GO:0031333 biolink:NamedThing negative regulation of protein-containing complex assembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. tmpzr1t_l9r_go_relaxed.owl down-regulation of protein complex assembly|downregulation of protein complex assembly|down regulation of protein complex assembly|inhibition of protein complex assembly|negative regulation of protein complex assembly biological_process owl:Class GO:0070689 biolink:NamedThing L-threonine catabolic process to propionate The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate. tmpzr1t_l9r_go_relaxed.owl L-threonine catabolism to propionate|L-threonine breakdown to propionate|threonine catabolic process to propionate|L-threonine degradation to propionate MetaCyc:PWY-5437 mah 2009-06-03T01:36:54Z biological_process owl:Class GO:0006567 biolink:NamedThing threonine catabolic process The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. tmpzr1t_l9r_go_relaxed.owl threonine catabolism|threonine breakdown|threonine degradation UM-BBD_pathwayID:met|MetaCyc:THREOCAT-PWY biological_process owl:Class GO:1901625 biolink:NamedThing cellular response to ergosterol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ergosterol stimulus. tmpzr1t_l9r_go_relaxed.owl dph 2012-11-14T13:53:51Z biological_process owl:Class GO:0036315 biolink:NamedThing cellular response to sterol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. tmpzr1t_l9r_go_relaxed.owl bf 2012-08-21T14:51:21Z biological_process owl:Class GO:1904683 biolink:NamedThing regulation of metalloendopeptidase activity Any process that modulates the frequency, rate or extent of metalloendopeptidase activity. tmpzr1t_l9r_go_relaxed.owl regulation of metalloendoproteinase activity|regulation of metalloendoprotease activity rph 2015-09-24T11:18:14Z biological_process owl:Class GO:1905048 biolink:NamedThing regulation of metallopeptidase activity Any process that modulates the frequency, rate or extent of metallopeptidase activity. tmpzr1t_l9r_go_relaxed.owl regulation of metalloproteinase activity|regulation of metalloprotease activity mm2 2016-03-15T16:44:27Z biological_process owl:Class GO:1905263 biolink:NamedThing positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. tmpzr1t_l9r_go_relaxed.owl up regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|up-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|upregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|activation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination se 2016-06-13T20:45:18Z biological_process owl:Class GO:0035426 biolink:NamedThing extracellular matrix-cell signaling Any process that mediates the transfer of information between the extracellular matrix and a cell. tmpzr1t_l9r_go_relaxed.owl cell-extracellular matrix signalling|extracellular matrix-cell signalling bf 2010-03-29T02:26:54Z biological_process owl:Class GO:0023052 biolink:NamedThing signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. tmpzr1t_l9r_go_relaxed.owl signalling|signalling process|single organism signaling|signaling process|biological signaling Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. jl 2010-02-16T09:30:50Z GO:0044700|GO:0023046 biological_process owl:Class GO:0090394 biolink:NamedThing negative regulation of excitatory postsynaptic potential Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. tmpzr1t_l9r_go_relaxed.owl negative regulation of EPSP|negative regulation of excitatory post-synaptic membrane potential|reduction of excitatory postsynaptic membrane potential tb 2010-12-15T01:43:12Z biological_process owl:Class GO:0098815 biolink:NamedThing modulation of excitatory postsynaptic potential Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1902647 biolink:NamedThing negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. tmpzr1t_l9r_go_relaxed.owl inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis di 2014-01-21T17:58:06Z biological_process owl:Class GO:0010512 biolink:NamedThing negative regulation of phosphatidylinositol biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0001919 biolink:NamedThing regulation of receptor recycling Any process that modulates the frequency, rate, or extent of receptor recycling. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0031323 biolink:NamedThing regulation of cellular metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. tmpzr1t_l9r_go_relaxed.owl regulation of cellular metabolism biological_process owl:Class GO:0003325 biolink:NamedThing pancreatic PP cell development The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. tmpzr1t_l9r_go_relaxed.owl dph 2009-11-02T08:25:03Z biological_process owl:Class GO:0002068 biolink:NamedThing glandular epithelial cell development The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0007312 biolink:NamedThing oocyte nucleus migration involved in oocyte dorsal/ventral axis specification The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster. tmpzr1t_l9r_go_relaxed.owl establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification|oocyte nucleus positioning during oocyte axis determination|oocyte axis determination, establishment of localization of nucleus|establishment of oocyte nucleus localization during oocyte axis determination|oocyte nucleus migration during oocyte axis determination|oocyte nuclear migration during oocyte axis determination|establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification|oocyte nucleus migration during oocyte axis specification|oocyte axis determination, oocyte nucleus migration|oocyte axis determination, establishment of position of nucleus|oocyte axis determination, establishment of oocyte nucleus localization|establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination|nucleus positioning in oocyte during oocyte axis determination|establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification|oocyte axis determination, oocyte nuclear migration|establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification|oocyte axis determination, positioning of nucleus|establishment of localization of oocyte nucleus during oocyte axis determination GO:0048128|GO:0030722|GO:0048126|GO:0008102 biological_process owl:Class GO:0007097 biolink:NamedThing nuclear migration The directed movement of the nucleus to a specific location within a cell. tmpzr1t_l9r_go_relaxed.owl establishment of position of nucleus|nucleus positioning|nucleus migration|nuclear positioning|positioning of nucleus|establishment of localization of nucleus|establishment of nucleus localization|nuclear movement|establishment of nucleus localisation|establishment of cell nucleus localization GO:0040023 biological_process owl:Class GO:0034134 biolink:NamedThing toll-like receptor 2 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 2. tmpzr1t_l9r_go_relaxed.owl toll-like receptor 2 signalling pathway|TLR2 signaling pathway biological_process owl:Class GO:0002224 biolink:NamedThing toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. tmpzr1t_l9r_go_relaxed.owl TLR signaling pathway|toll-like receptor signalling pathway Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses. biological_process owl:Class GO:0012511 biolink:NamedThing monolayer-surrounded lipid storage body A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins. tmpzr1t_l9r_go_relaxed.owl oleosome|oilbody|spherosome|oil body Wikipedia:Oil_body GO:0009520 cellular_component owl:Class GO:0005811 biolink:NamedThing lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. tmpzr1t_l9r_go_relaxed.owl lipid particle|lipid body|adiposome Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. cellular_component owl:Class GO:0046112 biolink:NamedThing nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. tmpzr1t_l9r_go_relaxed.owl nucleobase synthesis|nucleobase biosynthesis|nucleobase formation|nucleobase anabolism biological_process owl:Class GO:0018130 biolink:NamedThing heterocycle biosynthetic process The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). tmpzr1t_l9r_go_relaxed.owl heterocycle formation|heterocycle biosynthesis|heterocycle anabolism|heterocycle synthesis biological_process owl:Class GO:0102910 biolink:NamedThing dirigent protein activity Catalysis of the reaction: 2 H+ + 2 coniferol + O2 <=> (+)-pinoresinol + 2 H2O. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-8677 molecular_function owl:Class GO:0016682 biolink:NamedThing oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen. tmpzr1t_l9r_go_relaxed.owl laccase activity EC:1.10.3.- molecular_function owl:Class GO:0032147 biolink:NamedThing activation of protein kinase activity Any process that initiates the activity of an inactive protein kinase. tmpzr1t_l9r_go_relaxed.owl protein kinase activation biological_process owl:Class GO:0045860 biolink:NamedThing positive regulation of protein kinase activity Any process that activates or increases the frequency, rate or extent of protein kinase activity. tmpzr1t_l9r_go_relaxed.owl stimulation of protein kinase activity|up-regulation of protein kinase activity|up regulation of protein kinase activity|upregulation of protein kinase activity biological_process owl:Class GO:0050560 biolink:NamedThing aspartate-tRNA(Asn) ligase activity Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP. tmpzr1t_l9r_go_relaxed.owl aspartate-tRNAAsn ligase activity|L-aspartate:tRNAAsx ligase (AMP-forming)|nondiscriminating aspartyl-tRNA synthetase activity EC:6.1.1.23|MetaCyc:6.1.1.23-RXN|RHEA:18349 molecular_function owl:Class GO:0004812 biolink:NamedThing aminoacyl-tRNA ligase activity Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. tmpzr1t_l9r_go_relaxed.owl aminoacyl-tRNA synthetase auxiliary protein activity|ligase activity, forming aminoacyl-tRNA and related compounds|aminoacyl-tRNA synthetase activity EC:6.1.1.- Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA. GO:0017100|GO:0016876 molecular_function owl:Class GO:0062238 biolink:NamedThing Smp focus A DNA-binding ribonucleoprotein complex that contains a lncRNA complementary to the bound chromosomal locus and is involved in the tethering homologous chromosomes together during chromosome pairing at meiotic prophase I. tmpzr1t_l9r_go_relaxed.owl Smp dot dph 2020-04-20T14:23:04Z cellular_component owl:Class GO:1990904 biolink:NamedThing ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules. tmpzr1t_l9r_go_relaxed.owl intracellular ribonucleoprotein complex|extracellular ribonucleoprotein complex|RNA-protein complex|protein-RNA complex|RNP Wikipedia:Ribonucleoprotein pr 2015-11-19T12:26:37Z GO:0030529|GO:1990903 cellular_component owl:Class GO:0099640 biolink:NamedThing axo-dendritic protein transport The directed movement of proteins along microtubules in neuron projections. tmpzr1t_l9r_go_relaxed.owl axonal protein transport biological_process owl:Class GO:0008088 biolink:NamedThing axo-dendritic transport The directed movement of organelles or molecules along microtubules in neuron projections. tmpzr1t_l9r_go_relaxed.owl axonal transport|axoplasmic transport|axon cargo transport Wikipedia:Axoplasmic_transport biological_process owl:Class GO:2000399 biolink:NamedThing negative regulation of thymocyte aggregation Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation. tmpzr1t_l9r_go_relaxed.owl negative regulation of immature T cell aggregation|negative regulation of immature T-lymphocyte aggregation|negative regulation of T cell precursor aggregation|negative regulation of thymic lymphocyte aggregation|negative regulation of immature T-cell aggregation mah 2011-02-22T02:49:44Z biological_process owl:Class GO:0098882 biolink:NamedThing structural constituent of presynaptic active zone The action of a molecule that contributes to the structural integrity of a presynaptic active zone. tmpzr1t_l9r_go_relaxed.owl structural constituent of active zone molecular_function owl:Class GO:0005198 biolink:NamedThing structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0019651 biolink:NamedThing citrate catabolic process to diacetyl The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP. tmpzr1t_l9r_go_relaxed.owl diacetyl fermentation|citrate fermentation to diacetyl biological_process owl:Class GO:0019662 biolink:NamedThing non-glycolytic fermentation Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0015350 biolink:NamedThing methotrexate transmembrane transporter activity Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. tmpzr1t_l9r_go_relaxed.owl methotrexate transporter activity molecular_function owl:Class GO:0008514 biolink:NamedThing organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-2142859 molecular_function owl:Class GO:2000027 biolink:NamedThing regulation of animal organ morphogenesis Any process that modulates the frequency, rate or extent of animal organ morphogenesis. tmpzr1t_l9r_go_relaxed.owl regulation of histogenesis and organogenesis tb 2010-08-05T11:26:27Z biological_process owl:Class GO:0010359 biolink:NamedThing regulation of anion channel activity Any process that modulates the frequency, rate or extent of anion channel activity. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1903959 biolink:NamedThing regulation of anion transmembrane transport Any process that modulates the frequency, rate or extent of anion transmembrane transport. tmpzr1t_l9r_go_relaxed.owl pr 2015-02-25T13:52:25Z biological_process owl:Class GO:0060078 biolink:NamedThing regulation of postsynaptic membrane potential Any process that modulates the potential difference across a post-synaptic membrane. tmpzr1t_l9r_go_relaxed.owl regulation of post-synaptic membrane potential biological_process owl:Class GO:0042391 biolink:NamedThing regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0045729 biolink:NamedThing respiratory burst at fertilization The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes. tmpzr1t_l9r_go_relaxed.owl metabolic burst at fertilization|oxidative burst at fertilization biological_process owl:Class GO:0045730 biolink:NamedThing respiratory burst A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. tmpzr1t_l9r_go_relaxed.owl oxidative burst|metabolic burst Wikipedia:Respiratory_burst biological_process owl:Class GO:0061720 biolink:NamedThing 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). tmpzr1t_l9r_go_relaxed.owl dph 2015-07-01T08:47:30Z biological_process owl:Class GO:1902777 biolink:NamedThing 6-sulfoquinovose(1-) catabolic process The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-). tmpzr1t_l9r_go_relaxed.owl 6-sulfoquinovose(1-) breakdown|6-sulfoquinovose(1-) degradation|6-sulfoquinovose(1-) catabolism dph 2014-03-18T17:46:03Z biological_process owl:Class GO:0097340 biolink:NamedThing inhibition of cysteine-type endopeptidase activity Any process that prevents the activation of an inactive cysteine-type endopeptidase. tmpzr1t_l9r_go_relaxed.owl prevention of caspase activity|inhibition of caspase activity|prevention of cysteine-type endopeptidase activity pr 2012-06-18T11:23:05Z biological_process owl:Class GO:0097341 biolink:NamedThing zymogen inhibition Any process that prevents the proteolytic processing of an inactive enzyme to an active form. tmpzr1t_l9r_go_relaxed.owl prevention of zymogen activation pr 2012-06-18T11:25:45Z biological_process owl:Class GO:0000480 biolink:NamedThing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. tmpzr1t_l9r_go_relaxed.owl endonucleolytic cleavage at A0|endonucleolytic cleavage at A-prime biological_process owl:Class GO:0000479 biolink:NamedThing endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0090549 biolink:NamedThing response to carbon starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source. tmpzr1t_l9r_go_relaxed.owl tb 2013-04-22T13:57:16Z biological_process owl:Class GO:0042594 biolink:NamedThing response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0090696 biolink:NamedThing post-embryonic plant organ development Development, taking place during the post-embryonic phase of a plant tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. tmpzr1t_l9r_go_relaxed.owl tb 2016-08-25T16:35:55Z biological_process owl:Class GO:0009791 biolink:NamedThing post-embryonic development The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0035206 biolink:NamedThing regulation of hemocyte proliferation Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster. tmpzr1t_l9r_go_relaxed.owl regulation of arthropod blood cell proliferation biological_process owl:Class GO:0042127 biolink:NamedThing regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation. tmpzr1t_l9r_go_relaxed.owl regulation of cell proliferation biological_process owl:Class GO:0042317 biolink:NamedThing penicillin catabolic process The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. tmpzr1t_l9r_go_relaxed.owl penicillin catabolism|penicillin degradation|penicillin breakdown biological_process owl:Class GO:0030655 biolink:NamedThing beta-lactam antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. tmpzr1t_l9r_go_relaxed.owl beta-lactam antibiotic breakdown|beta-lactam antibiotic degradation|beta-lactam antibiotic catabolism biological_process owl:Class GO:0048093 biolink:NamedThing positive regulation of male pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males. tmpzr1t_l9r_go_relaxed.owl activation of male pigmentation|stimulation of male pigmentation|up-regulation of male pigmentation|up regulation of male pigmentation|upregulation of male pigmentation biological_process owl:Class GO:0048087 biolink:NamedThing positive regulation of developmental pigmentation Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. tmpzr1t_l9r_go_relaxed.owl upregulation of developmental pigmentation|activation of developmental pigmentation|up regulation of developmental pigmentation|stimulation of developmental pigmentation|up-regulation of developmental pigmentation biological_process owl:Class GO:0030886 biolink:NamedThing negative regulation of myeloid dendritic cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation. tmpzr1t_l9r_go_relaxed.owl inhibition of myeloid dendritic cell activation|downregulation of myeloid dendritic cell activation|down regulation of myeloid dendritic cell activation|down-regulation of myeloid dendritic cell activation biological_process owl:Class GO:0050077 biolink:NamedThing maleylpyruvate isomerase activity Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate. tmpzr1t_l9r_go_relaxed.owl 3-maleylpyruvate cis-trans-isomerase activity EC:5.2.1.4|MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN|RHEA:17393 molecular_function owl:Class GO:0016859 biolink:NamedThing cis-trans isomerase activity Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. tmpzr1t_l9r_go_relaxed.owl EC:5.2.-.- molecular_function owl:Class GO:0006662 biolink:NamedThing glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. tmpzr1t_l9r_go_relaxed.owl glycerol ether metabolism biological_process owl:Class GO:0018904 biolink:NamedThing ether metabolic process The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. tmpzr1t_l9r_go_relaxed.owl organic ether metabolic process|organic ether metabolism|ether metabolism biological_process owl:Class GO:0002455 biolink:NamedThing humoral immune response mediated by circulating immunoglobulin An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. tmpzr1t_l9r_go_relaxed.owl humoral defence mechanism|circulating immunoglobulin mediated immune response|circulating antibody mediated immune response|humoral immune response mediated by circulating antibody biological_process owl:Class GO:0006959 biolink:NamedThing humoral immune response An immune response mediated through a body fluid. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Humoral_immunity biological_process owl:Class GO:0140214 biolink:NamedThing positive regulation of long-chain fatty acid import into cell Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell. tmpzr1t_l9r_go_relaxed.owl pg 2018-04-10T15:15:03Z biological_process owl:Class GO:2000193 biolink:NamedThing positive regulation of fatty acid transport Any process that activates or increases the frequency, rate or extent of fatty acid transport. tmpzr1t_l9r_go_relaxed.owl rl 2010-10-18T10:37:17Z biological_process owl:Class GO:2000248 biolink:NamedThing negative regulation of establishment or maintenance of neuroblast polarity Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. tmpzr1t_l9r_go_relaxed.owl negative regulation of establishment and/or maintenance of neuroblast cell polarity vw 2010-11-11T11:40:34Z biological_process owl:Class GO:0034488 biolink:NamedThing basic amino acid transmembrane export from vacuole The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1990822 biolink:NamedThing basic amino acid transmembrane transport The directed movement of basic amino acids from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl vw 2015-08-19T07:47:00Z biological_process owl:Class GO:0008115 biolink:NamedThing sarcosine oxidase activity Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2). tmpzr1t_l9r_go_relaxed.owl sarcosine:oxygen oxidoreductase (demethylating) KEGG_REACTION:R00610|EC:1.5.3.1|RHEA:13313|MetaCyc:SARCOX-RXN molecular_function owl:Class GO:0016647 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen. tmpzr1t_l9r_go_relaxed.owl EC:1.5.3.- molecular_function owl:Class GO:0052150 biolink:NamedThing modulation by symbiont of host apoptotic process Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl modulation by organism of host apoptotic programmed cell death|modulation by symbiont of host apoptosis Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'. biological_process owl:Class GO:0042981 biolink:NamedThing regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process. tmpzr1t_l9r_go_relaxed.owl apoptosis regulator activity|regulation of apoptosis This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. biological_process owl:Class GO:1902617 biolink:NamedThing response to fluoride Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus. tmpzr1t_l9r_go_relaxed.owl kmv 2014-01-10T19:41:49Z biological_process owl:Class GO:0010035 biolink:NamedThing response to inorganic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0097251 biolink:NamedThing leukotriene B4 biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. tmpzr1t_l9r_go_relaxed.owl leukotriene B4 biosynthesis|leukotriene B4 formation|LTB4 synthesis|leukotriene B4 anabolism|leukotriene B4 synthesis|LTB4 anabolism|LTB4 formation|LTB4 biosynthesis pr 2012-02-24T09:34:01Z biological_process owl:Class GO:1901617 biolink:NamedThing organic hydroxy compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic hydroxy compound. tmpzr1t_l9r_go_relaxed.owl organic hydroxy compound formation|organic hydroxy compound synthesis|organic hydroxy compound anabolism|organic hydroxy compound biosynthesis pr 2012-11-13T12:54:36Z biological_process owl:Class GO:0051045 biolink:NamedThing negative regulation of membrane protein ectodomain proteolysis Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis. tmpzr1t_l9r_go_relaxed.owl downregulation of membrane protein ectodomain proteolysis|down-regulation of membrane protein ectodomain proteolysis|inhibition of membrane protein ectodomain proteolysis|down regulation of membrane protein ectodomain proteolysis biological_process owl:Class GO:0051043 biolink:NamedThing regulation of membrane protein ectodomain proteolysis Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0034462 biolink:NamedThing small-subunit processome assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome. tmpzr1t_l9r_go_relaxed.owl SSU processome assembly|small subunit processome assembly biological_process owl:Class GO:0140344 biolink:NamedThing triglyceride transfer activity Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location. tmpzr1t_l9r_go_relaxed.owl triglyceride carrier activity pg 2019-05-16T11:53:59Z molecular_function owl:Class GO:0120013 biolink:NamedThing lipid transfer activity Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids. tmpzr1t_l9r_go_relaxed.owl lipid carrier activity|intermembrane lipid transfer activity https://github.com/geneontology/go-ontology/issues/17648|https://github.com/geneontology/go-ontology/issues/12329 krc 2017-03-17T03:17:29Z molecular_function owl:Class GO:0050421 biolink:NamedThing nitrite reductase (NO-forming) activity Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+. tmpzr1t_l9r_go_relaxed.owl cd-cytochrome nitrite reductase activity|NO-forming nitrite reductase activity|cytochrome cd1 activity|nitrite reductase (cytochrome; NO-forming) activity|NO-forming nitrite reductase (cytochrome) activity|nitric-oxide:ferricytochrome-c oxidoreductase activity|Pseudomonas cytochrome oxidase activity|[nitrite reductase (cytochrome)]|cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity|methyl viologen-nitrite reductase activity|cytochrome cd activity|cytochrome c-551:O2, NO2+ oxidoreductase activity MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN|EC:1.7.2.1|RHEA:15233 Note that EC:1.7.99.3 was merged into this term. GO:0016666 molecular_function owl:Class GO:0098809 biolink:NamedThing nitrite reductase activity Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0035162 biolink:NamedThing embryonic hemopoiesis The stages of blood cell formation that take place within the embryo. tmpzr1t_l9r_go_relaxed.owl embryonic haemopoiesis|embryonic hematopoiesis|embryonic haematopoiesis biological_process owl:Class GO:0030097 biolink:NamedThing hemopoiesis The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. tmpzr1t_l9r_go_relaxed.owl hematopoiesis|blood cell biosynthesis|haemopoiesis|blood cell formation Wikipedia:Haematopoiesis biological_process owl:Class GO:1902227 biolink:NamedThing negative regulation of macrophage colony-stimulating factor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. tmpzr1t_l9r_go_relaxed.owl down-regulation of M-CSF signaling pathway|down regulation of macrophage colony-stimulating factor signaling pathway|inhibition of macrophage colony-stimulating factor signalling pathway|negative regulation of M-CSF signaling pathway|downregulation of macrophage colony-stimulating factor signaling pathway|downregulation of macrophage colony-stimulating factor signalling pathway|inhibition of macrophage colony-stimulating factor signaling pathway|inhibition of M-CSF signaling pathway|downregulation of M-CSF signaling pathway|down regulation of macrophage colony-stimulating factor signalling pathway|negative regulation of macrophage colony-stimulating factor signalling pathway|down-regulation of macrophage colony-stimulating factor signaling pathway|down-regulation of macrophage colony-stimulating factor signalling pathway|down regulation of M-CSF signaling pathway lb 2013-06-14T06:28:54Z biological_process owl:Class GO:1902226 biolink:NamedThing regulation of macrophage colony-stimulating factor signaling pathway Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. tmpzr1t_l9r_go_relaxed.owl regulation of M-CSF signaling pathway|regulation of macrophage colony-stimulating factor signalling pathway lb 2013-06-14T06:28:42Z biological_process owl:Class GO:0001960 biolink:NamedThing negative regulation of cytokine-mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway. tmpzr1t_l9r_go_relaxed.owl negative regulation of cytokine mediated signaling pathway|negative regulation of cytokine mediated signalling pathway|negative regulation of cytokine and chemokine mediated signaling pathway|downregulation of cytokine mediated signaling pathway|inhibition of cytokine mediated signaling pathway|down regulation of cytokine mediated signaling pathway|down-regulation of cytokine mediated signaling pathway biological_process owl:Class GO:0015021 biolink:NamedThing heparin-sulfate lyase activity Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar. tmpzr1t_l9r_go_relaxed.owl heparitinase I|heparin-sulphate lyase activity|heparitinase II|[heparan sulfate]-sulfate lyase activity|heparitin-sulfate lyase activity|heparin-sulfate eliminase activity MetaCyc:4.2.2.8-RXN|EC:4.2.2.8 molecular_function owl:Class GO:0016837 biolink:NamedThing carbon-oxygen lyase activity, acting on polysaccharides Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide. tmpzr1t_l9r_go_relaxed.owl EC:4.2.2.- molecular_function owl:Class GO:0018118 biolink:NamedThing peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide. tmpzr1t_l9r_go_relaxed.owl peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine RESID:AA0229 biological_process owl:Class GO:0018198 biolink:NamedThing peptidyl-cysteine modification The modification of peptidyl-cysteine. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0031745 biolink:NamedThing cysteinyl leukotriene receptor binding Binding to a cysteinyl leukotriene receptor. tmpzr1t_l9r_go_relaxed.owl cysteinyl leukotriene receptor ligand molecular_function owl:Class GO:0001664 biolink:NamedThing G protein-coupled receptor binding Binding to a G protein-coupled receptor. tmpzr1t_l9r_go_relaxed.owl G protein coupled receptor binding|G-protein-coupled receptor ligand|G-protein coupled receptor binding|G protein coupled receptor ligand Reactome:R-HSA-500717 molecular_function owl:Class GO:0035736 biolink:NamedThing cell proliferation involved in compound eye morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. tmpzr1t_l9r_go_relaxed.owl bf 2011-03-17T10:57:03Z biological_process owl:Class GO:0008283 biolink:NamedThing cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. tmpzr1t_l9r_go_relaxed.owl cell proliferation This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. biological_process owl:Class GO:0072523 biolink:NamedThing purine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. tmpzr1t_l9r_go_relaxed.owl purine-containing compound degradation|purine and derivative catabolic process|purine-containing compound breakdown|purine-containing compound catabolism mah 2011-01-04T03:17:20Z biological_process owl:Class GO:0045724 biolink:NamedThing positive regulation of cilium assembly Any process that activates or increases the frequency, rate or extent of the formation of a cilium. tmpzr1t_l9r_go_relaxed.owl up-regulation of cilium assembly|up regulation of cilium assembly|activation of cilium assembly|upregulation of cilium assembly|positive regulation of flagellum biogenesis|stimulation of cilium assembly|positive regulation of flagellum assembly biological_process owl:Class GO:0120034 biolink:NamedThing positive regulation of plasma membrane bounded cell projection assembly Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/13298 krc 2017-04-26T04:34:45Z biological_process owl:Class GO:0032285 biolink:NamedThing non-myelinated axon ensheathment The process in which a non-myelinating glial cell membrane closes around an axon. tmpzr1t_l9r_go_relaxed.owl ensheathment of non-myelinated axons biological_process owl:Class GO:0008366 biolink:NamedThing axon ensheathment Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. tmpzr1t_l9r_go_relaxed.owl cellular nerve ensheathment|nerve ensheathment|cellular axon ensheathment GO:0042553 biological_process owl:Class GO:0045740 biolink:NamedThing positive regulation of DNA replication Any process that activates or increases the frequency, rate or extent of DNA replication. tmpzr1t_l9r_go_relaxed.owl stimulation of DNA replication|activation of DNA replication|up-regulation of DNA replication|up regulation of DNA replication|upregulation of DNA replication biological_process owl:Class GO:0006275 biolink:NamedThing regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0070101 biolink:NamedThing positive regulation of chemokine-mediated signaling pathway Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor. tmpzr1t_l9r_go_relaxed.owl positive regulation of chemokine-mediated signalling pathway biological_process owl:Class GO:0001961 biolink:NamedThing positive regulation of cytokine-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway. tmpzr1t_l9r_go_relaxed.owl positive regulation of cytokine and chemokine mediated signaling pathway|positive regulation of cytokine mediated signaling pathway|positive regulation of cytokine mediated signalling pathway|upregulation of cytokine mediated signaling pathway|up regulation of cytokine mediated signaling pathway|activation of cytokine mediated signaling pathway|stimulation of cytokine mediated signaling pathway|up-regulation of cytokine mediated signaling pathway biological_process owl:Class GO:0004939 biolink:NamedThing beta-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. tmpzr1t_l9r_go_relaxed.owl beta adrenoceptor molecular_function owl:Class GO:0004935 biolink:NamedThing adrenergic receptor activity Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. tmpzr1t_l9r_go_relaxed.owl adrenoceptor activity Wikipedia:Adrenergic_receptor molecular_function owl:Class GO:0042615 biolink:NamedThing CD154 receptor binding Binding to CD154, a receptor found on the surface of some activated lymphocytes. tmpzr1t_l9r_go_relaxed.owl CD40 receptor activity|CD40L binding molecular_function owl:Class GO:0005102 biolink:NamedThing signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. tmpzr1t_l9r_go_relaxed.owl receptor binding|receptor ligand|receptor-associated protein activity Wikipedia:Ligand_(biochemistry) Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. molecular_function owl:Class GO:0050936 biolink:NamedThing xanthophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance. tmpzr1t_l9r_go_relaxed.owl xanthophore cell differentiation Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. biological_process owl:Class GO:0050931 biolink:NamedThing pigment cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. tmpzr1t_l9r_go_relaxed.owl pigmented cell differentiation|chromatophore differentiation Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. GO:0043357|GO:0043358 biological_process owl:Class GO:1902520 biolink:NamedThing response to doxorubicin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus. tmpzr1t_l9r_go_relaxed.owl Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. dw 2013-12-02T09:44:13Z biological_process owl:Class GO:1903416 biolink:NamedThing response to glycoside Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to ouabain rl 2014-09-05T12:41:01Z biological_process owl:Class GO:1990153 biolink:NamedThing maintenance of protein localization to heterochromatin A process in which a protein is maintained in a location in telomeric heterochromatin. tmpzr1t_l9r_go_relaxed.owl maintenance of protein location in heterochromatin|maintenance of protein localisation to heterochromatin mah 2013-07-31T15:11:37Z biological_process owl:Class GO:0032507 biolink:NamedThing maintenance of protein location in cell Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. tmpzr1t_l9r_go_relaxed.owl maintenance of protein localization in cell biological_process owl:Class GO:0035682 biolink:NamedThing toll-like receptor 21 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 21. tmpzr1t_l9r_go_relaxed.owl TLR21 signaling pathway|toll-like receptor 21 signalling pathway bf 2011-02-21T02:39:39Z biological_process owl:Class GO:0020027 biolink:NamedThing hemoglobin metabolic process The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. tmpzr1t_l9r_go_relaxed.owl haemoglobin metabolic process|haemoglobin metabolism|hemoglobin metabolism biological_process owl:Class GO:0044260 biolink:NamedThing cellular macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl cellular biopolymer metabolic process|cellular macromolecule metabolism GO:0034960 biological_process owl:Class GO:0002494 biolink:NamedThing lipid antigen transport The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0006869 biolink:NamedThing lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0008291 biolink:NamedThing acetylcholine metabolic process The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. tmpzr1t_l9r_go_relaxed.owl acetylcholine metabolism biological_process owl:Class GO:0042133 biolink:NamedThing neurotransmitter metabolic process The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. tmpzr1t_l9r_go_relaxed.owl neurotransmitter metabolism biological_process owl:Class GO:0140255 biolink:NamedThing regulation of cellular response to phosphate starvation Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation. tmpzr1t_l9r_go_relaxed.owl pg 2018-09-07T17:11:42Z biological_process owl:Class GO:0080135 biolink:NamedThing regulation of cellular response to stress Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). tmpzr1t_l9r_go_relaxed.owl dhl 2009-05-06T05:02:52Z biological_process owl:Class GO:0032077 biolink:NamedThing positive regulation of deoxyribonuclease activity Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. tmpzr1t_l9r_go_relaxed.owl DNase activator|activation of deoxyribonuclease activity|up regulation of deoxyribonuclease activity|up-regulation of deoxyribonuclease activity|deoxyribonuclease activator|stimulation of deoxyribonuclease activity|upregulation of deoxyribonuclease activity biological_process owl:Class GO:0004062 biolink:NamedThing aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. tmpzr1t_l9r_go_relaxed.owl phenol sulfotransferase activity|phenol sulfokinase activity|dopamine sulfotransferase activity|p-nitrophenol sulfotransferase activity|1-naphthol phenol sulfotransferase activity|aryl sulphotransferase activity|2-naphtholsulfotransferase activity|ritodrine sulfotransferase activity|3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity|4-nitrocatechol sulfokinase activity|sulfokinase activity|PST|arylsulfotransferase MetaCyc:ARYL-SULFOTRANSFERASE-RXN|EC:2.8.2.1|Reactome:R-HSA-158849|Reactome:R-HSA-159358|Reactome:R-HSA-176474|Reactome:R-HSA-158468|Reactome:R-HSA-158860|RHEA:12164|Reactome:R-HSA-176646|Reactome:R-HSA-176585 molecular_function owl:Class GO:0008146 biolink:NamedThing sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. tmpzr1t_l9r_go_relaxed.owl sulphotransferase activity Reactome:R-HSA-2022061|Reactome:R-HSA-176669|Reactome:R-HSA-176588|EC:2.8.2.-|Reactome:R-HSA-176604 molecular_function owl:Class GO:0042009 biolink:NamedThing interleukin-15 binding Binding to interleukin-15. tmpzr1t_l9r_go_relaxed.owl IL-15 binding molecular_function owl:Class GO:0019955 biolink:NamedThing cytokine binding Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. tmpzr1t_l9r_go_relaxed.owl IL binding|interleukin binding GO:0019965 molecular_function owl:Class GO:0048667 biolink:NamedThing cell morphogenesis involved in neuron differentiation The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. tmpzr1t_l9r_go_relaxed.owl neuron morphogenesis involved in differentiation biological_process owl:Class GO:0000902 biolink:NamedThing cell morphogenesis The developmental process in which the size or shape of a cell is generated and organized. tmpzr1t_l9r_go_relaxed.owl cellular morphogenesis GO:0045791|GO:0007148|GO:0045790 biological_process owl:Class GO:1900105 biolink:NamedThing negative regulation of hyaluranon cable assembly Any process that stops, prevents or reduces the frequency, rate or extent of hyaluranon cable assembly. tmpzr1t_l9r_go_relaxed.owl down-regulation of HA cable assembly|downregulation of HA cable assembly|down regulation of hyaluranon cable assembly|inhibition of HA cable assembly|negative regulation of HA cable assembly|inhibition of hyaluranon cable assembly|down regulation of HA cable assembly|downregulation of hyaluranon cable assembly|down-regulation of hyaluranon cable assembly yaf 2012-02-16T01:00:50Z biological_process owl:Class GO:1904251 biolink:NamedThing regulation of bile acid metabolic process Any process that modulates the frequency, rate or extent of bile acid metabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of bile acid metabolism bf 2015-05-20T11:04:28Z biological_process owl:Class GO:0071546 biolink:NamedThing pi-body A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes. tmpzr1t_l9r_go_relaxed.owl intermitochondrial cement mah 2010-01-12T05:44:12Z cellular_component owl:Class GO:0043186 biolink:NamedThing P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. tmpzr1t_l9r_go_relaxed.owl germline granule|nuage|polar granule GO:0018994 cellular_component owl:Class GO:0002013 biolink:NamedThing detection of carbon dioxide by vasomotor center The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0003031 biolink:NamedThing detection of carbon dioxide The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1901699 biolink:NamedThing cellular response to nitrogen compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to nitrogen molecular entity pr 2012-12-13T15:06:13Z biological_process owl:Class GO:0072052 biolink:NamedThing juxtaglomerulus cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state. tmpzr1t_l9r_go_relaxed.owl mah 2010-01-25T03:58:01Z biological_process owl:Class GO:1905284 biolink:NamedThing positive regulation of epidermal growth factor receptor signaling pathway involved in heart process Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process. tmpzr1t_l9r_go_relaxed.owl activation of EGF receptor signaling pathway involved in cardiac process|activation of EGF receptor signalling pathway involved in cardiac process|up regulation of EGF receptor signalling pathway involved in cardiac process|activation of ERBB1 signaling pathway involved in heart process|upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|up regulation of ERBB1 signaling pathway involved in heart process|upregulation of ERBB1 signaling pathway involved in cardiac process|positive regulation of EGFR signaling pathway involved in heart process|activation of EGF receptor signaling pathway involved in heart process|positive regulation of EGF receptor signalling pathway involved in cardiac process|upregulation of ERBB1 signaling pathway involved in heart process|upregulation of EGFR signaling pathway involved in cardiac process|up-regulation of EGFR signaling pathway involved in heart process|up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|positive regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|positive regulation of EGF receptor signaling pathway involved in heart process|positive regulation of ERBB1 signaling pathway involved in heart process|activation of epidermal growth factor receptor signaling pathway involved in cardiac process|up regulation of EGF receptor signaling pathway involved in cardiac process|up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|up-regulation of EGF receptor signalling pathway involved in cardiac process|positive regulation of ERBB1 signaling pathway involved in cardiac process|positive regulation of EGF receptor signaling pathway involved in cardiac process|up regulation of epidermal growth factor receptor signalling pathway involved in heart process|up regulation of EGFR signaling pathway involved in cardiac process|positive regulation of epidermal growth factor receptor signalling pathway involved in heart process|up regulation of EGFR signaling pathway involved in heart process|up-regulation of EGF receptor signalling pathway involved in heart process|up-regulation of epidermal growth factor receptor signaling pathway involved in heart process|up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|activation of ERBB1 signaling pathway involved in cardiac process|up regulation of EGF receptor signalling pathway involved in heart process|activation of EGF receptor signalling pathway involved in heart process|positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|activation of epidermal growth factor receptor signaling pathway involved in heart process|upregulation of EGFR signaling pathway involved in heart process|up-regulation of EGFR signaling pathway involved in cardiac process|upregulation of EGF receptor signalling pathway involved in cardiac process|upregulation of EGF receptor signaling pathway involved in heart process|up-regulation of epidermal growth factor receptor signalling pathway involved in heart process|upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|activation of EGFR signaling pathway involved in heart process|upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process|up-regulation of ERBB1 signaling pathway involved in cardiac process|upregulation of EGF receptor signaling pathway involved in cardiac process|up-regulation of ERBB1 signaling pathway involved in heart process|activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|up-regulation of EGF receptor signaling pathway involved in heart process|positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|up regulation of EGF receptor signaling pathway involved in heart process|positive regulation of EGF receptor signalling pathway involved in heart process|activation of EGFR signaling pathway involved in cardiac process|positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|upregulation of epidermal growth factor receptor signalling pathway involved in heart process|activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|up-regulation of EGF receptor signaling pathway involved in cardiac process|upregulation of epidermal growth factor receptor signaling pathway involved in heart process|up regulation of epidermal growth factor receptor signaling pathway involved in heart process|upregulation of epidermal growth factor receptor signalling pathway involved in cardiac process|upregulation of EGF receptor signalling pathway involved in heart process|activation of epidermal growth factor receptor signalling pathway involved in cardiac process|up regulation of ERBB1 signaling pathway involved in cardiac process|up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|positive regulation of EGFR signaling pathway involved in cardiac process|up regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|up-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|activation of epidermal growth factor receptor signalling pathway involved in heart process bc 2016-06-20T14:40:57Z biological_process owl:Class GO:1905282 biolink:NamedThing regulation of epidermal growth factor receptor signaling pathway involved in heart process Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process. tmpzr1t_l9r_go_relaxed.owl regulation of EGF receptor signalling pathway involved in cardiac process|regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|regulation of EGF receptor signalling pathway involved in heart process|regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|regulation of EGFR signaling pathway involved in heart process|regulation of EGF receptor signaling pathway involved in heart process|regulation of ERBB1 signaling pathway involved in heart process|regulation of ERBB1 signaling pathway involved in cardiac process|regulation of epidermal growth factor receptor signalling pathway involved in heart process|regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|regulation of EGF receptor signaling pathway involved in cardiac process|regulation of EGFR signaling pathway involved in cardiac process|regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process bc 2016-06-20T14:40:41Z biological_process owl:Class GO:0106121 biolink:NamedThing positive regulation of cobalamin metabolic process Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process. tmpzr1t_l9r_go_relaxed.owl hjd 2018-05-01T18:07:12Z biological_process owl:Class GO:0046136 biolink:NamedThing positive regulation of vitamin metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. tmpzr1t_l9r_go_relaxed.owl up regulation of vitamin metabolic process|activation of vitamin metabolic process|upregulation of vitamin metabolic process|stimulation of vitamin metabolic process|up-regulation of vitamin metabolic process|positive regulation of vitamin metabolism biological_process owl:Class GO:0031589 biolink:NamedThing cell-substrate adhesion The attachment of a cell to the underlying substrate via adhesion molecules. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0032745 biolink:NamedThing positive regulation of interleukin-21 production Any process that activates or increases the frequency, rate, or extent of interleukin-21 production. tmpzr1t_l9r_go_relaxed.owl stimulation of interleukin-21 production|up-regulation of interleukin-21 production|up regulation of interleukin-21 production|positive regulation of IL-21 production|activation of interleukin-21 production|upregulation of interleukin-21 production|positive regulation of interleukin-21 biosynthetic process GO:0045392 biological_process owl:Class GO:0045948 biolink:NamedThing positive regulation of translational initiation Any process that activates or increases the frequency, rate or extent of translational initiation. tmpzr1t_l9r_go_relaxed.owl stimulation of translational initiation|up-regulation of translational initiation|upregulation of translational initiation|up regulation of translational initiation|activation of translational initiation biological_process owl:Class GO:0045727 biolink:NamedThing positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. tmpzr1t_l9r_go_relaxed.owl positive regulation of protein synthesis|activation of protein biosynthetic process|positive regulation of protein biosynthetic process|up-regulation of protein biosynthetic process|positive regulation of protein biosynthesis|positive regulation of protein anabolism|up regulation of protein biosynthetic process|positive regulation of protein formation|upregulation of protein biosynthetic process|stimulation of protein biosynthetic process GO:0045946 biological_process owl:Class GO:0061942 biolink:NamedThing negative regulation of c-di-GMP signaling Any process that decreases the rate, frequency or extent of c-di-GMP signaling. tmpzr1t_l9r_go_relaxed.owl dph 2017-09-14T19:13:44Z biological_process owl:Class GO:0010648 biolink:NamedThing negative regulation of cell communication Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0021753 biolink:NamedThing superior salivary nucleus development The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0021751 biolink:NamedThing salivary nucleus development The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0110115 biolink:NamedThing Cdr2 medial cortical node complex A megadalton-sized complex at the medial cortex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent localization and phosphorylation of Wee1 during interphase. tmpzr1t_l9r_go_relaxed.owl interphase cortical node|interphase node kmv 2018-07-10T14:02:26Z cellular_component owl:Class GO:1902911 biolink:NamedThing protein kinase complex A protein complex which is capable of protein kinase activity. tmpzr1t_l9r_go_relaxed.owl An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). bhm 2014-04-17T13:52:40Z cellular_component owl:Class GO:0008120 biolink:NamedThing ceramide glucosyltransferase activity Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. tmpzr1t_l9r_go_relaxed.owl ceramide:UDP-glucose glucosyltransferase activity|UDP-glucose:ceramide glucosyltransferase activity|UDP-glucose:N-acylsphingosine D-glucosyltransferase activity|ceramide:UDPGlc glucosyltransferase activity|glucosylceramide synthase activity|UDP-glucose-ceramide glucosyltransferase activity|UDPglucose:N-acylsphingosine D-glucosyltransferase activity|uridine diphosphoglucose-ceramide glucosyltransferase activity EC:2.4.1.80|MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN|RHEA:12088|Reactome:R-HSA-1638104 molecular_function owl:Class GO:0035251 biolink:NamedThing UDP-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-1912353|MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN molecular_function owl:Class GO:1902955 biolink:NamedThing positive regulation of early endosome to recycling endosome transport Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport. tmpzr1t_l9r_go_relaxed.owl up regulation of early endosome to recycling endosome transport|upregulation of early endosome to recycling endosome transport|activation of early endosome to recycling endosome transport|up-regulation of early endosome to recycling endosome transport sjp 2014-05-02T09:06:29Z biological_process owl:Class GO:0033288 biolink:NamedThing ATPase-coupled hydroxyectoine transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out). tmpzr1t_l9r_go_relaxed.owl ATP-dependent hydroxyectoine transmembrane transporter activity|hydroxyectoine transmembrane transporter activity|hydroxyectoine-transporting ATPase activity GO:0033287 molecular_function owl:Class GO:0015651 biolink:NamedThing quaternary ammonium group transmembrane transporter activity Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. tmpzr1t_l9r_go_relaxed.owl quaternary amine transmembrane transporter activity|quaternary ammonium compound transporter activity GO:0015202 molecular_function owl:Class GO:0099140 biolink:NamedThing presynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. tmpzr1t_l9r_go_relaxed.owl dos 2017-06-09T18:34:19Z biological_process owl:Class GO:0030036 biolink:NamedThing actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. tmpzr1t_l9r_go_relaxed.owl actin cytoskeleton organization and biogenesis|actin modulating activity|actin cytoskeleton organisation biological_process owl:Class GO:0033398 biolink:NamedThing zeatin biosynthetic process The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. tmpzr1t_l9r_go_relaxed.owl zeatin biosynthesis|zeatin anabolism|zeatin formation|zeatin synthesis biological_process owl:Class GO:0072522 biolink:NamedThing purine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. tmpzr1t_l9r_go_relaxed.owl purine-containing compound formation|purine-containing compound synthesis|purine-containing compound anabolism|purine and derivative biosynthetic process|purine-containing compound biosynthesis mah 2011-01-04T03:15:29Z biological_process owl:Class GO:0102516 biolink:NamedThing delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-14448 molecular_function owl:Class GO:0016758 biolink:NamedThing hexosyltransferase activity Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). tmpzr1t_l9r_go_relaxed.owl transferase activity, transferring hexosyl groups EC:2.4.1.- molecular_function owl:Class GO:0034734 biolink:NamedThing transcription factor TFIIIC1 complex A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0090576 biolink:NamedThing RNA polymerase III transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III. tmpzr1t_l9r_go_relaxed.owl RNA polymerase III transcription factor complex tb 2014-05-09T14:04:37Z cellular_component owl:Class GO:0000960 biolink:NamedThing regulation of mitochondrial RNA catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1901627 biolink:NamedThing negative regulation of postsynaptic membrane organization Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization. tmpzr1t_l9r_go_relaxed.owl inhibition of postsynaptic membrane organisation|down regulation of postsynaptic membrane organisation|negative regulation of postsynaptic membrane organisation|down-regulation of postsynaptic membrane organization|downregulation of postsynaptic membrane organisation|negative regulation of post-synaptic membrane organization|inhibition of postsynaptic membrane organization|down-regulation of postsynaptic membrane organisation|down regulation of postsynaptic membrane organization|downregulation of postsynaptic membrane organization ans 2012-11-15T11:40:20Z biological_process owl:Class GO:1900142 biolink:NamedThing negative regulation of oligodendrocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process. tmpzr1t_l9r_go_relaxed.owl downregulation of oligodendrocyte apoptosis|downregulation of oligodendrocyte apoptotic process|negative regulation of oligodendrocyte apoptosis|down regulation of oligodendrocyte apoptosis|down-regulation of oligodendrocyte apoptosis|down regulation of oligodendrocyte apoptotic process|inhibition of oligodendrocyte apoptosis|down-regulation of oligodendrocyte apoptotic process|inhibition of oligodendrocyte apoptotic process yaf 2012-03-06T10:22:50Z biological_process owl:Class GO:0034351 biolink:NamedThing negative regulation of glial cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. tmpzr1t_l9r_go_relaxed.owl downregulation of glial cell apoptosis|inhibition of glial cell apoptosis|negative regulation of glial cell apoptosis|down-regulation of glial cell apoptosis|down regulation of glial cell apoptosis biological_process owl:Class GO:0061010 biolink:NamedThing gall bladder development The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile. tmpzr1t_l9r_go_relaxed.owl dph 2010-01-22T09:38:44Z biological_process owl:Class GO:0072112 biolink:NamedThing glomerular visceral epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. tmpzr1t_l9r_go_relaxed.owl podocyte differentiation mah 2010-02-22T10:52:11Z biological_process owl:Class GO:0072311 biolink:NamedThing glomerular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. tmpzr1t_l9r_go_relaxed.owl mah 2010-04-09T06:49:21Z biological_process owl:Class GO:0046477 biolink:NamedThing glycosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. tmpzr1t_l9r_go_relaxed.owl glycosylceramide degradation|glycosylceramide breakdown|glycosylceramide catabolism biological_process owl:Class GO:0006677 biolink:NamedThing glycosylceramide metabolic process The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. tmpzr1t_l9r_go_relaxed.owl glycosylceramide metabolism biological_process owl:Class GO:1904344 biolink:NamedThing regulation of gastric mucosal blood circulation Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. tmpzr1t_l9r_go_relaxed.owl regulation of stomach mucosal blood circulation sl 2015-06-11T21:20:31Z biological_process owl:Class GO:0033283 biolink:NamedThing ATPase-coupled organic acid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out). tmpzr1t_l9r_go_relaxed.owl organic acid-transporting ATPase activity|ATP-dependent organic acid transmembrane transporter activity molecular_function owl:Class GO:2000168 biolink:NamedThing negative regulation of planar cell polarity pathway involved in neural tube closure Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure. tmpzr1t_l9r_go_relaxed.owl dph 2010-10-05T01:08:56Z biological_process owl:Class GO:1904179 biolink:NamedThing positive regulation of adipose tissue development Any process that activates or increases the frequency, rate or extent of adipose tissue development. tmpzr1t_l9r_go_relaxed.owl positive regulation of adipogenesis|activation of adipogenesis|up regulation of adipogenesis|upregulation of adipose tissue development|up-regulation of adipogenesis|up-regulation of adipose tissue development|upregulation of adipogenesis|up regulation of adipose tissue development|activation of adipose tissue development sl 2015-04-29T20:01:13Z biological_process owl:Class GO:1904177 biolink:NamedThing regulation of adipose tissue development Any process that modulates the frequency, rate or extent of adipose tissue development. tmpzr1t_l9r_go_relaxed.owl regulation of adipogenesis sl 2015-04-29T20:01:01Z biological_process owl:Class GO:0018071 biolink:NamedThing NAD(P)-cysteine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0080134 biolink:NamedThing regulation of response to stress Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). tmpzr1t_l9r_go_relaxed.owl Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. dhl 2009-05-06T04:51:28Z biological_process owl:Class GO:0007500 biolink:NamedThing mesodermal cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. tmpzr1t_l9r_go_relaxed.owl mesoderm cell fate determination Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'. biological_process owl:Class GO:0001709 biolink:NamedThing cell fate determination A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Cell_fate_determination biological_process owl:Class GO:0042538 biolink:NamedThing hyperosmotic salinity response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. tmpzr1t_l9r_go_relaxed.owl response to hyperosmotic salt stress|salt tolerance biological_process owl:Class GO:0009651 biolink:NamedThing response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. tmpzr1t_l9r_go_relaxed.owl response to ionic osmotic stress|salinity response biological_process owl:Class GO:0002371 biolink:NamedThing dendritic cell cytokine production Any process that contributes to cytokine production by a dendritic cell. tmpzr1t_l9r_go_relaxed.owl Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class GO:0002367 biolink:NamedThing cytokine production involved in immune response The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. tmpzr1t_l9r_go_relaxed.owl cytokine production during immune response|cytokine biosynthetic process involved in immune response|cytokine secretion during immune response|cytokine secretion involved in immune response Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0002374|GO:0002375 biological_process owl:Class GO:1901547 biolink:NamedThing negative regulation of synaptic vesicle lumen acidification Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle lumen acidification. tmpzr1t_l9r_go_relaxed.owl downregulation of synaptic vesicle lumen acidification|inhibition of synaptic vesicle lumen acidification|inhibition of synaptic vesicle lumen pH reduction|negative regulation of proton loading|negative regulation of synaptic vesicle lumen pH reduction|down regulation of synaptic vesicle lumen acidification|downregulation of synaptic vesicle lumen pH reduction|down-regulation of synaptic vesicle lumen pH reduction|down regulation of synaptic vesicle lumen pH reduction|down-regulation of synaptic vesicle lumen acidification dsf 2012-10-26T16:09:28Z biological_process owl:Class GO:1904063 biolink:NamedThing negative regulation of cation transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. tmpzr1t_l9r_go_relaxed.owl downregulation of cation transmembrane transport|inhibition of cation transmembrane transport|down-regulation of cation transmembrane transport|down regulation of cation transmembrane transport sl 2015-03-18T21:11:50Z biological_process owl:Class GO:0009443 biolink:NamedThing pyridoxal 5'-phosphate salvage Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. tmpzr1t_l9r_go_relaxed.owl pyridoxal 5' phosphate salvage MetaCyc:PLPSAL-PWY biological_process owl:Class GO:0043094 biolink:NamedThing cellular metabolic compound salvage Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0062044 biolink:NamedThing negative regulation of cardiac epithelial to mesenchymal transition Any process that stops or decreases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. tmpzr1t_l9r_go_relaxed.owl dph 2018-05-10T18:21:00Z biological_process owl:Class GO:0010719 biolink:NamedThing negative regulation of epithelial to mesenchymal transition Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0010782 biolink:NamedThing proboscis morphogenesis, labial disc-derived The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0009886 biolink:NamedThing post-embryonic animal morphogenesis The process, occurring after animal embryonic development, by which anatomical structures are generated and organized. tmpzr1t_l9r_go_relaxed.owl post-embryonic morphogenesis of an anatomical structure biological_process owl:Class GO:0008340 biolink:NamedThing determination of adult lifespan The control of viability and duration in the adult phase of the life-cycle. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0052162 biolink:NamedThing modulation by symbiont of defense-related host calcium ion flux Any process in which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction|modulation by organism of defense-related host Ca2+ flux GO:0052301 biological_process owl:Class GO:0052031 biolink:NamedThing modulation by symbiont of host defense response Any process in which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl modulation by organism of defense response of other organism involved in symbiotic interaction|pathogenesis|mitigation by symbiont of host defense response GO:0052255 biological_process owl:Class GO:2000279 biolink:NamedThing negative regulation of DNA biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. tmpzr1t_l9r_go_relaxed.owl negative regulation of DNA synthesis|negative regulation of DNA anabolism|negative regulation of DNA formation|negative regulation of DNA biosynthesis yaf 2010-12-08T04:48:20Z biological_process owl:Class GO:2000278 biolink:NamedThing regulation of DNA biosynthetic process Any process that modulates the frequency, rate or extent of DNA biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of DNA formation|regulation of DNA synthesis|regulation of DNA biosynthesis|regulation of DNA anabolism yaf 2010-12-08T04:48:15Z biological_process owl:Class GO:0002644 biolink:NamedThing negative regulation of tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction. tmpzr1t_l9r_go_relaxed.owl inhibition of tolerance induction|down-regulation of tolerance induction|downregulation of tolerance induction|down regulation of tolerance induction biological_process owl:Class GO:0051093 biolink:NamedThing negative regulation of developmental process Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). tmpzr1t_l9r_go_relaxed.owl downregulation of developmental process|inhibition of developmental process|down-regulation of developmental process|down regulation of developmental process biological_process owl:Class GO:0004962 biolink:NamedThing endothelin receptor activity Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. tmpzr1t_l9r_go_relaxed.owl endothelin-B receptor activity|endothelin-A receptor activity GO:0001599|GO:0001600 molecular_function owl:Class GO:0008528 biolink:NamedThing G protein-coupled peptide receptor activity Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. tmpzr1t_l9r_go_relaxed.owl peptide receptor activity, G protein coupled|G protein coupled peptide receptor activity|peptide receptor activity, G-protein coupled|G-protein coupled peptide receptor activity molecular_function owl:Class GO:1903543 biolink:NamedThing positive regulation of exosomal secretion Any process that activates or increases the frequency, rate or extent of exosomal secretion. tmpzr1t_l9r_go_relaxed.owl activation of exosomal secretion|up regulation of exosomal secretion|activation of exosomal secretory pathway|up regulation of secretion of exosome|upregulation of exosomal secretory pathway|activation of secretion of exosome|up regulation of extracellular vesicular exosome secretion|upregulation of extracellular vesicular exosome secretion|up-regulation of exosomal secretory pathway|positive regulation of exosomal protein secretion|activation of extracellular vesicular exosome secretion|positive regulation of extracellular vesicular exosome secretion|up regulation of exosomal protein secretion|upregulation of exosomal secretion|upregulation of exosomal protein secretion|activation of exosomal protein secretion|upregulation of secretion of exosome|positive regulation of secretion of exosome|up-regulation of exosomal secretion|up regulation of exosomal secretory pathway|up-regulation of secretion of exosome|up-regulation of exosomal protein secretion|up-regulation of extracellular vesicular exosome secretion|positive regulation of exosomal secretory pathway pga 2014-10-14T11:39:10Z biological_process owl:Class GO:1903541 biolink:NamedThing regulation of exosomal secretion Any process that modulates the frequency, rate or extent of exosomal secretion. tmpzr1t_l9r_go_relaxed.owl regulation of exosomal protein secretion|regulation of extracellular vesicular exosome secretion|regulation of exosomal secretory pathway|regulation of secretion of exosome pga 2014-10-14T11:38:52Z biological_process owl:Class GO:1903365 biolink:NamedThing regulation of fear response Any process that modulates the frequency, rate or extent of fear response. tmpzr1t_l9r_go_relaxed.owl regulation of physiological fear response mr 2014-08-21T23:21:36Z biological_process owl:Class GO:0007058 biolink:NamedThing spindle assembly involved in female meiosis II The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. tmpzr1t_l9r_go_relaxed.owl female meiosis II spindle assembly biological_process owl:Class GO:0051225 biolink:NamedThing spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. tmpzr1t_l9r_go_relaxed.owl bipolar spindle biosynthesis|spindle formation|bipolar spindle formation|spindle biosynthesis GO:0051226|GO:0051227 biological_process owl:Class GO:0099553 biolink:NamedThing trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse. tmpzr1t_l9r_go_relaxed.owl Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class GO:0099552 biolink:NamedThing trans-synaptic signaling by lipid, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. tmpzr1t_l9r_go_relaxed.owl Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class GO:0150011 biolink:NamedThing regulation of neuron projection arborization Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. tmpzr1t_l9r_go_relaxed.owl regulation of neurite arborization|regulation of neuron projection branching|regulation of neurite branching bc 2017-12-13T16:32:34Z biological_process owl:Class GO:0031344 biolink:NamedThing regulation of cell projection organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. tmpzr1t_l9r_go_relaxed.owl regulation of cell projection organisation|regulation of cell projection organization and biogenesis biological_process owl:Class GO:0002273 biolink:NamedThing plasmacytoid dendritic cell differentiation The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0002270 biolink:NamedThing plasmacytoid dendritic cell activation A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0046450 biolink:NamedThing dethiobiotin metabolic process The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms. tmpzr1t_l9r_go_relaxed.owl desthiobiotin metabolic process|desthiobiotin metabolism|dethiobiotin metabolism biological_process owl:Class GO:1901360 biolink:NamedThing organic cyclic compound metabolic process The chemical reactions and pathways involving organic cyclic compound. tmpzr1t_l9r_go_relaxed.owl organic cyclic compound metabolism bf 2012-09-14T09:03:51Z biological_process owl:Class GO:1900980 biolink:NamedThing regulation of phenazine biosynthetic process Any process that modulates the frequency, rate or extent of phenazine biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of dibenzopyrazine biosynthesis|regulation of dibenzo-p-diazine biosynthesis|regulation of dibenzopyrazine biosynthetic process|regulation of azophenylene biosynthesis|regulation of azophenylene biosynthetic process|regulation of acridizine biosynthesis|regulation of acridizine biosynthetic process|regulation of dibenzo-p-diazine biosynthetic process tt 2012-06-14T04:04:39Z biological_process owl:Class GO:1905215 biolink:NamedThing negative regulation of RNA binding Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding. tmpzr1t_l9r_go_relaxed.owl down-regulation of RNA binding|inhibition of RNA binding|down regulation of RNA binding|downregulation of RNA binding bf 2016-06-06T10:21:04Z biological_process owl:Class GO:0033989 biolink:NamedThing 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O. tmpzr1t_l9r_go_relaxed.owl (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity|46 kDa hydratase 2 activity|(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity|D-3-hydroxyacyl-CoA dehydratase activity EC:4.2.1.107|Reactome:R-HSA-193535|Reactome:R-HSA-192331|MetaCyc:4.2.1.107-RXN|RHEA:18933 molecular_function owl:Class GO:0016836 biolink:NamedThing hydro-lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. tmpzr1t_l9r_go_relaxed.owl EC:4.2.1.-|Reactome:R-HSA-9014627 molecular_function owl:Class GO:1900095 biolink:NamedThing regulation of dosage compensation by inactivation of X chromosome Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome. tmpzr1t_l9r_go_relaxed.owl regulation of Barr body formation|regulation of X chromosome inactivation|regulation of chromosome inactivation hjd 2012-02-14T07:29:45Z biological_process owl:Class GO:0010468 biolink:NamedThing regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. tmpzr1t_l9r_go_relaxed.owl regulation of gene product expression|gene regulation|regulation of protein expression Wikipedia:Regulation_of_gene_expression This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. biological_process owl:Class GO:1905002 biolink:NamedThing positive regulation of membrane repolarization during atrial cardiac muscle cell action potential Any process that activates or increases the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential. tmpzr1t_l9r_go_relaxed.owl up regulation of electrocardiogram QRS complex|upregulation of electrocardiogram QRS complex|upregulation of membrane repolarization during atrial cardiac muscle cell action potential|positive regulation of atrial repolarization|activation of membrane repolarization during atrial cardiac muscle cell action potential|up-regulation of electrocardiogram QRS complex|upregulation of atrial repolarization|up regulation of membrane repolarization during atrial cardiac muscle cell action potential|activation of atrial repolarization|up-regulation of atrial repolarization|activation of electrocardiogram QRS complex|up regulation of atrial repolarization|up-regulation of membrane repolarization during atrial cardiac muscle cell action potential|positive regulation of electrocardiogram QRS complex rph 2016-03-01T13:28:21Z biological_process owl:Class GO:0016926 biolink:NamedThing protein desumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. tmpzr1t_l9r_go_relaxed.owl protein desumolation|desumoylation GO:0016928 biological_process owl:Class GO:0018205 biolink:NamedThing peptidyl-lysine modification The modification of peptidyl-lysine. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1900161 biolink:NamedThing regulation of phospholipid scramblase activity Any process that modulates the frequency, rate or extent of phospholipid scramblase activity. tmpzr1t_l9r_go_relaxed.owl rph 2012-03-08T10:57:19Z biological_process owl:Class GO:0061091 biolink:NamedThing regulation of phospholipid translocation Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. tmpzr1t_l9r_go_relaxed.owl dph 2010-04-26T01:54:22Z biological_process owl:Class GO:0150063 biolink:NamedThing visual system development The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. tmpzr1t_l9r_go_relaxed.owl visual pathway development|optic pathway development bc 2018-07-23T10:31:58Z biological_process owl:Class GO:0048880 biolink:NamedThing sensory system development The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0099183 biolink:NamedThing trans-synaptic signaling by BDNF, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse. tmpzr1t_l9r_go_relaxed.owl Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. dos 2017-12-01T18:25:24Z biological_process owl:Class GO:0099550 biolink:NamedThing trans-synaptic signaling, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. tmpzr1t_l9r_go_relaxed.owl Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class GO:1900141 biolink:NamedThing regulation of oligodendrocyte apoptotic process Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process. tmpzr1t_l9r_go_relaxed.owl regulation of oligodendrocyte apoptosis yaf 2012-03-06T10:22:45Z biological_process owl:Class GO:0034350 biolink:NamedThing regulation of glial cell apoptotic process Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. tmpzr1t_l9r_go_relaxed.owl regulation of glial cell apoptosis biological_process owl:Class GO:0042867 biolink:NamedThing pyruvate catabolic process The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate. tmpzr1t_l9r_go_relaxed.owl pyruvate catabolism|pyruvate degradation|pyruvate breakdown biological_process owl:Class GO:0072329 biolink:NamedThing monocarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. tmpzr1t_l9r_go_relaxed.owl mah 2010-11-02T04:41:55Z biological_process owl:Class GO:0002094 biolink:NamedThing polyprenyltransferase activity Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0004659 biolink:NamedThing prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-6806674|MetaCyc:GPPSYN-RXN molecular_function owl:Class GO:1900999 biolink:NamedThing nitrobenzene biosynthetic process The chemical reactions and pathways resulting in the formation of nitrobenzene. tmpzr1t_l9r_go_relaxed.owl nitrobenzene formation|nitrobenzene biosynthesis|nitrobenzene synthesis|nitrobenzene anabolism yaf 2012-06-14T02:54:32Z biological_process owl:Class GO:0019438 biolink:NamedThing aromatic compound biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. tmpzr1t_l9r_go_relaxed.owl aromatic compound biosynthesis|aromatic compound formation|aromatic compound anabolism|aromatic hydrocarbon biosynthesis|aromatic hydrocarbon biosynthetic process|aromatic compound synthesis biological_process owl:Class GO:0051674 biolink:NamedThing localization of cell Any process in which a cell is transported to, and/or maintained in, a specific location. tmpzr1t_l9r_go_relaxed.owl establishment and maintenance of cell localization|cell localization|establishment and maintenance of localization of cell|localisation of cell biological_process owl:Class GO:0009987 biolink:NamedThing cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. tmpzr1t_l9r_go_relaxed.owl single-organism cellular process|cell growth and/or maintenance|cellular physiological process|cell physiology jl 2012-12-11T16:56:55Z GO:0044763|GO:0050875|GO:0008151 biological_process owl:Class GO:0042923 biolink:NamedThing neuropeptide binding Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0042277 biolink:NamedThing peptide binding Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0099066 biolink:NamedThing integral component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0031301 biolink:NamedThing integral component of organelle membrane The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. tmpzr1t_l9r_go_relaxed.owl integral to organelle membrane cellular_component owl:Class GO:0034835 biolink:NamedThing 2-mercaptobenzothiazole monooxygenase activity Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole. tmpzr1t_l9r_go_relaxed.owl UM-BBD_reactionID:r1178|EC:1.13.12.- molecular_function owl:Class GO:0016703 biolink:NamedThing oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor. tmpzr1t_l9r_go_relaxed.owl EC:1.13.12.- molecular_function owl:Class GO:1903201 biolink:NamedThing regulation of oxidative stress-induced cell death Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. tmpzr1t_l9r_go_relaxed.owl regulation of cell death in response to oxidative stress bf 2014-07-21T16:10:30Z biological_process owl:Class GO:1901094 biolink:NamedThing negative regulation of protein homotetramerization Any process that stops, prevents or reduces the frequency, rate or extent of protein homotetramerization. tmpzr1t_l9r_go_relaxed.owl down-regulation of protein homotetramer assembly|inhibition of protein homotetramer assembly|down-regulation of protein homotetramer biosynthetic process|down regulation of protein homotetramer formation|down regulation of protein homotetramer assembly|inhibition of protein homotetramer formation|down-regulation of protein homotetramerization|negative regulation of protein homotetramer formation|downregulation of protein homotetramer formation|downregulation of protein homotetramer assembly|inhibition of protein homotetramer biosynthetic process|inhibition of protein homotetramerization|negative regulation of protein homotetramer biosynthetic process|down-regulation of protein homotetramer formation|down-regulation of protein homotetramer biosynthesis|down regulation of protein homotetramerization|inhibition of protein homotetramer biosynthesis|downregulation of protein homotetramer biosynthesis|negative regulation of protein homotetramer biosynthesis|down regulation of protein homotetramer biosynthesis|downregulation of protein homotetramer biosynthetic process|negative regulation of protein homotetramer assembly|downregulation of protein homotetramerization|down regulation of protein homotetramer biosynthetic process pm 2012-07-06T12:57:58Z biological_process owl:Class GO:0032463 biolink:NamedThing negative regulation of protein homooligomerization Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization. tmpzr1t_l9r_go_relaxed.owl downregulation of protein homooligomerization|inhibition of protein homooligomerization|down-regulation of protein homooligomerization|down regulation of protein homooligomerization biological_process owl:Class GO:0048754 biolink:NamedThing branching morphogenesis of an epithelial tube The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. tmpzr1t_l9r_go_relaxed.owl tubulogenesis biological_process owl:Class GO:0061138 biolink:NamedThing morphogenesis of a branching epithelium The process in which the anatomical structures of a branched epithelium are generated and organized. tmpzr1t_l9r_go_relaxed.owl dph 2010-05-25T09:05:34Z biological_process owl:Class GO:0034246 biolink:NamedThing mitochondrial transcription factor activity Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase. tmpzr1t_l9r_go_relaxed.owl mitochondrial RNA polymerase binding promoter specificity activity|mitochondrial RNA polymerase promoter specificity activity|mitochondrial transcription initiation factor activity|mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding|transcription factor activity, mitochondrial RNA polymerase core promoter sequence-specific DNA binding|mitochondrial sequence-specific DNA binding transcription factor activity|transcription factor activity, mitochondrial proximal promoter sequence-specific binding|mitochondrial polymerase transcription factor activity|mitochondrial sequence-specific DNA-binding transcription factor activity|mitochondrial DNA-binding transcription factor activity|transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding|mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity|mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity https://github.com/geneontology/go-ontology/issues/14908|https://github.com/geneontology/go-ontology/issues/19891 krc 2011-01-27T01:55:21Z GO:0000998|GO:0001142|GO:0001144|GO:0001143 molecular_function owl:Class GO:0003700 biolink:NamedThing DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. tmpzr1t_l9r_go_relaxed.owl sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity|metal ion regulated sequence-specific DNA binding transcription factor activity|transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding|bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding|transcription factor activity, metal ion regulated sequence-specific DNA binding|bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding|transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity|bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity|metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity|nucleic acid binding transcription factor activity|DNA binding transcription factor activity|gene-specific transcription factor activity|transcription factor activity|bacterial-type DNA binding transcription factor activity|transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding https://github.com/geneontology/go-ontology/issues/16534|https://github.com/geneontology/go-ontology/issues/15704|https://github.com/geneontology/go-ontology/issues/20253 Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions. krc 2010-10-21T04:37:54Z GO:0001204|GO:0001151|GO:0001199|GO:0001131|GO:0000130|GO:0001130|GO:0001071 molecular_function owl:Class GO:0060349 biolink:NamedThing bone morphogenesis The process in which bones are generated and organized. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0009887 biolink:NamedThing animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. tmpzr1t_l9r_go_relaxed.owl histogenesis and organogenesis biological_process owl:Class GO:0009167 biolink:NamedThing purine ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. tmpzr1t_l9r_go_relaxed.owl purine ribonucleoside monophosphate metabolism biological_process owl:Class GO:0009161 biolink:NamedThing ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. tmpzr1t_l9r_go_relaxed.owl ribonucleoside monophosphate metabolism biological_process owl:Class GO:0035075 biolink:NamedThing response to ecdysone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0036314 biolink:NamedThing response to sterol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. tmpzr1t_l9r_go_relaxed.owl bf 2012-08-21T14:50:14Z biological_process owl:Class GO:0002935 biolink:NamedThing tRNA (adenine-C2-)-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA. tmpzr1t_l9r_go_relaxed.owl hjd 2012-09-04T14:39:56Z molecular_function owl:Class GO:0008169 biolink:NamedThing C-methyltransferase activity Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule. tmpzr1t_l9r_go_relaxed.owl EC:2.1.1.- molecular_function owl:Class GO:0047961 biolink:NamedThing glycine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. tmpzr1t_l9r_go_relaxed.owl glycine acyltransferase activity|acyl-CoA:glycine N-acyltransferase activity|glycine-N-acylase activity Reactome:R-HSA-2534040|RHEA:19869|MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN|EC:2.3.1.13 molecular_function owl:Class GO:0016410 biolink:NamedThing N-acyltransferase activity Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-177160 molecular_function owl:Class GO:0061419 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. tmpzr1t_l9r_go_relaxed.owl dph 2012-01-23T01:07:43Z biological_process owl:Class GO:0061418 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to hypoxia Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. tmpzr1t_l9r_go_relaxed.owl dph 2012-01-23T01:05:59Z biological_process owl:Class GO:1900724 biolink:NamedThing positive regulation of protein adenylylation Any process that activates or increases the frequency, rate or extent of protein adenylylation. tmpzr1t_l9r_go_relaxed.owl upregulation of protein adenylylation|up regulation of protein amino acid adenylylation|up-regulation of protein amino acid adenylylation|up-regulation of protein adenylation|up regulation of protein AMPylation|up-regulation of protein adenylylation|positive regulation of protein AMPylation|positive regulation of protein amino acid adenylylation|up regulation of protein adenylation|upregulation of protein AMPylation|up-regulation of protein AMPylation|activation of protein adenylylation|activation of protein AMPylation|upregulation of protein amino acid adenylylation|activation of protein amino acid adenylylation|up regulation of protein adenylylation|activation of protein adenylation|upregulation of protein adenylation|positive regulation of protein adenylation jl 2012-05-24T03:16:13Z biological_process owl:Class GO:1905865 biolink:NamedThing negative regulation of Atg1/ULK1 kinase complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of Atg1/ULK1 kinase complex assembly. tmpzr1t_l9r_go_relaxed.owl downregulation of ATG1/ULK1 kinase complex formation|down-regulation of ULK1 signaling complex formation|down-regulation of ATG1/ULK1 kinase complex formation|inhibition of ATG1/ULK1 kinase complex formation|down-regulation of ATG1-ATG13 complex formation|down regulation of Atg1p signalling complex formation|down regulation of Atg1p signalling complex assembly|negative regulation of ULK1-ATG13-FIP200 complex assembly|inhibition of ATG1/ULK1 signaling complex formation|down-regulation of Atg1p signalling complex formation|down-regulation of ATG1/ULK1 signaling complex assembly|down regulation of ULK1 signaling complex assembly|down-regulation of ATG1/ULK1 kinase complex assembly|downregulation of Atg1p signalling complex assembly|negative regulation of Atg1p signalling complex assembly|negative regulation of ULK1 signaling complex formation|down-regulation of ULK1-ATG13-RB1CC1 complex formation|down regulation of ATG1/ULK1 signaling complex formation|inhibition of ATG1-ATG13 complex assembly|negative regulation of Atg1p signalling complex formation|down-regulation of ATG1 kinase complex assembly|negative regulation of ATG1-ATG13 complex formation|inhibition of ULK1 signaling complex assembly|downregulation of ATG1-ATG13 complex assembly|inhibition of ULK1-ATG13-FIP200 complex formation|down regulation of ATG1/ULK1 signaling complex assembly|inhibition of ATG1 kinase complex formation|down-regulation of Atg1p signalling complex assembly|down regulation of ATG1 kinase complex assembly|down regulation of ULK1-ATG13-RB1CC1 complex assembly|down regulation of ATG1-ATG13 complex assembly|down regulation of ULK1-ATG13-FIP200 complex formation|downregulation of ULK1-ATG13-RB1CC1 complex assembly|negative regulation of ATG1/ULK1 signaling complex formation|negative regulation of ATG1/ULK1 signaling complex assembly|down-regulation of ATG1/ULK1 signaling complex formation|down-regulation of ULK1 signaling complex assembly|down-regulation of ULK1-ATG13-RB1CC1 complex assembly|negative regulation of ULK1-ATG13-RB1CC1 complex formation|downregulation of ULK1-ATG13-FIP200 complex formation|inhibition of ATG1 kinase complex assembly|down regulation of ULK1 signaling complex formation|inhibition of ATG1/ULK1 kinase complex assembly|negative regulation of ULK1-ATG13-RB1CC1 complex assembly|down-regulation of ULK1-ATG13-FIP200 complex assembly|negative regulation of ATG1 kinase complex assembly|downregulation of ATG1 kinase complex formation|negative regulation of ATG1 kinase complex formation|downregulation of ATG1/ULK1 signaling complex assembly|negative regulation of ULK1 signaling complex assembly|downregulation of ULK1 signaling complex assembly|downregulation of ATG1 kinase complex assembly|downregulation of ATG1-ATG13 complex formation|negative regulation of ATG1-ATG13 complex assembly|inhibition of ATG1/ULK1 signaling complex assembly|downregulation of ULK1-ATG13-FIP200 complex assembly|negative regulation of ATG1/ULK1 kinase complex formation|inhibition of ATG1-ATG13 complex formation|downregulation of ATG1/ULK1 signaling complex formation|inhibition of ULK1-ATG13-RB1CC1 complex formation|downregulation of ULK1-ATG13-RB1CC1 complex formation|down regulation of ULK1-ATG13-RB1CC1 complex formation|down regulation of ATG1/ULK1 kinase complex assembly|down regulation of ATG1 kinase complex formation|inhibition of ULK1-ATG13-FIP200 complex assembly|inhibition of ULK1 signaling complex formation|down regulation of ULK1-ATG13-FIP200 complex assembly|downregulation of Atg1p signalling complex formation|downregulation of ULK1 signaling complex formation|down-regulation of ATG1-ATG13 complex assembly|down-regulation of ATG1 kinase complex formation|down regulation of ATG1-ATG13 complex formation|inhibition of Atg1p signalling complex assembly|down regulation of ATG1/ULK1 kinase complex formation|inhibition of ULK1-ATG13-RB1CC1 complex assembly|inhibition of Atg1p signalling complex formation|down-regulation of ULK1-ATG13-FIP200 complex formation|downregulation of ATG1/ULK1 kinase complex assembly|negative regulation of ULK1-ATG13-FIP200 complex formation pr 2017-01-26T13:23:35Z biological_process owl:Class GO:0043791 biolink:NamedThing dimethylamine methyltransferase activity Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine. tmpzr1t_l9r_go_relaxed.owl dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity|DMAMT 1|dimethylamine:corrinoid methyltransferase activity|mtbB1|DMA methyltransferase 1|MT1 MetaCyc:RXN-8100|EC:2.1.1.249|RHEA:41175 This function is the first step in the pathway of methanogenesis from dimethylamine. molecular_function owl:Class GO:0008168 biolink:NamedThing methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule. tmpzr1t_l9r_go_relaxed.owl methylase Reactome:R-HSA-212269|Reactome:R-HSA-71286|EC:2.1.1.-|Reactome:R-HSA-6800149|Reactome:R-HSA-379464|Reactome:R-HSA-379387 GO:0004480 molecular_function owl:Class GO:0061281 biolink:NamedThing specification of mesonephric connecting tubule identity The process in which the connecting tubule of the mesonephric nephron acquires its identity. tmpzr1t_l9r_go_relaxed.owl specification of mesonephric collecting tubule identity dph 2010-09-02T01:26:09Z biological_process owl:Class GO:0061282 biolink:NamedThing specification of mesonephric nephron tubule identity The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity. tmpzr1t_l9r_go_relaxed.owl dph 2010-09-02T01:37:44Z biological_process owl:Class GO:0033944 biolink:NamedThing beta-galactofuranosidase activity Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose. tmpzr1t_l9r_go_relaxed.owl exo-beta-galactofuranosidase activity|beta-D-galactofuranosidase activity|exo-beta-D-galactofuranosidase activity|beta-D-galactofuranoside hydrolase activity MetaCyc:3.2.1.146-RXN|EC:3.2.1.146 molecular_function owl:Class GO:0004553 biolink:NamedThing hydrolase activity, hydrolyzing O-glycosyl compounds Catalysis of the hydrolysis of any O-glycosyl bond. tmpzr1t_l9r_go_relaxed.owl O-glucosyl hydrolase activity Reactome:R-HSA-6786652|Reactome:R-HSA-9661820|Reactome:R-HSA-5694563|EC:3.2.1.- GO:0016800 molecular_function owl:Class GO:0039517 biolink:NamedThing modulation by virus of host protein serine/threonine phosphatase activity The process in which a virus effects a change in host protein serine/threonine phosphatase activity. tmpzr1t_l9r_go_relaxed.owl regulation by virus of host protein serine/threonine phosphatase activity|modulation by virus of protein serine/threonine phosphatase activity in host bf 2011-06-16T03:04:14Z biological_process owl:Class GO:0019054 biolink:NamedThing modulation by virus of host cellular process The process in which a virus effects a change in the processes and activities of its host organism. tmpzr1t_l9r_go_relaxed.owl regulation by virus of host cellular process|modulation of cellular process in host by virus|modification by virus of host cellular process|regulation of host cellular process by virus|regulation of cellular process in host by virus|modulation by virus of host process|viral host cell process manipulation biological_process owl:Class GO:2000901 biolink:NamedThing cyclodextrin catabolic process The chemical reactions and pathways resulting in the breakdown of a cyclodextrin. tmpzr1t_l9r_go_relaxed.owl cyclodextrin catabolism jl 2011-07-28T03:19:13Z biological_process owl:Class GO:0009313 biolink:NamedThing oligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. tmpzr1t_l9r_go_relaxed.owl oligosaccharide breakdown|multicellular organismal oligosaccharide catabolic process|oligosaccharide degradation|oligosaccharide catabolism GO:0051689 biological_process owl:Class GO:0014007 biolink:NamedThing negative regulation of microglia differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell. tmpzr1t_l9r_go_relaxed.owl negative regulation of microglial cell differentiation|inhibition of microglia differentiation|downregulation of microglia differentiation|down-regulation of microglia differentiation|down regulation of microglia differentiation biological_process owl:Class GO:0051033 biolink:NamedThing RNA transmembrane transporter activity Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-203906 molecular_function owl:Class GO:0051032 biolink:NamedThing nucleic acid transmembrane transporter activity Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0098940 biolink:NamedThing anterograde trans-synaptic signaling by nitric oxide Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0099548 biolink:NamedThing trans-synaptic signaling by nitric oxide Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0019418 biolink:NamedThing sulfide oxidation The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate. tmpzr1t_l9r_go_relaxed.owl sulphide oxidation MetaCyc:P222-PWY biological_process owl:Class GO:0006790 biolink:NamedThing sulfur compound metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. tmpzr1t_l9r_go_relaxed.owl sulphur metabolism|sulphur metabolic process|sulfur metabolism Wikipedia:Sulfur_metabolism biological_process owl:Class GO:0000979 biolink:NamedThing RNA polymerase II core promoter sequence-specific DNA binding Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. tmpzr1t_l9r_go_relaxed.owl krc 2010-08-10T02:17:28Z molecular_function owl:Class GO:0000977 biolink:NamedThing RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. tmpzr1t_l9r_go_relaxed.owl RNA polymerase II regulatory region DNA binding https://github.com/geneontology/go-ontology/issues/19312 To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. krc 2010-08-10T11:05:36Z GO:0001012 molecular_function owl:Class GO:0060785 biolink:NamedThing regulation of apoptosis involved in tissue homeostasis Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue. tmpzr1t_l9r_go_relaxed.owl dph 2009-07-31T01:49:54Z biological_process owl:Class GO:0060223 biolink:NamedThing retinal rod cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0060220 biolink:NamedThing camera-type eye photoreceptor cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0015754 biolink:NamedThing allose transmembrane transport The process in which allose is transported across a lipid bilayer, from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. tmpzr1t_l9r_go_relaxed.owl allose transport biological_process owl:Class GO:0008645 biolink:NamedThing hexose transmembrane transport The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. tmpzr1t_l9r_go_relaxed.owl hexose transport|hexose membrane transport|high-affinity hexose transport|low-affinity hexose transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-08T10:27:23Z GO:0008647|GO:0008646|GO:0035428 biological_process owl:Class GO:2000829 biolink:NamedThing negative regulation of parathyroid hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion. tmpzr1t_l9r_go_relaxed.owl negative regulation of parathormone secretion|negative regulation of PTH secretion|negative regulation of parathyrin secretion bf 2011-07-26T08:37:57Z biological_process owl:Class GO:0051241 biolink:NamedThing negative regulation of multicellular organismal process Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. tmpzr1t_l9r_go_relaxed.owl downregulation of multicellular organismal process|down regulation of multicellular organismal process|inhibition of multicellular organismal process|down-regulation of multicellular organismal process biological_process owl:Class GO:1905559 biolink:NamedThing positive regulation of mitotic nuclear envelope disassembly Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. tmpzr1t_l9r_go_relaxed.owl up regulation of mitotic nuclear envelope disassembly|up-regulation of mitotic nuclear envelope breakdown|up-regulation of mitotic nuclear envelope degradation|up regulation of mitotic nuclear envelope degradation|upregulation of mitotic nuclear envelope breakdown|positive regulation of mitotic nuclear envelope catabolism|up-regulation of mitotic nuclear envelope catabolism|upregulation of mitotic nuclear envelope catabolism|upregulation of mitotic nuclear envelope disassembly|activation of mitotic nuclear envelope degradation|activation of mitotic nuclear envelope breakdown|positive regulation of mitotic nuclear envelope breakdown|upregulation of mitotic nuclear envelope degradation|positive regulation of mitotic nuclear envelope degradation|up regulation of mitotic nuclear envelope breakdown|activation of mitotic nuclear envelope catabolism|up-regulation of mitotic nuclear envelope disassembly|activation of mitotic nuclear envelope disassembly|up regulation of mitotic nuclear envelope catabolism hbye 2016-10-14T13:15:17Z biological_process owl:Class GO:1905557 biolink:NamedThing regulation of mitotic nuclear envelope disassembly Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. tmpzr1t_l9r_go_relaxed.owl regulation of mitotic nuclear envelope breakdown|regulation of mitotic nuclear envelope catabolism|regulation of mitotic nuclear envelope degradation hbye 2016-10-14T13:14:57Z biological_process owl:Class GO:1902963 biolink:NamedThing negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. tmpzr1t_l9r_go_relaxed.owl down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|negative regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|downregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|inhibition of metalloendoproteinase activity involved in APP catabolic process|negative regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|down regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|down-regulation of metalloendoproteinase activity involved in APP catabolic process|downregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|inhibition of metalloendoproteinase activity involved in amyloid precursor protein breakdown|inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolism|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|negative regulation of metalloendopeptidase activity involved in APP catabolism|down-regulation of metalloendopeptidase activity involved in APP catabolism|down regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|inhibition of metalloendoprotease activity involved in APP catabolic process|negative regulation of metalloendoproteinase activity involved in APP catabolic process|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolic process|inhibition of metalloendoprotease activity involved in amyloid precursor protein degradation|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|down regulation of metalloendoprotease activity involved in APP catabolism|down regulation of metalloendoproteinase activity involved in APP catabolism|down regulation of metalloendoproteinase activity involved in APP catabolic process|down-regulation of metalloendopeptidase activity involved in APP catabolic process|inhibition of metalloendoprotease activity involved in amyloid precursor protein breakdown|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|down regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|downregulation of metalloendoprotease activity involved in APP catabolism|inhibition of metalloendoprotease activity involved in APP catabolism|downregulation of metalloendopeptidase activity involved in APP catabolism|negative regulation of metalloendoprotease activity involved in APP catabolism|downregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|negative regulation of metalloendoproteinase activity involved in APP catabolism|downregulation of metalloendoprotease activity involved in APP catabolic process|negative regulation of metalloendoprotease activity involved in APP catabolic process|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|inhibition of metalloendopeptidase activity involved in amyloid precursor protein breakdown|negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoproteinase activity involved in APP catabolism|inhibition of metalloendoproteinase activity involved in APP catabolism|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|down-regulation of metalloendoprotease activity involved in APP catabolism|inhibition of metalloendopeptidase activity involved in amyloid precursor protein degradation|downregulation of metalloendopeptidase activity involved in APP catabolic process|downregulation of metalloendoproteinase activity involved in APP catabolism|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|inhibition of metalloendopeptidase activity involved in APP catabolism|downregulation of metalloendoproteinase activity involved in APP catabolic process|inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|downregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|down regulation of metalloendopeptidase activity involved in APP catabolism|negative regulation of metalloendopeptidase activity involved in APP catabolic process|down regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|down regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|inhibition of metalloendopeptidase activity involved in APP catabolic process|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoprotease activity involved in APP catabolic process|downregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|down regulation of metalloendopeptidase activity involved in APP catabolic process|downregulation of metalloendoprotease activity involved in amyloid precursor protein degradation|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|inhibition of metalloendoproteinase activity involved in amyloid precursor protein degradation|down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|down regulation of metalloendoprotease activity involved in APP catabolic process|downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|down regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|down-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation sjp 2014-05-06T09:12:01Z biological_process owl:Class GO:1902992 biolink:NamedThing negative regulation of amyloid precursor protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process. tmpzr1t_l9r_go_relaxed.owl negative regulation of APP catabolism|inhibition of amyloid precursor protein breakdown|down regulation of APP catabolic process|negative regulation of amyloid precursor protein breakdown|inhibition of amyloid precursor protein catabolism|down regulation of amyloid precursor protein catabolic process|down regulation of APP catabolism|inhibition of amyloid precursor protein degradation|down-regulation of amyloid precursor protein degradation|down regulation of amyloid precursor protein catabolism|negative regulation of APP catabolic process|down-regulation of amyloid precursor protein catabolism|down-regulation of amyloid precursor protein catabolic process|downregulation of amyloid precursor protein catabolic process|down-regulation of APP catabolic process|downregulation of APP catabolism|inhibition of APP catabolic process|downregulation of amyloid precursor protein degradation|down regulation of amyloid precursor protein degradation|downregulation of amyloid precursor protein catabolism|downregulation of APP catabolic process|down-regulation of amyloid precursor protein breakdown|downregulation of amyloid precursor protein breakdown|down-regulation of APP catabolism|inhibition of APP catabolism|negative regulation of amyloid precursor protein degradation|inhibition of amyloid precursor protein catabolic process|down regulation of amyloid precursor protein breakdown|negative regulation of amyloid precursor protein catabolism rl 2014-05-08T14:21:10Z biological_process owl:Class GO:0009425 biolink:NamedThing bacterial-type flagellum basal body One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. tmpzr1t_l9r_go_relaxed.owl flagellin-based flagellum basal body|flagellar basal body cellular_component owl:Class GO:0086051 biolink:NamedThing membrane repolarization during Purkinje myocyte action potential The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. tmpzr1t_l9r_go_relaxed.owl dph 2011-11-16T11:51:56Z biological_process owl:Class GO:0086013 biolink:NamedThing membrane repolarization during cardiac muscle cell action potential The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. tmpzr1t_l9r_go_relaxed.owl tb 2011-11-10T08:23:25Z biological_process owl:Class GO:0030870 biolink:NamedThing Mre11 complex Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. tmpzr1t_l9r_go_relaxed.owl RAD50-MRE11-NBN complex|RMX complex|Rad50 complex|MRN complex|Rad50-Rad32-Nbs1 complex|MRX complex cellular_component owl:Class GO:1901392 biolink:NamedThing regulation of transforming growth factor beta1 activation Any process that modulates the frequency, rate or extent of transforming growth factor beta1 activation. tmpzr1t_l9r_go_relaxed.owl regulation of TGFB1 activation|regulation of transforming growth factor-beta1 activation|regulation of L-TGF-beta 1 activation|regulation of latent-TGF-beta1 activation|regulation of TGFbeta 1 activation|regulation of TGF-beta 1 activation bf 2012-10-01T10:40:06Z biological_process owl:Class GO:0006245 biolink:NamedThing TDP catabolic process The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate. tmpzr1t_l9r_go_relaxed.owl TDP breakdown|TDP catabolism|TDP degradation biological_process owl:Class GO:0046043 biolink:NamedThing TDP metabolic process The chemical reactions and pathways involving TDP, ribosylthymine diphosphate. tmpzr1t_l9r_go_relaxed.owl TDP metabolism biological_process owl:Class GO:0018283 biolink:NamedThing iron incorporation into metallo-sulfur cluster The incorporation of iron into a metallo-sulfur cluster. tmpzr1t_l9r_go_relaxed.owl iron incorporation into metallo-sulphur cluster biological_process owl:Class GO:0016226 biolink:NamedThing iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. tmpzr1t_l9r_go_relaxed.owl iron-sulfur cluster biosynthesis|iron-sulphur cluster assembly biological_process owl:Class GO:0033246 biolink:NamedThing positive regulation of penicillin metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. tmpzr1t_l9r_go_relaxed.owl positive regulation of penicillin metabolism biological_process owl:Class GO:0034250 biolink:NamedThing positive regulation of cellular amide metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. tmpzr1t_l9r_go_relaxed.owl positive regulation of amide metabolism biological_process owl:Class GO:0047050 biolink:NamedThing (S)-2-hydroxy-fatty acid dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH. tmpzr1t_l9r_go_relaxed.owl L-2-hydroxy fatty acid dehydrogenase activity|2-hydroxy fatty acid oxidase|(S)-2-hydroxystearate:NAD+ oxidoreductase activity|dehydrogenase, L-2-hydroxy fatty acid|(S)-2-hydroxy-fatty-acid dehydrogenase activity MetaCyc:1.1.1.99-RXN|KEGG_REACTION:R03022|RHEA:11384|EC:1.1.1.99 molecular_function owl:Class GO:2000831 biolink:NamedThing regulation of steroid hormone secretion Any process that modulates the frequency, rate or extent of steroid hormone secretion. tmpzr1t_l9r_go_relaxed.owl bf 2011-07-26T08:38:46Z biological_process owl:Class GO:0097155 biolink:NamedThing fasciculation of sensory neuron axon The collection of sensory neuron axons into a bundle of rods, known as a fascicle. tmpzr1t_l9r_go_relaxed.owl pr 2011-09-16T09:17:34Z biological_process owl:Class GO:0007413 biolink:NamedThing axonal fasciculation The collection of axons into a bundle of rods, known as a fascicle. tmpzr1t_l9r_go_relaxed.owl fasciculation of neuron biological_process owl:Class GO:0070849 biolink:NamedThing response to epidermal growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. tmpzr1t_l9r_go_relaxed.owl response to EGF stimulus|response to epidermal growth factor stimulus mah 2009-08-04T04:26:26Z biological_process owl:Class GO:0070848 biolink:NamedThing response to growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. tmpzr1t_l9r_go_relaxed.owl response to growth factor stimulus mah 2009-08-04T04:24:18Z biological_process owl:Class GO:0032411 biolink:NamedThing positive regulation of transporter activity Any process that activates or increases the activity of a transporter. tmpzr1t_l9r_go_relaxed.owl up regulation of transporter activity|upregulation of transporter activity|up-regulation of transporter activity|activation of transporter activity|stimulation of transporter activity biological_process owl:Class GO:0032409 biolink:NamedThing regulation of transporter activity Any process that modulates the activity of a transporter. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1905931 biolink:NamedThing negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching. tmpzr1t_l9r_go_relaxed.owl negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|down regulation of VSMC differentiation involved in phenotypic dimorphism|inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic switching|down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|negative regulation of VSMC differentiation involved in phenotypic dimorphism|down-regulation of VSMC differentiation involved in phenotypic dimorphism|downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|down-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|inhibition of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|down-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|down regulation of VSMC differentiation involved in phenotypic switching|downregulation of vascular smooth muscle cell differentiation involved in phenotypic switching|inhibition of VSMC differentiation involved in phenotypic switching|inhibition of VSMC differentiation involved in phenotypic dimorphism|negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|downregulation of VSMC differentiation involved in phenotypic dimorphism|down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|inhibition of vascular smooth muscle cell differentiation involved in phenotypic switching|negative regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|down regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|down-regulation of VSMC differentiation involved in phenotypic switching|down regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|downregulation of VSMC differentiation involved in phenotypic switching|downregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|negative regulation of VSMC differentiation involved in phenotypic switching rph 2017-02-09T09:21:08Z biological_process owl:Class GO:1905916 biolink:NamedThing negative regulation of cell differentiation involved in phenotypic switching Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation involved in phenotypic switching. tmpzr1t_l9r_go_relaxed.owl down regulation of cell differentiation involved in phenotypic switching|inhibition of cell differentiation involved in phenotypic switching|down-regulation of cell differentiation involved in phenotypic switching|downregulation of cell differentiation involved in phenotypic switching rph 2017-02-08T12:23:23Z biological_process owl:Class GO:0061686 biolink:NamedThing hercynylcysteine sulfoxide synthase activity Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 <=> hercynylcysteine sulfoxide + H2O. tmpzr1t_l9r_go_relaxed.owl hercynylcysteine S-oxide synthase|hercynylcysteine sulfoxide synthase https://github.com/geneontology/go-ontology/issues/11163 RHEA:42704|EC:1.14.99.51 dph 2015-03-06T15:08:51Z molecular_function owl:Class GO:0016705 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. tmpzr1t_l9r_go_relaxed.owl oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous EC:1.14.-.- molecular_function owl:Class GO:0062101 biolink:NamedThing peptidyl-aspartic acid 3-dioxygenase activity Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2. tmpzr1t_l9r_go_relaxed.owl peptide-aspartate beta-dioxygenase activity|aspartate beta-hydroxylase activity|aspartyl/asparaginyl beta-hydroxylase activity|peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity|aspartylpeptide beta-dioxygenase activity https://github.com/geneontology/go-ontology/issues/17842 RHEA:11508|MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN|EC:1.14.11.16 dph 2018-12-06T14:01:15Z GO:0004597 molecular_function owl:Class GO:0016706 biolink:NamedThing 2-oxoglutarate-dependent dioxygenase activity Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. tmpzr1t_l9r_go_relaxed.owl oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|2-oxoglutarate dioxygenase activity EC:1.14.11.-|Reactome:R-HSA-6783455|Reactome:R-HSA-1234164 GO:0010302 molecular_function owl:Class GO:1902681 biolink:NamedThing regulation of replication fork arrest at rDNA repeats Any process that modulates the frequency, rate or extent of replication fork arrest at rDNA repeats. tmpzr1t_l9r_go_relaxed.owl regulation of replication fork blocking at rDNA repeats|regulation of replication fork arrest at ribosomal DNA repeats mah 2014-02-05T16:59:21Z biological_process owl:Class GO:0090329 biolink:NamedThing regulation of DNA-dependent DNA replication Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. tmpzr1t_l9r_go_relaxed.owl tb 2010-05-14T10:42:04Z biological_process owl:Class GO:0035515 biolink:NamedThing oxidative RNA demethylase activity Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. tmpzr1t_l9r_go_relaxed.owl 2-oxoglutarate-dependent RNA demethylase https://github.com/geneontology/go-ontology/issues/21160 Reactome:R-HSA-8857692 bf 2010-04-30T02:37:08Z molecular_function owl:Class GO:1905932 biolink:NamedThing positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching. tmpzr1t_l9r_go_relaxed.owl activation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|upregulation of VSMC differentiation involved in phenotypic dimorphism|positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|activation of VSMC differentiation involved in phenotypic dimorphism|up-regulation of VSMC differentiation involved in phenotypic dimorphism|upregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|up regulation of VSMC differentiation involved in phenotypic switching|up-regulation of VSMC differentiation involved in phenotypic switching|activation of vascular smooth muscle cell differentiation involved in phenotypic switching|upregulation of VSMC differentiation involved in phenotypic switching|positive regulation of VSMC differentiation involved in phenotypic dimorphism|positive regulation of VSMC differentiation involved in phenotypic switching|upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|activation of VSMC differentiation involved in phenotypic switching|upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|positive regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|up regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|up-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|up regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|activation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|upregulation of vascular smooth muscle cell differentiation involved in phenotypic switching|positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|up-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|up regulation of VSMC differentiation involved in phenotypic dimorphism|activation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism rph 2017-02-09T09:21:17Z biological_process owl:Class GO:1905065 biolink:NamedThing positive regulation of vascular associated smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. tmpzr1t_l9r_go_relaxed.owl up-regulation of vascular smooth muscle cell differentiation|upregulation of vascular associated smooth muscle cell differentiation|up regulation of vascular smooth muscle cell differentiation|up-regulation of vascular associated smooth muscle cell differentiation|up-regulation of VSMC differentiation|positive regulation of vascular smooth muscle cell differentiation|up regulation of vascular associated smooth muscle cell differentiation|activation of vascular smooth muscle cell differentiation|activation of vascular associated smooth muscle cell differentiation|upregulation of VSMC differentiation|upregulation of vascular smooth muscle cell differentiation|up regulation of VSMC differentiation|activation of VSMC differentiation|positive regulation of VSMC differentiation rph 2016-03-21T11:15:13Z biological_process owl:Class GO:0034037 biolink:NamedThing purine ribonucleoside bisphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. tmpzr1t_l9r_go_relaxed.owl purine ribonucleoside bisphosphate breakdown|purine ribonucleoside bisphosphate catabolism|purine ribonucleoside bisphosphate degradation biological_process owl:Class GO:0034034 biolink:NamedThing purine nucleoside bisphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. tmpzr1t_l9r_go_relaxed.owl purine nucleoside bisphosphate breakdown|purine nucleoside bisphosphate catabolism|purine nucleoside bisphosphate degradation biological_process owl:Class GO:0106082 biolink:NamedThing sucrose import across plasma membrane The directed movement of sucrose from outside of a cell, across the plasma membrane and into the cytosol. tmpzr1t_l9r_go_relaxed.owl hjd 2017-12-28T18:16:29Z biological_process owl:Class GO:0098704 biolink:NamedThing carbohydrate import across plasma membrane The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol. tmpzr1t_l9r_go_relaxed.owl carbohydrate import into cell pr 2012-05-31T02:45:02Z GO:0097319 biological_process owl:Class GO:0061257 biolink:NamedThing mesonephric glomerular visceral epithelial cell development The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. tmpzr1t_l9r_go_relaxed.owl dph 2010-08-30T02:10:40Z biological_process owl:Class GO:0072015 biolink:NamedThing glomerular visceral epithelial cell development The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. tmpzr1t_l9r_go_relaxed.owl podocyte development mah 2010-01-25T02:12:45Z biological_process owl:Class GO:0031032 biolink:NamedThing actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. tmpzr1t_l9r_go_relaxed.owl actomyosin organization|actomyosin structure organization and biogenesis|actomyosin structure organisation Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. biological_process owl:Class GO:0032698 biolink:NamedThing negative regulation of interleukin-15 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production. tmpzr1t_l9r_go_relaxed.owl negative regulation of interleukin-15 biosynthetic process|downregulation of interleukin-15 production|negative regulation of IL-15 production|down-regulation of interleukin-15 production|inhibition of interleukin-15 production|down regulation of interleukin-15 production GO:0045373 biological_process owl:Class GO:0001818 biolink:NamedThing negative regulation of cytokine production Any process that stops, prevents, or reduces the rate of production of a cytokine. tmpzr1t_l9r_go_relaxed.owl down regulation of cytokine production|negative regulation of cytokine formation|negative regulation of cytokine biosynthesis|negative regulation of cytokine secretion|negative regulation of cytokine synthesis|inhibition of cytokine biosynthetic process|down regulation of cytokine biosynthetic process|negative regulation of cytokine anabolism|down-regulation of cytokine production|downregulation of cytokine production|negative regulation of cytokine biosynthetic process|inhibition of cytokine production|downregulation of cytokine biosynthetic process|down-regulation of cytokine biosynthetic process GO:0050710|GO:0042036 biological_process owl:Class GO:0035639 biolink:NamedThing purine ribonucleoside triphosphate binding Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. tmpzr1t_l9r_go_relaxed.owl purine NTP binding bf 2011-01-14T02:46:42Z molecular_function owl:Class GO:1901265 biolink:NamedThing nucleoside phosphate binding Binding to nucleoside phosphate. tmpzr1t_l9r_go_relaxed.owl bf 2012-08-17T12:59:58Z molecular_function owl:Class GO:0048529 biolink:NamedThing magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. tmpzr1t_l9r_go_relaxed.owl Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity|Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity|magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating) EC:1.14.13.81|RHEA:33235 molecular_function owl:Class GO:0099583 biolink:NamedThing neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. tmpzr1t_l9r_go_relaxed.owl neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels molecular_function owl:Class GO:0098960 biolink:NamedThing postsynaptic neurotransmitter receptor activity Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission. tmpzr1t_l9r_go_relaxed.owl neurotransmitter receptor activity involved in chemical synaptic transmission molecular_function owl:Class GO:0051361 biolink:NamedThing peptide cross-linking via L-lysine 5-imidazolinone glycine The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. tmpzr1t_l9r_go_relaxed.owl biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine|biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine RESID:AA0381 See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. biological_process owl:Class GO:0018298 biolink:NamedThing protein-chromophore linkage The covalent or noncovalent attachment of a chromophore to a protein. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0103044 biolink:NamedThing ribosomal protein S6 glutamate-glutamate ligase activity Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN0-6726 molecular_function owl:Class GO:0018169 biolink:NamedThing ribosomal S6-glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0102921 biolink:NamedThing mannosylglycerate synthase activity Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate <=> H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-8849|RHEA:30639|EC:2.4.1.269 molecular_function owl:Class GO:0071797 biolink:NamedThing LUBAC complex A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex. tmpzr1t_l9r_go_relaxed.owl mah 2010-09-02T04:09:55Z cellular_component owl:Class GO:0000151 biolink:NamedThing ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0006047 biolink:NamedThing UDP-N-acetylglucosamine metabolic process The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. tmpzr1t_l9r_go_relaxed.owl UDP-N-acetylglucosamine metabolism biological_process owl:Class GO:0006793 biolink:NamedThing phosphorus metabolic process The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). tmpzr1t_l9r_go_relaxed.owl phosphorus metabolism biological_process owl:Class GO:0048578 biolink:NamedThing positive regulation of long-day photoperiodism, flowering Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. tmpzr1t_l9r_go_relaxed.owl stimulation of long-day photoperiodism, flowering|up regulation of long-day photoperiodism, flowering|activation of long-day photoperiodism, flowering|upregulation of long-day photoperiodism, flowering|up-regulation of long-day photoperiodism, flowering biological_process owl:Class GO:0048586 biolink:NamedThing regulation of long-day photoperiodism, flowering Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1905194 biolink:NamedThing positive regulation of chloroplast fission Any process that activates or increases the frequency, rate or extent of chloroplast fission. tmpzr1t_l9r_go_relaxed.owl positive regulation of chloroplast division|upregulation of chloroplast fission|up-regulation of chloroplast division|activation of chloroplast fission|up regulation of chloroplast division|activation of chloroplast division|up-regulation of chloroplast fission|up regulation of chloroplast fission|upregulation of chloroplast division Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. lr 2016-05-10T19:07:51Z biological_process owl:Class GO:1905192 biolink:NamedThing regulation of chloroplast fission Any process that modulates the frequency, rate or extent of chloroplast fission. tmpzr1t_l9r_go_relaxed.owl regulation of chloroplast division Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. lr 2016-05-10T19:07:34Z biological_process owl:Class GO:0016453 biolink:NamedThing C-acetyltransferase activity Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0016408 biolink:NamedThing C-acyltransferase activity Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:1902914 biolink:NamedThing regulation of protein polyubiquitination Any process that modulates the frequency, rate or extent of protein polyubiquitination. tmpzr1t_l9r_go_relaxed.owl regulation of protein polyubiquitylation|regulation of polyubiquitin|regulation of protein polyubiquitinylation di 2014-04-18T22:09:52Z biological_process owl:Class GO:0150152 biolink:NamedThing negative regulation of interleukin-17A production Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A production. tmpzr1t_l9r_go_relaxed.owl negative regulation of interleukin-17A biosynthetic process bc 2019-12-11T07:45:24Z biological_process owl:Class GO:0032700 biolink:NamedThing negative regulation of interleukin-17 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. tmpzr1t_l9r_go_relaxed.owl down regulation of interleukin-17 production|negative regulation of interleukin-17 secretion|negative regulation of interleukin-17 biosynthetic process|negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion|inhibition of interleukin-17 production|negative regulation of CTLA-8 production|negative regulation of IL-17 production|downregulation of interleukin-17 production GO:0045379|GO:1905077 biological_process owl:Class GO:1905627 biolink:NamedThing regulation of serotonin biosynthetic process Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of serotonin formation|regulation of serotonin synthesis|regulation of serotonin biosynthesis|regulation of serotonin anabolism pad 2016-10-31T14:26:20Z biological_process owl:Class GO:1903047 biolink:NamedThing mitotic cell cycle process A process that is part of the mitotic cell cycle. tmpzr1t_l9r_go_relaxed.owl jl 2014-05-22T14:22:34Z biological_process owl:Class GO:0060588 biolink:NamedThing negative regulation of lipoprotein lipid oxidation Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group. tmpzr1t_l9r_go_relaxed.owl dph 2009-05-08T02:30:49Z biological_process owl:Class GO:1902639 biolink:NamedThing propan-2-ol metabolic process The chemical reactions and pathways involving propan-2-ol. tmpzr1t_l9r_go_relaxed.owl Isopropanol metabolic process|Isopropyl alcohol metabolic process|propan-2-ol metabolism tt 2014-01-21T13:57:13Z biological_process owl:Class GO:1902652 biolink:NamedThing secondary alcohol metabolic process The chemical reactions and pathways involving secondary alcohol. tmpzr1t_l9r_go_relaxed.owl secondary alcohol metabolism tt 2014-01-22T10:14:52Z biological_process owl:Class GO:1904036 biolink:NamedThing negative regulation of epithelial cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. tmpzr1t_l9r_go_relaxed.owl down regulation of epithelial cell apoptotic process|down-regulation of epithelial cell apoptotic process|negative regulation of epitheliocyte apoptosis|down-regulation of epithelial cell apoptosis|down regulation of epitheliocyte apoptosis|down regulation of epitheliocyte apoptotic process|down-regulation of epitheliocyte apoptosis|downregulation of epithelial cell apoptosis|downregulation of epitheliocyte apoptosis|down regulation of epithelial cell apoptosis|inhibition of epithelial cell apoptotic process|downregulation of epitheliocyte apoptotic process|inhibition of epitheliocyte apoptotic process|down-regulation of epitheliocyte apoptotic process|inhibition of epitheliocyte apoptosis|downregulation of epithelial cell apoptotic process|negative regulation of epitheliocyte apoptotic process|inhibition of epithelial cell apoptosis|negative regulation of epithelial cell apoptosis sl 2015-03-13T22:05:47Z biological_process owl:Class GO:1904035 biolink:NamedThing regulation of epithelial cell apoptotic process Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. tmpzr1t_l9r_go_relaxed.owl regulation of epitheliocyte apoptosis|regulation of epitheliocyte apoptotic process|regulation of epithelial cell apoptosis sl 2015-03-13T22:05:41Z biological_process owl:Class GO:1901149 biolink:NamedThing salicylic acid binding Binding to salicylic acid. tmpzr1t_l9r_go_relaxed.owl salicylic acid receptor dhl 2012-07-16T05:26:38Z molecular_function owl:Class GO:0033293 biolink:NamedThing monocarboxylic acid binding Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0044257 biolink:NamedThing cellular protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by individual cells. tmpzr1t_l9r_go_relaxed.owl cellular protein breakdown|cellular protein degradation|cellular protein catabolism biological_process owl:Class GO:0044265 biolink:NamedThing cellular macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl cellular biopolymer catabolic process|cellular macromolecule degradation|cellular macromolecule breakdown|cellular macromolecule catabolism GO:0034962 biological_process owl:Class GO:1900791 biolink:NamedThing shamixanthone metabolic process The chemical reactions and pathways involving shamixanthone. tmpzr1t_l9r_go_relaxed.owl shamixanthone metabolism di 2012-06-04T09:40:20Z biological_process owl:Class GO:0042180 biolink:NamedThing cellular ketone metabolic process The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. tmpzr1t_l9r_go_relaxed.owl ketone metabolism biological_process owl:Class GO:2000573 biolink:NamedThing positive regulation of DNA biosynthetic process Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. tmpzr1t_l9r_go_relaxed.owl positive regulation of DNA biosynthesis|positive regulation of DNA formation|positive regulation of DNA anabolism|positive regulation of DNA synthesis yaf 2011-04-04T10:01:20Z biological_process owl:Class GO:0010557 biolink:NamedThing positive regulation of macromolecule biosynthetic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:2001051 biolink:NamedThing positive regulation of tendon cell differentiation Any process that activates or increases the frequency, rate or extent of tendon cell differentiation. tmpzr1t_l9r_go_relaxed.owl positive regulation of tenocyte differentiation|positive regulation of muscle attachment cell differentiation yaf 2011-09-01T09:20:42Z biological_process owl:Class GO:2001049 biolink:NamedThing regulation of tendon cell differentiation Any process that modulates the frequency, rate or extent of tendon cell differentiation. tmpzr1t_l9r_go_relaxed.owl regulation of muscle attachment cell differentiation|regulation of tenocyte differentiation yaf 2011-09-01T09:20:32Z biological_process owl:Class GO:0047542 biolink:NamedThing 2-furoyl-CoA dehydrogenase activity Catalysis of the reaction: 2-furoyl-CoA + A + H(2)O = 5-hydroxy-2-furoyl-CoA + AH(2) + H(+). tmpzr1t_l9r_go_relaxed.owl 2-furoyl coenzyme A hydroxylase activity|2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)|furoyl-CoA hydroxylase activity|2-furoyl coenzyme A dehydrogenase activity|2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating) MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN|RHEA:21480|EC:1.3.99.8|KEGG_REACTION:R02987 molecular_function owl:Class GO:0016627 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. tmpzr1t_l9r_go_relaxed.owl oxidoreductase activity, acting on the CH-CH group of donors, other acceptors Reactome:R-HSA-2995334|Reactome:R-HSA-9661710|EC:1.3.-.- molecular_function owl:Class GO:0034501 biolink:NamedThing protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore. tmpzr1t_l9r_go_relaxed.owl condensin localization to kinetochore|protein localisation to kinetochore biological_process owl:Class GO:1903083 biolink:NamedThing protein localization to condensed chromosome A process in which a protein is transported to, or maintained in, a location within a condensed chromosome. tmpzr1t_l9r_go_relaxed.owl protein localisation to condensed chromosome|protein localisation in condensed chromosome|protein localization in condensed chromosome kmv 2014-05-29T20:31:25Z biological_process owl:Class GO:0070040 biolink:NamedThing rRNA (adenine-C2-)-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-11586|EC:2.1.1.192 molecular_function owl:Class GO:0016433 biolink:NamedThing rRNA (adenine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:1902869 biolink:NamedThing regulation of amacrine cell differentiation Any process that modulates the frequency, rate or extent of amacrine cell differentiation. tmpzr1t_l9r_go_relaxed.owl regulation of amacrine neuron differentiation mr 2014-04-03T15:24:35Z biological_process owl:Class GO:0045664 biolink:NamedThing regulation of neuron differentiation Any process that modulates the frequency, rate or extent of neuron differentiation. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1904677 biolink:NamedThing positive regulation of somatic stem cell division Any process that activates or increases the frequency, rate or extent of somatic stem cell division. tmpzr1t_l9r_go_relaxed.owl positive regulation of somatic stem cell renewal|activation of somatic stem cell renewal|upregulation of somatic stem cell division|up-regulation of somatic stem cell division|up regulation of somatic stem cell division|up-regulation of somatic stem cell renewal|activation of somatic stem cell division|up regulation of somatic stem cell renewal|upregulation of somatic stem cell renewal rph 2015-09-14T08:47:34Z biological_process owl:Class GO:0051781 biolink:NamedThing positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division. tmpzr1t_l9r_go_relaxed.owl up regulation of cell division|stimulation of cell division|up-regulation of cell division|activation of cell division|upregulation of cell division biological_process owl:Class GO:0044307 biolink:NamedThing dendritic branch A dendrite arising from another dendrite. tmpzr1t_l9r_go_relaxed.owl dendrite branch|secondary dendrite NIF_Subcellular:sao884265541 jl 2010-02-05T04:18:53Z cellular_component owl:Class GO:0030425 biolink:NamedThing dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Dendrite|NIF_Subcellular:sao1211023249 cellular_component owl:Class GO:1900282 biolink:NamedThing regulation of cellobiose catabolic process Any process that modulates the frequency, rate or extent of cellobiose catabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of cellobiose catabolism tt 2012-04-05T12:28:50Z biological_process owl:Class GO:2000930 biolink:NamedThing regulation of cellobiose metabolic process Any process that modulates the frequency, rate or extent of cellobiose metabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of cellobiose metabolism tt 2011-08-01T12:42:53Z biological_process owl:Class GO:0032734 biolink:NamedThing positive regulation of interleukin-11 production Any process that activates or increases the frequency, rate, or extent of interleukin-11 production. tmpzr1t_l9r_go_relaxed.owl positive regulation of IL-11 production|positive regulation of interleukin-11 secretion|stimulation of interleukin-11 production|up regulation of interleukin-11 production|up-regulation of interleukin-11 production|positive regulation of interleukin-11 biosynthetic process|activation of interleukin-11 production|upregulation of interleukin-11 production GO:0150171|GO:0045365 biological_process owl:Class GO:0032654 biolink:NamedThing regulation of interleukin-11 production Any process that modulates the frequency, rate, or extent of interleukin-11 production. tmpzr1t_l9r_go_relaxed.owl regulation of interleukin-11 secretion|regulation of interleukin-11 biosynthetic process|regulation of IL-11 production GO:0045363|GO:0150169 biological_process owl:Class GO:0051099 biolink:NamedThing positive regulation of binding Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. tmpzr1t_l9r_go_relaxed.owl up-regulation of binding|stimulation of binding|up regulation of binding|upregulation of binding|activation of binding biological_process owl:Class GO:0048865 biolink:NamedThing stem cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0045165 biolink:NamedThing cell fate commitment The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. tmpzr1t_l9r_go_relaxed.owl Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. biological_process owl:Class GO:1902216 biolink:NamedThing positive regulation of interleukin-4-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway. tmpzr1t_l9r_go_relaxed.owl upregulation of interleukin-4-mediated signaling pathway|up-regulation of interleukin-4-mediated signalling pathway|up regulation of IL-4-mediated signaling pathway|up regulation of interleukin-4-mediated signaling pathway|activation of interleukin-4-mediated signalling pathway|up-regulation of IL-4-mediated signaling pathway|upregulation of IL-4-mediated signaling pathway|up regulation of interleukin-4-mediated signalling pathway|upregulation of interleukin-4-mediated signalling pathway|positive regulation of IL-4-mediated signaling pathway|activation of interleukin-4-mediated signaling pathway|up-regulation of interleukin-4-mediated signaling pathway|activation of IL-4-mediated signaling pathway|positive regulation of interleukin-4-mediated signalling pathway lb 2013-06-12T12:53:20Z biological_process owl:Class GO:0046089 biolink:NamedThing cytosine biosynthetic process The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. tmpzr1t_l9r_go_relaxed.owl cytosine synthesis|cytosine anabolism|cytosine formation|cytosine biosynthesis biological_process owl:Class GO:0019858 biolink:NamedThing cytosine metabolic process The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. tmpzr1t_l9r_go_relaxed.owl cytosine metabolism biological_process owl:Class GO:0030777 biolink:NamedThing (S)-scoulerine 9-O-methyltransferase activity Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+). tmpzr1t_l9r_go_relaxed.owl S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity|S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity EC:2.1.1.117|RHEA:23808|KEGG_REACTION:R03835|MetaCyc:2.1.1.117-RXN molecular_function owl:Class GO:0042862 biolink:NamedThing achromobactin catabolic process The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore. tmpzr1t_l9r_go_relaxed.owl achromobactin degradation|achromobactin breakdown|achromobactin catabolism biological_process owl:Class GO:1901616 biolink:NamedThing organic hydroxy compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. tmpzr1t_l9r_go_relaxed.owl organic hydroxy compound catabolism|organic hydroxy compound breakdown|organic hydroxy compound degradation pr 2012-11-13T12:54:31Z biological_process owl:Class GO:0102900 biolink:NamedThing dehydroabietadienal hydroxylase activity Catalysis of the reaction: dehydroabietadienal + NADPH + O2 <=> dehydroabietic acid + NADP + H2O. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-8534 molecular_function owl:Class GO:0018947 biolink:NamedThing anaerobic organosilicon metabolic process The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen. tmpzr1t_l9r_go_relaxed.owl anaerobic organosilicone metabolism|anaerobic organosilicone metabolic process|anaerobic organosilicon metabolism UM-BBD_pathwayID:osi biological_process owl:Class GO:0018945 biolink:NamedThing organosilicon metabolic process The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon. tmpzr1t_l9r_go_relaxed.owl organosilicone metabolic process|organosilicone metabolism|organosilicon metabolism UM-BBD_pathwayID:osi biological_process owl:Class GO:0102177 biolink:NamedThing 24-methylenelophenol methyl oxidase activity Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-11930|RHEA:58872|EC:1.14.18.11 molecular_function owl:Class GO:1901389 biolink:NamedThing negative regulation of transforming growth factor beta activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation. tmpzr1t_l9r_go_relaxed.owl down-regulation of TGFB activation|down regulation of TGF-beta activation|down regulation of L-TGF-beta activation|down regulation of TGFB activation|inhibition of TGF-beta activation|negative regulation of TGFbeta activation|negative regulation of TGF-beta activation|down regulation of latent TGF-beta activation|negative regulation of latent TGF-beta activation|down-regulation of transforming growth factor beta activation|downregulation of latent TGF-beta activation|downregulation of transforming growth factor beta activation|down-regulation of TGF-B activation|negative regulation of TGFB activation|inhibition of TGF-B activation|down-regulation of L-TGF-beta activation|downregulation of TGFB activation|downregulation of TGFbeta activation|inhibition of TGFB activation|down-regulation of TGF-beta activation|downregulation of TGF-beta activation|negative regulation of L-TGF-beta activation|down regulation of TGF-B activation|down regulation of TGFbeta activation|down regulation of transforming growth factor beta activation|down-regulation of TGFbeta activation|negative regulation of TGF-B activation|inhibition of L-TGF-beta activation|downregulation of TGF-B activation|inhibition of transforming growth factor beta activation|downregulation of L-TGF-beta activation|down-regulation of latent TGF-beta activation|inhibition of TGFbeta activation|inhibition of latent TGF-beta activation bf 2012-10-01T10:33:09Z biological_process owl:Class GO:1901388 biolink:NamedThing regulation of transforming growth factor beta activation Any process that modulates the frequency, rate or extent of transforming growth factor beta activation. tmpzr1t_l9r_go_relaxed.owl regulation of TGF-B activation|regulation of TGF-beta activation|regulation of TGFB activation|regulation of TGFbeta activation|regulation of L-TGF-beta activation|regulation of latent TGF-beta activation bf 2012-10-01T10:32:00Z biological_process owl:Class GO:1902166 biolink:NamedThing negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. tmpzr1t_l9r_go_relaxed.owl down regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|inhibition of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|downregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|inhibition of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|downregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|down regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator lb 2013-05-22T12:45:15Z biological_process owl:Class GO:1902165 biolink:NamedThing regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. tmpzr1t_l9r_go_relaxed.owl regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis lb 2013-05-22T12:45:10Z biological_process owl:Class GO:1904639 biolink:NamedThing cellular response to resveratrol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus. tmpzr1t_l9r_go_relaxed.owl sl 2015-08-31T17:07:44Z biological_process owl:Class GO:2000588 biolink:NamedThing positive regulation of platelet-derived growth factor receptor-beta signaling pathway Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. tmpzr1t_l9r_go_relaxed.owl positive regulation of platelet-derived growth factor receptor-beta signalling pathway|positive regulation of PDGFR-beta signaling pathway|positive regulation of PDGF receptor-beta signaling pathway|positive regulation of betaPDGF receptor signaling pathway bf 2011-04-07T03:27:58Z biological_process owl:Class GO:0007053 biolink:NamedThing spindle assembly involved in male meiosis The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0019482 biolink:NamedThing beta-alanine metabolic process The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. tmpzr1t_l9r_go_relaxed.owl beta-alanine metabolism Wikipedia:Beta-alanine biological_process owl:Class GO:0006520 biolink:NamedThing cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl amino acid and derivative metabolism|amino acid metabolic process|cellular amino acid metabolism|cellular amino acid and derivative metabolic process GO:0006519 biological_process owl:Class GO:1903818 biolink:NamedThing positive regulation of voltage-gated potassium channel activity Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity. tmpzr1t_l9r_go_relaxed.owl upregulation of voltage gated potassium channel activity|positive regulation of voltage-sensitive potassium channel|activation of voltage-sensitive potassium channel|activation of voltage-dependent potassium channel activity|up-regulation of voltage-gated potassium channel activity|activation of voltage-gated potassium channel activity|activation of voltage gated potassium channel activity|up-regulation of voltage gated potassium channel activity|upregulation of voltage-gated potassium channel activity|up regulation of voltage-sensitive potassium channel|activation of voltage-gated potassium ion channel activity|up regulation of voltage-dependent potassium channel activity|up-regulation of voltage-gated potassium ion channel activity|positive regulation of voltage-gated potassium ion channel activity|upregulation of voltage-gated potassium ion channel activity|upregulation of voltage-dependent potassium channel activity|up-regulation of voltage-dependent potassium channel activity|up regulation of voltage-gated potassium ion channel activity|up regulation of voltage gated potassium channel activity|upregulation of voltage-sensitive potassium channel|positive regulation of voltage-dependent potassium channel activity|positive regulation of voltage gated potassium channel activity|up-regulation of voltage-sensitive potassium channel|up regulation of voltage-gated potassium channel activity sl 2015-01-16T17:22:18Z biological_process owl:Class GO:1990665 biolink:NamedThing AnxA2-p11 complex A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10). tmpzr1t_l9r_go_relaxed.owl AnxA2:S100A10 heterotetramer|(A2.p11)2 complex|AnxA2.p11 complex|Annexin A2-p11 complex|Annexin A2 tetramer|(p11)2.(AnxA2)2 complex bf 2015-03-02T10:07:42Z cellular_component owl:Class GO:0006304 biolink:NamedThing DNA modification The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0043412 biolink:NamedThing macromolecule modification The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0033673 biolink:NamedThing negative regulation of kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. tmpzr1t_l9r_go_relaxed.owl inhibition of kinase activity|kinase inhibitor|down-regulation of kinase activity|downregulation of kinase activity|down regulation of kinase activity biological_process owl:Class GO:1904637 biolink:NamedThing cellular response to ionomycin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus. tmpzr1t_l9r_go_relaxed.owl sl 2015-08-31T14:39:25Z biological_process owl:Class GO:0071398 biolink:NamedThing cellular response to fatty acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2009-12-11T04:39:56Z biological_process owl:Class GO:0060001 biolink:NamedThing minus-end directed microfilament motor activity A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers. tmpzr1t_l9r_go_relaxed.owl minus-end directed actin filament motor activity|minus-end directed actin-filament motor activity|pointed-end directed actin-filament motor activity molecular_function owl:Class GO:0000146 biolink:NamedThing microfilament motor activity A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. tmpzr1t_l9r_go_relaxed.owl actin-activated ATPase activity|muscle motor activity|actin-dependent ATPase activity|myosin ATPase activity|actin filament motor activity|actin-filament motor activity https://github.com/geneontology/go-ontology/issues/20877 Reactome:R-HSA-432237|Reactome:R-HSA-9023171|Reactome:R-HSA-2316352|EC:5.6.1.8 GO:0030898 molecular_function owl:Class GO:0042650 biolink:NamedThing prothylakoid membrane The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0055035 biolink:NamedThing plastid thylakoid membrane The lipid bilayer membrane of any thylakoid within a plastid. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:1900425 biolink:NamedThing negative regulation of defense response to bacterium Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. tmpzr1t_l9r_go_relaxed.owl inhibition of response to pathogenic bacteria (incompatible interaction)|negative regulation of antibacterial peptide activity|negative regulation of defence response to bacterium|inhibition of defence response to pathogenic bacterium, incompatible interaction|down regulation of defence response to bacterium|inhibition of defense response to bacteria|inhibition of resistance response to pathogenic bacteria|downregulation of defence response to bacterium|down-regulation of antibacterial peptide activity|inhibition of defense response to bacterium|negative regulation of defense response to bacteria|down-regulation of defense response to bacterium|down-regulation of defence response to bacteria|downregulation of defense response to bacteria|down-regulation of defence response to bacterium|inhibition of defence response to bacterium|inhibition of defence response to bacteria|downregulation of antibacterial peptide activity|down regulation of defense response to bacteria|inhibition of defence response to pathogenic bacteria, incompatible interaction|inhibition of response to pathogenic bacterium (incompatible interaction)|negative regulation of defense response to bacterium, incompatible interaction|inhibition of defense response to bacterium, incompatible interaction|inhibition of antibacterial peptide activity|downregulation of defence response to bacteria|downregulation of defense response to bacterium|negative regulation of defence response to bacteria|down regulation of antibacterial peptide activity|down-regulation of defense response to bacteria|down regulation of defence response to bacteria|inhibition of resistance response to pathogenic bacterium|down regulation of defense response to bacterium dhl 2012-04-24T10:12:54Z GO:1902478 biological_process owl:Class GO:1900424 biolink:NamedThing regulation of defense response to bacterium Any process that modulates the frequency, rate or extent of defense response to bacterium. tmpzr1t_l9r_go_relaxed.owl regulation of resistance response to pathogenic bacteria|regulation of defence response to bacteria|regulation of resistance response to pathogenic bacterium|regulation of defense response to bacterium, incompatible interaction|regulation of defence response to pathogenic bacterium, incompatible interaction|regulation of antibacterial peptide activity|regulation of defence response to bacterium, incompatible interaction|regulation of defence response to bacterium|regulation of defense response to bacteria|regulation of defence response to pathogenic bacteria, incompatible interaction dhl 2012-04-24T10:12:43Z GO:1902477 biological_process owl:Class GO:0036075 biolink:NamedThing replacement ossification Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. tmpzr1t_l9r_go_relaxed.owl indirect ossification bf 2011-12-19T01:53:16Z biological_process owl:Class GO:0001503 biolink:NamedThing ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. tmpzr1t_l9r_go_relaxed.owl bone formation|osteogenesis|bone biosynthesis Wikipedia:Ossification Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. biological_process owl:Class GO:1904296 biolink:NamedThing negative regulation of osmolarity-sensing cation channel activity Any process that stops, prevents or reduces the frequency, rate or extent of osmolarity-sensing cation channel activity. tmpzr1t_l9r_go_relaxed.owl down-regulation of osmolarity-sensing cation channel activity|down regulation of osmolarity-sensing cation channel activity|downregulation of osmolarity-sensing cation channel activity|inhibition of osmolarity-sensing cation channel activity sl 2015-06-09T17:35:46Z biological_process owl:Class GO:0052733 biolink:NamedThing quinate 3-dehydrogenase (NADP+) activity Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+. tmpzr1t_l9r_go_relaxed.owl quinate:NADP 3-oxidoreductase activity|quinic dehydrogenase activity|quinate:NADP(+) 3-oxidoreductase activity KEGG_REACTION:R06846|EC:1.1.1.282|RHEA:18425 ai 2011-08-16T04:23:47Z molecular_function owl:Class GO:0042167 biolink:NamedThing heme catabolic process The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. tmpzr1t_l9r_go_relaxed.owl haem catabolic process|heme degradation|haem catabolism|heme breakdown|heme catabolism biological_process owl:Class GO:0006787 biolink:NamedThing porphyrin-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. tmpzr1t_l9r_go_relaxed.owl porphyrin breakdown|porphyrin catabolic process|porphyrin catabolism|porphyrin degradation biological_process owl:Class GO:0019402 biolink:NamedThing galactitol metabolic process The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. tmpzr1t_l9r_go_relaxed.owl galactitol metabolism biological_process owl:Class GO:0006059 biolink:NamedThing hexitol metabolic process The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule. tmpzr1t_l9r_go_relaxed.owl hexitol metabolism|sugar alcohol (hexitol) metabolism|sugar alcohol (hexitol) metabolic process biological_process owl:Class GO:0033006 biolink:NamedThing regulation of mast cell activation involved in immune response Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. tmpzr1t_l9r_go_relaxed.owl regulation of mast cell activation during immune response biological_process owl:Class GO:1902888 biolink:NamedThing protein localization to astral microtubule A process in which a protein is transported to, or maintained in, a location within an astral microtubule. tmpzr1t_l9r_go_relaxed.owl protein localization in astral microtubule|protein localisation to astral microtubule|protein localisation in astral microtubule kmv 2014-04-05T21:26:34Z biological_process owl:Class GO:1902889 biolink:NamedThing protein localization to spindle microtubule A process in which a protein is transported to, or maintained in, a location within a spindle microtubule. tmpzr1t_l9r_go_relaxed.owl protein localization in spindle microtubule|protein localisation in spindle microtubule|protein localisation to spindle microtubule kmv 2014-04-05T21:31:39Z biological_process owl:Class GO:0097293 biolink:NamedThing XMP biosynthetic process The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate. tmpzr1t_l9r_go_relaxed.owl XMP formation|XMP biosynthesis|XMP anabolism|XMP synthesis pr 2012-04-26T09:54:13Z biological_process owl:Class GO:0097292 biolink:NamedThing XMP metabolic process The chemical reactions and pathways involving XMP, xanthosine monophosphate. tmpzr1t_l9r_go_relaxed.owl XMP metabolism pr 2012-04-26T09:51:16Z biological_process owl:Class GO:0035129 biolink:NamedThing post-embryonic hindlimb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0035127 biolink:NamedThing post-embryonic limb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0102326 biolink:NamedThing 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O <=> 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-13171 molecular_function owl:Class GO:0016823 biolink:NamedThing hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. tmpzr1t_l9r_go_relaxed.owl EC:3.7.1.- molecular_function owl:Class GO:0055131 biolink:NamedThing C3HC4-type RING finger domain binding Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway. tmpzr1t_l9r_go_relaxed.owl jid 2009-10-22T02:20:33Z molecular_function owl:Class GO:2001310 biolink:NamedThing gliotoxin biosynthetic process The chemical reactions and pathways resulting in the formation of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. tmpzr1t_l9r_go_relaxed.owl gliotoxin formation|gliotoxin anabolism|gliotoxin synthesis|gliotoxin biosynthesis pr 2012-03-15T03:42:18Z biological_process owl:Class GO:1902897 biolink:NamedThing regulation of postsynaptic density protein 95 clustering Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering. tmpzr1t_l9r_go_relaxed.owl regulation of PSD-95 clustering|regulation of post-synaptic density protein 95 clustering|regulation of Dlg4 clustering als 2014-04-09T14:52:08Z biological_process owl:Class GO:1905874 biolink:NamedThing regulation of postsynaptic density organization Any process that modulates the frequency, rate or extent of postsynaptic density organization. tmpzr1t_l9r_go_relaxed.owl regulation of post-synaptic density organization|regulation of post synaptic density organization|regulation of PSD organization|regulation of postsynaptic density organisation sl 2017-01-27T19:53:32Z biological_process owl:Class GO:1900979 biolink:NamedThing positive regulation of tatiopterin metabolic process Any process that activates or increases the frequency, rate or extent of tatiopterin metabolic process. tmpzr1t_l9r_go_relaxed.owl positive regulation of tatiopterin metabolism|up-regulation of tatiopterin metabolism|upregulation of tatiopterin metabolism|up-regulation of tatiopterin metabolic process|up regulation of tatiopterin metabolism|upregulation of tatiopterin metabolic process|activation of tatiopterin metabolic process|activation of tatiopterin metabolism|up regulation of tatiopterin metabolic process tt 2012-06-14T04:03:37Z biological_process owl:Class GO:0062013 biolink:NamedThing positive regulation of small molecule metabolic process Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. tmpzr1t_l9r_go_relaxed.owl positive regulation of small molecule metabolism dph 2018-03-19T14:25:10Z biological_process owl:Class GO:0090321 biolink:NamedThing positive regulation of chylomicron remnant clearance Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded. tmpzr1t_l9r_go_relaxed.owl tb 2010-04-30T10:20:26Z biological_process owl:Class GO:0008808 biolink:NamedThing cardiolipin synthase activity Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. tmpzr1t_l9r_go_relaxed.owl diphosphatidylglycerol synthase activity|cardiolipin synthetase 2 activity|cardiolipin synthase 2 activity|cardiolipin synthetase activity RHEA:31451|MetaCyc:CARDIOLIPSYN-RXN GO:0043788 molecular_function owl:Class GO:0030572 biolink:NamedThing phosphatidyltransferase activity Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0001117 biolink:NamedThing protein-DNA-RNA complex disassembly The disaggregation of a protein-DNA-RNA complex into its constituent components. tmpzr1t_l9r_go_relaxed.owl krc 2010-12-03T04:04:07Z biological_process owl:Class GO:0001115 biolink:NamedThing protein-DNA-RNA complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex. tmpzr1t_l9r_go_relaxed.owl protein-DNA-RNA complex subunit organisation krc 2010-12-03T04:00:02Z biological_process owl:Class GO:0002735 biolink:NamedThing positive regulation of myeloid dendritic cell cytokine production Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production. tmpzr1t_l9r_go_relaxed.owl up regulation of myeloid dendritic cell cytokine production|stimulation of myeloid dendritic cell cytokine production|activation of myeloid dendritic cell cytokine production|upregulation of myeloid dendritic cell cytokine production|up-regulation of myeloid dendritic cell cytokine production biological_process owl:Class GO:0009163 biolink:NamedThing nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). tmpzr1t_l9r_go_relaxed.owl nucleoside formation|nucleoside anabolism|nucleoside synthesis|nucleoside biosynthesis biological_process owl:Class GO:0034404 biolink:NamedThing nucleobase-containing small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. tmpzr1t_l9r_go_relaxed.owl nucleobase, nucleoside and nucleotide formation|nucleobase, nucleoside and nucleotide anabolism|nucleobase, nucleoside and nucleotide biosynthesis|nucleobase, nucleoside and nucleotide synthesis biological_process owl:Class GO:0010936 biolink:NamedThing negative regulation of macrophage cytokine production Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0002719 biolink:NamedThing negative regulation of cytokine production involved in immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. tmpzr1t_l9r_go_relaxed.owl negative regulation of cytokine biosynthetic process involved in immune response|negative regulation of cytokine secretion involved in immune response|downregulation of cytokine production during immune response|down regulation of cytokine production during immune response|down-regulation of cytokine production during immune response|inhibition of cytokine production during immune response|negative regulation of cytokine production during immune response GO:0002740|GO:0002743 biological_process owl:Class GO:2000628 biolink:NamedThing regulation of miRNA metabolic process Any process that modulates the frequency, rate or extent of miRNA metabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of microRNA metabolic process dph 2011-04-18T03:47:54Z biological_process owl:Class GO:0051252 biolink:NamedThing regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. tmpzr1t_l9r_go_relaxed.owl regulation of RNA metabolism biological_process owl:Class GO:1990432 biolink:NamedThing siRNA 3'-end processing The process of forming the mature 3' end of a siRNA molecule. tmpzr1t_l9r_go_relaxed.owl small interfering RNA 3'-end processing|siRNA 3' end processing jl 2014-07-29T15:38:38Z biological_process owl:Class GO:0043628 biolink:NamedThing ncRNA 3'-end processing Any process involved in forming the mature 3' end of a non-coding RNA molecule. tmpzr1t_l9r_go_relaxed.owl ncRNA 3' end processing biological_process owl:Class GO:0047738 biolink:NamedThing cellobiose phosphorylase activity Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose. tmpzr1t_l9r_go_relaxed.owl cellobiose:phosphate alpha-D-glucosyltransferase activity EC:2.4.1.20|MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN|RHEA:19493 molecular_function owl:Class GO:0004645 biolink:NamedThing 1,4-alpha-oligoglucan phosphorylase activity Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. tmpzr1t_l9r_go_relaxed.owl polyphosphorylase activity|potato phosphorylase|amylopectin phosphorylase|1,4-alpha-glucan phosphorylase activity|1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity|alpha-glucan phosphorylase|glucosan phosphorylase|muscle phosphorylase a and b activity|amylophosphorylase activity|muscle phosphorylase|granulose phosphorylase|starch phosphorylase|myophosphorylase|glucan phosphorylase MetaCyc:RXN-1826|EC:2.4.1.1 molecular_function owl:Class GO:1905637 biolink:NamedThing regulation of mitochondrial mRNA catabolic process Any process that modulates the frequency, rate or extent of mitochondrial mRNA catabolic process. tmpzr1t_l9r_go_relaxed.owl tb 2016-11-03T20:23:57Z biological_process owl:Class GO:0140326 biolink:NamedThing ATPase-coupled intramembrane lipid transporter activity Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases. tmpzr1t_l9r_go_relaxed.owl aminophospholipid-transporting ATPase|phospholipid flippase activity|phospholipid-transporting ATPase activity|phospholipid translocating ATPase activity|phospholipid-translocating ATPase activity|ATPase-coupled phospholipid transporter activity|ATPase-dependent phospholipid transporter activity https://github.com/geneontology/go-ontology/issues/17648|https://github.com/geneontology/go-ontology/issues/21612 EC:7.6.2.1|Reactome:R-HSA-939763|MetaCyc:3.6.3.1-RXN|Reactome:R-HSA-947591 pg 2019-04-29T12:42:26Z GO:0004012|GO:0008557 molecular_function owl:Class GO:0140303 biolink:NamedThing intramembrane lipid transporter activity Enables the transport of a lipid from a region of a membrane to a different region on the same membrane. tmpzr1t_l9r_go_relaxed.owl flippase activity|translocase activity https://github.com/geneontology/go-ontology/issues/17648|https://github.com/geneontology/go-ontology/issues/19477 pg 2019-03-01T20:14:09Z molecular_function owl:Class GO:0050072 biolink:NamedThing m7G(5')pppN diphosphatase activity Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. tmpzr1t_l9r_go_relaxed.owl 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|decapase activity|M(7)G(5')pppN pyrophosphatase activity|m7G(5')pppN pyrophosphatase activity EC:3.6.1.30|MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN molecular_function owl:Class GO:0016462 biolink:NamedThing pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-6810472 molecular_function owl:Class GO:0018516 biolink:NamedThing 2,4-dichlorobenzoyl-CoA reductase activity Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH. tmpzr1t_l9r_go_relaxed.owl 4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating) RHEA:23076|EC:1.21.1.2|MetaCyc:1.3.1.63-RXN|UM-BBD_reactionID:r0138|KEGG_REACTION:R05276 molecular_function owl:Class GO:0016628 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-9661726|EC:1.3.1.-|Reactome:R-HSA-9661745|Reactome:R-HSA-4419979|Reactome:R-HSA-4755572 molecular_function owl:Class GO:0051969 biolink:NamedThing regulation of transmission of nerve impulse Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. tmpzr1t_l9r_go_relaxed.owl regulation of conduction of nerve impulse biological_process owl:Class GO:0023051 biolink:NamedThing regulation of signaling Any process that modulates the frequency, rate or extent of a signaling process. tmpzr1t_l9r_go_relaxed.owl regulation of signaling process|regulation of signalling process 2010-02-16T09:30:50Z biological_process owl:Class GO:0032818 biolink:NamedThing negative regulation of natural killer cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation. tmpzr1t_l9r_go_relaxed.owl down-regulation of natural killer cell proliferation|negative regulation of NK cell proliferation|downregulation of natural killer cell proliferation|down regulation of natural killer cell proliferation|inhibition of natural killer cell proliferation biological_process owl:Class GO:1901891 biolink:NamedThing regulation of cell septum assembly Any process that modulates the frequency, rate or extent of cell septum assembly. tmpzr1t_l9r_go_relaxed.owl tb 2013-02-06T20:14:40Z biological_process owl:Class GO:0032954 biolink:NamedThing regulation of cytokinetic process Any process that modulates the frequency, rate or extent of a cytokinetic process. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0048656 biolink:NamedThing anther wall tapetum formation The process that gives rise to the anther wall tapetum. This process pertains to the initial formation of a structure from unspecified parts. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. tmpzr1t_l9r_go_relaxed.owl tapetum formation|tapetal layer formation biological_process owl:Class GO:0048646 biolink:NamedThing anatomical structure formation involved in morphogenesis The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. tmpzr1t_l9r_go_relaxed.owl formation of an anatomical structure involved in morphogenesis Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. biological_process owl:Class GO:0046155 biolink:NamedThing rhodopsin catabolic process The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. tmpzr1t_l9r_go_relaxed.owl rhodopsin degradation|rhodopsin breakdown|rhodopsin catabolism biological_process owl:Class GO:0046154 biolink:NamedThing rhodopsin metabolic process The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. tmpzr1t_l9r_go_relaxed.owl rhodopsin metabolism biological_process owl:Class GO:0047253 biolink:NamedThing alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP. tmpzr1t_l9r_go_relaxed.owl N-acetylglucosaminyltransferase VI activity|UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity|mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity|alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity|mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity|uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI|uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity MetaCyc:2.4.1.201-RXN|RHEA:19945|EC:2.4.1.201 molecular_function owl:Class GO:0140103 biolink:NamedThing catalytic activity, acting on a glycoprotein Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-15T19:27:54Z molecular_function owl:Class GO:1900246 biolink:NamedThing positive regulation of RIG-I signaling pathway Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway. tmpzr1t_l9r_go_relaxed.owl up regulation of RIG-I signaling pathway|up regulation of DDX58 signaling pathway|positive regulation of DDX58 signaling pathway|positive regulation of RIG-I signalling pathway|activation of DDX58 signaling pathway|activation of RIG-I signaling pathway|activation of retinoic acid inducible gene I signaling pathway|up-regulation of RIG-I signaling pathway|up regulation of retinoic acid inducible gene I signaling pathway|up-regulation of retinoic acid inducible gene I signaling pathway|upregulation of retinoic acid inducible gene I signaling pathway|positive regulation of retinoic acid inducible gene I signaling pathway|upregulation of DDX58 signaling pathway|upregulation of RIG-I signaling pathway|up-regulation of DDX58 signaling pathway ss 2012-04-02T11:00:28Z biological_process owl:Class GO:0002833 biolink:NamedThing positive regulation of response to biotic stimulus Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. tmpzr1t_l9r_go_relaxed.owl upregulation of response to biotic stimulus|up-regulation of response to biotic stimulus|stimulation of response to biotic stimulus|up regulation of response to biotic stimulus|activation of response to biotic stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0021761 biolink:NamedThing limbic system development The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0048731 biolink:NamedThing system development The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0046681 biolink:NamedThing response to carbamate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase. tmpzr1t_l9r_go_relaxed.owl carbamate resistance|carbamate susceptibility/resistance biological_process owl:Class GO:0017085 biolink:NamedThing response to insecticide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. tmpzr1t_l9r_go_relaxed.owl insecticide resistance|insecticide susceptibility/resistance biological_process owl:Class GO:1901520 biolink:NamedThing aspyridone B catabolic process The chemical reactions and pathways resulting in the breakdown of aspyridone B. tmpzr1t_l9r_go_relaxed.owl aspyridone B degradation|aspyridone B catabolism|aspyridone B breakdown di 2012-10-18T18:31:44Z biological_process owl:Class GO:0030640 biolink:NamedThing polyketide catabolic process The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. tmpzr1t_l9r_go_relaxed.owl polyketide breakdown|polyketide degradation|polyketide catabolism biological_process owl:Class GO:1901023 biolink:NamedThing 4-hydroxyphenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of 4-hydroxyphenylacetate. tmpzr1t_l9r_go_relaxed.owl 4-hydroxyphenylacetate breakdown|4-hydroxyphenylacetate catabolism|4-hydroxyphenylacetate degradation yaf 2012-06-18T02:31:58Z biological_process owl:Class GO:0070922 biolink:NamedThing small RNA loading onto RISC The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA. tmpzr1t_l9r_go_relaxed.owl RISC assembly|gene silencing by RNA, small RNA loading onto RISC mah 2009-09-11T03:57:38Z biological_process owl:Class GO:0019969 biolink:NamedThing interleukin-10 binding Binding to interleukin-10. tmpzr1t_l9r_go_relaxed.owl IL-10 binding molecular_function owl:Class GO:0019838 biolink:NamedThing growth factor binding Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. tmpzr1t_l9r_go_relaxed.owl neurotrophin TRK receptor activity molecular_function owl:Class GO:0018870 biolink:NamedThing anaerobic 2-aminobenzoate metabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen. tmpzr1t_l9r_go_relaxed.owl anaerobic 2-aminobenzoate metabolism UM-BBD_pathwayID:abz biological_process owl:Class GO:0043420 biolink:NamedThing anthranilate metabolic process The chemical reactions and pathways involving anthranilate (2-aminobenzoate). tmpzr1t_l9r_go_relaxed.owl ortho-aminobenzoic acid metabolic process|2-aminobenzoate metabolic process|ortho-aminobenzoic acid metabolism|anthranilic acid metabolic process|anthranilic acid metabolism|2-aminobenzoate metabolism|anthranilate metabolism UM-BBD_pathwayID:abz2 GO:0018869 biological_process owl:Class GO:0045938 biolink:NamedThing positive regulation of circadian sleep/wake cycle, sleep Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. tmpzr1t_l9r_go_relaxed.owl up-regulation of circadian sleep/wake cycle, sleep|activation of circadian sleep/wake cycle, sleep|up regulation of circadian sleep/wake cycle, sleep|upregulation of circadian sleep/wake cycle, sleep|positive regulation of sleep|stimulation of circadian sleep/wake cycle, sleep biological_process owl:Class GO:0045187 biolink:NamedThing regulation of circadian sleep/wake cycle, sleep Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. tmpzr1t_l9r_go_relaxed.owl regulation of sleep biological_process owl:Class GO:1901054 biolink:NamedThing sarcosine biosynthetic process The chemical reactions and pathways resulting in the formation of sarcosine. tmpzr1t_l9r_go_relaxed.owl sarcosine biosynthesis|sarcosine formation|sarcosine anabolism|sarcosine synthesis yaf 2012-06-28T04:52:37Z biological_process owl:Class GO:0042398 biolink:NamedThing cellular modified amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. tmpzr1t_l9r_go_relaxed.owl cellular amino acid derivative anabolism|cellular modified amino acid synthesis|cellular modified amino acid biosynthesis|cellular amino acid derivative synthesis|cellular amino acid derivative biosynthesis|amino acid derivative biosynthetic process|cellular amino acid derivative biosynthetic process|cellular amino acid derivative formation|cellular modified amino acid anabolism|cellular modified amino acid formation biological_process owl:Class GO:0099015 biolink:NamedThing degradation of host chromosome by virus The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis. tmpzr1t_l9r_go_relaxed.owl VZ:3947 biological_process owl:Class GO:0039637 biolink:NamedThing catabolism by virus of host DNA The breakdown of host DNA, deoxyribonucleic acid, by a virus. tmpzr1t_l9r_go_relaxed.owl bf 2012-08-10T15:59:22Z biological_process owl:Class GO:0045978 biolink:NamedThing negative regulation of nucleoside metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. tmpzr1t_l9r_go_relaxed.owl down regulation of nucleoside metabolic process|downregulation of nucleoside metabolic process|negative regulation of nucleoside metabolism|inhibition of nucleoside metabolic process|down-regulation of nucleoside metabolic process biological_process owl:Class GO:0045934 biolink:NamedThing negative regulation of nucleobase-containing compound metabolic process Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. tmpzr1t_l9r_go_relaxed.owl down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism|downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process biological_process owl:Class GO:1904840 biolink:NamedThing positive regulation of male germ-line stem cell asymmetric division Any process that activates or increases the frequency, rate or extent of male germ-line stem cell asymmetric division. tmpzr1t_l9r_go_relaxed.owl positive regulation of male germ-line stem cell renewal|up regulation of male germ-line stem cell asymmetric division|activation of male germ-line stem cell asymmetric division|activation of male germ-line stem cell renewal|up-regulation of male germ-line stem cell asymmetric division|up regulation of male germ-line stem cell renewal|up-regulation of male germ-line stem cell renewal|upregulation of male germ-line stem cell asymmetric division|upregulation of male germ-line stem cell renewal sl 2015-12-05T00:28:46Z biological_process owl:Class GO:2000243 biolink:NamedThing positive regulation of reproductive process Any process that activates or increases the frequency, rate or extent of reproductive process. tmpzr1t_l9r_go_relaxed.owl mah 2010-11-10T02:44:08Z biological_process owl:Class GO:0019622 biolink:NamedThing 3-(3-hydroxy)phenylpropionate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. tmpzr1t_l9r_go_relaxed.owl 3-(3-hydroxy)phenylpropionate degradation|3-(3-hydroxy)phenylpropionate catabolism|3-(3-hydroxy)phenylpropionate breakdown MetaCyc:HCAMHPDEG-PWY biological_process owl:Class GO:0046435 biolink:NamedThing 3-(3-hydroxy)phenylpropionate metabolic process The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. tmpzr1t_l9r_go_relaxed.owl 3-(3-hydroxy)phenylpropionate metabolism biological_process owl:Class GO:0046752 biolink:NamedThing viral capsid precursor transport to host cell nucleus Any process in which viral capsid precursors are transported to a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid. tmpzr1t_l9r_go_relaxed.owl viral capsid precursor localization in host cell nucleus|localization of viral capsid precursors in nucleus|establishment and maintenance of viral capsid precursor localization in nucleus|viral capsid precursor localisation in host cell nucleus|viral capsid precursor localization to host cell nucleus|nuclear localization of viral capsid precursors biological_process owl:Class GO:0030581 biolink:NamedThing symbiont intracellular protein transport in host The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl intracellular protein transport in host|intracellular protein transport in other organism involved in symbiotic interaction|intracellular protein transport in other organism during symbiotic interaction|host cell protein transport GO:0051708 biological_process owl:Class GO:0061223 biolink:NamedThing mesonephric mesenchymal cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state. tmpzr1t_l9r_go_relaxed.owl dph 2010-08-19T01:21:48Z biological_process owl:Class GO:0061208 biolink:NamedThing cell differentiation involved in mesonephros development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state. tmpzr1t_l9r_go_relaxed.owl dph 2010-08-17T03:21:23Z biological_process owl:Class GO:0009131 biolink:NamedThing pyrimidine nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. tmpzr1t_l9r_go_relaxed.owl pyrimidine nucleoside monophosphate breakdown|pyrimidine nucleoside monophosphate catabolism|pyrimidine nucleoside monophosphate degradation biological_process owl:Class GO:0009125 biolink:NamedThing nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. tmpzr1t_l9r_go_relaxed.owl nucleoside monophosphate breakdown|nucleoside monophosphate catabolism|nucleoside monophosphate degradation biological_process owl:Class GO:0021965 biolink:NamedThing spinal cord ventral commissure morphogenesis The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0021952 biolink:NamedThing central nervous system projection neuron axonogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. tmpzr1t_l9r_go_relaxed.owl central nervous system axon tract development biological_process owl:Class GO:0033209 biolink:NamedThing tumor necrosis factor-mediated signaling pathway A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. tmpzr1t_l9r_go_relaxed.owl adipocytokine signaling pathway|TNF-alpha-mediated signaling pathway|tumor necrosis factor-mediated signalling pathway|tumor necrosis factor alpha-mediated signaling pathway biological_process owl:Class GO:0019221 biolink:NamedThing cytokine-mediated signaling pathway A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. tmpzr1t_l9r_go_relaxed.owl cytokine and chemokine mediated signaling pathway|cytokine mediated signalling pathway biological_process owl:Class GO:1990858 biolink:NamedThing cellular response to lectin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. tmpzr1t_l9r_go_relaxed.owl This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity. sl 2015-09-24T15:34:42Z biological_process owl:Class GO:1990840 biolink:NamedThing response to lectin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. tmpzr1t_l9r_go_relaxed.owl This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity. sl 2015-08-27T20:02:21Z biological_process owl:Class GO:1990072 biolink:NamedThing TRAPPIII protein complex A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins. tmpzr1t_l9r_go_relaxed.owl bhm 2013-03-28T14:28:59Z cellular_component owl:Class GO:0030008 biolink:NamedThing TRAPP complex A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active. tmpzr1t_l9r_go_relaxed.owl transport protein particle|TRAPP1|transport protein particle complex|TRAPP2 Wikipedia:TRAPP_complex cellular_component owl:Class GO:1990362 biolink:NamedThing butanol dehydrogenase activity Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+. tmpzr1t_l9r_go_relaxed.owl RHEA:33199 tt 2014-04-23T21:14:09Z molecular_function owl:Class GO:0004022 biolink:NamedThing alcohol dehydrogenase (NAD+) activity Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. tmpzr1t_l9r_go_relaxed.owl aldo-keto reductase (NAD) activity|primary alcohol dehydrogenase|alcohol dehydrogenase activity|NADH-alcohol dehydrogenase|NAD-specific aromatic alcohol dehydrogenase|NADH-aldehyde dehydrogenase|yeast alcohol dehydrogenase|alcohol:NAD+ oxidoreductase|aldehyde dehydrogenase (NAD) activity|NAD-dependent alcohol dehydrogenase|aliphatic alcohol dehydrogenase|ethanol dehydrogenase|ADH UM-BBD_enzymeID:e0023|RHEA:10740|Reactome:R-HSA-2162078|MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN|EC:1.1.1.1 molecular_function owl:Class GO:0002584 biolink:NamedThing negative regulation of antigen processing and presentation of peptide antigen Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen. tmpzr1t_l9r_go_relaxed.owl down regulation of antigen processing and presentation of peptide antigen|down-regulation of antigen processing and presentation of peptide antigen|negative regulation of peptide antigen processing and presentation|inhibition of antigen processing and presentation of peptide antigen|downregulation of antigen processing and presentation of peptide antigen biological_process owl:Class GO:0007041 biolink:NamedThing lysosomal transport The directed movement of substances into, out of or within a lysosome. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0007034 biolink:NamedThing vacuolar transport The directed movement of substances into, out of or within a vacuole. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1901641 biolink:NamedThing ITP binding Binding to ITP. tmpzr1t_l9r_go_relaxed.owl tb 2012-11-15T22:56:39Z molecular_function owl:Class GO:0032555 biolink:NamedThing purine ribonucleotide binding Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0010899 biolink:NamedThing regulation of phosphatidylcholine catabolic process Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0150172 biolink:NamedThing regulation of phosphatidylcholine metabolic process Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process. tmpzr1t_l9r_go_relaxed.owl bc 2020-01-21T14:03:11Z biological_process owl:Class GO:0032395 biolink:NamedThing MHC class II receptor activity Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. tmpzr1t_l9r_go_relaxed.owl T cell receptor activity|alpha-beta T cell receptor activity|gamma-delta T cell receptor activity Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves. molecular_function owl:Class GO:0150065 biolink:NamedThing regulation of deacetylase activity Any process that modulates the frequency, rate or extent of deacetylase activity. tmpzr1t_l9r_go_relaxed.owl bc 2018-07-23T12:24:28Z biological_process owl:Class GO:0051336 biolink:NamedThing regulation of hydrolase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. tmpzr1t_l9r_go_relaxed.owl hydrolase regulator biological_process owl:Class GO:1903967 biolink:NamedThing response to micafungin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus. tmpzr1t_l9r_go_relaxed.owl al 2015-02-27T09:57:38Z biological_process owl:Class GO:1901652 biolink:NamedThing response to peptide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. tmpzr1t_l9r_go_relaxed.owl pr 2012-11-20T09:45:15Z biological_process owl:Class GO:2000802 biolink:NamedThing positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation. tmpzr1t_l9r_go_relaxed.owl positive regulation of endocardial cushion to mesenchymal transition involved in valve formation bf 2011-07-01T12:31:25Z biological_process owl:Class GO:0140051 biolink:NamedThing positive regulation of endocardial cushion to mesenchymal transition Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition. tmpzr1t_l9r_go_relaxed.owl pg 2017-06-26T09:11:03Z biological_process owl:Class GO:0071323 biolink:NamedThing cellular response to chitin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2009-12-10T05:25:54Z biological_process owl:Class GO:0071417 biolink:NamedThing cellular response to organonitrogen compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. tmpzr1t_l9r_go_relaxed.owl cellular response to organic nitrogen mah 2009-12-14T04:07:27Z biological_process owl:Class GO:0052696 biolink:NamedThing flavonoid glucuronidation The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor. tmpzr1t_l9r_go_relaxed.owl flavonoid glucuronide biosynthetic process|flavonoid glucuronoside biosynthetic process|flavonoid glucuronide biosynthesis|flavonoid glucuronoside biosynthesis ai 2011-07-27T05:37:44Z biological_process owl:Class GO:0009812 biolink:NamedThing flavonoid metabolic process The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. tmpzr1t_l9r_go_relaxed.owl flavonoid metabolism biological_process owl:Class GO:1905938 biolink:NamedThing positive regulation of germ cell proliferation Any process that activates or increases the frequency, rate or extent of germ cell proliferation. tmpzr1t_l9r_go_relaxed.owl activation of germ cell proliferation|up regulation of germ cell proliferation|up-regulation of germ cell proliferation|upregulation of germ cell proliferation hbye 2017-02-09T14:51:51Z biological_process owl:Class GO:1905936 biolink:NamedThing regulation of germ cell proliferation Any process that modulates the frequency, rate or extent of germ cell proliferation. tmpzr1t_l9r_go_relaxed.owl hbye 2017-02-09T14:51:31Z biological_process owl:Class GO:0050586 biolink:NamedThing 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H(+) + O(2) = N-acetylanthranilate + CO. tmpzr1t_l9r_go_relaxed.owl 1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity|3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)|3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity|(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity|1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity EC:1.13.11.48|RHEA:21572|MetaCyc:1.13.11.48-RXN|KEGG_REACTION:R05720 molecular_function owl:Class GO:0016702 biolink:NamedThing oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-2161917|Reactome:R-HSA-9018880|Reactome:R-HSA-5164399|Reactome:R-HSA-9026408|Reactome:R-HSA-2161907|Reactome:R-HSA-9020274|Reactome:R-HSA-9026918|EC:1.13.11.-|Reactome:R-HSA-2161775 molecular_function owl:Class GO:0070094 biolink:NamedThing positive regulation of glucagon secretion Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. tmpzr1t_l9r_go_relaxed.owl stimulation of glucagon secretion|up-regulation of glucagon secretion|upregulation of glucagon secretion|activation of glucagon secretion|up regulation of glucagon secretion biological_process owl:Class GO:0008701 biolink:NamedThing 4-hydroxy-2-oxovalerate aldolase activity Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. tmpzr1t_l9r_go_relaxed.owl 4-hydroxy-2-oxopentanoate pyruvate-lyase activity|DmpG|4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity|4-hydroxy-2-ketovalerate aldolase activity|4-hydroxy-2-oxovalerate pyruvate-lyase activity|HOA UM-BBD_enzymeID:e0077|KEGG_REACTION:R00750|MetaCyc:MHPELY-RXN|RHEA:22624|EC:4.1.3.39 GO:0018804 molecular_function owl:Class GO:0016833 biolink:NamedThing oxo-acid-lyase activity Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. tmpzr1t_l9r_go_relaxed.owl oxoacid lyase activity|oxo-acid lyase activity EC:4.1.3.- molecular_function owl:Class GO:0050303 biolink:NamedThing lysine 6-dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine. tmpzr1t_l9r_go_relaxed.owl L-lysine:NAD+ 6-oxidoreductase (deaminating)|LysDH activity|L-lysine 6-dehydrogenase activity|L-lysine epsilon-dehydrogenase activity MetaCyc:LYSINE-6-DEHYDROGENASE-RXN|EC:1.4.1.18|RHEA:12408|MetaCyc:PWY-5314 molecular_function owl:Class GO:0016639 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. tmpzr1t_l9r_go_relaxed.owl EC:1.4.1.- molecular_function owl:Class GO:0043318 biolink:NamedThing negative regulation of cytotoxic T cell degranulation Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation. tmpzr1t_l9r_go_relaxed.owl negative regulation of cytotoxic T-cell granule exocytosis|negative regulation of cytotoxic T-lymphocyte granule exocytosis|down-regulation of cytotoxic T cell degranulation|negative regulation of cytotoxic T cell granule exocytosis|negative regulation of cytotoxic T lymphocyte degranulation|negative regulation of cytotoxic T-cell degranulation|negative regulation of cytotoxic T lymphocyte granule exocytosis|down regulation of cytotoxic T cell degranulation|negative regulation of cytotoxic T-lymphocyte degranulation|inhibition of cytotoxic T cell degranulation|downregulation of cytotoxic T cell degranulation biological_process owl:Class GO:0043317 biolink:NamedThing regulation of cytotoxic T cell degranulation Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation. tmpzr1t_l9r_go_relaxed.owl regulation of cytotoxic T lymphocyte degranulation|regulation of cytotoxic T-lymphocyte granule exocytosis|regulation of cytotoxic T-cell granule exocytosis|regulation of cytotoxic T-cell degranulation|regulation of cytotoxic T-lymphocyte degranulation|regulation of cytotoxic T cell granule exocytosis|regulation of cytotoxic T lymphocyte granule exocytosis biological_process owl:Class GO:0071783 biolink:NamedThing endoplasmic reticulum cisternal network organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. tmpzr1t_l9r_go_relaxed.owl ER cisternal network organization|ER cisternal network organisation|endoplasmic reticulum cisternal network organisation mah 2010-09-01T01:47:28Z biological_process owl:Class GO:0007029 biolink:NamedThing endoplasmic reticulum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. tmpzr1t_l9r_go_relaxed.owl endoplasmic reticulum organization and biogenesis|endoplasmic reticulum morphology|ER organisation|endoplasmic reticulum organisation|ER organization and biogenesis biological_process owl:Class GO:2000083 biolink:NamedThing negative regulation of L-ascorbic acid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of L-ascorbic acid biosynthetic process. tmpzr1t_l9r_go_relaxed.owl negative regulation of ascorbate biosynthetic process|negative regulation of vitamin C biosynthetic process|negative regulation of L-ascorbic acid biosynthesis|negative regulation of L-ascorbic acid anabolism|negative regulation of ascorbate biosynthesis|negative regulation of L-ascorbic acid synthesis|negative regulation of L-ascorbic acid formation|negative regulation of vitamin C biosynthesis tb 2010-08-27T11:26:19Z biological_process owl:Class GO:0045912 biolink:NamedThing negative regulation of carbohydrate metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. tmpzr1t_l9r_go_relaxed.owl down-regulation of carbohydrate metabolic process|downregulation of carbohydrate metabolic process|inhibition of carbohydrate metabolic process|negative regulation of carbohydrate metabolism|down regulation of carbohydrate metabolic process biological_process owl:Class GO:0002458 biolink:NamedThing peripheral T cell tolerance induction Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus. tmpzr1t_l9r_go_relaxed.owl peripheral T-cell tolerance induction|peripheral T-lymphocyte tolerance induction|peripheral T lymphocyte tolerance induction biological_process owl:Class GO:0002517 biolink:NamedThing T cell tolerance induction A process involving any mechanism for tolerance induction in T cells. tmpzr1t_l9r_go_relaxed.owl T-cell tolerance induction|T-lymphocyte tolerance induction|T lymphocyte tolerance induction biological_process owl:Class GO:2000177 biolink:NamedThing regulation of neural precursor cell proliferation Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. tmpzr1t_l9r_go_relaxed.owl dph 2010-10-13T12:40:41Z biological_process owl:Class GO:1904712 biolink:NamedThing positive regulation of Wnt-Frizzled-LRP5/6 complex assembly Any process that activates or increases the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly. tmpzr1t_l9r_go_relaxed.owl upregulation of WNT-FZD-LRP6 complex formation|up regulation of Frizzled-LRP5/6 complex assembly|positive regulation of WNT-FZD-LRP5 complex formation|upregulation of WNT-FZD-LRP6 complex assembly|activation of Wnt-induced Frizzled-LRP5/6 complex formation|up regulation of Wnt-FZD-LRP5/6 trimeric complex formation|up regulation of WNT-FZD-LRP5 complex assembly|up regulation of WNT-FZD-LRP6 complex formation|up-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|upregulation of Wnt-induced Frizzled-LRP5/6 complex formation|positive regulation of WNT-FZD-LRP6 complex assembly|upregulation of Wnt-FZD-LRP5/6 trimeric complex assembly|positive regulation of Frizzled-LRP5/6 complex formation|up-regulation of WNT-FZD-LRP5 complex formation|activation of Frizzled-LRP5/6 complex formation|up-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|activation of Wnt-FZD-LRP5/6 trimeric complex assembly|up regulation of WNT-FZD-LRP5 complex formation|activation of Wnt-induced Frizzled-LRP5/6 complex assembly|positive regulation of Frizzled-LRP5/6 complex assembly|up regulation of Frizzled-LRP5/6 complex formation|positive regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|positive regulation of WNT-FZD-LRP5 complex assembly|activation of WNT-FZD-LRP6 complex formation|upregulation of WNT-FZD-LRP5 complex assembly|activation of Wnt-FZD-LRP5/6 trimeric complex formation|positive regulation of WNT-FZD-LRP6 complex formation|up-regulation of Frizzled-LRP5/6 complex formation|up regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|up-regulation of Frizzled-LRP5/6 complex assembly|up-regulation of Wnt-induced Frizzled-LRP5/6 complex formation|positive regulation of Wnt-FZD-LRP5/6 trimeric complex formation|up-regulation of WNT-FZD-LRP6 complex formation|positive regulation of Wnt-induced Frizzled-LRP5/6 complex formation|up-regulation of WNT-FZD-LRP5 complex assembly|up regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|activation of WNT-FZD-LRP6 complex assembly|up regulation of WNT-FZD-LRP6 complex assembly|up-regulation of Wnt-FZD-LRP5/6 trimeric complex formation|upregulation of Frizzled-LRP5/6 complex formation|upregulation of Wnt-induced Frizzled-LRP5/6 complex assembly|up regulation of Wnt-induced Frizzled-LRP5/6 complex formation|activation of Frizzled-LRP5/6 complex assembly|up-regulation of WNT-FZD-LRP6 complex assembly|activation of WNT-FZD-LRP5 complex assembly|upregulation of WNT-FZD-LRP5 complex formation|upregulation of Frizzled-LRP5/6 complex assembly|activation of WNT-FZD-LRP5 complex formation|positive regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|upregulation of Wnt-FZD-LRP5/6 trimeric complex formation bf 2015-10-05T14:02:35Z biological_process owl:Class GO:1904441 biolink:NamedThing regulation of thyroid gland epithelial cell proliferation Any process that modulates the frequency, rate or extent of thyroid gland epithelial cell proliferation. tmpzr1t_l9r_go_relaxed.owl regulation of thyroid follicular cell proliferation|regulation of Hurthle cell proliferation sl 2015-07-06T15:41:09Z biological_process owl:Class GO:0050678 biolink:NamedThing regulation of epithelial cell proliferation Any process that modulates the frequency, rate or extent of epithelial cell proliferation. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:2000131 biolink:NamedThing regulation of tyramine signaling pathway Any process that modulates the frequency, rate or extent of tyramine signaling pathway. tmpzr1t_l9r_go_relaxed.owl regulation of tyramine signalling pathway mah 2010-09-29T09:31:56Z biological_process owl:Class GO:0050759 biolink:NamedThing positive regulation of thymidylate synthase biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. tmpzr1t_l9r_go_relaxed.owl up regulation of thymidylate synthase biosynthetic process|positive regulation of thymidylate synthase formation|activation of thymidylate synthase biosynthetic process|positive regulation of thymidylate synthase biosynthesis|up-regulation of thymidylate synthase biosynthetic process|positive regulation of thymidylate synthase synthesis|stimulation of thymidylate synthase biosynthetic process|positive regulation of thymidylate synthase anabolism|upregulation of thymidylate synthase biosynthetic process biological_process owl:Class GO:0051247 biolink:NamedThing positive regulation of protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. tmpzr1t_l9r_go_relaxed.owl activation of protein metabolic process|positive regulation of protein metabolism|up regulation of protein metabolic process|upregulation of protein metabolic process|up-regulation of protein metabolic process|stimulation of protein metabolic process biological_process owl:Class GO:1904278 biolink:NamedThing positive regulation of wax biosynthetic process Any process that activates or increases the frequency, rate or extent of wax biosynthetic process. tmpzr1t_l9r_go_relaxed.owl up regulation of wax synthesis|positive regulation of wax anabolism|upregulation of wax synthesis|upregulation of wax biosynthesis|upregulation of wax biosynthetic process|activation of wax biosynthetic process|up-regulation of wax biosynthesis|activation of wax biosynthesis|upregulation of wax formation|up-regulation of wax formation|up regulation of wax formation|positive regulation of wax biosynthesis|activation of wax anabolism|up-regulation of wax anabolism|up regulation of wax biosynthetic process|positive regulation of wax synthesis|activation of wax formation|up-regulation of wax biosynthetic process|up regulation of wax anabolism|upregulation of wax anabolism|activation of wax synthesis|positive regulation of wax formation|up-regulation of wax synthesis|up regulation of wax biosynthesis tb 2015-06-03T17:20:19Z biological_process owl:Class GO:0009891 biolink:NamedThing positive regulation of biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. tmpzr1t_l9r_go_relaxed.owl positive regulation of formation|positive regulation of biosynthesis|up-regulation of biosynthetic process|upregulation of biosynthetic process|stimulation of biosynthetic process|positive regulation of synthesis|up regulation of biosynthetic process|activation of biosynthetic process|positive regulation of anabolism biological_process owl:Class GO:0010781 biolink:NamedThing meiotic DNA double-strand break formation involved in meiotic gene conversion The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0042138 biolink:NamedThing meiotic DNA double-strand break formation The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0034356 biolink:NamedThing NAD biosynthesis via nicotinamide riboside salvage pathway The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside. tmpzr1t_l9r_go_relaxed.owl NR salvage pathway|nicotinamide riboside salvage pathway biological_process owl:Class GO:0009435 biolink:NamedThing NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. tmpzr1t_l9r_go_relaxed.owl oxidized nicotinamide adenine dinucleotide biosynthetic process|nicotinamide adenine dinucleotide biosynthesis|NAD biosynthesis|NAD (oxidized) biosynthesis|reduced NAD biosynthetic process|NAD anabolism|NAD (reduced) biosynthetic process|NADH biosynthetic process|NAD formation|reduced nicotinamide adenine dinucleotide biosynthetic process|NADH biosynthesis|NAD synthesis|reduced nicotinamide adenine dinucleotide biosynthesis|NAD (oxidized) biosynthetic process|nicotinamide adenine dinucleotide biosynthetic process|oxidized nicotinamide adenine dinucleotide biosynthesis|oxidized NAD biosynthesis|NAD (reduced) biosynthesis|oxidized NAD biosynthetic process|reduced NAD biosynthesis GO:0006736 biological_process owl:Class GO:0046385 biolink:NamedThing deoxyribose phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. tmpzr1t_l9r_go_relaxed.owl deoxyribose phosphate anabolism|deoxyribose phosphate biosynthesis|deoxyribose phosphate synthesis|deoxyribose phosphate formation biological_process owl:Class GO:0019692 biolink:NamedThing deoxyribose phosphate metabolic process The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. tmpzr1t_l9r_go_relaxed.owl deoxyribose phosphate metabolism biological_process owl:Class GO:0006021 biolink:NamedThing inositol biosynthetic process The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. tmpzr1t_l9r_go_relaxed.owl inositol biosynthesis|inositol formation|inositol anabolism|myo-inositol biosynthesis|myo-inositol biosynthetic process|vitamin Bh biosynthetic process|inositol synthesis|vitamin Bh biosynthesis biological_process owl:Class GO:0006020 biolink:NamedThing inositol metabolic process The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. tmpzr1t_l9r_go_relaxed.owl myo-inositol metabolism|vitamin Bh metabolic process|vitamin Bh metabolism|inositol metabolism|myo-inositol metabolic process Wikipedia:Inositol biological_process owl:Class GO:0019639 biolink:NamedThing 6-hydroxycineole catabolic process The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2. tmpzr1t_l9r_go_relaxed.owl 6-endo-hydroxycineole catabolic process|6-endo-hydroxycineole catabolism|hydroxycineol catabolism|6-hydroxycineole degradation|6-hydroxycineole catabolism|6-hydroxycineole breakdown|hydroxycineol catabolic process MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY biological_process owl:Class GO:1901502 biolink:NamedThing ether catabolic process The chemical reactions and pathways resulting in the breakdown of ether. tmpzr1t_l9r_go_relaxed.owl ether catabolism|ether degradation|ether breakdown pr 2012-10-17T09:42:43Z biological_process owl:Class GO:2001214 biolink:NamedThing positive regulation of vasculogenesis Any process that activates or increases the frequency, rate or extent of vasculogenesis. tmpzr1t_l9r_go_relaxed.owl positive regulation of vascular morphogenesis yaf 2011-11-15T01:22:39Z biological_process owl:Class GO:2001212 biolink:NamedThing regulation of vasculogenesis Any process that modulates the frequency, rate or extent of vasculogenesis. tmpzr1t_l9r_go_relaxed.owl regulation of vascular morphogenesis yaf 2011-11-15T01:22:31Z biological_process owl:Class GO:0018981 biolink:NamedThing triethanolamine metabolic process The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. tmpzr1t_l9r_go_relaxed.owl triethanolamine metabolism UM-BBD_pathwayID:tea biological_process owl:Class GO:0044107 biolink:NamedThing cellular alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl jl 2009-07-15T01:36:19Z biological_process owl:Class GO:1900958 biolink:NamedThing positive regulation of 17-methylnonadec-1-ene biosynthetic process Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process. tmpzr1t_l9r_go_relaxed.owl up-regulation of 17-methylnonadec-1-ene anabolism|up-regulation of 17-methylnonadec-1-ene formation|positive regulation of 17-methylnonadec-1-ene biosynthesis|up-regulation of 17-methylnonadec-1-ene synthesis|up-regulation of 17-methylnonadec-1-ene biosynthesis|activation of 17-methylnonadec-1-ene biosynthesis|up regulation of 17-methylnonadec-1-ene synthesis|upregulation of 17-methylnonadec-1-ene formation|up regulation of 17-methylnonadec-1-ene anabolism|activation of 17-methylnonadec-1-ene formation|upregulation of 17-methylnonadec-1-ene synthesis|up regulation of 17-methylnonadec-1-ene biosynthetic process|up-regulation of 17-methylnonadec-1-ene biosynthetic process|activation of 17-methylnonadec-1-ene anabolism|positive regulation of 17-methylnonadec-1-ene anabolism|positive regulation of 17-methylnonadec-1-ene formation|upregulation of 17-methylnonadec-1-ene anabolism|positive regulation of 17-methylnonadec-1-ene synthesis|activation of 17-methylnonadec-1-ene synthesis|up regulation of 17-methylnonadec-1-ene formation|activation of 17-methylnonadec-1-ene biosynthetic process|upregulation of 17-methylnonadec-1-ene biosynthetic process|up regulation of 17-methylnonadec-1-ene biosynthesis|upregulation of 17-methylnonadec-1-ene biosynthesis tt 2012-06-14T03:27:46Z biological_process owl:Class GO:1900956 biolink:NamedThing regulation of 17-methylnonadec-1-ene biosynthetic process Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of 17-methylnonadec-1-ene formation|regulation of 17-methylnonadec-1-ene anabolism|regulation of 17-methylnonadec-1-ene synthesis|regulation of 17-methylnonadec-1-ene biosynthesis tt 2012-06-14T03:27:18Z biological_process owl:Class GO:0003322 biolink:NamedThing pancreatic A cell development The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. tmpzr1t_l9r_go_relaxed.owl pancreatic alpha cell development dph 2009-11-02T08:13:55Z biological_process owl:Class GO:0010334 biolink:NamedThing sesquiterpene synthase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0010333 biolink:NamedThing terpene synthase activity Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:1900019 biolink:NamedThing regulation of protein kinase C activity Any process that modulates the frequency, rate or extent of protein kinase C activity. tmpzr1t_l9r_go_relaxed.owl regulation of PKC activity|regulation of PKC bf 2012-01-11T03:50:47Z biological_process owl:Class GO:0046493 biolink:NamedThing lipid A metabolic process The chemical reactions and pathways involving lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. tmpzr1t_l9r_go_relaxed.owl lipid A metabolism biological_process owl:Class GO:1901269 biolink:NamedThing lipooligosaccharide metabolic process The chemical reactions and pathways involving lipooligosaccharide. tmpzr1t_l9r_go_relaxed.owl lipooligosaccharide metabolism yaf 2012-08-17T14:31:26Z biological_process owl:Class GO:0001842 biolink:NamedThing neural fold formation The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. tmpzr1t_l9r_go_relaxed.owl neural groove formation biological_process owl:Class GO:0060571 biolink:NamedThing morphogenesis of an epithelial fold The morphogenetic process in which an epithelial sheet bends along a linear axis. tmpzr1t_l9r_go_relaxed.owl folding of an epithelial sheet|epithelial folding dph 2009-04-30T09:27:17Z biological_process owl:Class GO:0006421 biolink:NamedThing asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0006418 biolink:NamedThing tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. tmpzr1t_l9r_go_relaxed.owl tRNA charging MetaCyc:TRNA-CHARGING-PWY biological_process owl:Class GO:1901463 biolink:NamedThing regulation of tetrapyrrole biosynthetic process Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of tetrapyrrole anabolism|regulation of tetrapyrrole biosynthesis|regulation of tetrapyrrole formation|regulation of tetrapyrrole synthesis tt 2012-10-02T14:34:14Z biological_process owl:Class GO:1902723 biolink:NamedThing negative regulation of skeletal muscle satellite cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation. tmpzr1t_l9r_go_relaxed.owl inhibition of satellite cell proliferation|downregulation of satellite cell proliferation|down regulation of satellite cell proliferation|down-regulation of satellite cell proliferation mr 2014-02-24T16:09:46Z biological_process owl:Class GO:0014859 biolink:NamedThing negative regulation of skeletal muscle cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0140491 biolink:NamedThing ubiquitin-like hydrolase activity An activity that cleaves ubiquitin or ubiquitin-like proteins (ULP) from target proteins. tmpzr1t_l9r_go_relaxed.owl ubiquitinyl-like hydrolase activity https://github.com/geneontology/go-ontology/issues/17398 pg 2020-07-01T12:37:19Z molecular_function owl:Class GO:0008233 biolink:NamedThing peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. tmpzr1t_l9r_go_relaxed.owl peptide hydrolase activity|hydrolase, acting on peptide bonds|protease activity|peptidase activity, acting on L-amino acid peptides|peptidase activity, acting on D-amino acid peptides|proteinase activity Reactome:R-HSA-3000243|Reactome:R-HSA-205112|Reactome:R-HSA-6803060|Reactome:R-HSA-5693319|Reactome:R-HSA-376149|Reactome:R-HSA-5684864|Reactome:R-HSA-448678|Reactome:R-HSA-3065959|EC:3.4.-.-|Reactome:R-HSA-3065958|Reactome:R-HSA-5655483|Reactome:R-HSA-5685902|Reactome:R-HSA-4167501|Reactome:R-HSA-3139027 GO:0070011|GO:0070010 molecular_function owl:Class GO:0042573 biolink:NamedThing retinoic acid metabolic process The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. tmpzr1t_l9r_go_relaxed.owl vitamin A1 acid metabolic process|retinoic acid metabolism|vitamin A1 acid metabolism biological_process owl:Class GO:0032787 biolink:NamedThing monocarboxylic acid metabolic process The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). tmpzr1t_l9r_go_relaxed.owl monocarboxylate metabolic process|monocarboxylic acid metabolism biological_process owl:Class GO:0015413 biolink:NamedThing ABC-type nickel transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in). tmpzr1t_l9r_go_relaxed.owl ATPase-coupled nickel transmembrane transporter activity|nickel porter activity|nickel transporting ATPase activity|ATP-dependent nickel transmembrane transporter activity|nickel ABC transporter activity|nickel-transporting ATPase activity|nickel ABC transporter MetaCyc:3.6.3.24-RXN|MetaCyc:ABC-20-RXN|RHEA:15557|EC:7.2.2.11 GO:0102016 molecular_function owl:Class GO:0015099 biolink:NamedThing nickel cation transmembrane transporter activity Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity RHEA:29831 molecular_function owl:Class GO:0051903 biolink:NamedThing S-(hydroxymethyl)glutathione dehydrogenase activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. tmpzr1t_l9r_go_relaxed.owl NAD-dependent formaldehyde dehydrogenase activity|glutathione-dependent formaldehyde dehydrogenase activity|GD-FALDH activity|FDH activity|S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity|chi-ADH activity|NAD-linked formaldehyde dehydrogenase activity|ADH3 activity|NAD- and glutathione-dependent formaldehyde dehydrogenase activity|class III alcohol dehydrogenase activity|GS-FDH activity|formic dehydrogenase activity MetaCyc:RXN-2962|KEGG_REACTION:R07140|Reactome:R-HSA-5692237|KEGG_REACTION:R06983|EC:1.1.1.284|UM-BBD_reactionID:r1146 molecular_function owl:Class GO:0046598 biolink:NamedThing positive regulation of viral entry into host cell Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell. tmpzr1t_l9r_go_relaxed.owl positive regulation of viral penetration into host cell biological_process owl:Class GO:1903902 biolink:NamedThing positive regulation of viral life cycle Any process that activates or increases the frequency, rate or extent of viral life cycle. tmpzr1t_l9r_go_relaxed.owl activation of viral life cycle|up-regulation of viral replication|activation of lytic viral life cycle|up-regulation of lytic viral life cycle|up regulation of viral replication|upregulation of viral life cycle|up-regulation of viral infectious cycle|upregulation of viral assembly, maturation, egress, and release|up regulation of viral assembly, maturation, egress, and release|activation of viral assembly, maturation, egress, and release|positive regulation of viral assembly, maturation, egress, and release|up regulation of viral infectious cycle|upregulation of lytic viral life cycle|positive regulation of lytic viral life cycle|up regulation of viral life cycle|upregulation of viral infectious cycle|activation of viral infectious cycle|positive regulation of viral replication|activation of viral replication|up-regulation of viral life cycle|up regulation of lytic viral life cycle|positive regulation of viral infectious cycle|upregulation of viral replication|up-regulation of viral assembly, maturation, egress, and release pga 2015-02-09T10:22:25Z biological_process owl:Class GO:0030566 biolink:NamedThing snRNA modification guide activity Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue. tmpzr1t_l9r_go_relaxed.owl Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class GO:0017069 biolink:NamedThing snRNA binding Binding to a small nuclear RNA (snRNA). tmpzr1t_l9r_go_relaxed.owl small nuclear RNA binding|base pairing with snRNA GO:0000945 molecular_function owl:Class GO:0006566 biolink:NamedThing threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. tmpzr1t_l9r_go_relaxed.owl methionine and threonine metabolic process|methionine and threonine metabolism|threonine metabolism UM-BBD_pathwayID:met biological_process owl:Class GO:1990124 biolink:NamedThing messenger ribonucleoprotein complex A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules. tmpzr1t_l9r_go_relaxed.owl messenger ribonucleoprotein particle|mRNA-protein complex|mRNP|mRNP complex bf 2013-06-13T09:20:52Z cellular_component owl:Class GO:0043656 biolink:NamedThing host intracellular region That space within the plasma membrane of a host cell. tmpzr1t_l9r_go_relaxed.owl intracellular region of host|host intracellular cellular_component owl:Class GO:0033643 biolink:NamedThing host cell part Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular_component owl:Class GO:1901956 biolink:NamedThing positive regulation of retrograde dense core granule transport Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport. tmpzr1t_l9r_go_relaxed.owl upregulation of retrograde dense core granule transport|activation of retrograde dense core granule transport|up-regulation of retrograde dense core granule transport|up regulation of retrograde dense core granule transport pr 2013-02-19T13:36:52Z biological_process owl:Class GO:0060713 biolink:NamedThing labyrinthine layer morphogenesis The process in which the labyrinthine layer of the placenta is generated and organized. tmpzr1t_l9r_go_relaxed.owl dph 2009-06-10T08:10:19Z biological_process owl:Class GO:0048598 biolink:NamedThing embryonic morphogenesis The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. tmpzr1t_l9r_go_relaxed.owl embryonic anatomical structure morphogenesis GO:0048828 biological_process owl:Class GO:0030649 biolink:NamedThing aminoglycoside antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. tmpzr1t_l9r_go_relaxed.owl aminoglycoside antibiotic breakdown|aminoglycoside antibiotic degradation|aminoglycoside antibiotic catabolism biological_process owl:Class GO:0030647 biolink:NamedThing aminoglycoside antibiotic metabolic process The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. tmpzr1t_l9r_go_relaxed.owl aminoglycoside antibiotic metabolism biological_process owl:Class GO:0003340 biolink:NamedThing negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. tmpzr1t_l9r_go_relaxed.owl dph 2009-11-24T09:46:12Z biological_process owl:Class GO:0003339 biolink:NamedThing regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. tmpzr1t_l9r_go_relaxed.owl dph 2009-11-24T09:43:04Z biological_process owl:Class GO:0103102 biolink:NamedThing UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate <=> H+ + 7-methylthioheptyldesulfoglucosinolate + UDP. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXNQT-4327|EC:2.4.1.195 molecular_function owl:Class GO:0046249 biolink:NamedThing alpha-pinene catabolic process The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. tmpzr1t_l9r_go_relaxed.owl alpha-pinene degradation|alpha-pinene catabolism|alpha-pinene breakdown biological_process owl:Class GO:0033074 biolink:NamedThing pinene catabolic process The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane. tmpzr1t_l9r_go_relaxed.owl pinene catabolism|pinene breakdown|pinene degradation biological_process owl:Class GO:0035176 biolink:NamedThing social behavior Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. tmpzr1t_l9r_go_relaxed.owl social behaviour|cooperative behavior Wikipedia:Social_behavior Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior. biological_process owl:Class GO:0007610 biolink:NamedThing behavior The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. tmpzr1t_l9r_go_relaxed.owl behavioural response to stimulus|single-organism behavior|behaviour|behavioral response to stimulus Wikipedia:Behavior 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. 2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). jl 2012-09-20T14:06:08Z GO:0023032|GO:0044708|GO:0044709 biological_process owl:Class GO:0042480 biolink:NamedThing negative regulation of eye photoreceptor cell development Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. tmpzr1t_l9r_go_relaxed.owl down-regulation of eye photoreceptor cell development|downregulation of eye photoreceptor cell development|down regulation of eye photoreceptor cell development|negative regulation of eye photoreceptor development|inhibition of eye photoreceptor cell development biological_process owl:Class GO:0021770 biolink:NamedThing parahippocampal gyrus development The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex. tmpzr1t_l9r_go_relaxed.owl hippocampal gyrus development Wikipedia:parahippocampal_gyrus biological_process owl:Class GO:0048856 biolink:NamedThing anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. tmpzr1t_l9r_go_relaxed.owl development of an anatomical structure biological_process owl:Class GO:0120086 biolink:NamedThing (3S)-(+)-asterisca-2(9),6-diene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene. tmpzr1t_l9r_go_relaxed.owl asterisca-2(9),6-diene synthase activity krc 2017-08-02T14:55:38Z molecular_function owl:Class GO:0051947 biolink:NamedThing regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. tmpzr1t_l9r_go_relaxed.owl regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|regulation of 4-aminobutyrate reuptake|regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse|regulation of GABA uptake during transmission of nerve impulse|regulation of GABA reuptake|regulation of 4-aminobutyrate uptake during transmission of nerve impulse|regulation of gamma-aminobutyric acid reuptake biological_process owl:Class GO:0033690 biolink:NamedThing positive regulation of osteoblast proliferation Any process that activates or increases the rate or extent of osteoblast proliferation. tmpzr1t_l9r_go_relaxed.owl up regulation of osteoblast proliferation|stimulation of osteoblast proliferation|up-regulation of osteoblast proliferation|upregulation of osteoblast proliferation|activation of osteoblast proliferation biological_process owl:Class GO:1904398 biolink:NamedThing positive regulation of neuromuscular junction development Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. tmpzr1t_l9r_go_relaxed.owl up-regulation of neuromuscular junction stability|up regulation of neuromuscular junction stability|up-regulation of neuromuscular junction development|up regulation of neuromuscular junction development|upregulation of neuromuscular junction organization|activation of neuromuscular junction organization|activation of neuromuscular junction stability|positive regulation of neuromuscular junction stability|upregulation of neuromuscular junction stability|up-regulation of NMJ stability|activation of neuromuscular junction development|up-regulation of neuromuscular junction organization|upregulation of NMJ stability|upregulation of neuromuscular junction development|activation of NMJ stability|positive regulation of NMJ stability|up regulation of NMJ stability|positive regulation of neuromuscular junction organization|up regulation of neuromuscular junction organization sl 2015-06-23T19:23:54Z biological_process owl:Class GO:1904396 biolink:NamedThing regulation of neuromuscular junction development Any process that modulates the frequency, rate or extent of neuromuscular junction development. tmpzr1t_l9r_go_relaxed.owl regulation of neuromuscular junction organization|regulation of neuromuscular junction stability|regulation of NMJ stability sl 2015-06-23T19:23:42Z biological_process owl:Class GO:0070507 biolink:NamedThing regulation of microtubule cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. tmpzr1t_l9r_go_relaxed.owl regulation of microtubule cytoskeleton organisation|regulation of microtubule dynamics biological_process owl:Class GO:0032886 biolink:NamedThing regulation of microtubule-based process Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0046643 biolink:NamedThing regulation of gamma-delta T cell activation Any process that modulates the frequency, rate or extent of gamma-delta T cell activation. tmpzr1t_l9r_go_relaxed.owl regulation of gamma-delta T-cell activation|regulation of gamma-delta T lymphocyte activation|regulation of gamma-delta T-lymphocyte activation biological_process owl:Class GO:0004331 biolink:NamedThing fructose-2,6-bisphosphate 2-phosphatase activity Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. tmpzr1t_l9r_go_relaxed.owl D-fructose-2,6-bisphosphate 2-phosphohydrolase activity|fructose-2,6-bisphosphatase activity|beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity Reactome:R-HSA-5628905|MetaCyc:3.1.3.46-RXN|EC:3.1.3.46|Reactome:R-HSA-70262|RHEA:17289 GO:0004330 molecular_function owl:Class GO:0050308 biolink:NamedThing sugar-phosphatase activity Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. tmpzr1t_l9r_go_relaxed.owl sugar-phosphate phosphatase activity|sugar-phosphate phosphohydrolase activity EC:3.1.3.23|MetaCyc:SUGAR-PHOSPHATASE-RXN|KEGG_REACTION:R00804 molecular_function owl:Class GO:0048239 biolink:NamedThing negative regulation of DNA recombination at telomere Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere. tmpzr1t_l9r_go_relaxed.owl negative regulation of telomeric recombination at telomere|downregulation of telomeric recombination at telomere|down-regulation of telomeric recombination at telomere|suppression of telomeric recombination at telomere|down regulation of telomeric recombination at telomere|inhibition of telomeric recombination at telomere biological_process owl:Class GO:0045910 biolink:NamedThing negative regulation of DNA recombination Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. tmpzr1t_l9r_go_relaxed.owl down-regulation of DNA recombination|down regulation of DNA recombination|downregulation of DNA recombination|inhibition of DNA recombination biological_process owl:Class GO:0009699 biolink:NamedThing phenylpropanoid biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid. tmpzr1t_l9r_go_relaxed.owl phenylpropanoid biosynthesis|phenylpropanoid formation|phenylpropanoid anabolism|phenylpropanoid synthesis biological_process owl:Class GO:0007165 biolink:NamedThing signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. tmpzr1t_l9r_go_relaxed.owl signaling cascade|signalling cascade|signal transduction by trans-phosphorylation|signaling pathway|signal transduction by cis-phosphorylation|signal transduction by protein phosphorylation|signal transduction by conformational transition|signalling pathway Wikipedia:Signal_transduction Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. GO:0023015|GO:0023014|GO:0023045|GO:0023016|GO:0023033 biological_process owl:Class GO:0050794 biolink:NamedThing regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. tmpzr1t_l9r_go_relaxed.owl regulation of cellular physiological process GO:0051244 biological_process owl:Class GO:1903678 biolink:NamedThing negative regulation of cap-independent translational initiation Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation. tmpzr1t_l9r_go_relaxed.owl down-regulation of cap-independent translational initiation|downregulation of cap-independent translational initiation|inhibition of cap-independent translational initiation|down regulation of cap-independent translational initiation bf 2014-11-27T19:52:28Z biological_process owl:Class GO:1903677 biolink:NamedThing regulation of cap-independent translational initiation Any process that modulates the frequency, rate or extent of cap-independent translational initiation. tmpzr1t_l9r_go_relaxed.owl bf 2014-11-27T19:52:20Z biological_process owl:Class GO:1904522 biolink:NamedThing positive regulation of myofibroblast cell apoptotic process Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process. tmpzr1t_l9r_go_relaxed.owl up-regulation of MFB apoptosis|positive regulation of myofibroblast cell apoptosis|positive regulation of MFB apoptosis|up regulation of MFB apoptotic process|activation of MFB apoptotic process|positive regulation of MFB apoptotic process|up-regulation of myofibroblast cell apoptotic process|up-regulation of MFB apoptotic process|upregulation of myofibroblast cell apoptotic process|up regulation of myofibroblast cell apoptosis|upregulation of MFB apoptosis|upregulation of myofibroblast cell apoptosis|activation of MFB apoptosis|activation of myofibroblast cell apoptosis|activation of myofibroblast cell apoptotic process|up-regulation of myofibroblast cell apoptosis|upregulation of MFB apoptotic process|up regulation of myofibroblast cell apoptotic process|up regulation of MFB apoptosis sl 2015-07-29T15:52:26Z biological_process owl:Class GO:0003431 biolink:NamedThing growth plate cartilage chondrocyte development The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell. tmpzr1t_l9r_go_relaxed.owl dph 2009-12-22T12:32:49Z biological_process owl:Class GO:0003433 biolink:NamedThing chondrocyte development involved in endochondral bone morphogenesis The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. tmpzr1t_l9r_go_relaxed.owl dph 2009-12-22T12:42:44Z biological_process owl:Class GO:0043128 biolink:NamedThing positive regulation of 1-phosphatidylinositol 4-kinase activity Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase. tmpzr1t_l9r_go_relaxed.owl up-regulation of 1-phosphatidylinositol 4-kinase activity|stimulation of 1-phosphatidylinositol 4-kinase activity|activation of 1-phosphatidylinositol 4-kinase activity|up regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of PI4K activity|upregulation of 1-phosphatidylinositol 4-kinase activity biological_process owl:Class GO:0090218 biolink:NamedThing positive regulation of lipid kinase activity Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. tmpzr1t_l9r_go_relaxed.owl tb 2010-01-12T10:18:30Z biological_process owl:Class GO:1901599 biolink:NamedThing (-)-pinoresinol biosynthetic process The chemical reactions and pathways resulting in the formation of (-)-pinoresinol. tmpzr1t_l9r_go_relaxed.owl (-)-pinoresinol formation|(-)-pinoresinol anabolism|(-)-pinoresinol biosynthesis|(-)-pinoresinol synthesis tb 2012-11-08T01:16:05Z biological_process owl:Class GO:0046189 biolink:NamedThing phenol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. tmpzr1t_l9r_go_relaxed.owl phenol-containing compound synthesis|phenol-containing compound formation|phenol-containing compound anabolism|phenol-containing compound biosynthesis biological_process owl:Class GO:1900997 biolink:NamedThing benzene biosynthetic process The chemical reactions and pathways resulting in the formation of benzene. tmpzr1t_l9r_go_relaxed.owl benzene synthesis|benzene formation|benzene biosynthesis|benzene anabolism yaf 2012-06-14T02:54:01Z biological_process owl:Class GO:1903851 biolink:NamedThing negative regulation of cristae formation Any process that stops, prevents or reduces the frequency, rate or extent of cristae formation. tmpzr1t_l9r_go_relaxed.owl down regulation of cristae formation|down-regulation of cristae formation|inhibition of cristae formation|downregulation of cristae formation AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype pad 2015-01-27T09:42:33Z biological_process owl:Class GO:1903850 biolink:NamedThing regulation of cristae formation Any process that modulates the frequency, rate or extent of cristae formation. tmpzr1t_l9r_go_relaxed.owl AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype pad 2015-01-27T09:42:23Z biological_process owl:Class GO:1901983 biolink:NamedThing regulation of protein acetylation Any process that modulates the frequency, rate or extent of protein acetylation. tmpzr1t_l9r_go_relaxed.owl regulation of protein amino acid acetylation ss 2013-03-14T00:40:07Z biological_process owl:Class GO:0031399 biolink:NamedThing regulation of protein modification process Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0032567 biolink:NamedThing dGTP binding Binding to dGTP, deoxyguanosine triphosphate. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0032560 biolink:NamedThing guanyl deoxyribonucleotide binding Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0044758 biolink:NamedThing modulation by symbiont of host synaptic transmission Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism. tmpzr1t_l9r_go_relaxed.owl regulation by symbiont of host synaptic transmission jl 2012-12-06T15:34:05Z biological_process owl:Class GO:0044068 biolink:NamedThing modulation by symbiont of host cellular process Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. tmpzr1t_l9r_go_relaxed.owl modulation of host cellular process by symbiont|regulation of host cellular process by symbiont|regulation by symbiont of host cellular process biological_process owl:Class GO:0035579 biolink:NamedThing specific granule membrane The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. tmpzr1t_l9r_go_relaxed.owl secondary granule membrane bf 2010-10-05T01:32:47Z cellular_component owl:Class GO:0030667 biolink:NamedThing secretory granule membrane The lipid bilayer surrounding a secretory granule. tmpzr1t_l9r_go_relaxed.owl secretory vesicle membrane cellular_component owl:Class GO:1903852 biolink:NamedThing positive regulation of cristae formation Any process that activates or increases the frequency, rate or extent of cristae formation. tmpzr1t_l9r_go_relaxed.owl up regulation of cristae formation|activation of cristae formation|up-regulation of cristae formation|upregulation of cristae formation AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype pad 2015-01-27T09:42:42Z biological_process owl:Class GO:0010822 biolink:NamedThing positive regulation of mitochondrion organization Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. tmpzr1t_l9r_go_relaxed.owl positive regulation of mitochondrion organisation biological_process owl:Class GO:0032811 biolink:NamedThing negative regulation of epinephrine secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine. tmpzr1t_l9r_go_relaxed.owl down-regulation of epinephrine secretion|negative regulation of adrenaline secretion|down regulation of epinephrine secretion|inhibition of epinephrine secretion|downregulation of epinephrine secretion biological_process owl:Class GO:0033604 biolink:NamedThing negative regulation of catecholamine secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. tmpzr1t_l9r_go_relaxed.owl down-regulation of catecholamine secretion|downregulation of catecholamine secretion|down regulation of catecholamine secretion|inhibition of catecholamine secretion biological_process owl:Class GO:0102794 biolink:NamedThing cinnamaldehyde:oxygen oxidoreductase activity Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-8089|EC:1.2.3.9 molecular_function owl:Class GO:0016623 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen. tmpzr1t_l9r_go_relaxed.owl EC:1.2.3.- molecular_function owl:Class GO:0101006 biolink:NamedThing protein histidine phosphatase activity Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. tmpzr1t_l9r_go_relaxed.owl phosphohistidine phosphatase activity https://github.com/geneontology/go-ontology/issues/21517 EC:3.9.1.3|RHEA:47964 This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the pros- (RHEA:47964) and tele- (RHEA:47960) nitrogen atoms, but the pros- position is somewhat preferred (by a factor of two at the most) (EC:3.9.1.3). GO:0008969 molecular_function owl:Class GO:0016825 biolink:NamedThing hydrolase activity, acting on acid phosphorus-nitrogen bonds Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond. tmpzr1t_l9r_go_relaxed.owl EC:3.9.1.- molecular_function owl:Class GO:0030811 biolink:NamedThing regulation of nucleotide catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. tmpzr1t_l9r_go_relaxed.owl regulation of nucleotide catabolism|regulation of nucleotide breakdown|regulation of nucleotide degradation biological_process owl:Class GO:0034614 biolink:NamedThing cellular response to reactive oxygen species Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. tmpzr1t_l9r_go_relaxed.owl cellular response to AOS|cellular response to ROI|cellular response to reactive oxygen intermediate|cellular response to reactive oxidative species|cellular response to active oxygen species|cellular response to ROS biological_process owl:Class GO:0034599 biolink:NamedThing cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. tmpzr1t_l9r_go_relaxed.owl adaptive response to oxidative stress biological_process owl:Class GO:0018970 biolink:NamedThing toluene metabolic process The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications. tmpzr1t_l9r_go_relaxed.owl methylbenzene metabolic process|toluene metabolism|methylbenzene metabolism biological_process owl:Class GO:0072490 biolink:NamedThing toluene-containing compound metabolic process The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives. tmpzr1t_l9r_go_relaxed.owl toluene-containing compound metabolism|toluene and derivative metabolic process mah 2010-12-14T03:46:52Z biological_process owl:Class GO:0046471 biolink:NamedThing phosphatidylglycerol metabolic process The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. tmpzr1t_l9r_go_relaxed.owl phosphatidylglycerol metabolism biological_process owl:Class GO:0006650 biolink:NamedThing glycerophospholipid metabolic process The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. tmpzr1t_l9r_go_relaxed.owl glycerophospholipid metabolism|phosphoglyceride metabolic process|phosphoglyceride metabolism|alpha-glycerophosphate pathway GO:0006652 biological_process owl:Class GO:0002345 biolink:NamedThing peripheral B cell receptor editing The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation. tmpzr1t_l9r_go_relaxed.owl peripheral B-cell receptor editing|peripheral B-lymphocyte receptor editing|peripheral B lymphocyte receptor editing biological_process owl:Class GO:0019686 biolink:NamedThing purine nucleoside interconversion The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0015949 biolink:NamedThing nucleobase-containing small molecule interconversion The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. tmpzr1t_l9r_go_relaxed.owl MetaCyc:P1-PWY biological_process owl:Class GO:0047478 biolink:NamedThing aspartate-ammonia ligase (ADP-forming) activity Catalysis of the reaction: L-aspartate + ATP + NH(4)(+) = L-asparagine + ADP + 2 H(+) + phosphate. tmpzr1t_l9r_go_relaxed.owl asparagine synthetase (ADP-forming) activity|asparagine synthetase (adenosine diphosphate-forming)|L-aspartate:ammonia ligase (ADP-forming) EC:6.3.1.4|MetaCyc:6.3.1.4-RXN|RHEA:14197|KEGG_REACTION:R00482 molecular_function owl:Class GO:0016880 biolink:NamedThing acid-ammonia (or amide) ligase activity Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. tmpzr1t_l9r_go_relaxed.owl amide synthase activity EC:6.3.1.- molecular_function owl:Class GO:0017190 biolink:NamedThing N-terminal peptidyl-aspartic acid acetylation The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase. tmpzr1t_l9r_go_relaxed.owl RESID:AA0042 See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. biological_process owl:Class GO:0018197 biolink:NamedThing peptidyl-aspartic acid modification The modification of peptidyl-aspartic acid. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0051170 biolink:NamedThing import into nucleus The directed movement of substances into the nucleus. tmpzr1t_l9r_go_relaxed.owl single-organism nuclear import|nuclear import|substance nuclear import|single organism nuclear import jl 2013-12-19T15:26:34Z GO:1902593 biological_process owl:Class GO:0006913 biolink:NamedThing nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. tmpzr1t_l9r_go_relaxed.owl nucleocytoplasmic shuttling Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. GO:0000063 biological_process owl:Class GO:0014895 biolink:NamedThing smooth muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0014805 biolink:NamedThing smooth muscle adaptation Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. tmpzr1t_l9r_go_relaxed.owl smooth muscle plasticity biological_process owl:Class GO:0071247 biolink:NamedThing cellular response to chromate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2009-12-03T02:46:01Z biological_process owl:Class GO:0071241 biolink:NamedThing cellular response to inorganic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2009-12-03T02:35:49Z biological_process owl:Class GO:0071297 biolink:NamedThing cellular response to cobalamin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to vitamin B12 mah 2009-12-10T04:28:45Z biological_process owl:Class GO:1901701 biolink:NamedThing cellular response to oxygen-containing compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to oxygen molecular entity pr 2012-12-13T15:11:42Z biological_process owl:Class GO:0048481 biolink:NamedThing plant ovule development The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0099402 biolink:NamedThing plant organ development Development of a plant organ, a multi-tissue plant structure that forms a functional unit. tmpzr1t_l9r_go_relaxed.owl development of a plant organ biological_process owl:Class GO:0047575 biolink:NamedThing 4-carboxymuconolactone decarboxylase activity Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = 5-oxo-4,5-dihydro-2-furylacetate + CO(2). tmpzr1t_l9r_go_relaxed.owl 4-carboxymuconolactone carboxy-lyase activity|4-carboxymonolactone carboxy-lyase activity|4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)|gamma-4-carboxymuconolactone decarboxylase activity EC:4.1.1.44|MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN|KEGG_REACTION:R03470|RHEA:23348 molecular_function owl:Class GO:0016831 biolink:NamedThing carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. tmpzr1t_l9r_go_relaxed.owl decarboxylase activity EC:4.1.1.-|Reactome:R-HSA-71223|Reactome:R-HSA-6814165|Reactome:R-HSA-6787757 molecular_function owl:Class GO:0102346 biolink:NamedThing 3-hydroxy-cerotoyl-CoA dehydratase activity Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA(4-) <=> trans-2-hexacosenoyl-CoA(4-) + H2O. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-13305 molecular_function owl:Class GO:0051942 biolink:NamedThing negative regulation of amino acid uptake involved in synaptic transmission Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. tmpzr1t_l9r_go_relaxed.owl negative regulation of amino acid neurotransmitter uptake|inhibition of amino acid uptake during transmission of nerve impulse|downregulation of amino acid uptake during transmission of nerve impulse|down-regulation of amino acid uptake during transmission of nerve impulse|down regulation of amino acid uptake during transmission of nerve impulse|negative regulation of amino acid uptake during transmission of nerve impulse|negative regulation of amino acid neurotransmitter reuptake biological_process owl:Class GO:0072564 biolink:NamedThing blood microparticle formation The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. tmpzr1t_l9r_go_relaxed.owl microparticle generation|microparticle release mah 2011-01-28T02:15:50Z biological_process owl:Class GO:0016043 biolink:NamedThing cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. tmpzr1t_l9r_go_relaxed.owl cellular component organisation in other organism|cellular component organization at cellular level|cell organization and biogenesis|cellular component organization in other organism|cellular component organisation at cellular level|cell organisation GO:0044235|GO:0071842 biological_process owl:Class GO:0050522 biolink:NamedThing oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP. tmpzr1t_l9r_go_relaxed.owl EC:1.20.98.- molecular_function owl:Class GO:0030613 biolink:NamedThing oxidoreductase activity, acting on phosphorus or arsenic in donors Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. tmpzr1t_l9r_go_relaxed.owl oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors EC:1.20.-.- molecular_function owl:Class GO:0033699 biolink:NamedThing DNA 5'-adenosine monophosphate hydrolase activity Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus. tmpzr1t_l9r_go_relaxed.owl DNA deadenylation|AMP-removal activity|DNA 5'-adenylate hydrolase activity|DNA adenylate hydrolysis activity|DNA de-adenylation molecular_function owl:Class GO:0035312 biolink:NamedThing 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0008328 biolink:NamedThing ionotropic glutamate receptor complex A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0098878 biolink:NamedThing neurotransmitter receptor complex Any protein complex that is capable of functioning as a neurotransmitter receptor. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:1990308 biolink:NamedThing type-I dockerin domain binding Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain. tmpzr1t_l9r_go_relaxed.owl tt 2014-03-07T03:10:37Z molecular_function owl:Class GO:0035492 biolink:NamedThing negative regulation of leukotriene production involved in inflammatory response Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. tmpzr1t_l9r_go_relaxed.owl bf 2010-04-26T10:50:55Z biological_process owl:Class GO:0050728 biolink:NamedThing negative regulation of inflammatory response Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. tmpzr1t_l9r_go_relaxed.owl down regulation of inflammatory response|inhibition of inflammatory response|downregulation of inflammatory response|down-regulation of inflammatory response|anti-inflammatory response GO:0030236 biological_process owl:Class GO:0002835 biolink:NamedThing negative regulation of response to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell. tmpzr1t_l9r_go_relaxed.owl inhibition of response to tumor cell|downregulation of response to tumor cell|down-regulation of response to tumor cell|down regulation of response to tumor cell|negative regulation of response to tumour cell biological_process owl:Class GO:0010958 biolink:NamedThing regulation of amino acid import across plasma membrane Any process that modulates the frequency, rate or extent of amino acid import into a cell. tmpzr1t_l9r_go_relaxed.owl regulation of amino acid import tb 2009-05-06T11:33:12Z biological_process owl:Class GO:0070795 biolink:NamedThing positive regulation of conidiophore development Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. tmpzr1t_l9r_go_relaxed.owl mah 2009-07-08T03:08:29Z biological_process owl:Class GO:0070793 biolink:NamedThing regulation of conidiophore development Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. tmpzr1t_l9r_go_relaxed.owl mah 2009-07-08T03:04:29Z biological_process owl:Class GO:0071075 biolink:NamedThing CUGBP1-eIF2 complex A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation. tmpzr1t_l9r_go_relaxed.owl mah 2009-11-06T01:43:30Z cellular_component owl:Class GO:0042479 biolink:NamedThing positive regulation of eye photoreceptor cell development Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. tmpzr1t_l9r_go_relaxed.owl stimulation of eye photoreceptor cell development|activation of eye photoreceptor cell development|up-regulation of eye photoreceptor cell development|up regulation of eye photoreceptor cell development|upregulation of eye photoreceptor cell development|positive regulation of eye photoreceptor development biological_process owl:Class GO:0010720 biolink:NamedThing positive regulation of cell development Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:2000233 biolink:NamedThing negative regulation of rRNA processing Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing. tmpzr1t_l9r_go_relaxed.owl negative regulation of 35S primary transcript processing mah 2010-11-10T12:11:33Z biological_process owl:Class GO:0051253 biolink:NamedThing negative regulation of RNA metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. tmpzr1t_l9r_go_relaxed.owl down-regulation of RNA metabolic process|down regulation of RNA metabolic process|downregulation of RNA metabolic process|inhibition of RNA metabolic process|negative regulation of RNA metabolism biological_process owl:Class GO:2000569 biolink:NamedThing regulation of T-helper 2 cell activation Any process that modulates the frequency, rate or extent of T-helper 2 cell activation. tmpzr1t_l9r_go_relaxed.owl regulation of Th2 cell activation ebc 2011-04-03T09:14:53Z biological_process owl:Class GO:2000514 biolink:NamedThing regulation of CD4-positive, alpha-beta T cell activation Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. tmpzr1t_l9r_go_relaxed.owl ebc 2011-03-22T10:36:56Z biological_process owl:Class GO:0000209 biolink:NamedThing protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. tmpzr1t_l9r_go_relaxed.owl protein polyubiquitylation|protein polyubiquitinylation|polyubiquitin biological_process owl:Class GO:0016567 biolink:NamedThing protein ubiquitination The process in which one or more ubiquitin groups are added to a protein. tmpzr1t_l9r_go_relaxed.owl protein ubiquitinylation|protein ubiquitylation biological_process owl:Class GO:0045662 biolink:NamedThing negative regulation of myoblast differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. tmpzr1t_l9r_go_relaxed.owl inhibition of myoblast differentiation|down regulation of myoblast differentiation|down-regulation of myoblast differentiation|downregulation of myoblast differentiation biological_process owl:Class GO:0045661 biolink:NamedThing regulation of myoblast differentiation Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0045835 biolink:NamedThing negative regulation of meiotic nuclear division Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. tmpzr1t_l9r_go_relaxed.owl downregulation of meiosis|down-regulation of meiosis|negative regulation of meiosis|inhibition of meiosis|down regulation of meiosis biological_process owl:Class GO:0051447 biolink:NamedThing negative regulation of meiotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. tmpzr1t_l9r_go_relaxed.owl inhibition of progression through meiotic cell cycle|down-regulation of progression through meiotic cell cycle|downregulation of progression through meiotic cell cycle|down regulation of progression through meiotic cell cycle|negative regulation of progression through meiotic cell cycle|negative regulation of meiotic cell cycle progression biological_process owl:Class GO:0052862 biolink:NamedThing glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. tmpzr1t_l9r_go_relaxed.owl laminaranase activity|laminarinase activity|1,3-(1,4)-beta-D-glucan 4-glucanohydrolase activity MetaCyc:3.2.1.6-RXN|EC:3.2.1.6 ai 2011-12-06T05:27:26Z molecular_function owl:Class GO:0052736 biolink:NamedThing beta-glucanase activity Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds. tmpzr1t_l9r_go_relaxed.owl beta-D-glucanase activity 2011-08-19T03:40:56Z molecular_function owl:Class GO:0021551 biolink:NamedThing central nervous system morphogenesis The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0006463 biolink:NamedThing steroid hormone receptor complex assembly The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0034622 biolink:NamedThing cellular protein-containing complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. tmpzr1t_l9r_go_relaxed.owl cellular protein complex assembly|cellular macromolecule complex assembly GO:0043623 biological_process owl:Class GO:0043583 biolink:NamedThing ear development The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. tmpzr1t_l9r_go_relaxed.owl hearing organ development biological_process owl:Class GO:0007423 biolink:NamedThing sensory organ development The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. tmpzr1t_l9r_go_relaxed.owl sense organ development biological_process owl:Class GO:0002858 biolink:NamedThing regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1990814 biolink:NamedThing DNA/DNA annealing activity An activity that faciliates the formation of a complementary double-stranded DNA molecule. tmpzr1t_l9r_go_relaxed.owl DNA reannealing activity https://github.com/geneontology/go-ontology/issues/2161 vw 2015-07-29T12:35:03Z molecular_function owl:Class GO:0140666 biolink:NamedThing annealing activity An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule. tmpzr1t_l9r_go_relaxed.owl renaturation https://github.com/geneontology/go-ontology/issues/21614 pr 2014-06-13T10:18:43Z GO:0097617 molecular_function owl:Class GO:1900613 biolink:NamedThing F-9775B catabolic process The chemical reactions and pathways resulting in the breakdown of F-9775B. tmpzr1t_l9r_go_relaxed.owl F-9775B catabolism|F-9775B degradation|F-9775B breakdown di 2012-05-15T07:03:24Z biological_process owl:Class GO:1901377 biolink:NamedThing organic heteropentacyclic compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic heteropentacyclic compound. tmpzr1t_l9r_go_relaxed.owl organic heteropentacyclic compound breakdown|organic heteropentacyclic compound catabolism|organic heteropentacyclic compound degradation bf 2012-09-28T12:51:51Z biological_process owl:Class GO:0097196 biolink:NamedThing Shu complex A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p. tmpzr1t_l9r_go_relaxed.owl pr 2011-12-01T05:11:08Z cellular_component owl:Class GO:1990391 biolink:NamedThing DNA repair complex A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. tmpzr1t_l9r_go_relaxed.owl DNA damage repair complex|WHY1 complex bhm 2014-06-04T09:15:24Z cellular_component owl:Class GO:0043451 biolink:NamedThing alkene catabolic process The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n. tmpzr1t_l9r_go_relaxed.owl alkene breakdown|alkene degradation|alkene catabolism biological_process owl:Class GO:0043449 biolink:NamedThing cellular alkene metabolic process The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl alkene metabolism biological_process owl:Class GO:1904266 biolink:NamedThing regulation of Schwann cell chemotaxis Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis. tmpzr1t_l9r_go_relaxed.owl sl 2015-05-28T17:47:41Z biological_process owl:Class GO:0050920 biolink:NamedThing regulation of chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0019619 biolink:NamedThing 3,4-dihydroxybenzoate catabolic process The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. tmpzr1t_l9r_go_relaxed.owl protocatechuate degradation|protocatechuate catabolic process|protocatechuate breakdown|protocatechuate catabolism biological_process owl:Class GO:0034362 biolink:NamedThing low-density lipoprotein particle A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. tmpzr1t_l9r_go_relaxed.owl LDL particle|LDL complex|low-density lipoprotein complex cellular_component owl:Class GO:0034358 biolink:NamedThing plasma lipoprotein particle A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0032819 biolink:NamedThing positive regulation of natural killer cell proliferation Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation. tmpzr1t_l9r_go_relaxed.owl stimulation of natural killer cell proliferation|up-regulation of natural killer cell proliferation|upregulation of natural killer cell proliferation|up regulation of natural killer cell proliferation|activation of natural killer cell proliferation|positive regulation of NK cell proliferation biological_process owl:Class GO:0032817 biolink:NamedThing regulation of natural killer cell proliferation Any process that modulates the frequency, rate or extent of natural killer cell proliferation. tmpzr1t_l9r_go_relaxed.owl regulation of NK cell proliferation biological_process owl:Class GO:0071541 biolink:NamedThing eukaryotic translation initiation factor 3 complex, eIF3m An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. tmpzr1t_l9r_go_relaxed.owl eIF3m-containing eukaryotic translation initiation factor 3 complex mah 2010-01-12T02:26:41Z cellular_component owl:Class GO:0005852 biolink:NamedThing eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. tmpzr1t_l9r_go_relaxed.owl eIF-3|eIF3 cellular_component owl:Class GO:0086046 biolink:NamedThing membrane depolarization during SA node cell action potential The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. tmpzr1t_l9r_go_relaxed.owl membrane depolarization involved in regulation of SAN cardiac muscle cell action potential|membrane depolarization involved in regulation of SA node cardiac muscle cell action potential|membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential|membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential dph 2011-11-16T10:52:57Z biological_process owl:Class GO:0051899 biolink:NamedThing membrane depolarization The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:2000815 biolink:NamedThing regulation of mRNA stability involved in response to oxidative stress A process of regulation of mRNA stability that is involved in a response to oxidative stress. tmpzr1t_l9r_go_relaxed.owl mah 2011-07-11T04:40:56Z biological_process owl:Class GO:0010610 biolink:NamedThing regulation of mRNA stability involved in response to stress Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1902248 biolink:NamedThing 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding Binding to 5-O-phosphono-alpha-D-ribofuranosyl diphosphate. tmpzr1t_l9r_go_relaxed.owl 5-phosphoribose 1-diphosphate binding|phosphoribosylpyrophosphate binding mah 2013-06-20T16:20:29Z molecular_function owl:Class GO:0097367 biolink:NamedThing carbohydrate derivative binding Binding to a carbohydrate derivative. tmpzr1t_l9r_go_relaxed.owl pr 2012-08-02T13:03:39Z molecular_function owl:Class GO:0000462 biolink:NamedThing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. tmpzr1t_l9r_go_relaxed.owl maturation of 18S rRNA GO:1990041 biological_process owl:Class GO:0030490 biolink:NamedThing maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. tmpzr1t_l9r_go_relaxed.owl processing of 20S pre-rRNA|SSU-rRNA maturation biological_process owl:Class GO:1903755 biolink:NamedThing positive regulation of SUMO transferase activity Any process that activates or increases the frequency, rate or extent of SUMO transferase activity. tmpzr1t_l9r_go_relaxed.owl up-regulation of SUMO conjugating enzyme activity|activation of SUMO transferase activity|up-regulation of SUMO transferase activity|up-regulation of SMT3 conjugating enzyme|upregulation of SUMO conjugating enzyme activity|upregulation of SMT3 conjugating enzyme|positive regulation of SUMO conjugating enzyme activity|upregulation of SUMO transferase activity|up regulation of SMT3 conjugating enzyme|up regulation of SUMO conjugating enzyme activity|activation of SUMO conjugating enzyme activity|positive regulation of SMT3 conjugating enzyme|up regulation of SUMO transferase activity|activation of SMT3 conjugating enzyme rl 2014-12-18T13:05:59Z biological_process owl:Class GO:1903182 biolink:NamedThing regulation of SUMO transferase activity Any process that modulates the frequency, rate or extent of SUMO ligase activity. tmpzr1t_l9r_go_relaxed.owl regulation of SUMO conjugating enzyme activity|regulation of SMT3 conjugating enzyme bf 2014-07-14T14:01:40Z biological_process owl:Class GO:1903448 biolink:NamedThing geraniol biosynthetic process The chemical reactions and pathways resulting in the formation of geraniol. tmpzr1t_l9r_go_relaxed.owl geraniol synthesis|geraniol anabolism|geraniol biosynthesis|geraniol formation di 2014-09-19T08:18:52Z biological_process owl:Class GO:0120255 biolink:NamedThing olefinic compound biosynthetic process The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). tmpzr1t_l9r_go_relaxed.owl alkene substituted compound biosynthetic process|alkene substituted compound synthesis|alkene substituted compound anabolism|alkene substituted compound anabolic process|alkene substituted compound biosynthesis https://github.com/geneontology/go-ontology/issues/19936 krc 2020-09-02T23:30:20Z biological_process owl:Class GO:1903634 biolink:NamedThing negative regulation of leucine-tRNA ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of leucine-tRNA ligase activity. tmpzr1t_l9r_go_relaxed.owl down regulation of leucyl-tRNA synthetase activity|negative regulation of leucine-tRNA synthetase activity|downregulation of L-leucine:tRNALeu ligase (AMP-forming)|down regulation of leucyl-transfer ribonucleate synthetase activity|inhibition of leucyl-transfer ribonucleic acid synthetase activity|inhibition of leucyl-transfer RNA synthetase activity|negative regulation of leucine translase activity|down regulation of leucine-tRNA ligase activity|down regulation of L-leucine:tRNALeu ligase (AMP-forming)|inhibition of leucine-tRNA ligase activity|downregulation of leucine translase activity|down-regulation of leucyl-tRNA synthetase activity|down-regulation of leucyl-transfer ribonucleate synthetase activity|negative regulation of leucyl-transfer ribonucleate synthetase activity|downregulation of leucine-tRNA synthetase activity|inhibition of leucine-tRNA synthetase activity|down-regulation of leucyl-transfer RNA synthetase activity|inhibition of leucyl-transfer ribonucleate synthetase activity|negative regulation of leucyl-transfer RNA synthetase activity|down-regulation of L-leucine:tRNALeu ligase (AMP-forming)|down regulation of leucine-tRNA synthetase activity|down-regulation of leucyl-transfer ribonucleic acid synthetase activity|downregulation of leucyl-transfer ribonucleate synthetase activity|downregulation of leucyl-tRNA synthetase activity|down-regulation of leucine translase activity|negative regulation of leucyl-tRNA synthetase activity|inhibition of L-leucine:tRNALeu ligase (AMP-forming)|down regulation of leucyl-transfer RNA synthetase activity|inhibition of leucine translase activity|down regulation of leucine translase activity|negative regulation of leucyl-transfer ribonucleic acid synthetase activity|down-regulation of leucine-tRNA synthetase activity|downregulation of leucyl-transfer RNA synthetase activity|downregulation of leucyl-transfer ribonucleic acid synthetase activity|down-regulation of leucine-tRNA ligase activity|negative regulation of L-leucine:tRNALeu ligase (AMP-forming)|inhibition of leucyl-tRNA synthetase activity|down regulation of leucyl-transfer ribonucleic acid synthetase activity|downregulation of leucine-tRNA ligase activity sl 2014-11-20T00:24:56Z biological_process owl:Class GO:1903631 biolink:NamedThing negative regulation of aminoacyl-tRNA ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of aminoacyl-tRNA ligase activity. tmpzr1t_l9r_go_relaxed.owl inhibition of aminoacyl-tRNA synthetase activity|inhibition of aminoacyl-tRNA ligase activity|down-regulation of aminoacyl-tRNA synthetase activity|inhibition of aminoacyl-tRNA synthetase auxiliary protein activity|downregulation of aminoacyl-tRNA ligase activity|negative regulation of aminoacyl-tRNA synthetase activity|negative regulation of aminoacyl-tRNA synthetase auxiliary protein activity|downregulation of aminoacyl-tRNA synthetase activity|down regulation of aminoacyl-tRNA synthetase auxiliary protein activity|down-regulation of aminoacyl-tRNA ligase activity|down-regulation of aminoacyl-tRNA synthetase auxiliary protein activity|down regulation of aminoacyl-tRNA ligase activity|downregulation of aminoacyl-tRNA synthetase auxiliary protein activity|down regulation of aminoacyl-tRNA synthetase activity sl 2014-11-20T00:22:12Z biological_process owl:Class GO:0005999 biolink:NamedThing xylulose biosynthetic process The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose. tmpzr1t_l9r_go_relaxed.owl xylulose anabolism|xylulose biosynthesis|xylulose synthesis|xylulose formation biological_process owl:Class GO:0005997 biolink:NamedThing xylulose metabolic process The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose. tmpzr1t_l9r_go_relaxed.owl xylulose metabolism biological_process owl:Class GO:2000754 biolink:NamedThing regulation of sphingomyelin catabolic process Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of sphingomyelin catabolism|regulation of sphingomyelin degradation|regulation of sphingomyelin breakdown rl 2011-06-16T03:17:30Z biological_process owl:Class GO:0035554 biolink:NamedThing termination of Roundabout signal transduction The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated. tmpzr1t_l9r_go_relaxed.owl bf 2010-05-14T11:08:12Z biological_process owl:Class GO:0023021 biolink:NamedThing termination of signal transduction The signaling process in which signal transduction is brought to an end rather than being reversibly modulated. tmpzr1t_l9r_go_relaxed.owl Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn. 2010-02-16T09:30:50Z biological_process owl:Class GO:0032657 biolink:NamedThing regulation of interleukin-14 production Any process that modulates the frequency, rate, or extent of interleukin-14 production. tmpzr1t_l9r_go_relaxed.owl regulation of interleukin-14 biosynthetic process|regulation of IL-14 production GO:0045369 biological_process owl:Class GO:0001817 biolink:NamedThing regulation of cytokine production Any process that modulates the frequency, rate, or extent of production of a cytokine. tmpzr1t_l9r_go_relaxed.owl regulation of cytokine synthesis|regulation of cytokine biosynthesis|regulation of cytokine formation|regulation of cytokine secretion|regulation of cytokine biosynthetic process|regulation of cytokine anabolism GO:0050707|GO:0042035 biological_process owl:Class GO:0048624 biolink:NamedThing plantlet formation on parent plant The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed. tmpzr1t_l9r_go_relaxed.owl vegetative vivipary|vivipary biological_process owl:Class GO:0044706 biolink:NamedThing multi-multicellular organism process A multicellular organism process which involves another multicellular organism of the same or different species. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/21459 jl 2012-09-19T16:06:16Z biological_process owl:Class GO:1904202 biolink:NamedThing negative regulation of iodide transport Any process that stops, prevents or reduces the frequency, rate or extent of iodide transport. tmpzr1t_l9r_go_relaxed.owl inhibition of iodide transport|down-regulation of iodide transport|down regulation of iodide transport|downregulation of iodide transport sl 2015-05-08T15:20:03Z biological_process owl:Class GO:2000397 biolink:NamedThing positive regulation of ubiquitin-dependent endocytosis Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis. tmpzr1t_l9r_go_relaxed.owl positive regulation of ubiquitin-mediated endocytosis mah 2011-02-22T11:25:42Z biological_process owl:Class GO:0004129 biolink:NamedThing cytochrome-c oxidase activity Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. tmpzr1t_l9r_go_relaxed.owl complex IV (mitochondrial electron transport) activity|indophenol oxidase|Warburg's respiratory enzyme activity|aa3-type cytochrome c oxidase|cytochrome oxidase activity|cytochrome aa3 activity|indophenolase|caa3-type cytochrome c oxidase|cytochrome a3 activity|cytochrome c oxidase activity|ba3-type cytochrome c oxidase|cbb3-type cytochrome c oxidase https://github.com/geneontology/go-ontology/issues/20924|https://github.com/geneontology/go-ontology/issues/21275 Reactome:R-HSA-163214|EC:7.1.1.9|MetaCyc:CYTOCHROME-C-OXIDASE-RXN|RHEA:11436 The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. molecular_function owl:Class GO:0009055 biolink:NamedThing electron transfer activity Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. tmpzr1t_l9r_go_relaxed.owl electron transporter activity|electron donor activity|electron acceptor activity|electron carrier https://github.com/geneontology/go-ontology/issues/21334 Reactome:R-HSA-169260|Reactome:R-HSA-2564826 Note that this term should only be be used for electron transfer that generates a transmembrane electrochemical gradient, e.g. components of the respiratory or photosynthetic electron transport chain. GO:0009054|GO:0009053 molecular_function owl:Class GO:0051098 biolink:NamedThing regulation of binding Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1900984 biolink:NamedThing vindoline catabolic process The chemical reactions and pathways resulting in the breakdown of vindoline. tmpzr1t_l9r_go_relaxed.owl vindoline catabolism|vindoline degradation|vindoline breakdown yaf 2012-06-14T09:16:56Z biological_process owl:Class GO:0009822 biolink:NamedThing alkaloid catabolic process The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). tmpzr1t_l9r_go_relaxed.owl alkaloid degradation|alkaloid breakdown|alkaloid catabolism biological_process owl:Class GO:0140499 biolink:NamedThing negative regulation of mitotic spindle assembly checkpoint signaling Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/19818 pg 2020-07-22T15:44:06Z biological_process owl:Class GO:0062033 biolink:NamedThing positive regulation of mitotic sister chromatid segregation Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. tmpzr1t_l9r_go_relaxed.owl dph 2018-04-23T14:32:23Z biological_process owl:Class GO:1901105 biolink:NamedThing tetracenomycin C catabolic process The chemical reactions and pathways resulting in the breakdown of tetracenomycin C. tmpzr1t_l9r_go_relaxed.owl tetracenomycin C catabolism|tetracenomycin C degradation|tetracenomycin C breakdown yaf 2012-07-11T02:50:54Z biological_process owl:Class GO:1902759 biolink:NamedThing Mo(VI)-molybdopterin cytosine dinucleotide metabolic process The chemical reactions and pathways involving Mo(VI)-molybdopterin cytosine dinucleotide. tmpzr1t_l9r_go_relaxed.owl Mo(VI)-molybdopterin cytosine dinucleotide metabolism dph 2014-03-06T14:00:31Z biological_process owl:Class GO:0009117 biolink:NamedThing nucleotide metabolic process The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). tmpzr1t_l9r_go_relaxed.owl nucleotide metabolism biological_process owl:Class GO:0000828 biolink:NamedThing inositol hexakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-1855216|Reactome:R-HSA-1855207|Reactome:R-HSA-1855227 molecular_function owl:Class GO:0016301 biolink:NamedThing kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. tmpzr1t_l9r_go_relaxed.owl phosphokinase activity Reactome:R-HSA-6788855|Reactome:R-HSA-6788867 Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. molecular_function owl:Class GO:0031978 biolink:NamedThing plastid thylakoid lumen The volume enclosed by a plastid thylakoid membrane. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0031977 biolink:NamedThing thylakoid lumen The volume enclosed by a thylakoid membrane. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:1905675 biolink:NamedThing negative regulation of adaptive immune memory response Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune memory response. tmpzr1t_l9r_go_relaxed.owl inhibition of adaptive immune memory response|down regulation of adaptive immune memory response|down-regulation of adaptive immune memory response|downregulation of adaptive immune memory response tb 2016-11-11T22:24:41Z biological_process owl:Class GO:0002820 biolink:NamedThing negative regulation of adaptive immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. tmpzr1t_l9r_go_relaxed.owl inhibition of adaptive immune response|down regulation of adaptive immune response|down-regulation of adaptive immune response|downregulation of adaptive immune response biological_process owl:Class GO:2000913 biolink:NamedThing negative regulation of galactoglucomannan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of galactoglucomannan catabolic process. tmpzr1t_l9r_go_relaxed.owl negative regulation of galactoglucomannan catabolism tt 2011-07-29T07:51:41Z biological_process owl:Class GO:0006082 biolink:NamedThing organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. tmpzr1t_l9r_go_relaxed.owl organic acid metabolism biological_process owl:Class GO:1903952 biolink:NamedThing regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. tmpzr1t_l9r_go_relaxed.owl regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization nc 2015-02-24T10:32:06Z biological_process owl:Class GO:1905031 biolink:NamedThing regulation of membrane repolarization during cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential. tmpzr1t_l9r_go_relaxed.owl rph 2016-03-07T10:24:34Z biological_process owl:Class GO:0033615 biolink:NamedThing mitochondrial proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0043461 biolink:NamedThing proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. tmpzr1t_l9r_go_relaxed.owl F-type ATPase complex assembly biological_process owl:Class GO:1902261 biolink:NamedThing positive regulation of delayed rectifier potassium channel activity Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity. tmpzr1t_l9r_go_relaxed.owl activation of delayed rectifier potassium channel activity|up regulation of delayed rectifier potassium channel activity|upregulation of delayed rectifier potassium channel activity|up-regulation of delayed rectifier potassium channel activity rl 2013-06-25T12:16:30Z biological_process owl:Class GO:1902259 biolink:NamedThing regulation of delayed rectifier potassium channel activity Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. tmpzr1t_l9r_go_relaxed.owl rl 2013-06-25T12:16:19Z biological_process owl:Class GO:0060168 biolink:NamedThing positive regulation of adenosine receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands. tmpzr1t_l9r_go_relaxed.owl positive regulation of adenosine receptor signalling pathway biological_process owl:Class GO:0045745 biolink:NamedThing positive regulation of G protein-coupled receptor signaling pathway Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity. tmpzr1t_l9r_go_relaxed.owl positive regulation of G protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signalling pathway|positive regulation of GPCR protein signalling pathway|positive regulation of G protein coupled receptor protein signalling pathway|upregulation of G-protein coupled receptor protein signaling pathway|positive regulation of GPCR protein signaling pathway|positive regulation of G-protein-coupled receptor protein signaling pathway|up-regulation of G-protein coupled receptor protein signaling pathway|up regulation of G-protein coupled receptor protein signaling pathway|stimulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein-coupled receptor protein signalling pathway|activation of G-protein coupled receptor protein signaling pathway biological_process owl:Class GO:0042104 biolink:NamedThing positive regulation of activated T cell proliferation Any process that activates or increases the rate or extent of activated T cell proliferation. tmpzr1t_l9r_go_relaxed.owl positive regulation of activated T-cell proliferation|upregulation of activated T cell proliferation|stimulation of activated T cell proliferation|positive regulation of activated T lymphocyte proliferation|positive regulation of activated T-lymphocyte proliferation|up-regulation of activated T cell proliferation|activation of activated T cell proliferation|up regulation of activated T cell proliferation biological_process owl:Class GO:0042102 biolink:NamedThing positive regulation of T cell proliferation Any process that activates or increases the rate or extent of T cell proliferation. tmpzr1t_l9r_go_relaxed.owl stimulation of T cell proliferation|up-regulation of T cell proliferation|positive regulation of T-lymphocyte proliferation|positive regulation of T lymphocyte proliferation|activation of T cell proliferation|upregulation of T cell proliferation|up regulation of T cell proliferation biological_process owl:Class GO:0080151 biolink:NamedThing positive regulation of salicylic acid mediated signaling pathway Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction. tmpzr1t_l9r_go_relaxed.owl positive regulation of salicylic acid mediated signalling pathway dhl 2010-05-20T03:10:46Z biological_process owl:Class GO:2000031 biolink:NamedThing regulation of salicylic acid mediated signaling pathway Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway. tmpzr1t_l9r_go_relaxed.owl regulation of salicylic acid mediated signalling pathway tb 2010-08-05T11:32:24Z biological_process owl:Class GO:0009242 biolink:NamedThing colanic acid biosynthetic process The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide. tmpzr1t_l9r_go_relaxed.owl colanic acid formation|colanic acid synthesis|colanic acid anabolism|M antigen biosynthesis|colanic acid biosynthesis|M antigen biosynthetic process MetaCyc:COLANSYN-PWY biological_process owl:Class GO:0046377 biolink:NamedThing colanic acid metabolic process The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues. tmpzr1t_l9r_go_relaxed.owl colanic acid metabolism biological_process owl:Class GO:0099639 biolink:NamedThing neurotransmitter receptor transport, endosome to plasma membrane The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0098877 biolink:NamedThing neurotransmitter receptor transport to plasma membrane The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0046086 biolink:NamedThing adenosine biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. tmpzr1t_l9r_go_relaxed.owl adenosine anabolism|adenosine biosynthesis|adenosine formation|adenosine synthesis biological_process owl:Class GO:0046129 biolink:NamedThing purine ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. tmpzr1t_l9r_go_relaxed.owl purine ribonucleoside formation|purine ribonucleoside synthesis|purine ribonucleoside anabolism|purine ribonucleoside biosynthesis biological_process owl:Class GO:1903250 biolink:NamedThing positive regulation of citrulline biosynthetic process Any process that activates or increases the frequency, rate or extent of citrulline biosynthetic process. tmpzr1t_l9r_go_relaxed.owl activation of citrulline synthesis|upregulation of citrulline synthesis|up-regulation of citrulline formation|activation of citrulline biosynthetic process|up-regulation of citrulline biosynthetic process|up regulation of citrulline synthesis|upregulation of citrulline biosynthetic process|positive regulation of citrulline biosynthesis|positive regulation of citrulline synthesis|activation of citrulline formation|up-regulation of citrulline synthesis|upregulation of citrulline formation|up regulation of citrulline formation|up regulation of citrulline biosynthetic process|up-regulation of citrulline anabolism|up-regulation of citrulline biosynthesis|positive regulation of citrulline formation|up regulation of citrulline anabolism|upregulation of citrulline anabolism|upregulation of citrulline biosynthesis|up regulation of citrulline biosynthesis|positive regulation of citrulline anabolism|activation of citrulline anabolism|activation of citrulline biosynthesis rl 2014-08-04T15:24:52Z biological_process owl:Class GO:0010645 biolink:NamedThing regulation of cell communication by chemical coupling Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0010646 biolink:NamedThing regulation of cell communication Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0102883 biolink:NamedThing (+)-beta-chamigrene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphoric acid. tmpzr1t_l9r_go_relaxed.owl RHEA:30379|EC:4.2.3.78|MetaCyc:RXN-8424 molecular_function owl:Class GO:0016838 biolink:NamedThing carbon-oxygen lyase activity, acting on phosphates Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. tmpzr1t_l9r_go_relaxed.owl EC:4.2.3.- molecular_function owl:Class GO:1990742 biolink:NamedThing microvesicle An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm. tmpzr1t_l9r_go_relaxed.owl ectosome|extracellular microvesicle|shedding vesicle pr 2015-05-13T13:44:52Z cellular_component owl:Class GO:1903561 biolink:NamedThing extracellular vesicle Any vesicle that is part of the extracellular region. tmpzr1t_l9r_go_relaxed.owl microparticle jl 2014-10-22T14:26:11Z cellular_component owl:Class GO:0060062 biolink:NamedThing Spemann organizer formation at the dorsal lip of the blastopore Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan. tmpzr1t_l9r_go_relaxed.owl Spemann's organizer formation at the dorsal lip of the blastopore|Spemann-Mangold organizer formation at the dorsal lip of the blastopore Occurs in amphibia, cephalochordates, cyclostomes and cartilaginous fish. biological_process owl:Class GO:0060061 biolink:NamedThing Spemann organizer formation Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan. tmpzr1t_l9r_go_relaxed.owl Spemann-Mangold organizer formation|Spemann's organizer formation biological_process owl:Class GO:1904077 biolink:NamedThing negative regulation of estrogen biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of estrogen biosynthetic process. tmpzr1t_l9r_go_relaxed.owl inhibition of estrogen synthesis|negative regulation of estrogen formation|down regulation of estrogen formation|down regulation of estrogen biosynthetic process|down-regulation of oestrogen biosynthetic process|negative regulation of oestrogen biosynthetic process|downregulation of estrogen anabolism|inhibition of estrogen anabolism|downregulation of estrogen biosynthetic process|inhibition of estrogen formation|downregulation of oestrogen biosynthetic process|down-regulation of estrogen biosynthetic process|negative regulation of estrogen synthesis|negative regulation of estrogen anabolism|inhibition of estrogen biosynthesis|down regulation of oestrogen biosynthesis|down regulation of estrogen synthesis|down regulation of oestrogen biosynthetic process|negative regulation of estrogen biosynthesis|inhibition of estrogen biosynthetic process|down-regulation of estrogen synthesis|downregulation of estrogen biosynthesis|downregulation of estrogen synthesis|inhibition of oestrogen biosynthesis|negative regulation of oestrogen biosynthesis|down-regulation of oestrogen biosynthesis|down-regulation of estrogen formation|down regulation of estrogen biosynthesis|down-regulation of estrogen biosynthesis|down regulation of estrogen anabolism|down-regulation of estrogen anabolism|downregulation of oestrogen biosynthesis|downregulation of estrogen formation|inhibition of oestrogen biosynthetic process tb 2015-03-20T16:56:20Z biological_process owl:Class GO:1904076 biolink:NamedThing regulation of estrogen biosynthetic process Any process that modulates the frequency, rate or extent of estrogen biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of estrogen synthesis|regulation of oestrogen biosynthesis|regulation of estrogen formation|regulation of oestrogen biosynthetic process|regulation of estrogen biosynthesis|regulation of estrogen anabolism tb 2015-03-20T16:56:14Z biological_process owl:Class GO:0140492 biolink:NamedThing metal-dependent deubiquitinase activity Catalysis of the metal-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin. tmpzr1t_l9r_go_relaxed.owl metal-dependent ubiquitinyl-like hydrolase activity|metal-dependent ubiquitin-like hydrolase activity https://github.com/geneontology/go-ontology/issues/17398 pg 2020-07-01T13:14:00Z molecular_function owl:Class GO:0101005 biolink:NamedThing deubiquitinase activity Catalysis of the hydrolysis of ubiquitin from proteins. tmpzr1t_l9r_go_relaxed.owl ubiquitinyl hydrolase activity https://github.com/geneontology/go-ontology/issues/17398 Reactome:R-HSA-9674127 There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases. mec 2016-02-08T09:39:38Z GO:1904265 molecular_function owl:Class GO:0031762 biolink:NamedThing follicle-stimulating hormone receptor binding Binding to a follicle-stimulating hormone receptor. tmpzr1t_l9r_go_relaxed.owl FSH receptor binding|follicle stimulating hormone receptor binding|follicle stimulating hormone receptor ligand molecular_function owl:Class GO:0010395 biolink:NamedThing rhamnogalacturonan I metabolic process The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone. tmpzr1t_l9r_go_relaxed.owl RGI metabolism|rhamnogalacturonan I metabolism biological_process owl:Class GO:0010383 biolink:NamedThing cell wall polysaccharide metabolic process The chemical reactions and pathways involving cell wall polysaccharides. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0050747 biolink:NamedThing positive regulation of lipoprotein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. tmpzr1t_l9r_go_relaxed.owl upregulation of lipoprotein metabolic process|positive regulation of lipoprotein metabolism|up regulation of lipoprotein metabolic process|up-regulation of lipoprotein metabolic process|activation of lipoprotein metabolic process|stimulation of lipoprotein metabolic process biological_process owl:Class GO:1902039 biolink:NamedThing negative regulation of seed dormancy process Any process that stops, prevents or reduces the frequency, rate or extent of seed dormancy process. tmpzr1t_l9r_go_relaxed.owl inhibition of seed dormancy process|inhibition of seed dormancy|downregulation of seed dormancy|down regulation of seed dormancy process|negative regulation of seed dormancy|down-regulation of seed dormancy process|down regulation of seed dormancy|down-regulation of seed dormancy|downregulation of seed dormancy process tb 2013-04-02T22:13:15Z biological_process owl:Class GO:1903607 biolink:NamedThing cytochrome c biosynthetic process The chemical reactions and pathways resulting in the formation of cytochrome c. tmpzr1t_l9r_go_relaxed.owl cytochrome c synthesis|cytochrome c formation|cytochrome c anabolism|cytochrome c biosynthesis dph 2014-11-13T20:01:35Z biological_process owl:Class GO:1903605 biolink:NamedThing cytochrome biosynthetic process The chemical reactions and pathways resulting in the formation of a cytochrome. tmpzr1t_l9r_go_relaxed.owl cytochrome formation|cytochrome synthesis|cytochrome biosynthesis|cytochrome anabolism dph 2014-11-13T20:01:18Z biological_process owl:Class GO:0099079 biolink:NamedThing actin body An amorphous cytoskeletal structure consisting of aggregated actin filaments and associated proteins (including fibrin and capping protein) in which there is little or no actin filament turnover. In yeast (S. pombe and S. cerevisiae) these are found only in quiescent cells and are thought to serve as a reserve store of actin. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:1905245 biolink:NamedThing regulation of aspartic-type peptidase activity Any process that modulates the frequency, rate or extent of aspartic-type peptidase activity. tmpzr1t_l9r_go_relaxed.owl jl 2016-06-09T11:55:39Z biological_process owl:Class GO:0052547 biolink:NamedThing regulation of peptidase activity Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. tmpzr1t_l9r_go_relaxed.owl peptidase regulator activity biological_process owl:Class GO:0000100 biolink:NamedThing S-methylmethionine transmembrane transporter activity Enables the transfer of S-methylmethionine from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl S-methylmethionine permease activity|S-methylmethionine transporter activity GO:0015178 molecular_function owl:Class GO:1901682 biolink:NamedThing sulfur compound transmembrane transporter activity Enables the transfer of a sulfur compound from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl sulfur molecular entity transmembrane transporter activity pr 2012-11-26T20:45:29Z molecular_function owl:Class GO:0001574 biolink:NamedThing ganglioside biosynthetic process The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. tmpzr1t_l9r_go_relaxed.owl ganglioside synthesis|ganglioside anabolism|ganglioside formation|ganglioside biosynthesis biological_process owl:Class GO:0046513 biolink:NamedThing ceramide biosynthetic process The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. tmpzr1t_l9r_go_relaxed.owl ceramide biosynthesis|ceramide synthesis|ceramide anabolism|ceramide formation biological_process owl:Class GO:0002246 biolink:NamedThing wound healing involved in inflammatory response The series of events that restore integrity to damaged tissue that contribute to an inflammatory response. tmpzr1t_l9r_go_relaxed.owl healing during inflammatory response|inflammatory response wound healing biological_process owl:Class GO:0042060 biolink:NamedThing wound healing The series of events that restore integrity to a damaged tissue, following an injury. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Wound_healing biological_process owl:Class GO:1903599 biolink:NamedThing positive regulation of autophagy of mitochondrion Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy. tmpzr1t_l9r_go_relaxed.owl upregulation of mitophagy|positive regulation of mitochondrial degradation|activation of mitochondrion degradation|up-regulation of mitophagy|up regulation of mitochondrion degradation|up regulation of mitophagy|upregulation of mitochondrion degradation|up-regulation of mitochondrion degradation|activation of mitophagy An example of this AMBRA1 - human (Q9C0C7) in PMID:21753002 inferred from direct assay pad 2014-11-10T14:25:53Z biological_process owl:Class GO:0038118 biolink:NamedThing C-C chemokine receptor CCR7 signaling pathway A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription. tmpzr1t_l9r_go_relaxed.owl CCR7 signaling pathway|C-C chemokine receptor CCR7 signalling pathway This term was created to show the binding of cytokines to multiple receptor types, and vice-versa. Known agonists of chemokine receptor type 7 (CCR7) are C-C chemokines CCL19 and CCL21. Consider instead annotating to one of the child terms 'CCL19-activated CCR7 signaling pathway ; GO:0038119' and/or 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. bf 2012-03-22T11:43:57Z biological_process owl:Class GO:0070098 biolink:NamedThing chemokine-mediated signaling pathway A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. tmpzr1t_l9r_go_relaxed.owl chemokine-mediated signalling pathway biological_process owl:Class GO:0008652 biolink:NamedThing cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. tmpzr1t_l9r_go_relaxed.owl amino acid biosynthetic process|cellular amino acid anabolism|cellular amino acid biosynthesis|cellular amino acid synthesis|cellular amino acid formation Wikipedia:Amino_acid_synthesis biological_process owl:Class GO:0046394 biolink:NamedThing carboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. tmpzr1t_l9r_go_relaxed.owl carboxylic acid synthesis|carboxylic acid formation|carboxylic acid biosynthesis|carboxylic acid anabolism biological_process owl:Class GO:0010536 biolink:NamedThing positive regulation of activation of Janus kinase activity Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. tmpzr1t_l9r_go_relaxed.owl positive regulation of tyrosine phosphorylation of JAK1 protein|positive regulation of activation of JAK protein|positive regulation of activation of JAK1 protein|positive regulation of activation of JAK1 kinase activity|positive regulation of tyrosine phosphorylation of JAK2 protein|positive regulation of activation of JAK2 kinase activity|positive regulation of tyrosine phosphorylation of JAK protein|positive regulation of activation of JAK2 protein GO:0010537|GO:0010535 biological_process owl:Class GO:0075138 biolink:NamedThing response to host oxygen tension environment Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl response of symbiont to host oxygen tension environment Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class GO:0075136 biolink:NamedThing response to host Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl response of symbiont to host Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class GO:0090339 biolink:NamedThing negative regulation of formin-nucleated actin cable assembly Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. tmpzr1t_l9r_go_relaxed.owl tb 2010-06-01T03:26:31Z biological_process owl:Class GO:1905661 biolink:NamedThing regulation of telomerase RNA reverse transcriptase activity Any process that modulates the frequency, rate or extent of telomerase RNA reverse transcriptase activity. tmpzr1t_l9r_go_relaxed.owl regulation of telomerase, catalyst nc 2016-11-09T16:55:20Z biological_process owl:Class GO:0051972 biolink:NamedThing regulation of telomerase activity Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. tmpzr1t_l9r_go_relaxed.owl telomerase regulator biological_process owl:Class GO:0043799 biolink:NamedThing glycine oxidase activity Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide. tmpzr1t_l9r_go_relaxed.owl glycine:oxygen oxidoreductase (deaminating) MetaCyc:1.4.3.19-RXN|MetaCyc:RXN-8672|EC:1.4.3.19|MetaCyc:RXN-8674|MetaCyc:RXN-8673 molecular_function owl:Class GO:0016641 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. tmpzr1t_l9r_go_relaxed.owl EC:1.4.3.- molecular_function owl:Class GO:0075015 biolink:NamedThing formation of infection structure The formation of a symbiont structure that serves to infect its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl formation of host penetration structure|formation by symbiont of infection structure on or near host|formation of infection structure on or near host|formation of host infection structure https://github.com/geneontology/go-ontology/issues/19014|https://github.com/geneontology/go-ontology/issues/20472 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. biological_process owl:Class GO:0035371 biolink:NamedThing microtubule plus-end The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. tmpzr1t_l9r_go_relaxed.owl growing microtubule plus end|microtubule plus end bf 2010-03-11T10:55:00Z cellular_component owl:Class GO:1990752 biolink:NamedThing microtubule end Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. tmpzr1t_l9r_go_relaxed.owl This term should be used when it is not possible to distinguish between the two microtubule ends, e.g. during image annotation. Whenever possible, please annotate to one of the more specific children GO:0035371 'microtubule plus-end' or GO:0036449 'microtubule minus-end'. pr 2015-05-25T12:50:31Z cellular_component owl:Class GO:1902158 biolink:NamedThing positive regulation of response to G2 DNA damage checkpoint signaling Any process that activates or increases the frequency, rate or extent of response to G2 DNA damage checkpoint signaling. tmpzr1t_l9r_go_relaxed.owl positive regulation of G2/M transition DNA damage checkpoint effector process|up-regulation of response to signal involved in G2/M transition DNA damage checkpoint|up regulation of G2/M transition DNA damage checkpoint effector process|activation of response to G2 DNA damage checkpoint signaling|up regulation of response to signal involved in G2/M transition DNA damage checkpoint|upregulation of response to G2 DNA damage checkpoint signaling|up regulation of response to G2 DNA damage checkpoint signaling|upregulation of G2/M transition DNA damage checkpoint effector process|up-regulation of G2/M transition DNA damage checkpoint effector process|upregulation of response to signal involved in G2/M transition DNA damage checkpoint|positive regulation of response to signal involved in G2/M transition DNA damage checkpoint|up-regulation of response to G2 DNA damage checkpoint signaling|activation of response to signal involved in G2/M transition DNA damage checkpoint|activation of G2/M transition DNA damage checkpoint effector process jl 2013-05-21T15:45:10Z biological_process owl:Class GO:1900833 biolink:NamedThing D-leucine biosynthetic process The chemical reactions and pathways resulting in the formation of D-leucine. tmpzr1t_l9r_go_relaxed.owl D-leucine anabolism|D-leucine biosynthesis|D-leucine formation|D-leucine synthesis se 2012-06-06T09:37:47Z biological_process owl:Class GO:0009098 biolink:NamedThing leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. tmpzr1t_l9r_go_relaxed.owl leucine formation|leucine anabolism|leucine biosynthesis|leucine synthesis MetaCyc:LEUSYN-PWY biological_process owl:Class GO:0035172 biolink:NamedThing hemocyte proliferation The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. tmpzr1t_l9r_go_relaxed.owl arthropod blood cell proliferation biological_process owl:Class GO:0090280 biolink:NamedThing positive regulation of calcium ion import Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. tmpzr1t_l9r_go_relaxed.owl positive regulation of transmembrane calcium influx tb 2010-02-08T05:11:20Z biological_process owl:Class GO:0051928 biolink:NamedThing positive regulation of calcium ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl stimulation of calcium ion transport|positive regulation of calcium transport|up regulation of calcium ion transport|upregulation of calcium ion transport|up-regulation of calcium ion transport|activation of calcium ion transport biological_process owl:Class GO:0006101 biolink:NamedThing citrate metabolic process The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle. tmpzr1t_l9r_go_relaxed.owl citrate metabolism biological_process owl:Class GO:0032939 biolink:NamedThing positive regulation of translation in response to oxidative stress Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. tmpzr1t_l9r_go_relaxed.owl upregulation of translation in response to oxidative stress|stimulation of translation in response to oxidative stress|up regulation of translation in response to oxidative stress|activation of translation in response to oxidative stress|up-regulation of translation in response to oxidative stress biological_process owl:Class GO:0032056 biolink:NamedThing positive regulation of translation in response to stress Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. tmpzr1t_l9r_go_relaxed.owl up-regulation of translation in response to stress|up regulation of translation in response to stress|activation of translation in response to stress|upregulation of translation in response to stress|stimulation of translation in response to stress biological_process owl:Class GO:1902021 biolink:NamedThing regulation of bacterial-type flagellum-dependent cell motility Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility. tmpzr1t_l9r_go_relaxed.owl regulation of bacterial-type flagellar cell motility|regulation of flagellin-based flagellar cell motility|regulation of bacterial-type flagellum cell motility jl 2013-03-27T14:42:50Z biological_process owl:Class GO:2000145 biolink:NamedThing regulation of cell motility Any process that modulates the frequency, rate or extent of cell motility. tmpzr1t_l9r_go_relaxed.owl regulation of movement of a cell|regulation of cell movement|regulation of cell locomotion mah 2010-10-01T09:41:21Z biological_process owl:Class GO:0009013 biolink:NamedThing succinate-semialdehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+. tmpzr1t_l9r_go_relaxed.owl succinate-semialdehyde:NAD(P)+ oxidoreductase activity|succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) UM-BBD_reactionID:r0371|EC:1.2.1.16|MetaCyc:SUCCSEMIALDDEHYDROG-RXN molecular_function owl:Class GO:0016620 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. tmpzr1t_l9r_go_relaxed.owl EC:1.2.1.-|Reactome:R-HSA-1222583 molecular_function owl:Class GO:0090173 biolink:NamedThing regulation of synaptonemal complex assembly Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed. tmpzr1t_l9r_go_relaxed.owl tb 2009-12-11T11:40:36Z biological_process owl:Class GO:0010564 biolink:NamedThing regulation of cell cycle process Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0044195 biolink:NamedThing nucleoplasmic reticulum Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport. tmpzr1t_l9r_go_relaxed.owl nuclear channels jl 2009-10-20T02:24:09Z cellular_component owl:Class GO:0060768 biolink:NamedThing regulation of epithelial cell proliferation involved in prostate gland development Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. tmpzr1t_l9r_go_relaxed.owl dph 2009-07-08T07:34:56Z biological_process owl:Class GO:1990186 biolink:NamedThing regulation of lymphatic vessel size Any process that modulates the size of lymphatic vessels. tmpzr1t_l9r_go_relaxed.owl regulation of collecting lymphatic vessel size sl 2013-09-11T15:41:16Z biological_process owl:Class GO:1990183 biolink:NamedThing lymphatic vascular process in circulatory system A circulatory process that occurs at the level of the lymphatic vasculature. tmpzr1t_l9r_go_relaxed.owl sl 2013-09-10T22:26:40Z biological_process owl:Class GO:0080079 biolink:NamedThing cellobiose glucosidase activity Catalysis of the reaction: cellobiose + H2O = 2 D-glucose. tmpzr1t_l9r_go_relaxed.owl cellobiose glucohydrolase activity MetaCyc:RXN-10773 dhl 2009-04-14T04:07:16Z molecular_function owl:Class GO:0008422 biolink:NamedThing beta-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. tmpzr1t_l9r_go_relaxed.owl beta-D-glucoside glucohydrolase activity|cellobiase activity|primeverosidase activity|emulsin|beta-1,6-glucosidase activity|beta-glucoside glucohydrolase activity|aryl-beta-glucosidase activity|cytokine beta-glucosidase activity|salicilinase activity|gentiobiase activity|limarase activity|amygdalase activity|gentobiase activity|arbutinase activity|amygdalinase|p-nitrophenyl beta-glucosidase activity|beta-D-glucosidase activity|elaterase activity MetaCyc:3.2.1.21-RXN|EC:3.2.1.21 GO:0016983 molecular_function owl:Class GO:0035066 biolink:NamedThing positive regulation of histone acetylation Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. tmpzr1t_l9r_go_relaxed.owl activation of histone acetylation|up-regulation of histone acetylation|upregulation of histone acetylation|stimulation of histone acetylation|up regulation of histone acetylation biological_process owl:Class GO:0045067 biolink:NamedThing positive extrathymic T cell selection The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. tmpzr1t_l9r_go_relaxed.owl positive extrathymic T-cell selection|positive extrathymic T-lymphocyte selection|positive extrathymic T lymphocyte selection biological_process owl:Class GO:0045062 biolink:NamedThing extrathymic T cell selection The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus. tmpzr1t_l9r_go_relaxed.owl extrathymic T-lymphocyte selection|extrathymic T-cell selection|extrathymic T lymphocyte selection biological_process owl:Class GO:0035809 biolink:NamedThing regulation of urine volume Any process that modulates the amount of urine excreted from the body over a unit of time. tmpzr1t_l9r_go_relaxed.owl regulation of urinary volume|regulation of urine flow bf 2011-04-20T01:17:38Z biological_process owl:Class GO:0003014 biolink:NamedThing renal system process A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). tmpzr1t_l9r_go_relaxed.owl kidney system process|excretory system process biological_process owl:Class GO:1903399 biolink:NamedThing positive regulation of m7G(5')pppN diphosphatase activity Any process that activates or increases the frequency, rate or extent of m7G(5')pppN diphosphatase activity. tmpzr1t_l9r_go_relaxed.owl activation of m7G(5')pppN pyrophosphatase activity|up regulation of m7G(5')pppN pyrophosphatase activity|upregulation of decapase activity|up regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|up-regulation of M(7)G(5')pppN pyrophosphatase activity|activation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|up-regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|upregulation of m7G(5')pppN pyrophosphatase activity|up-regulation of m7G(5')pppN pyrophosphatase activity|upregulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|activation of m7G(5')pppN diphosphatase activity|upregulation of M(7)G(5')pppN pyrophosphatase activity|upregulation of m7G(5')pppN diphosphatase activity|up-regulation of m7G(5')pppN diphosphatase activity|positive regulation of decapase activity|activation of M(7)G(5')pppN pyrophosphatase activity|positive regulation of m7G(5')pppN pyrophosphatase activity|activation of decapase activity|positive regulation of M(7)G(5')pppN pyrophosphatase activity|up regulation of M(7)G(5')pppN pyrophosphatase activity|up regulation of decapase activity|positive regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|up regulation of m7G(5')pppN diphosphatase activity|up-regulation of decapase activity mah 2014-09-01T10:16:49Z biological_process owl:Class GO:1990559 biolink:NamedThing mitochondrial coenzyme A transmembrane transport The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion. tmpzr1t_l9r_go_relaxed.owl vw 2014-11-19T12:58:26Z biological_process owl:Class GO:1990542 biolink:NamedThing mitochondrial transmembrane transport The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. tmpzr1t_l9r_go_relaxed.owl vw 2014-11-19T11:19:21Z biological_process owl:Class GO:0031942 biolink:NamedThing i-AAA complex Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0098800 biolink:NamedThing inner mitochondrial membrane protein complex Any protein complex that is part of the inner mitochondrial membrane. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0031846 biolink:NamedThing neurotensin receptor binding Binding to a neurotensin receptor. tmpzr1t_l9r_go_relaxed.owl neurotensin receptor ligand molecular_function owl:Class GO:0071855 biolink:NamedThing neuropeptide receptor binding Binding to a neuropeptide receptor. tmpzr1t_l9r_go_relaxed.owl mah 2010-09-10T03:21:43Z molecular_function owl:Class GO:0034145 biolink:NamedThing positive regulation of toll-like receptor 4 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway. tmpzr1t_l9r_go_relaxed.owl positive regulation of toll-like receptor 4 signalling pathway|positive regulation of TLR4 signaling pathway biological_process owl:Class GO:0047125 biolink:NamedThing delta1-piperideine-2-carboxylate reductase activity Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate. tmpzr1t_l9r_go_relaxed.owl delta 1-piperideine-2-carboxylate reductase activity|1,2-didehydropipecolic reductase activity|P2C reductase activity|D1-piperideine-2-carboxylate reductase activity|1,2-didehydropipecolate reductase activity|L-pipecolate:NADP+ 2-oxidoreductase activity RHEA:12524|EC:1.5.1.21|MetaCyc:RXN-8166 molecular_function owl:Class GO:0016646 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. tmpzr1t_l9r_go_relaxed.owl EC:1.5.1.- molecular_function owl:Class GO:0045460 biolink:NamedThing sterigmatocystin metabolic process The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. tmpzr1t_l9r_go_relaxed.owl sterigmatocystin metabolism biological_process owl:Class GO:0006725 biolink:NamedThing cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl aromatic hydrocarbon metabolic process|aromatic compound metabolism|aromatic hydrocarbon metabolism biological_process owl:Class GO:0000373 biolink:NamedThing Group II intron splicing The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. tmpzr1t_l9r_go_relaxed.owl mRNA splicing Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria. biological_process owl:Class GO:0000377 biolink:NamedThing RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure. tmpzr1t_l9r_go_relaxed.owl lariat RNA biosynthesis|lariat RNA formation biological_process owl:Class GO:0006769 biolink:NamedThing nicotinamide metabolic process The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms. tmpzr1t_l9r_go_relaxed.owl nicotinamide metabolism|vitamin B3 metabolism|niacin metabolism|niacin metabolic process|vitamin B3 metabolic process MetaCyc:PWY-5083 biological_process owl:Class GO:0009820 biolink:NamedThing alkaloid metabolic process The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). tmpzr1t_l9r_go_relaxed.owl alkaloid metabolism biological_process owl:Class GO:0030913 biolink:NamedThing paranodal junction assembly Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier. tmpzr1t_l9r_go_relaxed.owl paranodal axoglial junction formation|paranodal junction formation|paranodal junction biosynthesis biological_process owl:Class GO:0010927 biolink:NamedThing cellular component assembly involved in morphogenesis The cellular component assembly that is part of the initial shaping of the component during its developmental progression. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0038120 biolink:NamedThing CCL21-activated CCR7 signaling pathway A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. tmpzr1t_l9r_go_relaxed.owl CCL21-activated CCR7 signalling pathway bf 2012-03-22T11:47:24Z biological_process owl:Class GO:0038116 biolink:NamedThing chemokine (C-C motif) ligand 21 signaling pathway A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. tmpzr1t_l9r_go_relaxed.owl CCL21-mediated signaling pathway|C-C chemokine receptor type 7 signaling pathway|chemokine (C-C motif) ligand 21 signalling pathway The C-C chemokine CCL21 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. bf 2012-03-22T11:30:47Z biological_process owl:Class GO:0046121 biolink:NamedThing deoxyribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). tmpzr1t_l9r_go_relaxed.owl deoxyribonucleoside degradation|deoxyribonucleoside catabolism|deoxyribonucleoside breakdown biological_process owl:Class GO:0009120 biolink:NamedThing deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). tmpzr1t_l9r_go_relaxed.owl deoxyribonucleoside metabolism biological_process owl:Class GO:0015941 biolink:NamedThing pantothenate catabolic process The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. tmpzr1t_l9r_go_relaxed.owl vitamin B5 catabolic process|pantothenate catabolism|pantothenate breakdown|pantothenate degradation|vitamin B5 catabolism biological_process owl:Class GO:1903466 biolink:NamedThing regulation of mitotic DNA replication initiation Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. tmpzr1t_l9r_go_relaxed.owl regulation of DNA replication initiation involved in mitotic cell cycle DNA replication vw 2014-09-23T13:38:49Z biological_process owl:Class GO:1903463 biolink:NamedThing regulation of mitotic cell cycle DNA replication Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication. tmpzr1t_l9r_go_relaxed.owl regulation of DNA replication involved in S phase involved in mitotic cell cycle|regulation of DNA replication involved in S-phase involved in mitotic cell cycle|regulation of mitotic nuclear cell cycle DNA replication|regulation of DNA replication during S phase involved in mitotic cell cycle|regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle vw 2014-09-23T13:38:25Z biological_process owl:Class GO:1905876 biolink:NamedThing positive regulation of postsynaptic density organization Any process that activates or increases the frequency, rate or extent of postsynaptic density organization. tmpzr1t_l9r_go_relaxed.owl up regulation of postsynaptic density organisation|positive regulation of post synaptic density organization|activation of PSD organization|up regulation of post-synaptic density organization|activation of postsynaptic density organisation|activation of post synaptic density organization|up-regulation of postsynaptic density organisation|up-regulation of postsynaptic density organization|up regulation of post synaptic density organization|up-regulation of post-synaptic density organization|upregulation of post synaptic density organization|upregulation of postsynaptic density organization|activation of postsynaptic density organization|positive regulation of PSD organization|upregulation of PSD organization|up-regulation of PSD organization|up regulation of postsynaptic density organization|up regulation of PSD organization|activation of post-synaptic density organization|positive regulation of post-synaptic density organization|up-regulation of post synaptic density organization|upregulation of post-synaptic density organization|positive regulation of postsynaptic density organisation|upregulation of postsynaptic density organisation sl 2017-01-27T19:53:50Z biological_process owl:Class GO:0006937 biolink:NamedThing regulation of muscle contraction Any process that modulates the frequency, rate or extent of muscle contraction. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0042919 biolink:NamedThing benzoate transport The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0015849 biolink:NamedThing organic acid transport The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0047463 biolink:NamedThing 2-aminohexano-6-lactam racemase activity Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam. tmpzr1t_l9r_go_relaxed.owl alpha-amino-epsilon-caprolactam racemase activity|2-amino-hexano-6-lactam racemase activity RHEA:14813|EC:5.1.1.15|KEGG_REACTION:R04736|MetaCyc:5.1.1.15-RXN molecular_function owl:Class GO:0016855 biolink:NamedThing racemase and epimerase activity, acting on amino acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. tmpzr1t_l9r_go_relaxed.owl EC:5.1.1.- molecular_function owl:Class GO:0044731 biolink:NamedThing Ost-alpha/Ost-beta complex A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity. tmpzr1t_l9r_go_relaxed.owl (Ost)2 complex|Ost alpha-Ost beta complex|SLC51 complex jl 2012-11-06T13:42:06Z cellular_component owl:Class GO:0098797 biolink:NamedThing plasma membrane protein complex Any protein complex that is part of the plasma membrane. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:1900492 biolink:NamedThing negative regulation of [4Fe-4S] cluster assembly Any process that stops, prevents or reduces the frequency, rate or extent of [4Fe-4S] cluster assembly. tmpzr1t_l9r_go_relaxed.owl downregulation of 4Fe-4S cluster assembly|down regulation of [4Fe-4S] cluster assembly|inhibition of 4Fe-4S cluster assembly|downregulation of [4Fe-4S] cluster biosynthetic process|inhibition of [4Fe-4S] cluster biosynthetic process|down-regulation of [4Fe-4S] cluster assembly|down regulation of [4Fe-4S] cluster biosynthetic process|negative regulation of [4Fe-4S] cluster biosynthetic process|inhibition of [4Fe-4S] cluster assembly|negative regulation of 4Fe-4S cluster assembly|down-regulation of 4Fe-4S cluster assembly|down regulation of 4Fe-4S cluster assembly|down-regulation of [4Fe-4S] cluster biosynthetic process|downregulation of [4Fe-4S] cluster assembly tt 2012-05-02T03:49:00Z biological_process owl:Class GO:1903330 biolink:NamedThing negative regulation of iron-sulfur cluster assembly Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur cluster assembly. tmpzr1t_l9r_go_relaxed.owl downregulation of iron-sulfur cluster assembly|down regulation of iron-sulphur cluster assembly|inhibition of iron-sulphur cluster assembly|inhibition of iron-sulfur cluster biosynthesis|down regulation of iron-sulfur cluster assembly|down regulation of iron-sulfur cluster biosynthesis|downregulation of iron-sulphur cluster assembly|negative regulation of iron-sulfur cluster biosynthesis|down-regulation of iron-sulfur cluster biosynthesis|inhibition of iron-sulfur cluster assembly|down-regulation of iron-sulfur cluster assembly|downregulation of iron-sulfur cluster biosynthesis|down-regulation of iron-sulphur cluster assembly|negative regulation of iron-sulphur cluster assembly vw 2014-08-18T13:12:50Z biological_process owl:Class GO:0016165 biolink:NamedThing linoleate 13S-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. tmpzr1t_l9r_go_relaxed.owl lionoleate:O2 oxidoreductase activity|fat oxidase activity|lipoxygenase activity|carotene oxidase activity|linoleate:oxygen 13-oxidoreductase activity|lipoperoxidase activity|lipoxidase activity|lipoxydase activity RHEA:22780|EC:1.13.11.12|MetaCyc:LIPOXYGENASE-RXN molecular_function owl:Class GO:0019299 biolink:NamedThing rhamnose metabolic process The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. tmpzr1t_l9r_go_relaxed.owl rhamnose metabolism biological_process owl:Class GO:0019318 biolink:NamedThing hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. tmpzr1t_l9r_go_relaxed.owl hexose metabolism biological_process owl:Class GO:0005178 biolink:NamedThing integrin binding Binding to an integrin. tmpzr1t_l9r_go_relaxed.owl integrin ligand molecular_function owl:Class GO:0050839 biolink:NamedThing cell adhesion molecule binding Binding to a cell adhesion molecule. tmpzr1t_l9r_go_relaxed.owl CAM binding|cell adhesion receptor activity|cell adhesion molecule activity|adhesive extracellular matrix constituent molecular_function owl:Class GO:0090440 biolink:NamedThing abscisic acid transmembrane transporter activity Enables the transfer of abscisic acid from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl abscisic acid transporter activity tb 2012-08-20T14:29:42Z molecular_function owl:Class GO:0015665 biolink:NamedThing alcohol transmembrane transporter activity Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0010900 biolink:NamedThing negative regulation of phosphatidylcholine catabolic process Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0150174 biolink:NamedThing negative regulation of phosphatidylcholine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine metabolic process. tmpzr1t_l9r_go_relaxed.owl bc 2020-01-21T14:03:53Z biological_process owl:Class GO:2000849 biolink:NamedThing regulation of glucocorticoid secretion Any process that modulates the frequency, rate or extent of glucocorticoid secretion. tmpzr1t_l9r_go_relaxed.owl bf 2011-07-26T08:44:43Z biological_process owl:Class GO:2000846 biolink:NamedThing regulation of corticosteroid hormone secretion Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. tmpzr1t_l9r_go_relaxed.owl regulation of corticosteroid secretion bf 2011-07-26T08:43:38Z biological_process owl:Class GO:0033050 biolink:NamedThing clavulanic acid biosynthetic process The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. tmpzr1t_l9r_go_relaxed.owl clavulanic acid anabolism|clavulanic acid formation|clavulanic acid synthesis|clavulanic acid biosynthesis Wikipedia:Clavulanic_acid biological_process owl:Class GO:0050714 biolink:NamedThing positive regulation of protein secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. tmpzr1t_l9r_go_relaxed.owl up-regulation of protein secretion|up regulation of protein secretion|activation of protein secretion|upregulation of protein secretion|stimulation of protein secretion biological_process owl:Class GO:1903532 biolink:NamedThing positive regulation of secretion by cell Any process that activates or increases the frequency, rate or extent of secretion by cell. tmpzr1t_l9r_go_relaxed.owl positive regulation of cellular secretion|up-regulation of cellular secretion|up regulation of cellular secretion|activation of secretion by cell|upregulation of secretion by cell|up-regulation of secretion by cell|activation of cellular secretion|up regulation of secretion by cell|upregulation of cellular secretion pm 2014-10-08T13:25:17Z biological_process owl:Class GO:1905042 biolink:NamedThing negative regulation of epithelium regeneration Any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration. tmpzr1t_l9r_go_relaxed.owl inhibition of epithelium regeneration|down-regulation of regeneration of epithelium|downregulation of epithelium regeneration|down regulation of regeneration of epithelium|down-regulation of epithelium regeneration|down regulation of epithelium regeneration|negative regulation of regeneration of epithelium|downregulation of regeneration of epithelium|inhibition of regeneration of epithelium rph 2016-03-11T10:59:03Z biological_process owl:Class GO:1905041 biolink:NamedThing regulation of epithelium regeneration Any process that modulates the frequency, rate or extent of epithelium regeneration. tmpzr1t_l9r_go_relaxed.owl regulation of regeneration of epithelium rph 2016-03-11T10:58:53Z biological_process owl:Class GO:0016830 biolink:NamedThing carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. tmpzr1t_l9r_go_relaxed.owl other carbon-carbon lyase activity EC:4.1.-.-|Reactome:R-HSA-389611 molecular_function owl:Class GO:1900650 biolink:NamedThing negative regulation of dehydroaustinol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of dehydroaustinol biosynthetic process. tmpzr1t_l9r_go_relaxed.owl downregulation of dehydroaustinol anabolism|negative regulation of dehydroaustinol formation|down regulation of dehydroaustinol biosynthesis|down-regulation of dehydroaustinol synthesis|negative regulation of dehydroaustinol biosynthesis|down regulation of dehydroaustinol formation|inhibition of dehydroaustinol formation|down-regulation of dehydroaustinol biosynthetic process|inhibition of dehydroaustinol biosynthetic process|negative regulation of dehydroaustinol anabolism|downregulation of dehydroaustinol biosynthesis|downregulation of dehydroaustinol biosynthetic process|down-regulation of dehydroaustinol formation|down regulation of dehydroaustinol anabolism|inhibition of dehydroaustinol synthesis|downregulation of dehydroaustinol formation|down-regulation of dehydroaustinol anabolism|downregulation of dehydroaustinol synthesis|down regulation of dehydroaustinol biosynthetic process|negative regulation of dehydroaustinol synthesis|inhibition of dehydroaustinol anabolism|down-regulation of dehydroaustinol biosynthesis|inhibition of dehydroaustinol biosynthesis|down regulation of dehydroaustinol synthesis di 2012-05-22T04:06:22Z biological_process owl:Class GO:0002705 biolink:NamedThing positive regulation of leukocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. tmpzr1t_l9r_go_relaxed.owl stimulation of leukocyte mediated immunity|up-regulation of leukocyte mediated immunity|up regulation of leukocyte mediated immunity|positive regulation of immune cell mediated immunity|positive regulation of leucocyte mediated immunity|upregulation of leukocyte mediated immunity|activation of leukocyte mediated immunity biological_process owl:Class GO:0002703 biolink:NamedThing regulation of leukocyte mediated immunity Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. tmpzr1t_l9r_go_relaxed.owl regulation of immune cell mediated immunity|regulation of leucocyte mediated immunity biological_process owl:Class GO:0035776 biolink:NamedThing pronephric proximal tubule development The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. tmpzr1t_l9r_go_relaxed.owl bf 2011-04-04T11:02:54Z biological_process owl:Class GO:0039020 biolink:NamedThing pronephric nephron tubule development The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct. tmpzr1t_l9r_go_relaxed.owl bf 2010-07-02T10:11:36Z biological_process owl:Class GO:0006598 biolink:NamedThing polyamine catabolic process The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. tmpzr1t_l9r_go_relaxed.owl polyamine degradation|polyamine breakdown|polyamine catabolism biological_process owl:Class GO:0006595 biolink:NamedThing polyamine metabolic process The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. tmpzr1t_l9r_go_relaxed.owl polyamine metabolism biological_process owl:Class GO:0106114 biolink:NamedThing regulation of mitotic cohesin dsDNA (leading strand) loading Any process that modulates the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading. tmpzr1t_l9r_go_relaxed.owl hjd 2018-04-18T14:48:13Z biological_process owl:Class GO:0002722 biolink:NamedThing negative regulation of B cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production. tmpzr1t_l9r_go_relaxed.owl negative regulation of B-lymphocyte cytokine production|down regulation of B cell cytokine production|negative regulation of B-cell cytokine production|negative regulation of B lymphocyte cytokine production|down-regulation of B cell cytokine production|downregulation of B cell cytokine production|inhibition of B cell cytokine production biological_process owl:Class GO:0010116 biolink:NamedThing positive regulation of abscisic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. tmpzr1t_l9r_go_relaxed.owl activation of abscisic acid biosynthetic process|positive regulation of abscisic acid biosynthesis|up-regulation of abscisic acid biosynthetic process|positive regulation of abscisic acid formation|positive regulation of abscisic acid anabolism|positive regulation of abscisic acid synthesis|stimulation of abscisic acid biosynthetic process|upregulation of abscisic acid biosynthetic process|up regulation of abscisic acid biosynthetic process biological_process owl:Class GO:0032892 biolink:NamedThing positive regulation of organic acid transport Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl stimulation of organic acid transport|upregulation of organic acid transport|up regulation of organic acid transport|up-regulation of organic acid transport|activation of organic acid transport biological_process owl:Class GO:0032890 biolink:NamedThing regulation of organic acid transport Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1905735 biolink:NamedThing regulation of L-proline import across plasma membrane Any process that modulates the frequency, rate or extent of L-proline import across plasma membrane. tmpzr1t_l9r_go_relaxed.owl vw 2016-12-04T20:42:16Z biological_process owl:Class GO:0036152 biolink:NamedThing phosphatidylethanolamine acyl-chain remodeling Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. tmpzr1t_l9r_go_relaxed.owl bf 2012-03-14T02:09:00Z biological_process owl:Class GO:0046470 biolink:NamedThing phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. tmpzr1t_l9r_go_relaxed.owl phosphatidylcholine metabolism biological_process owl:Class GO:0035343 biolink:NamedThing negative regulation of inosine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl negative regulation of hypoxanthine riboside transport bf 2010-03-04T10:06:07Z biological_process owl:Class GO:0046346 biolink:NamedThing mannosamine catabolic process The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. tmpzr1t_l9r_go_relaxed.owl mannosamine catabolism|mannosamine breakdown|mannosamine degradation biological_process owl:Class GO:0046348 biolink:NamedThing amino sugar catabolic process The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. tmpzr1t_l9r_go_relaxed.owl amino sugar catabolism|amino sugar degradation|aminosaccharide catabolism|aminosaccharide catabolic process|amino sugar breakdown biological_process owl:Class GO:0033787 biolink:NamedThing cyanocobalamin reductase (cyanide-eliminating) activity Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP(+) = cyanocob(III)alamin + H(+) + NADPH. tmpzr1t_l9r_go_relaxed.owl cyanocobalamin reductase (NADPH; CN-eliminating) activity|cob(I)alamin, cyanide:NADP+ oxidoreductase activity|cyanocobalamin reductase (NADPH, cyanide-eliminating) activity|NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity|NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity|cyanocobalamin reductase activity EC:1.16.1.6|RHEA:16113|MetaCyc:1.6.99.12-RXN|Reactome:R-HSA-3149519|KEGG_REACTION:R02999 Formerly EC:1.6.99.12. molecular_function owl:Class GO:0016723 biolink:NamedThing oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor. tmpzr1t_l9r_go_relaxed.owl oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor|oxidoreductase activity, reducing metal ions, NAD or NADP as acceptor https://github.com/geneontology/go-ontology/issues/20675 EC:1.16.1.-|Reactome:R-HSA-917811 molecular_function owl:Class GO:0035539 biolink:NamedThing 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. tmpzr1t_l9r_go_relaxed.owl 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity|8-oxo-dGTP pyrophosphohydrolase activity|8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity|8-oxo-dGTPase activity|8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity RHEA:31575|Reactome:R-HSA-2395869|Reactome:R-HSA-2395849|EC:3.6.1.55 bf 2010-05-07T10:54:19Z molecular_function owl:Class GO:0047429 biolink:NamedThing nucleoside-triphosphate diphosphatase activity Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. tmpzr1t_l9r_go_relaxed.owl nucleoside-triphosphate pyrophosphatase activity|nucleoside-triphosphate diphosphohydrolase activity MetaCyc:3.6.1.19-RXN|EC:3.6.1.9 molecular_function owl:Class GO:0140052 biolink:NamedThing cellular response to oxidised low-density lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to oxidised LDL particle stimulus|cellular response to oxidized LDL particle stimulus|cellular response to ox-LDL particle stimulus|cellular response to oxLDL particle stimulus|cellular response to oxidized low-density lipoprotein particle stimulus pg 2017-06-26T09:40:00Z biological_process owl:Class GO:0055094 biolink:NamedThing response to lipoprotein particle Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. tmpzr1t_l9r_go_relaxed.owl response to lipoprotein particle stimulus biological_process owl:Class GO:0016799 biolink:NamedThing hydrolase activity, hydrolyzing N-glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond. tmpzr1t_l9r_go_relaxed.owl EC:3.2.2.- molecular_function owl:Class GO:0016798 biolink:NamedThing hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond. tmpzr1t_l9r_go_relaxed.owl glycosidase activity|glycosylase|N-glycosylase Reactome:R-HSA-2065233|Reactome:R-HSA-1793176|EC:3.2.-.- molecular_function owl:Class GO:0042684 biolink:NamedThing cardioblast cell fate commitment The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0060911 biolink:NamedThing cardiac cell fate commitment The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. tmpzr1t_l9r_go_relaxed.owl cardiocyte cell fate commitment dph 2009-09-17T08:47:00Z biological_process owl:Class GO:0008568 biolink:NamedThing microtubule-severing ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. tmpzr1t_l9r_go_relaxed.owl katanin activity|ATP phosphohydrolase (tubulin-dimerizing) EC:5.6.1.1|MetaCyc:3.6.4.3-RXN|Reactome:R-HSA-9668419 See also the cellular component term 'katanin complex ; GO:0008352'. molecular_function owl:Class GO:0140096 biolink:NamedThing catalytic activity, acting on a protein Catalytic activity that acts to modify a protein. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-14T10:32:59Z molecular_function owl:Class GO:0018912 biolink:NamedThing 1,4-dichlorobenzene metabolic process The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs. tmpzr1t_l9r_go_relaxed.owl 1,4-dichlorobenzene metabolism UM-BBD_pathwayID:dcz biological_process owl:Class GO:0042537 biolink:NamedThing benzene-containing compound metabolic process The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. tmpzr1t_l9r_go_relaxed.owl benzene and derivative metabolism|benzene and derivative metabolic process|benzene-containing compound metabolism biological_process owl:Class GO:0090298 biolink:NamedThing negative regulation of mitochondrial DNA replication Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion. tmpzr1t_l9r_go_relaxed.owl negative regulation of mitochondrial DNA synthesis tb 2010-03-12T03:58:25Z biological_process owl:Class GO:2000104 biolink:NamedThing negative regulation of DNA-dependent DNA replication Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. tmpzr1t_l9r_go_relaxed.owl mah 2010-09-15T01:37:05Z biological_process owl:Class GO:0098759 biolink:NamedThing cellular response to interleukin-8 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to IL-8 biological_process owl:Class GO:0071345 biolink:NamedThing cellular response to cytokine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2009-12-11T02:41:12Z biological_process owl:Class GO:0061264 biolink:NamedThing mesonephric glomerular mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell. tmpzr1t_l9r_go_relaxed.owl dph 2010-08-30T02:59:11Z biological_process owl:Class GO:0072152 biolink:NamedThing glomerular mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell. tmpzr1t_l9r_go_relaxed.owl mah 2010-02-24T02:14:58Z biological_process owl:Class GO:0071394 biolink:NamedThing cellular response to testosterone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2009-12-11T04:11:29Z biological_process owl:Class GO:0042457 biolink:NamedThing ethylene catabolic process The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. tmpzr1t_l9r_go_relaxed.owl ethylene breakdown|ethene catabolism|ethene catabolic process|ethylene degradation|ethylene catabolism biological_process owl:Class GO:0009692 biolink:NamedThing ethylene metabolic process The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. tmpzr1t_l9r_go_relaxed.owl ethene metabolic process|ethylene metabolism|ethene metabolism biological_process owl:Class GO:1902207 biolink:NamedThing positive regulation of interleukin-2-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of interleukin-2-mediated signaling pathway. tmpzr1t_l9r_go_relaxed.owl positive regulation of interleukin-2-mediated signalling pathway|upregulation of interleukin-2-mediated signaling pathway|up regulation of IL-2-mediated signaling pathway|up-regulation of interleukin-2-mediated signaling pathway|activation of IL-2-mediated signaling pathway|activation of interleukin-2-mediated signaling pathway|up regulation of interleukin-2-mediated signaling pathway|upregulation of IL-2-mediated signaling pathway|up-regulation of interleukin-2-mediated signalling pathway|activation of interleukin-2-mediated signalling pathway|upregulation of interleukin-2-mediated signalling pathway|positive regulation of IL-2-mediated signaling pathway|up regulation of interleukin-2-mediated signalling pathway|up-regulation of IL-2-mediated signaling pathway lb 2013-06-11T07:34:50Z biological_process owl:Class GO:0042846 biolink:NamedThing glycol catabolic process The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent. tmpzr1t_l9r_go_relaxed.owl glycol degradation|glycol breakdown|glycol catabolism|dihydric alcohol catabolism|dihydric alcohol catabolic process biological_process owl:Class GO:0042844 biolink:NamedThing glycol metabolic process The chemical reactions and pathways involving glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent. tmpzr1t_l9r_go_relaxed.owl dihydric alcohol metabolic process|dihydric alcohol metabolism|glycol metabolism biological_process owl:Class GO:2000553 biolink:NamedThing positive regulation of T-helper 2 cell cytokine production Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production. tmpzr1t_l9r_go_relaxed.owl positive regulation of Th2 cell cytokine production ebc 2011-04-03T07:32:58Z biological_process owl:Class GO:0002726 biolink:NamedThing positive regulation of T cell cytokine production Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. tmpzr1t_l9r_go_relaxed.owl activation of T cell cytokine production|stimulation of T cell cytokine production|positive regulation of T-cell cytokine production|up regulation of T cell cytokine production|upregulation of T cell cytokine production|positive regulation of T lymphocyte cytokine production|positive regulation of T-lymphocyte cytokine production|up-regulation of T cell cytokine production biological_process owl:Class GO:0005142 biolink:NamedThing interleukin-11 receptor binding Binding to an interleukin-11 receptor. tmpzr1t_l9r_go_relaxed.owl IL-11|interleukin-11 receptor ligand molecular_function owl:Class GO:0070851 biolink:NamedThing growth factor receptor binding Binding to a growth factor receptor. tmpzr1t_l9r_go_relaxed.owl mah 2009-08-07T11:23:02Z molecular_function owl:Class GO:0010735 biolink:NamedThing positive regulation of transcription via serum response element binding Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0045944 biolink:NamedThing positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. tmpzr1t_l9r_go_relaxed.owl stimulation of global transcription from RNA polymerase II promoter|upregulation of transcription from RNA polymerase II promoter|stimulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|up-regulation of global transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter, global|activation of transcription from RNA polymerase II promoter|up-regulation of transcription from RNA polymerase II promoter|upregulation of global transcription from RNA polymerase II promoter|up regulation of global transcription from RNA polymerase II promoter|activation of global transcription from RNA polymerase II promoter|positive regulation of gene-specific transcription from RNA polymerase II promoter|up regulation of transcription from RNA polymerase II promoter|positive regulation of global transcription from Pol II promoter|positive regulation of transcription from Pol II promoter GO:0010552|GO:0045817 biological_process owl:Class GO:0060862 biolink:NamedThing negative regulation of floral organ abscission Any process that decreases the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs. tmpzr1t_l9r_go_relaxed.owl dph 2009-08-12T04:05:23Z biological_process owl:Class GO:0018243 biolink:NamedThing protein O-linked glycosylation via threonine The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine. tmpzr1t_l9r_go_relaxed.owl protein amino acid O-linked glycosylation via threonine RESID:AA0155 biological_process owl:Class GO:0006493 biolink:NamedThing protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. tmpzr1t_l9r_go_relaxed.owl protein amino acid O-linked glycosylation RESID:AA0157|RESID:AA0212|RESID:AA0153|RESID:AA0154|RESID:AA0155 biological_process owl:Class GO:0015969 biolink:NamedThing guanosine tetraphosphate metabolic process The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. tmpzr1t_l9r_go_relaxed.owl guanosine tetraphosphate (5'-ppGpp-3') metabolism|guanosine tetraphosphate metabolism|guanosine tetraphosphate (5'-ppGpp-3') metabolic process MetaCyc:PPGPPMET-PWY biological_process owl:Class GO:0009150 biolink:NamedThing purine ribonucleotide metabolic process The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. tmpzr1t_l9r_go_relaxed.owl purine ribonucleotide metabolism biological_process owl:Class GO:1903358 biolink:NamedThing regulation of Golgi organization Any process that modulates the frequency, rate or extent of Golgi organization. tmpzr1t_l9r_go_relaxed.owl regulation of Golgi organisation|regulation of Golgi organization and biogenesis als 2014-08-21T10:22:22Z biological_process owl:Class GO:0042323 biolink:NamedThing negative regulation of circadian sleep/wake cycle, non-REM sleep Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep. tmpzr1t_l9r_go_relaxed.owl down regulation of circadian sleep/wake cycle, non-REM sleep|inhibition of circadian sleep/wake cycle, non-REM sleep|negative regulation of non-REM sleep|down-regulation of circadian sleep/wake cycle, non-REM sleep|downregulation of circadian sleep/wake cycle, non-REM sleep biological_process owl:Class GO:0036140 biolink:NamedThing peptidyl-asparagine 3-dioxygenase activity Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2. tmpzr1t_l9r_go_relaxed.owl bf 2012-03-07T09:27:44Z molecular_function owl:Class GO:1901657 biolink:NamedThing glycosyl compound metabolic process The chemical reactions and pathways involving glycosyl compound. tmpzr1t_l9r_go_relaxed.owl glycosyl compound metabolism pr 2012-11-20T14:24:07Z biological_process owl:Class GO:1901135 biolink:NamedThing carbohydrate derivative metabolic process The chemical reactions and pathways involving carbohydrate derivative. tmpzr1t_l9r_go_relaxed.owl carbohydrate derivative metabolism bf 2012-07-12T04:05:09Z biological_process owl:Class GO:0002707 biolink:NamedThing negative regulation of lymphocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. tmpzr1t_l9r_go_relaxed.owl inhibition of lymphocyte mediated immunity|downregulation of lymphocyte mediated immunity|down regulation of lymphocyte mediated immunity|down-regulation of lymphocyte mediated immunity biological_process owl:Class GO:0002704 biolink:NamedThing negative regulation of leukocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. tmpzr1t_l9r_go_relaxed.owl inhibition of leukocyte mediated immunity|negative regulation of leucocyte mediated immunity|negative regulation of immune cell mediated immunity|downregulation of leukocyte mediated immunity|down regulation of leukocyte mediated immunity|down-regulation of leukocyte mediated immunity biological_process owl:Class GO:0150070 biolink:NamedThing regulation of arginase activity Any process that modulates the frequency, rate or extent of arginase activity. tmpzr1t_l9r_go_relaxed.owl bc 2018-07-25T09:17:30Z biological_process owl:Class GO:0060906 biolink:NamedThing negative regulation of heterochromatin assembly by small RNA Any process that decreases the frequency, rate or extent of heterochromatin assembly by small RNA. tmpzr1t_l9r_go_relaxed.owl negative regulation of chromatin silencing by small RNA|negative regulation of RNAi-mediated heterochromatin assembly https://github.com/geneontology/go-ontology/issues/19112 dph 2009-08-14T01:22:24Z biological_process owl:Class GO:0010964 biolink:NamedThing regulation of heterochromatin assembly by small RNA Any process that modulates the frequency, rate or extent of heterochromatin assembly by small RNA. tmpzr1t_l9r_go_relaxed.owl regulation of RNAi-mediated heterochromatin assembly|regulation of chromatin silencing by small RNA https://github.com/geneontology/go-ontology/issues/19112 tb 2009-05-20T11:25:42Z biological_process owl:Class GO:0150077 biolink:NamedThing regulation of neuroinflammatory response Any process that modulates the frequency, rate or extent of neuroinflammatory response. tmpzr1t_l9r_go_relaxed.owl bc 2018-07-26T12:32:18Z biological_process owl:Class GO:0050727 biolink:NamedThing regulation of inflammatory response Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0048000 biolink:NamedThing isoflavone 3'-hydroxylase activity Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O. tmpzr1t_l9r_go_relaxed.owl formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)|isoflavone 3'-monooxygenase activity RHEA:22960|EC:1.14.14.88|MetaCyc:RXN-3762 molecular_function owl:Class GO:0099556 biolink:NamedThing trans-synaptic signaling by carbon monoxide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse. tmpzr1t_l9r_go_relaxed.owl Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class GO:0099554 biolink:NamedThing trans-synaptic signaling by soluble gas, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse. tmpzr1t_l9r_go_relaxed.owl Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class GO:0018798 biolink:NamedThing gallate decarboxylase activity Catalysis of the reaction: gallate + H(+) = CO(2) + pyrogallol. tmpzr1t_l9r_go_relaxed.owl gallate carboxy-lyase activity|gallic acid decarboxylase activity|gallate carboxy-lyase (pyrogallol-forming) RHEA:12749|MetaCyc:GALLATE-DECARBOXYLASE-RXN|EC:4.1.1.59|UM-BBD_reactionID:r0005|KEGG_REACTION:R03247 molecular_function owl:Class GO:0039602 biolink:NamedThing suppression by virus of host transcription initiation from RNA polymerase II promoter Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template. tmpzr1t_l9r_go_relaxed.owl inhibition of host transcription initiation by virus|suppression by virus of host DNA-dependent transcription, initiation VZ:904 bf 2012-07-05T03:29:34Z GO:0039601 biological_process owl:Class GO:0039653 biolink:NamedThing suppression by virus of host transcription Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors. tmpzr1t_l9r_go_relaxed.owl host transcription shutoff by virus|suppression by virus of host DNA-dependent transcription VZ:1577 bf 2012-10-11T16:11:17Z biological_process owl:Class GO:0099175 biolink:NamedThing regulation of postsynapse organization Any process that modulates the physical form of a postsynapse. tmpzr1t_l9r_go_relaxed.owl regulation of postsynapse structure|regulation of postsynapse organisation|regulation of postsynapse organization and biogenesis biological_process owl:Class GO:0140667 biolink:NamedThing regulation of oxytocin production Any process that modulates the frequency, rate, or extent of production of oxytocin. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/21535 pg 2021-06-24T11:28:07Z biological_process owl:Class GO:2000199 biolink:NamedThing positive regulation of ribonucleoprotein complex localization Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization. tmpzr1t_l9r_go_relaxed.owl positive regulation of establishment and maintenance of ribonucleoprotein complex localization|positive regulation of cellular ribonucleoprotein complex localization|positive regulation of ribonucleoprotein complex localisation|positive regulation of RNP localization mah 2010-10-26T10:35:55Z biological_process owl:Class GO:2000197 biolink:NamedThing regulation of ribonucleoprotein complex localization Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization. tmpzr1t_l9r_go_relaxed.owl regulation of cellular ribonucleoprotein complex localization|regulation of RNP localization|regulation of ribonucleoprotein complex localisation|regulation of establishment and maintenance of ribonucleoprotein complex localization mah 2010-10-26T10:35:48Z biological_process owl:Class GO:1900515 biolink:NamedThing regulation of xylose catabolic process to ethanol Any process that modulates the frequency, rate or extent of xylose catabolic process to ethanol. tmpzr1t_l9r_go_relaxed.owl regulation of xylose catabolism to ethanol tt 2012-05-02T04:09:07Z biological_process owl:Class GO:0043469 biolink:NamedThing regulation of D-xylose catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0046374 biolink:NamedThing teichoic acid metabolic process The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. tmpzr1t_l9r_go_relaxed.owl teichoic acid metabolism biological_process owl:Class GO:0080145 biolink:NamedThing cysteine homeostasis Any process involved in the maintenance of an internal steady state of cysteine within an organism or cell. tmpzr1t_l9r_go_relaxed.owl dhl 2010-01-27T04:49:14Z biological_process owl:Class GO:0055080 biolink:NamedThing cation homeostasis Any process involved in the maintenance of an internal steady state of cations within an organism or cell. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0021905 biolink:NamedThing forebrain-midbrain boundary formation The process whose specific outcome is the creation of the forebrain-midbrain boundary. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0003415 biolink:NamedThing chondrocyte hypertrophy The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time. tmpzr1t_l9r_go_relaxed.owl dph 2009-12-22T08:48:44Z biological_process owl:Class GO:0048588 biolink:NamedThing developmental cell growth The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. tmpzr1t_l9r_go_relaxed.owl developmental growth of a unicellular organism biological_process owl:Class GO:0062126 biolink:NamedThing fatty acid primary amide metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform primary fatty amides. tmpzr1t_l9r_go_relaxed.owl primary fatty amide metabolic process dph 2019-05-30T18:23:02Z biological_process owl:Class GO:0010684 biolink:NamedThing tricyclic triterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings. tmpzr1t_l9r_go_relaxed.owl tricyclic triterpenoid catabolism biological_process owl:Class GO:0018184 biolink:NamedThing protein polyamination The modification of a protein amino acid by polyamination. tmpzr1t_l9r_go_relaxed.owl protein amino acid polyamination biological_process owl:Class GO:0006464 biolink:NamedThing cellular protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). tmpzr1t_l9r_go_relaxed.owl protein tagging activity|process resulting in protein modification|protein modification process biological_process owl:Class GO:0032533 biolink:NamedThing regulation of follicle cell microvillus length A process that modulates the length of a microvillus on a follicle cell. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0008361 biolink:NamedThing regulation of cell size Any process that modulates the size of a cell. tmpzr1t_l9r_go_relaxed.owl cell size control biological_process owl:Class GO:0015464 biolink:NamedThing acetylcholine receptor activity Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. tmpzr1t_l9r_go_relaxed.owl For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'. molecular_function owl:Class GO:0061130 biolink:NamedThing pancreatic bud formation The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. tmpzr1t_l9r_go_relaxed.owl dph 2010-05-17T09:33:40Z biological_process owl:Class GO:0048645 biolink:NamedThing animal organ formation The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. tmpzr1t_l9r_go_relaxed.owl initiation of an animal organ primordium|animal organ primordium initiation biological_process owl:Class GO:1900452 biolink:NamedThing regulation of long-term synaptic depression Any process that modulates the frequency, rate or extent of long term synaptic depression. tmpzr1t_l9r_go_relaxed.owl regulation of LTD|regulation of long term synaptic depression|regulation of long term depression rl 2012-04-27T03:54:58Z biological_process owl:Class GO:0048167 biolink:NamedThing regulation of synaptic plasticity A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. tmpzr1t_l9r_go_relaxed.owl Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class GO:0033670 biolink:NamedThing regulation of NAD+ kinase activity Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule. tmpzr1t_l9r_go_relaxed.owl NAD kinase regulator|regulation of NAD kinase activity biological_process owl:Class GO:0060379 biolink:NamedThing cardiac muscle cell myoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. tmpzr1t_l9r_go_relaxed.owl myocardial precursor cell differentiation|cardiac myoblast differentiation biological_process owl:Class GO:0010002 biolink:NamedThing cardioblast differentiation The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. tmpzr1t_l9r_go_relaxed.owl cardioblast cell differentiation|cardiomyocyte generation|cardiac precursor cell differentiation biological_process owl:Class GO:0042339 biolink:NamedThing keratan sulfate metabolic process The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. tmpzr1t_l9r_go_relaxed.owl keratan sulfate metabolism|keratan sulphate metabolism|keratan sulphate metabolic process biological_process owl:Class GO:1903510 biolink:NamedThing mucopolysaccharide metabolic process The chemical reactions and pathways involving mucopolysaccharide. tmpzr1t_l9r_go_relaxed.owl mucopolysaccharide metabolism dph 2014-10-01T21:55:47Z biological_process owl:Class GO:0090685 biolink:NamedThing RNA localization to nucleus A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. tmpzr1t_l9r_go_relaxed.owl RNA localisation to nucleus tb 2016-07-19T17:00:49Z biological_process owl:Class GO:0006403 biolink:NamedThing RNA localization A process in which RNA is transported to, or maintained in, a specific location. tmpzr1t_l9r_go_relaxed.owl RNA localisation|establishment and maintenance of RNA localization biological_process owl:Class GO:0008119 biolink:NamedThing thiopurine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. tmpzr1t_l9r_go_relaxed.owl mercaptopurine methyltransferase activity|TPMT|6-thiopurine transmethylase activity|S-adenosyl-L-methionine:thiopurine S-methyltransferase activity|thiopurine methyltransferase activity MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN|EC:2.1.1.67|Reactome:R-HSA-158609|Reactome:R-HSA-5603379 molecular_function owl:Class GO:0061388 biolink:NamedThing regulation of rate of cell growth Any process that modulates the rate of cell growth. tmpzr1t_l9r_go_relaxed.owl dph 2011-07-14T10:18:06Z biological_process owl:Class GO:0001558 biolink:NamedThing regulation of cell growth Any process that modulates the frequency, rate, extent or direction of cell growth. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0003730 biolink:NamedThing mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule. tmpzr1t_l9r_go_relaxed.owl mRNA 3' UTR binding molecular_function owl:Class GO:0003729 biolink:NamedThing mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. tmpzr1t_l9r_go_relaxed.owl base pairing with mRNA GO:0000499 molecular_function owl:Class GO:0061076 biolink:NamedThing negative regulation of neural retina development Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. tmpzr1t_l9r_go_relaxed.owl dph 2010-03-16T12:46:11Z biological_process owl:Class GO:0061074 biolink:NamedThing regulation of neural retina development Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. tmpzr1t_l9r_go_relaxed.owl dph 2010-03-16T11:47:05Z biological_process owl:Class GO:0062123 biolink:NamedThing regulation of linear element maturation Any process that modulates the rate, frequency or extent of linear element maturation. tmpzr1t_l9r_go_relaxed.owl dph 2019-04-23T13:36:20Z biological_process owl:Class GO:0004304 biolink:NamedThing estrone sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. tmpzr1t_l9r_go_relaxed.owl 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity|3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity|3'-phosphoadenylylsulfate:oestrone sulfotransferase activity|estrogen sulphotransferase activity|estrogen sulfotransferase|oestrogen sulphotransferase activity|estrone sulphotransferase activity RHEA:15973|MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN|Reactome:R-HSA-176664|EC:2.8.2.4 molecular_function owl:Class GO:0044489 biolink:NamedThing negative regulation of voltage-gated sodium channel activity in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. tmpzr1t_l9r_go_relaxed.owl jl 2012-02-01T12:21:02Z biological_process owl:Class GO:0044362 biolink:NamedThing negative regulation of molecular function in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism. tmpzr1t_l9r_go_relaxed.owl jl 2011-10-27T02:12:49Z biological_process owl:Class GO:0061815 biolink:NamedThing deubiquitinase, acting on linear ubiquitin Catalysis of the hydrolysis of ubiquitin units from linear ubiquitin chains. tmpzr1t_l9r_go_relaxed.owl Met1 linkage specific DUB|linear ubiquitin specific deubiquitinase activity|ubiquitinyl hydrolase activity, acting on linear ubiquitin dph 2016-11-28T13:58:44Z molecular_function owl:Class GO:0102030 biolink:NamedThing dTDP-L-rhamnose synthetase activity Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+. tmpzr1t_l9r_go_relaxed.owl MetaCyc:DTDPRHAMSYNTHMULTI-RXN molecular_function owl:Class GO:0042476 biolink:NamedThing odontogenesis The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. tmpzr1t_l9r_go_relaxed.owl odontogeny|tooth morphogenesis|odontosis|tooth development|odontogenesis of calcareous or chitinous tooth Wikipedia:Odontogenesis GO:0042477 biological_process owl:Class GO:0006081 biolink:NamedThing cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl alkanal metabolism|alkanal metabolic process|aldehyde metabolism biological_process owl:Class GO:0071704 biolink:NamedThing organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. tmpzr1t_l9r_go_relaxed.owl organic molecular entity metabolism|organic molecular entity metabolic process|organic substance metabolism mah 2010-03-08T03:32:18Z biological_process owl:Class GO:0033025 biolink:NamedThing regulation of mast cell apoptotic process Any process that modulates the frequency, rate, or extent of mast cell apoptotic process. tmpzr1t_l9r_go_relaxed.owl regulation of mast cell apoptosis biological_process owl:Class GO:1902485 biolink:NamedThing L-cysteine binding Binding to L-cysteine. tmpzr1t_l9r_go_relaxed.owl bhm 2013-11-12T09:06:28Z molecular_function owl:Class GO:1900193 biolink:NamedThing regulation of oocyte maturation Any process that modulates the frequency, rate or extent of oocyte maturation. tmpzr1t_l9r_go_relaxed.owl kmv 2012-03-19T09:41:18Z biological_process owl:Class GO:2000241 biolink:NamedThing regulation of reproductive process Any process that modulates the frequency, rate or extent of reproductive process. tmpzr1t_l9r_go_relaxed.owl mah 2010-11-10T02:44:02Z biological_process owl:Class GO:0032081 biolink:NamedThing negative regulation of type II site-specific deoxyribonuclease activity Any process that stops or reduces the rate of type II restriction endodeoxyribonuclease activity. tmpzr1t_l9r_go_relaxed.owl negative regulation of type II restriction endodeoxyribonuclease activity|down regulation of type II restriction endodeoxyribonuclease activity|type II restriction enzyme inhibitor|down-regulation of type II restriction endodeoxyribonuclease activity|downregulation of type II restriction endodeoxyribonuclease activity|inhibition of type II restriction endodeoxyribonuclease activity|type II restriction endodeoxyribonuclease inhibitor biological_process owl:Class GO:0005464 biolink:NamedThing UDP-xylose transmembrane transporter activity Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-742373 molecular_function owl:Class GO:0015165 biolink:NamedThing pyrimidine nucleotide-sugar transmembrane transporter activity Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0060297 biolink:NamedThing regulation of sarcomere organization Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. tmpzr1t_l9r_go_relaxed.owl regulation of sarcomere organisation biological_process owl:Class GO:1902903 biolink:NamedThing regulation of supramolecular fiber organization Any process that modulates the frequency, rate or extent of supramolecular fiber organization. tmpzr1t_l9r_go_relaxed.owl regulation of fibril organisation HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro rl 2014-04-15T16:46:36Z biological_process owl:Class GO:0001050 biolink:NamedThing single-subunit type RNA polymerase binding Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. tmpzr1t_l9r_go_relaxed.owl T3/T7 type RNA polymerase binding|SP6-type RNA polymerase binding|T3-type RNA polymerase binding|T7-type RNA polymerase binding krc 2010-09-23T02:33:45Z molecular_function owl:Class GO:0070063 biolink:NamedThing RNA polymerase binding Binding to an RNA polymerase molecule or complex. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0048737 biolink:NamedThing imaginal disc-derived appendage development The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0048736 biolink:NamedThing appendage development The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0031638 biolink:NamedThing zymogen activation The proteolytic processing of an inactive enzyme to an active form. tmpzr1t_l9r_go_relaxed.owl zymogen activation by proteolytic cleavage biological_process owl:Class GO:0016485 biolink:NamedThing protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. tmpzr1t_l9r_go_relaxed.owl protein maturation by peptide bond cleavage|protein maturation by peptide bond hydrolysis|protein maturation by proteolysis|peptidolysis during protein maturation GO:0051605 biological_process owl:Class GO:1902929 biolink:NamedThing plasma membrane of growing cell tip Any plasma membrane part that is part of a growing cell tip. tmpzr1t_l9r_go_relaxed.owl plasma membrane part of growing cell end|plasma membrane part of growing cell tip|growing cell tip plasma membrane part mah 2014-04-22T16:02:06Z cellular_component owl:Class GO:0098590 biolink:NamedThing plasma membrane region A membrane that is a (regional) part of the plasma membrane. tmpzr1t_l9r_go_relaxed.owl region of plasma membrane Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. dos 2014-03-06T11:55:32Z cellular_component owl:Class GO:0090181 biolink:NamedThing regulation of cholesterol metabolic process Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. tmpzr1t_l9r_go_relaxed.owl tb 2009-12-18T10:33:49Z biological_process owl:Class GO:1990015 biolink:NamedThing ensheathing process A cell projection (often from glial cells such as Schwann cells) that surrounds an unmyelinated axon or cell soma. tmpzr1t_l9r_go_relaxed.owl ensheathing process of Schwann cell NIF_Subcellular:sao1376748732 pr 2012-12-19T09:42:15Z cellular_component owl:Class GO:1900155 biolink:NamedThing negative regulation of bone trabecula formation Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation. tmpzr1t_l9r_go_relaxed.owl down-regulation of skeletal trabecula formation|down-regulation of bone trabecula biogenesis|down-regulation of bone trabecula formation|down regulation of bone trabecula biogenesis|down-regulation of skeletal trabecula biogenesis|down regulation of skeletal trabecula formation|negative regulation of skeletal trabecula biogenesis|inhibition of skeletal trabecula biogenesis|down regulation of bone trabecula formation|down regulation of bone trabeculation|inhibition of skeletal trabeculation|inhibition of skeletal trabecula formation|inhibition of bone trabecula formation|negative regulation of bone trabeculation|negative regulation of bone trabecula biogenesis|inhibition of bone trabeculation|downregulation of bone trabeculation|inhibition of bone trabecula biogenesis|down regulation of skeletal trabeculation|down-regulation of bone trabeculation|downregulation of skeletal trabeculation|down-regulation of skeletal trabeculation|downregulation of bone trabecula formation|downregulation of skeletal trabecula formation|negative regulation of skeletal trabecula formation|downregulation of bone trabecula biogenesis|negative regulation of skeletal trabeculation|down regulation of skeletal trabecula biogenesis|downregulation of skeletal trabecula biogenesis vk 2012-03-07T01:47:07Z biological_process owl:Class GO:1900570 biolink:NamedThing diorcinol metabolic process The chemical reactions and pathways involving diorcinol. tmpzr1t_l9r_go_relaxed.owl diorcinol metabolism di 2012-05-15T06:35:01Z biological_process owl:Class GO:0018958 biolink:NamedThing phenol-containing compound metabolic process The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. tmpzr1t_l9r_go_relaxed.owl hydroxybenzene metabolism|carbolic acid metabolism|phenol-containing compound metabolism|carbolic acid metabolic process|hydroxybenzene metabolic process UM-BBD_pathwayID:phe Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. biological_process owl:Class GO:0019417 biolink:NamedThing sulfur oxidation The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur. tmpzr1t_l9r_go_relaxed.owl sulphur oxidation biological_process owl:Class GO:0047133 biolink:NamedThing dimethylamine dehydrogenase activity Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine. tmpzr1t_l9r_go_relaxed.owl dimethylamine:electron-transferring flavoprotein oxidoreductase activity|DMADh activity EC:1.5.8.1|UM-BBD_reactionID:r1380|RHEA:10204|MetaCyc:1.5.8.1-RXN molecular_function owl:Class GO:0046997 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin. tmpzr1t_l9r_go_relaxed.owl EC:1.5.8.- molecular_function owl:Class GO:0051767 biolink:NamedThing nitric-oxide synthase biosynthetic process The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. tmpzr1t_l9r_go_relaxed.owl nitric-oxide synthase 2 biosynthetic process|nitric-oxide synthase (type 2) biosynthetic process|nitric-oxide synthase (type II) biosynthetic process|nitric-oxide synthase-1 biosynthetic process|NOS2 biosynthesis|NO synthase biosynthesis|NOS2 synthase biosynthesis|NO synthase biosynthetic process|NOS biosynthesis|NOS biosynthetic process|NOS3 biosynthesis|nitric-oxide synthase (type II) biosynthesis|inducible nitric-oxide synthase biosynthetic process|NOS1 biosynthesis|NOS2 synthase biosynthetic process|brain nitric-oxide synthase biosynthetic process|nitric-oxide synthase-3 biosynthetic process|nitric-oxide synthase-2 biosynthetic process|nitric-oxide synthase (type 2) biosynthesis|endothelial nitric-oxide synthase biosynthetic process GO:0051768 biological_process owl:Class GO:0031416 biolink:NamedThing NatB complex A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p. tmpzr1t_l9r_go_relaxed.owl N-terminal acetyltransferase B complex cellular_component owl:Class GO:0031414 biolink:NamedThing N-terminal protein acetyltransferase complex A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. tmpzr1t_l9r_go_relaxed.owl NAT complex cellular_component owl:Class GO:0002082 biolink:NamedThing regulation of oxidative phosphorylation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. tmpzr1t_l9r_go_relaxed.owl OXPHOS biological_process owl:Class GO:1903715 biolink:NamedThing regulation of aerobic respiration Any process that modulates the frequency, rate or extent of aerobic respiration. tmpzr1t_l9r_go_relaxed.owl al 2014-12-08T00:40:37Z biological_process owl:Class GO:0050813 biolink:NamedThing epothilone metabolic process The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer. tmpzr1t_l9r_go_relaxed.owl epothilone metabolism biological_process owl:Class GO:1903041 biolink:NamedThing regulation of chondrocyte hypertrophy Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy. tmpzr1t_l9r_go_relaxed.owl mr 2014-05-20T21:23:13Z biological_process owl:Class GO:0061181 biolink:NamedThing regulation of chondrocyte development Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. tmpzr1t_l9r_go_relaxed.owl dph 2010-07-14T08:28:52Z biological_process owl:Class GO:0044221 biolink:NamedThing host cell synapse The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication. tmpzr1t_l9r_go_relaxed.owl jl 2009-11-12T03:03:59Z cellular_component owl:Class GO:0031121 biolink:NamedThing equatorial microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell. tmpzr1t_l9r_go_relaxed.owl equatorial microtubule organisation|equatorial microtubule organization and biogenesis biological_process owl:Class GO:0000226 biolink:NamedThing microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. tmpzr1t_l9r_go_relaxed.owl microtubule cytoskeleton organization and biogenesis|microtubule cytoskeleton organisation|microtubule dynamics biological_process owl:Class GO:0006837 biolink:NamedThing serotonin transport The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0006812 biolink:NamedThing cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl trivalent inorganic cation transport|di-, tri-valent inorganic cation transport GO:0006819|GO:0015674|GO:0072512 biological_process owl:Class GO:0043624 biolink:NamedThing cellular protein complex disassembly The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0032984 biolink:NamedThing protein-containing complex disassembly The disaggregation of a protein-containing macromolecular complex into its constituent components. tmpzr1t_l9r_go_relaxed.owl cellular macromolecule complex disassembly|macromolecule complex disassembly|protein complex disassembly GO:0043241|GO:0034623 biological_process owl:Class GO:1901010 biolink:NamedThing (S)-reticuline metabolic process The chemical reactions and pathways involving (S)-reticuline. tmpzr1t_l9r_go_relaxed.owl (S)-reticuline metabolism yaf 2012-06-15T10:46:22Z biological_process owl:Class GO:0046445 biolink:NamedThing benzyl isoquinoline alkaloid metabolic process The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings. tmpzr1t_l9r_go_relaxed.owl benzyl isoquinoline alkaloid metabolism biological_process owl:Class GO:0035923 biolink:NamedThing flurbiprofen binding Binding to flurbiprofen. tmpzr1t_l9r_go_relaxed.owl 2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding bf 2011-07-15T03:53:53Z molecular_function owl:Class GO:0043177 biolink:NamedThing organic acid binding Binding to an organic acid, any acidic compound containing carbon in covalent linkage. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:2000558 biolink:NamedThing positive regulation of immunoglobulin production in mucosal tissue Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue. tmpzr1t_l9r_go_relaxed.owl positive regulation of antibody production in mucosal tissue ebc 2011-04-03T07:52:17Z biological_process owl:Class GO:0002639 biolink:NamedThing positive regulation of immunoglobulin production Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. tmpzr1t_l9r_go_relaxed.owl positive regulation of immunoglobulin secretion|up regulation of immunoglobulin production|up-regulation of immunoglobulin production|activation of immunoglobulin production|positive regulation of immunoglobulin biosynthetic process|upregulation of immunoglobulin production|stimulation of immunoglobulin production GO:0051024|GO:0002642 biological_process owl:Class GO:0106129 biolink:NamedThing positive regulation of store-operated calcium entry Any process that activates or increases the frequency, rate or extent of store-operated calcium entry. tmpzr1t_l9r_go_relaxed.owl hjd 2018-05-10T19:02:40Z biological_process owl:Class GO:0018883 biolink:NamedThing caprolactam metabolic process The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation. tmpzr1t_l9r_go_relaxed.owl caprolactam metabolism UM-BBD_pathwayID:cap biological_process owl:Class GO:0060303 biolink:NamedThing regulation of nucleosome density Any process that modulates the number of nucleosomes in a given region of a chromosome. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0065008 biolink:NamedThing regulation of biological quality Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. tmpzr1t_l9r_go_relaxed.owl regulation of biological attribute|regulation of biological characteristic biological_process owl:Class GO:0098786 biolink:NamedThing biofilm matrix disassembly A process that results in the disassembly of a biofilm matrix. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0098784 biolink:NamedThing biofilm matrix organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix. tmpzr1t_l9r_go_relaxed.owl biofilm matrix organization and biogenesis biological_process owl:Class GO:1901325 biolink:NamedThing response to antimycin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2012-08-30T10:12:16Z biological_process owl:Class GO:0014070 biolink:NamedThing response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. tmpzr1t_l9r_go_relaxed.owl response to organic cyclic substance biological_process owl:Class GO:0016048 biolink:NamedThing detection of temperature stimulus The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. tmpzr1t_l9r_go_relaxed.owl detection of temperature|perception of temperature|detection of thermal stimulus biological_process owl:Class GO:0009266 biolink:NamedThing response to temperature stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. tmpzr1t_l9r_go_relaxed.owl response to thermal stimulus biological_process owl:Class GO:0035611 biolink:NamedThing protein branching point deglutamylation The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue. tmpzr1t_l9r_go_relaxed.owl bf 2010-11-18T01:11:21Z biological_process owl:Class GO:0035608 biolink:NamedThing protein deglutamylation The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation. tmpzr1t_l9r_go_relaxed.owl protein amino acid deglutamylation bf 2010-11-18T01:04:38Z biological_process owl:Class GO:1903323 biolink:NamedThing regulation of snoRNA metabolic process Any process that modulates the frequency, rate or extent of snoRNA metabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of snoRNA metabolism vw 2014-08-18T13:05:17Z biological_process owl:Class GO:0097552 biolink:NamedThing mitochondrial double-strand break repair via homologous recombination The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences. tmpzr1t_l9r_go_relaxed.owl mtDSB repair via homologous recombination Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable. pr 2014-01-22T10:09:10Z biological_process owl:Class GO:0097551 biolink:NamedThing mitochondrial double-strand break repair The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. tmpzr1t_l9r_go_relaxed.owl mtDSB repair Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable. pr 2014-01-22T10:06:54Z biological_process owl:Class GO:0090707 biolink:NamedThing establishment of plant organ orientation The process that determines the orientation of a plant organ or tissue with reference to an axis. tmpzr1t_l9r_go_relaxed.owl tb 2016-10-05T12:42:47Z biological_process owl:Class GO:0048560 biolink:NamedThing establishment of anatomical structure orientation The process that determines the orientation of an anatomical structure with reference to an axis. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0099054 biolink:NamedThing presynapse assembly The aggregation, arrangement and bonding together of a set of components to form a presynapse. tmpzr1t_l9r_go_relaxed.owl presynaptic terminal assembly|presynapse biogenesis biological_process owl:Class GO:0099172 biolink:NamedThing presynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. tmpzr1t_l9r_go_relaxed.owl presynapse development|presynapse morphogenesis|presynapse organisation|presynapse organization and biogenesis biological_process owl:Class GO:0016614 biolink:NamedThing oxidoreductase activity, acting on CH-OH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. tmpzr1t_l9r_go_relaxed.owl oxidoreductase activity, acting on the CH-OH group of donors, other acceptors Reactome:R-HSA-1500781|EC:1.1.-.- molecular_function owl:Class GO:0010864 biolink:NamedThing positive regulation of protein histidine kinase activity Any process that increases the frequency, rate or extent of protein histidine kinase activity. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0032110 biolink:NamedThing regulation of protein histidine kinase activity Any process that modulates the frequency, rate or extent of protein histidine kinase activity. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0090258 biolink:NamedThing negative regulation of mitochondrial fission Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. tmpzr1t_l9r_go_relaxed.owl negative regulation of mitochondrial division tb 2010-02-03T04:05:32Z biological_process owl:Class GO:0090140 biolink:NamedThing regulation of mitochondrial fission Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. tmpzr1t_l9r_go_relaxed.owl regulation of mitochondrial division tb 2009-12-08T02:20:48Z biological_process owl:Class GO:0043065 biolink:NamedThing positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. tmpzr1t_l9r_go_relaxed.owl up regulation of apoptosis|activation of apoptosis|pro-apoptosis|stimulation of apoptosis|positive regulation of apoptosis|upregulation of apoptosis|up-regulation of apoptosis This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. biological_process owl:Class GO:1905120 biolink:NamedThing cellular response to haloperidol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus. tmpzr1t_l9r_go_relaxed.owl Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. dw 2016-04-08T12:36:47Z biological_process owl:Class GO:0097306 biolink:NamedThing cellular response to alcohol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. tmpzr1t_l9r_go_relaxed.owl pr 2012-05-15T03:49:51Z biological_process owl:Class GO:0072250 biolink:NamedThing metanephric glomerular visceral epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. tmpzr1t_l9r_go_relaxed.owl metanephric podocyte cell fate commitment mah 2010-03-19T03:46:41Z biological_process owl:Class GO:0072149 biolink:NamedThing glomerular visceral epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. tmpzr1t_l9r_go_relaxed.owl podocyte cell fate commitment mah 2010-02-24T02:08:03Z biological_process owl:Class GO:2000023 biolink:NamedThing regulation of lateral root development Any process that modulates the frequency, rate or extent of lateral root development. tmpzr1t_l9r_go_relaxed.owl tb 2010-08-05T11:24:50Z biological_process owl:Class GO:2000069 biolink:NamedThing regulation of post-embryonic root development Any process that modulates the frequency, rate or extent of post-embryonic root development. tmpzr1t_l9r_go_relaxed.owl tb 2010-08-23T11:31:32Z biological_process owl:Class GO:0032446 biolink:NamedThing protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0070647 biolink:NamedThing protein modification by small protein conjugation or removal A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. tmpzr1t_l9r_go_relaxed.owl mah 2009-05-11T02:54:03Z biological_process owl:Class GO:0031222 biolink:NamedThing arabinan catabolic process The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues. tmpzr1t_l9r_go_relaxed.owl arabinan degradation|arabinan breakdown|arabinan catabolism biological_process owl:Class GO:0000272 biolink:NamedThing polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. tmpzr1t_l9r_go_relaxed.owl polysaccharide catabolism|polysaccharide breakdown|multicellular organismal polysaccharide catabolic process|polysaccharide degradation GO:0044244 biological_process owl:Class GO:0140159 biolink:NamedThing borate export across plasma membrane The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region. tmpzr1t_l9r_go_relaxed.owl pg 2018-02-02T10:21:37Z biological_process owl:Class GO:0140115 biolink:NamedThing export across plasma membrane The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region. tmpzr1t_l9r_go_relaxed.owl efflux pg 2017-10-24T14:38:16Z biological_process owl:Class GO:0070158 biolink:NamedThing mitochondrial seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0070127 biolink:NamedThing tRNA aminoacylation for mitochondrial protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0051279 biolink:NamedThing regulation of release of sequestered calcium ion into cytosol Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. tmpzr1t_l9r_go_relaxed.owl regulation of release of sequestered calcium ion (Ca2+)|regulation of cytoplasmic release of sequestered calcium ion (Ca2+)|regulation of release of stored calcium ion (Ca2+)|regulation of calcium mobilization|regulation of calcium ion (Ca2+) mobilization|regulation of release of stored calcium ion (Ca2+) into cytosol|regulation of cytoplasmic release of stored calcium ion (Ca2+)|regulation of release of stored calcium ion (Ca2+) into cytoplasm biological_process owl:Class GO:0051282 biolink:NamedThing regulation of sequestering of calcium ion Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. tmpzr1t_l9r_go_relaxed.owl regulation of sequestering of calcium ion (Ca2+)|regulation of sequestration of calcium ion (Ca2+)|regulation of calcium ion (Ca2+) retention|regulation of calcium ion (Ca2+) sequestering|regulation of retention of calcium ion (Ca2+)|regulation of calcium ion (Ca2+) sequestration|regulation of calcium ion (Ca2+) storage|regulation of storage of calcium ion (Ca2+) biological_process owl:Class GO:0030738 biolink:NamedThing tyramine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+). tmpzr1t_l9r_go_relaxed.owl tyramine methylpherase activity|DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)|S-adenosyl-L-methionine:tyramine N-methyltransferase activity|S-adenosyl-methionine:tyramine N-methyltransferase activity EC:2.1.1.27|MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN|RHEA:14865|KEGG_REACTION:R02384 molecular_function owl:Class GO:0008582 biolink:NamedThing regulation of synaptic assembly at neuromuscular junction Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions. tmpzr1t_l9r_go_relaxed.owl regulation of synaptic growth at neuromuscular junction biological_process owl:Class GO:0051963 biolink:NamedThing regulation of synapse assembly Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. tmpzr1t_l9r_go_relaxed.owl regulation of synaptogenesis|regulation of synapse biogenesis biological_process owl:Class GO:0005515 biolink:NamedThing protein binding Binding to a protein. tmpzr1t_l9r_go_relaxed.owl glycoprotein binding|protein amino acid binding GO:0001948|GO:0045308 molecular_function owl:Class GO:0032703 biolink:NamedThing negative regulation of interleukin-2 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. tmpzr1t_l9r_go_relaxed.owl inhibition of interleukin-2 production|down regulation of interleukin-2 production|negative regulation of interleukin-2 secretion|downregulation of interleukin-2 production|down-regulation of interleukin-2 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of IL-2 production GO:0045085|GO:1900041 biological_process owl:Class GO:0032663 biolink:NamedThing regulation of interleukin-2 production Any process that modulates the frequency, rate, or extent of interleukin-2 production. tmpzr1t_l9r_go_relaxed.owl regulation of interleukin-2 secretion|regulation of IL-2 production|regulation of interleukin-2 biosynthetic process GO:1900040|GO:0045076 biological_process owl:Class GO:1900886 biolink:NamedThing positive regulation of tridecane biosynthetic process Any process that activates or increases the frequency, rate or extent of tridecane biosynthetic process. tmpzr1t_l9r_go_relaxed.owl up regulation of tridecane anabolism|positive regulation of tridecane formation|activation of tridecane biosynthesis|activation of tridecane anabolism|positive regulation of tridecane synthesis|positive regulation of tridecane biosynthesis|up regulation of tridecane formation|upregulation of tridecane anabolism|up-regulation of tridecane biosynthesis|positive regulation of tridecane anabolism|up regulation of tridecane biosynthetic process|activation of tridecane formation|up-regulation of tridecane biosynthetic process|up-regulation of tridecane anabolism|up-regulation of tridecane formation|up regulation of tridecane biosynthesis|up-regulation of tridecane synthesis|upregulation of tridecane formation|up regulation of tridecane synthesis|upregulation of tridecane biosynthetic process|upregulation of tridecane synthesis|upregulation of tridecane biosynthesis|activation of tridecane biosynthetic process|activation of tridecane synthesis tt 2012-06-13T03:01:01Z biological_process owl:Class GO:0070961 biolink:NamedThing positive regulation of neutrophil mediated killing of symbiont cell Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil. tmpzr1t_l9r_go_relaxed.owl up-regulation of neutrophil mediated killing of symbiont cell|up regulation of neutrophil mediated killing of symbiont cell|upregulation of neutrophil mediated killing of symbiont cell|activation of neutrophil mediated killing of symbiont cell|stimulation of neutrophil mediated killing of symbiont cell mah 2009-10-01T02:28:49Z biological_process owl:Class GO:0031157 biolink:NamedThing regulation of aggregate size involved in sorocarp development Any process that modulates the size of the aggregate formed during sorocarp formation. tmpzr1t_l9r_go_relaxed.owl regulation of aggregation during fruiting body formation|regulation of aggregation during fruiting body biosynthesis biological_process owl:Class GO:0019827 biolink:NamedThing stem cell population maintenance The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types. tmpzr1t_l9r_go_relaxed.owl maintenance of pluripotency biological_process owl:Class GO:0044627 biolink:NamedThing modulation of complement activation, classical pathway in other organism A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism. tmpzr1t_l9r_go_relaxed.owl regulation of complement activation, classical pathway in other organism jl 2012-07-05T12:55:53Z biological_process owl:Class GO:0030450 biolink:NamedThing regulation of complement activation, classical pathway Any process that modulates the frequency, rate or extent of the classical pathway of complement activation. tmpzr1t_l9r_go_relaxed.owl regulation of complement cascade, classical pathway biological_process owl:Class GO:1902823 biolink:NamedThing negative regulation of late endosome to lysosome transport Any process that stops, prevents or reduces the frequency, rate or extent of late endosome to lysosome transport. tmpzr1t_l9r_go_relaxed.owl downregulation of late endosome to lysosome transport|down-regulation of late endosome to lysosome transport|down regulation of late endosome to lysosome transport|inhibition of late endosome to lysosome transport pad 2014-03-31T10:08:51Z biological_process owl:Class GO:1903336 biolink:NamedThing negative regulation of vacuolar transport Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. tmpzr1t_l9r_go_relaxed.owl down regulation of vacuolar transport|downregulation of vacuolar transport|inhibition of vacuolar transport|down-regulation of vacuolar transport vw 2014-08-18T13:16:11Z biological_process owl:Class GO:1903966 biolink:NamedThing monounsaturated fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid. tmpzr1t_l9r_go_relaxed.owl monounsaturated fatty acid synthesis|monounsaturated fatty acid biosynthesis|monounsaturated fatty acid anabolism|monounsaturated fatty acid formation For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast. pr 2015-02-25T20:36:07Z biological_process owl:Class GO:0008610 biolink:NamedThing lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. tmpzr1t_l9r_go_relaxed.owl lipid anabolism|lipogenesis|lipid synthesis|lipid formation|lipid biosynthesis biological_process owl:Class GO:1905102 biolink:NamedThing positive regulation of apoptosome assembly Any process that activates or increases the frequency, rate or extent of apoptosome assembly. tmpzr1t_l9r_go_relaxed.owl up regulation of apoptosome assembly|activation of apoptosome assembly|activation of apoptosome formation|up regulation of apoptosome formation|up-regulation of apoptosome assembly|up-regulation of apoptosome formation|positive regulation of apoptosome formation|upregulation of apoptosome formation|upregulation of apoptosome assembly bc 2016-04-04T08:57:59Z biological_process owl:Class GO:0031334 biolink:NamedThing positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly. tmpzr1t_l9r_go_relaxed.owl activation of protein complex assembly|up regulation of protein complex assembly|stimulation of protein complex assembly|up-regulation of protein complex assembly|upregulation of protein complex assembly|positive regulation of protein complex assembly biological_process owl:Class GO:1900289 biolink:NamedThing negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process. tmpzr1t_l9r_go_relaxed.owl downregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|inhibition of coenzyme F420-dependent nitroimidazole breakdown|down regulation of coenzyme F420-dependent nitroimidazole catabolism|downregulation of coenzyme F420-dependent nitroimidazole reduction|down-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|down-regulation of coenzyme F420-dependent nitroimidazole reduction|downregulation of coenzyme F420-dependent nitroreductase activity|negative regulation of coenzyme F420-dependent nitroimidazole reduction|inhibition of coenzyme F420-dependent nitroimidazole reduction|down regulation of coenzyme F420-dependent nitroreductase activity|downregulation of coenzyme F420-dependent nitroimidazole catabolism|inhibition of coenzyme F420-dependent nitroreductase activity|downregulation of coenzyme F420-dependent nitroimidazole breakdown|inhibition of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|down-regulation of coenzyme F420-dependent nitroimidazole breakdown|down regulation of coenzyme F420-dependent nitroimidazole breakdown|down regulation of coenzyme F420-dependent nitroimidazole reduction|negative regulation of coenzyme F420-dependent nitroreductase activity|down-regulation of coenzyme F420-dependent nitroreductase activity|down-regulation of coenzyme F420-dependent nitroimidazole catabolism|down regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|negative regulation of coenzyme F420-dependent nitroimidazole catabolism|negative regulation of coenzyme F420-dependent nitroimidazole breakdown|inhibition of coenzyme F420-dependent nitroimidazole catabolism tt 2012-04-05T06:02:51Z biological_process owl:Class GO:1900288 biolink:NamedThing regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process Any process that modulates the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of coenzyme F420-dependent nitroimidazole reduction|regulation of coenzyme F420-dependent nitroimidazole breakdown|regulation of coenzyme F420-dependent nitroreductase activity|regulation of coenzyme F420-dependent nitroimidazole catabolism tt 2012-04-05T06:02:41Z biological_process owl:Class GO:0102425 biolink:NamedThing myricetin 3-O-glucosyltransferase activity Catalysis of the reaction: myricetin + UDP-alpha-D-glucose <=> myricetin 3-O-beta-D-glucopyranoside + UDP. tmpzr1t_l9r_go_relaxed.owl EC:2.4.1.91|MetaCyc:RXN-13822 molecular_function owl:Class GO:1904964 biolink:NamedThing positive regulation of phytol biosynthetic process Any process that activates or increases the frequency, rate or extent of phytol biosynthetic process. tmpzr1t_l9r_go_relaxed.owl upregulation of phytol anabolism|positive regulation of phytol anabolism|up regulation of phytol biosynthesis|up-regulation of phytol biosynthesis|up-regulation of phytol formation|upregulation of phytol biosynthetic process|positive regulation of phytol synthesis|activation of phytol biosynthesis|up-regulation of phytol anabolism|activation of phytol anabolism|up regulation of phytol anabolism|positive regulation of phytol biosynthesis|up regulation of phytol synthesis|activation of phytol synthesis|upregulation of phytol synthesis|up regulation of phytol formation|upregulation of phytol biosynthesis|activation of phytol biosynthetic process|up-regulation of phytol biosynthetic process|upregulation of phytol formation|positive regulation of phytol formation|up-regulation of phytol synthesis|up regulation of phytol biosynthetic process|activation of phytol formation tb 2016-02-11T00:42:07Z biological_process owl:Class GO:1904963 biolink:NamedThing regulation of phytol biosynthetic process Any process that modulates the frequency, rate or extent of phytol biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of phytol synthesis|regulation of phytol formation|regulation of phytol biosynthesis|regulation of phytol anabolism tb 2016-02-11T00:41:51Z biological_process owl:Class GO:2000655 biolink:NamedThing negative regulation of cellular response to testosterone stimulus Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus. tmpzr1t_l9r_go_relaxed.owl vk 2011-05-02T03:23:59Z biological_process owl:Class GO:0048585 biolink:NamedThing negative regulation of response to stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. tmpzr1t_l9r_go_relaxed.owl downregulation of response to stimulus|down-regulation of response to stimulus|inhibition of response to stimulus|down regulation of response to stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:0071412 biolink:NamedThing cellular response to genistein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2009-12-14T03:10:04Z biological_process owl:Class GO:0033595 biolink:NamedThing response to genistein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0070305 biolink:NamedThing response to cGMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus. tmpzr1t_l9r_go_relaxed.owl response to 3',5' cGMP|response to guanosine 3',5'-cyclophosphate|response to 3',5'-cGMP|response to cyclic GMP biological_process owl:Class GO:1903788 biolink:NamedThing positive regulation of glutathione biosynthetic process Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process. tmpzr1t_l9r_go_relaxed.owl activation of glutathione formation|upregulation of glutathione biosynthetic process|upregulation of glutathione anabolism|up regulation of glutathione anabolism|up-regulation of glutathione biosynthetic process|up-regulation of glutathione anabolism|upregulation of glutathione formation|up regulation of glutathione biosynthesis|up regulation of glutathione synthesis|activation of glutathione biosynthetic process|positive regulation of glutathione biosynthesis|up-regulation of glutathione formation|up regulation of glutathione formation|positive regulation of glutathione synthesis|up-regulation of glutathione biosynthesis|positive regulation of glutathione anabolism|up regulation of glutathione biosynthetic process|upregulation of glutathione synthesis|activation of glutathione anabolism|positive regulation of glutathione formation|activation of glutathione synthesis|activation of glutathione biosynthesis|upregulation of glutathione biosynthesis|up-regulation of glutathione synthesis bf 2015-01-08T17:15:07Z biological_process owl:Class GO:2000792 biolink:NamedThing positive regulation of mesenchymal cell proliferation involved in lung development Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. tmpzr1t_l9r_go_relaxed.owl pr 2011-06-24T01:53:56Z biological_process owl:Class GO:2000790 biolink:NamedThing regulation of mesenchymal cell proliferation involved in lung development Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. tmpzr1t_l9r_go_relaxed.owl pr 2011-06-24T01:53:50Z biological_process owl:Class GO:0001227 biolink:NamedThing DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. tmpzr1t_l9r_go_relaxed.owl transcriptional repressor activity, metal ion regulated sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding|proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific|RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding|metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription|sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding https://github.com/geneontology/go-ontology/issues/20253|https://github.com/geneontology/go-ontology/issues/16152|https://github.com/geneontology/go-ontology/issues/16131|https://github.com/geneontology/go-ontology/issues/16534 For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. krc 2010-10-26T03:56:48Z GO:0001210|GO:0001078|GO:0001206|GO:0001214 molecular_function owl:Class GO:0140110 biolink:NamedThing transcription regulator activity A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/13588 pg 2017-10-18T07:05:44Z molecular_function owl:Class GO:0071138 biolink:NamedThing alpha5-beta5-fibronectin-SFRP2 complex A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2. tmpzr1t_l9r_go_relaxed.owl ITGA5-ITGB5-FN-1-SFRP2 complex mah 2009-11-13T02:30:31Z cellular_component owl:Class GO:1901071 biolink:NamedThing glucosamine-containing compound metabolic process The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines). tmpzr1t_l9r_go_relaxed.owl glucosamine-containing compound metabolism|glucosamines metabolic process|glucosamines metabolism bf 2012-07-02T03:18:04Z biological_process owl:Class GO:0006040 biolink:NamedThing amino sugar metabolic process The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. tmpzr1t_l9r_go_relaxed.owl amino sugar metabolism|aminosaccharide metabolic process|aminosaccharide metabolism biological_process owl:Class GO:1990820 biolink:NamedThing response to mitotic DNA integrity checkpoint signaling A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling. tmpzr1t_l9r_go_relaxed.owl response to signal involved in mitotic DNA integrity checkpoint mah 2015-08-14T10:25:46Z biological_process owl:Class GO:0072414 biolink:NamedThing response to mitotic cell cycle checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling. tmpzr1t_l9r_go_relaxed.owl response to mitotic cell cycle G1/S checkpoint signaling|response to signal involved in mitotic cell cycle G1/S checkpoint|mitotic G2/M transition checkpoint effector process|response to mitotic G2/M transition checkpoint signal|response to signal involved in mitotic G2/M transition checkpoint|response to signal involved in mitotic cell cycle checkpoint|mitotic cell cycle checkpoint effector process|mitotic cell cycle G1/S checkpoint effector process mah 2010-12-08T03:50:43Z GO:0072473|GO:0072455 biological_process owl:Class GO:0009071 biolink:NamedThing serine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. tmpzr1t_l9r_go_relaxed.owl serine family amino acid breakdown|serine family amino acid degradation|serine family amino acid catabolism biological_process owl:Class GO:1901606 biolink:NamedThing alpha-amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. tmpzr1t_l9r_go_relaxed.owl alpha-amino acid catabolism|alpha-amino acid breakdown|alpha-amino acid degradation tb 2012-11-08T17:39:54Z biological_process owl:Class GO:0103078 biolink:NamedThing quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXNQT-4162|RHEA:61184 molecular_function owl:Class GO:0110109 biolink:NamedThing negative regulation of imaginal disc-derived wing vein specification Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived wing vein specification. tmpzr1t_l9r_go_relaxed.owl kmv 2018-07-05T13:55:37Z biological_process owl:Class GO:0035451 biolink:NamedThing extrinsic component of stromal side of plastid thylakoid membrane The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region. tmpzr1t_l9r_go_relaxed.owl extrinsic to stromal leaflet of plastid thylakoid membrane|peripheral to stromal side of plastid thylakoid membrane|extrinsic to stromal side of plastid thylakoid membrane bf 2010-04-16T10:18:01Z cellular_component owl:Class GO:0045145 biolink:NamedThing single-stranded DNA 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. tmpzr1t_l9r_go_relaxed.owl ssDNA-specific 5'-3' exodeoxyribonuclease activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity molecular_function owl:Class GO:0008297 biolink:NamedThing single-stranded DNA exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. tmpzr1t_l9r_go_relaxed.owl single-stranded DNA specific exodeoxyribonuclease activity|ssDNA-specific exodeoxyribonuclease activity molecular_function owl:Class GO:1900612 biolink:NamedThing F-9775B metabolic process The chemical reactions and pathways involving F-9775B. tmpzr1t_l9r_go_relaxed.owl F-9775B metabolism di 2012-05-15T07:03:01Z biological_process owl:Class GO:0030638 biolink:NamedThing polyketide metabolic process The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. tmpzr1t_l9r_go_relaxed.owl polyketide metabolism biological_process owl:Class GO:0032770 biolink:NamedThing positive regulation of monooxygenase activity Any process that activates or increases the activity of a monooxygenase. tmpzr1t_l9r_go_relaxed.owl up-regulation of monooxygenase activity|activation of monooxygenase activity|stimulation of monooxygenase activity|up regulation of monooxygenase activity|upregulation of monooxygenase activity biological_process owl:Class GO:0032768 biolink:NamedThing regulation of monooxygenase activity Any process that modulates the activity of a monooxygenase. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0003169 biolink:NamedThing coronary vein morphogenesis The process in which the anatomical structures of veins of the heart are generated and organized. tmpzr1t_l9r_go_relaxed.owl dph 2009-10-08T10:45:41Z biological_process owl:Class GO:0048845 biolink:NamedThing venous blood vessel morphogenesis The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. tmpzr1t_l9r_go_relaxed.owl venous morphogenesis|vein morphogenesis biological_process owl:Class GO:0009800 biolink:NamedThing cinnamic acid biosynthetic process The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid. tmpzr1t_l9r_go_relaxed.owl phenylpropenoic acid biosynthetic process|phenylpropenoic acid biosynthesis|cinnamic acid synthesis|phenylacrylic acid biosynthesis|cinnamylic acid biosynthesis|cinnamic acid biosynthesis|phenylacrylic acid biosynthetic process|cinnamic acid anabolism|cinnamylic acid biosynthetic process|cinnamic acid formation biological_process owl:Class GO:0009803 biolink:NamedThing cinnamic acid metabolic process The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid. tmpzr1t_l9r_go_relaxed.owl phenylpropenoic acid metabolic process|cinnamylic acid metabolism|cinnamic acid metabolism|phenylacrylic acid metabolism|phenylpropenoic acid metabolism|phenylacrylic acid metabolic process|cinnamylic acid metabolic process biological_process owl:Class GO:0060069 biolink:NamedThing Wnt signaling pathway, regulating spindle positioning The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle. tmpzr1t_l9r_go_relaxed.owl Wnt-activated signaling pathway, regulating spindle positioning|Wnt receptor signalling pathway, regulating spindle positioning|non-canonical Wnt signaling pathway|Wnt receptor signaling pathway, regulating spindle positioning biological_process owl:Class GO:0097728 biolink:NamedThing 9+0 motile cilium A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). tmpzr1t_l9r_go_relaxed.owl nodal cilium|motile 9+0 cilium This type of cilia may be present in solitary (classic nodal cilia in embryonic nodes) or in multiple copies (e.g. in the choroid plexus epithelium). pr 2016-09-27T15:24:37Z cellular_component owl:Class GO:0031514 biolink:NamedThing motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. tmpzr1t_l9r_go_relaxed.owl motile cilia|microtubule-based flagellum|motile primary cilium|motile primary cilia|motile secondary cilium|nodal cilium GO:0009434|GO:0031512 cellular_component owl:Class GO:0003849 biolink:NamedThing 3-deoxy-7-phosphoheptulonate synthase activity Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. tmpzr1t_l9r_go_relaxed.owl 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity|7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity|DHAP synthase activity|DAHP synthase activity|phospho-2-keto-3-deoxyheptonate aldolase activity|phospho-2-keto-3-deoxyheptanoate aldolase activity|DS-Mn activity|2-dehydro-3-deoxyphosphoheptonate aldolase activity|deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity|2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity|KDPH synthetase activity|7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate|phospho-2-dehydro-3-deoxyheptonate aldolase activity|7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity|D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity|phospho-2-keto-3-deoxyheptonic aldolase activity|phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)|2-dehydro-3-deoxy-phosphoheptonate aldolase activity|3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity|KDPH synthase activity|DAH7-P synthase activity|3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity|D-erythrose-4-phosphate-lyase activity|DS-Co activity|phospho-2-oxo-3-deoxyheptonate aldolase activity KEGG_REACTION:R01826|EC:2.5.1.54|MetaCyc:DAHPSYN-RXN|RHEA:14717 Note that this function was formerly EC:4.1.2.15. molecular_function owl:Class GO:0016765 biolink:NamedThing transferase activity, transferring alkyl or aryl (other than methyl) groups Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). tmpzr1t_l9r_go_relaxed.owl transferase activity, transferring alkyl or aryl groups, other than methyl groups EC:2.5.1.-|Reactome:R-HSA-4419978|Reactome:R-HSA-4755545|Reactome:R-HSA-6782893 GO:0016766 molecular_function owl:Class GO:0000019 biolink:NamedThing regulation of mitotic recombination Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. tmpzr1t_l9r_go_relaxed.owl regulation of recombination within rDNA repeats biological_process owl:Class GO:0060384 biolink:NamedThing innervation The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0051726 biolink:NamedThing regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle. tmpzr1t_l9r_go_relaxed.owl regulation of progression through cell cycle|mitotic cell cycle arrest|arrest of mitotic cell cycle progression|tumor suppressor|cell cycle arrest|negative regulation of cell cycle arrest|cell cycle regulation|cell cycle regulator|cell cycle modulation|positive regulation of cell cycle arrest|control of cell cycle progression|regulation of cell cycle progression|modulation of cell cycle progression|regulation of cell cycle arrest GO:0071157|GO:0071156|GO:0071158|GO:0071850|GO:0007050|GO:0000074 biological_process owl:Class GO:0099145 biolink:NamedThing regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane. tmpzr1t_l9r_go_relaxed.owl dos 2017-06-09T18:49:26Z biological_process owl:Class GO:0051223 biolink:NamedThing regulation of protein transport Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0016087 biolink:NamedThing ecdysiostatic hormone activity The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0005184 biolink:NamedThing neuropeptide hormone activity The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. tmpzr1t_l9r_go_relaxed.owl neurohormone Wikipedia:Neurohormone molecular_function owl:Class GO:1901794 biolink:NamedThing 3-(3-hydroxyphenyl)propanoate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxyphenyl)propanoate. tmpzr1t_l9r_go_relaxed.owl 3-(3-hydroxyphenyl)propanoate degradation|3-(3-hydroxyphenyl)propanoate breakdown|3-(3-hydroxyphenyl)propanoate catabolism yaf 2013-01-16T11:47:17Z biological_process owl:Class GO:1904859 biolink:NamedThing positive regulation of endothelial cell chemotaxis to vascular endothelial growth factor Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor. tmpzr1t_l9r_go_relaxed.owl upregulation of endothelial cell chemotaxis to vascular endothelial growth factor|activation of endothelial cell chemotaxis to vascular endothelial growth factor|up regulation of endothelial cell chemotaxis to vascular endothelial growth factor|up-regulation of endothelial cell chemotaxis to vascular endothelial growth factor rph 2015-12-16T11:48:00Z biological_process owl:Class GO:0050921 biolink:NamedThing positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. tmpzr1t_l9r_go_relaxed.owl activation of chemotaxis|up regulation of chemotaxis|up-regulation of chemotaxis|upregulation of chemotaxis|stimulation of chemotaxis biological_process owl:Class GO:0051263 biolink:NamedThing microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain. tmpzr1t_l9r_go_relaxed.owl microcin E492 anabolism by siderophore ester modification of peptidyl-serine|microcin E492 synthesis by siderophore ester modification of peptidyl-serine|microcin E492 formation by siderophore ester modification of peptidyl-serine RESID:AA0374 biological_process owl:Class GO:0018350 biolink:NamedThing protein esterification The addition of an ester group to a protein amino acid. tmpzr1t_l9r_go_relaxed.owl protein amino acid esterification biological_process owl:Class GO:0046947 biolink:NamedThing hydroxylysine biosynthetic process The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. tmpzr1t_l9r_go_relaxed.owl hydroxylysine biosynthesis|hydroxylysine anabolism|hydroxylysine synthesis|hydroxylysine formation biological_process owl:Class GO:0046946 biolink:NamedThing hydroxylysine metabolic process The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases. tmpzr1t_l9r_go_relaxed.owl hydroxylysine metabolism biological_process owl:Class GO:0008730 biolink:NamedThing L(+)-tartrate dehydratase activity Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate. tmpzr1t_l9r_go_relaxed.owl tartaric acid dehydrase activity|L-(+)-tartaric acid dehydratase activity|tartrate dehydratase activity|L-tartrate dehydratase activity|(R,R)-tartrate hydro-lyase (oxaloacetate-forming)|(R,R)-tartrate hydro-lyase activity KEGG_REACTION:R00339|RHEA:15413|EC:4.2.1.32|MetaCyc:LTARTDEHYDRA-RXN molecular_function owl:Class GO:1903923 biolink:NamedThing positive regulation of protein processing in phagocytic vesicle Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle. tmpzr1t_l9r_go_relaxed.owl up regulation of protein processing in phagocytic vesicle|up regulation of protein processing in phagosome|up-regulation of peptidolysis during protein maturation in phagosome|activation of protein maturation by peptide bond cleavage in phagocytic vesicle|upregulation of peptidolysis during protein maturation in phagocytic vesicle|up regulation of protein maturation by peptide bond cleavage in phagosome|activation of protein maturation by proteolysis in phagosome|up-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|upregulation of protein maturation by proteolysis in phagosome|upregulation of protein maturation by peptide bond hydrolysis in phagosome|positive regulation of protein maturation by peptide bond cleavage in phagosome|positive regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|activation of protein maturation by proteolysis in phagocytic vesicle|up-regulation of protein maturation by proteolysis in phagosome|activation of protein processing in phagocytic vesicle|positive regulation of protein processing in phagosome|activation of peptidolysis during protein maturation in phagosome|upregulation of protein processing in phagosome|up regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|activation of protein processing in phagosome|up-regulation of protein maturation by proteolysis in phagocytic vesicle|positive regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|upregulation of protein maturation by peptide bond cleavage in phagosome|up-regulation of protein processing in phagosome|up-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|upregulation of peptidolysis during protein maturation in phagosome|upregulation of protein maturation by proteolysis in phagocytic vesicle|activation of peptidolysis during protein maturation in phagocytic vesicle|upregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|up regulation of protein maturation by proteolysis in phagocytic vesicle|positive regulation of protein maturation by proteolysis in phagocytic vesicle|up-regulation of peptidolysis during protein maturation in phagocytic vesicle|upregulation of protein maturation by peptide bond cleavage in phagocytic vesicle|up regulation of protein maturation by peptide bond hydrolysis in phagosome|up-regulation of protein maturation by peptide bond hydrolysis in phagosome|up-regulation of protein maturation by peptide bond cleavage in phagosome|activation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|positive regulation of protein maturation by peptide bond hydrolysis in phagosome|positive regulation of peptidolysis during protein maturation in phagosome|upregulation of protein processing in phagocytic vesicle|positive regulation of peptidolysis during protein maturation in phagocytic vesicle|up regulation of protein maturation by proteolysis in phagosome|activation of protein maturation by peptide bond cleavage in phagosome|up regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|up-regulation of protein processing in phagocytic vesicle|activation of protein maturation by peptide bond hydrolysis in phagosome|positive regulation of protein maturation by proteolysis in phagosome|up regulation of peptidolysis during protein maturation in phagocytic vesicle|up regulation of peptidolysis during protein maturation in phagosome als 2015-02-10T11:17:14Z biological_process owl:Class GO:0046398 biolink:NamedThing UDP-glucuronate metabolic process The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. tmpzr1t_l9r_go_relaxed.owl UDP-glucuronate metabolism biological_process owl:Class GO:2000565 biolink:NamedThing negative regulation of CD8-positive, alpha-beta T cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. tmpzr1t_l9r_go_relaxed.owl ebc 2011-04-03T09:03:19Z biological_process owl:Class GO:2001186 biolink:NamedThing negative regulation of CD8-positive, alpha-beta T cell activation Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. tmpzr1t_l9r_go_relaxed.owl yaf 2011-11-03T01:16:57Z biological_process owl:Class GO:0015108 biolink:NamedThing chloride transmembrane transporter activity Enables the transfer of chloride ions from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl chloride ABC transporter|chloride transporting ATPase activity|chloride-transporting ATPase activity|ATPase-coupled chloride transmembrane transporter activity|ATP-dependent chloride transmembrane transporter activity|chloride ion transmembrane transporter activity RHEA:29823|Reactome:R-HSA-5678863|Reactome:R-HSA-5678992|Reactome:R-HSA-5678822|MetaCyc:3.6.3.11-RXN GO:0008555 molecular_function owl:Class GO:0043225 biolink:NamedThing ATPase-coupled inorganic anion transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in). tmpzr1t_l9r_go_relaxed.owl ATP-dependent anion transmembrane transporter activity|anion ABC transporter|anion transmembrane-transporting ATPase activity|anion-transporting ATPase activity|ATPase-coupled anion transmembrane transporter activity Reactome:R-HSA-5690340|Reactome:R-HSA-1454916 molecular_function owl:Class GO:0051581 biolink:NamedThing negative regulation of neurotransmitter uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. tmpzr1t_l9r_go_relaxed.owl down regulation of neurotransmitter uptake|negative regulation of neurotransmitter import|downregulation of neurotransmitter uptake|down-regulation of neurotransmitter uptake biological_process owl:Class GO:1900656 biolink:NamedThing negative regulation of diorcinol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of diorcinol biosynthetic process. tmpzr1t_l9r_go_relaxed.owl down-regulation of diorcinol biosynthesis|inhibition of diorcinol synthesis|down regulation of diorcinol anabolism|down-regulation of diorcinol formation|negative regulation of diorcinol synthesis|down-regulation of diorcinol synthesis|down regulation of diorcinol synthesis|down-regulation of diorcinol biosynthetic process|negative regulation of diorcinol anabolism|down-regulation of diorcinol anabolism|inhibition of diorcinol biosynthesis|downregulation of diorcinol synthesis|downregulation of diorcinol formation|downregulation of diorcinol biosynthetic process|down regulation of diorcinol formation|inhibition of diorcinol formation|down regulation of diorcinol biosynthetic process|downregulation of diorcinol anabolism|downregulation of diorcinol biosynthesis|inhibition of diorcinol biosynthetic process|negative regulation of diorcinol formation|negative regulation of diorcinol biosynthesis|inhibition of diorcinol anabolism|down regulation of diorcinol biosynthesis di 2012-05-22T04:09:01Z biological_process owl:Class GO:0031327 biolink:NamedThing negative regulation of cellular biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl down-regulation of cellular biosynthetic process|inhibition of cellular biosynthetic process|downregulation of cellular biosynthetic process|negative regulation of cellular anabolism|down regulation of cellular biosynthetic process|negative regulation of cellular formation|negative regulation of cellular biosynthesis|negative regulation of cellular synthesis biological_process owl:Class GO:1904984 biolink:NamedThing regulation of quinolinate biosynthetic process Any process that modulates the frequency, rate or extent of quinolinate biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of quinolinate formation|regulation of quinolinate anabolism|regulation of quinolinate synthesis|regulation of quinolinate biosynthesis bf 2016-02-29T15:54:12Z biological_process owl:Class GO:0007556 biolink:NamedThing regulation of juvenile hormone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. tmpzr1t_l9r_go_relaxed.owl regulation of juvenile hormone metabolism biological_process owl:Class GO:0090453 biolink:NamedThing aspartate transmembrane import into vacuole The directed movement of aspartate into the vacuole across the vacuolar membrane. tmpzr1t_l9r_go_relaxed.owl vacuolar aspartate import tb 2012-09-24T14:12:46Z biological_process owl:Class GO:0034487 biolink:NamedThing vacuolar amino acid transmembrane transport The process in which an amino acid is transported from one side of the vacuolar membrane to the other. tmpzr1t_l9r_go_relaxed.owl vacuolar amino acid membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. biological_process owl:Class GO:0098554 biolink:NamedThing cytoplasmic side of endoplasmic reticulum membrane The side (leaflet) of the plasma membrane that faces the cytoplasm. tmpzr1t_l9r_go_relaxed.owl dos 2013-12-03T12:09:47Z cellular_component owl:Class GO:0098562 biolink:NamedThing cytoplasmic side of membrane The side of a membrane that faces the cytoplasm. tmpzr1t_l9r_go_relaxed.owl dos 2013-12-12T11:21:30Z cellular_component owl:Class GO:1900727 biolink:NamedThing osmoregulated periplasmic glucan biosynthetic process The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan. tmpzr1t_l9r_go_relaxed.owl osmoregulated periplasmic glucan anabolism|osmoregulated periplasmic glucan formation|osmoregulated periplasmic glucan biosynthesis|osmoregulated periplasmic glucan synthesis jl 2012-05-24T03:19:02Z biological_process owl:Class GO:0009250 biolink:NamedThing glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. tmpzr1t_l9r_go_relaxed.owl glucan synthesis|glucan formation|glucan biosynthesis|glucan anabolism biological_process owl:Class GO:1901461 biolink:NamedThing negative regulation of response to formic acid Any process that stops, prevents or reduces the frequency, rate or extent of response to formic acid. tmpzr1t_l9r_go_relaxed.owl downregulation of response to formic acid|down regulation of response to formic acid|inhibition of response to formic acid|down-regulation of response to formic acid tt 2012-10-02T14:29:02Z biological_process owl:Class GO:1901460 biolink:NamedThing regulation of response to formic acid Any process that modulates the frequency, rate or extent of response to formic acid. tmpzr1t_l9r_go_relaxed.owl tt 2012-10-02T14:27:54Z biological_process owl:Class GO:0015742 biolink:NamedThing alpha-ketoglutarate transport The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl 2-oxoglutarate transport|mitochondrial alpha-ketoglutarate/malate transport biological_process owl:Class GO:0005847 biolink:NamedThing mRNA cleavage and polyadenylation specificity factor complex A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. tmpzr1t_l9r_go_relaxed.owl CPF complex|CPSF complex|CFII complex|cleavage and polyadenylylation specificity factor activity cellular_component owl:Class GO:0005849 biolink:NamedThing mRNA cleavage factor complex Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0035540 biolink:NamedThing positive regulation of SNARE complex disassembly Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. tmpzr1t_l9r_go_relaxed.owl bf 2010-05-10T01:42:21Z biological_process owl:Class GO:0002600 biolink:NamedThing positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. tmpzr1t_l9r_go_relaxed.owl up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib|stimulation of antigen processing and presentation of lipid antigen via MHC class Ib|upregulation of antigen processing and presentation of lipid antigen via MHC class Ib|positive regulation of lipid antigen processing and presentation via MHC class Ib|activation of antigen processing and presentation of lipid antigen via MHC class Ib|up regulation of antigen processing and presentation of lipid antigen via MHC class Ib biological_process owl:Class GO:0002598 biolink:NamedThing regulation of antigen processing and presentation of lipid antigen via MHC class Ib Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. tmpzr1t_l9r_go_relaxed.owl regulation of lipid antigen processing and presentation via MHC class Ib biological_process owl:Class GO:0035976 biolink:NamedThing transcription factor AP-1 complex A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes. tmpzr1t_l9r_go_relaxed.owl AP1 complex|AP-1 complex|transcription factor AP1 complex|Activating protein 1 complex bf 2011-08-17T10:57:51Z cellular_component owl:Class GO:0090575 biolink:NamedThing RNA polymerase II transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. tmpzr1t_l9r_go_relaxed.owl RNA polymerase II transcription factor complex tb 2014-05-09T14:04:37Z cellular_component owl:Class GO:1904810 biolink:NamedThing negative regulation of dense core granule transport Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport. tmpzr1t_l9r_go_relaxed.owl downregulation of dense core granule transport|downregulation of dense core vesicle transport|down regulation of dense core vesicle transport|down regulation of dense core granule transport|inhibition of dense core vesicle transport|down-regulation of dense core granule transport|negative regulation of dense core vesicle transport|inhibition of dense core granule transport|down-regulation of dense core vesicle transport cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). es 2015-11-11T10:40:18Z biological_process owl:Class GO:1904809 biolink:NamedThing regulation of dense core granule transport Any process that modulates the frequency, rate or extent of dense core granule transport. tmpzr1t_l9r_go_relaxed.owl regulation of dense core vesicle transport cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). es 2015-11-11T10:40:10Z biological_process owl:Class GO:0038089 biolink:NamedThing positive regulation of cell migration by vascular endothelial growth factor signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another. tmpzr1t_l9r_go_relaxed.owl VEGF-induced cell migration|VEGF-A-induced cell migration|positive regulation of cell migration by VEGF signaling pathway|positive regulation of cell migration by vascular endothelial growth factor signalling pathway bf 2012-02-02T03:40:13Z biological_process owl:Class GO:0038084 biolink:NamedThing vascular endothelial growth factor signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. tmpzr1t_l9r_go_relaxed.owl VEGF-activated signaling pathway|vascular endothelial growth factor signalling pathway|VEGF signaling In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'. bf 2012-02-01T02:27:32Z biological_process owl:Class GO:2000521 biolink:NamedThing negative regulation of immunological synapse formation Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation. tmpzr1t_l9r_go_relaxed.owl negative regulation of formation of immunological synapse ebc 2011-03-23T10:18:19Z biological_process owl:Class GO:0051250 biolink:NamedThing negative regulation of lymphocyte activation Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. tmpzr1t_l9r_go_relaxed.owl downregulation of lymphocyte activation|down regulation of lymphocyte activation|down-regulation of lymphocyte activation|inhibition of lymphocyte activation biological_process owl:Class GO:0051001 biolink:NamedThing negative regulation of nitric-oxide synthase activity Any process that stops or reduces the activity of the enzyme nitric-oxide synthase. tmpzr1t_l9r_go_relaxed.owl inhibition of nitric-oxide synthase activity|nitric-oxide synthase inhibitor|negative regulation of NOS activity|NOS inhibitor|down-regulation of nitric-oxide synthase activity|downregulation of nitric-oxide synthase activity|down regulation of nitric-oxide synthase activity biological_process owl:Class GO:0048550 biolink:NamedThing negative regulation of pinocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. tmpzr1t_l9r_go_relaxed.owl down-regulation of pinocytosis|inhibition of pinocytosis|down regulation of pinocytosis|downregulation of pinocytosis biological_process owl:Class GO:0048548 biolink:NamedThing regulation of pinocytosis Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0015871 biolink:NamedThing choline transport The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0015695 biolink:NamedThing organic cation transport The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1901772 biolink:NamedThing lincomycin metabolic process The chemical reactions and pathways involving lincomycin. tmpzr1t_l9r_go_relaxed.owl lincomycin metabolism yaf 2013-01-15T11:53:52Z biological_process owl:Class GO:0046483 biolink:NamedThing heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). tmpzr1t_l9r_go_relaxed.owl heterocycle metabolism biological_process owl:Class GO:0006076 biolink:NamedThing (1->3)-beta-D-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of (1->3)-beta-D-glucans. tmpzr1t_l9r_go_relaxed.owl 1,3-beta-D-glucan catabolic process|1,3-beta-glucan degradation|beta-1,3 glucan catabolic process|beta-1,3 glucan degradation|1,3-beta-glucan breakdown|beta-1,3 glucan breakdown|beta-1,3 glucan catabolism|1,3-beta-glucan catabolism biological_process owl:Class GO:0051275 biolink:NamedThing beta-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of beta-glucans. tmpzr1t_l9r_go_relaxed.owl beta-glucan degradation|beta-glucan catabolism|beta-glucan breakdown biological_process owl:Class GO:0060883 biolink:NamedThing regulation of basement membrane disassembly involved in semicircular canal fusion by cell communication Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basement membrane disassembly involved in semicircular canal fusion. tmpzr1t_l9r_go_relaxed.owl regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication dph 2009-08-13T11:31:56Z biological_process owl:Class GO:0110011 biolink:NamedThing regulation of basement membrane organization Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. tmpzr1t_l9r_go_relaxed.owl kmv biological_process owl:Class GO:0003363 biolink:NamedThing lamellipodium assembly involved in ameboidal cell migration Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell. tmpzr1t_l9r_go_relaxed.owl dph 2009-12-08T04:38:04Z biological_process owl:Class GO:0030032 biolink:NamedThing lamellipodium assembly Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. tmpzr1t_l9r_go_relaxed.owl lamellipodium biogenesis|lamellipodium biosynthesis|lamellipodium formation biological_process owl:Class GO:0009436 biolink:NamedThing glyoxylate catabolic process The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH. tmpzr1t_l9r_go_relaxed.owl glyoxylate degradation|glyoxylate breakdown|glyoxylate catabolism MetaCyc:GLYOXDEG-PWY biological_process owl:Class GO:0046185 biolink:NamedThing aldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. tmpzr1t_l9r_go_relaxed.owl aldehyde breakdown|aldehyde catabolism|aldehyde degradation biological_process owl:Class GO:0097063 biolink:NamedThing cadmium ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++). tmpzr1t_l9r_go_relaxed.owl pr 2011-06-08T09:46:14Z molecular_function owl:Class GO:0140299 biolink:NamedThing small molecule sensor activity Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule. tmpzr1t_l9r_go_relaxed.owl small molecular sensor activity pg 2018-12-10T14:30:28Z molecular_function owl:Class GO:0009609 biolink:NamedThing response to symbiotic bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism. tmpzr1t_l9r_go_relaxed.owl response to symbiotic bacteria biological_process owl:Class GO:0009608 biolink:NamedThing response to symbiont Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl response of host to symbiont biological_process owl:Class GO:0033026 biolink:NamedThing negative regulation of mast cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process. tmpzr1t_l9r_go_relaxed.owl down regulation of mast cell apoptosis|inhibition of mast cell apoptosis|downregulation of mast cell apoptosis|down-regulation of mast cell apoptosis|negative regulation of mast cell apoptosis biological_process owl:Class GO:0002683 biolink:NamedThing negative regulation of immune system process Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. tmpzr1t_l9r_go_relaxed.owl downregulation of immune system process|down regulation of immune system process|inhibition of immune system process|down-regulation of immune system process biological_process owl:Class GO:0018490 biolink:NamedThing 4-hydroxyphenylpyruvate oxidase activity Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O(2) = 2 (4-hydroxyphenyl)acetate + 2 CO(2). tmpzr1t_l9r_go_relaxed.owl 4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating) RHEA:17197|UM-BBD_reactionID:r0299|MetaCyc:1.2.3.13-RXN|KEGG_REACTION:R00042|EC:1.2.3.13 molecular_function owl:Class GO:0002660 biolink:NamedThing positive regulation of peripheral tolerance induction Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction. tmpzr1t_l9r_go_relaxed.owl up-regulation of peripheral tolerance induction|upregulation of peripheral tolerance induction|up regulation of peripheral tolerance induction|stimulation of peripheral tolerance induction|activation of peripheral tolerance induction biological_process owl:Class GO:0002654 biolink:NamedThing positive regulation of tolerance induction dependent upon immune response Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response. tmpzr1t_l9r_go_relaxed.owl up regulation of tolerance induction dependent upon immune response|activation of tolerance induction dependent upon immune response|upregulation of tolerance induction dependent upon immune response|positive regulation of immune response-dependent tolerance induction|up-regulation of tolerance induction dependent upon immune response|stimulation of tolerance induction dependent upon immune response biological_process owl:Class GO:0031644 biolink:NamedThing regulation of nervous system process Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. tmpzr1t_l9r_go_relaxed.owl regulation of neurological system process|regulation of neurological process|regulation of neurophysiological process biological_process owl:Class GO:0044057 biolink:NamedThing regulation of system process Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1902700 biolink:NamedThing pentose catabolic process to butan-1-ol The chemical reactions and pathways resulting in the breakdown of pentose to butan-1-ol. tmpzr1t_l9r_go_relaxed.owl pentose degradation to butan-1-ol|pentose catabolic process to butanol|pentose breakdown to butan-1-ol|pentose catabolic process to 1-butanol|pentose catabolism to butan-1-ol|solventogenesis tb 2014-02-19T18:28:47Z GO:1990290 biological_process owl:Class GO:0071270 biolink:NamedThing 1-butanol metabolic process The chemical reactions and pathways involving 1-butanol, an alkyl primary alcohol with the formula C4H10O. tmpzr1t_l9r_go_relaxed.owl 1-butanol metabolism|butanol metabolic process|butan-1-ol metabolic process mah 2009-12-10T10:23:11Z biological_process owl:Class GO:0019819 biolink:NamedThing P1 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms. tmpzr1t_l9r_go_relaxed.owl peroxisome vesicle Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. cellular_component owl:Class GO:0005777 biolink:NamedThing peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. tmpzr1t_l9r_go_relaxed.owl peroxisomal|peroxisome vesicle Wikipedia:Peroxisome|NIF_Subcellular:sao499555322 GO:0019818 cellular_component owl:Class GO:0018309 biolink:NamedThing protein-FMN linkage The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN). tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0034767 biolink:NamedThing positive regulation of ion transmembrane transport Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl stimulation of transmembrane ion transport|upregulation of transmembrane ion transport|activation of transmembrane ion transport|up-regulation of transmembrane ion transport|up regulation of transmembrane ion transport|positive regulation of ion membrane transport|positive regulation of transmembrane ion transport biological_process owl:Class GO:0043270 biolink:NamedThing positive regulation of ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl stimulation of ion transport|up-regulation of ion transport|up regulation of ion transport|activation of ion transport|upregulation of ion transport biological_process owl:Class GO:1900835 biolink:NamedThing negative regulation of emericellin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of emericellin biosynthetic process. tmpzr1t_l9r_go_relaxed.owl down-regulation of emericellin biosynthetic process|downregulation of emericellin biosynthetic process|down regulation of emericellin biosynthetic process di 2012-06-07T09:32:24Z biological_process owl:Class GO:1900377 biolink:NamedThing negative regulation of secondary metabolite biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. tmpzr1t_l9r_go_relaxed.owl down-regulation of secondary metabolite biosynthetic process|negative regulation of secondary metabolite biosynthesis|inhibition of secondary metabolite biosynthetic process|down regulation of secondary metabolite biosynthetic process|downregulation of secondary metabolite biosynthesis|downregulation of secondary metabolite biosynthetic process|down-regulation of secondary metabolite biosynthesis|inhibition of secondary metabolite biosynthesis|down regulation of secondary metabolite biosynthesis di 2012-04-17T01:55:32Z biological_process owl:Class GO:0070949 biolink:NamedThing regulation of neutrophil mediated killing of symbiont cell Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil. tmpzr1t_l9r_go_relaxed.owl mah 2009-10-01T02:14:36Z biological_process owl:Class GO:0002831 biolink:NamedThing regulation of response to biotic stimulus Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. tmpzr1t_l9r_go_relaxed.owl Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class GO:1904480 biolink:NamedThing positive regulation of intestinal absorption Any process that activates or increases the frequency, rate or extent of intestinal absorption. tmpzr1t_l9r_go_relaxed.owl activation of intestinal absorption|upregulation of intestinal absorption|up regulation of intestinal absorption|up-regulation of intestinal absorption rl 2015-07-13T15:59:00Z biological_process owl:Class GO:0060456 biolink:NamedThing positive regulation of digestive system process Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0045666 biolink:NamedThing positive regulation of neuron differentiation Any process that activates or increases the frequency, rate or extent of neuron differentiation. tmpzr1t_l9r_go_relaxed.owl stimulation of neuron differentiation|up regulation of neuron differentiation|activation of neuron differentiation|upregulation of neuron differentiation|up-regulation of neuron differentiation biological_process owl:Class GO:0003674 biolink:NamedThing molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. tmpzr1t_l9r_go_relaxed.owl molecular function Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. GO:0005554 molecular_function owl:Class GO:1900512 biolink:NamedThing regulation of starch utilization system complex assembly Any process that modulates the frequency, rate or extent of starch utilization system complex assembly. tmpzr1t_l9r_go_relaxed.owl regulation of SUS complex assembly|regulation of assembly of starch utilization system complex tt 2012-05-02T04:06:44Z biological_process owl:Class GO:0043254 biolink:NamedThing regulation of protein-containing complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. tmpzr1t_l9r_go_relaxed.owl regulation of protein complex assembly biological_process owl:Class GO:0102434 biolink:NamedThing pterin-4alpha-carbinolamine dehydratase activity Catalysis of the reaction: a 10-formyltetrahydrofolate-4a-carbinolamine = H2O + a 10-formyldihydrofolate. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-13908 molecular_function owl:Class GO:0061099 biolink:NamedThing negative regulation of protein tyrosine kinase activity Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. tmpzr1t_l9r_go_relaxed.owl dph 2010-04-26T02:34:53Z biological_process owl:Class GO:0000414 biolink:NamedThing regulation of histone H3-K36 methylation Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0051792 biolink:NamedThing medium-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of any fatty acid with a chain length of between C6 and C12. tmpzr1t_l9r_go_relaxed.owl medium chain fatty acid biosynthesis|medium chain fatty acid biosynthetic process|medium-chain fatty acid biosynthesis|medium-chain fatty acid formation|medium-chain fatty acid anabolism|medium-chain fatty acid synthesis biological_process owl:Class GO:0006633 biolink:NamedThing fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. tmpzr1t_l9r_go_relaxed.owl fatty acid anabolism|fatty acid formation|fatty acid biosynthesis|fatty acid synthesis MetaCyc:PWY-4381|Wikipedia:Fatty_acid_synthesis|MetaCyc:PWY-5156|MetaCyc:FASYN-INITIAL-PWY GO:0000037 biological_process owl:Class GO:1904664 biolink:NamedThing negative regulation of N-terminal peptidyl-methionine acetylation Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation. tmpzr1t_l9r_go_relaxed.owl vw 2015-09-07T19:18:56Z biological_process owl:Class GO:0034642 biolink:NamedThing mitochondrion migration along actin filament The directed movement of a mitochondrion along a microfilament, mediated by motor proteins. tmpzr1t_l9r_go_relaxed.owl mitochondrial migration, actin-mediated|mitochondrial migration along microfilament|mitochondrion migration along microfilament|mitochondrion transport along actin filament|mitochondrial migration along actin filament biological_process owl:Class GO:0099515 biolink:NamedThing actin filament-based transport The transport of organelles or other particles from one location in the cell to another along actin filaments. tmpzr1t_l9r_go_relaxed.owl tb 2009-05-27T10:56:08Z biological_process owl:Class GO:0062038 biolink:NamedThing positive regulation of pheromone response MAPK cascade Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade. tmpzr1t_l9r_go_relaxed.owl dph 2018-05-01T13:00:56Z biological_process owl:Class GO:1904413 biolink:NamedThing negative regulation of cardiac ventricle development Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. tmpzr1t_l9r_go_relaxed.owl downregulation of cardiac ventricle development|inhibition of cardiac ventricle development|down regulation of cardiac ventricle development|down-regulation of cardiac ventricle development sl 2015-06-25T19:52:21Z biological_process owl:Class GO:0031279 biolink:NamedThing regulation of cyclase activity Any process that modulates the frequency, rate or extent of cyclase activity. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0022870 biolink:NamedThing protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. tmpzr1t_l9r_go_relaxed.owl mannose PTS transporter activity molecular_function owl:Class GO:0015578 biolink:NamedThing mannose transmembrane transporter activity Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. tmpzr1t_l9r_go_relaxed.owl mannose permease activity GO:0015589 molecular_function owl:Class GO:0044217 biolink:NamedThing other organism part Any constituent part of a secondary organism with which the first organism is interacting. tmpzr1t_l9r_go_relaxed.owl Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. jl 2009-11-12T01:18:21Z cellular_component owl:Class GO:0019990 biolink:NamedThing pteridine catabolic process The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. tmpzr1t_l9r_go_relaxed.owl pteridine breakdown|pteridine degradation|pteridine catabolism biological_process owl:Class GO:0042560 biolink:NamedThing pteridine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. tmpzr1t_l9r_go_relaxed.owl pteridine and derivative catabolic process|pterin catabolic process|pteridine-containing compound degradation|pteridine-containing compound catabolism|pterin catabolism|pteridine and derivative catabolism|pteridine-containing compound breakdown biological_process owl:Class GO:0001097 biolink:NamedThing TFIIH-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. tmpzr1t_l9r_go_relaxed.owl TFIIH-class transcription factor binding krc 2010-10-28T02:51:41Z molecular_function owl:Class GO:0001091 biolink:NamedThing RNA polymerase II general transcription initiation factor binding Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. tmpzr1t_l9r_go_relaxed.owl RNA polymerase II basal transcription factor binding krc 2010-10-28T02:30:02Z molecular_function owl:Class GO:1904486 biolink:NamedThing response to 17alpha-ethynylestradiol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus. tmpzr1t_l9r_go_relaxed.owl mr 2015-07-15T22:31:36Z biological_process owl:Class GO:1902637 biolink:NamedThing neural crest cell differentiation involved in thymus development Any neural crest cell differentiation that is involved in thymus development. tmpzr1t_l9r_go_relaxed.owl pr 2014-01-21T10:03:20Z biological_process owl:Class GO:0014033 biolink:NamedThing neural crest cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1990901 biolink:NamedThing old cell pole The cell pole distal from the most recent cell division. tmpzr1t_l9r_go_relaxed.owl pr 2015-11-17T16:42:16Z cellular_component owl:Class GO:0060187 biolink:NamedThing cell pole Either of two different areas at opposite ends of an axis of a cell. tmpzr1t_l9r_go_relaxed.owl Note that this term differs from 'cell tip ; GO:0051286' in that it is applicable to a broad range of cell shapes including spherical and cuboidal. cellular_component owl:Class GO:0034064 biolink:NamedThing Tor2-Mei2-Ste11 complex A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast. tmpzr1t_l9r_go_relaxed.owl cellular_component owl:Class GO:0075019 biolink:NamedThing negative regulation of appressorium formation Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont appressorium formation. tmpzr1t_l9r_go_relaxed.owl negative regulation of appressorium formation on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class GO:0080154 biolink:NamedThing regulation of fertilization Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). tmpzr1t_l9r_go_relaxed.owl dhl 2010-09-01T03:44:27Z biological_process owl:Class GO:0032943 biolink:NamedThing mononuclear cell proliferation The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. tmpzr1t_l9r_go_relaxed.owl PBMC proliferation|peripheral blood mononuclear cell proliferation biological_process owl:Class GO:0070661 biolink:NamedThing leukocyte proliferation The expansion of a leukocyte population by cell division. tmpzr1t_l9r_go_relaxed.owl mah 2009-05-28T05:25:28Z biological_process owl:Class GO:0090086 biolink:NamedThing negative regulation of protein deubiquitination Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein. tmpzr1t_l9r_go_relaxed.owl tb 2009-10-23T11:18:06Z biological_process owl:Class GO:0090085 biolink:NamedThing regulation of protein deubiquitination Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein. tmpzr1t_l9r_go_relaxed.owl tb 2009-10-23T11:16:32Z biological_process owl:Class GO:0034223 biolink:NamedThing regulation of ascospore wall chitin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin. tmpzr1t_l9r_go_relaxed.owl regulation of ascospore wall chitin synthesis|regulation of ascospore wall chitin formation|regulation of ascospore wall chitin anabolism|regulation of ascospore wall chitin biosynthesis biological_process owl:Class GO:0032995 biolink:NamedThing regulation of fungal-type cell wall biogenesis Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin. tmpzr1t_l9r_go_relaxed.owl regulation of chitin- and beta-glucan-containing cell wall biogenesis biological_process owl:Class GO:0070686 biolink:NamedThing macropinocytic cup membrane The portion of the plasma membrane surrounding a macropinocytic cup. tmpzr1t_l9r_go_relaxed.owl crown membrane mah 2009-06-03T10:52:25Z cellular_component owl:Class GO:0031253 biolink:NamedThing cell projection membrane The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. tmpzr1t_l9r_go_relaxed.owl membrane extension|membrane projection cellular_component owl:Class GO:0042082 biolink:NamedThing GSI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage. tmpzr1t_l9r_go_relaxed.owl GSI anchor formation|GPI/GSI anchor biosynthetic process|GSI anchor biosynthesis|GSI anchor anabolism|GSI anchor synthesis|GPI/GSI anchor biosynthesis biological_process owl:Class GO:0042081 biolink:NamedThing GSI anchor metabolic process The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane. tmpzr1t_l9r_go_relaxed.owl GSI anchor metabolism|GPI/GSI anchor metabolic process|GPI/GSI anchor metabolism biological_process owl:Class GO:2000539 biolink:NamedThing regulation of protein geranylgeranylation Any process that modulates the frequency, rate or extent of protein geranylgeranylation. tmpzr1t_l9r_go_relaxed.owl regulation of protein amino acid geranylgeranylation|regulation of C-terminal protein geranylgeranylation tb 2011-03-29T06:23:05Z biological_process owl:Class GO:0030448 biolink:NamedThing hyphal growth Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls. tmpzr1t_l9r_go_relaxed.owl formation of symbiont invasive hypha within host during symbiotic interaction|formation of symbiont invasive hypha within host|formation of symbiont invasive hypha in host|symbiont invasive hypha formation within host|invasive hyphal growth https://github.com/geneontology/go-ontology/issues/19013 GO:0075061 biological_process owl:Class GO:0030447 biolink:NamedThing filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0002866 biolink:NamedThing positive regulation of acute inflammatory response to antigenic stimulus Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. tmpzr1t_l9r_go_relaxed.owl up regulation of acute inflammatory response to antigenic stimulus|up-regulation of acute inflammatory response to antigenic stimulus|stimulation of acute inflammatory response to antigenic stimulus|upregulation of acute inflammatory response to antigenic stimulus|activation of acute inflammatory response to antigenic stimulus biological_process owl:Class GO:0002863 biolink:NamedThing positive regulation of inflammatory response to antigenic stimulus Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. tmpzr1t_l9r_go_relaxed.owl up-regulation of inflammatory response to antigenic stimulus|stimulation of inflammatory response to antigenic stimulus|up regulation of inflammatory response to antigenic stimulus|activation of inflammatory response to antigenic stimulus|upregulation of inflammatory response to antigenic stimulus biological_process owl:Class GO:0005851 biolink:NamedThing eukaryotic translation initiation factor 2B complex A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. tmpzr1t_l9r_go_relaxed.owl eIF-2B|eif2B cellular_component owl:Class GO:0080130 biolink:NamedThing L-phenylalanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate. tmpzr1t_l9r_go_relaxed.owl L-phenylalanine:alpha-ketoglutarate aminotransferase activity MetaCyc:RXN-10814|MetaCyc:PHEAMINOTRANS-RXN|KEGG_REACTION:R00694|RHEA:25152|EC:2.6.1.57 This reaction falls within the larger set of reactions associated with EC:2.6.1.57 and several other EC numbers (See BRENDA:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.57). dhl 2009-04-29T03:42:47Z molecular_function owl:Class GO:0070546 biolink:NamedThing L-phenylalanine aminotransferase activity Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0106256 biolink:NamedThing hydroperoxy icosatetraenoate dehydratase activity A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O. tmpzr1t_l9r_go_relaxed.owl EC:4.2.1.152|RHEA:55556 hjd 2020-03-20T14:40:16Z molecular_function owl:Class GO:0044249 biolink:NamedThing cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl cellular biosynthesis|cellular anabolism|cellular formation|cellular synthesis biological_process owl:Class GO:1905330 biolink:NamedThing regulation of morphogenesis of an epithelium Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. tmpzr1t_l9r_go_relaxed.owl regulation of epithelium morphogenesis An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). bhm 2016-07-22T07:13:49Z biological_process owl:Class GO:1902760 biolink:NamedThing Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of Mo(VI)-molybdopterin cytosine dinucleotide. tmpzr1t_l9r_go_relaxed.owl Mo-molybdopterin-cytosine-dinucleotide cofactor biosynthetic process|Mo(VI)-molybdopterin cytosine dinucleotide biosynthesis|Mo(VI)-molybdopterin cytosine dinucleotide synthesis|Mo(VI)-molybdopterin cytosine dinucleotide formation|Mo(VI)-molybdopterin cytosine dinucleotide anabolism MetaCyc:PWY-6476 dph 2014-03-06T14:00:43Z GO:0061601 biological_process owl:Class GO:0006777 biolink:NamedThing Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. tmpzr1t_l9r_go_relaxed.owl Mo-molybdopterin cofactor formation|Moco biosynthetic process|Mo-molybdopterin cofactor anabolism|Mo-molybdopterin cofactor synthesis|Mo-molybdopterin cofactor biosynthesis|Moco biosynthesis|molybdenum cofactor biosynthetic process MetaCyc:PWY-6823 biological_process owl:Class GO:0061425 biolink:NamedThing positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process. tmpzr1t_l9r_go_relaxed.owl dph 2012-02-02T01:12:36Z biological_process owl:Class GO:1900066 biolink:NamedThing positive regulation of ethanol catabolic process Any process that activates or increases the frequency, rate or extent of ethanol catabolic process. tmpzr1t_l9r_go_relaxed.owl positive regulation of ethanol catabolism|upregulation of ethanol catabolism|up-regulation of ethanol catabolism|up-regulation of ethanol catabolic process|up regulation of ethanol catabolic process|positive regulation of ethanol breakdown|upregulation of ethanol catabolic process|activation of ethanol catabolism|activation of ethanol degradation|activation of ethanol breakdown|activation of ethanol catabolic process|upregulation of ethanol breakdown|up regulation of ethanol catabolism|up regulation of ethanol breakdown|upregulation of ethanol degradation|up-regulation of ethanol breakdown|up-regulation of ethanol degradation|up regulation of ethanol degradation|positive regulation of ethanol degradation dph 2012-01-26T01:51:44Z biological_process owl:Class GO:0071803 biolink:NamedThing positive regulation of podosome assembly Any process that activates or increases the rate or extent of podosome assembly. tmpzr1t_l9r_go_relaxed.owl stimulation of podosome assembly|activation of podosome assembly|up regulation of podosome assembly|up-regulation of podosome assembly|upregulation of podosome assembly mah 2010-09-03T01:50:50Z biological_process owl:Class GO:0099551 biolink:NamedThing trans-synaptic signaling by neuropeptide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. tmpzr1t_l9r_go_relaxed.owl Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class GO:0045040 biolink:NamedThing protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes. tmpzr1t_l9r_go_relaxed.owl mitochondrial outer membrane protein import|protein import into mitochondrial outer membrane|protein transport into mitochondrial outer membrane biological_process owl:Class GO:0051204 biolink:NamedThing protein insertion into mitochondrial membrane The process that results in the incorporation of a protein into a mitochondrial membrane. tmpzr1t_l9r_go_relaxed.owl integral mitochondrial membrane protein positioning|protein insertion into mitochondrion membrane|localization of protein in mitochondrial membrane|integral mitochondrial membrane protein localization|protein-mitochondrion membrane insertion|positioning of protein in mitochondrial membrane|protein-mitochondrial membrane insertion https://github.com/geneontology/go-ontology/issues/15800 biological_process owl:Class GO:0034355 biolink:NamedThing NAD salvage Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam). tmpzr1t_l9r_go_relaxed.owl NAD salvage pathway biological_process owl:Class GO:0019365 biolink:NamedThing pyridine nucleotide salvage Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis. tmpzr1t_l9r_go_relaxed.owl pyridine nucleotide cycling biological_process owl:Class GO:1900076 biolink:NamedThing regulation of cellular response to insulin stimulus Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. tmpzr1t_l9r_go_relaxed.owl yaf 2012-01-31T11:22:22Z biological_process owl:Class GO:0031654 biolink:NamedThing regulation of heat dissipation Any process that modulates the rate or extent of heat dissipation. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0051239 biolink:NamedThing regulation of multicellular organismal process Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1902214 biolink:NamedThing regulation of interleukin-4-mediated signaling pathway Any process that modulates the frequency, rate or extent of interleukin-4-mediated signaling pathway. tmpzr1t_l9r_go_relaxed.owl regulation of interleukin-4-mediated signalling pathway|regulation of IL-4-mediated signaling pathway lb 2013-06-12T12:53:09Z biological_process owl:Class GO:0048021 biolink:NamedThing regulation of melanin biosynthetic process Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin. tmpzr1t_l9r_go_relaxed.owl regulation of melanin anabolism|regulation of melanin biosynthesis|regulation of melanin synthesis|regulation of melanin formation biological_process owl:Class GO:0032270 biolink:NamedThing positive regulation of cellular protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. tmpzr1t_l9r_go_relaxed.owl upregulation of cellular protein metabolic process|up-regulation of cellular protein metabolic process|up regulation of cellular protein metabolic process|positive regulation of cellular protein metabolism|activation of cellular protein metabolic process|stimulation of cellular protein metabolic process biological_process owl:Class GO:0031325 biolink:NamedThing positive regulation of cellular metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. tmpzr1t_l9r_go_relaxed.owl positive regulation of cellular metabolism|upregulation of cellular metabolic process|up regulation of cellular metabolic process|activation of cellular metabolic process|up-regulation of cellular metabolic process|stimulation of cellular metabolic process biological_process owl:Class GO:0044477 biolink:NamedThing envenomation resulting in negative regulation of platelet aggregation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism. tmpzr1t_l9r_go_relaxed.owl jl 2012-01-19T02:36:44Z biological_process owl:Class GO:0035738 biolink:NamedThing envenomation resulting in modulation of process in other organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism. tmpzr1t_l9r_go_relaxed.owl envenomation resulting in modification of morphology or physiology of other organism https://github.com/geneontology/go-ontology/issues/18605 bf 2011-03-17T10:59:27Z biological_process owl:Class GO:0046793 biolink:NamedThing induction by virus of phosphorylation of host RNA polymerase II Any process in which a virus activates the frequency, rate or extent of phosphorylation of host RNA polymerase II. tmpzr1t_l9r_go_relaxed.owl virus-induced modification of host RNA polymerase II|induction by virus of modification of host RNA polymerase II biological_process owl:Class GO:0039614 biolink:NamedThing induction by virus of host protein phosphorylation Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host. tmpzr1t_l9r_go_relaxed.owl bf 2012-07-06T11:15:56Z biological_process owl:Class GO:1903147 biolink:NamedThing negative regulation of autophagy of mitochondrion Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation by autophagy. tmpzr1t_l9r_go_relaxed.owl inhibition of mitochondrion degradation|down regulation of mitochondrion degradation|downregulation of mitochondrion degradation|inhibition of mitophagy|down-regulation of mitochondrion degradation|down regulation of mitochondrial degradation|down-regulation of mitophagy bf 2014-07-09T08:23:58Z biological_process owl:Class GO:0050925 biolink:NamedThing negative regulation of negative chemotaxis Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. tmpzr1t_l9r_go_relaxed.owl inhibition of negative chemotaxis|downregulation of negative chemotaxis|down regulation of negative chemotaxis|down-regulation of negative chemotaxis biological_process owl:Class GO:0050923 biolink:NamedThing regulation of negative chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1904449 biolink:NamedThing negative regulation of aspartate secretion Any process that stops, prevents or reduces the frequency, rate or extent of aspartate secretion. tmpzr1t_l9r_go_relaxed.owl inhibition of aspartate secretion|downregulation of aspartate secretion|down regulation of aspartate secretion|down-regulation of aspartate secretion sl 2015-07-07T20:57:04Z biological_process owl:Class GO:0031147 biolink:NamedThing 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells. tmpzr1t_l9r_go_relaxed.owl 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism|DIF-1 metabolic process|DIF-1 metabolism biological_process owl:Class GO:0034051 biolink:NamedThing negative regulation of plant-type hypersensitive response Any process that stops, prevents, or reduces the frequency, rate or extent of the hypersensitive response in a plant. tmpzr1t_l9r_go_relaxed.owl negative regulation of HR|negative regulation of HR-PCD|downregulation of plant-type hypersensitive response|negative regulation of plant hypersensitive response|down regulation of plant-type hypersensitive response|down-regulation of plant-type hypersensitive response|inhibition of plant-type hypersensitive response biological_process owl:Class GO:0010363 biolink:NamedThing regulation of plant-type hypersensitive response Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response. tmpzr1t_l9r_go_relaxed.owl regulation of HR|regulation of HR-PCD|regulation of plant hypersensitive response Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'. biological_process owl:Class GO:1904848 biolink:NamedThing negative regulation of cell chemotaxis to fibroblast growth factor Any process that stops, prevents or reduces the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. tmpzr1t_l9r_go_relaxed.owl downregulation of cell chemotaxis to fibroblast growth factor|down regulation of cell chemotaxis to fibroblast growth factor|inhibition of cell chemotaxis to fibroblast growth factor|down-regulation of cell chemotaxis to fibroblast growth factor rph 2015-12-10T12:04:08Z biological_process owl:Class GO:0090288 biolink:NamedThing negative regulation of cellular response to growth factor stimulus Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. tmpzr1t_l9r_go_relaxed.owl tb 2010-02-18T03:01:25Z biological_process owl:Class GO:0044065 biolink:NamedThing regulation of respiratory system process Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0102281 biolink:NamedThing formylaminopyrimidine deformylase activity Catalysis of the reaction: formylaminopyrimidine + H2O <=> 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-12612 molecular_function owl:Class GO:0016811 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-9673053|Reactome:R-HSA-9673054|EC:3.5.1.- molecular_function owl:Class GO:0007553 biolink:NamedThing regulation of ecdysteroid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females. tmpzr1t_l9r_go_relaxed.owl regulation of ecdysteroid metabolism biological_process owl:Class GO:0032350 biolink:NamedThing regulation of hormone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. tmpzr1t_l9r_go_relaxed.owl regulation of hormone metabolism biological_process owl:Class GO:1903096 biolink:NamedThing protein localization to meiotic spindle midzone A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone. tmpzr1t_l9r_go_relaxed.owl protein localisation in meiotic spindle midzone|protein localisation to meiotic spindle midzone|protein localization in meiotic spindle midzone kmv 2014-06-03T16:06:22Z biological_process owl:Class GO:1905359 biolink:NamedThing protein localization to meiotic spindle A process in which a protein is transported to, or maintained in, a location within a meiotic spindle. tmpzr1t_l9r_go_relaxed.owl protein localisation to meiotic spindle mah 2016-08-10T14:49:03Z biological_process owl:Class GO:2000396 biolink:NamedThing negative regulation of ubiquitin-dependent endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis. tmpzr1t_l9r_go_relaxed.owl negative regulation of ubiquitin-mediated endocytosis mah 2011-02-22T11:25:21Z biological_process owl:Class GO:0045806 biolink:NamedThing negative regulation of endocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. tmpzr1t_l9r_go_relaxed.owl down-regulation of endocytosis|inhibition of endocytosis|downregulation of endocytosis|down regulation of endocytosis biological_process owl:Class GO:2000048 biolink:NamedThing negative regulation of cell-cell adhesion mediated by cadherin Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin. tmpzr1t_l9r_go_relaxed.owl jl 2010-08-20T12:56:51Z biological_process owl:Class GO:0061043 biolink:NamedThing regulation of vascular wound healing Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. tmpzr1t_l9r_go_relaxed.owl dph 2010-02-25T10:21:59Z biological_process owl:Class GO:0045765 biolink:NamedThing regulation of angiogenesis Any process that modulates the frequency, rate or extent of angiogenesis. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:2001105 biolink:NamedThing maltoheptaose transport The directed movement of a maltoheptaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl jl 2011-09-21T02:31:22Z biological_process owl:Class GO:2001104 biolink:NamedThing heptasaccharide transport The directed movement of a heptasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl jl 2011-09-21T02:29:58Z biological_process owl:Class GO:0015859 biolink:NamedThing intracellular nucleoside transport The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0015858 biolink:NamedThing nucleoside transport The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0043377 biolink:NamedThing negative regulation of CD8-positive, alpha-beta T cell differentiation Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation. tmpzr1t_l9r_go_relaxed.owl negative regulation of CD8-positive, alpha-beta T cell development|downregulation of CD8-positive, alpha-beta T cell differentiation|down-regulation of CD8-positive, alpha-beta T cell differentiation|negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation|negative regulation of CD8-positive T-cell differentiation|negative regulation of CD8-positive, alpha beta T-cell differentiation|negative regulation of CD8-positive T lymphocyte differentiation|down regulation of CD8-positive, alpha-beta T cell differentiation|negative regulation of CD8-positive, alpha beta T lymphocyte differentiation|inhibition of CD8-positive, alpha-beta T cell differentiation|negative regulation of CD8-positive T-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:1905388 biolink:NamedThing cellular response to beta-carotene Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus. tmpzr1t_l9r_go_relaxed.owl cellular response to beta,beta-carotene sl 2016-08-18T16:18:31Z biological_process owl:Class GO:1905387 biolink:NamedThing response to beta-carotene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus. tmpzr1t_l9r_go_relaxed.owl response to beta,beta-carotene sl 2016-08-18T16:18:24Z biological_process owl:Class GO:0010712 biolink:NamedThing regulation of collagen metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. tmpzr1t_l9r_go_relaxed.owl regulation of collagen metabolism biological_process owl:Class GO:0003128 biolink:NamedThing heart field specification The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop. tmpzr1t_l9r_go_relaxed.owl tb 2009-09-22T02:56:05Z biological_process owl:Class GO:0010092 biolink:NamedThing specification of animal organ identity The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0030711 biolink:NamedThing positive regulation of border follicle cell delamination Any process that increases the frequency, rate or extent of border cell delamination. tmpzr1t_l9r_go_relaxed.owl stimulation of border follicle cell delamination|up regulation of border follicle cell delamination|up-regulation of border follicle cell delamination|positive regulation of border cell delamination|activation of border follicle cell delamination|upregulation of border follicle cell delamination biological_process owl:Class GO:0021582 biolink:NamedThing medulla oblongata maturation A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. tmpzr1t_l9r_go_relaxed.owl myelencephalon maturation|medulla maturation biological_process owl:Class GO:0071695 biolink:NamedThing anatomical structure maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. tmpzr1t_l9r_go_relaxed.owl mah 2010-03-02T11:43:38Z biological_process owl:Class GO:0050814 biolink:NamedThing epothilone biosynthetic process The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer. tmpzr1t_l9r_go_relaxed.owl epothilone anabolism|epothilone biosynthesis|epothilone synthesis|epothilone formation biological_process owl:Class GO:0097634 biolink:NamedThing integral component of phagophore assembly site membrane The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. tmpzr1t_l9r_go_relaxed.owl integral to phagophore assembly site membrane|phagophore assembly site integral membrane protein cellular_component owl:Class GO:0097633 biolink:NamedThing intrinsic component of phagophore assembly site membrane The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. tmpzr1t_l9r_go_relaxed.owl intrinsic to phagophore assembly site membrane cellular_component owl:Class GO:1900664 biolink:NamedThing regulation of emodin biosynthetic process Any process that modulates the frequency, rate or extent of emodin biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of emodin anabolism|regulation of emodin synthesis|regulation of emodin formation|regulation of emodin biosynthesis di 2012-05-22T04:14:36Z biological_process owl:Class GO:1900376 biolink:NamedThing regulation of secondary metabolite biosynthetic process Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of secondary metabolite biosynthesis di 2012-04-17T01:55:23Z biological_process owl:Class GO:0019332 biolink:NamedThing aerobic respiration, using nitrite as electron donor The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species. tmpzr1t_l9r_go_relaxed.owl nitrite oxidation MetaCyc:P282-PWY biological_process owl:Class GO:0015975 biolink:NamedThing energy derivation by oxidation of reduced inorganic compounds The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released. tmpzr1t_l9r_go_relaxed.owl chemolithotrophie|lithotrophy|chemolithotrophy Wikipedia:Lithotrophy biological_process owl:Class GO:0098501 biolink:NamedThing polynucleotide dephosphorylation The process of removing one or more phosphate groups from a polynucleotide. tmpzr1t_l9r_go_relaxed.owl dos 2013-09-18T14:49:10Z biological_process owl:Class GO:0016311 biolink:NamedThing dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Dephosphorylation biological_process owl:Class GO:1905652 biolink:NamedThing negative regulation of artery morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. tmpzr1t_l9r_go_relaxed.owl inhibition of artery morphogenesis|downregulation of arterial morphogenesis|down-regulation of artery morphogenesis|downregulation of arteriogenesis|inhibition of arteriogenesis|negative regulation of arterial morphogenesis|down regulation of arteriogenesis|down-regulation of arteriogenesis|negative regulation of arteriogenesis|down regulation of artery morphogenesis|inhibition of arterial morphogenesis|down regulation of arterial morphogenesis|down-regulation of arterial morphogenesis|downregulation of artery morphogenesis rph 2016-11-09T12:19:53Z biological_process owl:Class GO:1905651 biolink:NamedThing regulation of artery morphogenesis Any process that modulates the frequency, rate or extent of artery morphogenesis. tmpzr1t_l9r_go_relaxed.owl regulation of arteriogenesis|regulation of arterial morphogenesis rph 2016-11-09T12:19:37Z biological_process owl:Class GO:1900867 biolink:NamedThing sarcinapterin metabolic process The chemical reactions and pathways involving sarcinapterin. tmpzr1t_l9r_go_relaxed.owl sarcinapterin metabolism tt 2012-06-12T04:34:10Z biological_process owl:Class GO:0072350 biolink:NamedThing tricarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). tmpzr1t_l9r_go_relaxed.owl tricarboxylic acid metabolism mah 2010-11-11T05:07:30Z biological_process owl:Class GO:0005513 biolink:NamedThing detection of calcium ion The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. tmpzr1t_l9r_go_relaxed.owl calcium ion detection|detection of Ca2+ ion|calcium ion sensing|Ca2+ ion detection biological_process owl:Class GO:0009593 biolink:NamedThing detection of chemical stimulus The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. tmpzr1t_l9r_go_relaxed.owl perception of chemical stimulus|chemoperception|chemoreception|detection of chemical substance|perception of chemical substance biological_process owl:Class GO:0034075 biolink:NamedThing arabidiol synthase activity Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol). tmpzr1t_l9r_go_relaxed.owl RHEA:31035|EC:4.2.1.124|MetaCyc:RXN-9684 molecular_function owl:Class GO:0031559 biolink:NamedThing oxidosqualene cyclase activity Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene. tmpzr1t_l9r_go_relaxed.owl 2,3-oxidosqualene cyclase activity Note that the phrase 'oxidosqualene cyclase' has been used to refer to enzymes that catalyze the reaction represented by 'lanosterol synthase activity ; GO:0000250'. molecular_function owl:Class GO:0140669 biolink:NamedThing negative regulation of oxytocin production Any process that stops, prevents, or reduces the rate of production of oxytocin. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/21535 pg 2021-06-24T11:31:45Z biological_process owl:Class GO:0035052 biolink:NamedThing dorsal vessel aortic cell fate commitment The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0045821 biolink:NamedThing positive regulation of glycolytic process Any process that activates or increases the frequency, rate or extent of glycolysis. tmpzr1t_l9r_go_relaxed.owl activation of glycolysis|up regulation of glycolysis|stimulation of glycolysis|upregulation of glycolysis|up-regulation of glycolysis biological_process owl:Class GO:0042327 biolink:NamedThing positive regulation of phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. tmpzr1t_l9r_go_relaxed.owl stimulation of phosphorylation|up regulation of phosphorylation|up-regulation of phosphorylation|upregulation of phosphorylation|activation of phosphorylation biological_process owl:Class GO:1900384 biolink:NamedThing regulation of flavonol biosynthetic process Any process that modulates the frequency, rate or extent of flavonol biosynthetic process. tmpzr1t_l9r_go_relaxed.owl tb 2012-04-17T10:22:49Z biological_process owl:Class GO:1902210 biolink:NamedThing positive regulation of bacterial-type flagellum assembly Any process that activates or increases the frequency, rate or extent of bacterial-type flagellum assembly. tmpzr1t_l9r_go_relaxed.owl up-regulation of bacterial flagellum assembly|up regulation of bacterial-type flagellum assembly|up-regulation of bacterial-type flagellum assembly|upregulation of bacterial-type flagellum assembly|activation of bacterial-type flagellum assembly|activation of bacterial flagellum assembly|up regulation of bacterial flagellum assembly|upregulation of bacterial flagellum assembly|positive regulation of bacterial flagellum assembly jl 2013-06-11T14:20:30Z biological_process owl:Class GO:0031346 biolink:NamedThing positive regulation of cell projection organization Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. tmpzr1t_l9r_go_relaxed.owl up-regulation of cell projection organization|stimulation of cell projection organization|activation of cell projection organization|positive regulation of cell projection organisation|up regulation of cell projection organization|upregulation of cell projection organization|positive regulation of cell projection organization and biogenesis biological_process owl:Class GO:1903209 biolink:NamedThing positive regulation of oxidative stress-induced cell death Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death. tmpzr1t_l9r_go_relaxed.owl up regulation of cell death in response to oxidative stress|up-regulation of cell death in response to oxidative stress|enhancement of oxidative stress-induced cell death|positive regulation of cell death in response to oxidative stress|activation of cell death in response to oxidative stress|upregulation of cell death in response to oxidative stress bf 2014-07-22T09:32:19Z biological_process owl:Class GO:0042149 biolink:NamedThing cellular response to glucose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0009267 biolink:NamedThing cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1900110 biolink:NamedThing negative regulation of histone H3-K9 dimethylation Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 dimethylation. tmpzr1t_l9r_go_relaxed.owl down regulation of histone lysine H3 K9 dimethylation|inhibition of histone H3 K9 dimethylation|negative regulation of histone lysine H3 K9 dimethylation|down-regulation of histone H3-K9 dimethylation|downregulation of histone lysine H3 K9 dimethylation|inhibition of histone H3-K9 dimethylation|downregulation of histone H3-K9 dimethylation|negative regulation of histone H3 K9 dimethylation|down-regulation of histone H3 K9 dimethylation|downregulation of histone H3 K9 dimethylation|down-regulation of histone lysine H3 K9 dimethylation|down regulation of histone H3 K9 dimethylation|inhibition of histone lysine H3 K9 dimethylation|down regulation of histone H3-K9 dimethylation bf 2012-02-21T09:06:22Z biological_process owl:Class GO:1900109 biolink:NamedThing regulation of histone H3-K9 dimethylation Any process that modulates the frequency, rate or extent of histone H3-K9 dimethylation. tmpzr1t_l9r_go_relaxed.owl regulation of histone H3 K9 dimethylation|regulation of histone lysine H3 K9 dimethylation bf 2012-02-21T09:06:18Z biological_process owl:Class GO:0044747 biolink:NamedThing mature miRNA 3'-end processing Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends. tmpzr1t_l9r_go_relaxed.owl miRNA trimming|miRNA 3'-end processing|miRNA 3' end terminal trimming jl 2012-11-15T13:45:21Z biological_process owl:Class GO:1904811 biolink:NamedThing positive regulation of dense core granule transport Any process that activates or increases the frequency, rate or extent of dense core granule transport. tmpzr1t_l9r_go_relaxed.owl upregulation of dense core granule transport|activation of dense core vesicle transport|positive regulation of dense core vesicle transport|up regulation of dense core vesicle transport|up regulation of dense core granule transport|upregulation of dense core vesicle transport|up-regulation of dense core granule transport|up-regulation of dense core vesicle transport|activation of dense core granule transport cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). es 2015-11-11T10:40:25Z biological_process owl:Class GO:0044533 biolink:NamedThing positive regulation of apoptotic process in other organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism. tmpzr1t_l9r_go_relaxed.owl jl 2012-03-21T11:25:24Z biological_process owl:Class GO:0044532 biolink:NamedThing modulation of apoptotic process in other organism A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism. tmpzr1t_l9r_go_relaxed.owl regulation of apoptotic process in other organism jl 2012-03-21T11:17:18Z biological_process owl:Class GO:0005883 biolink:NamedThing neurofilament A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter. tmpzr1t_l9r_go_relaxed.owl type IV intermediate filament Wikipedia:Neurofilament|NIF_Subcellular:sao1316272517 cellular_component owl:Class GO:0005882 biolink:NamedThing intermediate filament A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. tmpzr1t_l9r_go_relaxed.owl type I intermediate filament associated protein|type II intermediate filament associated protein|intermediate filament associated protein FMA:63851|NIF_Subcellular:sao952483289|Wikipedia:Intermediate_filament cellular_component owl:Class GO:0006364 biolink:NamedThing rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. tmpzr1t_l9r_go_relaxed.owl 35S primary transcript processing GO:0006365 biological_process owl:Class GO:0034470 biolink:NamedThing ncRNA processing Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0009737 biolink:NamedThing response to abscisic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. tmpzr1t_l9r_go_relaxed.owl response to abscisic acid stimulus biological_process owl:Class GO:0033993 biolink:NamedThing response to lipid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:2000091 biolink:NamedThing negative regulation of mesonephric glomerular mesangial cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation. tmpzr1t_l9r_go_relaxed.owl dph 2010-09-03T06:10:31Z biological_process owl:Class GO:0030920 biolink:NamedThing peptidyl-serine acetylation The acetylation of peptidyl-serine. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0006473 biolink:NamedThing protein acetylation The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. tmpzr1t_l9r_go_relaxed.owl protein amino acid acetylation biological_process owl:Class GO:2000078 biolink:NamedThing positive regulation of type B pancreatic cell development Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. tmpzr1t_l9r_go_relaxed.owl positive regulation of pancreatic B cell development|positive regulation of pancreatic beta cell development tb 2010-08-27T11:21:19Z biological_process owl:Class GO:0070341 biolink:NamedThing fat cell proliferation The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. tmpzr1t_l9r_go_relaxed.owl adipocyte proliferation|adipose cell proliferation biological_process owl:Class GO:2000370 biolink:NamedThing positive regulation of clathrin-dependent endocytosis Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis. tmpzr1t_l9r_go_relaxed.owl positive regulation of clathrin-mediated endocytosis|positive regulation of clathrin coated pit-dependent endocytosis mah 2011-02-09T12:36:28Z biological_process owl:Class GO:0070257 biolink:NamedThing positive regulation of mucus secretion Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. tmpzr1t_l9r_go_relaxed.owl positive regulation of mucus production biological_process owl:Class GO:0070255 biolink:NamedThing regulation of mucus secretion Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. tmpzr1t_l9r_go_relaxed.owl regulation of mucus production biological_process owl:Class GO:0106151 biolink:NamedThing CNBH domain intrinsic ligand binding Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide. tmpzr1t_l9r_go_relaxed.owl It is unclear if the motif bound by CNBHD is a specific motif or just a beta sheet with the appropriate amino acids. hjd 2018-09-18T20:47:35Z molecular_function owl:Class GO:0006269 biolink:NamedThing DNA replication, synthesis of RNA primer The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. tmpzr1t_l9r_go_relaxed.owl replication priming biological_process owl:Class GO:0032774 biolink:NamedThing RNA biosynthetic process The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. tmpzr1t_l9r_go_relaxed.owl RNA synthesis|RNA biosynthesis|RNA anabolism|RNA formation Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. biological_process owl:Class GO:1901176 biolink:NamedThing lycopene catabolic process The chemical reactions and pathways resulting in the breakdown of lycopene. tmpzr1t_l9r_go_relaxed.owl lycopene degradation|lycopene catabolism|lycopene breakdown yaf 2012-07-19T09:48:41Z biological_process owl:Class GO:0016121 biolink:NamedThing carotene catabolic process The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids. tmpzr1t_l9r_go_relaxed.owl carotene breakdown|carotene catabolism|carotene degradation biological_process owl:Class GO:1904154 biolink:NamedThing positive regulation of retrograde protein transport, ER to cytosol Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol. tmpzr1t_l9r_go_relaxed.owl upregulation of protein dislocation from ER|activation of retrograde protein transport, endoplasmic reticulum to cytosol|up regulation of protein dislocation from ER|positive regulation of retrograde protein transport, endoplasmic reticulum to cytosol|up-regulation of retrograde protein transport, ER to cytosol|up-regulation of retrograde protein transport, endoplasmic reticulum to cytosol|upregulation of retrograde protein transport, ER to cytosol|up-regulation of protein dislocation from ER|positive regulation of protein retrotranslocation from ER|up regulation of retrograde protein transport, endoplasmic reticulum to cytosol|up regulation of retrograde protein transport, ER to cytosol|activation of retrograde protein transport, ER to cytosol|upregulation of retrograde protein transport, endoplasmic reticulum to cytosol|activation of protein dislocation from ER|up-regulation of protein retrotranslocation from ER|positive regulation of protein dislocation from ER bf 2015-04-15T09:23:19Z biological_process owl:Class GO:0070863 biolink:NamedThing positive regulation of protein exit from endoplasmic reticulum Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum. tmpzr1t_l9r_go_relaxed.owl stimulation of protein exit from endoplasmic reticulum|positive regulation of protein export from endoplasmic reticulum|upregulation of protein exit from endoplasmic reticulum|up-regulation of protein exit from endoplasmic reticulum|positive regulation of protein export from ER|up regulation of protein exit from endoplasmic reticulum|positive regulation of protein exit from ER|activation of protein exit from endoplasmic reticulum mah 2009-08-17T03:50:04Z biological_process owl:Class GO:1904415 biolink:NamedThing regulation of xenophagy Any process that modulates the frequency, rate or extent of xenophagy. tmpzr1t_l9r_go_relaxed.owl An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). pad 2015-06-29T12:30:47Z biological_process owl:Class GO:0006210 biolink:NamedThing thymine catabolic process The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. tmpzr1t_l9r_go_relaxed.owl thymine catabolism|thymine breakdown|thymine degradation biological_process owl:Class GO:0019859 biolink:NamedThing thymine metabolic process The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. tmpzr1t_l9r_go_relaxed.owl thymine metabolism biological_process owl:Class GO:0002754 biolink:NamedThing intracellular endosomal pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of an intracellular vesicle pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. tmpzr1t_l9r_go_relaxed.owl intracellular vesicle pathogen receptor signaling pathway|intracellular vesicle pattern recognition receptor signalling pathway|intracellular vesicle pattern recognition receptor signaling pathway|intracellular vesicle PRR signaling pathway|intracellular vesicle PAMP receptor signaling pathway https://github.com/geneontology/go-ontology/issues/18679 biological_process owl:Class GO:0002221 biolink:NamedThing pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. tmpzr1t_l9r_go_relaxed.owl PAMP receptor signaling pathway|PRR signaling pathway|pathogen receptor signaling pathway|pathogen receptor signalling pathway https://github.com/geneontology/go-ontology/issues/18588 biological_process owl:Class GO:0034055 biolink:NamedThing effector-mediated induction of programmed cell death in host A symbiont process in which a molecule secreted by the symbiont activates a programmed cell death pathway in the host to suppress the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl up-regulation by symbiont of host defense-related programmed cell death|upregulation by symbiont of host defense-related programmed cell death|enhancement by symbiont of host defense-related programmed cell death|up regulation by symbiont of host defense-related programmed cell death|stimulation by symbiont of host defense-related programmed cell death|positive regulation by symbiont of host defense-related PCD|positive regulation by symbiont of host defense-related programmed cell death|activation by symbiont of host defense-related programmed cell death https://github.com/geneontology/go-ontology/issues/20284 Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class GO:0140418 biolink:NamedThing effector-mediated modulation of host process by symbiont A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction. tmpzr1t_l9r_go_relaxed.owl effector mediated modulation of host process by symbiont|effector triggered modulation of host process by symbiont|effector-dependent modulation of host process by symbiont https://github.com/geneontology/go-ontology/issues/18605|https://github.com/geneontology/go-ontology/issues/20971 pg 2020-01-29T21:24:42Z biological_process owl:Class GO:0010396 biolink:NamedThing rhamnogalacturonan II metabolic process The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues. tmpzr1t_l9r_go_relaxed.owl rhamnogalacturonan II metabolism biological_process owl:Class GO:0010393 biolink:NamedThing galacturonan metabolic process The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues. tmpzr1t_l9r_go_relaxed.owl galacturonan metabolism biological_process owl:Class GO:0044505 biolink:NamedThing positive regulation of G protein-coupled receptor activity in other organism A process that activates or increases the frequency, rate or extent of the activity of a G protein-coupled receptor in a second organism. tmpzr1t_l9r_go_relaxed.owl positive regulation of G-protein coupled receptor activity in other organism|regulation of G-protein coupled receptor activity in other organism jl 2012-02-23T04:24:17Z biological_process owl:Class GO:2000273 biolink:NamedThing positive regulation of signaling receptor activity Any process that activates or increases the frequency, rate or extent of signaling receptor activity. tmpzr1t_l9r_go_relaxed.owl positive regulation of signalling receptor activity bf 2010-12-02T09:28:50Z biological_process owl:Class GO:0051628 biolink:NamedThing positive regulation of epinephrine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell. tmpzr1t_l9r_go_relaxed.owl positive regulation of adrenaline uptake|activation of epinephrine uptake|up-regulation of epinephrine uptake|up regulation of epinephrine uptake|positive regulation of epinephrine import|stimulation of epinephrine uptake|upregulation of epinephrine uptake biological_process owl:Class GO:0051626 biolink:NamedThing regulation of epinephrine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell. tmpzr1t_l9r_go_relaxed.owl regulation of epinephrine import|regulation of adrenaline uptake biological_process owl:Class GO:0006303 biolink:NamedThing double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. tmpzr1t_l9r_go_relaxed.owl NHEJ biological_process owl:Class GO:0006302 biolink:NamedThing double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. tmpzr1t_l9r_go_relaxed.owl Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'. biological_process owl:Class GO:1901110 biolink:NamedThing actinorhodin metabolic process The chemical reactions and pathways involving actinorhodin. tmpzr1t_l9r_go_relaxed.owl actinorhodin metabolism yaf 2012-07-11T03:05:37Z biological_process owl:Class GO:1903027 biolink:NamedThing regulation of opsonization Any process that modulates the frequency, rate or extent of opsonization. tmpzr1t_l9r_go_relaxed.owl rl 2014-05-16T17:34:41Z biological_process owl:Class GO:1901889 biolink:NamedThing negative regulation of cell junction assembly Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. tmpzr1t_l9r_go_relaxed.owl inhibition of cell junction assembly|down regulation of cell junction assembly|down-regulation of cell junction assembly|downregulation of cell junction assembly tb 2013-02-06T19:40:41Z biological_process owl:Class GO:1901888 biolink:NamedThing regulation of cell junction assembly Any process that modulates the frequency, rate or extent of cell junction assembly. tmpzr1t_l9r_go_relaxed.owl tb 2013-02-06T19:40:32Z biological_process owl:Class GO:0015958 biolink:NamedThing bis(5'-nucleosidyl) oligophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. tmpzr1t_l9r_go_relaxed.owl bis(5'-nucleosidyl) oligophosphate catabolism|bis(5'-nucleosidyl) oligophosphate breakdown|bis(5'-nucleosidyl) oligophosphate degradation biological_process owl:Class GO:0009166 biolink:NamedThing nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). tmpzr1t_l9r_go_relaxed.owl nucleotide catabolism|nucleotide degradation|nucleotide breakdown biological_process owl:Class GO:0042204 biolink:NamedThing s-triazine compound catabolic process The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms. tmpzr1t_l9r_go_relaxed.owl s-triazine compound degradation|s-triazine compound catabolism|s-triazine compound breakdown UM-BBD_pathwayID:tria biological_process owl:Class GO:0042178 biolink:NamedThing xenobiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. tmpzr1t_l9r_go_relaxed.owl exogenous drug degradation|exogenous drug catabolism|xenobiotic degradation|exogenous drug catabolic process|xenobiotic breakdown|drug catabolism|xenobiotic catabolism|drug catabolic process|drug breakdown|exogenous drug breakdown|drug degradation https://github.com/geneontology/go-ontology/issues/19460 GO:0042737|GO:0042738 biological_process owl:Class GO:1905130 biolink:NamedThing carcinine import across plasma membrane The directed movement of carcinine from outside of a cell, across the plasma membrane and into the cytosol. tmpzr1t_l9r_go_relaxed.owl dph 2016-04-12T15:15:18Z biological_process owl:Class GO:0045117 biolink:NamedThing azole transmembrane transport The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane. tmpzr1t_l9r_go_relaxed.owl azole transport biological_process owl:Class GO:2000995 biolink:NamedThing negative regulation of mannan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process. tmpzr1t_l9r_go_relaxed.owl negative regulation of mannan breakdown|negative regulation of mannan catabolism|negative regulation of mannan degradation tt 2011-08-08T03:19:11Z biological_process owl:Class GO:2000994 biolink:NamedThing regulation of mannan catabolic process Any process that modulates the frequency, rate or extent of mannan catabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of mannan catabolism|regulation of mannan breakdown|regulation of mannan degradation tt 2011-08-08T03:19:03Z biological_process owl:Class GO:0034389 biolink:NamedThing lipid droplet organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. tmpzr1t_l9r_go_relaxed.owl lipid particle organization|adiposome organization|lipid particle organisation|lipid body organization|lipid particle organization and biogenesis https://github.com/geneontology/go-ontology/issues/15963|https://github.com/geneontology/go-ontology/issues/13534 biological_process owl:Class GO:0006996 biolink:NamedThing organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. tmpzr1t_l9r_go_relaxed.owl organelle organisation|single-organism organelle organization|organelle organization and biogenesis|single organism organelle organization jl 2013-12-19T15:25:51Z GO:1902589 biological_process owl:Class GO:0010746 biolink:NamedThing regulation of long-chain fatty acid import across plasma membrane Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. tmpzr1t_l9r_go_relaxed.owl regulation of plasma membrane long-chain fatty acid transport biological_process owl:Class GO:0034762 biolink:NamedThing regulation of transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl regulation of membrane transport biological_process owl:Class GO:0033864 biolink:NamedThing positive regulation of NAD(P)H oxidase activity Any process that activates or increases the activity of the enzyme NAD(P)H oxidase. tmpzr1t_l9r_go_relaxed.owl stimulation of NAD(P)H oxidase activity|up-regulation of NAD(P)H oxidase activity|activation of NAD(P)H oxidase activity|up regulation of NAD(P)H oxidase activity|upregulation of NAD(P)H oxidase activity biological_process owl:Class GO:0005272 biolink:NamedThing sodium channel activity Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. tmpzr1t_l9r_go_relaxed.owl Reactome:R-HSA-3295580|Reactome:R-HSA-2730664 molecular_function owl:Class GO:0005261 biolink:NamedThing cation channel activity Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. tmpzr1t_l9r_go_relaxed.owl non-selective cation channel activity|cation diffusion facilitator activity Reactome:R-HSA-426223|Reactome:R-HSA-169683|Reactome:R-HSA-1168376|Reactome:R-HSA-2089943|Reactome:R-HSA-4420052|Reactome:R-HSA-1296043 GO:0015281|GO:0015338 molecular_function owl:Class GO:0060520 biolink:NamedThing activation of prostate induction by androgen receptor signaling pathway Any series of molecular signals generated as a consequence of an androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland. tmpzr1t_l9r_go_relaxed.owl activation of prostate induction by androgen receptor signalling pathway biological_process owl:Class GO:0010647 biolink:NamedThing positive regulation of cell communication Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0050592 biolink:NamedThing 4-hydroxyphenylacetaldehyde oxime monooxygenase activity Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+). tmpzr1t_l9r_go_relaxed.owl (Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity|4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity|NADPH-cytochrome P450 reductase (CYP71E1)|cytochrome P450-II-dependent monooxygenase activity|cytochrome P450II-dependent monooxygenase activity|4-hydroxybenzeneacetaldehyde oxime monooxygenase activity|CYP71E1 activity EC:1.14.14.37|MetaCyc:1.14.13.68-RXN|KEGG_REACTION:R05728|RHEA:18401 molecular_function owl:Class GO:0060557 biolink:NamedThing positive regulation of vitamin D biosynthetic process Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). tmpzr1t_l9r_go_relaxed.owl dph 2009-04-13T02:46:14Z biological_process owl:Class GO:0030436 biolink:NamedThing asexual sporulation The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi. tmpzr1t_l9r_go_relaxed.owl mitotic sporulation|asexual reproductive sporulation|mitotic spore formation|asexual spore formation biological_process owl:Class GO:0019954 biolink:NamedThing asexual reproduction The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process. tmpzr1t_l9r_go_relaxed.owl parthenogenesis Wikipedia:Asexual_reproduction biological_process owl:Class GO:0099008 biolink:NamedThing viral entry via permeabilization of inner membrane The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane. tmpzr1t_l9r_go_relaxed.owl viral penetration via permeabilization of host membrane VZ:985 biological_process owl:Class GO:0140267 biolink:NamedThing viral entry via permeabilization of host membrane The entry of a virus into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration capsid protein. Results in release of the virus contents into the host cell cytoplasm. tmpzr1t_l9r_go_relaxed.owl pg 2018-09-25T14:33:03Z biological_process owl:Class GO:1902078 biolink:NamedThing positive regulation of lateral motor column neuron migration Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration. tmpzr1t_l9r_go_relaxed.owl activation of lateral motor column neuron migration|up-regulation of lateral motor column neuron migration|upregulation of lateral motor column neuron migration|up regulation of lateral motor column neuron migration pr 2013-04-23T14:42:28Z biological_process owl:Class GO:1902076 biolink:NamedThing regulation of lateral motor column neuron migration Any process that modulates the frequency, rate or extent of lateral motor column neuron migration. tmpzr1t_l9r_go_relaxed.owl pr 2013-04-23T14:42:18Z biological_process owl:Class GO:0033262 biolink:NamedThing regulation of nuclear cell cycle DNA replication Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. tmpzr1t_l9r_go_relaxed.owl regulation of DNA replication involved in S-phase|regulation of DNA replication during S phase|regulation of DNA replication involved in S phase biological_process owl:Class GO:0035189 biolink:NamedThing Rb-E2F complex A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression. tmpzr1t_l9r_go_relaxed.owl retinoblastoma-E2F complex cellular_component owl:Class GO:0015885 biolink:NamedThing 5-formyltetrahydrofolate transport The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0006835 biolink:NamedThing dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl sodium:dicarboxylate transport GO:0006841 biological_process owl:Class GO:0071656 biolink:NamedThing negative regulation of granulocyte colony-stimulating factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor. tmpzr1t_l9r_go_relaxed.owl negative regulation of colony stimulating factor 3 (granulocyte) production|negative regulation of CSF3 production|negative regulation of filgrastim production|negative regulation of pluripoietin production|negative regulation of G-CSF production|negative regulation of granulocyte colony stimulating factor production|negative regulation of lenograstim production mah 2010-02-12T10:41:14Z biological_process owl:Class GO:1901257 biolink:NamedThing negative regulation of macrophage colony-stimulating factor production Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor production. tmpzr1t_l9r_go_relaxed.owl down regulation of M-CSF production|downregulation of M-CSF production|downregulation of macrophage colony-stimulating factor production|inhibition of macrophage colony-stimulating factor production|down-regulation of macrophage colony-stimulating factor production|down-regulation of M-CSF production|down regulation of macrophage colony-stimulating factor production|inhibition of M-CSF production|negative regulation of M-CSF production vk 2012-08-10T08:28:28Z biological_process owl:Class GO:1900714 biolink:NamedThing negative regulation of violaceol I biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of violaceol I biosynthetic process. tmpzr1t_l9r_go_relaxed.owl down regulation of violaceol I formation|down-regulation of violaceol I biosynthetic process|downregulation of violaceol I biosynthesis|down-regulation of violaceol I biosynthesis|downregulation of violaceol I biosynthetic process|inhibition of violaceol I anabolism|inhibition of violaceol I biosynthesis|downregulation of violaceol I formation|down-regulation of violaceol I anabolism|down regulation of violaceol I anabolism|downregulation of violaceol I anabolism|negative regulation of violaceol I anabolism|down regulation of violaceol I biosynthesis|negative regulation of violaceol I biosynthesis|down regulation of violaceol I biosynthetic process|negative regulation of violaceol I synthesis|down-regulation of violaceol I synthesis|inhibition of violaceol I biosynthetic process|inhibition of violaceol I formation|inhibition of violaceol I synthesis|negative regulation of violaceol I formation|down regulation of violaceol I synthesis|downregulation of violaceol I synthesis|down-regulation of violaceol I formation di 2012-05-22T05:04:33Z biological_process owl:Class GO:0048138 biolink:NamedThing germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0003006 biolink:NamedThing developmental process involved in reproduction A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. tmpzr1t_l9r_go_relaxed.owl puberty|reproductive developmental process biological_process owl:Class GO:0071263 biolink:NamedThing negative regulation of translational initiation in response to starvation Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment. tmpzr1t_l9r_go_relaxed.owl negative regulation of translational initiation in response to nutrient starvation|downregulation of translation initiation in response to starvation|down regulation of translation initiation in response to starvation|down-regulation of translation initiation in response to starvation|inhibition of translation initiation in response to starvation mah 2009-12-08T05:33:12Z biological_process owl:Class GO:0032057 biolink:NamedThing negative regulation of translational initiation in response to stress Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. tmpzr1t_l9r_go_relaxed.owl down-regulation of translation initiation in response to stress|downregulation of translation initiation in response to stress|inhibition of translation initiation in response to stress|down regulation of translation initiation in response to stress biological_process owl:Class GO:1901255 biolink:NamedThing nucleotide-excision repair involved in interstrand cross-link repair Any nucleotide-excision repair that is involved in interstrand cross-link repair. tmpzr1t_l9r_go_relaxed.owl NER involved in ICL repair|nucleotide-excision repair involved in ICL repair|NER involved in interstrand cross-link repair vw 2012-08-09T06:09:50Z biological_process owl:Class GO:0006289 biolink:NamedThing nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). tmpzr1t_l9r_go_relaxed.owl pyrimidine-dimer repair, DNA damage excision|intrastrand cross-link repair|NER Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. GO:0045001 biological_process owl:Class GO:0032707 biolink:NamedThing negative regulation of interleukin-23 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production. tmpzr1t_l9r_go_relaxed.owl negative regulation of interleukin-23 biosynthetic process|inhibition of interleukin-23 production|downregulation of interleukin-23 production|down-regulation of interleukin-23 production|negative regulation of IL-23 production|down regulation of interleukin-23 production GO:0045397 biological_process owl:Class GO:0032667 biolink:NamedThing regulation of interleukin-23 production Any process that modulates the frequency, rate, or extent of interleukin-23 production. tmpzr1t_l9r_go_relaxed.owl regulation of IL-23 production|regulation of interleukin-23 synthesis|regulation of interleukin-23 biosynthesis|regulation of IL-23 biosynthetic process|regulation of interleukin-23 biosynthetic process|regulation of interleukin-23 anabolism|regulation of interleukin-23 formation GO:0045396 biological_process owl:Class GO:1901264 biolink:NamedThing carbohydrate derivative transport The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl bf 2012-08-16T14:51:22Z biological_process owl:Class GO:0090042 biolink:NamedThing tubulin deacetylation The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. tmpzr1t_l9r_go_relaxed.owl tb 2009-08-03T11:50:47Z biological_process owl:Class GO:0006476 biolink:NamedThing protein deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. tmpzr1t_l9r_go_relaxed.owl protein amino acid deacetylation biological_process owl:Class GO:1900258 biolink:NamedThing positive regulation of beta1-adrenergic receptor activity Any process that activates or increases the frequency, rate or extent of beta1-adrenergic receptor activity. tmpzr1t_l9r_go_relaxed.owl up-regulation of beta1-adrenergic receptor activity|positive regulation of beta1 adrenoceptor|up regulation of beta1-adrenergic receptor activity|upregulation of beta1-adrenergic receptor activity|up regulation of beta1 adrenoceptor|activation of beta1 adrenoceptor|up-regulation of beta1 adrenoceptor|activation of beta1-adrenergic receptor activity|upregulation of beta1 adrenoceptor tb 2012-04-03T10:59:49Z biological_process owl:Class GO:0150127 biolink:NamedThing regulation of interleukin-33 production Any process that modulates the frequency, rate or extent of interleukin-33 production. tmpzr1t_l9r_go_relaxed.owl regulation of interleukin-33 secretion|regulation of interleukin-33 biosynthetic process bc 2019-12-03T05:54:03Z GO:0150130|GO:0150123 biological_process owl:Class GO:0010629 biolink:NamedThing negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. tmpzr1t_l9r_go_relaxed.owl gene silencing This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. biological_process owl:Class GO:0071480 biolink:NamedThing cellular response to gamma radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. tmpzr1t_l9r_go_relaxed.owl cellular response to gamma ray|cellular response to gamma-ray photon mah 2009-12-18T02:00:50Z biological_process owl:Class GO:0010332 biolink:NamedThing response to gamma radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. tmpzr1t_l9r_go_relaxed.owl response to gamma ray|response to gamma-ray photon biological_process owl:Class GO:1900606 biolink:NamedThing tensidol B metabolic process The chemical reactions and pathways involving tensidol B. tmpzr1t_l9r_go_relaxed.owl tensidol B metabolism di 2012-05-15T06:58:21Z biological_process owl:Class GO:0044149 biolink:NamedThing positive regulation of formation of structure involved in a symbiotic process Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. tmpzr1t_l9r_go_relaxed.owl positive regulation of development of symbiont involved in interaction with host|positive regulation of development of symbiont during interaction with host https://github.com/geneontology/go-ontology/issues/20305 This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'. jl 2009-08-06T02:20:55Z biological_process owl:Class GO:0048518 biolink:NamedThing positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. tmpzr1t_l9r_go_relaxed.owl upregulation of biological process|positive regulation of physiological process|up regulation of biological process|activation of biological process|up-regulation of biological process|stimulation of biological process GO:0043119 biological_process owl:Class GO:0052765 biolink:NamedThing reduced coenzyme F420 oxidase activity Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O. tmpzr1t_l9r_go_relaxed.owl F420H2:oxygen oxidoreductase activity|coenzyme F420H2 oxidase activity|F420H2 oxidase activity ai 2011-09-29T04:33:54Z molecular_function owl:Class GO:0033634 biolink:NamedThing positive regulation of cell-cell adhesion mediated by integrin Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin. tmpzr1t_l9r_go_relaxed.owl positive regulation of cell-cell adhesion mediated by integrin complex biological_process owl:Class GO:0022409 biolink:NamedThing positive regulation of cell-cell adhesion Any process that activates or increases the rate or extent of cell adhesion to another cell. tmpzr1t_l9r_go_relaxed.owl upregulation of cell-cell adhesion|stimulation of cell-cell adhesion|up regulation of cell-cell adhesion|up-regulation of cell-cell adhesion|activation of cell-cell adhesion biological_process owl:Class GO:0014838 biolink:NamedThing myoblast fate specification involved in skeletal muscle regeneration The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0048626 biolink:NamedThing myoblast fate specification The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0150200 biolink:NamedThing regulation of transport across blood-brain barrier Any process that modulates the frequency, rate or extent of transport across the blood-brain barrier. tmpzr1t_l9r_go_relaxed.owl bc 2020-03-26T19:22:26Z biological_process owl:Class GO:2001285 biolink:NamedThing negative regulation of BMP secretion Any process that stops, prevents or reduces the frequency, rate or extent of BMP secretion. tmpzr1t_l9r_go_relaxed.owl negative regulation of BMP protein secretion|negative regulation of bone morphogenetic protein secretion bf 2011-12-15T02:15:36Z biological_process owl:Class GO:0023057 biolink:NamedThing negative regulation of signaling Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. tmpzr1t_l9r_go_relaxed.owl negative regulation of signaling process|negative regulation of signalling process 2010-02-16T09:30:50Z biological_process owl:Class GO:0010903 biolink:NamedThing negative regulation of very-low-density lipoprotein particle remodeling Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. tmpzr1t_l9r_go_relaxed.owl negative regulation of VLDL remodeling biological_process owl:Class GO:0010901 biolink:NamedThing regulation of very-low-density lipoprotein particle remodeling Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. tmpzr1t_l9r_go_relaxed.owl regulation of VLDL remodeling biological_process owl:Class GO:0061358 biolink:NamedThing negative regulation of Wnt protein secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell. tmpzr1t_l9r_go_relaxed.owl dph 2010-10-08T01:15:15Z biological_process owl:Class GO:0018905 biolink:NamedThing dimethyl ether metabolic process The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications. tmpzr1t_l9r_go_relaxed.owl dimethyl ether metabolism|methyl ether metabolism|methyl ether metabolic process UM-BBD_pathwayID:dme biological_process owl:Class GO:0006805 biolink:NamedThing xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. tmpzr1t_l9r_go_relaxed.owl drug metabolic process|drug metabolism|xenobiotic metabolism https://github.com/geneontology/go-ontology/issues/19460 Wikipedia:Drug_metabolism|Wikipedia:Xenobiotic_metabolism GO:0017144 biological_process owl:Class GO:0032665 biolink:NamedThing regulation of interleukin-21 production Any process that modulates the frequency, rate, or extent of interleukin-21 production. tmpzr1t_l9r_go_relaxed.owl regulation of interleukin-21 biosynthetic process|regulation of IL-21 production GO:0045390 biological_process owl:Class GO:0044610 biolink:NamedThing FMN transmembrane transporter activity Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl flavine mononucleotide transmembrane transporter activity jl 2012-05-30T03:09:19Z molecular_function owl:Class GO:1901505 biolink:NamedThing carbohydrate derivative transmembrane transporter activity Enables the transfer of carbohydrate derivative from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl carbohydrate derivative transporter activity pr 2012-10-17T10:31:22Z molecular_function owl:Class GO:0060340 biolink:NamedThing positive regulation of type I interferon-mediated signaling pathway Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. tmpzr1t_l9r_go_relaxed.owl positive regulation of type I interferon-mediated signalling pathway biological_process owl:Class GO:0045089 biolink:NamedThing positive regulation of innate immune response Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. tmpzr1t_l9r_go_relaxed.owl stimulation of innate immune response|upregulation of innate immune response|up-regulation of innate immune response|up regulation of innate immune response biological_process owl:Class GO:1905920 biolink:NamedThing positive regulation of CoA-transferase activity Any process that activates or increases the frequency, rate or extent of CoA-transferase activity. tmpzr1t_l9r_go_relaxed.owl activation of CoA-transferase activity|upregulation of CoA-transferase activity|up regulation of CoA-transferase activity|up-regulation of CoA-transferase activity bc 2017-02-08T13:01:04Z biological_process owl:Class GO:1905918 biolink:NamedThing regulation of CoA-transferase activity Any process that modulates the frequency, rate or extent of CoA-transferase activity. tmpzr1t_l9r_go_relaxed.owl bc 2017-02-08T13:00:48Z biological_process owl:Class GO:0035807 biolink:NamedThing positive regulation of blood coagulation in other organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. tmpzr1t_l9r_go_relaxed.owl positive regulation of blood clotting in other organism|positive regulation by organism of blood clotting in other organism|positive regulation by organism of blood coagulation in other organism bf 2011-04-20T11:43:37Z biological_process owl:Class GO:0035806 biolink:NamedThing modulation of blood coagulation in other organism Any process in which an organism modulates the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. tmpzr1t_l9r_go_relaxed.owl modulation by organism of blood clotting in other organism|regulation of blood coagulation in other organism|regulation by organism of blood clotting in other organism|regulation of blood clotting in other organism|modulation by organism of blood coagulation in other organism bf 2011-04-20T11:38:49Z biological_process owl:Class GO:0048215 biolink:NamedThing positive regulation of Golgi vesicle fusion to target membrane Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane. tmpzr1t_l9r_go_relaxed.owl up-regulation of Golgi vesicle fusion to target membrane|stimulation of Golgi vesicle fusion to target membrane|activation of Golgi vesicle fusion to target membrane|up regulation of Golgi vesicle fusion to target membrane|upregulation of Golgi vesicle fusion to target membrane biological_process owl:Class GO:0031340 biolink:NamedThing positive regulation of vesicle fusion Any process that activates or increases the frequency, rate or extent of vesicle fusion. tmpzr1t_l9r_go_relaxed.owl activation of vesicle fusion|up regulation of vesicle fusion|upregulation of vesicle fusion|stimulation of vesicle fusion|up-regulation of vesicle fusion biological_process owl:Class GO:0052702 biolink:NamedThing cellular modified histidine catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. tmpzr1t_l9r_go_relaxed.owl cellular histidine derivative catabolic process|histidine derivative catabolic process|cellular modified histidine degradation|modified histidine catabolic process|cellular histidine derivative degradation|modified histidine catabolism|cellular histidine derivative breakdown|cellular modified histidine catabolism|cellular modified histidine breakdown|cellular histidine derivative catabolism ai 2011-08-01T03:48:41Z biological_process owl:Class GO:0071547 biolink:NamedThing piP-body A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway. tmpzr1t_l9r_go_relaxed.owl mah 2010-01-12T05:47:47Z cellular_component owl:Class GO:0019095 biolink:NamedThing pole plasm mitochondrial rRNA localization Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. tmpzr1t_l9r_go_relaxed.owl establishment and maintenance of mitochondrial rRNA localization in pole plasm|pole plasm mitochondrial rRNA localisation|oocyte pole plasm mitochondrial rRNA localization GO:0048117 biological_process owl:Class GO:0007316 biolink:NamedThing pole plasm RNA localization Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. tmpzr1t_l9r_go_relaxed.owl oocyte pole plasm RNA localization|establishment and maintenance of pole plasm RNA localization|pole plasm RNA localisation GO:0048116 biological_process owl:Class GO:0102956 biolink:NamedThing UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP. tmpzr1t_l9r_go_relaxed.owl MetaCyc:RXN-92|RHEA:57712 molecular_function owl:Class GO:1905837 biolink:NamedThing cellular response to triterpenoid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus. tmpzr1t_l9r_go_relaxed.owl sl 2017-01-17T19:37:44Z biological_process owl:Class GO:0071396 biolink:NamedThing cellular response to lipid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2009-12-11T04:37:10Z biological_process owl:Class GO:0044062 biolink:NamedThing regulation of excretion Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0031078 biolink:NamedThing histone deacetylase activity (H3-K14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0004407 biolink:NamedThing histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/22295 Reactome:R-HSA-3782637|Reactome:R-HSA-2545203|Reactome:R-HSA-3782655|Reactome:R-HSA-433672|RHEA:58196|Reactome:R-HSA-3777129|Reactome:R-HSA-6805650|Reactome:R-HSA-3769447|Reactome:R-HSA-2545253|MetaCyc:3.5.1.98-RXN|EC:3.5.1.98|Reactome:R-HSA-427514 molecular_function owl:Class GO:1903454 biolink:NamedThing regulation of androst-4-ene-3,17-dione biosynthetic process Any process that modulates the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of androstenedione biosynthetic process|regulation of androst-4-ene-3,17-dione biosynthesis|regulation of androst-4-ene-3,17-dione synthesis|regulation of androst-4-ene-3,17-dione formation|regulation of androst-4-ene-3,17-dione anabolism mr 2014-09-22T14:36:50Z biological_process owl:Class GO:0010566 biolink:NamedThing regulation of ketone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1904263 biolink:NamedThing positive regulation of TORC1 signaling Any process that activates or increases the frequency, rate or extent of TORC1 signaling. tmpzr1t_l9r_go_relaxed.owl up regulation of TORC1 signal transduction|up-regulation of TORC1 signaling|activation of TORC1 signal transduction|activation of TORC1 signaling|positive regulation of TORC1 signal transduction|upregulation of TORC1 signal transduction|upregulation of TORC1 signaling|up-regulation of TORC1 signal transduction|up regulation of TORC1 signaling lb 2015-05-27T13:13:10Z biological_process owl:Class GO:0032008 biolink:NamedThing positive regulation of TOR signaling Any process that activates or increases the frequency, rate or extent of TOR signaling. tmpzr1t_l9r_go_relaxed.owl activation of TOR signaling pathway|positive regulation of TOR signaling cascade|up-regulation of TOR signaling pathway|stimulation of TOR signaling pathway|upregulation of TOR signaling pathway|positive regulation of target of rapamycin signalling pathway|up regulation of TOR signaling pathway|positive regulation of TOR signaling pathway|positive regulation of target of rapamycin signaling pathway|positive regulation of TOR signalling pathway biological_process owl:Class GO:0061546 biolink:NamedThing tyramine secretion, neurotransmission The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter. tmpzr1t_l9r_go_relaxed.owl dph 2013-06-25T09:16:47Z biological_process owl:Class GO:0061532 biolink:NamedThing primary amine secretion, neurotransmission The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter. tmpzr1t_l9r_go_relaxed.owl dph 2013-06-21T15:57:12Z biological_process owl:Class GO:0050908 biolink:NamedThing detection of light stimulus involved in visual perception The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. tmpzr1t_l9r_go_relaxed.owl visual perception, sensory transduction of light stimulus|sensory transduction of light during visual perception|sensory transduction of light stimulus during visual perception|visual perception, sensory transduction during perception of light|visual perception, detection of light stimulus|sensory detection of light during visual perception|sensory detection of light stimulus during visual perception biological_process owl:Class GO:0050962 biolink:NamedThing detection of light stimulus involved in sensory perception The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. tmpzr1t_l9r_go_relaxed.owl sensory perception, sensory detection of light stimulus|sensory transduction of light stimulus during sensory perception|sensory detection of light stimulus during sensory perception|sensory perception, sensory transduction of light stimulus|sensory transduction of light stimulus|sensory detection of light stimulus biological_process owl:Class GO:0051169 biolink:NamedThing nuclear transport The directed movement of substances into, out of, or within the nucleus. tmpzr1t_l9r_go_relaxed.owl nucleus transport Wikipedia:Nuclear_transport biological_process owl:Class GO:0035157 biolink:NamedThing negative regulation of fusion cell fate specification Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates. tmpzr1t_l9r_go_relaxed.owl downregulation of fusion cell fate specification|inhibition of fusion cell fate specification|down regulation of fusion cell fate specification|down-regulation of fusion cell fate specification biological_process owl:Class GO:0009996 biolink:NamedThing negative regulation of cell fate specification Any process that restricts, stops or prevents a cell from adopting a specific cell fate. tmpzr1t_l9r_go_relaxed.owl suppression of cell fate|down regulation of cell fate specification|down-regulation of cell fate specification|downregulation of cell fate specification|inhibition of cell fate specification biological_process owl:Class GO:0071203 biolink:NamedThing WASH complex A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. tmpzr1t_l9r_go_relaxed.owl mah 2009-11-25T11:01:33Z cellular_component owl:Class GO:0061013 biolink:NamedThing regulation of mRNA catabolic process Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. tmpzr1t_l9r_go_relaxed.owl regulation of mRNA decay dph 2010-01-29T01:48:10Z biological_process owl:Class GO:1903311 biolink:NamedThing regulation of mRNA metabolic process Any process that modulates the frequency, rate or extent of mRNA metabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of mRNA metabolism vw 2014-08-18T11:52:26Z biological_process owl:Class GO:1904527 biolink:NamedThing negative regulation of microtubule binding Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding. tmpzr1t_l9r_go_relaxed.owl down-regulation of microtubule/chromatin interaction|inhibition of microtubule severing activity|downregulation of microtubule severing activity|inhibition of microtubule binding|down regulation of microtubule severing activity|down regulation of microtubule/chromatin interaction|down-regulation of microtubule severing activity|down regulation of microtubule binding|negative regulation of microtubule/chromatin interaction|inhibition of microtubule/chromatin interaction|down-regulation of microtubule binding|downregulation of microtubule binding|downregulation of microtubule/chromatin interaction|negative regulation of microtubule severing activity als 2015-07-30T10:32:29Z biological_process owl:Class GO:1904526 biolink:NamedThing regulation of microtubule binding Any process that modulates the frequency, rate or extent of microtubule binding. tmpzr1t_l9r_go_relaxed.owl regulation of microtubule/chromatin interaction|regulation of microtubule severing activity als 2015-07-30T10:32:13Z biological_process owl:Class GO:0018417 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. tmpzr1t_l9r_go_relaxed.owl iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide RESID:AA0293 biological_process owl:Class GO:0018200 biolink:NamedThing peptidyl-glutamic acid modification The modification of peptidyl-glutamic acid. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0048928 biolink:NamedThing posterior lateral line ganglion neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0048891 biolink:NamedThing lateral line ganglion neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron. tmpzr1t_l9r_go_relaxed.owl gLL neuron differentiation biological_process owl:Class GO:0075289 biolink:NamedThing aplanospore formation The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0034300 biolink:NamedThing sporangiospore formation The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:2000303 biolink:NamedThing regulation of ceramide biosynthetic process Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process. tmpzr1t_l9r_go_relaxed.owl regulation of ceramide formation|regulation of ceramide anabolism|regulation of ceramide synthesis|regulation of ceramide biosynthesis dph 2011-01-04T02:37:12Z biological_process owl:Class GO:2000899 biolink:NamedThing xyloglucan catabolic process The chemical reactions and pathways resulting in the breakdown of a xyloglucan. tmpzr1t_l9r_go_relaxed.owl xyloglucan catabolism jl 2011-07-28T02:52:33Z biological_process owl:Class GO:0010411 biolink:NamedThing xyloglucan metabolic process The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants. tmpzr1t_l9r_go_relaxed.owl xyloglucan metabolism biological_process owl:Class GO:1905494 biolink:NamedThing negative regulation of G-quadruplex DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA binding. tmpzr1t_l9r_go_relaxed.owl down-regulation of G-quartet DNA binding|inhibition of G-quartet DNA binding|negative regulation of G-DNA binding|inhibition of G-DNA binding|inhibition of tetraplex DNA binding|downregulation of quadruplex DNA binding|down regulation of tetraplex DNA binding|down-regulation of G-quadruplex DNA binding|downregulation of G-DNA binding|down-regulation of quadruplex DNA binding|down regulation of G-DNA binding|down regulation of quadruplex DNA binding|negative regulation of quadruplex DNA binding|down regulation of G quadruplex DNA binding|down-regulation of G-DNA binding|negative regulation of G-quartet DNA binding|inhibition of quadruplex DNA binding|inhibition of G quartet DNA binding|down regulation of G-quartet DNA binding|negative regulation of G quadruplex DNA binding|down-regulation of tetraplex DNA binding|downregulation of G-quartet DNA binding|negative regulation of tetraplex DNA binding|downregulation of tetraplex DNA binding|negative regulation of G quartet DNA binding|inhibition of G quadruplex DNA binding|downregulation of G-quadruplex DNA binding|down regulation of G-quadruplex DNA binding|downregulation of G quadruplex DNA binding|inhibition of G-quadruplex DNA binding|down-regulation of G quadruplex DNA binding|down regulation of G quartet DNA binding|down-regulation of G quartet DNA binding|downregulation of G quartet DNA binding ans 2016-09-26T14:53:29Z biological_process owl:Class GO:0010851 biolink:NamedThing cyclase regulator activity Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0030234 biolink:NamedThing enzyme regulator activity Binds to and modulates the activity of an enzyme. tmpzr1t_l9r_go_relaxed.owl catalytic regulator activity|enzyme modulator|metalloenzyme regulator activity This term should only be used in cases when the regulator directly interacts with the enzyme. GO:0010576 molecular_function owl:Class GO:0048094 biolink:NamedThing male pigmentation Establishment of a pattern of pigment in males. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0048071 biolink:NamedThing sex-specific pigmentation Establishment of a pattern of pigment in one sex that is not observed in the other sex. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0030096 biolink:NamedThing plasma membrane-derived thylakoid photosystem II A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone. tmpzr1t_l9r_go_relaxed.owl plasma membrane photosystem II cellular_component owl:Class GO:0072755 biolink:NamedThing cellular response to benomyl Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus. tmpzr1t_l9r_go_relaxed.owl mah 2012-11-07T12:06:58Z biological_process owl:Class GO:0010527 biolink:NamedThing positive regulation of transposition, RNA-mediated Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0010530 biolink:NamedThing positive regulation of transposition Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0031139 biolink:NamedThing positive regulation of conjugation with cellular fusion Any process that increases the rate or frequency of conjugation with cellular fusion. tmpzr1t_l9r_go_relaxed.owl activation of conjugation with cellular fusion|stimulation of conjugation with cellular fusion|upregulation of conjugation with cellular fusion|up-regulation of conjugation with cellular fusion|up regulation of conjugation with cellular fusion biological_process owl:Class GO:0031136 biolink:NamedThing positive regulation of conjugation Any process that increases the rate or frequency of conjugation. tmpzr1t_l9r_go_relaxed.owl activation of conjugation|upregulation of conjugation|stimulation of conjugation|up regulation of conjugation|up-regulation of conjugation biological_process owl:Class GO:0090211 biolink:NamedThing positive regulation of establishment of blood-brain barrier Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain. tmpzr1t_l9r_go_relaxed.owl positive regulation of establishment of BBB tb 2009-12-23T12:15:53Z biological_process owl:Class GO:0051240 biolink:NamedThing positive regulation of multicellular organismal process Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. tmpzr1t_l9r_go_relaxed.owl up-regulation of multicellular organismal process|activation of multicellular organismal process|stimulation of multicellular organismal process|up regulation of multicellular organismal process|upregulation of multicellular organismal process biological_process owl:Class GO:0140454 biolink:NamedThing protein aggregate center assembly The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. tmpzr1t_l9r_go_relaxed.owl protein aggregate centre assembly|PAC assembly|protein aggregate center formation https://github.com/geneontology/go-ontology/issues/19172 pg 2020-04-20T15:43:52Z biological_process owl:Class GO:0022607 biolink:NamedThing cellular component assembly The aggregation, arrangement and bonding together of a cellular component. tmpzr1t_l9r_go_relaxed.owl cell structure assembly|cellular component assembly at cellular level GO:0071844 biological_process owl:Class GO:0048088 biolink:NamedThing regulation of male pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0062093 biolink:NamedThing lysophagy The selective autophagy process in which a damaged lysosome is degraded by macroautophagy. tmpzr1t_l9r_go_relaxed.owl dph 2018-11-20T16:47:11Z biological_process owl:Class GO:0061912 biolink:NamedThing selective autophagy The macroautophagy process in which specific structures are targeted by the autophagy process. tmpzr1t_l9r_go_relaxed.owl dph 2017-07-07T17:27:37Z biological_process owl:Class GO:0042100 biolink:NamedThing B cell proliferation The expansion of a B cell population by cell division. Follows B cell activation. tmpzr1t_l9r_go_relaxed.owl B lymphocyte proliferation|B-lymphocyte proliferation|B-cell proliferation GO:0042114 biological_process owl:Class GO:0042113 biolink:NamedThing B cell activation The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. tmpzr1t_l9r_go_relaxed.owl B-cell activation|B lymphocyte activation|B-lymphocyte activation biological_process owl:Class GO:0015067 biolink:NamedThing amidinotransferase activity Catalysis of the reversible transfer of an amidino group to an acceptor. tmpzr1t_l9r_go_relaxed.owl transamidinase activity EC:2.1.4.- molecular_function owl:Class GO:0016741 biolink:NamedThing transferase activity, transferring one-carbon groups Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). tmpzr1t_l9r_go_relaxed.owl methyltransferase activity https://github.com/geneontology/go-ontology/issues/20486 EC:2.1.-.- molecular_function owl:Class GO:1901218 biolink:NamedThing negative regulation of holin activity Any process that stops, prevents or reduces the frequency, rate or extent of holin activity. tmpzr1t_l9r_go_relaxed.owl inhibition of holin activity|down-regulation of holin activity|downregulation of holin activity|antiholin activity|down regulation of holin activity|phage antiholin bf 2012-08-06T10:48:00Z biological_process owl:Class GO:0032410 biolink:NamedThing negative regulation of transporter activity Any process that stops or reduces the activity of a transporter. tmpzr1t_l9r_go_relaxed.owl downregulation of transporter activity|down-regulation of transporter activity|down regulation of transporter activity|inhibition of transporter activity biological_process owl:Class GO:0044634 biolink:NamedThing negative regulation of complement activation, alternative pathway in other organism Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism. tmpzr1t_l9r_go_relaxed.owl jl 2012-07-05T04:32:55Z biological_process owl:Class GO:0044633 biolink:NamedThing modulation of complement activation, alternative pathway in other organism A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism. tmpzr1t_l9r_go_relaxed.owl regulation of complement activation, alternative pathway in other organism jl 2012-07-05T04:24:08Z biological_process owl:Class GO:0061981 biolink:NamedThing 3-hydroxykynureninase activity Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. tmpzr1t_l9r_go_relaxed.owl RHEA:25143 dph 2018-02-14T16:12:49Z molecular_function owl:Class GO:0045834 biolink:NamedThing positive regulation of lipid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. tmpzr1t_l9r_go_relaxed.owl activation of lipid metabolic process|up-regulation of lipid metabolic process|up regulation of lipid metabolic process|positive regulation of lipid metabolism|stimulation of lipid metabolic process|upregulation of lipid metabolic process biological_process owl:Class GO:0052751 biolink:NamedThing GDP-mannose hydrolase activity Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate. tmpzr1t_l9r_go_relaxed.owl GDP-mannose pyrophosphatase activity ai 2011-09-21T04:11:30Z molecular_function owl:Class GO:0062043 biolink:NamedThing positive regulation of cardiac epithelial to mesenchymal transition Any process that starts or increases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. tmpzr1t_l9r_go_relaxed.owl dph 2018-05-10T18:15:54Z biological_process owl:Class GO:1901940 biolink:NamedThing (-)-exo-alpha-bergamotene biosynthetic process The chemical reactions and pathways resulting in the formation of (-)-exo-alpha-bergamotene. tmpzr1t_l9r_go_relaxed.owl (-)-exo-alpha-bergamotene synthesis|(-)-exo-alpha-bergamotene biosynthesis|(-)-exo-alpha-bergamotene anabolism|(-)-exo-alpha-bergamotene formation ms 2013-02-18T14:55:32Z biological_process owl:Class GO:0034603 biolink:NamedThing pyruvate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0004738 biolink:NamedThing pyruvate dehydrogenase activity Catalysis of the oxidative decarboxylation of pyruvate. tmpzr1t_l9r_go_relaxed.owl pyruvic acid dehydrogenase activity|pyruvic dehydrogenase activity MetaCyc:PYRUVOXID-RXN|MetaCyc:RXN0-1134|Reactome:R-HSA-71397 molecular_function owl:Class GO:0019335 biolink:NamedThing 3-methylquinoline catabolic process The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring. tmpzr1t_l9r_go_relaxed.owl 3-methylquinoline degradation|3-methylquinoline breakdown|3-methylquinoline catabolism MetaCyc:PWY-721 biological_process owl:Class GO:0006216 biolink:NamedThing cytidine catabolic process The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside. tmpzr1t_l9r_go_relaxed.owl cytidine catabolism|cytidine breakdown|cytidine degradation biological_process owl:Class GO:0046087 biolink:NamedThing cytidine metabolic process The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside. tmpzr1t_l9r_go_relaxed.owl cytidine metabolism biological_process owl:Class GO:0015931 biolink:NamedThing nucleobase-containing compound transport The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl nucleobase, nucleoside, nucleotide and nucleic acid transport biological_process owl:Class GO:0071705 biolink:NamedThing nitrogen compound transport The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl mah 2010-03-08T03:56:28Z biological_process owl:Class GO:0090381 biolink:NamedThing regulation of heart induction Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart. tmpzr1t_l9r_go_relaxed.owl tb 2010-10-04T10:23:43Z biological_process owl:Class GO:0033088 biolink:NamedThing negative regulation of immature T cell proliferation in thymus Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus. tmpzr1t_l9r_go_relaxed.owl negative regulation of thymocyte proliferation|negative regulation of thymic T cell proliferation|negative regulation of thymocyte cell proliferation biological_process owl:Class GO:0033087 biolink:NamedThing negative regulation of immature T cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:2000424 biolink:NamedThing positive regulation of eosinophil chemotaxis Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis. tmpzr1t_l9r_go_relaxed.owl bf 2011-02-24T01:17:35Z biological_process owl:Class GO:2000422 biolink:NamedThing regulation of eosinophil chemotaxis Any process that modulates the frequency, rate or extent of eosinophil chemotaxis. tmpzr1t_l9r_go_relaxed.owl bf 2011-02-24T01:16:44Z biological_process owl:Class GO:0042198 biolink:NamedThing nylon metabolic process The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids. tmpzr1t_l9r_go_relaxed.owl nylon metabolism biological_process owl:Class GO:0000758 biolink:NamedThing agglutination involved in conjugation with mutual genetic exchange The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation without cellular fusion of a unicellular organism. tmpzr1t_l9r_go_relaxed.owl sexual flocculation|agglutination involved in conjugation without cellular fusion biological_process owl:Class GO:0000771 biolink:NamedThing agglutination involved in conjugation The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1903299 biolink:NamedThing regulation of hexokinase activity Any process that modulates the frequency, rate or extent of hexokinase activity. tmpzr1t_l9r_go_relaxed.owl regulation of hexokinase (phosphorylating)|regulation of hexokinase D|regulation of ATP-dependent hexokinase activity|regulation of hexokinase type III activity|regulation of hexokinase type IV glucokinase activity|regulation of hexokinase type II activity|regulation of hexokinase type IV|regulation of hexokinase type IV (glucokinase) activity|regulation of glucose ATP phosphotransferase activity|regulation of hexokinase type I activity|regulation of ATP:D-hexose 6-phosphotransferase activity mr 2014-08-15T23:17:53Z biological_process owl:Class GO:0043549 biolink:NamedThing regulation of kinase activity Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0060376 biolink:NamedThing positive regulation of mast cell differentiation Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0060375 biolink:NamedThing regulation of mast cell differentiation Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1900070 biolink:NamedThing negative regulation of cellular hyperosmotic salinity response Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response. tmpzr1t_l9r_go_relaxed.owl inhibition of cellular response to hyperosmotic salt stress|inhibition of cellular hyperosmotic salinity response|down-regulation of cellular response to hyperosmotic salt stress|downregulation of cellular response to hyperosmotic salt stress|down-regulation of cellular hyperosmotic salinity response|negative regulation of cellular response to hyperosmotic salt stress|down regulation of cellular hyperosmotic salinity response|downregulation of cellular hyperosmotic salinity response|down regulation of cellular response to hyperosmotic salt stress pr 2012-01-26T02:45:43Z biological_process owl:Class GO:1901001 biolink:NamedThing negative regulation of response to salt stress Any process that stops, prevents or reduces the frequency, rate or extent of response to salt stress. tmpzr1t_l9r_go_relaxed.owl downregulation of response to ionic osmotic stress|inhibition of response to ionic osmotic stress|inhibition of response to salt stress|downregulation of salinity response|down-regulation of response to ionic osmotic stress|down regulation of response to salt stress|downregulation of response to salt stress|negative regulation of response to ionic osmotic stress|down-regulation of response to salt stress|down regulation of salinity response|down regulation of response to ionic osmotic stress|inhibition of salinity response|negative regulation of salinity response|down-regulation of salinity response dhl 2012-06-14T05:41:43Z biological_process owl:Class GO:1903109 biolink:NamedThing positive regulation of mitochondrial transcription Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion. tmpzr1t_l9r_go_relaxed.owl up regulation of mitochondrial transcription|activation of transcription from mitochondrial promoter|upregulation of transcription from mitochondrial promoter|upregulation of mitochondrial transcription|up-regulation of transcription from mitochondrial promoter|activation of mitochondrial transcription|up-regulation of mitochondrial transcription|positive regulation of transcription from mitochondrial promoter|up regulation of transcription from mitochondrial promoter al 2014-06-09T11:53:20Z biological_process owl:Class GO:1903108 biolink:NamedThing regulation of mitochondrial transcription Any process that modulates the frequency, rate or extent of transcription occuring in the mitochondrion. tmpzr1t_l9r_go_relaxed.owl regulation of transcription from mitochondrial promoter al 2014-06-09T11:53:14Z biological_process owl:Class GO:1903832 biolink:NamedThing regulation of cellular response to amino acid starvation Any process that modulates the frequency, rate or extent of cellular response to amino acid starvation. tmpzr1t_l9r_go_relaxed.owl rn 2015-01-21T18:44:28Z biological_process owl:Class GO:0061534 biolink:NamedThing gamma-aminobutyric acid secretion, neurotransmission The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter. tmpzr1t_l9r_go_relaxed.owl dph 2013-06-21T16:10:50Z biological_process owl:Class GO:0016987 biolink:NamedThing sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. tmpzr1t_l9r_go_relaxed.owl core DNA-dependent RNA polymerase binding promoter specificity activity|plastid sigma factor activity|bacterial sigma factor activity|promoter selection factor activity|DNA-dependent RNA polymerase promoter selection factor|sigma transcription factor https://github.com/geneontology/go-ontology/issues/14848|https://github.com/geneontology/go-ontology/issues/15587 krc 2010-08-11T04:12:24Z GO:0001053|GO:0000996 molecular_function owl:Class GO:0071226 biolink:NamedThing cellular response to molecule of fungal origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide. tmpzr1t_l9r_go_relaxed.owl cellular response to fungus associated molecule mah 2009-12-03T01:50:01Z biological_process owl:Class GO:0002238 biolink:NamedThing response to molecule of fungal origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide. tmpzr1t_l9r_go_relaxed.owl response to fungus associated molecule biological_process owl:Class GO:1900556 biolink:NamedThing emericellamide catabolic process The chemical reactions and pathways resulting in the breakdown of emericellamide. tmpzr1t_l9r_go_relaxed.owl emericellamide breakdown|emericellamide catabolism|emericellamide degradation di 2012-05-15T01:33:07Z biological_process owl:Class GO:1901335 biolink:NamedThing lactone catabolic process The chemical reactions and pathways resulting in the breakdown of lactone. tmpzr1t_l9r_go_relaxed.owl lactone catabolism|lactone breakdown|lactone degradation bf 2012-09-03T10:27:11Z biological_process owl:Class GO:0046512 biolink:NamedThing sphingosine biosynthetic process The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. tmpzr1t_l9r_go_relaxed.owl sphingosine anabolism|sphingosine biosynthesis|sphingosine formation|sphingosine synthesis biological_process owl:Class GO:0046520 biolink:NamedThing sphingoid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. tmpzr1t_l9r_go_relaxed.owl sphingoid anabolism|sphingoid synthesis|sphingoid biosynthesis|sphingoid formation biological_process owl:Class GO:0031382 biolink:NamedThing mating projection formation The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi. tmpzr1t_l9r_go_relaxed.owl shmooing|mating projection biogenesis|mating projection assembly biological_process owl:Class GO:0120031 biolink:NamedThing plasma membrane bounded cell projection assembly Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. tmpzr1t_l9r_go_relaxed.owl eupodium https://github.com/geneontology/go-ontology/issues/13298 krc 2017-04-24T23:56:08Z biological_process owl:Class GO:0004819 biolink:NamedThing glutamine-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). tmpzr1t_l9r_go_relaxed.owl glutamine-tRNA synthetase activity|glutaminyl-transfer RNA synthetase activity|glutaminyl ribonucleic acid|L-glutamine:tRNAGln ligase (AMP-forming)|GlnRS|glutaminyl-tRNA synthetase activity|glutaminyl-transfer ribonucleate synthetase activity|glutamine translase activity Reactome:R-HSA-380241|RHEA:20121|Reactome:R-HSA-379982|EC:6.1.1.18|MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN molecular_function owl:Class GO:0004788 biolink:NamedThing thiamine diphosphokinase activity Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. tmpzr1t_l9r_go_relaxed.owl thiamine pyrophosphokinase activity|thiamin:ATP pyrophosphotransferase activity|thiamin pyrophosphotransferase activity|thiamin diphosphokinase activity|ATP:thiamin pyrophosphotransferase activity|thiaminokinase activity|ATP:thiamine diphosphotransferase activity|TPTase activity|thiamin pyrophosphokinase activity RHEA:11576|MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN|Reactome:R-HSA-196761|EC:2.7.6.2 molecular_function owl:Class GO:0016778 biolink:NamedThing diphosphotransferase activity Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). tmpzr1t_l9r_go_relaxed.owl EC:2.7.6.- molecular_function owl:Class GO:0050810 biolink:NamedThing regulation of steroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. tmpzr1t_l9r_go_relaxed.owl regulation of steroid synthesis|regulation of steroid biosynthesis|regulation of steroid anabolism|regulation of steroid formation|regulation of steroidogenesis biological_process owl:Class GO:0046890 biolink:NamedThing regulation of lipid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. tmpzr1t_l9r_go_relaxed.owl regulation of lipid synthesis|regulation of lipid biosynthesis|regulation of lipid formation|regulation of lipid anabolism|regulation of lipogenesis biological_process owl:Class GO:0008517 biolink:NamedThing folic acid transmembrane transporter activity Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. tmpzr1t_l9r_go_relaxed.owl folate transporter activity|folic acid transporter activity|folate transmembrane transporter activity|vitamin B9 transporter activity|vitamin M transporter activity Reactome:R-HSA-200729|Reactome:R-HSA-200646|Reactome:R-HSA-200680|Reactome:R-HSA-200652|Reactome:R-HSA-200720 molecular_function owl:Class GO:0072349 biolink:NamedThing modified amino acid transmembrane transporter activity Enables the transfer of modified amino acids from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl amino acid derivative transmembrane transporter activity|modified amino acid transporter activity mah 2010-11-11T11:50:31Z molecular_function owl:Class GO:0035208 biolink:NamedThing positive regulation of hemocyte proliferation Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster. tmpzr1t_l9r_go_relaxed.owl positive regulation of arthropod blood cell proliferation|upregulation of hemocyte proliferation|up-regulation of hemocyte proliferation|stimulation of hemocyte proliferation|up regulation of hemocyte proliferation|activation of hemocyte proliferation biological_process owl:Class GO:0008284 biolink:NamedThing positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation. tmpzr1t_l9r_go_relaxed.owl up-regulation of cell proliferation|upregulation of cell proliferation|stimulation of cell proliferation|activation of cell proliferation|up regulation of cell proliferation|positive regulation of cell proliferation biological_process owl:Class GO:0090343 biolink:NamedThing positive regulation of cell aging Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. tmpzr1t_l9r_go_relaxed.owl tb 2010-06-02T10:12:37Z biological_process owl:Class GO:0010667 biolink:NamedThing negative regulation of cardiac muscle cell apoptotic process Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. tmpzr1t_l9r_go_relaxed.owl down regulation of cardiac muscle cell apoptosis|inhibition of cardiac muscle cell apoptosis|down-regulation of cardiac muscle cell apoptosis|negative regulation of cardiac muscle cell apoptosis|downregulation of cardiac muscle cell apoptosis biological_process owl:Class GO:0010664 biolink:NamedThing negative regulation of striated muscle cell apoptotic process Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. tmpzr1t_l9r_go_relaxed.owl down regulation of striated muscle cell apoptosis|inhibition of striated muscle cell apoptosis|negative regulation of striated muscle cell apoptosis|down-regulation of striated muscle cell apoptosis|downregulation of striated muscle cell apoptosis biological_process owl:Class GO:1905940 biolink:NamedThing negative regulation of gonad development Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. tmpzr1t_l9r_go_relaxed.owl down regulation of gonad development|negative regulation of gonadogenesis|downregulation of gonad development|down-regulation of gonad development|down-regulation of gonadogenesis|inhibition of gonad development|downregulation of gonadogenesis|inhibition of gonadogenesis|down regulation of gonadogenesis hbye 2017-02-09T17:01:59Z biological_process owl:Class GO:2000242 biolink:NamedThing negative regulation of reproductive process Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. tmpzr1t_l9r_go_relaxed.owl mah 2010-11-10T02:44:05Z biological_process owl:Class GO:1900767 biolink:NamedThing fonsecin metabolic process The chemical reactions and pathways involving fonsecin. tmpzr1t_l9r_go_relaxed.owl fonsecin metabolism di 2012-06-04T09:21:14Z biological_process owl:Class GO:0014841 biolink:NamedThing skeletal muscle satellite cell proliferation The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0014856 biolink:NamedThing skeletal muscle cell proliferation The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:1904405 biolink:NamedThing cellular response to formaldehyde Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus. tmpzr1t_l9r_go_relaxed.owl sl 2015-06-23T21:14:10Z biological_process owl:Class GO:0110096 biolink:NamedThing cellular response to aldehyde Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus. tmpzr1t_l9r_go_relaxed.owl kmv 2018-02-16T21:29:18Z biological_process owl:Class GO:1990953 biolink:NamedThing intramanchette transport The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments. tmpzr1t_l9r_go_relaxed.owl IMT krc 2016-05-11T00:17:56Z biological_process owl:Class GO:0098840 biolink:NamedThing protein transport along microtubule The directed movement of a protein along a microtubule, mediated by motor proteins. tmpzr1t_l9r_go_relaxed.owl microtubule-based protein transport biological_process owl:Class GO:0018062 biolink:NamedThing peptidyl-tryptophan succinylation The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan. tmpzr1t_l9r_go_relaxed.owl RESID:AA0130 biological_process owl:Class GO:0031365 biolink:NamedThing N-terminal protein amino acid modification The alteration of the N-terminal amino acid residue in a protein. tmpzr1t_l9r_go_relaxed.owl peptide or protein amino-terminal blocking|peptide/protein amino-terminal blocking GO:0018409 biological_process owl:Class GO:0009847 biolink:NamedThing spore germination The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall). tmpzr1t_l9r_go_relaxed.owl spore germination on or near host GO:0075005 biological_process owl:Class GO:0030154 biolink:NamedThing cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. tmpzr1t_l9r_go_relaxed.owl Wikipedia:Cellular_differentiation biological_process owl:Class GO:0090360 biolink:NamedThing platelet-derived growth factor production The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. tmpzr1t_l9r_go_relaxed.owl Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. tb 2010-07-12T10:32:27Z biological_process owl:Class GO:0001816 biolink:NamedThing cytokine production The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. tmpzr1t_l9r_go_relaxed.owl interferon production|cytokine metabolic process|cytokine secretion|interleukin production|cytokine biosynthetic process|interferon secretion|interleukin secretion https://github.com/geneontology/go-ontology/issues/19116 Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. GO:0042107|GO:0042089|GO:0050663|GO:0042032 biological_process owl:Class GO:0050382 biolink:NamedThing uracil-5-carboxylate decarboxylase activity Catalysis of the reaction: H(+) + uracil 5-carboxylate = CO(2) + uracil. tmpzr1t_l9r_go_relaxed.owl uracil-5-carboxylate carboxy-lyase (uracil-forming)|uracil-5-carboxylic acid decarboxylase activity|uracil-5-carboxylate carboxy-lyase activity EC:4.1.1.66|KEGG_REACTION:R00973|MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN|RHEA:17685 molecular_function owl:Class GO:0032764 biolink:NamedThing negative regulation of mast cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production. tmpzr1t_l9r_go_relaxed.owl down regulation of mast cell cytokine production|downregulation of mast cell cytokine production|inhibition of mast cell cytokine production|down-regulation of mast cell cytokine production biological_process owl:Class GO:0106279 biolink:NamedThing negative regulation of UDP-N-acetylglucosamine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process. tmpzr1t_l9r_go_relaxed.owl negative regulation of UDP-N-acetylglucosamine formation|negative regulation of UDP-N-acetylglucosamine synthesis|negative regulation of UDP-GlcNAc biosynthesis|negative regulation of UDP-N-acetylglucosamine biosynthesis|negative regulation of UDP-N-acetylglucosamine anabolism|negative regulation of UDP-GlcNAc biosynthetic process hjd 2020-07-09T17:26:06Z biological_process owl:Class GO:0010563 biolink:NamedThing negative regulation of phosphorus metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0047709 biolink:NamedThing bis(2-ethylhexyl)phthalate esterase activity Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H(2)O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+). tmpzr1t_l9r_go_relaxed.owl bis(2-ethylhexyl)phthalate acylhydrolase activity|DEHP esterase activity KEGG_REACTION:R04202|RHEA:15529|MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN|EC:3.1.1.60 molecular_function owl:Class GO:0052689 biolink:NamedThing carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond. tmpzr1t_l9r_go_relaxed.owl esterase A|serine esterase activity|ali-esterase activity|carboxylic acid esterase activity|procaine esterase activity|carboxylic esterase activity|carboxyesterase activity|carboxyl ester hydrolase activity|B-esterase activity|vitamin A esterase|cocaine esterase activity|nonspecific carboxylesterase activity|carboxylesterase activity|carboxylate esterase activity|esterase B|triacetin esterase|alpha-carboxylesterase activity Reactome:R-HSA-5693691|EC:3.1.1.1|Reactome:R-HSA-8937442|MetaCyc:CARBOXYLESTERASE-RXN|KEGG_REACTION:R00630|RHEA:21164|Reactome:R-HSA-9619024|UM-BBD_reactionID:r1025 GO:0016789|GO:0004302|GO:0004759|GO:0004091 molecular_function owl:Class GO:0070570 biolink:NamedThing regulation of neuron projection regeneration Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. tmpzr1t_l9r_go_relaxed.owl mah 2009-04-15T01:23:48Z biological_process owl:Class GO:0010975 biolink:NamedThing regulation of neuron projection development Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). tmpzr1t_l9r_go_relaxed.owl regulation of neurite formation|regulation of neurite biosynthesis|regulation of neurite growth|regulation of neurite development tb 2009-06-01T10:44:45Z biological_process owl:Class GO:0043487 biolink:NamedThing regulation of RNA stability Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0061616 biolink:NamedThing glycolytic process from fructose through fructose-6-phosphate The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate. tmpzr1t_l9r_go_relaxed.owl glycolysis from fructose through fructose-6-phosphate MetaCyc:PWY-5484 dph 2014-04-08T10:20:37Z biological_process owl:Class GO:0006001 biolink:NamedThing fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose. tmpzr1t_l9r_go_relaxed.owl fructose breakdown|fructose catabolism|fructose degradation biological_process owl:Class GO:1901544 biolink:NamedThing positive regulation of ent-pimara-8(14),15-diene biosynthetic process Any process that activates or increases the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process. tmpzr1t_l9r_go_relaxed.owl upregulation of ent-pimara-8(14),15-diene formation|positive regulation of ent-pimara-8(14),15-diene formation|positive regulation of ent-pimara-8(14),15-diene synthesis|upregulation of ent-pimara-8(14),15-diene biosynthetic process|up regulation of ent-pimara-8(14),15-diene anabolism|up-regulation of ent-pimara-8(14),15-diene formation|up regulation of ent-pimara-8(14),15-diene formation|activation of ent-pimara-8(14),15-diene biosynthesis|upregulation of ent-pimara-8(14),15-diene biosynthesis|upregulation of ent-pimara-8(14),15-diene anabolism|up-regulation of ent-pimara-8(14),15-diene anabolism|positive regulation of ent-pimara-8(14),15-diene biosynthesis|up regulation of ent-pimara-8(14),15-diene biosynthetic process|activation of ent-pimara-8(14),15-diene biosynthetic process|positive regulation of ent-pimara-8(14),15-diene anabolism|up-regulation of ent-pimara-8(14),15-diene biosynthetic process|activation of ent-pimara-8(14),15-diene formation|activation of ent-pimara-8(14),15-diene anabolism|activation of ent-pimara-8(14),15-diene synthesis|upregulation of ent-pimara-8(14),15-diene synthesis|up-regulation of ent-pimara-8(14),15-diene synthesis|up regulation of ent-pimara-8(14),15-diene synthesis|up-regulation of ent-pimara-8(14),15-diene biosynthesis|up regulation of ent-pimara-8(14),15-diene biosynthesis di 2012-10-26T11:38:07Z biological_process owl:Class GO:0045828 biolink:NamedThing positive regulation of isoprenoid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid. tmpzr1t_l9r_go_relaxed.owl up-regulation of isoprenoid metabolic process|stimulation of isoprenoid metabolic process|upregulation of isoprenoid metabolic process|positive regulation of isoprenoid metabolism|activation of isoprenoid metabolic process|up regulation of isoprenoid metabolic process biological_process owl:Class GO:1990532 biolink:NamedThing stress response to nickel ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus. tmpzr1t_l9r_go_relaxed.owl response to nickel ion stress|response to nickel toxicity|stress response to nickel kmv 2014-11-07T18:35:31Z biological_process owl:Class GO:0097501 biolink:NamedThing stress response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus. tmpzr1t_l9r_go_relaxed.owl response to metal ion toxicity|response to metal toxicity|response to metal ion stress|response to excess metal ion pr 2013-08-15T10:37:45Z biological_process owl:Class GO:0002927 biolink:NamedThing archaeosine-tRNA biosynthetic process The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs. tmpzr1t_l9r_go_relaxed.owl Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine. hjd 2012-01-18T03:06:27Z biological_process owl:Class GO:0009058 biolink:NamedThing biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. tmpzr1t_l9r_go_relaxed.owl multicellular organismal biosynthetic process|anabolism|single-organism biosynthetic process|biosynthesis|formation|synthesis Wikipedia:Anabolism jl 2012-10-17T15:52:18Z GO:0044274|GO:0044711 biological_process owl:Class GO:2000780 biolink:NamedThing negative regulation of double-strand break repair Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair. tmpzr1t_l9r_go_relaxed.owl bf 2011-06-23T09:28:08Z biological_process owl:Class GO:2000779 biolink:NamedThing regulation of double-strand break repair Any process that modulates the frequency, rate or extent of double-strand break repair. tmpzr1t_l9r_go_relaxed.owl bf 2011-06-23T09:28:02Z biological_process owl:Class GO:1903726 biolink:NamedThing negative regulation of phospholipid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid metabolic process. tmpzr1t_l9r_go_relaxed.owl down regulation of phospholipid metabolism|downregulation of phospholipid metabolic process|downregulation of phospholipid metabolism|down-regulation of phospholipid metabolism|inhibition of phospholipid metabolism|down-regulation of phospholipid metabolic process|negative regulation of phospholipid metabolism|inhibition of phospholipid metabolic process|down regulation of phospholipid metabolic process sl 2014-12-09T20:49:35Z biological_process owl:Class GO:0045833 biolink:NamedThing negative regulation of lipid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. tmpzr1t_l9r_go_relaxed.owl downregulation of lipid metabolic process|negative regulation of lipid metabolism|down regulation of lipid metabolic process|inhibition of lipid metabolic process|down-regulation of lipid metabolic process biological_process owl:Class GO:0046340 biolink:NamedThing diacylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. tmpzr1t_l9r_go_relaxed.owl diacylglycerol degradation|diacylglycerol breakdown|diacylglycerol catabolism|diglyceride catabolism biological_process owl:Class GO:0046339 biolink:NamedThing diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. tmpzr1t_l9r_go_relaxed.owl diacylglycerol metabolism|diglyceride metabolism biological_process owl:Class GO:0042849 biolink:NamedThing L-sorbose biosynthetic process The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol. tmpzr1t_l9r_go_relaxed.owl L-sorbose formation|L-sorbose anabolism|L-sorbose synthesis|L-sorbose biosynthesis biological_process owl:Class GO:0042847 biolink:NamedThing sorbose biosynthetic process The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. tmpzr1t_l9r_go_relaxed.owl sorbose formation|sorbose biosynthesis|sorbose anabolism|sorbose synthesis biological_process owl:Class GO:1904023 biolink:NamedThing regulation of glucose catabolic process to lactate via pyruvate Any process that modulates the frequency, rate or extent of glucose catabolic process to lactate via pyruvate. tmpzr1t_l9r_go_relaxed.owl regulation of homofermentative lactate fermentation|regulation of homolactate fermentation|regulation of homofermentative pathway|regulation of homolactic fermentation|regulation of glucose fermentation to lactate via pyruvate|regulation of homofermentation dph 2015-03-11T16:57:32Z biological_process owl:Class GO:1903578 biolink:NamedThing regulation of ATP metabolic process Any process that modulates the frequency, rate or extent of ATP metabolic process. tmpzr1t_l9r_go_relaxed.owl regulation of ATP metabolism sl 2014-10-30T19:04:24Z biological_process owl:Class GO:0090257 biolink:NamedThing regulation of muscle system process Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. tmpzr1t_l9r_go_relaxed.owl tb 2010-02-03T11:48:13Z biological_process owl:Class GO:1990861 biolink:NamedThing Ubp3-Bre5 deubiquitination complex A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p. tmpzr1t_l9r_go_relaxed.owl Ubp3-Bre5 ubiquitin protease complex rb 2015-09-24T17:56:53Z cellular_component owl:Class GO:1903811 biolink:NamedThing L-asparagine import across plasma membrane The directed movement of L-asparagine from outside of a cell, across the plasma membrane and into the cytosol. tmpzr1t_l9r_go_relaxed.owl L-asparagine import into cell|asparagine import tb 2012-09-24T14:28:58Z GO:0090469 biological_process owl:Class GO:0015807 biolink:NamedThing L-amino acid transport The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0043763 biolink:NamedThing UTP:glucose-1-phosphate uridylyltransferase regulator activity Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase. tmpzr1t_l9r_go_relaxed.owl UDP-glucose pyrophosphorylase regulator activity|UDP-glucose diphosphorylase regulator activity|glucose-1-phosphate uridylyltransferase regulator activity molecular_function owl:Class GO:1905852 biolink:NamedThing positive regulation of backward locomotion Any process that activates or increases the frequency, rate or extent of backward locomotion. tmpzr1t_l9r_go_relaxed.owl up regulation of backward locomotion|up-regulation of backward locomotion|upregulation of backward locomotion|activation of backward locomotion rz 2017-01-23T11:04:25Z biological_process owl:Class GO:1900347 biolink:NamedThing positive regulation of methane biosynthetic process from methanethiol Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methanethiol. tmpzr1t_l9r_go_relaxed.owl upregulation of methane biosynthetic process from methanethiol|up regulation of methane biosynthetic process from methanethiol|activation of methane biosynthetic process from methanethiol|up-regulation of methane biosynthetic process from methanethiol tt 2012-04-06T02:10:06Z biological_process owl:Class GO:1901579 biolink:NamedThing positive regulation of alkane biosynthetic process Any process that activates or increases the frequency, rate or extent of alkane biosynthetic process. tmpzr1t_l9r_go_relaxed.owl upregulation of alkane synthesis|up-regulation of alkane biosynthetic process|activation of alkane anabolism|up regulation of alkane biosynthesis|up regulation of alkane formation|up-regulation of alkane formation|positive regulation of alkane biosynthesis|up regulation of alkane anabolism|up-regulation of alkane biosynthesis|positive regulation of alkane synthesis|activation of alkane biosynthetic process|up-regulation of alkane synthesis|upregulation of alkane biosynthesis|upregulation of alkane formation|activation of alkane formation|up regulation of alkane synthesis|activation of alkane synthesis|up regulation of alkane biosynthetic process|activation of alkane biosynthesis|up-regulation of alkane anabolism|positive regulation of alkane formation|positive regulation of alkane anabolism|upregulation of alkane anabolism|upregulation of alkane biosynthetic process dhl 2012-11-05T21:54:19Z biological_process owl:Class GO:0032651 biolink:NamedThing regulation of interleukin-1 beta production Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. tmpzr1t_l9r_go_relaxed.owl regulation of interleukin-1 beta secretion|regulation of interleukin-1 beta biosynthetic process|regulation of IL-1 beta production GO:0050706|GO:0050722 biological_process owl:Class GO:0032652 biolink:NamedThing regulation of interleukin-1 production Any process that modulates the frequency, rate, or extent of interleukin-1 production. tmpzr1t_l9r_go_relaxed.owl regulation of interleukin-1 secretion|regulation of IL-1 production|regulation of interleukin-1 biosynthetic process GO:0050704|GO:0045360 biological_process owl:Class GO:2000731 biolink:NamedThing negative regulation of termination of RNA polymerase I transcription Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase I transcription. tmpzr1t_l9r_go_relaxed.owl negative regulation of transcription termination from RNA polymerase I promoter|negative regulation of transcription termination from Pol I promoter|negative regulation of RNA polymerase I transcription termination dph 2011-06-10T08:43:44Z biological_process owl:Class GO:2000730 biolink:NamedThing regulation of termination of RNA polymerase I transcription Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription. tmpzr1t_l9r_go_relaxed.owl regulation of transcription termination from RNA polymerase I promoter|regulation of transcription termination from Pol I promoter|regulation of RNA polymerase I transcription termination dph 2011-06-10T08:43:39Z biological_process owl:Class GO:0009952 biolink:NamedThing anterior/posterior pattern specification The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. tmpzr1t_l9r_go_relaxed.owl anterior/posterior pattern formation biological_process owl:Class GO:0003002 biolink:NamedThing regionalization The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. tmpzr1t_l9r_go_relaxed.owl pattern formation biological_process owl:Class GO:1903804 biolink:NamedThing glycine import across plasma membrane The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol. tmpzr1t_l9r_go_relaxed.owl glycine import|glycine import into cell bf 2012-05-11T01:16:45Z GO:0036233 biological_process owl:Class GO:0098656 biolink:NamedThing anion transmembrane transport The process in which an anion is transported across a membrane. tmpzr1t_l9r_go_relaxed.owl ATP hydrolysis coupled anion transmembrane transport GO:0099133 biological_process owl:Class GO:0042047 biolink:NamedThing W-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. tmpzr1t_l9r_go_relaxed.owl Moco biosynthesis|Moco biosynthetic process|W-molybdopterin cofactor formation|W-molybdopterin cofactor anabolism|W-molybdopterin cofactor synthesis|W-molybdopterin cofactor biosynthesis biological_process owl:Class GO:0008460 biolink:NamedThing dTDP-glucose 4,6-dehydratase activity Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O. tmpzr1t_l9r_go_relaxed.owl dTDP-glucose 4,6-hydro-lyase activity|thymidine diphosphoglucose oxidoreductase activity|dTDPglucose 4,6-dehydratase activity|dTDPglucose 4,6-hydro-lyase activity|dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)|TDP-glucose oxidoreductase activity MetaCyc:DTDPGLUCDEHYDRAT-RXN|KEGG_REACTION:R06513|EC:4.2.1.46|RHEA:17221 molecular_function owl:Class GO:0033672 biolink:NamedThing positive regulation of NAD+ kinase activity Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule. tmpzr1t_l9r_go_relaxed.owl NAD+ kinase activator|up-regulation of NAD+ kinase activity|upregulation of NAD+ kinase activity|stimulation of NAD+ kinase activity|up regulation of NAD+ kinase activity biological_process owl:Class GO:0021503 biolink:NamedThing neural fold bending The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0070167 biolink:NamedThing regulation of biomineral tissue development Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:2000026 biolink:NamedThing regulation of multicellular organismal development Any process that modulates the frequency, rate or extent of multicellular organismal development. tmpzr1t_l9r_go_relaxed.owl tb 2010-08-05T11:25:59Z biological_process owl:Class GO:1902107 biolink:NamedThing positive regulation of leukocyte differentiation Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. tmpzr1t_l9r_go_relaxed.owl upregulation of leukocyte differentiation|activation of immune cell differentiation|up regulation of leukocyte differentiation|positive regulation of immune cell differentiation|activation of leucocyte differentiation|positive regulation of leucocyte differentiation|upregulation of leucocyte differentiation|up-regulation of leucocyte differentiation|upregulation of immune cell differentiation|up regulation of immune cell differentiation|activation of leukocyte differentiation|up-regulation of immune cell differentiation|up regulation of leucocyte differentiation|up-regulation of leukocyte differentiation pr 2013-05-02T17:32:52Z biological_process owl:Class GO:1902105 biolink:NamedThing regulation of leukocyte differentiation Any process that modulates the frequency, rate or extent of leukocyte differentiation. tmpzr1t_l9r_go_relaxed.owl regulation of leucocyte differentiation|regulation of immune cell differentiation pr 2013-05-02T17:32:42Z biological_process owl:Class GO:0034651 biolink:NamedThing cortisol biosynthetic process The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties. tmpzr1t_l9r_go_relaxed.owl cortisol anabolism|cortisol formation|cortisol biosynthesis|cortisol synthesis biological_process owl:Class GO:1902645 biolink:NamedThing tertiary alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of tertiary alcohol. tmpzr1t_l9r_go_relaxed.owl tertiary alcohol biosynthesis|tertiary alcohol formation|tertiary alcohol synthesis|tertiary alcohol anabolism tt 2014-01-21T17:54:02Z biological_process owl:Class GO:0032413 biolink:NamedThing negative regulation of ion transmembrane transporter activity Any process that stops or reduces the activity of an ion transporter. tmpzr1t_l9r_go_relaxed.owl inhibition of ion transporter activity|down regulation of ion transporter activity|down-regulation of ion transporter activity|downregulation of ion transporter activity|negative regulation of ion transporter activity biological_process owl:Class GO:0034766 biolink:NamedThing negative regulation of ion transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl down regulation of transmembrane ion transport|downregulation of transmembrane ion transport|negative regulation of ion membrane transport|down-regulation of transmembrane ion transport|inhibition of transmembrane ion transport|negative regulation of transmembrane ion transport biological_process owl:Class GO:0097697 biolink:NamedThing tRNA 5-carboxymethoxyuridine methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosylmethionine to a 5-carboxymethoxy-modified uridine residue in a tRNA molecule. tmpzr1t_l9r_go_relaxed.owl pr 2016-01-07T10:36:46Z molecular_function owl:Class GO:0016300 biolink:NamedThing tRNA (uracil) methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. tmpzr1t_l9r_go_relaxed.owl tRNA (uridine) methyltransferase activity Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). GO:0016431 molecular_function owl:Class GO:2000302 biolink:NamedThing positive regulation of synaptic vesicle exocytosis Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis. tmpzr1t_l9r_go_relaxed.owl dph 2011-01-03T08:21:14Z biological_process owl:Class GO:0001956 biolink:NamedThing positive regulation of neurotransmitter secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. tmpzr1t_l9r_go_relaxed.owl stimulation of neurotransmitter secretion|activation of neurotransmitter secretion|up regulation of neurotransmitter secretion|up-regulation of neurotransmitter secretion|upregulation of neurotransmitter secretion biological_process owl:Class GO:0071587 biolink:NamedThing CAAX-box protein modification The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins. tmpzr1t_l9r_go_relaxed.owl mah 2010-01-28T04:48:56Z biological_process owl:Class GO:0043687 biolink:NamedThing post-translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. tmpzr1t_l9r_go_relaxed.owl posttranslational modification|post-translational modification|PTM|post-translational amino acid modification|posttranslational amino acid modification|posttranslational protein modification Wikipedia:Posttranslational_modification This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term. biological_process owl:Class GO:0045572 biolink:NamedThing positive regulation of imaginal disc growth Any process that activates or increases the frequency, rate or extent of imaginal disc growth. tmpzr1t_l9r_go_relaxed.owl up regulation of imaginal disc growth|upregulation of imaginal disc growth|stimulation of imaginal disc growth|activation of imaginal disc growth|up-regulation of imaginal disc growth biological_process owl:Class GO:0045570 biolink:NamedThing regulation of imaginal disc growth Any process that modulates the frequency, rate or extent of the growth of the imaginal disc. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0015189 biolink:NamedThing L-lysine transmembrane transporter activity Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. tmpzr1t_l9r_go_relaxed.owl histidine/arginine/lysine/ornithine porter activity|lysine permease activity|L-lysine permease GO:0005293 molecular_function owl:Class GO:0008324 biolink:NamedThing cation transmembrane transporter activity Enables the transfer of cation from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl transmembrane cation transporter activity molecular_function owl:Class GO:0090063 biolink:NamedThing positive regulation of microtubule nucleation Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. tmpzr1t_l9r_go_relaxed.owl tb 2009-08-12T11:33:09Z biological_process owl:Class GO:0010968 biolink:NamedThing regulation of microtubule nucleation Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. tmpzr1t_l9r_go_relaxed.owl tb 2009-05-20T11:51:21Z biological_process owl:Class GO:1905850 biolink:NamedThing positive regulation of forward locomotion Any process that activates or increases the frequency, rate or extent of forward locomotion. tmpzr1t_l9r_go_relaxed.owl activation of forward locomotion|upregulation of forward locomotion|up-regulation of forward locomotion|up regulation of forward locomotion rz 2017-01-23T11:04:05Z biological_process owl:Class GO:0040017 biolink:NamedThing positive regulation of locomotion Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. tmpzr1t_l9r_go_relaxed.owl up-regulation of locomotion|activation of locomotion|upregulation of locomotion|up regulation of locomotion|stimulation of locomotion biological_process owl:Class GO:0090344 biolink:NamedThing negative regulation of cell aging Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. tmpzr1t_l9r_go_relaxed.owl tb 2010-06-02T10:12:37Z biological_process owl:Class GO:0090342 biolink:NamedThing regulation of cell aging Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. tmpzr1t_l9r_go_relaxed.owl tb 2010-06-02T10:12:37Z biological_process owl:Class GO:0030995 biolink:NamedThing cell septum edging catabolic process The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation. tmpzr1t_l9r_go_relaxed.owl cell septum edging hydrolysis|septum edging hydrolysis|hydrolysis of cell septum edging|hydrolysis of edging of cell septum biological_process owl:Class GO:0071999 biolink:NamedThing extracellular polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures. tmpzr1t_l9r_go_relaxed.owl extracellular polysaccharide breakdown|extracellular polysaccharide catabolism|extracellular polysaccharide degradation mah 2010-10-25T05:11:25Z biological_process owl:Class GO:1901631 biolink:NamedThing positive regulation of presynaptic membrane organization Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization. tmpzr1t_l9r_go_relaxed.owl positive regulation of presynaptic membrane organisation|up regulation of presynaptic membrane organisation|positive regulation of pre-synaptic membrane organization|upregulation of presynaptic membrane organisation|up-regulation of presynaptic membrane organization|upregulation of presynaptic membrane organization|up regulation of presynaptic membrane organization|activation of presynaptic membrane organisation|up-regulation of presynaptic membrane organisation|activation of presynaptic membrane organization ans 2012-11-15T11:40:40Z biological_process owl:Class GO:2000766 biolink:NamedThing negative regulation of cytoplasmic translation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation. tmpzr1t_l9r_go_relaxed.owl vw 2011-06-20T10:39:23Z biological_process owl:Class GO:0016936 biolink:NamedThing galactoside binding Binding to a glycoside in which the sugar group is galactose. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0043847 biolink:NamedThing DNA polymerase III, clamp loader chi/psi subcomplex A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB). tmpzr1t_l9r_go_relaxed.owl DNA polymerase III, DnaX complex, chi/psi subcomplex cellular_component owl:Class GO:0050190 biolink:NamedThing phosphoglucokinase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H(+). tmpzr1t_l9r_go_relaxed.owl ATP:D-glucose-1-phosphate 6-phosphotransferase activity|phosphoglucokinase (phosphorylating)|glucose-phosphate kinase activity|ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity RHEA:13377|MetaCyc:PHOSPHOGLUCOKINASE-RXN|EC:2.7.1.10|KEGG_REACTION:R00949 molecular_function owl:Class GO:0090194 biolink:NamedThing negative regulation of glomerulus development Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. tmpzr1t_l9r_go_relaxed.owl tb 2009-12-18T11:17:13Z biological_process owl:Class GO:0090192 biolink:NamedThing regulation of glomerulus development Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. tmpzr1t_l9r_go_relaxed.owl tb 2009-12-18T11:17:13Z biological_process owl:Class GO:0008108 biolink:NamedThing UDP-glucose:hexose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. tmpzr1t_l9r_go_relaxed.owl UDP-glucose-hexose-1-phosphate uridylyltransferase activity|Gal-1-P uridylyltransferase activity|UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity|uridyltransferase activity|UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity|uridylyl removing enzyme activity|UDPglucose-hexose-1-phosphate uridylyltransferase activity|galactose-1-phosphate uridylyltransferase activity|hexose 1-phosphate uridyltransferase activity|hexose-1-phosphate uridylyltransferase activity|uridyl transferase activity Reactome:R-HSA-70361|MetaCyc:GALACTURIDYLYLTRANS-RXN|EC:2.7.7.12|KEGG_REACTION:R00955|RHEA:13989|Reactome:R-HSA-5610038 molecular_function owl:Class GO:0070569 biolink:NamedThing uridylyltransferase activity Catalysis of the transfer of an uridylyl group to an acceptor. tmpzr1t_l9r_go_relaxed.owl uridyltransferase activity|uridyl transferase activity mah 2009-04-15T11:06:07Z molecular_function owl:Class GO:0034116 biolink:NamedThing positive regulation of heterotypic cell-cell adhesion Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0034114 biolink:NamedThing regulation of heterotypic cell-cell adhesion Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0009441 biolink:NamedThing glycolate metabolic process The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid). tmpzr1t_l9r_go_relaxed.owl glycolate metabolism MetaCyc:GLYCOLATEMET-PWY biological_process owl:Class GO:0034308 biolink:NamedThing primary alcohol metabolic process The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. tmpzr1t_l9r_go_relaxed.owl primary alcohol metabolism|monohydric alcohol metabolic process biological_process owl:Class GO:0031431 biolink:NamedThing Dbf4-dependent protein kinase complex A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins. tmpzr1t_l9r_go_relaxed.owl Cdc7-Dbf4 complex|Hsk1-Dfp1 kinase complex|DDK cellular_component owl:Class GO:0140535 biolink:NamedThing intracellular protein-containing complex A protein-containing complex located intracellularly. tmpzr1t_l9r_go_relaxed.owl https://github.com/geneontology/go-ontology/issues/19952 pg 2020-10-28T14:40:16Z cellular_component owl:Class GO:0060876 biolink:NamedThing semicircular canal formation The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes. tmpzr1t_l9r_go_relaxed.owl dph 2009-08-13T09:45:07Z biological_process owl:Class GO:0035148 biolink:NamedThing tube formation Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. tmpzr1t_l9r_go_relaxed.owl lumen formation in an anatomical structure|tube lumen formation biological_process owl:Class GO:0071222 biolink:NamedThing cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. tmpzr1t_l9r_go_relaxed.owl cellular response to endotoxin|cellular response to LPS mah 2009-12-03T01:29:29Z biological_process owl:Class GO:0050774 biolink:NamedThing negative regulation of dendrite morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. tmpzr1t_l9r_go_relaxed.owl inhibition of dendrite morphogenesis|downregulation of dendrite morphogenesis|down regulation of dendrite morphogenesis|down-regulation of dendrite morphogenesis biological_process owl:Class GO:0048814 biolink:NamedThing regulation of dendrite morphogenesis Any process that modulates the frequency, rate or extent of dendrite morphogenesis. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0032827 biolink:NamedThing negative regulation of natural killer cell differentiation involved in immune response Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response. tmpzr1t_l9r_go_relaxed.owl negative regulation of natural killer cell differentiation during immune response|negative regulation of NK cell differentiation during immune response|downregulation of natural killer cell differentiation during immune response|down-regulation of natural killer cell differentiation during immune response|inhibition of natural killer cell differentiation during immune response|down regulation of natural killer cell differentiation during immune response|negative regulation of natural killer cell development involved in immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:0032826 biolink:NamedThing regulation of natural killer cell differentiation involved in immune response Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response. tmpzr1t_l9r_go_relaxed.owl regulation of natural killer cell differentiation during immune response|regulation of natural killer cell development involved in immune response|regulation of NK cell differentiation during immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class GO:0050203 biolink:NamedThing oxalate-CoA ligase activity Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA. tmpzr1t_l9r_go_relaxed.owl oxalate:CoA ligase (AMP-forming)|oxalyl coenzyme A synthetase activity|oxalyl-CoA synthetase activity MetaCyc:OXALATE--COA-LIGASE-RXN|EC:6.2.1.8|RHEA:18293|KEGG_REACTION:R01558 molecular_function owl:Class GO:0016878 biolink:NamedThing acid-thiol ligase activity Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. tmpzr1t_l9r_go_relaxed.owl EC:6.2.1.- molecular_function owl:Class GO:0051573 biolink:NamedThing negative regulation of histone H3-K9 methylation Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. tmpzr1t_l9r_go_relaxed.owl down-regulation of histone H3-K9 methylation|downregulation of histone H3-K9 methylation|down regulation of histone H3-K9 methylation|inhibition of histone H3-K9 methylation biological_process owl:Class GO:1903296 biolink:NamedThing positive regulation of glutamate secretion, neurotransmission Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter. tmpzr1t_l9r_go_relaxed.owl activation of glutamate secretion, neurotransmission|up-regulation of glutamate secretion, neurotransmission|up regulation of glutamate secretion, neurotransmission|upregulation of glutamate secretion, neurotransmission An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype pad 2014-08-13T13:54:31Z biological_process owl:Class GO:1901435 biolink:NamedThing negative regulation of toluene catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of toluene catabolic process. tmpzr1t_l9r_go_relaxed.owl inhibition of toluene catabolism|negative regulation of toluene breakdown|inhibition of toluene breakdown|negative regulation of toluene degradation|downregulation of toluene breakdown|negative regulation of toluene catabolism|down-regulation of toluene catabolism|down regulation of toluene catabolism|inhibition of toluene degradation|downregulation of toluene degradation|down-regulation of toluene catabolic process|down-regulation of toluene breakdown|down-regulation of toluene degradation|downregulation of toluene catabolism|inhibition of toluene catabolic process|down regulation of toluene degradation|downregulation of toluene catabolic process|down regulation of toluene catabolic process|down regulation of toluene breakdown tt 2012-10-01T21:13:41Z biological_process owl:Class GO:0003186 biolink:NamedThing tricuspid valve morphogenesis The process in which the structure of the tricuspid valve is generated and organized. tmpzr1t_l9r_go_relaxed.owl dph 2009-10-08T12:05:45Z biological_process owl:Class GO:0003181 biolink:NamedThing atrioventricular valve morphogenesis The process in which the structure of the atrioventricular valve is generated and organized. tmpzr1t_l9r_go_relaxed.owl AV valve morphogenesis dph 2009-10-08T11:31:59Z biological_process owl:Class GO:0060893 biolink:NamedThing limb granular cell fate specification The process in which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. tmpzr1t_l9r_go_relaxed.owl dph 2009-08-13T01:44:14Z biological_process owl:Class GO:0060573 biolink:NamedThing cell fate specification involved in pattern specification The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. tmpzr1t_l9r_go_relaxed.owl dph 2009-05-05T02:19:14Z biological_process owl:Class GO:0004947 biolink:NamedThing bradykinin receptor activity Combining with bradykinin to initiate a change in cell activity. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:2001145 biolink:NamedThing negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. tmpzr1t_l9r_go_relaxed.owl yaf 2011-10-19T10:41:28Z biological_process owl:Class GO:2001144 biolink:NamedThing regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Any process that modulates the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. tmpzr1t_l9r_go_relaxed.owl yaf 2011-10-19T10:41:25Z biological_process owl:Class GO:2001256 biolink:NamedThing regulation of store-operated calcium entry Any process that modulates the frequency, rate or extent of store-operated calcium entry. tmpzr1t_l9r_go_relaxed.owl regulation of SOCE|regulation of store-operated calcium import|regulation of capacitative calcium entry|regulation of calcium ion import vk 2011-12-07T07:08:38Z biological_process owl:Class GO:0051924 biolink:NamedThing regulation of calcium ion transport Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. tmpzr1t_l9r_go_relaxed.owl regulation of calcium transport biological_process owl:Class GO:0015438 biolink:NamedThing ABC-type teichoic acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out). tmpzr1t_l9r_go_relaxed.owl ATP-dependent teichoic acid transmembrane transporter activity|teichoic acid transmembrane transporter activity|ABC-type teichoic-acid transporter|ATPase-coupled teichoic acid transmembrane transporter activity|teichoic-acid-transporting ATPase activity|teichoic-acid ABC transporter MetaCyc:3.6.3.40-RXN|EC:7.5.2.4 GO:0015162 molecular_function owl:Class GO:0022884 biolink:NamedThing macromolecule transmembrane transporter activity Enables the transfer of a macromolecule from one side of a membrane to the other. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:1900490 biolink:NamedThing positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity Any process that activates or increases the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity. tmpzr1t_l9r_go_relaxed.owl upregulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|up regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|up-regulation of HMG-CoA reductase activity|up regulation of HMG-CoA reductase activity|upregulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity|up regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity|positive regulation of HMG-CoA reductase activity|up-regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity|activation of hydroxymethylglutaryl-CoA reductase (NADPH) activity|up-regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|upregulation of HMG-CoA reductase activity|positive regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|activation of HMG-CoA reductase activity|activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity al 2012-05-02T03:01:43Z biological_process owl:Class GO:0051353 biolink:NamedThing positive regulation of oxidoreductase activity Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. tmpzr1t_l9r_go_relaxed.owl up regulation of oxidoreductase activity|activation of oxidoreductase activity|stimulation of oxidoreductase activity|oxidoreductase activator|up-regulation of oxidoreductase activity|upregulation of oxidoreductase activity|ribonucleotide reductase activating enzyme activity GO:0009391 biological_process owl:Class GO:1902953 biolink:NamedThing positive regulation of ER to Golgi vesicle-mediated transport Any process that activates or increases the frequency, rate or extent of ER to Golgi vesicle-mediated transport. tmpzr1t_l9r_go_relaxed.owl up regulation of ER to Golgi vesicle-mediated transport|upregulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|positive regulation of rough endoplasmic reticulum to cis-Golgi transport|upregulation of rough endoplasmic reticulum to cis-Golgi transport|positive regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|up regulation of endoplasmic reticulum to Golgi transport|up regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|up-regulation of rough endoplasmic reticulum to cis-Golgi transport|activation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|activation of rough ER to cis-Golgi vesicle-mediated transport|up-regulation of ER to Golgi vesicle-mediated transport|up-regulation of rough ER to cis-Golgi transport|up regulation of rough ER to cis-Golgi vesicle-mediated transport|positive regulation of rough ER to cis-Golgi transport|activation of rough endoplasmic reticulum to cis-Golgi transport|upregulation of ER to Golgi vesicle-mediated transport|up regulation of rough endoplasmic reticulum to cis-Golgi transport|up regulation of endoplasmic reticulum to Golgi vesicle-mediated transport|upregulation of endoplasmic reticulum to Golgi transport|positive regulation of rough ER to cis-Golgi vesicle-mediated transport|positive regulation of endoplasmic reticulum to Golgi transport|upregulation of rough ER to cis-Golgi vesicle-mediated transport|upregulation of rough ER to cis-Golgi transport|positive regulation of ER to Golgi transport|up regulation of ER to Golgi transport|upregulation of ER to Golgi transport|upregulation of endoplasmic reticulum to Golgi vesicle-mediated transport|up-regulation of endoplasmic reticulum to Golgi transport|up-regulation of ER to Golgi transport|up-regulation of endoplasmic reticulum to Golgi vesicle-mediated transport|activation of rough ER to cis-Golgi transport|activation of endoplasmic reticulum to Golgi transport|up-regulation of rough ER to cis-Golgi vesicle-mediated transport|activation of ER to Golgi vesicle-mediated transport|activation of ER to Golgi transport|up-regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|up regulation of rough ER to cis-Golgi transport|positive regulation of endoplasmic reticulum to Golgi vesicle-mediated transport|activation of endoplasmic reticulum to Golgi vesicle-mediated transport sjp 2014-05-02T08:59:18Z biological_process owl:Class GO:0032388 biolink:NamedThing positive regulation of intracellular transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. tmpzr1t_l9r_go_relaxed.owl up regulation of intracellular transport|up-regulation of intracellular transport|upregulation of intracellular transport|activation of intracellular transport|stimulation of intracellular transport biological_process owl:Class GO:0031452 biolink:NamedThing negative regulation of heterochromatin assembly Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation. tmpzr1t_l9r_go_relaxed.owl negative regulation of heterochromatin formation|inhibition of heterochromatin formation|downregulation of heterochromatin formation|down regulation of heterochromatin formation|down-regulation of heterochromatin formation biological_process owl:Class GO:0120262 biolink:NamedThing negative regulation of heterochromatin organization Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization. tmpzr1t_l9r_go_relaxed.owl downregulation of heterochromatin organization|inhibition of heterochromatin organization|down regulation of heterochromatin organization|down-regulation of heterochromatin organization https://github.com/geneontology/go-ontology/issues/20020 krc 2020-09-29T20:12:30Z biological_process owl:Class GO:0031409 biolink:NamedThing pigment binding Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0005488 biolink:NamedThing binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. tmpzr1t_l9r_go_relaxed.owl ligand Wikipedia:Binding_(molecular) Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. molecular_function owl:Class GO:0031396 biolink:NamedThing regulation of protein ubiquitination Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0045823 biolink:NamedThing positive regulation of heart contraction Any process that activates or increases the frequency, rate or extent of heart contraction. tmpzr1t_l9r_go_relaxed.owl up-regulation of heart contraction|activation of heart contraction|positive regulation of cardiac contraction|stimulation of heart contraction|up regulation of heart contraction|upregulation of heart contraction biological_process owl:Class GO:1903524 biolink:NamedThing positive regulation of blood circulation Any process that activates or increases the frequency, rate or extent of blood circulation. tmpzr1t_l9r_go_relaxed.owl positive regulation of hemolymph circulation|upregulation of hemolymph circulation|activation of blood circulation|up-regulation of hemolymph circulation|upregulation of blood circulation|up regulation of hemolymph circulation|activation of hemolymph circulation|up regulation of blood circulation|up-regulation of blood circulation mr 2014-10-06T18:39:13Z biological_process owl:Class GO:0033631 biolink:NamedThing cell-cell adhesion mediated by integrin The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. tmpzr1t_l9r_go_relaxed.owl cell-cell adhesion mediated by integrin complex biological_process owl:Class GO:0033627 biolink:NamedThing cell adhesion mediated by integrin The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. tmpzr1t_l9r_go_relaxed.owl cell adhesion mediated by integrin complex biological_process owl:Class GO:0090441 biolink:NamedThing trehalose biosynthesis in response to heat stress The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. tmpzr1t_l9r_go_relaxed.owl trehalose biosynthetic process in response to heat stress tb 2012-08-23T13:53:07Z biological_process owl:Class GO:0070414 biolink:NamedThing trehalose metabolism in response to heat stress The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. tmpzr1t_l9r_go_relaxed.owl trehalose metabolic process involved in response to heat stress biological_process owl:Class GO:0080173 biolink:NamedThing male-female gamete recognition during double fertilization forming a zygote and endosperm The initial contact step made between the male gamete and the female gamete during double fertilization forming a zygote and endosperm. An example can be found in Arabidopsis thaliana. tmpzr1t_l9r_go_relaxed.owl male-female gamete recognition|gamete recognition dhl 2011-04-26T04:58:58Z biological_process owl:Class GO:0009988 biolink:NamedThing cell-cell recognition Cell recognition between cells. May involve the formation of specialized cell junctions. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0019617 biolink:NamedThing protocatechuate catabolic process, meta-cleavage The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate. tmpzr1t_l9r_go_relaxed.owl protocatechuate degradation, meta-cleavage|protocatechuate catabolic process to oxaloacetate and pyruvate|protocatechuate breakdown, meta-cleavage|3,4-dihydroxybenzoate catabolic process, meta-cleavage MetaCyc:P184-PWY biological_process owl:Class GO:0006107 biolink:NamedThing oxaloacetate metabolic process The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. tmpzr1t_l9r_go_relaxed.owl oxaloacetate metabolism biological_process owl:Class GO:0070457 biolink:NamedThing D-galactose-1-phosphate phosphatase activity Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0070456 biolink:NamedThing galactose-1-phosphate phosphatase activity Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0004945 biolink:NamedThing angiotensin type II receptor activity An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0001595 biolink:NamedThing angiotensin receptor activity Combining with angiotensin to initiate a change in cell activity. tmpzr1t_l9r_go_relaxed.owl molecular_function owl:Class GO:0050795 biolink:NamedThing regulation of behavior Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. tmpzr1t_l9r_go_relaxed.owl regulation of behaviour biological_process owl:Class GO:0050967 biolink:NamedThing detection of electrical stimulus involved in sensory perception of pain The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. tmpzr1t_l9r_go_relaxed.owl perception of pain, detection of electrical stimulus|perception of pain, sensory transduction of electrical stimulus|perception of pain, sensory detection of electrical stimulus|detection of electrical stimulus during sensory perception of pain|sensory detection of electrical stimulus during perception of pain|sensory transduction of electrical stimulus during perception of pain biological_process owl:Class GO:0050981 biolink:NamedThing detection of electrical stimulus The series of events by which an electrical stimulus is received and converted into a molecular signal. tmpzr1t_l9r_go_relaxed.owl biological_process owl:Class GO:0060770 biolink:NamedThing negative regulation of epithelial cell proliferation involved in prostate gland development Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. tmpzr1t_l9r_go_relaxed.owl dph 2009-07-08T07:40:27Z biological_process owl:Class GO:0050680 biolink:NamedThing negative regulation of epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. tmpzr1t_l9r_go_relaxed.owl downregulation of epithelial cell proliferation|down regulation of epithelial cell proliferation|down-regulation of epithelial cell proliferation|inhibition of epithelial cell proliferation biological_process owl:Class GO:0103023 biolink:NamedThing ITPase activity Catalysis of the reaction: ITP + H2O <=> H+ + IDP + hydrogenphosphate. tmpzr1t_l9r_go_relaxed.owl RHEA:28330|EC:3.6.1.73|MetaCyc:RXN0-5073 molecular_function owl:Class GO:0016818 biolink:NamedThing hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. t